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Protein Ontology report - epidermal growth factor receptor, signal peptide removed form (human)
PR:000028422 - http://purl.obolibrary.org/obo/PR_000028422
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000028422   
  PRO nameepidermal growth factor receptor, signal peptide removed form (human) 
  Synonyms
PRO-Short-label: EXACT:hEGFR/SigPep-
PRO-proteoform-std: EXACT:UniProtKB:P00533, 25-1210
NARROW:UniProtKB:P00533-1, 25-1210
Other: NARROW:PRO_0000016665
  Definition"An epidermal growth factor receptor, signal peptide removed form in human. Example: UniProtKB:P00533-1, 25-1210." [PRO:DNx] 
  PRO Categoryorganism-modification 
  ParentPR:000019753 epidermal growth factor receptor, signal peptide removed form
PR:P00533 epidermal growth factor receptor (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification0                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-modification


PR:000028422 epidermal growth factor receptor, signal peptide removed form (human), hEGFR/SigPep-

Yes
organism-modification


PR:000027477 epidermal growth factor receptor isoform 1, signal peptide removed form (human), hEGFR/iso:1/SigPep-

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
organism-modification


PR:000047261 epidermal growth factor receptor, signal peptide removed phosphorylated 1 (human), hEGFR/SigPep-/Phos:1

organism-modification


PR:000047262 epidermal growth factor receptor, signal peptide removed phosphorylated 2 (human), hEGFR/SigPep-/Phos:2

organism-modification


PR:000049849 epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human), hEGFR/SigPep-/Phos:3
Yes
organism-modification


PR:000049850 epidermal growth factor receptor, signal peptide removed unphosphorylated 3 (human), hEGFR/SigPep-/UnPhos:3

organism-modification


PR:000049851 epidermal growth factor receptor, signal peptide removed phosphorylated 4 (human), hEGFR/SigPep-/Phos:4
Yes
organism-modification


PR:000049852 epidermal growth factor receptor, signal peptide removed unphosphorylated 4 (human), hEGFR/SigPep-/UnPhos:4

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hEGFR/SigPep- forms found in complexes   

hEGFR/SigPep- Component
 Complexes
PR:000028422 hEGFR/SigPep- PR:000028451 L1-EGFR trans-heterodimer (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027479 hEGFR/iso:1/SigPep-/Phos:1
UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048 | PRO_0000016665, Tyr-869, MOD:00048
"An epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048." [PMID:18789131, PRO:PD]		 acts_upstream_of_or_withinGO:0034504 protein localization to nucleus PMID:18789131
located_inGO:0005634 nucleus PMID:18789131
PR:000049849 hEGFR/SigPep-/Phos:3
UniProtKB:P00533, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046 | UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046
"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046." [PMID:10347170, PRO:KER]		 enablesdecreased GO:0004713 protein tyrosine kinase activity relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
decreased GO:0005515 protein binding relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
PR:000049851 hEGFR/SigPep-/Phos:4
UniProtKB:P00533, 25-1210, Ser-768, MOD:00046 | UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046
"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-768 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046." [PMID:10347170, PRO:KER]		 enablesdecreased GO:0004713 protein tyrosine kinase activity relative to PR:000049852 hEGFR/SigPep-/UnPhos:4 PMID:10347170