back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - cathepsin-like protease
PR:000040662 - http://purl.obolibrary.org/obo/PR_000040662
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000040662   
  PRO namecathepsin-like protease 
  Synonyms
PRO-Short-label: EXACT:fam:CTS
Other: NARROW:cathepsin
  Definition"A protein that is a translation product of some metazoan gene that encodes a signal peptide followed by a single Cathepsin propeptide inhibitor domain (Pfam:PF08246) followed by a single Papain family cysteine protease (Pfam:PF00112) domain at the C terminus." [PRO:DAN] 
  PRO Categoryfamily 
  ParentPR:000036194 eukaryotic protein
  TaxonNCBITaxon:33208 Metazoa
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene18                                                  Organism-Gene 59                                        
         Sequence12                                                  Organism-Sequence 32                                        
         Modification22                                                  Organism-Modification 35                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000040662 cathepsin-like protease, fam:CTS

gene


PR:000001850 cathepsin K, CTSK

organism-gene


PR:O35186 cathepsin K (rat), rCTSK

organism-sequence


PR:O35186-1 cathepsin K isoform 1 (rat), rCTSK/iso:1

organism-gene


PR:P43235 cathepsin K (human), hCTSK

organism-sequence


PR:P43235-1 cathepsin K isoform 1 (human), hCTSK/iso:1

organism-gene


PR:P43236 cathepsin K (rabbit), rabbit-CTSK

organism-gene


PR:P55097 cathepsin K (mouse), mCTSK

organism-sequence


PR:P55097-1 cathepsin K isoform 1 (mouse), mCTSK/iso:1

organism-gene


PR:Q3ZKN1 cathepsin K (dog), dog-CTSK

organism-gene


PR:Q9STL4 KDEL-tailed cysteine endopeptidase CEP2 (Arabidopsis thaliana), At-CTSK

