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Protein Ontology report - TGF-beta receptor type-1 (human)
PR:P36897 - http://purl.obolibrary.org/obo/PR_P36897
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P36897   
  PRO nameTGF-beta receptor type-1 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFBR1
Gene-based: RELATED:ALK5 | SKR4 | TGFBR1
Other: EXACT:activin A receptor type II-like protein kinase of 53kD (human) | activin receptor-like kinase 5 (human) | ALK-5 (human) | serine/threonine-protein kinase receptor R4 (human) | TbetaR-I (human) | TGF-beta receptor type I (human) | TGF-beta type I receptor (human) | TGFR-1 (human) | transforming growth factor-beta receptor type I (human)
  Definition"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36897] 
  PRO Categoryorganism-gene 
  ParentPR:000000047 TGF-beta receptor type-1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11772 TGFBR1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 14                                        
         Modification0                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P36897
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P36897 TGF-beta receptor type-1 (human)
hTGFBR1

organism-sequence


PR:000000186 TGF-beta receptor type-1 sequence variant T200I (human)
hTGFBR1/var:T200I
Yes
organism-sequence


PR:000000187 TGF-beta receptor type-1 sequence variant 10 (human)
hTGFBR1/var:10
Yes
organism-sequence


PR:000000188 TGF-beta receptor type-1 sequence variant 11 (human)
hTGFBR1/var:11
Yes
organism-sequence


PR:000000189 TGF-beta receptor type-1 sequence variant K232E (human)
hTGFBR1/var:K232E
Yes
organism-sequence


PR:000000190 TGF-beta receptor type-1 sequence variant S241L (human)
hTGFBR1/var:S241L
Yes
organism-sequence


PR:000000191 TGF-beta receptor type-1 sequence variant N267H (human)
hTGFBR1/var:N267H
Yes
organism-sequence


PR:000000192 TGF-beta receptor type-1 sequence variant M318R (human)
hTGFBR1/var:M318R
Yes
organism-sequence


PR:000000193 TGF-beta receptor type-1 sequence variant D400G (human)
hTGFBR1/var:D400G
Yes
organism-sequence


PR:000000194 TGF-beta receptor type-1 sequence variant R487P (human)
hTGFBR1/var:R487P
Yes
organism-sequence


PR:000000195 TGF-beta receptor type-1 sequence variant R487E (human)
hTGFBR1/var:R487E
Yes
organism-sequence


PR:000000196 TGF-beta receptor type-1 sequence variant R487W (human)
hTGFBR1/var:R487W
Yes
organism-sequence


PR:P36897-1 TGF-beta receptor type-1 isoform 1 (human)
hTGFBR1/iso:1
Yes
organism-modification


PR:000036432 TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
Yes
organism-modification


PR:000025959 TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
Yes
Yes
organism-sequence


PR:P36897-2 TGF-beta receptor type-1 isoform h2 (human)
hTGFBR1/iso:h2

organism-sequence


PR:P36897-3 TGF-beta receptor type-1 isoform h3 (human)
hTGFBR1/iso:h3

organism-modification


PR:000049432 TGF-beta receptor type-1, signal peptide removed form (human)
hTGFBR1/SigPep-

organism-modification


PR:000036432 TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
Yes
organism-modification


PR:000025959 TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
Yes
Yes
organism-modification


PR:000049433 TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+

organism-modification


PR:000049433 TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+

organism-modification


PR:000060809 TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)
hTGFBR1/var:G52R/SigPep-

organism-modification


PR:000060890 TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:R414*/SigPep-/Phos:1

organism-modification


PR:000061254 TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)
hTGFBR1/var:P83L/SigPep-

organism-modification


PR:000061891 TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)
hTGFBR1/var:P83S/SigPep-

organism-modification


PR:000063489 TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)
hTGFBR1/var:C41Y/SigPep-

organism-modification


PR:000063569 TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)
hTGFBR1/var:N45S/SigPep-

organism-modification


PR:000064307 TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:W242*/SigPep-/Phos:1

organism-modification


PR:000067321 TGF-beta receptor type-1 methylated 1 (human)
hTGFBR1/Me:1

organism-modification


PR:000070298 TGF-beta receptor type-1 methylated 2 (human)
hTGFBR1/Me:2

organism-modification


PR:000075184 TGF-beta receptor type-1 cysteinylated 1 (human)
hTGFBR1/Cyst:1

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hTGFBR1 forms found in complexes   

hTGFBR1 Component
 Complexes
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PR:000025961 transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000186 hTGFBR1/var:T200I
UniProtKB:P36897, Thr-200, CHEBI:30009		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000187 hTGFBR1/var:10 located_inSO:0001605 amino_acid_insertion PMID:9661882
PR:000000188 hTGFBR1/var:11
UniProtKB:P36897, 1-23, 27-503		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9661882
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:9661882
PR:000000189 hTGFBR1/var:K232E
Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:16928994
PR:000000190 hTGFBR1/var:S241L
Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:16596670; PMID:16791849
PR:000000191 hTGFBR1/var:N267H
Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:16791849
PR:000000192 hTGFBR1/var:M318R
Example: UniProtKB:P36897-1, Met-318, CHEBI:29952		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000193 hTGFBR1/var:D400G
Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000194 hTGFBR1/var:R487P
Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342		 associated_with_disease_progressionDO:14756 vascular type Ehlers-Danlos syndrome PMID:15731757; PMID:16928994
PR:000000195 hTGFBR1/var:R487E
Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:16791849; PMID:16928994
PR:000000196 hTGFBR1/var:R487W
Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954		 associated_with_disease_progressionDO:14756 vascular type Ehlers-Danlos syndrome PMID:16928994
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:7774578
GO:0007165 signal transduction PMID:8242743
GO:0007181 transforming growth factor beta receptor complex assembly PMID:8947046
enablesGO:0005025 transforming growth factor beta receptor activity, type I PMID:7774578; PMID:8947046
located_inGO:0005886 plasma membrane PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep-
UniProtKB:P36897-1, 34-503		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8242743
GO:0007181 transforming growth factor beta receptor complex assembly PMID:8242743
located_inGO:0005886 plasma membrane PMID:8242743
PR:P36897-1 hTGFBR1/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8242743