format-version: 1.2 date: 13:02:2024 09:12 saved-by: CARD auto-generated-by: cv2obo default-namespace: antibiotic_resistance ontology: antibiotic_resistance [Term] id: ARO:0000000 name: macrolide antibiotic namespace: antibiotic_resistance def: "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins." [PMID:15544496, PMID:27480866, PMID:11324679] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:0000001 name: fluoroquinolone antibiotic namespace: antibiotic_resistance def: "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death." [PMID:23010009, PMID:3311572, PMID:3802748] is_a: ARO:1000003 ! antibiotic molecule synonym: "fluoroquinolone" EXACT [] synonym: "quinolone" EXACT [] [Term] id: ARO:0000002 name: tetracycline-resistant ribosomal protection protein namespace: antibiotic_resistance def: "A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein." [] is_a: ARO:3000185 ! antibiotic target protection protein relationship: confers_resistance_to_drug_class ARO:3000050 ! tetracycline antibiotic [Term] id: ARO:0000003 name: astromicin namespace: antibiotic_resistance def: "Astromicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Astromicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:11083623, PMID:8385262] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "Astromicina" EXACT [] synonym: "Astromicine" EXACT [] synonym: "Astromicinum" EXACT [] synonym: "fortimicin A" EXACT [] xref: pubchem.compound:5284517 [Term] id: ARO:0000004 name: monobactam namespace: antibiotic_resistance def: "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." [PMID:11585791, PMID:3871589, PMID:02669628, PMID:15673804] is_a: ARO:3000007 ! beta-lactam antibiotic [Term] id: ARO:0000005 name: neomycin namespace: antibiotic_resistance def: "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:8385262, PMID:11083623] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "Fradiomycin" EXACT [] synonym: "Fradiomycinum" EXACT [] synonym: "Framycetinum" EXACT [] synonym: "Mycifradin" EXACT [] synonym: "Neomas" EXACT [] synonym: "Soframycin" EXACT [] synonym: "framycetin" EXACT [] synonym: "neomycin B" EXACT [] xref: pubchem.compound:8378 [Term] id: ARO:0000006 name: erythromycin namespace: antibiotic_resistance def: "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited." [PMID:15980346, PMID:7683018, PMID:10582867] is_a: ARO:0000000 ! macrolide antibiotic synonym: "Abomacetin" EXACT [] synonym: "Emgel" EXACT [] synonym: "Eritromicina" EXACT [] synonym: "Erymax" EXACT [] synonym: "Erythrocin" EXACT [] synonym: "Erythromycin A" EXACT [] synonym: "Erythromycine" EXACT [] synonym: "Erythromycinum" EXACT [] synonym: "N-methylerythromycin A" EXACT [] xref: pubchem.compound:12560 [Term] id: ARO:0000007 name: dibekacin namespace: antibiotic_resistance def: "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:11083623, PMID:8385262] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "Debecacin" EXACT [] synonym: "Dibekacina" EXACT [] synonym: "Dibekacine" EXACT [] synonym: "Dibekacinum" EXACT [] synonym: "Dideoxykanamycin B" EXACT [] synonym: "Icacine" EXACT [] synonym: "Kappati" EXACT [] synonym: "Orbicin" EXACT [] synonym: "Panamicin" EXACT [] xref: pubchem.compound:470999 [Term] id: ARO:0000008 name: cefoxitin namespace: antibiotic_resistance def: "Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases." [PMID:15673804, PMID:3487346, PMID:11585791] is_a: ARO:0000044 ! cephamycin synonym: "FOX" EXACT [] synonym: "Mefoxitin" EXACT [] synonym: "mefoxin" EXACT [] xref: pubchem.compound:441199 [Term] id: ARO:0000009 name: tunicamycin namespace: antibiotic_resistance def: "Tunicamycin is mixture of homologous nucleoside antibiotics that block the reaction of UDP-N-acetylglucosamine and dolichyl phosphate in the first step of glycoprotein synthesis." [PMID:1624425] is_a: ARO:3000034 ! nucleoside antibiotic is_a: ARO:3000707 ! antibiotic mixture xref: pubchem.compound:5354023 [Term] id: ARO:0000010 name: antibiotic resistance gene cluster, cassette, or operon namespace: antibiotic_resistance def: "Clusters of antibiotic resistance genes. May be regulated by a shared promoter or repressor." [] is_a: ARO:3000000 ! determinant of antibiotic resistance [Term] id: ARO:0000011 name: cloxacillin namespace: antibiotic_resistance def: "Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections." [PMID:15673804, PMID:1234495, PMID:11585791] is_a: ARO:3000008 ! penam synonym: "Chloroxacillin" EXACT [] synonym: "Clossacillina" EXACT [] synonym: "Cloxacilina" EXACT [] synonym: "Cloxacilline" EXACT [] synonym: "Cloxacillinum" EXACT [] synonym: "Cloxapen" EXACT [] synonym: "Methocillin S" EXACT [] synonym: "Orbenin" EXACT [] synonym: "Syntarpen" EXACT [] synonym: "Tegopen" EXACT [] xref: pubchem.compound:6098 [Term] id: ARO:0000012 name: streptothricin namespace: antibiotic_resistance def: "Streptothricins are a group of N-glycoside antibiotics that include a carbamoylated D-glucosamine to which are attached a series of L-beta-lysine residues at position 2 and a streptolidine at position 1. Streptothricins vary by the number of beta-lysine residues (from 1 (nourseothricin) to 7) and target protein synthesis in bacteria and eukaryotes." [PMID:11083623, PMID:8385262, PMID:10103173] is_a: ARO:3000034 ! nucleoside antibiotic synonym: "nourseothricin" EXACT [] synonym: "racemomycin" EXACT [] synonym: "streptothricin F" EXACT [] synonym: "yazumycin" EXACT [] xref: pubchem.compound:475825 [Term] id: ARO:0000013 name: amikacin namespace: antibiotic_resistance def: "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:11083623, PMID:8385262, PMID:10103173] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "AMK" EXACT [] synonym: "Amicacin" EXACT [] synonym: "Amikacina" EXACT [] synonym: "Amikacinum" EXACT [] synonym: "Amikavet" EXACT [] synonym: "Arikace" EXACT [] synonym: "Kaminax" EXACT [] synonym: "Lukadin" EXACT [] synonym: "Mikavir" EXACT [] synonym: "amikacine" EXACT [] synonym: "mikacin" EXACT [] xref: pubchem.compound:37768 [Term] id: ARO:0000014 name: gentamicin C namespace: antibiotic_resistance def: "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:11083623, PMID:8385262, PMID:10103173] is_a: ARO:3000707 ! antibiotic mixture is_a: ARO:3007382 ! gentamicin synonym: "Cidomycin" EXACT [] synonym: "Garamycin" EXACT [] synonym: "Gentacycol" EXACT [] synonym: "Gentamicins" EXACT [] synonym: "Gentamycinum" EXACT [] synonym: "Gentavet" EXACT [] synonym: "Gentocin" EXACT [] synonym: "Refobacin" EXACT [] synonym: "Uromycine" EXACT [] xref: pubchem.compound:3084091 [Term] id: ARO:0000015 name: methicillin namespace: antibiotic_resistance def: "Derived from penicillin to combat penicillin-resistance, methicillin is insensitive to beta-lactamases (also known as penicillinases) secreted by many penicillin-resistant bacteria. Methicillin is bactericidal, and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." [PMID:15673804, PMID:3889939, PMID:11585791] is_a: ARO:3000008 ! penam synonym: "Dimocillin" EXACT [] synonym: "Metacillin" EXACT [] synonym: "Methicillinum" EXACT [] synonym: "Methycillin" EXACT [] synonym: "Meticilina" EXACT [] synonym: "Meticilline" EXACT [] synonym: "Meticillinum" EXACT [] synonym: "Staphcillin" EXACT [] synonym: "meticillin" EXACT [] xref: pubchem.compound:6087 [Term] id: ARO:0000016 name: aminoglycoside antibiotic namespace: antibiotic_resistance def: "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:8385262, PMID:11083623, PMID:10103173] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:0000017 name: lincosamide antibiotic namespace: antibiotic_resistance def: "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides." [PMID:10582867, PMID:15135500] is_a: ARO:1000003 ! antibiotic molecule synonym: "lincosamide" EXACT [] [Term] id: ARO:0000018 name: viomycin namespace: antibiotic_resistance def: "Viomycin sulfate (Viocin) is an polypeptide antibiotic used in the treatment of tuberculosis. It is produced by the actinomycete Streptomyces puniceus and binds to the bacterial ribosome, inhibiting prokaryotic protein synthesis and certain forms of RNA splicing." [PMID:211438] is_a: ARO:3000053 ! peptide antibiotic synonym: "Celiomycin" EXACT [] synonym: "Florimycin" EXACT [] synonym: "Tuberactinomycin B" EXACT [] synonym: "Viocin" EXACT [] xref: pubchem.compound:135398671 [Term] id: ARO:0000020 name: carbapenem namespace: antibiotic_resistance def: "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." [PMID:11585791, PMID:15673804] is_a: ARO:3000007 ! beta-lactam antibiotic [Term] id: ARO:0000021 name: ribostamycin namespace: antibiotic_resistance def: "Ribostamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Ribostamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:11083623, PMID:8385262] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "dekamycin IV" EXACT [] synonym: "hetangmycin" EXACT [] synonym: "ribastamin" EXACT [] synonym: "vistamycin" EXACT [] synonym: "xylostatin" EXACT [] xref: pubchem.compound:33042 [Term] id: ARO:0000022 name: polymyxin antibiotic namespace: antibiotic_resistance def: "Polymyxins are cationic detergent antibiotics, with a general structure of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins have a bactericidal effect on Gram-negative bacilli, especially on Pseudomonas and coliform organisms." [PMID:11706007] is_a: ARO:3000035 ! lipopeptide antibiotic [Term] id: ARO:0000023 name: enoxacin namespace: antibiotic_resistance def: "Enoxacin belongs to a group called fluoroquinolones. Its mode of action depends upon blocking bacterial DNA replication by binding itself to DNA gyrase and causing double-stranded breaks in the bacterial chromosome." [PMID:15914491] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Enroxil" EXACT [] synonym: "Penetrex" EXACT [] xref: pubchem.compound:3229 [Term] id: ARO:0000024 name: butirosin namespace: antibiotic_resistance def: "Butirosin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Butirosin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:11083623, PMID:8385262, PMID:10103173] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "ambutyrosin sulfate" EXACT [] synonym: "butirosin sulphate" EXACT [] xref: pubchem.compound:72393 [Term] id: ARO:0000025 name: fosfomycin namespace: antibiotic_resistance def: "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction." [PMID:8994972, PMID:17567049, PMID:18701452, PMID:8075064, PMID:5809587] is_a: ARO:3007149 ! phosphonic acid antibiotic synonym: "(1R,2S)-1,2-epoxy-propylphosphonic acid" EXACT [] synonym: "phosphomycin" EXACT [] synonym: "phosphonomycin" EXACT [] xref: pubchem.compound:73491 [Term] id: ARO:0000026 name: streptogramin antibiotic namespace: antibiotic_resistance def: "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30." [PMID:15700955] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:0000027 name: roxithromycin namespace: antibiotic_resistance def: "Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited." [PMID:10582867, PMID:15980346] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:6915744 [Term] id: ARO:0000028 name: vancomycin namespace: antibiotic_resistance def: "Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin inhibits the synthesis of peptidoglycan, the major component of the cell wall of gram-positive bacteria. Its mechanism of action is unusual in that it acts by binding precursors of peptidoglycan, rather than by interacting with an enzyme." [PMID:16323116] is_a: ARO:3000081 ! glycopeptide antibiotic synonym: "Vancocin" EXACT [] xref: pubchem.compound:14969 [Term] id: ARO:0000029 name: teicoplanin namespace: antibiotic_resistance def: "Teicoplanin is a glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria. Teicoplanin has a unique acyl-aliphatic chain, and binds to cell wall precursors to inhibit transglycosylation and transpeptidation." [PMID:6235205, PMID:6240963, PMID:16323116, PMID:6239854, PMID:11131961] is_a: ARO:3000081 ! glycopeptide antibiotic synonym: "targocid" EXACT [] synonym: "teichomycin" EXACT [] xref: pubchem.compound:16129712 [Term] id: ARO:0000030 name: tigecycline namespace: antibiotic_resistance def: "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome." [PMID:19862477, PMID:11381101] is_a: ARO:0000042 ! glycylcycline synonym: "Tygacil" EXACT [] xref: pubchem.compound:54686904 [Term] id: ARO:0000031 name: antibiotic resistant gene variant or mutant namespace: antibiotic_resistance def: "Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:3000212 ! mutation conferring antibiotic resistance [Term] id: ARO:0000032 name: cephalosporin namespace: antibiotic_resistance def: "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." [PMID:11585791, PMID:15673804, PMID:6810737] is_a: ARO:3000276 ! cephem [Term] id: ARO:0000034 name: streptogramin A antibiotic namespace: antibiotic_resistance def: "Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics." [PMID:12102603, PMID:12860128, PMID:17015629, PMID:15700955] is_a: ARO:0000026 ! streptogramin antibiotic [Term] id: ARO:0000035 name: sisomicin namespace: antibiotic_resistance def: "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:8385262, PMID:11083623] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "antibiotic 6640" EXACT [] synonym: "dehydrogentamicin" EXACT [] synonym: "rickamicin" EXACT [] synonym: "sisomycin" EXACT [] synonym: "sissomicin" EXACT [] xref: pubchem.compound:36119 [Term] id: ARO:0000036 name: ciprofloxacin namespace: antibiotic_resistance def: "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome." [PMID:15700957, PMID:15914491] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "CIP" EXACT [] synonym: "Cipro" EXACT [] synonym: "Ciprobay" EXACT [] synonym: "Ciproxan" EXACT [] xref: pubchem.compound:2764 [Term] id: ARO:0000037 name: apramycin namespace: antibiotic_resistance def: "Apramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections in animals. Apramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:8385262, PMID:11083623] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "ambylan" EXACT [] synonym: "apralan" EXACT [] synonym: "nebramycin II" EXACT [] xref: pubchem.compound:3081545 [Term] id: ARO:0000038 name: netilmicin namespace: antibiotic_resistance def: "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin." [PMID:11083623, PMID:8385262, PMID:10103173] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "1-N-aethylsisomicin" EXACT [] synonym: "netilyn" EXACT [] synonym: "netromycin" EXACT [] synonym: "vectacin" EXACT [] xref: pubchem.compound:441306 [Term] id: ARO:0000039 name: spectinomycin namespace: antibiotic_resistance def: "Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation." [PMID:8385262, PMID:11083623, PMID:10103173] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "Actinospectacin" EXACT [] synonym: "Spectam" EXACT [] synonym: "Togamycin" EXACT [] synonym: "Trobicin" EXACT [] xref: pubchem.compound:15541 [Term] id: ARO:0000040 name: streptomycin namespace: antibiotic_resistance def: "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:11083623, PMID:8385262] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "streptomycin A sulfate" EXACT [] synonym: "streptomycin A" EXACT [] synonym: "streptomycin sulfate" EXACT [] synonym: "streptomycin sulphate" EXACT [] xref: pubchem.compound:19649 [Term] id: ARO:0000041 name: bacitracin namespace: antibiotic_resistance def: "Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Bacitracin interferes with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule which carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane." [PMID:8389741] is_a: ARO:3000053 ! peptide antibiotic is_a: ARO:3000707 ! antibiotic mixture synonym: "Altracin" EXACT [] synonym: "Ayfivin" EXACT [] synonym: "BACiiM" EXACT [] synonym: "Baciguent" EXACT [] synonym: "Baciquent" EXACT [] synonym: "Citracin" EXACT [] synonym: "Fortracin" EXACT [] synonym: "Penitracin" EXACT [] synonym: "Topitracin" EXACT [] synonym: "Zutracin" EXACT [] xref: pubchem.compound:57402735 [Term] id: ARO:0000042 name: glycylcycline namespace: antibiotic_resistance def: "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA." [PMID:11381101] is_a: ARO:3000050 ! tetracycline antibiotic [Term] id: ARO:0000043 name: carbenicillin namespace: antibiotic_resistance def: "Carbenicillin is a semi-synthetic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes. Carbenicillin antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." [PMID:15673804, PMID:4248289, PMID:11585791] is_a: ARO:3000008 ! penam synonym: "Anabactyl" EXACT [] synonym: "CAR" EXACT [] synonym: "Carbecin" EXACT [] synonym: "Carbenicilina" EXACT [] synonym: "Carbenicillina" EXACT [] synonym: "Carbenicilline" EXACT [] synonym: "Carbenicillinum" EXACT [] synonym: "Geopen" EXACT [] synonym: "Microcillin" EXACT [] synonym: "Pyopen" EXACT [] xref: pubchem.compound:20824 [Term] id: ARO:0000044 name: cephamycin namespace: antibiotic_resistance def: "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases." [PMID:11585791, PMID:3487346, PMID:15673804] is_a: ARO:3000276 ! cephem xref: pubchem.compound:123731 [Term] id: ARO:0000045 name: acriflavine namespace: antibiotic_resistance def: "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish." [PMID:11566977] is_a: ARO:3005386 ! disinfecting agents and antiseptics synonym: "Acriflavin" EXACT [] synonym: "Assiflavine" EXACT [] synonym: "Bialflavina" EXACT [] synonym: "Bioacridin" EXACT [] synonym: "Bovoflavin" EXACT [] synonym: "Buroflavin" EXACT [] synonym: "Choliflavin" EXACT [] synonym: "Euflavine" EXACT [] synonym: "Pantonsiletten" EXACT [] synonym: "Xanthacridinum" EXACT [] xref: pubchem.compound:443101 [Term] id: ARO:0000046 name: lincomycin namespace: antibiotic_resistance def: "Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction." [PMID:15135500, PMID:10582867] is_a: ARO:0000017 ! lincosamide antibiotic synonym: "Cillimycin" EXACT [] synonym: "Epilincomycin" EXACT [] synonym: "Jiemycin" EXACT [] synonym: "Lincocin" EXACT [] synonym: "Lincolcina" EXACT [] synonym: "Lincolnensin" EXACT [] synonym: "Lincomicina" EXACT [] synonym: "Lincomycin A" EXACT [] synonym: "Lincomycine" EXACT [] synonym: "Lincomycinum" EXACT [] xref: pubchem.compound:3000540 [Term] id: ARO:0000047 name: puromycin namespace: antibiotic_resistance def: "Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, that causes premature chain termination during ribosomal protein translation." [PMID:7608059] is_a: ARO:3000080 ! aminonucleoside antibiotic synonym: "Puromycin dihydrochloride" EXACT [] synonym: "Puromycin hydrochloride" EXACT [] synonym: "Stylomycin dihydrochloride" EXACT [] xref: pubchem.compound:439530 [Term] id: ARO:0000049 name: kanamycin A namespace: antibiotic_resistance def: "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:8385262, PMID:11083623] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "Aminodeoxykanamycin" EXACT [] synonym: "Aspidium" EXACT [] synonym: "Kanamicina" EXACT [] synonym: "Kanamycin sulfate" EXACT [] synonym: "Kanamycine" EXACT [] synonym: "Kanamycinum" EXACT [] synonym: "Kantrex" EXACT [] synonym: "kanamycin" EXACT [] xref: pubchem.compound:6032 [Term] id: ARO:0000050 name: streptogramin B antibiotic namespace: antibiotic_resistance def: "Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics." [PMID:9746015, PMID:15700955, PMID:10582867] is_a: ARO:0000026 ! streptogramin antibiotic [Term] id: ARO:0000051 name: tetracycline namespace: antibiotic_resistance def: "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome." [PMID:11381101, PMID:19862477] is_a: ARO:3000050 ! tetracycline antibiotic synonym: "Abricycline" EXACT [] synonym: "Achromycin" EXACT [] synonym: "Agromicina" EXACT [] synonym: "Ambramicina" EXACT [] synonym: "Ambramycin" EXACT [] synonym: "Biocycline" EXACT [] synonym: "Criseociclina" EXACT [] synonym: "Enterocycline" EXACT [] synonym: "Sumycin" EXACT [] synonym: "Tsiklomistsin" EXACT [] xref: pubchem.compound:54675776 [Term] id: ARO:0000052 name: tobramycin namespace: antibiotic_resistance def: "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth." [PMID:10103173, PMID:11083623, PMID:8385262] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "Gotabiotic" EXACT [] synonym: "Nebcin" EXACT [] synonym: "Tenebrimycin" EXACT [] synonym: "Tobracin" EXACT [] synonym: "Tobradistin" EXACT [] synonym: "Tobramaxin" EXACT [] synonym: "Tobramicin" EXACT [] synonym: "Tobramitsetin" EXACT [] synonym: "Tobramycetin" EXACT [] synonym: "Tobrex" EXACT [] xref: pubchem.compound:36294 [Term] id: ARO:0000053 name: bleomycin namespace: antibiotic_resistance def: "Bleomycin is a family of glycopeptide antibiotics produced by the bacterium Streptomyces verticillus. Bleomycins, taken as a mixture, act by the induction of DNA and RNA strand breaks. In addition to its antibacterial activity, bleomycin is also used as an anticancer agent." [PMID:15700963] is_a: ARO:3000081 ! glycopeptide antibiotic is_a: ARO:3000707 ! antibiotic mixture synonym: "Blenoxane" EXACT [] synonym: "Bleocin" EXACT [] synonym: "Bleomicin" EXACT [] synonym: "Bleomycin sulfate" EXACT [] synonym: "Isobleomycin A2" EXACT [] synonym: "cu-blenoxane" EXACT [] xref: pubchem.compound:5360373 [Term] id: ARO:0000054 name: penicillin namespace: antibiotic_resistance def: "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." [PMID:11585791, PMID:15673804] is_a: ARO:3000008 ! penam synonym: "Benzopenicillin" EXACT [] synonym: "Cilopen" EXACT [] synonym: "Dropcillin" EXACT [] synonym: "Gelacillin" EXACT [] synonym: "Liquacillin" EXACT [] synonym: "PCN" EXACT [] synonym: "Pharmacillin" EXACT [] synonym: "Pradupen" EXACT [] synonym: "Specilline G" EXACT [] synonym: "penicillin g" EXACT [] xref: pubchem.compound:2349 [Term] id: ARO:0000055 name: bicyclomycin namespace: antibiotic_resistance def: "Bicyclomycin represents a unique class of antibiotics, discovered in 1972. It is obtained by the fermentation of Streptomyces sapporonensis. In the crystalline form bicyclomycin is observed to be rhombic or monoclinic, depending on the solvent used. This antibiotic kills bacteria by inhibiting the Rho transcription terminator factor, halting ribonucleic acid (RNA) synthesis." [PMID:16181146, PMID:7487110] is_a: ARO:3007150 ! bicyclomycin-like antibiotic synonym: "Aizumycin" EXACT [] synonym: "Bacfeed" EXACT [] synonym: "Bacteron" EXACT [] synonym: "Bicozamicina" EXACT [] synonym: "Bicozamycin" EXACT [] synonym: "Bicozamycine" EXACT [] synonym: "Bicozamycinum" EXACT [] xref: pubchem.compound:65807 [Term] id: ARO:0000056 name: oxacillin namespace: antibiotic_resistance def: "Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis." [PMID:7928809] is_a: ARO:3000008 ! penam synonym: "MPI-penicillin" EXACT [] synonym: "Ossacillina" EXACT [] synonym: "Oxacilina" EXACT [] synonym: "Oxacilline" EXACT [] synonym: "Oxacillinum" EXACT [] synonym: "Oxazocillin" EXACT [] synonym: "Oxazocilline" EXACT [] synonym: "Prostaphlin" EXACT [] synonym: "Prostaphlyn" EXACT [] xref: pubchem.compound:6196 [Term] id: ARO:0000057 name: telithromycin namespace: antibiotic_resistance def: "Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis." [PMID:15700954] is_a: ARO:0000000 ! macrolide antibiotic synonym: "HMR-3647" EXACT [] synonym: "HMR3647" EXACT [] synonym: "Ketek" EXACT [] synonym: "Levviax" EXACT [] xref: pubchem.compound:3002190 [Term] id: ARO:0000058 name: cefazolin namespace: antibiotic_resistance def: "Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria." [PMID:4790605, PMID:27572414] is_a: ARO:0000032 ! cephalosporin synonym: "CFZ" EXACT [] synonym: "Cefamezin" EXACT [] synonym: "Cefazolina" EXACT [] synonym: "Cefazoline" EXACT [] synonym: "Cefazolinum" EXACT [] synonym: "Cephamezine" EXACT [] synonym: "Cephazolidin" EXACT [] synonym: "Cephazolin" EXACT [] synonym: "Cephazoline" EXACT [] synonym: "Elzogram" EXACT [] xref: pubchem.compound:33255 [Term] id: ARO:0000059 name: cefepime namespace: antibiotic_resistance def: "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents." [PMID:8150771] is_a: ARO:0000032 ! cephalosporin synonym: "Axepim" EXACT [] synonym: "Cefepima" EXACT [] synonym: "Cefepimum" EXACT [] synonym: "FEP" EXACT [] synonym: "Maxipime" EXACT [] xref: pubchem.compound:5479537 [Term] id: ARO:0000060 name: ceftazidime namespace: antibiotic_resistance def: "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections." [PMID:6805421] is_a: ARO:0000032 ! cephalosporin synonym: "CAZ" EXACT [] synonym: "Ceftazidim" EXACT [] synonym: "Ceptaz" EXACT [] synonym: "Fortaz" EXACT [] synonym: "Pentacef" EXACT [] synonym: "Tazicef" EXACT [] synonym: "Tazidime" EXACT [] synonym: "caftazidime" EXACT [] synonym: "ceftazidima" EXACT [] synonym: "ceftazidimum" EXACT [] xref: pubchem.compound:5481173 [Term] id: ARO:0000061 name: ceftobiprole namespace: antibiotic_resistance def: "Ceftobiprole (Zeftera/Zevtera) is a next generation (5th generation) cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci. Ceftobiprole inhibits transpeptidases essential to building cell walls, and is a poor substrate for most beta-lactamases." [PMID:22064544] is_a: ARO:0000032 ! cephalosporin synonym: "Ceftobiprole medocaril" EXACT [] synonym: "Zeftera" EXACT [] synonym: "Zevtera" EXACT [] xref: pubchem.compound:135413542 [Term] id: ARO:0000062 name: ceftriaxone namespace: antibiotic_resistance def: "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria." [PMID:6810737] is_a: ARO:0000032 ! cephalosporin synonym: "Biotrakson" EXACT [] synonym: "CRO" EXACT [] synonym: "Cefatriaxone" EXACT [] synonym: "Ceftriaxon" EXACT [] synonym: "Ceftriaxona" EXACT [] synonym: "Ceftriaxonum" EXACT [] synonym: "Ceftriazone" EXACT [] synonym: "Longacef" EXACT [] synonym: "Longaceph" EXACT [] synonym: "Rocephin" EXACT [] xref: pubchem.compound:5479530 [Term] id: ARO:0000063 name: cefuroxime namespace: antibiotic_resistance def: "Cefuroxime is a second-generation cephalosporin antibiotic with increased stability with beta-lactamases than first-generation cephalosporins. Cefuroxime is active against Gram-positive organisms but less active against methicillin-resistant strains." [PMID:1259408] is_a: ARO:0000032 ! cephalosporin synonym: "Biofuroksym" EXACT [] synonym: "CXM" EXACT [] synonym: "Cefuril" EXACT [] synonym: "Cefuroxim" EXACT [] synonym: "Cefuroximo" EXACT [] synonym: "Cefuroximum" EXACT [] synonym: "Cephuroxime" EXACT [] synonym: "Sharox" EXACT [] synonym: "Zinacef" EXACT [] xref: pubchem.compound:5479529 [Term] id: ARO:0000064 name: amoxicillin namespace: antibiotic_resistance def: "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan." [PMID:19236222] is_a: ARO:3000008 ! penam synonym: "AMX" EXACT [] synonym: "Amolin" EXACT [] synonym: "Amopenixin" EXACT [] synonym: "Amoxicilina" EXACT [] synonym: "Amoxicilline" EXACT [] synonym: "Amoxicillinum" EXACT [] synonym: "Amoxycillin" EXACT [] synonym: "Clamoxyl" EXACT [] synonym: "D-Amoxicillin" EXACT [] synonym: "Moxal" EXACT [] xref: pubchem.compound:33613 [Term] id: ARO:0000065 name: clarithromycin namespace: antibiotic_resistance def: "Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections." [PMID:7683018] is_a: ARO:0000000 ! macrolide antibiotic synonym: "Biaxin" EXACT [] synonym: "CLR" EXACT [] synonym: "Clambiotic" EXACT [] synonym: "Clarith" EXACT [] synonym: "Clathromycin" EXACT [] synonym: "Klacid" EXACT [] synonym: "Klaricid" EXACT [] synonym: "Macladin" EXACT [] synonym: "Naxy" EXACT [] synonym: "Veclam" EXACT [] xref: pubchem.compound:84029 [Term] id: ARO:0000066 name: clindamycin namespace: antibiotic_resistance def: "Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria." [PMID:20876128] is_a: ARO:0000017 ! lincosamide antibiotic synonym: "CLI" EXACT [] synonym: "Chlolincocin" EXACT [] synonym: "Chlorlincocin" EXACT [] synonym: "Cleocin" EXACT [] synonym: "Clindamicina" EXACT [] synonym: "Clindamycine" EXACT [] synonym: "Clindamycinum" EXACT [] synonym: "Clinimycin" EXACT [] synonym: "Sobelin" EXACT [] xref: pubchem.compound:446598 [Term] id: ARO:0000067 name: colistin namespace: antibiotic_resistance def: "Colistins are polymyxin antibiotics produced by certain strains of Bacillus polymyxa var. colistinus. Colistin, also referred to as polymyxin E, is a mixture of cyclic polypeptides colistin A and B which disrupt the bacterial cell membrane and is effective against Gram-negative bacteria." [PMID:17958555, PMID:20818945] is_a: ARO:0000022 ! polymyxin antibiotic synonym: "CST" EXACT [] synonym: "Colomycin" EXACT [] synonym: "polymyxin E" EXACT [] [Term] id: ARO:0000068 name: daptomycin namespace: antibiotic_resistance def: "Daptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Daptomycin interferes with the bacterial cell membrane, reducing membrane potential and inhibiting cell wall synthesis." [PMID:22083474, PMID:15870461, PMID:16311632, PMID:11353654, PMID:12615866, PMID:20522545, PMID:14985278] is_a: ARO:3000035 ! lipopeptide antibiotic synonym: "Cidecin" EXACT [] synonym: "Cubicin" EXACT [] synonym: "Daptomicina" EXACT [] synonym: "Daptomycine" EXACT [] synonym: "Daptomycinum" EXACT [] synonym: "Deptomycin" EXACT [] xref: pubchem.compound:16134395 [Term] id: ARO:0000069 name: doxycycline namespace: antibiotic_resistance def: "Doxycycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome." [PMID:11381101, PMID:19862477] is_a: ARO:3000050 ! tetracycline antibiotic synonym: "Azudoxat" EXACT [] synonym: "Deoxymykoin" EXACT [] synonym: "Doxiciclina" EXACT [] synonym: "Doxitard" EXACT [] synonym: "Doxycyclinum" EXACT [] synonym: "Doxytetracycline" EXACT [] synonym: "Vibramycin" EXACT [] synonym: "Vibramycine" EXACT [] synonym: "Vibravenos" EXACT [] xref: pubchem.compound:54671203 [Term] id: ARO:0000070 name: ertapenem namespace: antibiotic_resistance def: "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis." [PMID:27572414, PMID:12951340] is_a: ARO:0000020 ! carbapenem synonym: "Invanz" EXACT [] xref: pubchem.compound:150610 [Term] id: ARO:0000071 name: levofloxacin namespace: antibiotic_resistance def: "Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Its main target is topoisomerase IV, inhibiting its function and disrupting DNA replication." [PMID:15700957] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Levaquin" EXACT [] synonym: "Tavanic" EXACT [] xref: pubchem.compound:149096 [Term] id: ARO:0000072 name: linezolid namespace: antibiotic_resistance def: "Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes." [PMID:15700955, PMID:18757750] is_a: ARO:3000079 ! oxazolidinone antibiotic synonym: "Zyvox" EXACT [] synonym: "Zyvoxa" EXACT [] synonym: "Zyvoxam" EXACT [] synonym: "Zyvoxid" EXACT [] xref: pubchem.compound:441401 [Term] id: ARO:0000073 name: meropenem namespace: antibiotic_resistance def: "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem." [PMID:18416587] is_a: ARO:0000020 ! carbapenem synonym: "Meronem" EXACT [] synonym: "Meropen" EXACT [] synonym: "Meropenem anhydrous" EXACT [] synonym: "Meropenemum" EXACT [] synonym: "Merrem" EXACT [] xref: pubchem.compound:441130 [Term] id: ARO:0000074 name: moxifloxacin namespace: antibiotic_resistance def: "Moxifloxacin is a fourth generation synthetic fluoroquinolone chemotherapeutic agent, and has been shown to be significantly more active than levofloxacin (4 to 8 times more) against Streptococcus pneumoniae. It acts by inhibiting bacterial DNA topoisomerases." [PMID:10193688, PMID:11858629] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Actira (hydrochloride)" EXACT [] synonym: "Avelox (hydrochloride)" EXACT [] synonym: "Avelox" EXACT [] synonym: "MXFX" EXACT [] synonym: "Moxifloxacin hydrochloride" EXACT [] synonym: "Vigamox" EXACT [] xref: pubchem.compound:152946 [Term] id: ARO:0000075 name: nitrofurantoin namespace: antibiotic_resistance def: "Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin." [PMID:7928834, PMID:1100114] is_a: ARO:3004116 ! nitrofuran antibiotic synonym: "Chemiofuran" EXACT [] synonym: "Cistofuran" EXACT [] synonym: "Furadantin" EXACT [] synonym: "Furadantine" EXACT [] synonym: "Furalan" EXACT [] synonym: "Macrobid" EXACT [] synonym: "Macrodantin" EXACT [] synonym: "Macrodantina" EXACT [] synonym: "Nitrofuradantin" EXACT [] xref: pubchem.compound:6604200 [Term] id: ARO:0000076 name: resistance-modifying agents namespace: antibiotic_resistance def: "Resistance-modifying agents (RMA) include antibiotic adjuvants and other inhibitors of antibiotic resistance, as well as antibiotic potentiators. These are non-antibiotic compounds which act to block resistance mechanisms or enhance antibiotic action. These are often delivered in combination with an antibiotic (e.g. amoxicillin-clavulanic acid) and may either affect the host organism or the pathogen. Adjuvants and potentiators are therefore used to rescue the activity of existing antibiotic drugs, and are researched as an alternative solution to the antibiotic resistance crisis." [] is_a: ARO:1000001 ! process or component of antibiotic biology or chemistry [Term] id: ARO:0000077 name: tazobactam namespace: antibiotic_resistance def: "Tazobactam is a compound which inhibits the action of bacterial beta-lactamases." [] is_a: ARO:3007130 ! beta-lactam derived beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000873 ! TEM-1 relationship: is_small_molecule_inhibitor ARO:3000874 ! TEM-2 relationship: is_small_molecule_inhibitor ARO:3000875 ! TEM-3 relationship: is_small_molecule_inhibitor ARO:3000877 ! TEM-5 relationship: is_small_molecule_inhibitor ARO:3000878 ! TEM-6 relationship: is_small_molecule_inhibitor ARO:3000879 ! TEM-7 relationship: is_small_molecule_inhibitor ARO:3000881 ! TEM-9 relationship: is_small_molecule_inhibitor ARO:3000882 ! TEM-10 relationship: is_small_molecule_inhibitor ARO:3000884 ! TEM-12 relationship: is_small_molecule_inhibitor ARO:3000896 ! TEM-26 relationship: is_small_molecule_inhibitor ARO:3001059 ! SHV-1 relationship: is_small_molecule_inhibitor ARO:3001060 ! SHV-2 relationship: is_small_molecule_inhibitor ARO:3001062 ! SHV-3 relationship: is_small_molecule_inhibitor ARO:3001064 ! SHV-5 relationship: is_small_molecule_inhibitor ARO:3001397 ! OXA-2 relationship: is_small_molecule_inhibitor ARO:3001864 ! CTX-M-1 relationship: is_small_molecule_inhibitor ARO:3001871 ! CTX-M-8 relationship: is_small_molecule_inhibitor ARO:3001877 ! CTX-M-14 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3001879 ! CTX-M-16 relationship: is_small_molecule_inhibitor ARO:3002065 ! CMY-54 synonym: "Zosyn" EXACT [] xref: pubchem.compound:123630 [Term] id: ARO:0000078 name: piperacillin namespace: antibiotic_resistance def: "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria." [PMID:11735679] is_a: ARO:3000008 ! penam synonym: "Piperacillin anhydrous" EXACT [] synonym: "Piperacillin sodium" EXACT [] synonym: "Pipercillin" EXACT [] synonym: "Pipracil" EXACT [] synonym: "Pipril" EXACT [] xref: pubchem.compound:43672 [Term] id: ARO:0000079 name: clavulanic acid namespace: antibiotic_resistance def: "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins." [] is_a: ARO:3007130 ! beta-lactam derived beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000873 ! TEM-1 relationship: is_small_molecule_inhibitor ARO:3000874 ! TEM-2 relationship: is_small_molecule_inhibitor ARO:3000875 ! TEM-3 relationship: is_small_molecule_inhibitor ARO:3000877 ! TEM-5 relationship: is_small_molecule_inhibitor ARO:3000878 ! TEM-6 relationship: is_small_molecule_inhibitor ARO:3000879 ! TEM-7 relationship: is_small_molecule_inhibitor ARO:3000881 ! TEM-9 relationship: is_small_molecule_inhibitor ARO:3000882 ! TEM-10 relationship: is_small_molecule_inhibitor ARO:3000884 ! TEM-12 relationship: is_small_molecule_inhibitor ARO:3000896 ! TEM-26 relationship: is_small_molecule_inhibitor ARO:3001059 ! SHV-1 relationship: is_small_molecule_inhibitor ARO:3001060 ! SHV-2 relationship: is_small_molecule_inhibitor ARO:3001062 ! SHV-3 relationship: is_small_molecule_inhibitor ARO:3001064 ! SHV-5 