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RACE-PRO
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Protein Ontology report - TAK1 kinase complex
PR:000027077 -
http://purl.obolibrary.org/obo/PR_000027077
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000027077
PRO name
TAK1 kinase complex
Synonyms
Other
:
RELATED:
TAK1-TAB1-TAB2-TAB3
Definition
"A protein-containing complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunit)." [
PMID:16410796
,
PMID:17496917
,
PMID:18021073
, PRO:CNA]
Comment
Requested GO term.
PRO Category
complex
Parent
G0032991
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Complex
2
Organism-Complex
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
complex
PR:000027077
TAK1 kinase complex, hGATA1/iso:1/PhosSumo:1
Yes
complex
PR:000027078
TRIKA2 complex, hGATA1/iso:1/PhosSumo:1
organism-complex
PR:000027105
TRIKA2 complex (mouse), fam:hTAB2-hTAB3
organism-complex
PR:000027102
TAK1 kinase complex (mouse), fam:mTAB2-mTAB3
organism-complex
PR:000035730
TAK1 kinase complex (human), Ubiq
Yes
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hGATA1/iso:1/PhosSumo:1
forms found in complexes
hGATA1/iso:1/PhosSumo:1
Component
Complexes
PR:000027077
hGATA1/iso:1/PhosSumo:1
PR:000027079^P000027080^P000027081
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000035730
Ubiq
TAB1:TAB2,TAB3:TAK1 (human)
acts_upstream_of_or_within
GO:0002755
MyD88-dependent toll-like receptor signaling pathway
Reactome:REACT_25222
GO:0002756
MyD88-independent toll-like receptor signaling pathway
Reactome:REACT_6809
GO:0038095
Fc-epsilon receptor signaling pathway
Reactome:REACT_163936