sequence


PR:000039460 cathepsin K isoform 1, CTSK/iso:1

organism-sequence


PR:O35186-1 cathepsin K isoform 1 (rat), rCTSK/iso:1

organism-sequence


PR:P43235-1 cathepsin K isoform 1 (human), hCTSK/iso:1

organism-sequence


PR:P55097-1 cathepsin K isoform 1 (mouse), mCTSK/iso:1

modification


PR:000018547 cathepsin K proteolytic cleavage product, CTSK/ClvPrd

gene


PR:000006023 cathepsin B, CTSB

organism-gene


PR:P00787 cathepsin B (rat), rCTSB

organism-gene


PR:P07688 cathepsin B (cow), cow-CTSB

organism-gene


PR:P07858 cathepsin B (human), hCTSB

organism-sequence


PR:P07858-1 cathepsin B isoform 1 (human), hCTSB/iso:1

organism-modification


PR:000065779 cathepsin B deaminated 1 (human), hCTSB/Deam:1

organism-modification


PR:000069475 cathepsin B cysteinylated 1 (human), hCTSB/Cyst:1

organism-gene


PR:P10605 cathepsin B (mouse), mCTSB

organism-sequence


PR:P10605-1 cathepsin B isoform 1 (mouse), mCTSB/iso:1

organism-gene


PR:Q54QD9 cathepsin B (Dictyostelium discoideum), Dicty-CTSB

organism-gene


PR:Q93VC9 cathepsin B-like protease 2 (Arabidopsis thaliana), At-CTSB

organism-gene


PR:Q9VY87 cathepsin B1, isoform A (fruit fly), fly-CTSB

sequence


PR:000038720 cathepsin B isoform 1, CTSB/iso:1

organism-sequence


PR:P07858-1 cathepsin B isoform 1 (human), hCTSB/iso:1

organism-sequence


PR:P10605-1 cathepsin B isoform 1 (mouse), mCTSB/iso:1

modification


PR:000019555 cathepsin B proteolytic cleavage product, CTSB/ClvPrd

gene


PR:000006025 cathepsin D, CTSD

organism-gene


PR:O76856 cathepsin D (Dictyostelium discoideum), Dicty-CTSD

organism-gene


PR:P07339 cathepsin D (human), hCTSD

organism-modification


PR:000053727 cathepsin D O-glycosylated 1 (human), hCTSD/OGlyco:1

organism-modification


PR:000065667 cathepsin D glutathionylated 1 (human), hCTSD/SGlt:1

organism-modification


PR:000074474 cathepsin D cysteinylated 1 (human), hCTSD/Cyst:1

organism-modification


PR:000076876 cathepsin D cysteinylated 2 (human), hCTSD/Cyst:2

organism-modification


PR:000079343 cathepsin D deaminated 1 (human), hCTSD/Deam:1

organism-modification


PR:000085149 cathepsin D cysteinylated 3 (human), hCTSD/Cyst:3

organism-gene


PR:P18242 cathepsin D (mouse), mCTSD

organism-gene


PR:P24268 cathepsin D (rat), rCTSD

organism-modification


PR:000058851 cathepsin D N-glycosylated 1 (rat), rCTSD/NGlyco:1

organism-modification


PR:000058852 cathepsin D N-glycosylated 2 (rat), rCTSD/NGlyco:2

organism-modification


PR:000058853 cathepsin D N-glycosylated 3 (rat), rCTSD/NGlyco:3

organism-modification


PR:000058854 cathepsin D N-glycosylated 4 (rat), rCTSD/NGlyco:4

organism-modification


PR:000058855 cathepsin D N-glycosylated 5 (rat), rCTSD/NGlyco:5

organism-modification


PR:000058856 cathepsin D N-glycosylated 6 (rat), rCTSD/NGlyco:6

organism-gene


PR:P32834 aspartic proteinase sxa1 (Schizosaccharomyces pombe 972h-), Spom972h-CTSD

organism-gene


PR:Q05744 cathepsin D (chicken), chick-CTSD

organism-gene


PR:Q21966 aspartic protease 4 (worm), CTSD (worm)

modification


PR:000019560 cathepsin D, signal peptide removed form, CTSD/SigPep-

modification


PR:000019561 cathepsin D proteolytic cleavage product, CTSD/ClvPrd

gene


PR:000006026 cathepsin E, CTSE

organism-gene


PR:P14091 cathepsin E (human), hCTSE

organism-sequence


PR:P14091-1 cathepsin E isoform h1 (human), hCTSE/iso:h1

organism-sequence


PR:P14091-2 cathepsin E isoform h2 (human), hCTSE/iso:h2

organism-sequence


PR:P14091-3 cathepsin E isoform h3 (human), hCTSE/iso:h3

organism-modification


PR:000083474 cathepsin E phosphorylated 1 (human), hCTSE/Phos:1

organism-gene


PR:P16228 cathepsin E (rat), rCTSE

organism-sequence


PR:P16228-1 cathepsin E isoform r1 (rat), rCTSE/iso:r1

organism-sequence


PR:P16228-2 cathepsin E isoform r2 (rat), rCTSE/iso:r2

organism-gene


PR:P55956 aspartic protease 3 (worm), CTSE (worm)

organism-gene


PR:P70269 cathepsin E (mouse), mCTSE

modification


PR:000019563 cathepsin E, signal peptide removed form, CTSE/SigPep-

modification


PR:000019564 cathepsin E proteolytic cleavage product, CTSE/ClvPrd

gene


PR:000006027 cathepsin F, CTSF

organism-gene


PR:Q8VYS0 probable cysteine protease RD19D (Arabidopsis thaliana), At-CTSF

organism-gene


PR:Q9R013 cathepsin F (mouse), mCTSF

organism-gene


PR:Q9UBX1 cathepsin F (human), hCTSF

organism-gene


PR:Q9VN93 putative cysteine proteinase CG12163 (fruit fly), fly-CTSF

organism-sequence


PR:Q9VN93-1 putative cysteine proteinase CG12163 isoform A (fruit fly), fly-CTSF/iso:A

organism-sequence


PR:Q9VN93-2 putative cysteine proteinase CG12163 isoform B (fruit fly), fly-CTSF/iso:B

