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Protein Ontology report - pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 3 (human)

PR:000044828 - http://purl.obolibrary.org/obo/PR_000044828

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Ontology Information

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PAF

GPI

PRO ID

PR:000044828

PRO name

pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 3 (human)

Synonyms

PRO-Short-label:	EXACT:	hPDHA1/TransPep-/Phos:3
PRO-proteoform-std:	EXACT:	UniProtKB:P08559, 31-390, Ser-300, MOD:00046
	NARROW:	UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046
Other:	NARROW:	PRO_0000020440, Ser-300, MOD:00046

Definition

"A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-300 of the amino acid sequence UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]

Comment

Kinase=("PDK1"; PR:Q15118; Ser-300). Kinase=("PDK2"; PR:Q15119; Ser-300). Kinase=("PDK3"; PR:Q15120; Ser-300). Kinase=("PDK4"; PR:Q16654; Ser-300). Evidence=(ECO:0000181, for phosphorylation). Evidence=(ECO:0000178, for phosphorylation). Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on PMID:23146587).

PRO Category

organism-modification

Parent

PR:000037070
PR:000044835

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy
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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000044828 hPDHA1/TransPep-/Phos:3 UniProtKB:P08559, 31-390, Ser-300, MOD:00046 \| UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046 \| PRO_0000020440, Ser-300, MOD:00046	enables	NOT GO:0004738 pyruvate dehydrogenase activity	PMID:11092882; PMID:7782287