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RACE-PRO
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Documentation
Protein Ontology report - beclin-1 isoform 1
PR:000027468 -
http://purl.obolibrary.org/obo/PR_000027468
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000027468
PRO name
beclin-1 isoform 1
Synonyms
PRO-Short-label
:
EXACT:
BECN1/iso:1
Definition
"A beclin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:Q14457-1
or a 1:1 ortholog thereof." [PRO:CNA]
PRO Category
sequence
Parent
PR:000004719
beclin-1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
2
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000027468
beclin-1 isoform 1, BECN1/iso:1
organism-sequence
PR:O88597-1
beclin-1 isoform 1 (mouse), mBECN1/iso:1
organism-sequence
PR:Q14457-1
beclin-1 isoform 1 (human), hBECN1/iso:1
organism-modification
PR:000027471
beclin-1 isoform 1 phosphorylated 1 (human), hBECN1/iso:1/Phos:1
Yes
organism-modification
PR:000027487
beclin-1 isoform 1 unmodified form (human), hBECN1/iso:1/UnMod
modification
PR:000027470
beclin-1 isoform 1 phosphorylated 1, BECN1/iso:1/Phos:1
organism-modification
PR:000027471
beclin-1 isoform 1 phosphorylated 1 (human), hBECN1/iso:1/Phos:1
Yes
modification
PR:000027486
beclin-1 isoform 1 unmodified form, BECN1/iso:1/UnMod
organism-modification
PR:000027487
beclin-1 isoform 1 unmodified form (human), hBECN1/iso:1/UnMod
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027471
hBECN1/iso:1/Phos:1
UniProtKB:Q14457-1, Thr-119, MOD:00047
"A beclin-1 isoform 1 phosphorylated 1 in human. UniProtKB:Q14457-1, Thr-119, MOD:00047." [PMID:19180116, PMID:19395874, PRO:PD]
acts_upstream_of_or_within
GO:0010508
positive regulation of autophagy
PMID:19180116
;
PMID:19395874
enables
decreased
GO:0005515
protein binding
with
PR:P10415
BCL2
PMID:19180116
decreased
GO:0005515
protein binding
with
PR:Q07817-1
PMID:19180116