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Protein Ontology report - IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR3/TLR4 complex (human)
PR:000036180 -
http://purl.obolibrary.org/obo/PR_000036180
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000036180
PRO name
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR3/TLR4 complex (human)
Synonyms
Other
:
EXACT:
activated TLR3/TLR4:TRIF:K63-pUb-RIP1:IKKcomplex (human)
Definition
"A protein-containing complex in human that is composed of Ticam2 (TRAM), Ticam1 (TRIF), the death receptor RIPK1 (RIP1) cross-linked to K63-linked polyubiquitin, the IKK complex (consisting of IKKA, IKKB and NEMO), and either activated Toll-like receptor 4 (TLR4) or activated Toll-like receptor 3 (TLR3)." [PRO:DAN,
Reactome:R
-HSA-937030]
PRO Category
organism-complex
Parent
G0032991
protein-containing complex
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Complex
0
Organism-Complex
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-complex
PR:000036180
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR3/TLR4 complex (human), hACTB/Ac:1
organism-complex
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human), hRIPK1/K63polyUbiq:1
organism-complex
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human), ARAP3/iso:1
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036053
hRIPK1/K63polyUbiq:1
activated TLR4:TRIF:K63-pUb-RIP1:IKKcomplex (human)
"An IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [PMID:15064760, PMID:15814722, PMID:16115877, Reactome:R-HSA-937030]
acts_upstream_of_or_within
GO:0002756
MyD88-independent toll-like receptor signaling pathway
Reactome:REACT_6809
located_in
GO:0010008
endosome membrane
Reactome:REACT_26016
PR:000037364
ARAP3/iso:1
activated TLR3:TRIF:K63-pUb-RIP1:IKKcomplex (human)
"An IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex whose components are encoded in the genome of human." [PMID:15064760, PMID:15814722, PMID:16115877, Reactome:R-HSA-937030]
acts_upstream_of_or_within
GO:0002756
MyD88-independent toll-like receptor signaling pathway
Reactome:REACT_6783
GO:0034138
toll-like receptor 3 signaling pathway
Reactome:REACT_6783
located_in
GO:0010008
endosome membrane
Reactome:REACT_6783
