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Protein Ontology report - mothers against decapentaplegic homolog 4 isoform 1 (human)
PR:Q13485-1 -
http://purl.obolibrary.org/obo/PR_Q13485-1
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:Q13485-1
PRO name
mothers against decapentaplegic homolog 4 isoform 1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hSMAD4/iso:1
Definition
"A smad4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
PRO Category
organism-sequence
Parent
PR:000000366
PR:Q13485
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:Q13485-1
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-sequence
PR:Q13485-1
mothers against decapentaplegic homolog 4 isoform 1 (human), hSMAD4/iso:1
Yes
Yes
organism-modification
PR:000025956
mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human), hSMAD4/iso:1/MonoUbiq:1
organism-modification
PR:000025958
mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human), hSMAD4/iso:1/MonoUbiq:2
Yes
organism-modification
PR:000036483
mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human), hSMAD4/iso:1/Phos:1
Yes
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hSMAD4/iso:1
forms found in complexes
hSMAD4/iso:1
Component
Complexes
PR:Q13485ZDASHZ1
hSMAD4/iso:1
PR:000025940^P000025946^P000025947^P000025951^P000025952
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025958
hSMAD4/iso:1/MonoUbiq:2
UniProtKB:Q13485-1, Lys-519, MOD:01148
acts_upstream_of_or_within
GO:0030512
negative regulation of transforming growth factor beta receptor signaling pathway
PMID:19135894
enables
NOT
GO:0046332
SMAD binding
PMID:19135894
PR:000036483
hSMAD4/iso:1/Phos:1
UniProtKB:Q13485-1, Thr-277, MOD:00047
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:12801888
enables
increased
GO:0003700
DNA-binding transcription factor activity
relative to
PR:000002539
SMAD4/iso:1/UnMod
PMID:12801888
located_in
GO:0005634
nucleus
PMID:12801888
PR:Q13485-1
hSMAD4/iso:1
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:17142805
;
PMID:8774881
GO:0030509
BMP signaling pathway
PMID:14633973
GO:0060395
SMAD protein signal transduction
PMID:10980615
;
PMID:15350224
;
PMID:9346966
enables
GO:0003700
DNA-binding transcription factor activity
PMID:10823886
GO:0003712
transcription coregulator activity
PMID:10980615
located_in
GO:0005634
nucleus
PMID:10980615
;
PMID:15280432
GO:0005667
transcription factor complex
PMID:12374795
GO:0005737
cytoplasm
PMID:15280432