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RACE-PRO
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Documentation
Protein Ontology report - NS345
PR:000036839 -
http://purl.obolibrary.org/obo/PR_000036839
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000036839
PRO name
NS345
Synonyms
PRO-Short-label
:
EXACT:
DenV-NS345
Other
:
EXACT:
NS3-NS4A-NS4B-NS5
Definition
"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component proteinase NS2B-NS3 at the NS2B-NS3 site consisting of NS3, NS4A, NS4B, and NS5." [
PMID:1433530
, PRO:ES]
Comment
Requested by=IDODEN. Cleavage at the NS2A-NS2B site was also mediated by the NS2B-NS3 protease, while the NS1-NS2A site was mediated by host cell-derived protease.
PRO Category
modification
Parent
PR:000036818
PR:000036838
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
8
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000036839
NS345, DenV-NS345
modification
PR:000036828
NS3, DenV-NS3
Yes
organism-modification
PR:000044762
NS3 (Dengue virus 2 Thailand/NGS-C/1944), NS3 (DEN2N)
Yes
modification
PR:000036840
NS4A-NS4B-NS5, DenV-NS4AB5
modification
PR:000036841
NS4AB, DenV-NS4AB
modification
PR:000036830
NS4A, DenV-NS4A
organism-modification
PR:000044763
NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification
PR:000044764
NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification
PR:000036842
2KNS4B, DenV-2KNS4B
modification
PR:000036831
2K, DenV-2K
organism-modification
PR:000044765
2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification
PR:000036843
NS4B-NS5, DenV-NS4B5
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DenV-NS345
forms found in complexes
DenV-NS345
Component
Complexes
PR:000036828
DenV-NS3
PR:000036829
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000044762
NS3 (DEN2N)
UniProtKB:P14340, 1476-2093 | PRO_0000037965
acts_upstream_of_or_within
GO:0019082
viral protein processing
PMID:10744671
enables
GO:0003724
RNA helicase activity
PMID:10744671
GO:0008236
serine-type peptidase activity
PMID:10744671
GO:0017111
ribonucleoside triphosphate phosphatase activity
PMID:10744671
PR:000044763
NS4A (DEN2N)
UniProtKB:P14340, 2094-2220 | PRO_0000037966
acts_upstream_of_or_within
GO:0019079
viral genome replication
PMID:17276984
located_in
GO:0019034
viral replication complex
PMID:17276984
PR:000044764
NS4A (DEN26)
UniProtKB:P29990, 2094-2220 | PRO_0000037933
acts_upstream_of_or_within
GO:0060339
negative regulation of type I interferon-mediated signaling pathway
PMID:14612562
PR:000044765
2K (DEN2N)
UniProtKB:P14340, 2221-2243 | PRO_0000261391
acts_upstream_of_or_within
GO:0045051
protein insertion into ER membrane by internal uncleaved signal-anchor sequence
PMID:17276984
enables
GO:0043495
protein-membrane adaptor activity
PMID:21810535
located_in
GO:0016020
membrane
PMID:21810535