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RACE-PRO
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Protein Ontology report - estrogen receptor isoform 1 phosphorylated 4
PR:000027775 -
http://purl.obolibrary.org/obo/PR_000027775
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000027775
PRO name
estrogen receptor isoform 1 phosphorylated 4
Synonyms
PRO-Short-label
:
EXACT:
ESR1/iso:1/Phos:4
Definition
"An estrogen receptor isoform 1 that has been phosphorylated on a Thr located in the helix 1 of the hormone binding domain. This highly conserved Thr residue is part of a leucine -rich nuclear export signal sequence and phosphorylation at this site blocks ERalpha nuclear export and promotes its transcriptional activation. Example:
UniProtKB:P03372-1
, Thr-311,
MOD:00047
." [
PMID:12138194
, PRO:PD]
PRO Category
modification
Parent
PR:000027721
estrogen receptor isoform 1
PR:000037070
phosphoprotein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000027775
estrogen receptor isoform 1 phosphorylated 4, ESR1/iso:1/Phos:4
organism-modification
PR:000027776
estrogen receptor isoform 1 phosphorylated 4 (human), hESR1/iso:1/Phos:4
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027776
hESR1/iso:1/Phos:4
UniProtKB:P03372-1, Thr-311, MOD:00047 | pERalpha-Thr311
"An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]
acts_upstream_of_or_within
GO:0010628
positive regulation of gene expression
PMID:12138194
located_in
GO:0005634
nucleus
PMID:12138194