relationship: is_small_molecule_inhibitor ARO:3001864 ! CTX-M-1 relationship: is_small_molecule_inhibitor ARO:3001871 ! CTX-M-8 relationship: is_small_molecule_inhibitor ARO:3001877 ! CTX-M-14 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3001879 ! CTX-M-16 synonym: "Acide clavulanique" EXACT [] synonym: "Acido clavulanico" EXACT [] synonym: "Clavulansaeure" EXACT [] synonym: "Clavulox" EXACT [] synonym: "Isoclavulanic acid" EXACT [] synonym: "Sodium Clavulanate" EXACT [] synonym: "acidum clavulanicum" EXACT [] synonym: "clavulanate" EXACT [] xref: pubchem.compound:5280980 [Term] id: ARO:0001001 name: antibiotic target alteration namespace: antibiotic_resistance def: "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance." [] is_a: ARO:1000002 ! mechanism of antibiotic resistance [Term] id: ARO:0001002 name: antibiotic target replacement namespace: antibiotic_resistance def: "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance." [] is_a: ARO:1000002 ! mechanism of antibiotic resistance synonym: "antibiotic target substitution" EXACT [] [Term] id: ARO:0001003 name: antibiotic target protection namespace: antibiotic_resistance def: "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance." [PMID:32587401] is_a: ARO:1000002 ! mechanism of antibiotic resistance [Term] id: ARO:0001004 name: antibiotic inactivation namespace: antibiotic_resistance def: "Enzymatic inactivation of antibiotic to confer drug resistance." [PMID:20564281] is_a: ARO:1000002 ! mechanism of antibiotic resistance synonym: "drug enzymatic inactivation" EXACT [] synonym: "drug enzymatic modification" EXACT [] [Term] id: ARO:0010000 name: antibiotic efflux namespace: antibiotic_resistance def: "Antibiotic resistance via the transport of antibiotics out of the cell." [PMID:19678712] is_a: ARO:1000002 ! mechanism of antibiotic resistance [Term] id: ARO:0010001 name: ATP-binding cassette (ABC) antibiotic efflux pump namespace: antibiotic_resistance def: "Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes." [PMID:8302219] is_a: ARO:3000159 ! efflux pump complex or subunit conferring antibiotic resistance synonym: "ABC type drug efflux" EXACT [] [Term] id: ARO:0010002 name: major facilitator superfamily (MFS) antibiotic efflux pump namespace: antibiotic_resistance def: "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient." [PMID:19678712, PMID:10943556, PMID:9529885] is_a: ARO:3000159 ! efflux pump complex or subunit conferring antibiotic resistance synonym: "MFS type drug efflux" EXACT [] [Term] id: ARO:0010003 name: small multidrug resistance (SMR) antibiotic efflux pump namespace: antibiotic_resistance def: "Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain." [PMID:17942072] is_a: ARO:3000159 ! efflux pump complex or subunit conferring antibiotic resistance synonym: "SMR type drug efflux" EXACT [] [Term] id: ARO:0010004 name: resistance-nodulation-cell division (RND) antibiotic efflux pump namespace: antibiotic_resistance def: "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient." [PMID:15582398, PMID:19664953, PMID:16915237] is_a: ARO:3000159 ! efflux pump complex or subunit conferring antibiotic resistance synonym: "RND type drug efflux" EXACT [] [Term] id: ARO:1000001 name: process or component of antibiotic biology or chemistry namespace: antibiotic_resistance def: "Antibiotic resistance is the ability of a microorganism to withstand the effects of an antibiotic. It is a specific type of drug resistance." [] [Term] id: ARO:1000002 name: mechanism of antibiotic resistance namespace: antibiotic_resistance def: "Antibiotic resistance mechanisms evolve naturally via natural selection through random mutation, but it could also be engineered by applying an evolutionary stress on a population." [] is_a: ARO:1000001 ! process or component of antibiotic biology or chemistry [Term] id: ARO:1000003 name: antibiotic molecule namespace: antibiotic_resistance def: "Antibiotics are commonly classified based on their mechanism of action, chemical structure or spectrum of activity." [] is_a: ARO:1000001 ! process or component of antibiotic biology or chemistry [Term] id: ARO:3000000 name: determinant of antibiotic resistance namespace: antibiotic_resistance def: "A mutation, single nucleotide polymorphism, gene, or gene product that confers antibiotic resistance." [PMID:15700955] is_a: ARO:1000001 ! process or component of antibiotic biology or chemistry [Term] id: ARO:3000001 name: beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases are enzymes (EC 3.5.2.6) produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins (are relatively resistant to beta-lactamase), cephamycins, and carbapenems (ertapenem). These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam. The lactamase enzyme breaks that ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to treat a broad spectrum of gram-positive and gram-negative bacteria. Beta-lactamases produced by gram-negative organisms are usually secreted." [PMID:19995920, PMID:7574506, PMID:21220461, PMID:6109327] is_a: ARO:3000557 ! antibiotic inactivation enzyme [Term] id: ARO:3000002 name: vanW namespace: antibiotic_resistance def: "vanW is an accessory gene, with unknown function, found on vancomycin resistance operons." [PMID:11036060] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000003 name: antibiotic without defined classification namespace: antibiotic_resistance def: "These compounds are antibiotics of unique structure or origin, without a defined classification." [] is_a: ARO:1000003 ! antibiotic molecule synonym: "miscellaneous antibiotic" EXACT [] [Term] id: ARO:3000004 name: class B (metallo-) beta-lactamase namespace: antibiotic_resistance def: "Ambler Class B beta-lactamases are the metallo-beta-lactamases. These enzymes possess one or two zinc ions in the active site, which are used to orient a hydroxide nucleophile to attack the carbonyl on a beta-lactam ring. There are currently no inhibitors in late-stage development for these relatively new beta-lactamases." [PMID:15215079, PMID:14629034] is_a: ARO:3000001 ! beta-lactamase relationship: participates_in ARO:3000203 ! hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase synonym: "Molecular Class B beta-lactamase" EXACT [] [Term] id: ARO:3000005 name: vanD namespace: antibiotic_resistance def: "VanD is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance." [PMID:10368136] is_a: ARO:3002978 ! D-Ala-D-Lac ligase relationship: part_of ARO:3000253 ! glycopeptide resistance gene cluster VanD synonym: "vanD" EXACT CARD_Short_Name [] [Term] id: ARO:3000006 name: vanH namespace: antibiotic_resistance def: "VanH is a D-specific alpha-ketoacid dehydrogenase that synthesizes D-lactate. D-lactate is incorporated into the end of the peptidoglycan subunits, decreasing vancomycin binding affinity." [PMID:9177243, PMID:1931965] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000007 name: beta-lactam antibiotic namespace: antibiotic_resistance def: "Beta-lactam antibiotics are a broad class of antibiotics that include penams (penicillin derivatives), cephems (cephalosporins), monobactams, and carbapenems. These antibiotic agents contain a beta-lactam nucleus in its molecular structure. They are the most widely-used group of antibiotics." [PMID:3889939] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000008 name: penam namespace: antibiotic_resistance def: "Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms." [PMID:3889939] is_a: ARO:3000007 ! beta-lactam antibiotic [Term] id: ARO:3000010 name: vanA namespace: antibiotic_resistance def: "VanA is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with both vancomycin and teicoplanin resistance." [PMID:9177243] is_a: ARO:3002978 ! D-Ala-D-Lac ligase relationship: part_of ARO:3000236 ! glycopeptide resistance gene cluster VanA synonym: "vanA" EXACT CARD_Short_Name [] xref: PDB:1E4E [Term] id: ARO:3000011 name: vanX namespace: antibiotic_resistance def: "VanX is a D,D-dipeptidase that cleaves D-Ala-D-Ala but not D-Ala-D-Lac, ensuring that the latter dipeptide that has reduced binding affinity with vancomycin is used to synthesize peptidoglycan substrate." [PMID:7854121] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000012 name: protein(s) conferring antibiotic resistance via molecular bypass namespace: antibiotic_resistance def: "Proteins involved in restructuring of the cell wall, causing antibiotic resistance." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:3000213 ! restructuring of bacterial cell wall conferring antibiotic resistance [Term] id: ARO:3000013 name: vanB namespace: antibiotic_resistance def: "VanB is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with vancomycin resistance, but not teicoplanin resistance." [PMID:9177243] is_a: ARO:3002978 ! D-Ala-D-Lac ligase relationship: part_of ARO:3000238 ! glycopeptide resistance gene cluster VanB synonym: "vanB" EXACT CARD_Short_Name [] [Term] id: ARO:3000014 name: TEM beta-lactamase namespace: antibiotic_resistance def: "TEM-1 is the most commonly-encountered beta-lactamase in gram-negative bacteria. Up to 90% of ampicillin resistance in E. coli is due to the production of TEM-1. Also responsible for the ampicillin and penicillin resistance that is seen in H. influenzae and N. gonorrhoeae in increasing numbers. Although TEM-type beta-lactamases are most often found in E. coli and K. pneumoniae, they are also found in other species of gram-negative bacteria with increasing frequency. The amino acid substitutions responsible for the ESBL phenotype cluster around the active site of the enzyme and change its configuration, allowing access to oxyimino-beta-lactam substrates. Opening the active site to beta-lactam substrates also typically enhances the susceptibility of the enzyme to b-lactamase inhibitors, such as clavulanic acid. Although the inhibitor-resistant beta-lactamases are not ESBLs, they are often discussed with ESBLs because they are also derivatives of the classical TEM- or SHV-type enzymes. These enzymes were at first given the designation IRT for inhibitor-resistant TEM beta-lactamase; however, all have subsequently been renamed with numerical TEM designations. There are at least 19 distinct inhibitor-resistant TEM beta-lactamases. Inhibitor-resistant TEM beta-lactamases have been found mainly in clinical isolates of E. coli, but also some strains of K. pneumoniae, Klebsiella oxytoca, P. mirabilis, and Citrobacter freundii. Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam-lactamase inhibitor combinations of amoxicillin-clavulanate (Co-amoxiclav), ticarcillin-clavulanate, and ampicillin/sulbactam, they normally remain susceptible to inhibition by tazobactam and subsequently the combination of piperacillin/tazobactam, although resistance has been described." [PMID:11585791, PMID:8432315] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3000015 name: SHV beta-lactamase namespace: antibiotic_resistance def: "SHV-1 shares 68 percent of its amino acids with TEM-1 and has a similar overall structure. The SHV-1 beta-lactamase is most commonly found in K. pneumoniae and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. ESBLs in this family also have amino acid changes around the active site, most commonly at positions 238 or 238 and 240. More than 60 SHV varieties are known." [PMID:11585791] is_a: ARO:3000096 ! SHV-LEN beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000016 name: CTX-M beta-lactamase namespace: antibiotic_resistance def: "These enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (eg, ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition of beta-lactamase genes normally found on the chromosome of Kluyvera species, a group of rarely pathogenic commensal organisms. These enzymes are not very closely related to TEM or SHV beta-lactamases in that they show only approximately 40% identity with these two commonly isolated beta-lactamases. Despite their name, a few are more active on ceftazidime than cefotaxime. CTX-M-15 was recently found in bacterial strains expressing NDM-1 and were responsible for resistance to aztreonam." [PMID:20705517] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3000017 name: OXA beta-lactamase namespace: antibiotic_resistance def: "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime." [PMID:16891520, PMID:24696435] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000056 ! oxacillin [Term] id: ARO:3000018 name: IMI beta-lactamase namespace: antibiotic_resistance def: "IMI beta-lactamases are a group of TEM-1-like beta-lactamase that are known to hydrolyze imipenem. IMI beta-lactamases are inhibited by clavulanic acid and tazobactam." [PMID:8878585] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3000020 name: IMP beta-lactamase namespace: antibiotic_resistance def: "Plasmid mediated IMP-type carbapenemases, of which at least 26 varieties are currently known, became established in Japan in the 1990s in enteric gram-negative organisms, Pseudomonas and Acinetobacter species. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors." [PMID:8141584, PMID:20121112] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3000021 name: VIM beta-lactamase namespace: antibiotic_resistance def: "The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants. VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. There is a strong incidence of these in East Asia." [PMID:12562689, PMID:18061205, PMID:20121112] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3000022 name: ristocetin namespace: antibiotic_resistance def: "Ristocetin is a glycopeptide antibiotic similar to vancomycin but positively charged. It is not used clinically because it induces platelet agglutination." [PMID:2532132, PMID:17620] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:16204749 [Term] id: ARO:3000023 name: aminocoumarin sensitive parE namespace: antibiotic_resistance def: "Subunit of the topoisomerase IV sensitive to aminocoumarins." [PMID:16127057, PMID:12604514] is_a: ARO:3003259 ! antibiotic sensitive DNA topoisomerase subunit parE relationship: targeted_by ARO:3000103 ! aminocoumarin antibiotic relationship: targeted_by_antibiotic ARO:3000111 ! novobiocin relationship: targeted_by_antibiotic ARO:3000132 ! clorobiocin relationship: targeted_by_antibiotic ARO:3000150 ! coumermycin A1 [Term] id: ARO:3000024 name: patA namespace: antibiotic_resistance def: "PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance." [PMID:20709735, PMID:20937787] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000769 ! PatA-PatB synonym: "patA" EXACT CARD_Short_Name [] [Term] id: ARO:3000025 name: patB namespace: antibiotic_resistance def: "PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance.." [PMID:20937787, PMID:20709735] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000769 ! PatA-PatB synonym: "patB" EXACT CARD_Short_Name [] [Term] id: ARO:3000026 name: mepA namespace: antibiotic_resistance def: "MepA is an efflux protein regulated by MepR and part of the MepRAB cluster. Its presence in Staphylococcus aureus led to multidrug resistance, while it has also been shown to decrease tigecycline susceptibility." [PMID:15855507, PMID:16569840, PMID:15855508] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline relationship: confers_resistance_to_drug_class ARO:0000042 ! glycylcycline synonym: "mepA" EXACT CARD_Short_Name [] [Term] id: ARO:3000027 name: emrA namespace: antibiotic_resistance def: "EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium." [PMID:7730261] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000344 ! EmrAB-TolC synonym: "emrA" EXACT CARD_Short_Name [] [Term] id: ARO:3000034 name: nucleoside antibiotic namespace: antibiotic_resistance def: "Nucleoside antibiotics are made of modified nucleosides and nucleotides with wide-ranging activities and means of antibacterial effects. This drug class includes aminonucleoside antibiotics, which contain an amino group." [PMID:3061990, PMID:18679046] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000035 name: lipopeptide antibiotic namespace: antibiotic_resistance def: "Lipopeptide antibiotics are aliphatic, with their hydrophobic components interacting with the bacterial cell membrane." [PMID:19156787] is_a: ARO:3000053 ! peptide antibiotic [Term] id: ARO:3000036 name: tetracycline inactivation enzyme namespace: antibiotic_resistance def: "Enzymes or other gene products which hydroxylate tetracycline and other tetracycline derivatives. Hydroxylation inactivates tetracycline-like antibiotics, thus conferring resistance to these compounds." [PMID:24497223] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000050 ! tetracycline antibiotic relationship: participates_in ARO:3000450 ! hydroxylation of antibiotic conferring resistance [Term] id: ARO:3000040 name: hydrolysis of antibiotic conferring resistance namespace: antibiotic_resistance def: "Hydrolysis of an antibiotic molecule to confer resistance." [] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000042 name: beta-lactamase inhibitor namespace: antibiotic_resistance def: "Antibiotic adjuvants shown to inhibit the action of a beta-lactamase enzyme or enhance the ability of a beta-lactam antibiotic. These compounds are used along with antibiotics to treat beta-lactam-resistant infectious pathogens." [] is_a: ARO:3007222 ! inhibitor of antibiotic resistance mechanism [Term] id: ARO:3000043 name: VEB beta-lactamase namespace: antibiotic_resistance def: "VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam." [PMID:10049269] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3000045 name: component of AMR genotypic or phenotypic terminology namespace: antibiotic_resistance def: "A collection of curated phenotypic terms relating to antibiotic resistance and the Comprehensive Antibiotic Resistance Database." [] is_a: ARO:1000001 ! process or component of antibiotic biology or chemistry [Term] id: ARO:3000050 name: tetracycline antibiotic namespace: antibiotic_resistance def: "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes." [PMID:11381101] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000053 name: peptide antibiotic namespace: antibiotic_resistance def: "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics." [PMID:18065456, PMID:10348745] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000055 name: SME beta-lactamase namespace: antibiotic_resistance def: "SME beta-lactamases are chromosome-mediated class A beta-lactamases that hydrolyze carbapenems in Serratia marcescens." [PMID:8092824] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3000056 name: PER beta-lactamase namespace: antibiotic_resistance def: "PER beta-lactamases are plasmid-mediated extended spectrum beta-lactamases found in the Enterobacteriaceae family." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3000057 name: NDM beta-lactamase namespace: antibiotic_resistance def: "NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins." [PMID:22078325, PMID:21624908, PMID:24165671, PMID:19770275, PMID:21507902, PMID:21393184, PMID:21930874, PMID:20705517] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000058 name: MIR beta-lactamase namespace: antibiotic_resistance def: "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams." [PMID:1963529] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3000059 name: KPC beta-lactamase namespace: antibiotic_resistance def: "Klebsiella pneumoniae carbapenem resistant (KPC) beta-lactamases are notorious for their ability to efficiently hydrolyze carbapenems, unlike other Ambler Class A beta-lactamases. There are currently 9 variants reported worldwide. These enzymes were first isolated from Klebsiella pneumoniae strains in 2001 in the United States. Hospital outbreaks have since been reported in Greece and Israel and KPC carrying strains are now endemic to New York facilities. KPC-1 and KPC-2 have been shown to be identical and are now referred to as KPC-2." [PMID:19493866, PMID:17441734] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000060 name: IND beta-lactamase namespace: antibiotic_resistance def: "IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases." [PMID:10077836] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3000066 name: GES beta-lactamase namespace: antibiotic_resistance def: "GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000067 name: FOX beta-lactamase namespace: antibiotic_resistance def: "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins." [PMID:7811034] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin [Term] id: ARO:3000068 name: DHA beta-lactamase namespace: antibiotic_resistance def: "DHA beta-lactamases are plasmid-mediated AmpC β-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins." [PMID:9736562] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin [Term] id: ARO:3000069 name: CMY beta-lactamase namespace: antibiotic_resistance def: "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins." [] is_a: ARO:3000086 ! CMY-LAT beta-lactamase is_a: ARO:3000087 ! CMY-MOX beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin [Term] id: ARO:3000071 name: vanS namespace: antibiotic_resistance def: "VanS is similar to histidine protein kinases like EnvZ and acts as a response regulator by activating VanR. VanS is required for high level transcription of other van glycopeptide resistance genes." [PMID:1556077] is_a: ARO:3002905 ! VanS-VanR two-component regulatory system relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000072 name: ACT beta-lactamase namespace: antibiotic_resistance def: "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae." [PMID:9055993] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000073 name: ACC beta-lactamase namespace: antibiotic_resistance def: "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins." [PMID:10428914] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000074 name: emrB namespace: antibiotic_resistance def: "emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin." [PMID:1409590] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000344 ! EmrAB-TolC synonym: "emrB" EXACT CARD_Short_Name [] [Term] id: ARO:3000075 name: class D beta-lactamase namespace: antibiotic_resistance def: "Class D beta-lactamases are one of the subgroups of beta-lactamases that are classified as serine enzymes." [] is_a: ARO:3000001 ! beta-lactamase relationship: participates_in ARO:3000187 ! hydrolysis of beta-lactam antibiotic by serine beta-lactamase [Term] id: ARO:3000076 name: class C beta-lactamase namespace: antibiotic_resistance def: "AmpC type beta-lactamases are commonly isolated from extended-spectrum cephalosporin-resistant Gram-negative bacteria. AmpC beta-lactamases (also termed class C or group 1) are typically encoded on the chromosome of many Gram-negative bacteria including Citrobacter, Serratia, Enterobacter species, and P. aeruginosa where its expression is usually inducible; it may also occur on Escherichia coli but is not usually inducible, although it can be hyperexpressed. AmpC type beta-lactamases may also be carried on plasmids. AmpC beta-lactamases, in contrast to ESBLs, hydrolyse broad and extended-spectrum cephalosporins (cephamycins as well as to oxyimino-beta-lactams) but are not inhibited by beta-lactamase inhibitors such as clavulanic acid." [PMID:19822890] is_a: ARO:3000001 ! beta-lactamase relationship: participates_in ARO:3000187 ! hydrolysis of beta-lactam antibiotic by serine beta-lactamase synonym: "AmpC beta-lactamase" EXACT [] [Term] id: ARO:3000077 name: vanY namespace: antibiotic_resistance def: "VanY is a D,D-carboxypeptidase that cleaves removes the terminal D-Ala from peptidoglycan for the addition of D-Lactate. The D-Ala-D-Lac peptidoglycan subunits have reduced binding affinity with vancomycin compared to D-Ala-D-Ala." [PMID:16323116, PMID:24711382] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000078 name: class A beta-lactamase namespace: antibiotic_resistance def: "The Class A beta-lactamases are one of the subgroups of beta-lactamases that are classified as serine enzymes. Class A beta-lactamases exhibit a large degree of variability and are known to hydrolyze penicillins." [PMID:17407578] is_a: ARO:3000001 ! beta-lactamase relationship: participates_in ARO:3000187 ! hydrolysis of beta-lactam antibiotic by serine beta-lactamase [Term] id: ARO:3000079 name: oxazolidinone antibiotic namespace: antibiotic_resistance def: "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use." [PMID:18757750] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000080 name: aminonucleoside antibiotic namespace: antibiotic_resistance def: "Aminonucleoside antibiotics are nucleoside antibiotics that contain an amino group. This amino group is often acylated, e.g. puromycin." [PMID:8576156] is_a: ARO:3000034 ! nucleoside antibiotic [Term] id: ARO:3000081 name: glycopeptide antibiotic namespace: antibiotic_resistance def: "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria. This inhibits transglycosylation leading to cell death due to osmotic stress." [PMID:4369274, PMID:3276316, PMID:16007453, PMID:10232990] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000082 name: antibiotic biosynthesis namespace: antibiotic_resistance def: "The biological synthesis of antibiotics." [] is_a: ARO:1000001 ! process or component of antibiotic biology or chemistry [Term] id: ARO:3000083 name: MOX beta-lactamase namespace: antibiotic_resistance def: "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases." [] is_a: ARO:3000087 ! CMY-MOX beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000085 name: CMY-LAT-MOX beta-lactamase namespace: antibiotic_resistance def: "A grouping of the related CMY, LAT, and MOX beta-lactamases." [] is_a: ARO:3000076 ! class C beta-lactamase [Term] id: ARO:3000086 name: CMY-LAT beta-lactamase namespace: antibiotic_resistance def: "A grouping of the related CMY and LAT beta-lactamases." [] is_a: ARO:3000085 ! CMY-LAT-MOX beta-lactamase [Term] id: ARO:3000087 name: CMY-MOX beta-lactamase namespace: antibiotic_resistance def: "A grouping of the related CMY and MOX beta-lactamases." [] is_a: ARO:3000085 ! CMY-LAT-MOX beta-lactamase [Term] id: ARO:3000089 name: AER beta-lactamase namespace: antibiotic_resistance def: "AER beta-lactamases are capable of hydrolyzing arbenicillin." [PMID:9687391] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam synonym: "AsbB1" EXACT [] [Term] id: ARO:3000090 name: Bla1 namespace: antibiotic_resistance def: "Bla1 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which hydrolyzes penicillins." [PMID:12760895, PMID:27557855] is_a: ARO:3004229 ! class A Bacillus anthracis Bla beta-lactamase synonym: "Bla1" EXACT CARD_Short_Name [] [Term] id: ARO:3000091 name: CARB beta-lactamase namespace: antibiotic_resistance def: "CARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10." [PMID:9687391, PMID:6782068] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000094 name: OCH beta-lactamase namespace: antibiotic_resistance def: "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi." [PMID:11451692] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3000095 name: SRT beta-lactamase namespace: antibiotic_resistance def: "SRT beta-lactamases." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3000096 name: SHV-LEN beta-lactamase namespace: antibiotic_resistance def: "A grouping of the related SHV and LEN beta-lactamases." [] is_a: ARO:3000078 ! class A beta-lactamase [Term] id: ARO:3000097 name: LEN beta-lactamase namespace: antibiotic_resistance def: "LEN beta-lactamases are chromosomal class A beta-lactamases that confer resistance to ampicillin, amoxicillin, carbenicillin, and ticarcillin but not to extended-spectrum beta-lactams." [PMID:15215087] is_a: ARO:3000096 ! SHV-LEN beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3000098 name: PDC beta-lactamase namespace: antibiotic_resistance def: "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3000100 name: gene modulating beta-lactam resistance namespace: antibiotic_resistance def: "Genes that directly or indirectly modulate beta-lactam resistance." [PMID:16143832] is_a: ARO:3000000 ! determinant of antibiotic resistance [Term] id: ARO:3000103 name: aminocoumarin antibiotic namespace: antibiotic_resistance def: "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling." [PMID:8231802] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000105 name: phosphorylation of antibiotic conferring resistance namespace: antibiotic_resistance def: "Phosphorylation of antibiotic usually by ATP, sometimes GTP." [] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000106 name: acylation of antibiotic conferring resistance namespace: antibiotic_resistance def: "Addition of an acyl group to an antibiotic, often via acetylation by acetylCoA." [] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000107 name: nucleotidylation of antibiotic conferring resistance namespace: antibiotic_resistance def: "Modification by NMP, usually AMP." [] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000111 name: novobiocin namespace: antibiotic_resistance def: "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling." [PMID:8231802, PMID:10770754, PMID:4680802] is_a: ARO:3000103 ! aminocoumarin antibiotic synonym: "cathomycin" EXACT [] synonym: "streptonivicin" EXACT [] xref: pubchem.compound:54675769 [Term] id: ARO:3000112 name: multidrug and toxic compound extrusion (MATE) transporter namespace: antibiotic_resistance def: "Directed pumping of antibiotic out of a cell to confer resistance. Multidrug and toxic compound extrusion (MATE) transporters utilize the cationic gradient across the membrane as an energy source. Although there is a diverse substrate specificity, almost all MATE transporters recognize fluoroquinolones. Arciflavine, ethidium and aminoglycosides are also good substrates." [PMID:16330770, PMID:19100867] is_a: ARO:3000159 ! efflux pump complex or subunit conferring antibiotic resistance [Term] id: ARO:3000113 name: vga-type ABC-F protein namespace: antibiotic_resistance def: "Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection." [PMID:15728891, PMID:20876620, PMID:21768510] is_a: ARO:3004469 ! ABC-F ATP-binding cassette ribosomal protection protein relationship: confers_resistance_to_drug_class ARO:0000034 ! streptogramin A antibiotic relationship: confers_resistance_to_drug_class ARO:3000670 ! pleuromutilin antibiotic [Term] id: ARO:3000114 name: aminoglycoside phosphotransferase (APH) namespace: antibiotic_resistance def: "Kinases that modify aminoglycoside antibiotics by phosphorylation using NTPs as cofactor." [PMID:9872733, PMID:20833577] is_a: ARO:3007380 ! aminoglycoside modifying enzyme relationship: participates_in ARO:3000105 ! phosphorylation of antibiotic conferring resistance synonym: "aminoglycoside kinase" EXACT [] [Term] id: ARO:3000115 name: antibiotic resistant DNA topoisomerase subunit parE namespace: antibiotic_resistance def: "ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Mutations in ParE prevents antibiotics from inhibiting DNA synthesis, thus conferring resistance." [] is_a: ARO:3000370 ! antibiotic resistant DNA topoisomerase subunit relationship: derives_from ARO:3003259 ! antibiotic sensitive DNA topoisomerase subunit parE [Term] id: ARO:3000116 name: vanZ namespace: antibiotic_resistance def: "VanZ is a teicoplanin resistance gene that is an accessory protein. VanZ prevents the incorporation of the terminal D-Ala into peptidoglycan subunits." [PMID:16323116] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000117 name: antibiotic A47934 namespace: antibiotic_resistance def: "A47934 is an 'aglycone' glycopeptide antibiotic produced by Streptomyces toyocaensis. It is a teicoplanin-like glycopeptide." [PMID:9435111, PMID:12060705, PMID:17884639, PMID:16492565] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:16131155 [Term] id: ARO:3000118 name: vgaB namespace: antibiotic_resistance def: "Vga(B) is an ABC-F protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA." [PMID:15728891, PMID:9427556] is_a: ARO:3000113 ! vga-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin synonym: "vgaB" EXACT CARD_Short_Name [] [Term] id: ARO:3000119 name: edeine namespace: antibiotic_resistance def: "Edeines are basic linear peptides produced by Bacillus brevis Vm4. They have antibacterial as well as antifungal, antiviral, and anticancer properties. Edeines are bacteriostatic and bacteriocidal at low and high concentrations, respectively. They are able to inhibit DNA synthesis and protein translation. These compounds are synthesized by nonribosomal peptide synthetases and contain numerous unusual amino acids." [PMID:70202] is_a: ARO:3000053 ! peptide antibiotic [Term] id: ARO:3000120 name: balhimycin namespace: antibiotic_resistance def: "Balhimycin is a vancomycin-like glycopeptide antibiotic produced by Amycolatopsis balhimycina. It binds to the terminal Lys-D-Ala-D-Ala of peptidoglycan precursors." [PMID:11932455, PMID:16730832, PMID:10390204, PMID:11495926, PMID:9761883] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:16134543 [Term] id: ARO:3000121 name: aminoglycoside acetyltransferase (AAC) namespace: antibiotic_resistance def: "Aminoglycoside acetyltransferase enzymes modify aminoglycoside antibiotics by catalyzing the transfer of an acetyl group to one of the amino groups present in aminoglycosides, using acetyl coenzyme A as a donor substrate." [PMID:20833577] is_a: ARO:3007380 ! aminoglycoside modifying enzyme relationship: participates_in ARO:3000106 ! acylation of antibiotic conferring resistance synonym: "aminoglycoside N-acetyltransferase" EXACT [] [Term] id: ARO:3000122 name: chloramphenicol acetyltransferase (CAT) namespace: antibiotic_resistance def: "Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini." [PMID:3865770, PMID:1650008, PMID:1461942, PMID:1713259, PMID:2227449, PMID:19459958, PMID:2993795, PMID:11735367, PMID:1406372, PMID:11743194, PMID:3860383, PMID:3110008, PMID:3900035, PMID:1929282, PMID:11677608, PMID:2697637, PMID:12650243, PMID:12732947, PMID:12726767, PMID:12603745, PMID:9349809, PMID:6950931, PMID:11553538, PMID:1929326, PMID:15539072, PMID:1517170, PMID:2013403] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000387 ! phenicol antibiotic relationship: participates_in ARO:3000106 ! acylation of antibiotic conferring resistance [Term] id: ARO:3000123 name: gramicidin namespace: antibiotic_resistance def: "Gramicidins are a family of antibiotics synthesized by Bacillus brevis. It includes the linear pentadecapeptides gramicidin A, B and C that make up the mixture gramicidin D. Gramicidin S is a cyclic peptide chain. Gramicidins are also components of tyrothricins, another mixture of antibiotics produced by Bacillus brevis." [] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:16130140 [Term] id: ARO:3000124 name: mecI namespace: antibiotic_resistance def: "mecI acts as a repressor of transcription of the mecA/mecR1/mecI operon." [PMID:24564530] is_a: ARO:3000100 ! gene modulating beta-lactam resistance relationship: part_of ARO:3000268 ! mec operon relationship: regulates ARO:3000617 ! mecA relationship: regulates ARO:3001209 ! mecC synonym: "mecI" EXACT CARD_Short_Name [] [Term] id: ARO:3000125 name: hydrolysis of fosfomycin epoxide ring namespace: antibiotic_resistance def: "The use of different nucleophilic molecules by enzymes can break up the epoxide ring of fosfomycin and render the molecule ineffective." [] is_a: ARO:3000040 ! hydrolysis of antibiotic conferring resistance [Term] id: ARO:3000126 name: APH(3') namespace: antibiotic_resistance def: "A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound." [PMID:9200607, PMID:8385262] is_a: ARO:3000114 ! aminoglycoside phosphotransferase (APH) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000127 name: APH(3'') namespace: