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Protein Ontology report - pro-neuregulin-1, membrane-bound isoform (mouse)

PR:Q6DR98 - http://purl.obolibrary.org/obo/PR_Q6DR98

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

GPI

PRO ID

PR:Q6DR98

PRO name

pro-neuregulin-1, membrane-bound isoform (mouse)

Synonyms

PRO-Short-label:	EXACT:	mNRG1
Gene-based:	NARROW:	Nrg1
Other:	EXACT:	pro-NRG1 (mouse)

Definition

"A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of mouse." [PRO:KRC]

PRO Category

organism-gene

Parent

PR:000029032
PR:000029649

Gene Template

MGI:96083 Nrg1 (mouse)

Taxon

NCBITaxon:10090 Mus musculus

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	9
Modification	0	Organism-Modification	8

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	UniProtKB:Q6DR98

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

organism-gene

PR:Q6DR98 pro-neuregulin-1, membrane-bound isoform (mouse), mNRG1

Yes

organism-sequence

PR:000044837 neuregulin-1 type I-beta4a (mouse), mNRG1/iso:Ibeta4a

organism-modification

PR:000044838 neuregulin-1 type I-beta4a transmembrane precursor (mouse), mNRG1/iso:Ibeta4a/precursor

organism-modification

PR:000044839 neuregulin-1 type I-beta4a mature form (mouse), mNRG1/iso:Ibeta4a/mature

union

PR:000044840 neuregulin-1 type III (mouse), mNRG1/iso:III

Yes

PR:A0A140LIG9 ,

PR:A0A5F8MPT0 ,

PR:Q6DR99 ,

organism-sequence

PR:A0A140LIG9 neuregulin-1 type III-beta1c (mouse), mNRG1/iso:IIIbeta1c

organism-sequence

PR:Q3URY7 neuregulin-1 type III-beta1c sequence variant S499Y (mouse), mNRG1/iso:IIIbeta1c/var:S499Y

organism-modification

PR:000044825 neuregulin-1 type III-beta1c transmembrane precursor (mouse), mNRG1/iso:IIIbeta1c/precursor

organism-sequence

PR:A0A140LIP8 neuregulin-1 type beta2 (mouse), mNRG1/iso:beta2

organism-sequence

PR:A0A140LJC1 neuregulin-1 type I-alpha2a (mouse), mNRG1/iso:Ialpha2a

organism-modification

PR:000044842 neuregulin-1 type I-alpha2a transmembrane precursor (mouse), mNRG1/iso:Ialpha2a/precursor

organism-sequence

PR:A0A5F8MPT0 neuregulin-1 type III-beta3 (mouse), mNRG1/iso:IIIbeta3

organism-sequence

PR:Q8BX76 neuregulin-1 type III-beta3 sequence variant D40N (mouse), mNRG1/iso:IIIbeta3/var:D40N

organism-sequence

PR:Q6DR98-1 neuregulin-1 type I-beta1a (mouse), mNRG1/iso:Ibeta1a

organism-modification

PR:000044821 neuregulin-1 type I-beta1a mature form (mouse), mNRG1/iso:Ibeta1a/mature

Yes

organism-modification

PR:000044823 neuregulin-1 type I-beta1a transmembrane precursor (mouse), mNRG1/iso:Ibeta1a/precursor

organism-sequence

PR:Q6DR99 neuregulin-1 type III-beta1a (mouse), mNRG1/iso:IIIbeta1a

Yes

organism-modification

PR:000044824 neuregulin-1 type III-beta1a transmembrane precursor (mouse), mNRG1/iso:IIIbeta1a/precursor

Yes

organism-modification

PR:000044843 neuregulin-1 intracellular domain (mouse), mNRG1/Clv:intracellular

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000044821 mNRG1/iso:Ibeta1a/mature neuregulin beta1a mature form (mouse) \| NRG beta1a mature form (mouse)	acts_upstream_of_or_within	GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation	MGI:3625788; PMID:11116142
	located_in	GO:0005576 extracellular region	MGI:3625788; PMID:11116142
PR:000044824 mNRG1/iso:IIIbeta1a/precursor neuregulin type III-beta1a precursor (mouse) \| NRG type III-beta1a precursor (mouse)	acts_upstream_of_or_within	GO:0045773 positive regulation of axon extension	MGI:4461331; PMID:20610754
PR:000044840 mNRG1/iso:III	acts_upstream_of_or_within	GO:0001964 startle response	MGI:3803029; PMID:18596162
		GO:0008366 axon ensheathment	MGI:3590355; PMID:16129398
		GO:0031643 positive regulation of myelination	MGI:4420197; PMID:18080294
		GO:0031643 positive regulation of myelination	MGI:4420197; PMID:18080294
		NOT GO:0048709 oligodendrocyte differentiation	MGI:4420197; PMID:18080294
		GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	MGI:3796800; PMID:18458158
		GO:0060999 positive regulation of dendritic spine development	MGI:4461331; PMID:20610754
		GO:0060999 positive regulation of dendritic spine development	MGI:4461331; PMID:20610754
		GO:2000010 positive regulation of protein localization to cell surface	MGI:3796800; PMID:18458158
	located_in	GO:0030424 axon	MGI:4461331; PMID:20610754
		GO:0030424 axon	MGI:4461331; PMID:20610754
		GO:0030425 dendrite	MGI:4461331; PMID:20610754
		GO:0030673 axolemma	MGI:3796800; PMID:18458158
		GO:0044297 cell body	MGI:4461331; PMID:20610754
PR:000044843 mNRG1/Clv:intracellular UniProtKB:Q6DR99, 326-700 \| NRG1 ICD (mouse)	acts_upstream_of_or_within	GO:0022008 neurogenesis	MGI:4438553; PMID:19781646
		GO:0022008 neurogenesis	MGI:4438553; PMID:19781646
		NOT GO:0045773 positive regulation of axon extension	MGI:4461331; PMID:20610754
		GO:0045944 positive regulation of transcription by RNA polymerase II	MGI:4461331; PMID:20610754
	enables	GO:0005515 protein binding with PR:O54941 Baf57	MGI:4438553; PMID:19781646
	located_in	GO:0005634 nucleus	MGI:4461331; PMID:20610754
PR:Q6DR98 mNRG1 Nrg1 \| pro-NRG1 (mouse)	acts_upstream_of_or_within	NOT GO:0031643 positive regulation of myelination	MGI:3042336; PMID:15044753
PR:Q6DR98 mNRG1 Nrg1 \| pro-NRG1 (mouse)	located_in	GO:0009897 external side of plasma membrane	MGI:3625788; PMID:11116142
PR:Q6DR99 mNRG1/iso:IIIbeta1a neuregulin-1 type III beta1-a (mouse)	acts_upstream_of_or_within	GO:0031643 positive regulation of myelination	MGI:3042336; PMID:15044753