part_of
energy homeostasis pathway
leptin system pathway
Leptin acts on two populations of hypothalamic neurons that express orexigenic (feeding inducing) and anorexigenic genes, respectively. Leptin reduces the expression of genes from the former and enhances the expression of genes from the latter neurons. The leptin mediated response acts primarily via Jak-dependent activation of STAT.
PW:0000363
Signaling by Leptin
leptin-mediated signaling pathway
pathway
peptide and protein hormone signaling pathway