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Protein Ontology report - potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
PR:Q9Y3Q4 - http://purl.obolibrary.org/obo/PR_Q9Y3Q4
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q9Y3Q4   
  PRO namepotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) 
  Synonyms
PRO-Short-label: EXACT:hHCN4
Gene-based: RELATED:HCN4
  Definition"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y3Q4] 
  PRO Categoryorganism-gene 
  ParentPR:000000708
PR:000029067
  Gene TemplateHGNC:16882 HCN4 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q9Y3Q4
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q9Y3Q4 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human), hHCN4

organism-sequence


PR:000000759 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human), hHCN4/var:D553N
Yes
organism-sequence


PR:000000760 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human), hHCN4/var:S672R
Yes
organism-sequence


PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human), hHCN4/iso:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000759
hHCN4/var:D553N
UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347 | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 1 (human)		 associated_with_disease_progressionDO:13884 sick sinus syndrome PMID:15123648
located_inNOT GO:0005886 plasma membrane PMID:15123648
PR:000000760
hHCN4/var:S672R
UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952 | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human)		 associated_with_disease_progressionDO:13884 sick sinus syndrome PMID:16407510
enablesGO:0005222 intracellular cAMP-activated cation channel activity PMID:16407510
altered GO:0022843 voltage-gated monoatomic cation channel activity relative to PR:000002604 HCN4/iso:1/UnMod PMID:16407510
PR:Q9Y3Q4-1
hHCN4/iso:1
 acts_upstream_of_or_withinGO:0006812 monoatomic cation transport PMID:10228147
GO:0006936 muscle contraction PMID:10228147
enablesGO:0005261 monoatomic cation channel activity PMID:10228147