Protein Ontology

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Protein Ontology report - c-myc protein isoform 1 (human)

PR:P01106-1 - http://purl.obolibrary.org/obo/PR_P01106-1

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Ontology Information

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PRO ID

PR:P01106-1

PRO name

c-myc protein isoform 1 (human)

Synonyms

PRO-Short-label:

EXACT:

hMYC/iso:1

Definition

"A c-myc protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

PRO Category

organism-sequence

Parent

PR:000000228
PR:P01106

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	0	Organism-Sequence	1
Modification	0	Organism-Modification	7

Term Hierarchy
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DAG:

OLS:

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Related Cross References
Db identifiers	UniProtKB:P01106-1

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

organism-sequence

PR:P01106-1 c-myc protein isoform 1 (human), hMYC/iso:1

organism-modification

PR:000026033 c-myc protein isoform 1 acetylated 1 (human), hMYC/iso:1/Ac:1

organism-modification

PR:000026038 c-myc protein isoform 1 unmodified form (human), hMYC/iso:1/UnMod

organism-modification

PR:000026041 c-myc protein isoform 1 phosphorylated 4 (human), hMYC/iso:1/Phos:4

organism-modification

PR:000026051 c-myc protein isoform 1 O-glycosylated 1 (human), hMYC/iso:1/OGlyco:1

organism-modification

PR:000026054 c-myc protein isoform 1 phosphorylated 2 (human), hMYC/iso:1/Phos:2

organism-modification

PR:000026055 c-myc protein isoform 1 phosphorylated 3 (human), hMYC/iso:1/Phos:3

organism-modification

PR:000036448 c-myc protein isoform 1 phosphorylated 1 (human), hMYC/iso:1/Phos:1

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hMYC/iso:1 forms found in complexes

hMYC/iso:1 Component	Complexes
PR:000026033 hMYC/iso:1/Ac:1	PR:000026035
PR:000026038 hMYC/iso:1/UnMod	PR:000026039

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000026033 hMYC/iso:1/Ac:1 UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394	enables	GO:0003700 DNA-binding transcription factor activity	PMID:16126174
	located_in	GO:0005634 nucleus	PMID:16126174
	located_in	GO:0005667 transcription factor complex	PMID:16126174
PR:000026051 hMYC/iso:1/OGlyco:1 UniProtKB:P01106-1, Thr-58, MOD:00806	acts_upstream_of_or_within	GO:0006357 regulation of transcription by RNA polymerase II	PMID:11904304
	enables	GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:11904304
PR:000026054 hMYC/iso:1/Phos:2 UniProtKB:P01106-1, Thr-58, MOD:00047\|Ser-62, MOD:00046	enables	NOT GO:0003700 DNA-binding transcription factor activity	PMID:7623799
PR:000026055 hMYC/iso:1/Phos:3 UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046	acts_upstream_of_or_within	GO:0045766 positive regulation of angiogenesis	PMID:12676581
	located_in	GO:0005634 nucleus	PMID:12676581
PR:000036448 hMYC/iso:1/Phos:1 UniProtKB:P01106-1, Ser-62, MOD:00046	enables	GO:0005515 protein binding with PR:O15169-1	PMID:19131971
PR:P01106-1 hMYC/iso:1	acts_upstream_of_or_within	GO:0006357 regulation of transcription by RNA polymerase II	PMID:16908182; PMID:2006410
		GO:0008283 cell population proliferation	PMID:10962037
		GO:0051726 regulation of cell cycle	PMID:10962037
	enables	contributes_to GO:0003700 DNA-binding transcription factor activity	PMID:16908182; PMID:2006410
	enables	GO:0005515 protein binding	PMID:12706874
	located_in	GO:0005667 transcription factor complex	PMID:16908182; PMID:2006410