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Protein Ontology report - pro-neuregulin-1, membrane-bound isoform
PR:000029649 - http://purl.obolibrary.org/obo/PR_000029649
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000029649   
  PRO namepro-neuregulin-1, membrane-bound isoform 
  Synonyms
PRO-Short-label: EXACT:NRG1
Gene-based: RELATED:GGF | HGL | HRGA | NDF | SMDF
Other: EXACT:acetylcholine receptor inducing activity | glial growth factor | heregulin | neu differentiation factor | pro-NRG1 | sensory and motor neuron derived factor
  Definition"A protein that is a translation product of the human NRG1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence7                                                  Organism-Sequence 35                                        
         Modification2                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000029649 pro-neuregulin-1, membrane-bound isoform, NRG1


organism-gene



PR:P43322 pro-neuregulin-1, membrane-bound isoform (rat), rNRG1


organism-sequence



PR:P43322-1 neuregulin-1 type I-beta4a (rat), rNRG1/iso:Ibeta4a


organism-sequence



PR:G3V7F0 neuregulin-1 type I-beta4a sequence variant V386I (rat), rNRG1/iso:Ibeta4a/var:V386I


organism-sequence



PR:P43322-2 pro-neuregulin-1, membrane-bound isoform isoform rAlpha2A (rat), rNRG1/iso:rAlpha2A


organism-sequence



PR:P43322-3 pro-neuregulin-1, membrane-bound isoform isoform rAlpha2B (rat), rNRG1/iso:rAlpha2B


organism-sequence



PR:P43322-4 pro-neuregulin-1, membrane-bound isoform isoform rAlpha2C (rat), rNRG1/iso:rAlpha2C


organism-sequence



PR:P43322-5 neuregulin-1 type I-beta1a (rat), rNRG1/iso:Ibeta1a


organism-sequence



PR:P43322-6 pro-neuregulin-1, membrane-bound isoform isoform rBeta2 (rat), rNRG1/iso:rBeta2


organism-sequence



PR:P43322-7 pro-neuregulin-1, membrane-bound isoform isoform rBetA2A (rat), rNRG1/iso:rBetA2A


organism-sequence



PR:P43322-8 pro-neuregulin-1, membrane-bound isoform isoform rBeta3 (rat), rNRG1/iso:rBeta3


organism-sequence



PR:Q3S2T6 neuregulin-1 type III-beta3 (rat), rNRG1/iso:IIIbeta3


organism-gene



PR:Q02297 pro-neuregulin-1, membrane-bound isoform (human), hNRG1


organism-sequence



PR:A0A494C1B5 neuregulin-1 type III-beta1c (human), hNRG1/iso:IIIbeta1c


organism-sequence



PR:Q02297-1 neuregulin-1 type I-alpha2a (human), hNRG1/iso:Ialpha2a


organism-sequence



PR:Q02297-10 neuregulin-1 type III-beta3 (human), hNRG1/iso:IIIbeta3


organism-sequence



PR:Q02297-11 pro-neuregulin-1, membrane-bound isoform isoform h11 (human), hNRG1/iso:h11


organism-sequence



PR:Q02297-12 pro-neuregulin-1, membrane-bound isoform isoform h12 (human), hNRG1/iso:h12


organism-sequence



PR:Q02297-2 pro-neuregulin-1, membrane-bound isoform isoform h2 (human), hNRG1/iso:h2


organism-sequence



PR:Q02297-3 pro-neuregulin-1, membrane-bound isoform isoform h3 (human), hNRG1/iso:h3


organism-sequence



PR:Q02297-4 pro-neuregulin-1, membrane-bound isoform isoform h4 (human), hNRG1/iso:h4


organism-sequence



PR:Q02297-6 neuregulin-1 type I-beta1a (human), hNRG1/iso:Ibeta1a


organism-sequence



PR:Q02297-7 neuregulin-1 type beta2 (human), hNRG1/iso:beta2


organism-sequence



PR:Q02297-8 pro-neuregulin-1, membrane-bound isoform isoform h8 (human), hNRG1/iso:h8


organism-sequence



PR:Q02297-9 pro-neuregulin-1, membrane-bound isoform isoform h9 (human), hNRG1/iso:h9


organism-gene



PR:Q05199 pro-neuregulin-1, membrane-bound isoform (chicken), chick-NRG1


organism-sequence



PR:Q05199-1 pro-neuregulin-1, membrane-bound isoform isoform 1 (chicken), chick-NRG1/iso:1


organism-sequence



PR:Q05199-2 pro-neuregulin-1, membrane-bound isoform isoform 2 (chicken), chick-NRG1/iso:2


organism-sequence



PR:Q05199-3 pro-neuregulin-1, membrane-bound isoform isoform 3 (chicken), chick-NRG1/iso:3


organism-sequence



PR:Q05199-4 pro-neuregulin-1, membrane-bound isoform isoform 4 (chicken), chick-NRG1/iso:4


