back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Please note that the entered identifier (PR:000025460) is not the main identifier for this entry (PR:000018574).

Protein Ontology report - CD14 molecule, signal peptide removed form
PR:000018574 - http://purl.obolibrary.org/obo/PR_000018574
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000018574   
  PRO nameCD14 molecule, signal peptide removed form 
  Synonyms
PRO-Short-label: EXACT:CD14/SigPep-
  Definition"A CD14 molecule that has had the signal peptide removed." [PRO:DNx] 
  PRO Categorymodification 
  ParentPR:000001889 CD14 molecule
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification7                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000018574 CD14 molecule, signal peptide removed form, CD14/SigPep-

modification


PR:000002146 CD14 molecule cleaved 1 soluble form, CD14/Clv:1/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human), hCD14/Clv:1/soluble
Yes
organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse), mCD14/Clv:1/soluble
Yes
modification


PR:000002148 CD14 molecule cleaved and GPI-anchored form, CD14/ClvPrd/anchored

modification


PR:000036848 CD14 molecule cleaved 2, CD14/Clv:2
Yes
modification


PR:000002147 CD14 molecule cleaved 2 soluble form, CD14/Clv:2/soluble

Yes
organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble
Yes
Yes
modification


PR:000002149 CD14 molecule cleaved 2 GPI-anchored form, CD14/Clv:2/anchored

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human), hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse), mCD14/Clv:2/anchored

Yes
organism-modification


PR:000036946 CD14 molecule cleaved 2 (mouse), mCD14/Clv:2

organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse), mCD14/Clv:2/anchored

organism-modification


PR:000037480 CD14 molecule cleaved 2 (human), hCD14/Clv:2

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human), hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble
Yes
Yes
modification


PR:000036849 CD14 molecule cleaved and soluble form, CD14/ClvPrd/soluble

Yes
modification


PR:000002146 CD14 molecule cleaved 1 soluble form, CD14/Clv:1/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human), hCD14/Clv:1/soluble
Yes
organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse), mCD14/Clv:1/soluble
Yes
modification


PR:000002147 CD14 molecule cleaved 2 soluble form, CD14/Clv:2/soluble

organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble
Yes
Yes
organism-modification


PR:000036850 CD14 molecule cleaved and soluble form (mouse), mCD14/ClvPrd/soluble

Yes
organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse), mCD14/Clv:1/soluble

organism-modification


PR:000036945 CD14 molecule cleaved and soluble form (human), hCD14/ClvPrd/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human), hCD14/Clv:1/soluble

organism-modification


PR:000050392 presepsin (human), hPSEP

Back to top
CD14/SigPep- forms found in complexes   

CD14/SigPep- Component
 Complexes
PR:000002147 CD14/Clv:2/soluble PR:000025494 LPS:secreted CD14 alpha
PR:000025496 lipopolysaccharide receptor complex 2
PR:000025498 lipopolysaccharide receptor complex 4
PR:000002149 CD14/Clv:2/anchored PR:000025493 LPS:GPI-anchored CD14 complex
PR:000025495 lipopolysaccharide receptor complex 1
PR:000025497 lipopolysaccharide receptor complex 3
PR:000035702 hCD14/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000036849 CD14/ClvPrd/soluble PR:000029989 LPS:secreted CD14 complex
PR:000036850 mCD14/ClvPrd/soluble PR:000037467 LPS:secreted CD14 complex (mouse)
PR:000037470 mCD14/Clv:2/anchored PR:000037468 LPS:GPI-anchored CD14 complex (mouse)
PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000037480 hCD14/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035702 hCD14/Clv:2/anchored
UniProtKB:P08571, 20-345, Asn-345, MOD:00167 | GPI-anchored form of CD14 (human) | GPI-N345-CD14 (human) | PRO_0000020885, Asn-345, MOD:00167
"A CD14 molecule cleaved 2 GPI-anchored form in human. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_inGO:0005886 plasma membrane Reactome:REACT_7740
GO:0005886 plasma membrane Reactome:REACT_7740
PR:000035703 hCD14/Clv:2/soluble
Secreted form of CD14 (human)
"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
enablesGO:0001530 lipopolysaccharide binding PMID:9464818
located_inCL:0000129 microglial cell PMID:24659539
GO:0005576 extracellular region PMID:2779588; PMID:9665271
PR:000036615 hCD14/Clv:1/soluble
UniProtKB:P08571, 20-367 | PRO_0000020884
"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]		 located_inGO:0005576 extracellular region PMID:7519994
PR:000036848 CD14/Clv:2

"A CD14 molecule, signal peptide removed form that lacks the propeptide. Example: UniProtKB:P08571, 20-345." [PRO:DAN]		 acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI:3836081; PMID:18854309
GO:0016020 membrane MGI:3836081; PMID:18854309
PR:000037469 mCD14/Clv:1/soluble
UniProtKB:P10810, 16-358 | Secreted CD14 (mouse)
"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]		 located_inCL:0000129 microglial cell PMID:24659539