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Protein Ontology report - siroheme synthase
PR:000025879 -
http://purl.obolibrary.org/obo/PR_000025879
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000025879
PRO name
siroheme synthase
Definition
"A protein that is a multifunctional enzyme of the siroheme and cobalamin (vitamin B12) biosynthesis pathways, represents a fusion between uroporphyrin-III C-methyltransferase (SUMT) and precorrin-2 oxidase/chelatase. It contains a Sirohaem synthase dimerisation region (
Pfam:PF10414
) followed by the Tetrapyrrole (Corrin/Porphyrin) Methylases (
Pfam:PF00590
) domain." [
PIRSF:PIRSF036426
]
PRO Category
family
Parent
PR:000000001
protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Family
1
Organism-Family
0
Gene
1
Organism-Gene
3
Sequence
0
Organism-Sequence
0
Modification
2
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF036426
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
family
PR:000025879
siroheme synthase, chick-SERPINB14/iso:1/InitMet-/AcNGlycoPhos:1
gene
PR:000022378
siroheme synthase cysG, cysG
organism-gene
PR:O74468
probable uroporphyrinogen-III C-methyltransferase (Schizosaccharomyces pombe 972h-), Spom972h-cysG
organism-gene
PR:P0AEA8
siroheme synthase (Escherichia coli K-12), Ec-cysG
organism-gene
PR:P25924
siroheme synthase (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2), cysG (SALTY)
modification
PR:000025881
siroheme synthase cysG phosphorylated 1, cysG/Phos:1
organism-modification
PR:000025882
siroheme synthase cysG phosphorylated 1 (Salmonella typhimurium), cysG/Phos:1 (SALTM)
Yes
modification
PR:000025883
siroheme synthase cysG unmodified form, cysG/UnMod
organism-modification
PR:000025884
siroheme synthase cysG unmodified form (Salmonella typhimurium), cysG/UnMod (SALTM)
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025882
cysG/Phos:1 (SALTM)
UniProtKB:P25924, Ser-128, MOD:00046
"A siroheme synthase cysG phosphorylated 1 in Salmonella typhimurium. UniProtKB:P25924, Ser-128, MOD:00046." [OCA:JP, PMID:14595395]
enables
decreased
GO:0043115
precorrin-2 dehydrogenase activity
relative to
PR:000025884
cysG/UnMod (SALTM)
PDB:1PJQ
;
PMID:14595395
PR:000025884
cysG/UnMod (SALTM)
"A siroheme synthase cysG unmodified form in Salmonella typhimurium." [PRO:CNA, PRO:DAN]
enables
GO:0043115
precorrin-2 dehydrogenase activity
PDB:1PJQ
;
PMID:14595395