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Protein Ontology report - RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2
PR:000027472 -
http://purl.obolibrary.org/obo/PR_000027472
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000027472
PRO name
RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2
Synonyms
PRO-Short-label
:
EXACT:
AKT1/iso:1/Phos:2
Other
:
EXACT:
Akt1 autophosphorylated
Definition
"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form that is the actived form (see
PR:000003103
), which has been further phosphorylated by autocatalysis in trans at two sites that lie in the characteristic AKT substrate motif RxRxx[ST]. Example:
UniProtKB:P31749-1
, Thr-72/Thr-308,
MOD:00047
|Ser-246/Ser-473,
MOD:00046
." [
PMID:16549426
, PRO:PD]
PRO Category
modification
Parent
PR:000003102
RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000027472
RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2, AKT1/iso:1/Phos:2
organism-modification
PR:000027473
RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human), hAKT1/iso:1/Phos:2
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027473
hAKT1/iso:1/Phos:2
UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]
acts_upstream_of_or_within
GO:0043066
negative regulation of apoptotic process
PMID:16549426
