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RACE-PRO
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Protein Ontology report - estrogen receptor isoform 1 phosphorylated 1
PR:000027723 -
http://purl.obolibrary.org/obo/PR_000027723
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000027723
PRO name
estrogen receptor isoform 1 phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
ESR1/iso:1/Phos:1
Definition
"An estrogen receptor isoform 1 that has been phosphorylated at the Ser residue within the most C-terminal CK-2 phosphorylation consensus sequence S-x(2)-[DE] in the N-terminal activation function 1 (AF1) domain (
Pfam:PF02159
). This is one of the major phosphorylation sites needed for activation of the receptor. Example:
UniProtKB:P03372-1
, Ser-167,
MOD:00046
." [
Pfam:PF02159
,
PMID:19940156
, PRO:PD]
PRO Category
modification
Parent
PR:000027721
estrogen receptor isoform 1
PR:000037070
phosphoprotein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000027723
estrogen receptor isoform 1 phosphorylated 1, ESR1/iso:1/Phos:1
organism-modification
PR:000027724
estrogen receptor isoform 1 phosphorylated 1 (human), hESR1/iso:1/Phos:1
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027724
hESR1/iso:1/Phos:1
UniProtKB:P03372-1, Ser-167, MOD:00046 | phospho-ERalpha-Ser-167
"An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD]
acts_upstream_of_or_within
GO:0045893
positive regulation of DNA-templated transcription
PMID:19940156
