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Protein Ontology report - epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human)

PR:000049849 - http://purl.obolibrary.org/obo/PR_000049849

Annotations

Ontology Information

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PAF

GPI

PRO ID

PR:000049849

PRO name

epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human)

Synonyms

PRO-Short-label:	EXACT:	hEGFR/SigPep-/Phos:3
PRO-proteoform-std:	EXACT:	UniProtKB:P00533, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046
	NARROW:	UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046

Definition

"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046." [PMID:10347170, PRO:KER]

Comment

Evidence=(ECO:0000006, based on PMID:10347170). Kinase=("CAMKII"; PR:000003197; Ser-1070/Ser-1071/Ser-1081/Ser-1166). Note: Ser-1166 is the major site of phosphorylation; this phosphorylation is involved in down-regulation of kinase activity.

PRO Category

organism-modification

Parent

PR:000028422 epidermal growth factor receptor, signal peptide removed form (human)
PR:000037070 phosphoprotein

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy
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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000049849 hEGFR/SigPep-/Phos:3 UniProtKB:P00533, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046 \| UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046 "An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046." [PMID:10347170, PRO:KER]	enables	decreased GO:0004713 protein tyrosine kinase activity relative to PR:000049850 hEGFR/SigPep-/UnPhos:3	PMID:10347170
		decreased GO:0005515 protein binding relative to PR:000049850 hEGFR/SigPep-/UnPhos:3	PMID:10347170