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Protein Ontology report - protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human) PR:000049855 - http://purl.obolibrary.org/obo/PR_000049855        Annotations       Ontology Information Show OBO stanza / PAF / GPI   PRO ID PR:000049855      PRO name protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)    Synonyms PRO-Short-label: EXACT: hPRKCB/iso:Beta-II/InitMet-/Phos:2 PRO-proteoform-std: EXACT: UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046   Definition "A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]    Comment Evidence=(ECO:0000006, based on PMID:8749392). Kinase=("PRKCB"; PR:P05771; Thr-641/Ser-660).    PRO Category organism-modification    Parent PR:000037070 phosphoprotein PR:000048913 protein kinase C beta type, initiator methionine removed form (human) PR:P05771 protein kinase C beta type (human)   Taxon NCBITaxon:9606 Homo sapiens   Term Hierarchy   Visualization DAG: OLS: Back to top Functional Annotation (PRO-centric view) Switch to GO Centric View    PRO Term GO Annotation Evidence PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2 UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046 "A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER] acts_upstream_of_or_within increased GO:0006468 protein phosphorylation relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:8749392 enables increased GO:0001786 phosphatidylserine binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480 increased GO:0005509 calcium ion binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480 located_in increased GO:0005737 cytoplasm relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9756933