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RACE-PRO
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Protein Ontology report - interferon regulatory factor 3 isoform 1 phosphorylated 2 (human)
PR:000045489 -
http://purl.obolibrary.org/obo/PR_000045489
Complex
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000045489
PRO name
interferon regulatory factor 3 isoform 1 phosphorylated 2 (human)
Synonyms
PRO-Short-label
:
EXACT:
hIRF3/iso:1/Phos:2
PRO-proteoform-std
:
EXACT:
UniProtKB:Q14653-1
, Ser-339/Ser-386/Ser-398/Ser-402/Ser-405,
MOD:00046
|Thr-404,
MOD:00047
Other
:
RELATED:
p-5S,T404-IRF3 (human)
Definition
"An interferon regulatory factor 3 isoform 1 (human) that has been phosphorylated in Ser-339 and Ser and Thr residues within the two phosphorylation cluster sites. A Ser-386 on the 2S site and multiple Ser and Thr residues in the 5ST site (Ser-396, Ser-498, Ser-402, Thr-404, and Ser-405).
UniProtKB:Q14653-1
, Ser-339/Ser-386/Ser-398/Ser-402/Ser-405,
MOD:00046
|Thr-404,
MOD:00047
." [PRO:CNA,
Reactome:R
-HSA-936418]
Comment
Note: Reactome does not specify the precise isoform. However, it mentions that this proteoform is involved in dimerization. Based on the positions of the modified residues, and based on the position of the dimerization domain (203-385), only isoform 1 is eligible. [PRO:DAN,
PMID:23824805
].
PRO Category
organism-modification
Parent
PR:000003259
PR:Q14653
Taxon
NCBITaxon:9606
Homo sapiens
Term Hierarchy
Visualization
DAG:
OLS:
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hIRF3/iso:1/Phos:2
forms found in complexes
hIRF3/iso:1/Phos:2
Component
Complexes
PR:000045489
hIRF3/iso:1/Phos:2
PR:000027084