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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human) PR:000035428 - http://purl.obolibrary.org/obo/PR_000035428        Complex   Annotations       Ontology Information Show OBO stanza / PAF / GPI   PRO ID PR:000035428      PRO name mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)    Synonyms PRO-Short-label: EXACT: hBUB1B/Phos:2 PRO-proteoform-std: NARROW: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047) Other: RELATED: BUBR1 phosphorylated (human) | hBUBR1 phosphorylated   Definition "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER]    Comment Note: This phosphorylated form is observed during pro metaphase, spindle depolymerization (nocodazole), and lack of kinetochore tension (taxol). Kinase=("CDK1"; PR:000003271; Thr-620). Kinase=("PLK1"; PR:P53350; Ser-676/Thr-680).    PRO Category organism-modification    Parent PR:000035427 mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)   Taxon NCBITaxon:9606 Homo sapiens   Term Hierarchy   Visualization DAG: OLS: Back to top hBUB1B/Phos:2 forms found in complexes    hBUB1B/Phos:2 Component Complexes PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human) Back to top Functional Annotation (PRO-centric view) Switch to GO Centric View    PRO Term GO Annotation Evidence PR:000035428 hBUB1B/Phos:2 UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047) | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER] acts_upstream_of_or_within GO:0006974 DNA damage response PMID:18440313 increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528 increased GO:0051310 metaphase chromosome alignment relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779; PMID:17785528 enables increased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779 increased GO:0005515 protein binding with PR:O43683 BUB1 PMID:23079597 increased GO:0005515 protein binding with PR:Q15172 hPPP2R5A PMID:23079597 increased GO:0005515 protein binding relative to PR:000035425 frog-BUB1B/PhosRes- PMID:23079597 located_in GO:0000776 kinetochore PMID:17785528