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Protein Ontology report - neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1

PR:000026192 - http://purl.obolibrary.org/obo/PR_000026192

Protein Forms

Ontology Information

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PRO ID

PR:000026192

PRO name

neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1

Synonyms

PRO-Short-label:

EXACT:

L1CAM/iso:1/SigPep-/Phos:1

Definition

"A neural cell adhesion molecule L1 isoform 1 that has been phosphorylated on the tyrosine residue of the tyrosine based sorting motif. The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. Example: UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]

PRO Category

modification

Parent

PR:000026190 neural cell adhesion molecule L1 isoform 1
PR:000037070 phosphoprotein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	1	Organism-Modification	1

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