antibiotic_resistance def: "A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 3''-hydroxyl group of the compound." [] is_a: ARO:3000114 ! aminoglycoside phosphotransferase (APH) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000128 name: APH(2'') namespace: antibiotic_resistance def: "A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound." [] is_a: ARO:3000114 ! aminoglycoside phosphotransferase (APH) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000130 name: edeine A namespace: antibiotic_resistance def: "Edeine A is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and spermidine. Edeine A is a mixture of edeine A1 and its inactive isomer, edeine A2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication." [PMID:4984939, PMID:70202, PMID:14731399] is_a: ARO:3000053 ! peptide antibiotic is_a: ARO:3000119 ! edeine xref: pubchem.compound:379085 [Term] id: ARO:3000132 name: clorobiocin namespace: antibiotic_resistance def: "Clorobiocin is an aminocoumarin antibiotic produced by Streptomyces roseochromogenes, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling." [PMID:6154685, PMID:12044152, PMID:8231802] is_a: ARO:3000103 ! aminocoumarin antibiotic xref: pubchem.compound:54706138 [Term] id: ARO:3000133 name: fosfomycin thiol transferase namespace: antibiotic_resistance def: "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin." [] is_a: ARO:3000342 ! fosfomycin inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3007149 ! phosphonic acid antibiotic relationship: participates_in ARO:3000125 ! hydrolysis of fosfomycin epoxide ring [Term] id: ARO:3000134 name: edeine B namespace: antibiotic_resistance def: "Edeine B is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and guanylspermidine. Edeine B is a mixture of edeine B1 and its inactive isomer, edeine B2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. Edeine B has also been shown to inhibit septation and cause filamentous morphology, also leading to cell death." [PMID:70202, PMID:4984939, PMID:20410587] is_a: ARO:3000053 ! peptide antibiotic is_a: ARO:3000119 ! edeine xref: pubchem.compound:446232 [Term] id: ARO:3000135 name: edeine D namespace: antibiotic_resistance def: "Edeine D is a subtype of edeine similar to edeine A with the beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication." [PMID:70202] is_a: ARO:3000053 ! peptide antibiotic is_a: ARO:3000119 ! edeine xref: pubchem.compound:170400 [Term] id: ARO:3000136 name: edeine F namespace: antibiotic_resistance def: "Edeine F is a subtype of edeine similar to edeine B with beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication." [PMID:6615592] is_a: ARO:3000053 ! peptide antibiotic is_a: ARO:3000119 ! edeine xref: pubchem.compound:194407 [Term] id: ARO:3000145 name: tylosin namespace: antibiotic_resistance def: "Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis." [PMID:19793461] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5280440 [Term] id: ARO:3000149 name: FosA namespace: antibiotic_resistance def: "An enzyme that confers resistance to fosfomycin in Serratia marcescens by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. In Pseudomonas aeruginosa, FosA catalyzes the conjugation of glutathione to carbon-1 of fosfomycin, rendering it ineffective as an antibacterial drug." [PMID:15075406, PMID:15741169] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosA" EXACT CARD_Short_Name [] xref: PDB:1NPB [Term] id: ARO:3000150 name: coumermycin A1 namespace: antibiotic_resistance def: "Coumermycin A1 is an antibiotic produced by Streptomyces rishiriensis, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling." [PMID:14285469, PMID:11036020, PMID:8231802, PMID:14285468] is_a: ARO:3000103 ! aminocoumarin antibiotic synonym: "Notomycin A1" EXACT [] xref: pubchem.compound:54675768 [Term] id: ARO:3000151 name: APH(6) namespace: antibiotic_resistance def: "A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 6-hydroxyl group of the compound." [] is_a: ARO:3000114 ! aminoglycoside phosphotransferase (APH) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000152 name: minocycline namespace: antibiotic_resistance def: "Minocycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome." [PMID:11381101, PMID:19862477] is_a: ARO:3000050 ! tetracycline antibiotic xref: pubchem.compound:54675783 [Term] id: ARO:3000153 name: APH(9) namespace: antibiotic_resistance def: "A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of spectinomycin, by the ATP-dependent phosphorylation of the 9-hydroxyl group of the compound." [PMID:20089863, PMID:9614079] is_a: ARO:3000114 ! aminoglycoside phosphotransferase (APH) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000154 name: APH(7'') namespace: antibiotic_resistance def: "A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 7''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 7''-hydroxyl group of the compound." [] is_a: ARO:3000114 ! aminoglycoside phosphotransferase (APH) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000155 name: APH(4) namespace: antibiotic_resistance def: "A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 4-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 4-hydroxyl group of the compound." [PMID:21084294] is_a: ARO:3000114 ! aminoglycoside phosphotransferase (APH) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000156 name: spiramycin namespace: antibiotic_resistance def: "Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis." [PMID:7683018] is_a: ARO:0000000 ! macrolide antibiotic synonym: "rovamycin" EXACT [] xref: pubchem.compound:6419898 [Term] id: ARO:3000157 name: rifamycin antibiotic namespace: antibiotic_resistance def: "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs." [PMID:15700959] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000158 name: azithromycin namespace: antibiotic_resistance def: "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation." [PMID:1662624] is_a: ARO:0000000 ! macrolide antibiotic synonym: "AZM" EXACT [] xref: pubchem.compound:447043 [Term] id: ARO:3000159 name: efflux pump complex or subunit conferring antibiotic resistance namespace: antibiotic_resistance def: "Efflux proteins that pump antibiotic out of a cell to confer resistance." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:0010000 ! antibiotic efflux [Term] id: ARO:3000160 name: blaI namespace: antibiotic_resistance def: "blaI acts as a repressor of transcription of the blaZ/blaR1/blaI operon." [PMID:12654668] is_a: ARO:3000100 ! gene modulating beta-lactam resistance relationship: part_of ARO:3000262 ! bla operon relationship: regulates ARO:3000621 ! PC1 beta-lactamase (blaZ) synonym: "blaI" EXACT CARD_Short_Name [] [Term] id: ARO:3000164 name: rRNA methyltransferase conferring antibiotic resistance namespace: antibiotic_resistance def: "Catalyzes methylation of rRNA." [PMID:1929280] is_a: ARO:3000519 ! antibiotic target modifying enzyme relationship: participates_in ARO:3000211 ! ribosomal alteration conferring antibiotic resistance [Term] id: ARO:3000165 name: tet(A) namespace: antibiotic_resistance def: "TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria." [PMID:8821947, PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(A)" EXACT CARD_Short_Name [] synonym: "tetA" EXACT [] [Term] id: ARO:3000166 name: tet(B) namespace: antibiotic_resistance def: "Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline." [PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(B)" EXACT CARD_Short_Name [] synonym: "tetB" EXACT [] [Term] id: ARO:3000167 name: tet(C) namespace: antibiotic_resistance def: "Tet(C) is a tetracycline efflux pump found in many species of Gram-negative bacteria. It is typically found in plasmid DNA." [PMID:6307828] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(C)" EXACT CARD_Short_Name [] synonym: "tetC" EXACT [] [Term] id: ARO:3000168 name: tet(D) namespace: antibiotic_resistance def: "TetD is a tetracycline efflux pump found exclusively in Gram-negative bacteria." [PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(D)" EXACT CARD_Short_Name [] synonym: "tetD" EXACT [] [Term] id: ARO:3000169 name: rifampin namespace: antibiotic_resistance def: "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections." [PMID:6356275, PMID:15667909] is_a: ARO:3000157 ! rifamycin antibiotic synonym: "rifampicin" EXACT [] xref: pubchem.compound:135398735 [Term] id: ARO:3000170 name: imipenem namespace: antibiotic_resistance def: "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes." [PMID:12084099, PMID:10629005] is_a: ARO:0000020 ! carbapenem xref: pubchem.compound:104838 [Term] id: ARO:3000171 name: diaminopyrimidine antibiotic namespace: antibiotic_resistance def: "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups. They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis." [PMID:8195830] is_a: ARO:1000003 ! antibiotic molecule synonym: "diaminopyrimidine" EXACT [] [Term] id: ARO:3000172 name: FosB namespace: antibiotic_resistance def: "A thiol transferase that leads to the resistance of fosfomycin. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol or L-cysteine to open up the epoxide ring of fosfomycin." [PMID:24004181, PMID:24447055] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosB" EXACT CARD_Short_Name [] xref: PDB:4JH1 [Term] id: ARO:3000173 name: tet(E) namespace: antibiotic_resistance def: "TetE is a tetracycline efflux pump found in many Gram-negative bacteria, especially those in water environments. The gene is found on large plasmids." [PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(E)" EXACT CARD_Short_Name [] synonym: "tetE" EXACT [] [Term] id: ARO:3000174 name: tet(G) namespace: antibiotic_resistance def: "TetG is a tetracycline efflux protein found in Gram-negative bacteria. The encoding gene is found in both chromosomal and plasmid DNA where it is frequently linked to the floR, sul1, and cmlA9 genes which encode proteins that can confer florfenicol/chloramphenicol, sulfamethoxazole, and chloramphenicol resistance, respectively." [PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(G)" EXACT CARD_Short_Name [] synonym: "tetG" EXACT [] [Term] id: ARO:3000175 name: tet(H) namespace: antibiotic_resistance def: "TetH is a tetracycline efflux protein expressed in Gram-negative bacteria (Actinobacillus, Acinetobacter, Gallibacterium, Histophilus, Mannheimia, Moraxella, Pasteurella, and Psychrobacter). Its gene is linked to the resistance genes sul2, and strAB, which confer resistance to sulfamethoxazole and streptomycin, respectively." [PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(H)" EXACT CARD_Short_Name [] synonym: "tetH" EXACT [] [Term] id: ARO:3000176 name: dirithromycin namespace: antibiotic_resistance def: "Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis." [PMID:7683018] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:6473883 [Term] id: ARO:3000177 name: tet(J) namespace: antibiotic_resistance def: "TetJ is a tetracycline efflux protein expressed in Gram-negative bacteria (Escherichia, Morganella, and Proteus)." [PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(J)" EXACT CARD_Short_Name [] synonym: "tetJ" EXACT [] [Term] id: ARO:3000178 name: tet(K) namespace: antibiotic_resistance def: "TetK is a tetracycline efflux protein found in both Gram-negative (Haemophilus and Gallibacterium) and Gram-positive (many species, including mycobacteria) bacteria." [PMID:8234490, PMID:7781778, PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(K)" EXACT CARD_Short_Name [] synonym: "tetK" EXACT [] [Term] id: ARO:3000179 name: tet(L) namespace: antibiotic_resistance def: "TetL is a tetracycline efflux protein found in many species of Gram-negative and Gram-positive bacteria." [PMID:3324958, PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(L)" EXACT CARD_Short_Name [] synonym: "tetL" EXACT [] [Term] id: ARO:3000180 name: tetA(P) namespace: antibiotic_resistance def: "TetA(P) is a inner membrane tetracycline efflux protein found on the same operon as the ribosomal protection protein TetB(P). It is found in Clostridium, a Gram-positive bacterium." [PMID:15837373, PMID:14702405] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tetA(P)" EXACT CARD_Short_Name [] synonym: "tetP" EXACT [] [Term] id: ARO:3000181 name: tet(V) namespace: antibiotic_resistance def: "TetV is a tetracycline efflux protein that has been found in Mycolicibacterium smegmatis and Mycolicibacterium fortuitum." [PMID:22673307, PMID:9687386, PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(V)" EXACT CARD_Short_Name [] synonym: "tetV" EXACT [] [Term] id: ARO:3000182 name: tet(Y) namespace: antibiotic_resistance def: "TetY is a tetracycline efflux pump found in Gram-negative bacteria (Aeromonas and Escherichia). It is associated with plasmid DNA." [PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(Y)" EXACT CARD_Short_Name [] synonym: "tetY" EXACT [] [Term] id: ARO:3000183 name: tet(Z) namespace: antibiotic_resistance def: "TetZ is a tetracycline efflux protein found in Gram-positive bacteria (Corynebacterium and Lactobacillus). It is associated with plasmid DNA." [PMID:15837373] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(Z)" EXACT CARD_Short_Name [] synonym: "tetZ" EXACT [] [Term] id: ARO:3000184 name: chloroeremomycin namespace: antibiotic_resistance def: "Chloroeremomycin is a vancomycin-like glycopeptide, with three sugars instead of two in vancomycin and balhimycin. Chloroeremomycin dimerizes and binds to the terminus of peptidoglycan precursors." [PMID:9545426, PMID:11942828, PMID:11035791] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:445806 [Term] id: ARO:3000185 name: antibiotic target protection protein namespace: antibiotic_resistance def: "These proteins confer antibiotic resistance by bind the antibiotic target to prevent antibiotic binding." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:0001003 ! antibiotic target protection [Term] id: ARO:3000186 name: tet(M) namespace: antibiotic_resistance def: "Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented." [PMID:19475445] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(M)" EXACT CARD_Short_Name [] synonym: "tetM" EXACT [] [Term] id: ARO:3000187 name: hydrolysis of beta-lactam antibiotic by serine beta-lactamase namespace: antibiotic_resistance def: "Mechanism of enzymatic degradation common to Ambler Class A, C and D beta-lactamases. A serine residue located in the active site is used to form an acyl-enzyme intermediate and subsequent hydrolysis renders the beta-lactam inactive." [] is_a: ARO:3000040 ! hydrolysis of antibiotic conferring resistance [Term] id: ARO:3000188 name: trimethoprim namespace: antibiotic_resistance def: "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic." [PMID:18024520, PMID:11432417] is_a: ARO:3000171 ! diaminopyrimidine antibiotic xref: pubchem.compound:5578 [Term] id: ARO:3000189 name: oritavancin namespace: antibiotic_resistance def: "Oritavancin is a semi-synthetic derivative of chloroeremomycin, a vancomycin-like glycopeptide. Oritavancin inhibits both transglycosylation and transpeptidation, by binding both the D-Ala-D-Ala and pentaglycine bridge segments of peptidoglycan to inhibit cell wall formation." [PMID:27904526, PMID:15954849, PMID:18258256] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:16136912 [Term] id: ARO:3000190 name: tet(O) namespace: antibiotic_resistance def: "Tet(O) is a ribosomal protection protein. It is associated with conjugative plasmids." [PMID:2841293, PMID:9848445] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(O)" EXACT CARD_Short_Name [] synonym: "tetO" EXACT [] [Term] id: ARO:3000191 name: tet(Q) namespace: antibiotic_resistance def: "Tet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria." [PMID:9372425, PMID:20826220] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(Q)" EXACT CARD_Short_Name [] synonym: "tetA(Q)" EXACT [] synonym: "tetQ" EXACT [] [Term] id: ARO:3000192 name: tet(S) namespace: antibiotic_resistance def: "Tet(S) is a ribosomal protection protein found in Gram-positive and Gram-negative strains. It is similar to tet(M) and tet(O)." [PMID:7840565, PMID:8370538] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(S)" EXACT CARD_Short_Name [] synonym: "tetS" EXACT [] [Term] id: ARO:3000193 name: tet(T) namespace: antibiotic_resistance def: "Tet(T) is a ribosomal protection protein of streptococci. It is similar to Tet(Q)." [PMID:8980765] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(T)" EXACT CARD_Short_Name [] synonym: "tetT" EXACT [] [Term] id: ARO:3000194 name: tet(W) namespace: antibiotic_resistance def: "Tet(W) is a ribosomal protection protein. It is associated with both conjugative and non conjugative DNA and has been found strains of Clostridioides difficile." [PMID:10681357] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(W)" EXACT CARD_Short_Name [] synonym: "tetW" EXACT [] [Term] id: ARO:3000195 name: tetB(P) namespace: antibiotic_resistance def: "TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein." [PMID:15837373] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tetB(P)" EXACT CARD_Short_Name [] synonym: "tetP" EXACT [] [Term] id: ARO:3000196 name: tet(32) namespace: antibiotic_resistance def: "Tet(32) is a tetracycline resistance gene similar to Tet(O), and binds to the ribosome to confer tetracycline resistance as a ribosomal protection protein." [PMID:11600392, PMID:18955517] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(32)" EXACT CARD_Short_Name [] synonym: "tet32" EXACT [] [Term] id: ARO:3000197 name: tet(36) namespace: antibiotic_resistance def: "Tet(36) is a tetracycline resistance gene found in Bacteroides similar to Tet(Q), and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein." [PMID:12839793] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(36)" EXACT CARD_Short_Name [] synonym: "tet36" EXACT [] [Term] id: ARO:3000198 name: FosX namespace: