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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)
PR:O60566 - http://purl.obolibrary.org/obo/PR_O60566
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:O60566   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) 
  Synonyms
PRO-Short-label: EXACT:hBUB1B
Gene-based: RELATED:BUB1B | BUBR1 | MAD3L | SSK1
Other: EXACT:hBUBR1 | MAD3/BUB1-related protein kinase (human) | mitotic checkpoint kinase MAD3L (human) | protein SSK1 (human)
  Definition"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60566] 
  PRO Categoryorganism-gene 
  ParentPR:000004855
PR:000029067
  Gene TemplateHGNC:1149 BUB1B (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 16                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O60566
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human), hBUB1B
Yes
Yes
organism-sequence


PR:O60566-1 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human), hBUB1B/iso:1

organism-modification


PR:000028798 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human), hBUB1B/iso:1/Ac:1

organism-sequence


PR:O60566-2 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h2 (human), hBUB1B/iso:h2

organism-sequence


PR:O60566-3 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h3 (human), hBUB1B/iso:h3

organism-modification


PR:000035362 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human), hBUB1B/Phos:1
Yes
organism-modification


PR:000035373 mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human), hBUB1B/PhosRes-
Yes
Yes
organism-modification


PR:000035428 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human), hBUB1B/Phos:2
Yes
Yes
organism-modification


PR:000035432 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human), hBUB1B/Phos:3
Yes
organism-modification


PR:000035435 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human), hBUB1B/Phos:4
Yes
organism-modification


PR:000065892 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 1 (human), hBUB1B/Me:1

organism-modification


PR:000066223 mitotic checkpoint serine/threonine-protein kinase BUB1 beta cysteinylated 1 (human), hBUB1B/Cyst:1

organism-modification


PR:000070779 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 1 (human), hBUB1B/Deam:1

organism-modification


PR:000074218 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 2 (human), hBUB1B/Deam:2

organism-modification


PR:000074309 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 2 (human), hBUB1B/Me:2

organism-modification


PR:000076756 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 3 (human), hBUB1B/Me:3

organism-modification


PR:000077474 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 4 (human), hBUB1B/Me:4

organism-modification


PR:000077494 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 3 (human), hBUB1B/Deam:3

organism-modification


PR:000078944 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 5 (human), hBUB1B/Me:5

organism-modification


PR:000080893 mitotic checkpoint serine/threonine-protein kinase BUB1 beta citrullinated 1 (human), hBUB1B/Cit:1

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hBUB1B forms found in complexes   

hBUB1B Component
 Complexes
PR:000035373 hBUB1B/PhosRes- PR:000035579
PR:000035428 hBUB1B/Phos:2 PR:000035577
PR:O60566 hBUB1B PR:000035511^P000035563^P000035575
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035362
hBUB1B/Phos:1
UniProtKB:O60566, Thr-620, MOD:00047 | UniProtKB:O60566-1, Thr-620, MOD:00047 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated		 enablesincreased GO:0005515 protein binding with PR:P53350 hPLK1 PMID:17785528
PR:000035373
hBUB1B/PhosRes-
 acts_upstream_of_or_withinGO:0001933 negative regulation of protein phosphorylation PMID:22801780
GO:0010826 negative regulation of centrosome duplication PMID:19503101
GO:0033673 negative regulation of kinase activity PMID:19503101
enablesGO:0005515 protein binding with PR:000035669 hPLK1/PhosRes- PMID:19503101
located_inGO:0000776 kinetochore PMID:22801780
GO:0005813 centrosome PMID:19503101
PR:000035428
hBUB1B/Phos:2
UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047) | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated		 acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:18440313
increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528
increased GO:0051310 metaphase chromosome alignment relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779; PMID:17785528
enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779
increased GO:0005515 protein binding with PR:O43683 BUB1 PMID:23079597
increased GO:0005515 protein binding with PR:Q15172 hPPP2R5A PMID:23079597
increased GO:0005515 protein binding relative to PR:000035425 frog-BUB1B/PhosRes- PMID:23079597
located_inGO:0000776 kinetochore PMID:17785528
PR:000035432
hBUB1B/Phos:3
UniProtKB:O60566, Thr-608, MOD:00047 | UniProtKB:O60566-1, Thr-608, MOD:00047 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated		 acts_upstream_of_or_withindecreased GO:0001933 negative regulation of protein phosphorylation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0007059 chromosome segregation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0031577 spindle checkpoint signaling relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
located_inGO:0000776 kinetochore PMID:22801780
PR:000035435
hBUB1B/Phos:4
UniProtKB:O60566, Ser-543/Ser-670/Ser-1043, MOD:00046 | UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated		 acts_upstream_of_or_withinincreased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317; PMID:20016069
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069
located_inGO:0000776 kinetochore PMID:19015317
PR:O60566
hBUB1B
BUB1B | BUBR1 | MAD3L | SSK1 | hBUBR1 | MAD3/BUB1-related protein kinase (human) | mitotic checkpoint kinase MAD3L (human) | protein SSK1 (human)		 acts_upstream_of_or_withinGO:0006469 negative regulation of protein kinase activity PMID:15592459
GO:0031577 spindle checkpoint signaling PMID:11030144
GO:0031647 regulation of protein stability PMID:17671183
NOT GO:0034501 protein localization to kinetochore PMID:16760428
GO:0051310 metaphase chromosome alignment PMID:12719470; PMID:15592459
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PMID:15592459
enablesGO:0005515 protein binding with PR:000035449 hCDC27/Phos:1 BioGRID:BG-682429
GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes- BioGRID:BG-682429
GO:0005515 protein binding with PR:O15350 hTP73 BioGRID:BG-682429
GO:0005515 protein binding with PR:O15379 HD3 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:O43683 BUB1 BioGRID:BG-682429
GO:0005515 protein binding with PR:O43684 BUB3 BioGRID:BG-682429
GO:0005515 protein binding with PR:O76070 BCSG1 BioGRID:BG-682429
GO:0005515 protein binding with PR:O95997 EAP1 BioGRID:BG-682429
GO:0005515 protein binding with PR:P04049 cRaf (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:P04637-1 BioGRID:BG-682429
GO:0005515 protein binding with PR:P09874 ADP-ribosyltransferase diphtheria toxin-like 1 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:P25054 APC BioGRID:BG-682429
GO:0005515 protein binding with PR:P51587 BRCA2 BioGRID:BG-682429
GO:0005515 protein binding with PR:P63010 adaptor protein complex AP-2 subunit beta (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q02224 CENP-E (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13042 ANAPC6 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13547 HD1 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q15013 caught by MAD2 protein (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q92769 HD2 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q92831 histone acetylase PCAF (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q96GD4 AIK2 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q96IF1 AJUBA BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9H081 hMIS12 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9H4B4 CNK BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9NQS7 hINCENP BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9UJX3 ANAPC7 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9UJX5 ANAPC4 BioGRID:BG-682429
GO:0016301 kinase activity PMID:11030144
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
located_inGO:0000776 kinetochore PMID:12719470; PMID:16760428
GO:0000922 spindle pole PMID:15190214
GO:0000939 inner kinetochore PMID:11792804
GO:0000940 outer kinetochore PMID:11792804
GO:0005737 cytoplasm PMID:10749118