modification


PR:000019565 cathepsin F proteolytic cleavage product, CTSF/ClvPrd

gene


PR:000006028 cathepsin G, CTSG

organism-gene


PR:P08311 cathepsin G (human), hCTSG

organism-modification


PR:000035925 cathepsin G cleaved 1 (human), hCTSG/Clv:1

organism-modification


PR:000076992 cathepsin G deaminated 1 (human), hCTSG/Deam:1

organism-gene


PR:P17977 cathepsin G (rat), rCTSG

organism-gene


PR:P28293 cathepsin G (mouse), mCTSG

modification


PR:000019567 cathepsin G, signal peptide removed form, CTSG/SigPep-

modification


PR:000035924 cathepsin G cleaved 1, CTSG/Clv:1

organism-modification


PR:000035925 cathepsin G cleaved 1 (human), hCTSG/Clv:1

modification


PR:000019568 cathepsin G proteolytic cleavage product, CTSG/ClvPrd

gene


PR:000006029 cathepsin H, CTSH

organism-gene


PR:P00786 pro-cathepsin H (rat), rCTSH

organism-sequence


PR:P00786-1 pro-cathepsin H isoform 1 (rat), rCTSH/iso:1

organism-gene


PR:P09668 pro-cathepsin H (human), hCTSH

organism-modification


PR:000066541 pro-cathepsin H glutathionylated 1 (human), hCTSH/SGlt:1

organism-modification


PR:000067353 pro-cathepsin H glutathionylated 2 (human), hCTSH/SGlt:2

organism-modification


PR:000068758 pro-cathepsin H glutathionylated 3 (human), hCTSH/SGlt:3

organism-modification


PR:000073015 pro-cathepsin H deaminated 1 (human), hCTSH/Deam:1

organism-gene


PR:P49935 pro-cathepsin H (mouse), mCTSH

organism-sequence


PR:P49935-1 pro-cathepsin H isoform 1 (mouse), mCTSH/iso:1

organism-gene


PR:Q8H166 thiol protease aleurain (Arabidopsis thaliana), At-CTSH

organism-sequence


PR:Q8H166-1 thiol protease aleurain isoform 1 (Arabidopsis thaliana), At-CTSH/iso:1

