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Protein Ontology report - transforming growth factor beta-2 (human)
PR:P61812 - http://purl.obolibrary.org/obo/PR_P61812
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P61812   
  PRO nametransforming growth factor beta-2 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFB2
Gene-based: RELATED:TGFB2
Other: EXACT:cetermin (human) | G-TSF (human) | glioblastoma-derived T-cell suppressor factor (human)
  Definition"A TGF-beta 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P61812] 
  PRO Categoryorganism-gene 
  ParentPR:000000183 TGF-beta 2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11768 TGFB2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P61812
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P61812 transforming growth factor beta-2 (human), hTGFB2

organism-sequence


PR:P61812-1 transforming growth factor beta-2 isoform A (human), hTGFB2/iso:A
Yes
organism-modification


PR:000036530 TGF-beta 2 isoform A cleaved 1 (human), hTGFB2/iso:A/Clv:1
Yes
organism-modification


PR:000036532 TGF-beta 2 isoform A cleaved 2 (human), hTGFB2/iso:A/Clv:2
Yes
organism-modification


PR:000036533 TGF-beta 2 isoform A cleaved 3 (human), hTGFB2/iso:A/Clv:3
Yes
organism-sequence


PR:P61812-2 transforming growth factor beta-2 isoform B (human), hTGFB2/iso:B
Yes
organism-modification


PR:000036534 TGF-beta 2 isoform B cleaved 1 (human), hTGFB2/iso:B/Clv:1
Yes
organism-modification


PR:000036535 TGF-beta 2 isoform B cleaved 2 (human), hTGFB2/iso:B/Clv:2
Yes
organism-modification


PR:000069517 transforming growth factor beta-2 methylated 1 (human), hTGFB2/Me:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036530 hTGFB2/iso:A/Clv:1
UniProtKB:P61812-1, 303-414 | PRO_0000033785
"A TGF-beta 2 isoform A cleaved 1 in human. UniProtKB:P61812-1, 303-414." [PMID:15944186, PMID:16227582, PMID:2119582, PMID:3162913, PMID:3476488, PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
GO:0008285 negative regulation of cell population proliferation PMID:15944186
enablesGO:0001540 amyloid-beta binding PMID:16227582
GO:0005160 transforming growth factor beta receptor binding PMID:16227582
GO:0042803 protein homodimerization activity PMID:2119582; PMID:3476488
located_inGO:0005615 extracellular space PMID:3162913
PR:000036532 hTGFB2/iso:A/Clv:2
UniProtKB:P61812-1, 20-302
"A TGF-beta 2 isoform A cleaved 2 in human. UniProtKB:P61812-1, 20-302." [PMID:3162913, PRO:CNA]		 located_inGO:0032991 protein-containing complex PMID:3162913
PR:000036533 hTGFB2/iso:A/Clv:3
UniProtKB:P61812-1, 20-302, 303-414
"A TGF-beta 2 isoform A cleaved 3 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-1, 20-302, 303-414." [PMID:3162913, PMID:3476488, PRO:CNA]		 enablesGO:0042803 protein homodimerization activity PMID:3476488
located_inGO:0005615 extracellular space PMID:3162913
PR:000036534 hTGFB2/iso:B/Clv:1
UniProtKB:P61812-2, 331-442
"A TGF-beta 2 isoform B cleaved 1 in human. UniProtKB:P61812-2, 331-442." [PMID:1777240, PRO:CNA]		 located_inGO:0005615 extracellular space PMID:1777240
PR:000036535 hTGFB2/iso:B/Clv:2
UniProtKB:P61812-2, 20-330, 331-442
"A TGF-beta 2 isoform B cleaved 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-2, 20-330, 331-442." [PMID:1777240, PRO:CNA]		 located_inGO:0005615 extracellular space PMID:1777240
PR:P61812-1 hTGFB2/iso:A
TGFB2 isoform 1 (human)
"A TGF-beta 2 isoform A that is encoded in the genome of human." [PRO:CNA]		 enablesGO:0046982 protein heterodimerization activity PMID:2119582
PR:P61812-2 hTGFB2/iso:B

"A TGF-beta 2 isoform B that is encoded in the genome of human." [PRO:CNA]		 enablesGO:0046982 protein heterodimerization activity PMID:17845732
located_inGO:0045177 apical part of cell PMID:17845732