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Protein Ontology report - pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 1 (human)
PR:000044826 -
http://purl.obolibrary.org/obo/PR_000044826
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:000044826
PRO name
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hPDHA1/TransPep-/Phos:1
PRO-proteoform-std
:
EXACT:
UniProtKB:P08559
, 31-390, Ser-232,
MOD:00046
NARROW:
UniProtKB:P08559-1
, 31-390, Ser-232,
MOD:00046
Other
:
NARROW:
PRO_0000020440, Ser-232,
MOD:00046
Definition
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-232 of the amino acid sequence represented by
UniProtKB:P08559-1
. Example:
UniProtKB:P08559-1
, 31-390, Ser-232,
MOD:00046
." [
PMID:11485553
,
PMID:19341700
,
PMID:7782287
, PRO:AEL]
Comment
Kinase=("PDK1";
PR:Q15118
; Ser-232). Evidence=(ECO:0000181, for phosphorylation). Evidence=(ECO:0000178, for phosphorylation). Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on
PMID:23146587
).
PRO Category
organism-modification
Parent
PR:000037070
phosphoprotein
PR:000044835
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
Taxon
NCBITaxon:9606
Homo sapiens
Term Hierarchy
Visualization
DAG:
OLS:
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Functional Annotation (PRO-centric view)
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PRO Term
GO Annotation
Evidence
PR:000044826
hPDHA1/TransPep-/Phos:1
UniProtKB:P08559, 31-390, Ser-232, MOD:00046 | UniProtKB:P08559-1, 31-390, Ser-232, MOD:00046 | PRO_0000020440, Ser-232, MOD:00046
"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-232 of the amino acid sequence represented by UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-232, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
enables
NOT
GO:0004738
pyruvate dehydrogenase activity
PMID:11092882
;
PMID:7782287