sequence


PR:000039616 cathepsin H isoform 1, CTSH/iso:1

organism-sequence


PR:P00786-1 pro-cathepsin H isoform 1 (rat), rCTSH/iso:1

organism-sequence


PR:P49935-1 pro-cathepsin H isoform 1 (mouse), mCTSH/iso:1

modification


PR:000019570 cathepsin H, signal peptide removed form, CTSH/SigPep-

modification


PR:000019571 cathepsin H proteolytic cleavage product, CTSH/ClvPrd

gene


PR:000006030 procathepsin L, CTSL

organism-gene


PR:P07711 procathepsin L (human), hCTSL

organism-sequence


PR:P07711-1 procathepsin L isoform h1 (human), hCTSL/iso:h1

organism-sequence


PR:P07711-3 procathepsin L isoform h2 (human), hCTSL/iso:h2

organism-modification


PR:000053979 procathepsin L N-glycosylated 1 (human), hCTSL/NGlyco:1

organism-modification


PR:000071161 procathepsin L cysteinylated 1 (human), hCTSL/Cyst:1

modification


PR:000019573 procathepsin L, signal peptide removed form, CTSL/SigPep-

modification


PR:000019574 procathepsin L proteolytic cleavage product, CTSL/ClvPrd

gene


PR:000006031 cathepsin L2, CTSV

organism-gene


PR:O60911 cathepsin L2 (human), hCTSV

organism-modification


PR:000066151 cathepsin L2 cysteinylated 1 (human), hCTSV/Cyst:1

organism-gene


PR:P25975 procathepsin L (cow), cow-CTSV

modification


PR:000019575 cathepsin L2 proteolytic cleavage product, CTSL2/ClvPrd

gene


PR:000006032 cathepsin O, CTSO

organism-gene


PR:P43234 cathepsin O (human), hCTSO

organism-gene


PR:Q8BM88 cathepsin O (mouse), mCTSO

modification


PR:000019576 cathepsin O proteolytic cleavage product, CTSO/ClvPrd

gene


PR:000006033 cathepsin S, CTSS

organism-gene


PR:O70370 cathepsin S (mouse), mCTSS

organism-gene


PR:P25774 cathepsin S (human), hCTSS

organism-sequence


PR:P25774-1 cathepsin S isoform h1 (human), hCTSS/iso:h1

organism-sequence


PR:P25774-2 cathepsin S isoform h2 (human), hCTSS/iso:h2

organism-modification


PR:000065220 cathepsin S methylated 1 (human), hCTSS/Me:1

organism-modification


PR:000066825 cathepsin S deaminated 1 (human), hCTSS/Deam:1

organism-modification


PR:000067604 cathepsin S glutathionylated 1 (human), hCTSS/SGlt:1

organism-modification


PR:000073880 cathepsin S deaminated 2 (human), hCTSS/Deam:2

organism-modification


PR:000077000 cathepsin S cysteinylated 1 (human), hCTSS/Cyst:1

organism-gene


PR:P54640 cysteine proteinase 5 (Dictyostelium discoideum), Dicty-CTSS

organism-gene


PR:Q02765 cathepsin S (rat), rCTSS

organism-gene


PR:Q9SUS9 probable cysteine protease RDL5 (Arabidopsis thaliana), At-CTSS

modification


PR:000019577 cathepsin S proteolytic cleavage product, CTSS/ClvPrd

gene


PR:000006034 cathepsin W, CTSW

organism-gene


PR:P56202 cathepsin W (human), hCTSW

organism-gene


PR:P56203 cathepsin W (mouse), mCTSW

modification


PR:000019579 cathepsin W, signal peptide removed form, CTSW/SigPep-

gene


PR:000006035 cathepsin Z, CTSZ

organism-gene


PR:G5EGP8 cathepsin Z-1 (worm), CTSZ (worm)

organism-sequence


PR:G5EGP8-1 cathepsin Z-1 isoform a (worm), CTSZ/iso:a (worm)

organism-sequence


PR:G5EGP8-2 cathepsin Z-1 isoform b (worm), CTSZ/iso:b (worm)

organism-gene


PR:Q9R1T3 cathepsin Z (rat), rCTSZ

organism-sequence


PR:Q9R1T3-1 cathepsin Z isoform 1 (rat), rCTSZ/iso:1

organism-gene


PR:Q9UBR2 cathepsin Z (human), hCTSZ

organism-modification


PR:000067002 cathepsin Z deaminated 1 (human), hCTSZ/Deam:1

organism-modification


PR:000069819 cathepsin Z deaminated 2 (human), hCTSZ/Deam:2

organism-modification


PR:000072679 cathepsin Z methylated 1 (human), hCTSZ/Me:1

organism-modification


PR:000078896 cathepsin Z deaminated 3 (human), hCTSZ/Deam:3

organism-gene


PR:Q9WUU7 cathepsin Z (mouse), mCTSZ

organism-sequence


PR:Q9WUU7-1 cathepsin Z isoform 1 (mouse), mCTSZ/iso:1

organism-modification


PR:000070238 cathepsin Z cysteinylated 1 (mouse), mCTSZ/Cyst:1

sequence


PR:000044078 cathepsin Z isoform 1, CTSZ/iso:1

organism-sequence


PR:Q9R1T3-1 cathepsin Z isoform 1 (rat), rCTSZ/iso:1

organism-sequence


PR:Q9WUU7-1 cathepsin Z isoform 1 (mouse), mCTSZ/iso:1

modification


PR:000019580 cathepsin Z proteolytic cleavage product, CTSZ/ClvPrd

gene


PR:000006213 cathepsin J, Ctsj

organism-gene


PR:Q63088 cathepsin J (rat), rCtsj

organism-gene


PR:Q9R014 cathepsin J (mouse), mCtsj

modification


PR:000019639 cathepsin J proteolytic cleavage product, Ctsj/ClvPrd

gene


PR:000006214 cathepsin M, Ctsm

organism-gene


PR:Q9JL96 cathepsin M (mouse), mCtsm

modification


PR:000019640 cathepsin M proteolytic cleavage product, Ctsm/ClvPrd

gene


PR:000006215 cathepsin R, Ctsr

organism-gene


PR:Q9JIA9 cathepsin R (mouse), mCtsr

gene


PR:000033780 cathepsin 7, Cts7

organism-gene


PR:D3ZZ07 cathepsin 7 (rat), rCts7

organism-sequence


PR:D3ZZ07-1 cathepsin 7 isoform 1 (rat), rCts7/iso:1

organism-gene


PR:Q91ZF2 cathepsin 7 (mouse), mCts7

organism-sequence


PR:Q91ZF2-1 cathepsin 7 isoform 1 (mouse), mCts7/iso:1

sequence


PR:000042274 cathepsin 7 isoform 1, Cts7/iso:1

organism-sequence


PR:D3ZZ07-1 cathepsin 7 isoform 1 (rat), rCts7/iso:1

organism-sequence


PR:Q91ZF2-1 cathepsin 7 isoform 1 (mouse), mCts7/iso:1

gene


PR:000040360 murine-type cathepsin L, murine-Ctsl

organism-gene


PR:P06797 procathepsin L (mouse), mCtsl

organism-seqgroup


PR:000037136 cathepsin L short form (mouse), mCtsl/iso:[2/3/4/5/6/7]
Yes
organism-sequence


