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Protein Ontology report - dopamine receptor
PR:000044633 - http://purl.obolibrary.org/obo/PR_000044633
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000044633   
  PRO namedopamine receptor 
  Definition"A rhodopsin-like G-protein coupled receptor that is a translation product of the human DRD1 to DRD5 genes, 1:1 orthologs thereof, or pro-orthologs thereof." [PRO:XQ] 
  CommentPro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology). 
  PRO Categoryfamily 
  ParentPR:000001094 rhodopsin-like G-protein coupled receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family3                                                  Organism-Family 0                                        
         Gene5                                                  Organism-Gene 21                                        
         Sequence4                                                  Organism-Sequence 29                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARfam:20
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000044633 dopamine receptor, hPSEN1/var:F205L

family


PR:000001107 D(1)-like dopamine receptor, ALCAM

gene


PR:000001175 D(1A) dopamine receptor, DRD1

organism-gene


PR:P18901 D(1A) dopamine receptor (rat), rDRD1

organism-gene


PR:P21728 D(1A) dopamine receptor (human), hDRD1

organism-modification


PR:000045711 D(1A) dopamine receptor phosphorylated 1 (human), hDRD1/Phos:1

organism-gene


PR:P50130 D(1A) dopamine receptor (pig), pig-DRD1

organism-gene


PR:Q61616 D(1A) dopamine receptor (mouse), mDRD1

organism-gene


PR:Q95136 D(1A) dopamine receptor (cow), cow-DRD1

gene


PR:000001176 D(1B) dopamine receptor, DRD5

organism-gene


PR:P21918 D(1B) dopamine receptor (human), hDRD5

organism-gene


PR:P25115 D(1B) dopamine receptor (rat), rDRD5

organism-gene


PR:P41596 dopamine receptor 1 (fruit fly), fly-DRD5

organism-sequence


PR:P41596-1 dopamine receptor 1 isoform A (fruit fly), fly-DRD5/iso:A

organism-sequence


PR:P41596-2 dopamine receptor 1 isoform B (fruit fly), fly-DRD5/iso:B

organism-sequence


PR:P41596-3 dopamine receptor 1 isoform C (fruit fly), fly-DRD5/iso:C

organism-gene


PR:Q8BLD9 D(1B) dopamine receptor (mouse), mDRD5

family


PR:000001108 D(2)-like dopamine receptor, ALCAM

gene


PR:000001177 D(2) dopamine receptor, DRD2

organism-gene


PR:P14416 D(2) dopamine receptor (human), hDRD2

organism-sequence


PR:P14416-1 D(2) dopamine receptor isoform 1 (human), hDRD2/iso:1

organism-sequence


PR:P14416-2 D(2) dopamine receptor isoform 2 (human), hDRD2/iso:2

organism-sequence


PR:P14416-3 D(2) dopamine receptor isoform h3 (human), hDRD2/iso:h3

organism-gene


PR:P61168 D(2) dopamine receptor (mouse), mDRD2

organism-sequence


PR:P61168-1 D(2) dopamine receptor isoform 1 (mouse), mDRD2/iso:1
Yes
organism-sequence


PR:P61168-2 D(2) dopamine receptor isoform 2 (mouse), mDRD2/iso:2
Yes
organism-gene


PR:P61169 D(2) dopamine receptor (rat), rDRD2

organism-sequence


PR:P61169-1 D(2) dopamine receptor isoform Long (rat), rDRD2/iso:Long

organism-sequence


PR:P61169-2 D(2) dopamine receptor isoform Short (rat), rDRD2/iso:Short

organism-gene


PR:Q6RYS9 dopamine receptor 3 (worm), DRD2 (worm)

organism-sequence


PR:Q6RYS9-1 dopamine receptor 3 isoform b (worm), DRD2/iso:b (worm)

organism-sequence


PR:Q6RYS9-2 dopamine receptor 3 isoform a (worm), DRD2/iso:a (worm)

organism-sequence


PR:Q6RYS9-3 dopamine receptor 3 isoform c (worm), DRD2/iso:c (worm)

organism-sequence


PR:Q6RYS9-4 dopamine receptor 3 isoform d (worm), DRD2/iso:d (worm)

