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Protein Ontology report - mothers against decapentaplegic homolog 4 isoform 1 (human)
PR:Q13485-1 - http://purl.obolibrary.org/obo/PR_Q13485-1
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q13485-1   
  PRO namemothers against decapentaplegic homolog 4 isoform 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD4/iso:1
  Definition"A smad4 isoform 1 that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-sequence 
  ParentPR:000000366
PR:Q13485
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13485-1
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
organism-sequence



PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human), hSMAD4/iso:1

Yes

Yes
organism-modification



PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human), hSMAD4/iso:1/MonoUbiq:1


organism-modification



PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human), hSMAD4/iso:1/MonoUbiq:2

Yes

organism-modification



PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human), hSMAD4/iso:1/Phos:1

Yes

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hSMAD4/iso:1 forms found in complexes   

hSMAD4/iso:1 Component
Complexes
PR:Q13485ZDASHZ1 hSMAD4/iso:1 PR:000025940^P000025946^P000025947^P000025951^P000025952
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025958
hSMAD4/iso:1/MonoUbiq:2
UniProtKB:Q13485-1, Lys-519, MOD:01148
acts_upstream_of_or_withinGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894
enablesNOT GO:0046332 SMAD binding PMID:19135894
PR:000036483
hSMAD4/iso:1/Phos:1
UniProtKB:Q13485-1, Thr-277, MOD:00047
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888
enablesincreased GO:0003700 DNA-binding transcription factor activity relative to PR:000002539 SMAD4/iso:1/UnMod PMID:12801888
located_inGO:0005634 nucleus PMID:12801888
PR:Q13485-1
hSMAD4/iso:1
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805; PMID:8774881
GO:0030509 BMP signaling pathway PMID:14633973
GO:0060395 SMAD protein signal transduction PMID:10980615; PMID:15350224; PMID:9346966
enablesGO:0003700 DNA-binding transcription factor activity PMID:10823886
GO:0003712 transcription coregulator activity PMID:10980615
located_inGO:0005634 nucleus PMID:10980615; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
GO:0005737 cytoplasm PMID:15280432