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RACE-PRO
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Protein Ontology report - estrogen receptor isoform 1 phosphorylated 2
PR:000027725 -
http://purl.obolibrary.org/obo/PR_000027725
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000027725
PRO name
estrogen receptor isoform 1 phosphorylated 2
Synonyms
PRO-Short-label
:
EXACT:
ESR1/iso:1/Phos:2
Definition
"An estrogen receptor isoform 1 that has been phosphorylated at the Tyr residue within the two YxxP motifs, on located in the N-terminal activation function 1 (AF1) domain (
Pfam:PF02159
), the other in the zf-C4 (
Pfam:PF00105
) domain. Example:
UniProtKB:P03372-1
, Tyr-52/Tyr-219,
MOD:00048
." [
PMID:20101225
, PRO:PD]
PRO Category
modification
Parent
PR:000027721
estrogen receptor isoform 1
PR:000037070
phosphoprotein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000027725
estrogen receptor isoform 1 phosphorylated 2, ESR1/iso:1/Phos:2
organism-modification
PR:000027726
estrogen receptor isoform 1 phosphorylated 2 (human), hESR1/iso:1/Phos:2
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027726
hESR1/iso:1/Phos:2
UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048
"An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]
acts_upstream_of_or_within
GO:0010628
positive regulation of gene expression
PMID:20101225
enables
GO:0042803
protein homodimerization activity
PMID:20101225
located_in
GO:0005634
nucleus
PMID:20101225