antibiotic_resistance def: "FosX is an enzyme used to confer resistance to fosfomycin. It's dependent on the cofactor, manganese (II), and uses water to generate a vicinal diol." [PMID:17567049] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosX" EXACT CARD_Short_Name [] xref: PDB:2P7K [Term] id: ARO:3000199 name: gramicidin D namespace: antibiotic_resistance def: "Gramicidin D is a mixture of the linear peptides gramicidin A, B, and C, each with 15 alternating L- and D-amino acids. They are active against most gram-positive bacteria and select gram-negative bacteria. These compounds create channels in the bacterial membrane and increase the permeability to cations." [PMID:17572379, PMID:9672588] is_a: ARO:3000123 ! gramicidin is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000222 ! gramicidin A relationship: has_part ARO:3000223 ! gramicidin B relationship: has_part ARO:3000224 ! gramicidin C xref: pubchem.compound:45267103 [Term] id: ARO:3000200 name: gramicidin S namespace: antibiotic_resistance def: "Gramicidin S is a cyclical decapeptide with two pentapeptides (Val-Orn-Leu-D-Phe-Pro) joined head to tail. Like other gramicidins, Gramicidin S disrupts membrane permeability of cations while also destabilizing the membrane at higher concentrations." [PMID:10590309, PMID:8836773] is_a: ARO:3000123 ! gramicidin xref: pubchem.compound:73357 [Term] id: ARO:3000201 name: macrolide inactivation enzyme namespace: antibiotic_resistance def: "Enzymes shown to inactivate macrolide antibiotics by chemical modification, thereby conferring resistance to macrolides." [] is_a: ARO:3000557 ! antibiotic inactivation enzyme [Term] id: ARO:3000202 name: Cfr 23S ribosomal RNA methyltransferase namespace: antibiotic_resistance def: "Cfr genes produce enzymes which catalyze the methylation of the 23S rRNA subunit at position 8 of adenine-2503. Methylation of 23S rRNA at this site confers resistance to some classes of antibiotics, including streptogramins, chloramphenicols, florfenicols, linezolids and clindamycin." [PMID:28663118, PMID:22547628, PMID:20144045, PMID:23752511, PMID:11476839, PMID:17555436, PMID:20598637] is_a: ARO:3004575 ! S-adenosylmethionine (SAM) superfamily relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic relationship: confers_resistance_to_drug_class ARO:3000079 ! oxazolidinone antibiotic relationship: confers_resistance_to_drug_class ARO:3000387 ! phenicol antibiotic [Term] id: ARO:3000203 name: hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase namespace: antibiotic_resistance def: "Mechanism of enzymatic degradation common to Ambler Class B beta-lactamases. One or two zinc atoms are used to orient a hydroxide nucleophile for attack of the beta-lactam ring. In contrast to serine beta-lactamases, no acyl-enzyme intermediate is formed." [PMID:20564281] is_a: ARO:3000040 ! hydrolysis of antibiotic conferring resistance [Term] id: ARO:3000205 name: tet(X) namespace: antibiotic_resistance def: "Tet(X) is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. Tet(X) hydroxylates position 11a of the tetraketide group thus inactivating the antibiotic." [PMID:15452119, PMID:1846135, PMID:21402075, PMID:16128584] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline relationship: participates_in ARO:3000450 ! hydroxylation of antibiotic conferring resistance synonym: "tet(X)" EXACT CARD_Short_Name [] synonym: "tetX" EXACT [] xref: PDB:2XYO [Term] id: ARO:3000206 name: emrK namespace: antibiotic_resistance def: "emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux." [PMID:12501312] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000373 ! EmrKY-TolC synonym: "emrK" EXACT CARD_Short_Name [] [Term] id: ARO:3000207 name: acrA namespace: antibiotic_resistance def: "Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein." [PMID:15226509, PMID:10931319, PMID:16531241, PMID:14706082] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000384 ! AcrAB-TolC [Term] id: ARO:3000208 name: glycosylation of antibiotic conferring resistance namespace: antibiotic_resistance def: "Addition of glycosyl moiety to antibiotics thereby inactivating them." [] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000209 name: antibiotic resistant DNA topoisomerase subunit parY namespace: antibiotic_resistance def: "ParY is part of a topoisomerase IV that is resistant to antibiotics that affect other topoisomerases." [] is_a: ARO:3000370 ! antibiotic resistant DNA topoisomerase subunit relationship: derives_from ARO:3003258 ! Antibiotic sensitive DNA topoisomerase subunit parY [Term] id: ARO:3000210 name: rifamycin-resistant beta-subunit of RNA polymerase (rpoB) namespace: antibiotic_resistance def: "Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin." [PMID:12821473, PMID:15047531, PMID:21300839, PMID:22361457, PMID:11136757, PMID:3050121, PMID:10543773] is_a: ARO:3000381 ! antibiotic target replacement protein is_a: ARO:3003276 ! antibiotic resistant rpoB relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic relationship: derives_from ARO:3000737 ! rifamycin sensitive beta-subunit of RNA polymerase (rpoB) [Term] id: ARO:3000211 name: ribosomal alteration conferring antibiotic resistance namespace: antibiotic_resistance def: "Chemical alteration of the ribosome results in modification of an antibiotic's target leading to resistance." [] is_a: ARO:0001001 ! antibiotic target alteration [Term] id: ARO:3000212 name: mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "Point mutations in the DNA may lead to an altered gene product that may result in antibiotic resistance. Examples included modified antibiotic targets with lower binding affinities and the deactivation of repressors that result in increased expression of genes that inactivate or pump out antibiotics." [] is_a: ARO:0001001 ! antibiotic target alteration [Term] id: ARO:3000213 name: restructuring of bacterial cell wall conferring antibiotic resistance namespace: antibiotic_resistance def: "Peptidoglycan precursors ending in D-Ala-D-Lac or D-Ala-D-Ser instead of D-Ala-D-Ala conferring high level glycopeptide resistance." [PMID:1931965, PMID:9177243] is_a: ARO:0001001 ! antibiotic target alteration synonym: "molecular bypass conferring antibiotic resistance" EXACT [] [Term] id: ARO:3000214 name: hygromycin B namespace: antibiotic_resistance def: "Hygromycin B is an aminoglycoside antibiotic used to treat different types of bacterial infections. Hygromycin B works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Hygromycin B has also been shown to interact with eukaryotic cells." [PMID:10103173, PMID:11163189] is_a: ARO:0000016 ! aminoglycoside antibiotic xref: pubchem.compound:35766 [Term] id: ARO:3000215 name: mecR1 namespace: antibiotic_resistance def: "mecR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the mecA/mecR1/mecI operon." [PMID:1544435] is_a: ARO:3000100 ! gene modulating beta-lactam resistance relationship: part_of ARO:3000268 ! mec operon relationship: regulates ARO:3000617 ! mecA relationship: regulates ARO:3001209 ! mecC synonym: "mecR1" EXACT CARD_Short_Name [] [Term] id: ARO:3000216 name: acrB namespace: antibiotic_resistance def: "Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter." [PMID:19453279, PMID:12374972, PMID:17275331, PMID:18073115, PMID:19166984] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: part_of ARO:3000384 ! AcrAB-TolC synonym: "ECK0456" EXACT [] synonym: "JW0451" EXACT [] synonym: "acrB" EXACT CARD_Short_Name [] xref: PDB:1IWG [Term] id: ARO:3000217 name: blaR1 namespace: antibiotic_resistance def: "blaR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the blaZ/blaR1/blaI operon." [] is_a: ARO:3000100 ! gene modulating beta-lactam resistance relationship: part_of ARO:3000262 ! bla operon relationship: regulates ARO:3000621 ! PC1 beta-lactamase (blaZ) synonym: "blaR1" EXACT CARD_Short_Name [] [Term] id: ARO:3000218 name: aminoglycoside nucleotidyltransferase (ANT) namespace: antibiotic_resistance def: "Covalent modification of aminoglycoside antibiotic hydroxyl group by ATP-dependent transfer of AMP." [PMID:20833577] is_a: ARO:3007380 ! aminoglycoside modifying enzyme relationship: participates_in ARO:3000107 ! nucleotidylation of antibiotic conferring resistance synonym: "aminoglycoside adenyltransferase" EXACT [] [Term] id: ARO:3000219 name: mutant efflux regulatory protein conferring antibiotic resistance namespace: antibiotic_resistance def: "Efflux regulatory proteins with mutations that result in increased expression of efflux proteins." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3000220 name: antibiotic resistant DNA topoisomerase subunit gyrB namespace: antibiotic_resistance def: "Point mutations in gyrB confer antibiotic resistance by preventing drugs from binding the beta-subunit of gyrase, essential for DNA supercoiling." [] is_a: ARO:3000370 ! antibiotic resistant DNA topoisomerase subunit relationship: derives_from ARO:3000734 ! antibiotic sensitive DNA topoisomerase subunit gyrB [Term] id: ARO:3000221 name: lincosamide nucleotidyltransferase (LNU) namespace: antibiotic_resistance def: "Resistance to the lincosamide antibiotic by ATP-dependent modification of the 3' and/or 4'-hydroxyl groups of the methylthiolincosamide sugar." [PMID:11797175] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic relationship: participates_in ARO:3000107 ! nucleotidylation of antibiotic conferring resistance [Term] id: ARO:3000222 name: gramicidin A namespace: antibiotic_resistance def: "Gramicidin A is the most abundant (more than 80%) of the three gramicidins in gramicidin D, with a tryptophan in position 11. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations." [PMID:17572379] is_a: ARO:3000123 ! gramicidin xref: pubchem.compound:16132269 [Term] id: ARO:3000223 name: gramicidin B namespace: antibiotic_resistance def: "Gramicidin B is one of the three gramicidins in gramicidin D, with a phenylalanine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations." [PMID:17572379] is_a: ARO:3000123 ! gramicidin xref: pubchem.compound:25244501 [Term] id: ARO:3000224 name: gramicidin C namespace: antibiotic_resistance def: "Gramicidin C is one of the three gramicidins in gramicidin D, with a tyrosine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations." [PMID:17572379] is_a: ARO:3000123 ! gramicidin xref: pubchem.compound:73357 [Term] id: ARO:3000225 name: ANT(6) namespace: antibiotic_resistance def: "A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 6-hydroxyl group of the compound." [] is_a: ARO:3000218 ! aminoglycoside nucleotidyltransferase (ANT) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000226 name: antibiotic resistant folP namespace: antibiotic_resistance def: "Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance." [PMID:9006040, PMID:9449266, PMID:21115799, PMID:1522070, PMID:9593127] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3000744 ! antibiotic sensitive dihydropteroate synthase synonym: "dihydropteroate synthase" EXACT [] [Term] id: ARO:3000227 name: tyrothricin namespace: antibiotic_resistance def: "Tyrothricin is a mixture of antibiotics including tyrocidines and gramicidins, isolated from Bacillus brevis." [PMID:16560680] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000123 ! gramicidin xref: pubchem.compound:452550 [Term] id: ARO:3000228 name: ANT(9) namespace: antibiotic_resistance def: "A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 9-hydroxyl group of the compound." [] is_a: ARO:3000218 ! aminoglycoside nucleotidyltransferase (ANT) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000229 name: ANT(4') namespace: antibiotic_resistance def: "A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 4'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 4-hydroxyl group of the compound." [] is_a: ARO:3000218 ! aminoglycoside nucleotidyltransferase (ANT) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic synonym: "aadD" EXACT [] synonym: "ant(4',4'')" EXACT [] [Term] id: ARO:3000230 name: ANT(2'')-Ia namespace: antibiotic_resistance def: "Plasmid or integron-encoded nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 2'' in P. aeruginosa, K. pneumoniae, Morganella morganii, E. coli, S. typhimurium, C. freundii and A. baumannii." [PMID:25564464, PMID:3024112] is_a: ARO:3007405 ! ANT(2'')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "ANT(2'')-Ia" EXACT CARD_Short_Name [] synonym: "aadB" EXACT [] [Term] id: ARO:3000231 name: beta-lactam resistance operon namespace: antibiotic_resistance def: "An operon conferring resistance to beta-lactam antibiotics." [] is_a: ARO:0000010 ! antibiotic resistance gene cluster, cassette, or operon [Term] id: ARO:3000232 name: ANT(3'')-Ia namespace: antibiotic_resistance def: "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''." [] is_a: ARO:3007407 ! ANT(3'')-I [Term] id: ARO:3000233 name: streptogramin inactivation enzyme namespace: antibiotic_resistance def: "Resistance to streptogramin antibiotics may be conferred through enzymatic inactivation. There are two known mechanisms of streptogramin inactivation shown clinically to confer resistance: 1) vgB lyase enzymes linearize type B streptogramin antibiotics by breaking the ester linkage; 2) vat acetyltransferase enzymes modify type A streptogramin antibiotics by transferring an acetyl group from acetyl-CoA to the secondary streptogramin hydroxyl. Both mechanisms result in antibiotic inactivation thus conferring resistance." [PMID:11467949, PMID:12771141] is_a: ARO:3000557 ! antibiotic inactivation enzyme [Term] id: ARO:3000234 name: glycopeptide resistance gene cluster namespace: antibiotic_resistance def: "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics." [PMID:16323116] is_a: ARO:0000010 ! antibiotic resistance gene cluster, cassette, or operon relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic relationship: participates_in ARO:3000213 ! restructuring of bacterial cell wall conferring antibiotic resistance [Term] id: ARO:3000235 name: ethambutol resistant embB namespace: antibiotic_resistance def: "embB gene encodes for an arabinosyl transferase in the arabinogalactan synthesis pathway. It is inhibited by ethambutol. Mutations within the ERDR region of embB confers resistance to ethambutol." [PMID:21444710, PMID:21300839, PMID:9142129] is_a: ARO:3005005 ! antibiotic-resistant emb arabinosyltransferase relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic relationship: derives_from ARO:3000765 ! antibiotic sensitive embB [Term] id: ARO:3000236 name: glycopeptide resistance gene cluster VanA namespace: antibiotic_resistance def: "This inducible cluster confers high resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. The vanA gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSHAXYZ." [PMID:16323116, PMID:8843432, PMID:8380148] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_antibiotic ARO:0000029 ! teicoplanin synonym: "vanA_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000237 name: TolC namespace: antibiotic_resistance def: "TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex." [PMID:10879525, PMID:12163644, PMID:14630321, PMID:16359323, PMID:11589692] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000344 ! EmrAB-TolC relationship: part_of ARO:3000373 ! EmrKY-TolC relationship: part_of ARO:3000384 ! AcrAB-TolC relationship: part_of ARO:3000503 ! AcrEF-TolC relationship: part_of ARO:3000545 ! MacAB-TolC relationship: part_of ARO:3000787 ! MdtABC-TolC relationship: part_of ARO:3000788 ! MdtEF-TolC relationship: part_of ARO:3004083 ! AcrEF-TolC confers resistance to ciprofloxacin relationship: part_of ARO:3004598 ! Klebsiella pneumoniae KpnGH-TolC synonym: "TolC" EXACT CARD_Short_Name [] xref: PDB:1EK9 [Term] id: ARO:3000238 name: glycopeptide resistance gene cluster VanB namespace: antibiotic_resistance def: "This inducible cluster confers resistance to vancomycin but organisms remain sensitive to teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Sensitivity to teicoplanin is due to lack of binding to the sensor kinase VanS. The vanB gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSYWHBX." [PMID:8654967, PMID:16323116] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "vanB_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000244 name: reduced permeability to antibiotic namespace: antibiotic_resistance def: "Reduction in permeability to antibiotic, generally through reduced production of porins, can provide resistance." [PMID:19100346, PMID:2848006] is_a: ARO:1000002 ! mechanism of antibiotic resistance [Term] id: ARO:3000245 name: RbpA namespace: antibiotic_resistance def: "RNA-polymerase binding protein which confers resistance to rifampin." [PMID:16629670, PMID:21415119] is_a: ARO:3004243 ! RbpA bacterial RNA polymerase-binding protein relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "RbpA" EXACT CARD_Short_Name [] [Term] id: ARO:3000246 name: glycopeptide resistance gene cluster VanC namespace: antibiotic_resistance def: "Confers low vancomycin resistance by engineering peptidoglycan precursors ending in D-Ala-D-Ser in an inducible or constitutive manner. The vanC cluster is intrinsic to the Enterococcus gallinarum chromosome. vanC organisms remain susceptible to teicoplanin. Gene orientation: vanC(XY)TRS." [PMID:1551598, PMID:10817725, PMID:16323116, PMID:12615855, PMID:7986009] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "vanC_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000247 name: phosphoenolpyruvate (PEP) mutase namespace: antibiotic_resistance def: "A tetrameric protein that converts phosphoenolpyruvate (PEP) to phosponopyruvate (Ppyr)." [PMID:15078090] is_a: ARO:3000082 ! antibiotic biosynthesis synonym: "Fom1" EXACT [] xref: PDB:1S2T [Term] id: ARO:3000248 name: DnaA namespace: antibiotic_resistance def: "DnaA is a chromosomal replication initiation protein which binds and interacts with RNA polymerase in Escherichia coli. A surplus of