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Protein Ontology report - NS345
PR:000036839 - http://purl.obolibrary.org/obo/PR_000036839
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036839   
  PRO nameNS345 
  Synonyms
PRO-Short-label: EXACT:DenV-NS345
Other: EXACT:NS3-NS4A-NS4B-NS5
  Definition"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component proteinase NS2B-NS3 at the NS2B-NS3 site consisting of NS3, NS4A, NS4B, and NS5." [PMID:1433530, PRO:ES] 
  CommentRequested by=IDODEN. Cleavage at the NS2A-NS2B site was also mediated by the NS2B-NS3 protease, while the NS1-NS2A site was mediated by host cell-derived protease. 
  PRO Categorymodification 
  ParentPR:000036818
PR:000036838
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification8                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
modification



PR:000036839 NS345, DenV-NS345


modification



PR:000036828 NS3, DenV-NS3


Yes
organism-modification



PR:000044762 NS3 (Dengue virus 2 Thailand/NGS-C/1944), NS3 (DEN2N)

Yes

modification



PR:000036840 NS4A-NS4B-NS5, DenV-NS4AB5


modification



PR:000036841 NS4AB, DenV-NS4AB


modification



PR:000036830 NS4A, DenV-NS4A


organism-modification



PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)

Yes

organism-modification



PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)

Yes

modification



PR:000036842 2KNS4B, DenV-2KNS4B


modification



PR:000036831 2K, DenV-2K


organism-modification



PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)

Yes

modification



PR:000036843 NS4B-NS5, DenV-NS4B5


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DenV-NS345 forms found in complexes   

DenV-NS345 Component
Complexes
PR:000036828 DenV-NS3 PR:000036829
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044762
NS3 (DEN2N)
UniProtKB:P14340, 1476-2093 | PRO_0000037965
acts_upstream_of_or_withinGO:0019082 viral protein processing PMID:10744671
enablesGO:0003724 RNA helicase activity PMID:10744671
GO:0008236 serine-type peptidase activity PMID:10744671
GO:0017111 ribonucleoside triphosphate phosphatase activity PMID:10744671
PR:000044763
NS4A (DEN2N)
UniProtKB:P14340, 2094-2220 | PRO_0000037966
acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:17276984
located_inGO:0019034 viral replication complex PMID:17276984
PR:000044764
NS4A (DEN26)
UniProtKB:P29990, 2094-2220 | PRO_0000037933
acts_upstream_of_or_withinGO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044765
2K (DEN2N)
UniProtKB:P14340, 2221-2243 | PRO_0000261391
acts_upstream_of_or_withinGO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence PMID:17276984
enablesGO:0043495 protein-membrane adaptor activity PMID:21810535
located_inGO:0016020 membrane PMID:21810535