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Protein Ontology report - estrogen receptor isoform 1
PR:000027721 - http://purl.obolibrary.org/obo/PR_000027721
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000027721   
  PRO nameestrogen receptor isoform 1 
  Synonyms
PRO-Short-label: EXACT:ESR1/iso:1
  Definition"An estrogen receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-1 or a 1:1 ortholog thereof." [PMID:19940156, PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000007204 estrogen receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 1                                        
         Modification6                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000027721 estrogen receptor isoform 1, ESR1/iso:1

organism-sequence


PR:P03372-1 estrogen receptor isoform 1 (human), hESR1/iso:1

organism-modification


PR:000027724 estrogen receptor isoform 1 phosphorylated 1 (human), hESR1/iso:1/Phos:1
Yes
organism-modification


PR:000027726 estrogen receptor isoform 1 phosphorylated 2 (human), hESR1/iso:1/Phos:2
Yes
organism-modification


PR:000027754 estrogen receptor isoform 1 phosphorylated 3 (human), hESR1/iso:1/Phos:3

organism-modification


PR:000027756 estrogen receptor isoform 1 acetylated 1 (human), hESR1/iso:1/Ac:1
Yes
organism-modification


PR:000027776 estrogen receptor isoform 1 phosphorylated 4 (human), hESR1/iso:1/Phos:4
Yes
organism-modification


PR:000027778 estrogen receptor isoform 1 phosphorylated 5 (human), hESR1/iso:1/Phos:5

modification


PR:000027723 estrogen receptor isoform 1 phosphorylated 1, ESR1/iso:1/Phos:1

organism-modification


PR:000027724 estrogen receptor isoform 1 phosphorylated 1 (human), hESR1/iso:1/Phos:1
Yes
modification


PR:000027725 estrogen receptor isoform 1 phosphorylated 2, ESR1/iso:1/Phos:2

organism-modification


PR:000027726 estrogen receptor isoform 1 phosphorylated 2 (human), hESR1/iso:1/Phos:2
Yes
modification


PR:000027753 estrogen receptor isoform 1 phosphorylated 3, ESR1/iso:1/Phos:3

organism-modification


PR:000027754 estrogen receptor isoform 1 phosphorylated 3 (human), hESR1/iso:1/Phos:3

modification


PR:000027755 estrogen receptor isoform 1 acetylated 1, ESR1/iso:1/Ac:1

organism-modification


PR:000027756 estrogen receptor isoform 1 acetylated 1 (human), hESR1/iso:1/Ac:1
Yes
modification


PR:000027775 estrogen receptor isoform 1 phosphorylated 4, ESR1/iso:1/Phos:4

organism-modification


PR:000027776 estrogen receptor isoform 1 phosphorylated 4 (human), hESR1/iso:1/Phos:4
Yes
modification


PR:000027777 estrogen receptor isoform 1 phosphorylated 5, ESR1/iso:1/Phos:5

organism-modification


PR:000027778 estrogen receptor isoform 1 phosphorylated 5 (human), hESR1/iso:1/Phos:5

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027724 hESR1/iso:1/Phos:1
UniProtKB:P03372-1, Ser-167, MOD:00046 | phospho-ERalpha-Ser-167
"An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD]		 acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:19940156
PR:000027726 hESR1/iso:1/Phos:2
UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048
"An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]		 acts_upstream_of_or_withinGO:0010628 positive regulation of gene expression PMID:20101225
enablesGO:0042803 protein homodimerization activity PMID:20101225
located_inGO:0005634 nucleus PMID:20101225
PR:000027756 hESR1/iso:1/Ac:1
UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064 | AcK266/268-ERalpha (human) | ERalpha acetylated (human)
"An estrogen receptor isoform 1 acetylated 1 in human. UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]		 enablesGO:0003677 DNA binding PMID:16497729
PR:000027776 hESR1/iso:1/Phos:4
UniProtKB:P03372-1, Thr-311, MOD:00047 | pERalpha-Thr311
"An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]		 acts_upstream_of_or_withinGO:0010628 positive regulation of gene expression PMID:12138194
located_inGO:0005634 nucleus PMID:12138194