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PRO ID
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| PRO name | IgG4 immunoglobulin complex (human) |
| Synonyms | | PRO-Short-label: | EXACT: | hIgG4 | | Other: | EXACT: | IgG4 (human) | | NARROW: | IgG4 antibody (human) | | | |
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| Definition | "An IgG immunoglobulin complex in human that is composed of two immunoglobulin heavy chains of an IgG4 isotype and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG4 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations." [GOC:add, PMID:19222496, PMID:25368619, PRO:ADD] |
| Comment | Requested by=HIPC. Requested by=CL. Note: An IgG4 immunoglobulin complex has the function of antigen binding if a suitable antigen is available. |
| PRO Category | organism-complex |
| Parent | G0071735
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| Taxon | NCBITaxon:9606 Homo sapiens |
| Terms by PRO Category |
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms | | Complex | 0 |
Organism-Complex |
3 | | | |
Term Hierarchy
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