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Protein Ontology report - transcription adapter with TAZ, KIX and bromo-domains (human)
PR:000027108 -
http://purl.obolibrary.org/obo/PR_000027108
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000027108
PRO name
transcription adapter with TAZ, KIX and bromo-domains (human)
Synonyms
PRO-Short-label
:
EXACT:
h(CBP-p300)
Other
:
EXACT:
human CBP/p300
Definition
"A transcription adapter with TAZ, KIX and bromo-domains that is encoded in the genome of human." [PRO:CNA]
Comment
Note: Translation product of the human CREBBP or EP300 genes.
PRO Category
organism-family
Parent
PR:000000031
transcription adapter with TAZ, KIX and bromo-domains
PR:000029067
Homo sapiens protein
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Family
0
Organism-Family
1
Gene
0
Organism-Gene
2
Sequence
0
Organism-Sequence
3
Modification
0
Organism-Modification
10
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-family
PR:000027108
transcription adapter with TAZ, KIX and bromo-domains (human), h(CBP-p300)
Yes
PR:Q09472
histone acetyltransferase p300 (human),
PR:Q92793
CREB-binding protein (human),
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h(CBP-p300)
forms found in complexes
h(CBP-p300)
Component
Complexes
PR:000027108
h(CBP-p300)
PR:000027111
double-stranded RNA-activated factor 1 complex (human)
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000266
hCREBBP/var:R1378P
UniProtKB:Q92793, Arg-1378, CHEBI:50342 | UniProtKB:Q92793-1, Arg-1378, CHEBI:50342 | CREB-binding protein sequence variant 1 (human)
"A CREB-binding protein (human) that has a Pro residue at the position equivalent to Arg-1378 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342." [PMID:11331617, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:1933
Rubinstein-Taybi syndrome
PMID:11331617
enables
NOT
GO:0004402
histone acetyltransferase activity
PMID:11331617
located_in
SO:0001559
polypeptide_loss_of_function_variant
PMID:11331617
PR:Q92793-1
hCREBBP/iso:1
"A CREB-binding protein isoform 1 that is encoded in the genome of human." [PRO:CNA]
acts_upstream_of_or_within
GO:0006355
regulation of DNA-templated transcription
PMID:12169688
;
PMID:7913207
GO:0016573
histone acetylation
PMID:11742995
GO:0045893
positive regulation of DNA-templated transcription
PMID:11742995
enables
GO:0003713
transcription coactivator activity
PMID:10733899
;
PMID:10893273
;
PMID:12169688
;
PMID:12586840
;
PMID:8684459
GO:0004402
histone acetyltransferase activity
PMID:11742995
GO:0005515
protein binding
with
PR:P42858
HD
PMID:11799127
GO:0005515
protein binding
with
PR:P55209
hNAP1L1
PMID:11799127
GO:0005515
protein binding
with
PR:Q04206
hRELA
PMID:11799127
GO:0005515
protein binding
with
PR:Q14686
activating signal cointegrator 2 (human)
PMID:11799127
GO:0005515
protein binding
with
PR:Q16665
ARNT-interacting protein (human)
PMID:11799127
GO:0005515
protein binding
with
PR:Q92793
CBP
PMID:11799127
GO:0005515
protein binding
with
PR:Q99967-1
PMID:11799127
GO:0005515
protein binding
with
PR:Q9UER7
BING2
PMID:11799127
GO:0005515
protein binding
PMID:11799127
GO:0005515
protein binding
PMID:11799127
GO:0016407
acetyltransferase activity
PMID:11742995
located_in
GO:0000123
histone acetyltransferase complex
PMID:9742083
GO:0005634
nucleus
PMID:7913207