carbohydrate metabolic pathway
glucose reduction pathway
polyol pathway
2014-03-20T09:06:03Z
PW:0001518
PW:0001520
The polyol pathway is triggered by excess glucose which is reduced to sorbitol in the first step which requires NADPH as a cofactor. Sorbitol is eventually converted to fructose. Sorbitol, which is membrane impermeable and metabolites of fructose which can lead to the production of AGEs (advance glycation endproduct), along with other pathways affected by a hyperglycemic state are thought to be associated with the pathophysiology of diabetic retinopathy. The intermediate sorbitol in the pathway is a sugar alcohol; sugar alcohols are a class of polyols - alcohol molecules with multiple hydroxyl groups.
VPetri
pathway
sorbitol-aldose reductase pathway