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RACE-PRO
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Documentation
Protein Ontology report - protein kinase C beta type (human)
PR:P05771 -
http://purl.obolibrary.org/obo/PR_P05771
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P05771
PRO name
protein kinase C beta type (human)
Synonyms
PRO-Short-label
:
EXACT:
hPRKCB
Gene-based
:
RELATED:
PKCB | PRKCB | PRKCB1
Other
:
EXACT:
PKC-B (human) | PKC-beta (human)
Definition
"A protein kinase C beta type that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P05771
]
PRO Category
organism-gene
Parent
PR:000003059
protein kinase C beta type
PR:000029067
Homo sapiens protein
Gene Template
HGNC:9395
PRKCB (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
2
Modification
0
Organism-Modification
8
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P05771
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:P05771
protein kinase C beta type (human), hPRKCB
organism-sequence
PR:P05771-1
protein kinase C beta type isoform Beta-I (human), hPRKCB/iso:Beta-I
Yes
organism-sequence
PR:P05771-2
protein kinase C beta type isoform Beta-II (human), hPRKCB/iso:Beta-II
Yes
organism-modification
PR:000049853
protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:1
Yes
organism-modification
PR:000049854
protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:1
organism-modification
PR:000049855
protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:2
Yes
organism-modification
PR:000049856
protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
organism-modification
PR:000048913
protein kinase C beta type, initiator methionine removed form (human), hPRKCB/InitMet-
organism-modification
PR:000048914
protein kinase C beta type, initiator methionine removed phosphorylated 1 (human), hPRKCB/InitMet-/Phos:1
organism-modification
PR:000048915
protein kinase C beta type, initiator methionine removed phosphorylated 2 (human), hPRKCB/InitMet-/Phos:2
organism-modification
PR:000049853
protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:1
Yes
organism-modification
PR:000049854
protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:1
organism-modification
PR:000049855
protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:2
Yes
organism-modification
PR:000049856
protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
organism-modification
PR:000049887
protein kinase C beta type phosphorylated 1 (human), hPRKCB/Phos:1
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000049853
hPRKCB/iso:Beta-II/InitMet-/Phos:1
UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047
"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]
enables
increased
GO:0004674
protein serine/threonine kinase activity
relative to
PR:000049854
hPRKCB/iso:Beta-II/InitMet-/UnPhos:1
PMID:8749392
located_in
GO:0005737
cytoplasm
PMID:9756933
GO:0005886
plasma membrane
PMID:9756933
PR:000049855
hPRKCB/iso:Beta-II/InitMet-/Phos:2
UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]
acts_upstream_of_or_within
increased
GO:0006468
protein phosphorylation
relative to
PR:000049856
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
PMID:8749392
enables
increased
GO:0001786
phosphatidylserine binding
relative to
PR:000049856
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
PMID:9218480
increased
GO:0005509
calcium ion binding
relative to
PR:000049856
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
PMID:9218480
located_in
increased
GO:0005737
cytoplasm
relative to
PR:000049856
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
PMID:9756933
PR:P05771-1
hPRKCB/iso:Beta-I
protein kinase C beta type isoform PRKCB1 (human)
"A protein kinase C beta type isoform 1 that is encoded in the genome of human." [PRO:DNx]
acts_upstream_of_or_within
NOT
GO:0001666
response to hypoxia
MGI:3847400
;
PMID:18323529
located_in
GO:0016020
membrane
MGI:3847400
;
PMID:18323529
PR:P05771-2
hPRKCB/iso:Beta-II
protein kinase C beta type isoform PRKCB2 (human)
"A protein kinase C beta type isoform 2 that is encoded in the genome of human." [PRO:DNx]
acts_upstream_of_or_within
GO:0001666
response to hypoxia
MGI:3847400
;
PMID:18323529
located_in
GO:0016020
membrane
MGI:3847400
;
PMID:18323529