organism-gene



PR:Q6DR98 pro-neuregulin-1, membrane-bound isoform (mouse), mNRG1

Yes

organism-sequence



PR:000044837 neuregulin-1 type I-beta4a (mouse), mNRG1/iso:Ibeta4a


organism-modification



PR:000044838 neuregulin-1 type I-beta4a transmembrane precursor (mouse), mNRG1/iso:Ibeta4a/precursor


organism-modification



PR:000044839 neuregulin-1 type I-beta4a mature form (mouse), mNRG1/iso:Ibeta4a/mature


union



PR:000044840 neuregulin-1 type III (mouse), mNRG1/iso:III

Yes





PR:A0A140LIG9 ,






PR:A0A5F8MPT0 ,






PR:Q6DR99 ,


organism-sequence



PR:A0A140LIG9 neuregulin-1 type III-beta1c (mouse), mNRG1/iso:IIIbeta1c


organism-sequence



PR:Q3URY7 neuregulin-1 type III-beta1c sequence variant S499Y (mouse), mNRG1/iso:IIIbeta1c/var:S499Y


organism-modification



PR:000044825 neuregulin-1 type III-beta1c transmembrane precursor (mouse), mNRG1/iso:IIIbeta1c/precursor


organism-sequence



PR:A0A140LIP8 neuregulin-1 type beta2 (mouse), mNRG1/iso:beta2


organism-sequence



PR:A0A140LJC1 neuregulin-1 type I-alpha2a (mouse), mNRG1/iso:Ialpha2a


organism-modification



PR:000044842 neuregulin-1 type I-alpha2a transmembrane precursor (mouse), mNRG1/iso:Ialpha2a/precursor


organism-sequence



PR:A0A5F8MPT0 neuregulin-1 type III-beta3 (mouse), mNRG1/iso:IIIbeta3


organism-sequence



PR:Q8BX76 neuregulin-1 type III-beta3 sequence variant D40N (mouse), mNRG1/iso:IIIbeta3/var:D40N


organism-sequence



PR:Q6DR98-1 neuregulin-1 type I-beta1a (mouse), mNRG1/iso:Ibeta1a


organism-modification



PR:000044821 neuregulin-1 type I-beta1a mature form (mouse), mNRG1/iso:Ibeta1a/mature

Yes

organism-modification



PR:000044823 neuregulin-1 type I-beta1a transmembrane precursor (mouse), mNRG1/iso:Ibeta1a/precursor


organism-sequence



PR:Q6DR99 neuregulin-1 type III-beta1a (mouse), mNRG1/iso:IIIbeta1a

Yes

organism-modification



PR:000044824 neuregulin-1 type III-beta1a transmembrane precursor (mouse), mNRG1/iso:IIIbeta1a/precursor

Yes

organism-modification



PR:000044843 neuregulin-1 intracellular domain (mouse), mNRG1/Clv:intracellular

Yes

sequence



PR:000044820 neuregulin-1 type I-beta1a, NRG1/iso:Ibeta1a


organism-sequence



PR:P43322-5 neuregulin-1 type I-beta1a (rat), rNRG1/iso:Ibeta1a


organism-sequence



PR:Q02297-6 neuregulin-1 type I-beta1a (human), hNRG1/iso:Ibeta1a


organism-sequence



PR:Q6DR98-1 neuregulin-1 type I-beta1a (mouse), mNRG1/iso:Ibeta1a


organism-modification



PR:000044821 neuregulin-1 type I-beta1a mature form (mouse), mNRG1/iso:Ibeta1a/mature

Yes

organism-modification



PR:000044823 neuregulin-1 type I-beta1a transmembrane precursor (mouse), mNRG1/iso:Ibeta1a/precursor


sequence



PR:000044822 neuregulin-1 type III-beta3, NRG1/iso:IIIbeta3


organism-sequence



PR:A0A5F8MPT0 neuregulin-1 type III-beta3 (mouse), mNRG1/iso:IIIbeta3


organism-sequence



PR:Q8BX76 neuregulin-1 type III-beta3 sequence variant D40N (mouse), mNRG1/iso:IIIbeta3/var:D40N


organism-sequence



PR:Q02297-10 neuregulin-1 type III-beta3 (human), hNRG1/iso:IIIbeta3


organism-sequence



PR:Q3S2T6 neuregulin-1 type III-beta3 (rat), rNRG1/iso:IIIbeta3


sequence



PR:000060231 neuregulin-1 type I-alpha2a, NRG1/iso:Ialpha2a


organism-sequence



PR:A0A140LJC1 neuregulin-1 type I-alpha2a (mouse), mNRG1/iso:Ialpha2a


organism-modification



PR:000044842 neuregulin-1 type I-alpha2a transmembrane precursor (mouse), mNRG1/iso:Ialpha2a/precursor