organism-gene


PR:Q8IS44 dopamine D2-like receptor (fruit fly), fly-DRD2

organism-sequence


PR:Q8IS44-1 dopamine D2-like receptor isoform H (fruit fly), fly-DRD2/iso:H

organism-sequence


PR:Q8IS44-2 dopamine D2-like receptor isoform J (fruit fly), fly-DRD2/iso:J

organism-sequence


PR:Q8IS44-3 dopamine D2-like receptor isoform F (fruit fly), fly-DRD2/iso:F

organism-sequence


PR:Q8IS44-4 dopamine D2-like receptor isoform B (fruit fly), fly-DRD2/iso:B

organism-sequence


PR:Q8IS44-5 dopamine D2-like receptor isoform G (fruit fly), fly-DRD2/iso:G

organism-sequence


PR:Q8IS44-6 dopamine D2-like receptor isoform I (fruit fly), fly-DRD2/iso:I

organism-gene


PR:Q9GJU1 D(2) dopamine receptor (dog), dog-DRD2

sequence


PR:000037412 D(2) dopamine receptor isoform 1, DRD2/iso:1

organism-sequence


PR:P14416-1 D(2) dopamine receptor isoform 1 (human), hDRD2/iso:1

organism-sequence


PR:P61168-1 D(2) dopamine receptor isoform 1 (mouse), mDRD2/iso:1
Yes
sequence


PR:000037413 D(2) dopamine receptor isoform 2, DRD2/iso:2

organism-sequence


PR:P14416-2 D(2) dopamine receptor isoform 2 (human), hDRD2/iso:2

organism-sequence


PR:P61168-2 D(2) dopamine receptor isoform 2 (mouse), mDRD2/iso:2
Yes
gene


PR:000001178 D(3) dopamine receptor, DRD3

organism-gene


PR:P19020 D(3) dopamine receptor (rat), rDRD3

organism-sequence


PR:P19020-1 D(3) dopamine receptor isoform 1 (rat), rDRD3/iso:1

organism-sequence


PR:P19020-2 D(3) dopamine receptor isoform rD3(TM3-del) (rat), rDRD3/iso:rD3(TM3-del)

organism-sequence


PR:P19020-3 D(3) dopamine receptor isoform rD3(O2-DEL) (rat), rDRD3/iso:rD3(O2-DEL)

organism-gene


PR:P30728 D(3) dopamine receptor (mouse), mDRD3

organism-sequence


PR:P30728-1 D(3) dopamine receptor isoform D3Long (mouse), mDRD3/iso:D3Long

organism-sequence


PR:P30728-2 D(3) dopamine receptor isoform D3Short (mouse), mDRD3/iso:D3Short
Yes
organism-gene


PR:P35462 D(3) dopamine receptor (human), hDRD3

organism-sequence


PR:P35462-1 D(3) dopamine receptor isoform 1 (human), hDRD3/iso:1

organism-sequence


PR:P35462-3 D(3) dopamine receptor isoform h3 (human), hDRD3/iso:h3

organism-modification


PR:000069676 D(3) dopamine receptor phosphorylated 1 (human), hDRD3/Phos:1

sequence


PR:000039260 D(3) dopamine receptor isoform 1, DRD3/iso:1

organism-sequence


PR:P19020-1 D(3) dopamine receptor isoform 1 (rat), rDRD3/iso:1

organism-sequence


PR:P30728-1 D(3) dopamine receptor isoform D3Long (mouse), mDRD3/iso:D3Long

gene


PR:000001179 D(4) dopamine receptor, DRD4

organism-gene


PR:P21917 D(4) dopamine receptor (human), hDRD4

organism-gene


PR:P30729 D(4) dopamine receptor (rat), rDRD4

organism-sequence


PR:P30729-1 D(4) dopamine receptor isoform 1 (rat), rDRD4/iso:1

organism-gene


PR:P51436 D(4) dopamine receptor (mouse), mDRD4

organism-sequence


PR:P51436-1 D(4) dopamine receptor isoform 1 (mouse), mDRD4/iso:1

sequence


PR:000039659 D(4) dopamine receptor isoform 1, DRD4/iso:1

organism-sequence


PR:P30729-1 D(4) dopamine receptor isoform 1 (rat), rDRD4/iso:1

organism-sequence


PR:P51436-1 D(4) dopamine receptor isoform 1 (mouse), mDRD4/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P30728-2 mDRD3/iso:D3Short

"A D(3) dopamine receptor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30728-2." [PRO:DNx, UniProtKB:P30728]		 enablesGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:71957; PMID:8449953
PR:P61168-1 mDRD2/iso:1
D2A (mouse)
"A D(2) dopamine receptor isoform 1 that is encoded in the genome of mouse." [PMID:1991517, PRO:KRC]		 acts_upstream_of_or_withinGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway MGI:893272; PMID:7706278
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway MGI:893272; PMID:7706278
GO:0007212 dopamine receptor signaling pathway MGI:2181304; PMID:11089973
GO:0007626 locomotory behavior MGI:1927281; PMID:11069937
GO:0032228 regulation of synaptic transmission, GABAergic MGI:3628700; PMID:15489038
GO:0060134 prepulse inhibition MGI:3611062; PMID:12476322
enablesGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:893272; PMID:7706278
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:893272; PMID:7706278
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:893272; PMID:7706278
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:893272; PMID:7706278
located_inGO:0016020 membrane MGI:893272; PMID:7706278
PR:P61168-2 mDRD2/iso:2
D2B (mouse)
"A D(2) dopamine receptor isoform 2 that is encoded in the genome of mouse." [PMID:11069937, PMID:1991517, PRO:KRC]		 acts_upstream_of_or_withinGO:0001975 response to amphetamine MGI:3611062; PMID:12476322
GO:0014059 regulation of dopamine secretion MGI:3655899; PMID:11943831
GO:0032228 regulation of synaptic transmission, GABAergic MGI:3628700; PMID:15489038
GO:0042220 response to cocaine MGI:3655899; PMID:11943831
GO:0043278 response to morphine MGI:3655899; PMID:11943831
GO:0051967 negative regulation of synaptic transmission, glutamatergic MGI:3628700; PMID:15489038
GO:0060160 negative regulation of dopamine receptor signaling pathway MGI:2181304; PMID:11089973
enablesGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:892768; PMID:1991517
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:892768; PMID:1991517