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Protein Ontology report - serine/threonine-protein kinase PLK1 phosphorylated 1 (human)
PR:000044818 -
http://purl.obolibrary.org/obo/PR_000044818
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:000044818
PRO name
serine/threonine-protein kinase PLK1 phosphorylated 1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hPLK1/Phos:1
PRO-proteoform-std
:
EXACT:
UniProtKB:P53350
, Ser-99,
MOD:00046
|Thr-210,
MOD:00047
Definition
"A serine/threonine-protein kinase PLK1 (human) that has been phosphorylated on a Ser residue that is within a 14-3-3 recognition motif, and a Thr residue that is in the activation loop and is an Aurora kinase phosphorylation site.
UniProtKB:P53350
, Ser-99,
MOD:00046
|Thr-210,
MOD:00047
." [
PMID:23695676
, PRO:CNA]
Comment
Evidence=(ECO:0000006,
PMID:23695676
). Kinase=("AKT";
PR:000029189
; Ser-99). Kinase=("AURKA";
PR:O14965
; Thr-210). Note: Proteoform created based on papers selected via the eFIP text mining tool.
PRO Category
organism-modification
Parent
PR:000037070
PR:P53350
Taxon
NCBITaxon:9606
Homo sapiens
Term Hierarchy
Visualization
DAG:
OLS:
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Functional Annotation (PRO-centric view)
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PRO Term
GO Annotation
Evidence
PR:000044818
hPLK1/Phos:1
UniProtKB:P53350, Ser-99, MOD:00046|Thr-210, MOD:00047
acts_upstream_of_or_within
GO:0007091
metaphase/anaphase transition of mitotic cell cycle
PMID:23695676
enables
GO:0071889
14-3-3 protein binding
with
PR:P61981
hYWHAG
PMID:23695676