organism-sequence



PR:Q02297-1 neuregulin-1 type I-alpha2a (human), hNRG1/iso:Ialpha2a


sequence



PR:000060232 neuregulin-1 type III-beta1c, NRG1/iso:IIIbeta1c


organism-sequence



PR:A0A140LIG9 neuregulin-1 type III-beta1c (mouse), mNRG1/iso:IIIbeta1c


organism-sequence



PR:Q3URY7 neuregulin-1 type III-beta1c sequence variant S499Y (mouse), mNRG1/iso:IIIbeta1c/var:S499Y


organism-modification



PR:000044825 neuregulin-1 type III-beta1c transmembrane precursor (mouse), mNRG1/iso:IIIbeta1c/precursor


organism-sequence



PR:A0A494C1B5 neuregulin-1 type III-beta1c (human), hNRG1/iso:IIIbeta1c


sequence



PR:000060233 neuregulin-1 type beta2, NRG1/iso:beta2


organism-sequence



PR:A0A140LIP8 neuregulin-1 type beta2 (mouse), mNRG1/iso:beta2


organism-sequence



PR:Q02297-7 neuregulin-1 type beta2 (human), hNRG1/iso:beta2


sequence



PR:000060238 neuregulin-1 type I-alpha2b, NRG1/iso:Ialpha2b


sequence



PR:000060239 neuregulin-1 type I-beta3, NRG1/iso:Ibeta3


modification



PR:000029650 pro-neuregulin-1, membrane-bound isoform, initiator methionine removed form, NRG1/InitMet-


modification



PR:000029651 pro-neuregulin-1, membrane-bound isoform proteolytic cleavage product, NRG1/ClvPrd


organism-modification



PR:000044821 neuregulin-1 type I-beta1a mature form (mouse), mNRG1/iso:Ibeta1a/mature

Yes

organism-modification



PR:000044839 neuregulin-1 type I-beta4a mature form (mouse), mNRG1/iso:Ibeta4a/mature


organism-modification



PR:000044843 neuregulin-1 intracellular domain (mouse), mNRG1/Clv:intracellular

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044821
mNRG1/iso:Ibeta1a/mature
neuregulin beta1a mature form (mouse) | NRG beta1a mature form (mouse)
acts_upstream_of_or_withinGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI:3625788; PMID:11116142
located_inGO:0005576 extracellular region MGI:3625788; PMID:11116142
PR:000044824
mNRG1/iso:IIIbeta1a/precursor
neuregulin type III-beta1a precursor (mouse) | NRG type III-beta1a precursor (mouse)
acts_upstream_of_or_withinGO:0045773 positive regulation of axon extension MGI:4461331; PMID:20610754
PR:000044840
mNRG1/iso:III
acts_upstream_of_or_withinGO:0001964 startle response MGI:3803029; PMID:18596162
GO:0008366 axon ensheathment MGI:3590355; PMID:16129398
GO:0031643 positive regulation of myelination MGI:4420197; PMID:18080294
GO:0031643 positive regulation of myelination MGI:4420197; PMID:18080294
NOT GO:0048709 oligodendrocyte differentiation MGI:4420197; PMID:18080294
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction MGI:3796800; PMID:18458158
GO:0060999 positive regulation of dendritic spine development MGI:4461331; PMID:20610754
GO:0060999 positive regulation of dendritic spine development MGI:4461331; PMID:20610754
GO:2000010 positive regulation of protein localization to cell surface MGI:3796800; PMID:18458158
located_inGO:0030424 axon MGI:4461331; PMID:20610754
GO:0030424 axon MGI:4461331; PMID:20610754
GO:0030425 dendrite MGI:4461331; PMID:20610754
GO:0030673 axolemma MGI:3796800; PMID:18458158
GO:0044297 cell body MGI:4461331; PMID:20610754
PR:000044843
mNRG1/Clv:intracellular
UniProtKB:Q6DR99, 326-700 | NRG1 ICD (mouse)
acts_upstream_of_or_withinGO:0022008 neurogenesis MGI:4438553; PMID:19781646
GO:0022008 neurogenesis MGI:4438553; PMID:19781646
NOT GO:0045773 positive regulation of axon extension MGI:4461331; PMID:20610754
GO:0045944 positive regulation of transcription by RNA polymerase II MGI:4461331; PMID:20610754
enablesGO:0005515 protein binding with PR:O54941 Baf57 MGI:4438553; PMID:19781646
located_inGO:0005634 nucleus MGI:4461331; PMID:20610754
PR:Q6DR98
mNRG1
Nrg1 | pro-NRG1 (mouse)
acts_upstream_of_or_withinNOT GO:0031643 positive regulation of myelination MGI:3042336; PMID:15044753
located_inGO:0009897 external side of plasma membrane MGI:3625788; PMID:11116142
PR:Q6DR99
mNRG1/iso:IIIbeta1a
neuregulin-1 type III beta1-a (mouse)
acts_upstream_of_or_withinGO:0031643 positive regulation of myelination MGI:3042336; PMID:15044753