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Protein Ontology report - ezrin (human)
PR:P15311 - http://purl.obolibrary.org/obo/PR_P15311
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P15311   
  PRO nameezrin (human) 
  Synonyms
PRO-Short-label: EXACT:hEZR
Gene-based: RELATED:EZR | VIL2
Other: EXACT:cytovillin (human) | villin-2 (human)
  Definition"An ezrin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P15311] 
  PRO Categoryorganism-gene 
  ParentPR:000001031
PR:000029067
  Gene TemplateHGNC:12691 EZR (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P15311
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P15311 ezrin (human), hEZR

organism-sequence


PR:P15311-1 ezrin isoform 1 (human), hEZR/iso:1

organism-modification


PR:000036588 ezrin isoform 1 phosphorylated 1 (human), hEZR/iso:1/Phos:1

organism-modification


PR:000036589 ezrin isoform 1 phosphorylated 2 (human), hEZR/iso:1/Phos:2
Yes
organism-modification


PR:000036590 ezrin isoform 1 phosphorylated 3 (human), hEZR/iso:1/Phos:3
Yes
organism-modification


PR:000036591 ezrin isoform 1 phosphorylated 4 (human), hEZR/iso:1/Phos:4

organism-modification


PR:000036592 ezrin isoform 1 phosphorylated 5 (human), hEZR/iso:1/Phos:5
Yes
organism-modification


PR:000036625 ezrin isoform 1 phosphorylated 6 (human), hEZR/iso:1/Phos:6
Yes
organism-modification


PR:000047345 ezrin, initiator methionine removed phosphorylated 5 (human), hEZR/InitMet-/Phos:5

organism-modification


PR:000047346 ezrin, initiator methionine removed phosphorylated 1 (human), hEZR/InitMet-/Phos:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036589
hEZR/iso:1/Phos:2
UniProtKB:P15311-1, Ser-66, MOD:00046		 enablesGO:0005515 protein binding with PR:000002696 WWOX/iso:1/UnMod PMID:16438931
PR:000036590
hEZR/iso:1/Phos:3
UniProtKB:P15311-1, Tyr-191, MOD:00048		 enablesGO:0005515 protein binding with PR:P00523-1 PMID:15647376
PR:000036592
hEZR/iso:1/Phos:5
UniProtKB:P15311-1, Thr-567, MOD:00047		 acts_upstream_of_or_withinGO:0001771 immunological synapse formation PMID:18025306
GO:0051279 regulation of release of sequestered calcium ion into cytosol PMID:18025306
enablesGO:0005515 protein binding with PR:P43403 70 kDa zeta-chain associated protein (human) PMID:18025306
located_inGO:0001772 immunological synapse PMID:18025306
GO:0045177 apical part of cell PMID:16144865
PR:000036625
hEZR/iso:1/Phos:6
UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047		 enablesGO:0003779 actin binding PMID:18852256
located_inGO:0002102 podosome PMID:18852256
GO:0005886 plasma membrane PMID:18852256