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Protein Ontology report - serine/threonine-protein kinase STK11 (mouse)
PR:Q9WTK7 - http://purl.obolibrary.org/obo/PR_Q9WTK7
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q9WTK7   
  PRO nameserine/threonine-protein kinase STK11 (mouse) 
  Synonyms
PRO-Short-label: EXACT:mSTK11
Gene-based: RELATED:Lkb1 | Stk11
Other: EXACT:liver kinase B1 homolog (mouse) | LKB1 (mouse) | mLKB1
  Definition"A serine/threonine-protein kinase STK11 that is encoded in the genome of mouse." [OMA:Q9WTK7, PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000015740 serine/threonine-protein kinase STK11
PR:000029032 Mus musculus protein
  Gene TemplateMGI:1341870 Stk11 (mouse)
  TaxonNCBITaxon:10090 Mus musculus
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q9WTK7
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q9WTK7 serine/threonine-protein kinase STK11 (mouse), mSTK11

organism-sequence


PR:Q9WTK7-1 serine/threonine-protein kinase STK11 isoform 1 (mouse), mSTK11/iso:1
Yes
Yes
organism-modification


PR:000036893 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse), mSTK11/iso:1/Phos:1
Yes
organism-modification


PR:000036995 serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse), mSTK11/iso:1/Phos:2
Yes
organism-modification


PR:000036997 serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse), mSTK11/iso:1/UnPhos:1
Yes
organism-modification


PR:000045394 serine/threonine-protein kinase STK11 isoform 1 farnesylated 1 (mouse), mSTK11/iso:1/Farn:1

organism-modification


PR:000045395 serine/threonine-protein kinase STK11 isoform 1 farnesylated and phosphorylated 1 (mouse), mSTK11/iso:1/FarnPhos:1

organism-sequence


PR:Q9WTK7-2 serine/threonine-protein kinase STK11 isoform 2 (mouse), mSTK11/iso:2
Yes
Yes
organism-sequence


PR:Q9WTK7-3 serine/threonine-protein kinase STK11 isoform m3 (mouse), mSTK11/iso:m3

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mSTK11 forms found in complexes   

mSTK11 Component
 Complexes
PR:Q9WTK7ZDASHZ1 mSTK11/iso:1 PR:000025037 Stk11 isoform 1:Strada:Cab39 heterotrimer (mouse)
PR:Q9WTK7ZDASHZ2 mSTK11/iso:2 PR:000025038 Stk11 isoform 2:Strada:Cab39 heterotrimer (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036893 mSTK11/iso:1/Phos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048 | LKB1 tyrosine phosphorylated
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC]		 located_inGO:0005634 nucleus MGI:4439241; PMID:20142099
PR:000036995 mSTK11/iso:1/Phos:2
UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048 | LKB1(L) tyrosine phosphorylated
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC]		 acts_upstream_of_or_withinGO:0036399 TCR signalosome assembly MGI:5003385; PMID:21487392
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI:5003385; PMID:21487392
located_inGO:0036398 TCR signalosome MGI:5003385; PMID:21487392
PR:000036997 mSTK11/iso:1/UnPhos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291
"A serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC]		 located_inGO:0005737 cytoplasm MGI:4439241; PMID:20142099
PR:Q9WTK7-1 mSTK11/iso:1
mLKB1(L) | mLKB1L
"A serine/threonine-protein kinase STK11 isoform 1 that is encoded in the genome of mouse. This isoform includes the sequence encoded by exon IXa. This isoform is widely expressed." [PRO:KRC]		 acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI:3836081; PMID:18854309
GO:0016020 membrane MGI:3836081; PMID:18854309
PR:Q9WTK7-2 mSTK11/iso:2
mLKB1(S) | mLKB1S
"A serine/threonine-protein kinase STK11 isoform 2 that is encoded in the genome of mouse. This isoform is shorter than isoform 1 at the C-terminal region due to usage of exon IXb. This isoform has predominant expression in the testis." [PMID:18854309, PRO:KRC]		 located_inGO:0005737 cytoplasm MGI:3836081; PMID:18854309