stress response pathway
p53-dependent G1/S DNA damage checkpoint pathway
transcription factor mediated signaling pathway
p53 signaling pathway
2009-11-30T03:01:53Z
KEGG:04115
PID:200206
PW:0000718
VPetri
p53 transcription factor is a tumor suppressor frequently mutated in cancer. p53 is at the hub of many signaling and regulatory pathways. In response to various stresses, it promotes apoptosis, cell cycle arrest and other defense pathways via transcription dependent as well as independent routes. A key regulator of p53 is Mdm2. Mdm2 is a transcriptional target of p53 thus providing a negative feedback loop.
pathway
transcription pathway via transcription factor mediated signaling