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Protein Ontology report - CD14 molecule cleaved 2 (human)
PR:000037480 - http://purl.obolibrary.org/obo/PR_000037480
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000037480   
  PRO nameCD14 molecule cleaved 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hCD14/Clv:2
PRO-proteoform-std: EXACT:UniProtKB:P08571, 20-345
Other: EXACT:PRO_0000020885
RELATED:CD14 molecule (human)
  Definition"A CD14 molecule cleaved 2 in human. This represents both the GPI-anchored and soluble forms. UniProtKB:P08571, 20-345." [PRO:CNA, PRO:DAN] 
  PRO Categoryorganism-modification 
  ParentPR:000036848 CD14 molecule cleaved 2
PR:P08571 monocyte differentiation antigen CD14 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-modification


PR:000037480 CD14 molecule cleaved 2 (human), hCD14/Clv:2

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human), hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble
Yes
Yes
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hCD14/Clv:2 forms found in complexes   

hCD14/Clv:2 Component
 Complexes
PR:000035702 hCD14/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000037480 hCD14/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035702 hCD14/Clv:2/anchored
UniProtKB:P08571, 20-345, Asn-345, MOD:00167 | GPI-anchored form of CD14 (human) | GPI-N345-CD14 (human) | PRO_0000020885, Asn-345, MOD:00167
"A CD14 molecule cleaved 2 GPI-anchored form in human. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_inGO:0005886 plasma membrane Reactome:REACT_7740
GO:0005886 plasma membrane Reactome:REACT_7740
PR:000035703 hCD14/Clv:2/soluble
Secreted form of CD14 (human)
"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
enablesGO:0001530 lipopolysaccharide binding PMID:9464818
located_inCL:0000129 microglial cell PMID:24659539
GO:0005576 extracellular region PMID:2779588; PMID:9665271