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Protein Ontology report - E3 ubiquitin-protein ligase SIAH1 isoform 1
PR:000025622 - http://purl.obolibrary.org/obo/PR_000025622
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000025622   
  PRO nameE3 ubiquitin-protein ligase SIAH1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:SIAH1/iso:1
  Definition"An E3 ubiquitin-protein ligase SIAH1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUQ4-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000014860 E3 ubiquitin-protein ligase SIAH1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 3                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000025622 E3 ubiquitin-protein ligase SIAH1 isoform 1, SIAH1/iso:1

organism-sequence


PR:P61092-1 E3 ubiquitin-protein ligase SIAH1A isoform 1 (mouse), mSIAH1/iso:1

organism-sequence


PR:Q8IUQ4-1 E3 ubiquitin-protein ligase SIAH1 isoform 1 (human), hSIAH1/iso:1

organism-modification


PR:000025641 E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human), hSIAH1/iso:1/Phos:1
Yes
organism-modification


PR:000045369 E3 ubiquitin-protein ligase SIAH1 isoform 1 unphosphorylated 1 (human), hSIAH1/iso:1/UnPhos:1
Yes
organism-sequence


PR:Q920M9-1 E3 ubiquitin-protein ligase SIAH1 isoform 1 (rat), rSIAH1/iso:1
Yes
modification


PR:000025627 E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1, SIAH1/iso:1/Phos:1

organism-modification


PR:000025641 E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human), hSIAH1/iso:1/Phos:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025641 hSIAH1/iso:1/Phos:1
UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 in human. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048." [PMID:16230351, PMID:9482736, PRO:DAN, PRO:JAN]		 acts_upstream_of_or_withinGO:0043525 positive regulation of neuron apoptotic process PMID:16230351
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351
enablesincreased GO:0005515 protein binding with PR:Q69ZI1-1 PMID:16230351
PR:000045369 hSIAH1/iso:1/UnPhos:1
UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 (human) that lacks phosphorylation at Tyr-100 and Tyr-126. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291." [PRO:JAN]		 acts_upstream_of_or_withinGO:0043525 positive regulation of neuron apoptotic process PMID:16230351
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351
enablesGO:0005515 protein binding with PR:Q69ZI1 Kiaa1494 PMID:16230351
PR:Q920M9-1 rSIAH1/iso:1

"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]		 enablesGO:0005515 protein binding with PR:Q71F54 plenty of SH3s (rat) PMID:16230351