PR:000037114 procathepsin L isoform 2 (mouse), mCtsl/iso:2

organism-sequence


PR:000037116 procathepsin L isoform 3 (mouse), mCtsl/iso:3

organism-sequence


PR:000037118 procathepsin L isoform 4 (mouse), mCtsl/iso:4

organism-sequence


PR:000037120 procathepsin L isoform 5 (mouse), mCtsl/iso:5

organism-sequence


PR:000037122 procathepsin L isoform 6 (mouse), mCtsl/iso:6

organism-sequence


PR:000037124 procathepsin L isoform 7 (mouse), mCtsl/iso:7

organism-sequence


PR:000037114 procathepsin L isoform 2 (mouse), mCtsl/iso:2

organism-sequence


PR:000037116 procathepsin L isoform 3 (mouse), mCtsl/iso:3

organism-sequence


PR:000037118 procathepsin L isoform 4 (mouse), mCtsl/iso:4

organism-sequence


PR:000037120 procathepsin L isoform 5 (mouse), mCtsl/iso:5

organism-sequence


PR:000037122 procathepsin L isoform 6 (mouse), mCtsl/iso:6

organism-sequence


PR:000037124 procathepsin L isoform 7 (mouse), mCtsl/iso:7

organism-sequence


PR:P06797-1 procathepsin L isoform 1 (mouse), mCtsl/iso:1
Yes
organism-modification


PR:000037126 procathepsin L isoform 1, signal peptide removed form (mouse), mCtsl/iso:1/SigPep-

organism-gene


PR:P07154 procathepsin L (rat), rCtsl

sequence


PR:000037111 murine-type cathepsin L isoform 1, murine-Ctsl/iso:1

organism-sequence


PR:P06797-1 procathepsin L isoform 1 (mouse), mCtsl/iso:1
Yes
organism-modification


PR:000037126 procathepsin L isoform 1, signal peptide removed form (mouse), mCtsl/iso:1/SigPep-

modification


PR:000037125 murine-type cathepsin L isoform 1, signal peptide removed form, murine-Ctsl/iso:1/SigPep-

organism-modification


PR:000037126 procathepsin L isoform 1, signal peptide removed form (mouse), mCtsl/iso:1/SigPep-

sequence


PR:000037113 murine-type cathepsin L isoform 2, murine-Ctsl/iso:2

organism-sequence


PR:000037114 procathepsin L isoform 2 (mouse), mCtsl/iso:2

sequence


PR:000037115 murine-type cathepsin L isoform 3, murine-Ctsl/iso:3

organism-sequence


PR:000037116 procathepsin L isoform 3 (mouse), mCtsl/iso:3

sequence


PR:000037117 murine-type cathepsin L isoform 4, murine-Ctsl/iso:4

organism-sequence


PR:000037118 procathepsin L isoform 4 (mouse), mCtsl/iso:4

sequence


PR:000037119 murine-type cathepsin L isoform 5, murine-Ctsl/iso:5

organism-sequence


PR:000037120 procathepsin L isoform 5 (mouse), mCtsl/iso:5

sequence


PR:000037121 murine-type cathepsin L isoform 6, murine-Ctsl/iso:6

organism-sequence


PR:000037122 procathepsin L isoform 6 (mouse), mCtsl/iso:6

sequence


PR:000037123 murine-type cathepsin L isoform 7, murine-Ctsl/iso:7

organism-sequence


PR:000037124 procathepsin L isoform 7 (mouse), mCtsl/iso:7

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037136 mCtsl/iso:[2/3/4/5/6/7]
Short-form CatL | cytosolic CatL
"A procathepsin L (mouse) that is translated using an internal start codon relative to isoform 1 (PR:P06797-1) and which thus lacks the signal peptide encoding region." [PRO:KRC]		 acts_upstream_of_or_withinGO:0016485 protein processing MGI:3044037; PMID:15099520
GO:0016485 protein processing MGI:3044037; PMID:15099520
GO:0032956 regulation of actin cytoskeleton organization MGI:5297732; PMID:21911934
located_inGO:0005634 nucleus MGI:5297732; PMID:21911934
GO:0005634 nucleus MGI:5297732; PMID:21911934
PR:P06797-1 mCtsl/iso:1
cathepsin L1 pre-pro form (mouse) | cathepsin L1 precursor (mouse)
"A murine-type cathepsin L isoform 1 that is encoded in the genome of mouse." [PMID:3689328, PRO:KRC]		 acts_upstream_of_or_withinGO:0016540 protein autoprocessing MGI:5513110; PMID:1482371