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Protein Ontology report - apoptosis regulator Bcl-2 (human)

PR:P10415 - http://purl.obolibrary.org/obo/PR_P10415

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Ontology Information

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PRO ID

PR:P10415

PRO name

apoptosis regulator Bcl-2 (human)

Synonyms

PRO-Short-label:	EXACT:	hBCL2
Gene-based:	RELATED:	BCL2

Definition

"An apoptosis regulator Bcl-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10415]

PRO Category

organism-gene

Parent

PR:000002307 apoptosis regulator Bcl-2
PR:000029067 Homo sapiens protein

Gene Template

HGNC:990 BCL2 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	2
Modification	0	Organism-Modification	6

Term Hierarchy
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OLS:

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Related Cross References
Db identifiers	UniProtKB:P10415

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

organism-gene

PR:P10415 apoptosis regulator Bcl-2 (human), hBCL2

organism-sequence

PR:P10415-1 apoptosis regulator Bcl-2 isoform Alpha (human), hBCL2/iso:Alpha

organism-modification

PR:000027461 apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human), hBCL2/iso:1/Phos:2

organism-modification

PR:000027463 apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human), hBCL2/iso:1/Phos:3

organism-modification

PR:000027465 apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human), hBCL2/iso:1/Phos:4

organism-modification

PR:000027467 apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human), hBCL2/iso:1/Phos:5

organism-sequence

PR:P10415-2 apoptosis regulator Bcl-2 isoform Beta (human), hBCL2/iso:Beta

organism-modification

PR:000070038 apoptosis regulator Bcl-2 methylated 1 (human), hBCL2/Me:1

organism-modification

PR:000082889 apoptosis regulator Bcl-2 cysteinylated 1 (human), hBCL2/Cyst:1

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000027461 hBCL2/iso:1/Phos:2 UniProtKB:P10415-1, Thr-74, MOD:00047 "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 in human. UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]	acts_upstream_of_or_within	GO:0043066 negative regulation of apoptotic process	PMID:12039864
PR:000027463 hBCL2/iso:1/Phos:3 UniProtKB:P10415-1, Thr-69, MOD:00047\|Ser-70/Ser-87, MOD:00046 "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 in human. UniProtKB:P10415-1, Thr-69, MOD:00047\|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]	acts_upstream_of_or_within	GO:0016239 positive regulation of macroautophagy	PMID:18570871; PMID:19029119
	enables	NOT GO:0005515 protein binding with PR:Q14457 BECN1	PMID:18570871; PMID:19029119
PR:000027465 hBCL2/iso:1/Phos:4 UniProtKB:P10415-1, Thr-69, MOD:00047\|Ser-87, MOD:00046 "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 in human. UniProtKB:P10415-1, Thr-69, MOD:00047\|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]	acts_upstream_of_or_within	GO:0043065 positive regulation of apoptotic process	PMID:15703383
PR:000027467 hBCL2/iso:1/Phos:5 UniProtKB:P10415-1, Thr-56, MOD:00047 "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 in human. UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]	acts_upstream_of_or_within	GO:0045839 negative regulation of mitotic nuclear division	PMID:10766756
PR:P10415-1 hBCL2/iso:Alpha "An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of human." [PRO:JAN]	acts_upstream_of_or_within	GO:0070885 negative regulation of calcineurin-NFAT signaling cascade	PMID:9109491
	enables	GO:0005515 protein binding with PR:P63328 calcineurin A alpha (mouse)	PMID:9109491
	enables	GO:0005515 protein binding with PR:Q07813 Bax	PMID:9109491
	located_in	GO:0005886 plasma membrane	PMID:9109491