DnaA present in a cell has been shown to confer resistance to the antibiotic Rifampicin. Normally, rifampicin inhibits initiation of transcription by RNA polymerase, but a surplus of DnaA available at the origin has been shown to disrupt Rifampicin activity and confer resistance." [PMID:19170875] is_a: ARO:3004244 ! DnaA chromosomal replication initiation protein relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "DnaA" EXACT CARD_Short_Name [] [Term] id: ARO:3000249 name: chloramphenicol phosphotransferase namespace: antibiotic_resistance def: "ATP-dependent kinase modifies the C-3 hydroxyl group of chloramphenicol. Source is the chloramphenicol producer Streptomyces venezuelae." [PMID:10835366, PMID:7592948] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000387 ! phenicol antibiotic relationship: participates_in ARO:3000105 ! phosphorylation of antibiotic conferring resistance [Term] id: ARO:3000250 name: ErmC namespace: antibiotic_resistance def: "ErmC is a methyltransferase that catalyzes the methylation of A2058 of the 23S ribosomal RNA in two steps. Expression of ErmC is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmC." [PMID:2492520, PMID:6792593, PMID:18439898, PMID:2113911] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmC" EXACT CARD_Short_Name [] synonym: "ErmC'" EXACT [] synonym: "ermIM" EXACT [] synonym: "ermM" EXACT [] [Term] id: ARO:3000251 name: msrA namespace: antibiotic_resistance def: "MsrA is an ABC-F subfamily ribosomal protection protein expressed in Staphylococcus species which confers resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. It is associated with plasmid DNA." [PMID:15914491] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin synonym: "msr(A)" EXACT [] synonym: "msrA" EXACT CARD_Short_Name [] [Term] id: ARO:3000253 name: glycopeptide resistance gene cluster VanD namespace: antibiotic_resistance def: "Homologous to vanA, contains a D-Ala-D-Lac ligase. This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin. Gene orientation: vanRSYHDX." [PMID:11344152, PMID:12499162, PMID:9303405, PMID:16323116] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_antibiotic ARO:0000029 ! teicoplanin synonym: "vanD_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000254 name: emrY namespace: antibiotic_resistance def: "emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB." [PMID:12501312] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000373 ! EmrKY-TolC synonym: "emrY" EXACT CARD_Short_Name [] [Term] id: ARO:3000255 name: glycopeptide resistance gene cluster VanF namespace: antibiotic_resistance def: "Homologous to vanA, contains a D-Ala-D-Lac ligase. The vanF gene cluster is inducible and confers high resistance to vancomycin in Paenibacillus popilliae. vanF organisms remain susceptible to teicoplanin. Gene orientation: RSYZHFX." [PMID:10681342, PMID:15980329] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "vanF_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000256 name: glycopeptide resistance gene cluster VanM namespace: antibiotic_resistance def: "Homologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX." [PMID:20733041] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_antibiotic ARO:0000029 ! teicoplanin synonym: "vanM_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000257 name: glycopeptide resistance gene cluster VanG namespace: antibiotic_resistance def: "Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes. Gene orientation: vanRSYWGYT." [PMID:19851013, PMID:16323116, PMID:11036060] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "vanG_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000259 name: glycopeptide resistance gene cluster VanE namespace: antibiotic_resistance def: "Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanE gene cluster is inducible and confers low resistance to vancomycin. vanE organisms remain susceptible to teicoplanin. Gene orientation: E(XY)TRS." [PMID:12426332, PMID:10471558, PMID:16323116, PMID:12019119] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "vanE_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000260 name: glycopeptide resistance gene cluster VanL namespace: antibiotic_resistance def: "Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes. Gene orientation: vanL(XY)TmTrRS." [PMID:18458129] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "vanL_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3000261 name: sigma factor conferring resistance to rifampin namespace: antibiotic_resistance def: "When bound to different sigma factors, RNA-polymerase may possess an altered sensitivity to rifampin-mediated inhibition." [PMID:9862449] is_a: ARO:3000507 ! rifampin-resistant RNA polymerase-binding protein relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine [Term] id: ARO:3000262 name: bla operon namespace: antibiotic_resistance def: "The bla operon is composed of blaZ/blaR1/blaI." [] is_a: ARO:3000231 ! beta-lactam resistance operon [Term] id: ARO:3000263 name: marA namespace: antibiotic_resistance def: "In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF." [PMID:12027588, PMID:2848006, PMID:9333027] is_a: ARO:3000270 ! protein modulating permeability to antibiotic is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000265 ! porin OmpF relationship: regulates ARO:3000384 ! AcrAB-TolC synonym: "marA" EXACT CARD_Short_Name [] [Term] id: ARO:3000264 name: emrE namespace: antibiotic_resistance def: "EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. EmrE is found in E. coli and P. aeruginosa." [PMID:17360700, PMID:18006522, PMID:17976529, PMID:19167526, PMID:17942072, PMID:19171974, PMID:12499164] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump [Term] id: ARO:3000265 name: porin OmpF namespace: antibiotic_resistance def: "In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF." [PMID:2848006, PMID:19100346] is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams [Term] id: ARO:3000266 name: ADP-ribosylation of antibiotic conferring resistance namespace: antibiotic_resistance def: "The inactivation of antibiotics by the enzymatic addition of ADP-ribose from NAD+." [] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000268 name: mec operon namespace: antibiotic_resistance def: "The mec operon is composed of mecA/mecR1/mecI." [] is_a: ARO:3000231 ! beta-lactam resistance operon [Term] id: ARO:3000269 name: brodimoprim namespace: antibiotic_resistance def: "Brodimoprim is a structural derivative of trimethoprim and an inhibitor of bacterial dihydrofolate reductase. The 4-methoxy group of trimethoprim is replaced with a bromine atom." [PMID:8195838, PMID:7562018, PMID:10026296] is_a: ARO:3000171 ! diaminopyrimidine antibiotic xref: pubchem.compound:68760 [Term] id: ARO:3000270 name: protein modulating permeability to antibiotic namespace: antibiotic_resistance def: "Enzymes or other proteins either directly or indirectly reducing overall permeability to antibiotics." [PMID:2848006, PMID:19100346] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:3000244 ! reduced permeability to antibiotic [Term] id: ARO:3000273 name: antibiotic resistant DNA topoisomerase subunit gyrA namespace: antibiotic_resistance def: "Point mutations in gyrA confer antibiotic resistance by preventing drugs from binding the alpha-subunit of gyrase, essential for DNA supercoiling." [] is_a: ARO:3000370 ! antibiotic resistant DNA topoisomerase subunit relationship: derives_from ARO:3003254 ! antibiotic sensitive DNA topoisomerase subunit gyrA [Term] id: ARO:3000274 name: antibiotic resistant DNA topoisomerase subunit parC namespace: antibiotic_resistance def: "Point mutations in parC confer antibiotic resistance by preventing drugs from binding the parC subunit of topoisomerase IV, essential for DNA decatanation and relaxation." [] is_a: ARO:3000370 ! antibiotic resistant DNA topoisomerase subunit relationship: derives_from ARO:3003256 ! antibiotic sensitive DNA topoisomerase subunit parC [Term] id: ARO:3000276 name: cephem namespace: antibiotic_resistance def: "Cephems have a six-membered dihydrothiazine ring with a sulfur atom and double bond fused with its beta-lactam ring. This group includes the cephalosporins and cephamycins, the latter containing an additional alpha-methoxy group." [] is_a: ARO:3000007 ! beta-lactam antibiotic [Term] id: ARO:3000282 name: sulfonamide antibiotic namespace: antibiotic_resistance def: "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway." [PMID:15673783] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000284 name: tetroxoprim namespace: antibiotic_resistance def: "Tetroxoprim is a trimethoprim derivative that inhibits bacterial dihydrofolate reductase." [PMID:7036848, PMID:3043259] is_a: ARO:3000171 ! diaminopyrimidine antibiotic xref: pubchem.compound:65450 [Term] id: ARO:3000299 name: phosphonopyruvate decarboxylase namespace: antibiotic_resistance def: "Stabilizes the C-P bond in phosphonopyruvate formed by phophoenolpyruvate mutase by catalyzing the self-removal of the carboxyl group." [PMID:10786631] is_a: ARO:3000082 ! antibiotic biosynthesis synonym: "Fom2" EXACT [] [Term] id: ARO:3000300 name: lsaA namespace: antibiotic_resistance def: "LsaA is an ABC-F subfamily protein expressed in Enterococcus faecalis. It confers resistance to clindamycin, quinupristin-dalfopristin, and dalfopristin." [PMID:15914491, PMID:21245447, PMID:12019099] is_a: ARO:3004472 ! lsa-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3001317 ! pleuromutilin synonym: "lsaA" EXACT CARD_Short_Name [] [Term] id: ARO:3000309 name: emrD namespace: antibiotic_resistance def: "EmrD is a multidrug transporter from the Major Facilitator Superfamily (MFS) primarily found in Escherichia coli. EmrD couples efflux of amphipathic compounds with proton import across the plasma membrane." [PMID:16675700, PMID:16842212, PMID:8240355, PMID:8987357] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics synonym: "emrD" EXACT CARD_Short_Name [] xref: PDB:2GFP [Term] id: ARO:3000316 name: mphA namespace: antibiotic_resistance def: "The mphA gene encodes for resistance enzyme MPH(2')-I which preferentially inactivate 14-membered macrolides (e.g.erythromycin, telithromycin, roxithromycin) over 16-membered macrolides (e.g.tylosin, spiramycin). It phosphorylates macrolides at 2'-OH hydroxyl of desosamine sugar of macrolides in a GTP-dependent manner." [PMID:20231391, PMID:29317655, PMID:17302923, PMID:8619599] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "macrolide 2'-phosphotransferase I" EXACT [] synonym: "mphA" EXACT CARD_Short_Name [] [Term] id: ARO:3000318 name: mphB namespace: antibiotic_resistance def: "The mphB gene encodes for MPH(2')-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2'-OH hydroxyl of desosamine sugar of macrolides." [PMID:9503630, PMID:17302923, PMID:29317655, PMID:8900063, PMID:1330822] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "macrolide 2'-phosphotransferase II" EXACT [] synonym: "mphB" EXACT CARD_Short_Name [] [Term] id: ARO:3000319 name: mphC namespace: antibiotic_resistance def: "The mphC gene was identified from Staphylococcus aureus. This gene shows similarity to mphB gene from Escherchia coli." [PMID:17302923, PMID:29317655, PMID:12670694] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "mphC" EXACT CARD_Short_Name [] [Term] id: ARO:3000320 name: macrolide esterase namespace: antibiotic_resistance def: "Hydrolytic enzymes that cleave the macrocycle lactone ring of macrolide antibiotics." [PMID:22303981] is_a: ARO:3000201 ! macrolide inactivation enzyme relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: participates_in ARO:3000321 ! hydrolysis of macrolide macrocycle lactone ring [Term] id: ARO:3000321 name: hydrolysis of macrolide macrocycle lactone ring namespace: antibiotic_resistance def: "Hydrolysis of the the macrocycle lactone ring of macrolide antibiotics." [] is_a: ARO:3000040 ! hydrolysis of antibiotic conferring resistance [Term] id: ARO:3000322 name: AAC(3) namespace: antibiotic_resistance def: "A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound." [PMID:10639379, PMID:15728939, PMID:18476779, PMID:15388438, PMID:8257126, PMID:2060791, PMID:19709289, PMID:2549372, PMID:12709352, PMID:6318050, PMID:1649572, PMID:3892230, PMID:7486920, PMID:18467306, PMID:2914849, PMID:1577689, PMID:19949054] is_a: ARO:3000121 ! aminoglycoside acetyltransferase (AAC) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000324 name: sulfadiazine namespace: antibiotic_resistance def: "Sulfadiazine is a potent inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids." [PMID:4597736] is_a: ARO:3000282 ! sulfonamide antibiotic xref: pubchem.compound:5215 [Term] id: ARO:3000325 name: sulfadimidine namespace: antibiotic_resistance def: "Sulfadimidine is an alkaline sulfonamide antibiotic that inhibits dihydropteroate synthase, and enzyme in the tetrahydrofolic acid biosynthesis pathway. This interferes with the production of folate, which is a precursor to many amino acids and nucleotides." [PMID:15673783] is_a: ARO:3000282 ! sulfonamide antibiotic synonym: "sulfamethazine" EXACT [] xref: pubchem.compound:5327 [Term] id: ARO:3000326 name: ErmE namespace: antibiotic_resistance def: "ErmE is a methyltransferase found in the erythromycin producer Saccharopolyspora erythraea. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance." [PMID:7961464, PMID:9973557, PMID:9735285, PMID:12019067, PMID:3117622] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmE" EXACT CARD_Short_Name [] synonym: "ermE2" EXACT [] [Term] id: ARO:3000327 name: sulfadoxine namespace: antibiotic_resistance def: "Sulfadoxine is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids." [PMID:21029476] is_a: ARO:3000282 ! sulfonamide antibiotic xref: pubchem.compound:17134 [Term] id: ARO:3000328 name: rRNA with mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "Single nucleotide polymorphisms (SNPs) in rRNA can confer antibiotic resistance to drugs that target the bacterial ribosome." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3000740 ! ribonucleic acid [Term] id: ARO:3000329 name: sulfamethoxazole namespace: antibiotic_resistance def: "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides." [PMID:1093654] is_a: ARO:3000282 ! sulfonamide antibiotic xref: pubchem.compound:5329 [Term] id: ARO:3000330 name: sulfisoxazole namespace: antibiotic_resistance def: "Sulfisoxazole is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids." [PMID:978409] is_a: ARO:3000282 ! sulfonamide antibiotic xref: pubchem.compound:5344 [Term] id: ARO:3000333 name: macrolide phosphotransferase (MPH) namespace: antibiotic_resistance def: "Macrolide phosphotransferases (MPH) are enzymes encoded by macrolide phosphotransferase genes (mph genes). These enzymes phosphorylate macrolides in GTP dependent manner at 2'-OH of desosamine sugar thereby inactivating them. Characterized MPH's are differentiated based on their substrate specificity." [] is_a: ARO:3000201 ! macrolide inactivation enzyme relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: participates_in ARO:3000105 ! phosphorylation of antibiotic conferring resistance [Term] id: ARO:3000336 name: 23S rRNA with mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "Point mutations in bacterial 23S rRNA from the large ribosomal subunit that confer resistance to antibiotics. Antibiotics such as linezolid block peptide synthesis through peptidyl transferase activity. Mutations in the 23S rRNA subunit reduce antibiotic binding affinity at specific sites, conferring resistance." [PMID:18174304, PMID:15700955] is_a: ARO:3000328 ! rRNA with mutation conferring antibiotic resistance relationship: derives_from ARO:3000754 ! antibiotic sensitive peptidyl transferase (23S rRNA) [Term] id: ARO:3000337 name: iclaprim namespace: antibiotic_resistance def: "Iclaprim is a bactericidal compound that inhibits dihydrofolate reductase. It is used against clinically important Gram-positive pathogens, including methicillin-sensitive Staphylococcus aureus and methicillin-resistant S. aureus." [PMID:19289528, PMID:19622858] is_a: ARO:3000171 ! diaminopyrimidine antibiotic synonym: "AR-100" EXACT [] synonym: "RO-48-2622" EXACT [] xref: pubchem.compound:213043 [Term] id: ARO:3000338 name: linearization of antibiotic conferring resistance namespace: antibiotic_resistance def: "Genes that confer antibiotic resistance by hydrolyzing bonds to linearize and deactivate antibiotics." [] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000341 name: AAC(2') namespace: antibiotic_resistance def: "A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound." [PMID:9159528, PMID:8407825, PMID:18931120] is_a: ARO:3000121 ! aminoglycoside acetyltransferase (AAC) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000342 name: fosfomycin inactivation enzyme namespace: antibiotic_resistance def: "Enzymes that inactivate fosfomycin by chemical modification." [] is_a: ARO:3000557 ! antibiotic inactivation enzyme [Term] id: ARO:3000343 name: tap namespace: antibiotic_resistance def: "Efflux pump proteins contained within Mycobacterial genomes which confer resistance to a number of different antibiotics including aminoglycosides, and tetracyclines." [PMID:15057575, PMID:9811639] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tap" EXACT CARD_Short_Name [] [Term] id: ARO:3000344 name: EmrAB-TolC namespace: antibiotic_resistance def: "EmrAB-TolC is a multidrug efflux system found in E. coli. EmrB is the electrochemical-gradient powered transporter; EmrA is the linker; and TolC is the outer membrane channel. It confers resistance to nalidixic acid and thiolactomycin." [PMID:7730261] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid synonym: "EmrAB-TolC" EXACT CARD_Short_Name [] [Term] id: ARO:3000345 name: AAC(6') namespace: antibiotic_resistance def: "A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound." [PMID:15673721] is_a: ARO:3000121 ! aminoglycoside acetyltransferase (AAC) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3000347 name: ErmA namespace: antibiotic_resistance def: "ErmA confers the MLSb phenotype. Similar to ErmC, Expression of ErmA is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmA." [PMID:18952616] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmA" EXACT CARD_Short_Name [] synonym: "ermTR" EXACT [] [Term] id: ARO:3000359 name: fosfomycin phosphotransferase namespace: antibiotic_resistance def: "In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic." [PMID:18701452, PMID:10681332] is_a: ARO:3000342 ! fosfomycin inactivation enzyme relationship: participates_in ARO:3000105 ! phosphorylation of antibiotic conferring resistance [Term] id: ARO:3000361 name: EreA namespace: antibiotic_resistance def: "EreA is an erythromycin esterase that hydrolyses the drug's lactone ring." [PMID:22303981] is_a: ARO:3000320 ! macrolide esterase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Ere(A)" EXACT [] synonym: "EreA" EXACT CARD_Short_Name [] [Term] id: ARO:3000363 name: EreB namespace: antibiotic_resistance def: "EreB is an erythromycin esterase-like protein that hydrolyses the drug's lactone ring." [PMID:10908116] is_a: ARO:3000320 ! macrolide esterase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Ere(B)" EXACT [] synonym: "EreB" EXACT CARD_Short_Name [] [Term] id: ARO:3000368 name: vanC namespace: antibiotic_resistance def: "VanC is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is specific to Enterococcus gallinarum and E. casseliflavus, providing intrinsic resistance." [PMID:1551598, PMID:16323116, PMID:9666008] is_a: ARO:3002979 ! D-Ala-D-Ser ligase relationship: part_of ARO:3000246 ! glycopeptide resistance gene cluster VanC synonym: "vanC" EXACT CARD_Short_Name [] [Term] id: ARO:3000369 name: MtrCDE namespace: antibiotic_resistance def: "The mtr (multiple transferable resistance) system of Neisseria gonorrhoeae confers resistance to many hydrophobic agents including antibiotics, fatty-acids and detergents. MtrCDE is homologous to AcrAB-TolC, where MtrC is the membrane fusion protein, MtrD is the inner membrane transporter, and MtrE is the outer membrane channel protein." [PMID:7711899, PMID:14500476] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000054 ! penicillin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "MtrCDE" EXACT CARD_Short_Name [] [Term] id: ARO:3000370 name: antibiotic resistant DNA topoisomerase subunit namespace: antibiotic_resistance def: "Many drugs target topoisomerases to inhibit DNA synthesis. Resistant DNA topoisomerase subunits prevent antibiotic binding and thus confer resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3000766 ! antibiotic sensitive topoisomerase subunit [Term] id: ARO:3000372 name: vanT namespace: antibiotic_resistance def: "VanT is a membrane bound serine racemase, converting L-serine to D-serine. It is associated with VanC, which incorporated D-serine into D-Ala-D-Ser terminal end of peptidoglycan subunits that have a decreased binding affinity with vancomycin. It was isolated from Enterococcus gallinarum." [PMID:10878136, PMID:10817725] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000373 name: EmrKY-TolC namespace: antibiotic_resistance def: "EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter." [PMID:21954395, PMID:12501312] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "EmrKY-TolC" EXACT CARD_Short_Name [] [Term] id: ARO:3000375 name: ErmB namespace: antibiotic_resistance def: "ErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB." [PMID:18299414, PMID:10508434, PMID:9187657] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmB" EXACT CARD_Short_Name [] synonym: "erm" EXACT [] synonym: "erm2" EXACT [] synonym: "ermAM" EXACT [] synonym: "ermAMR" EXACT [] synonym: "ermBC" EXACT [] synonym: "ermBP" EXACT [] synonym: "ermBZ1" EXACT [] synonym: "ermBZ2" EXACT [] synonym: "ermIP" EXACT [] synonym: "ermP" EXACT [] xref: PDB:1YUB [Term] id: ARO:3000376 name: streptogramin vgb lyase namespace: antibiotic_resistance def: "vgb (Virginiamycin B) lyase inactivates type B streptogramin antibiotics by linearizing the streptogramin lactone ring at the ester linkage through an elimination mechanism, thus conferring resistance to these compounds." [PMID:11467949] is_a: ARO:3000233 ! streptogramin inactivation enzyme relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic relationship: participates_in ARO:3000338 ! linearization of antibiotic conferring resistance [Term] id: ARO:3000377 name: MexA namespace: antibiotic_resistance def: "MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex." [PMID:15117957] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000386 ! MexAB-OprM relationship: part_of ARO:3004048 ! MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin relationship: part_of ARO:3004051 ! MexAB-OprM with NalC mutations conferring resistance to aztreonam relationship: part_of ARO:3004052 ! MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics relationship: part_of ARO:3004053 ! MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam relationship: part_of ARO:3004080 ! MexAB-OprM with MexR mutations confers resistance to multiple antibiotics synonym: "MexA" EXACT CARD_Short_Name [] xref: PDB:1T5E [Term] id: ARO:3000378 name: MexB namespace: antibiotic_resistance def: "MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM." [PMID:14973037, PMID:21178960, PMID:19361527, PMID:20583998] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000386 ! MexAB-OprM relationship: part_of ARO:3004048 ! MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin relationship: part_of ARO:3004051 ! MexAB-OprM with NalC mutations conferring resistance to aztreonam relationship: part_of ARO:3004052 ! MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics relationship: part_of ARO:3004053 ! MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam relationship: part_of ARO:3004080 ! MexAB-OprM with MexR mutations confers resistance to multiple antibiotics synonym: "MexB" EXACT CARD_Short_Name [] xref: PDB:2V50 [Term] id: ARO:3000379 name: OprM namespace: antibiotic_resistance def: "OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex." [PMID:16511029, PMID:16508113, PMID:15797729] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000386 ! MexAB-OprM relationship: part_of ARO:3002981 ! AmrAB-OprM relationship: part_of ARO:3003029 ! MexVW-OprM relationship: part_of ARO:3003032 ! MexXY-OprM relationship: part_of ARO:3003694 ! MexJK-OprM relationship: part_of ARO:3003703 ! MexMN-OprM relationship: part_of ARO:3004048 ! MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin relationship: part_of ARO:3004051 ! MexAB-OprM with NalC mutations conferring resistance to aztreonam relationship: part_of ARO:3004052 ! MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics relationship: part_of ARO:3004053 ! MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam relationship: part_of ARO:3004080 ! MexAB-OprM with MexR mutations confers resistance to multiple antibiotics synonym: "OprM" EXACT CARD_Short_Name [] xref: PDB:1WP1 [Term] id: ARO:3000380 name: FosC namespace: antibiotic_resistance def: "FosC is an enzyme that phosphorylates fosfomycin to confer resistance." [PMID:7492106] is_a: ARO:3004245 ! fosC phosphotransferase family relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosC" EXACT CARD_Short_Name [] [Term] id: ARO:3000381 name: antibiotic target replacement protein namespace: antibiotic_resistance def: "Alternate proteins that have the same functions as other antibiotic target proteins, but are structurally different and thus resistant to antibiotics. These can replace the activity of other antibiotic-sensitive proteins in the presence of antibiotics." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:0001002 ! antibiotic target replacement [Term] id: ARO:3000382 name: azidamfenicol namespace: antibiotic_resistance def: "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit." [PMID:15539072] is_a: ARO:3000387 ! phenicol antibiotic xref: pubchem.compound:62858 [Term] id: ARO:3000384 name: AcrAB-TolC namespace: antibiotic_resistance def: "AcrAB-TolC is a tripartite RND efflux system that confers resistance to tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin in Gram-negative bacteria. The system spans the cell membrane (AcrB) and the outer-membrane (TolC), and is linked together in the periplasm by AcrA." [PMID:8550435, PMID:21513882] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "AcrAB-TolC" EXACT CARD_Short_Name [] [Term] id: ARO:3000385 name: chloramphenicol namespace: antibiotic_resistance def: "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation." [PMID:17737966] is_a: ARO:3000387 ! phenicol antibiotic synonym: "CHL" EXACT [] xref: pubchem.compound:5959 [Term] id: ARO:3000386 name: MexAB-OprM namespace: antibiotic_resistance def: "MexAB-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexA is the membrane fusion protein; MexB is the inner membrane transporter; and OprM is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, erythromycin, azithromycin, novobiocin, and certain β-lactams and lastly over-expression is linked to colistin resistance." [PMID:9449262, PMID:17586626, PMID:18312276, PMID:16189126, PMID:18676884] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3003708 ! panipenem relationship: confers_resistance_to_antibiotic ARO:3004024 ! trimethoprim-sulfamethoxazole relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3000282 ! sulfonamide antibiotic relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3000387 name: phenicol antibiotic namespace: antibiotic_resistance def: "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome." [PMID:12860128] is_a: ARO:1000003 ! antibiotic molecule synonym: "phenicol" EXACT [] [Term] id: ARO:3000388 name: streptogramin biosynthesis namespace: antibiotic_resistance def: "Biosynthesis of streptoramin antibiotics." [] is_a: ARO:3000082 ! antibiotic biosynthesis [Term] id: ARO:3000389 name: streptogramin B biosynthesis namespace: antibiotic_resistance def: "Type B streptogramins are cyclic hexa- or hepta-depsipeptides produced by NRPSs in Streptomyces. The NRPS contains 6 or 7 modules arranged on one or more genes. SnbA catalyzes the activation of the first residue, 3-hydroxypicolynic acid. SnbC then activates and incorporates threonine and aminobutyric acid. Lastly, SnbDE activates and incoporates the last four amino acids. The thioesterase domain is responsible for peptide cyclization, and it is located at the end of the assembly line." [PMID:900602, PMID:9303382, PMID:9006023] is_a: ARO:3000388 ! streptogramin biosynthesis [Term] id: ARO:3000390 name: rifampin ADP-ribosyltransferase (Arr) namespace: antibiotic_resistance def: "Enzyme responsible for the ADP-ribosylative inactivation of rifampin at the 23-OH position using NAD+." [PMID:18349144, PMID:9869590] is_a: ARO:3000576 ! rifampin inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic relationship: participates_in ARO:3000266 ! ADP-ribosylation of antibiotic conferring resistance [Term] id: ARO:3000391 name: norA namespace: antibiotic_resistance def: "NorA is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like acriflavine. It shares 30% similarity with NorA, and is a structural homolog of Bmr of Bacillus subtilis. It is regulated by arlRS and mgrA, the latter also known as NorR." [PMID:8431010, PMID:12730173, PMID:15774883] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "norA" EXACT CARD_Short_Name [] [Term] id: ARO:3000392 name: Erm(37) namespace: antibiotic_resistance def: "Erm(37) is found in Mycobacterium species and confers the MLSb phenotype. In addition to methylation of A2058 this Erm methylates adjacent adenosines (A2057 and A2059) as well." [PMID:14693532, PMID:16174779] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "Erm(37)" EXACT CARD_Short_Name [] synonym: "Erm37" EXACT [] [Term] id: ARO:3000393 name: glycopeptide biosynthesis namespace: antibiotic_resistance def: "Synthesis of glycopeptide antibiotics." [] is_a: ARO:3000082 ! antibiotic biosynthesis [Term] id: ARO:3000394 name: Actinoplanes teichomyceticus teicoplanin gene cluster namespace: antibiotic_resistance def: "Biosynthesis of teicoplanin by Actinoplanes teichomyceticus." [PMID:15113000] is_a: ARO:3000393 ! glycopeptide biosynthesis [Term] id: ARO:3000410 name: sul1 namespace: antibiotic_resistance def: "Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons." [PMID:17158944, PMID:21537009, PMID:19075060, PMID:18753343, PMID:11432417, PMID:17827139] is_a: ARO:3004238 ! sulfonamide resistant sul relationship: confers_resistance_to_antibiotic ARO:3000324 ! sulfadiazine relationship: confers_resistance_to_antibiotic ARO:3000325 ! sulfadimidine relationship: confers_resistance_to_antibiotic ARO:3000327 ! sulfadoxine relationship: confers_resistance_to_antibiotic ARO:3000329 ! sulfamethoxazole relationship: confers_resistance_to_antibiotic ARO:3000330 ! sulfisoxazole relationship: confers_resistance_to_antibiotic ARO:3000683 ! sulfacetamide relationship: confers_resistance_to_antibiotic ARO:3000684 ! mafenide relationship: confers_resistance_to_antibiotic ARO:3000698 ! sulfasalazine relationship: confers_resistance_to_antibiotic ARO:3000699 ! sulfamethizole relationship: derives_from ARO:3000744 ! antibiotic sensitive dihydropteroate synthase synonym: "sul1" EXACT CARD_Short_Name [] [Term] id: ARO:3000412 name: sul2 namespace: antibiotic_resistance def: "Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids." [PMID:11432417, PMID:15722395] is_a: ARO:3004238 ! sulfonamide resistant sul relationship: confers_resistance_to_antibiotic ARO:3000324 ! sulfadiazine relationship: confers_resistance_to_antibiotic ARO:3000325 ! sulfadimidine relationship: confers_resistance_to_antibiotic ARO:3000327 ! sulfadoxine relationship: confers_resistance_to_antibiotic ARO:3000329 ! sulfamethoxazole relationship: confers_resistance_to_antibiotic ARO:3000330 ! sulfisoxazole relationship: confers_resistance_to_antibiotic ARO:3000683 ! sulfacetamide relationship: confers_resistance_to_antibiotic ARO:3000684 ! mafenide relationship: confers_resistance_to_antibiotic ARO:3000698 ! sulfasalazine relationship: confers_resistance_to_antibiotic ARO:3000699 ! sulfamethizole relationship: derives_from ARO:3000744 ! antibiotic sensitive dihydropteroate synthase synonym: "sul2" EXACT CARD_Short_Name [] [Term] id: ARO:3000413 name: sul3 namespace: antibiotic_resistance def: "Sul3 is a sulfonamide resistant dihydropteroate synthase similar to Sul1 and Sul2. Its resistance gene was found encoded in E. coli plasmid DNA of sulfonamide resistant isolates." [PMID:12604565] is_a: ARO:3004238 ! sulfonamide resistant sul relationship: confers_resistance_to_antibiotic ARO:3000324 ! sulfadiazine relationship: confers_resistance_to_antibiotic ARO:3000325 ! sulfadimidine relationship: confers_resistance_to_antibiotic ARO:3000327 ! sulfadoxine relationship: confers_resistance_to_antibiotic ARO:3000329 ! sulfamethoxazole relationship: confers_resistance_to_antibiotic ARO:3000330 ! sulfisoxazole relationship: confers_resistance_to_antibiotic ARO:3000683 ! sulfacetamide relationship: confers_resistance_to_antibiotic ARO:3000684 ! mafenide relationship: confers_resistance_to_antibiotic ARO:3000698 ! sulfasalazine relationship: confers_resistance_to_antibiotic ARO:3000699 ! sulfamethizole relationship: derives_from ARO:3000744 ! antibiotic sensitive dihydropteroate synthase synonym: "sul3" EXACT CARD_Short_Name [] [Term] id: ARO:3000419 name: quinolone resistance protein (qnr) namespace: antibiotic_resistance def: "Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics." [PMID:19822894, PMID:19258263, PMID:15933203] is_a: ARO:3000185 ! antibiotic target protection protein relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "Qnr" EXACT [] [Term] id: ARO:3000421 name: norB namespace: antibiotic_resistance def: "NorB is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 30% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. It is regulated by mgrA, also known as NorR." [PMID:15774883] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin synonym: "norB" EXACT CARD_Short_Name [] [Term] id: ARO:3000423 name: FomA namespace: antibiotic_resistance def: "In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic." [PMID:18701452, PMID:10681332] is_a: ARO:3004246 ! Fom phosphotransferase family relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FomA" EXACT CARD_Short_Name [] xref: PDB:3D40 [Term] id: ARO:3000443 name: rifampin glycosyltransferase namespace: antibiotic_resistance def: "The enzymatic inactivation of rifampin by glycosylation at the 23-OH position." [PMID:22802246, PMID:8328779] is_a: ARO:3000576 ! rifampin inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic relationship: participates_in ARO:3000208 ! glycosylation of antibiotic conferring resistance [Term] id: ARO:3000444 name: rphA namespace: antibiotic_resistance def: "The enzymatic inactivation of rifampin by phosphorylation at the 21-OH position." [PMID:27103605, PMID:7928806, PMID:24778229] is_a: ARO:3004040 ! rifampin phosphotransferase relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "rphA" EXACT CARD_Short_Name [] [Term] id: ARO:3000445 name: rifampin monooxygenase namespace: antibiotic_resistance def: "Enzyme responsible for the decolorization of rifampin by monoxygenation." [PMID:8980786, PMID:19942945] is_a: ARO:3000576 ! rifampin inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic relationship: participates_in ARO:3000450 ! hydroxylation of antibiotic conferring resistance [Term] id: ARO:3000446 name: antibiotic-resistant isoleucyl-tRNA synthetase (ileS) namespace: antibiotic_resistance def: "Mupirocin inhibits protein synthesis by interfering with isoleucyl-tRNA synthetase (ileS). Mutations in ileS can confer low-level mupirocin resistance." [PMID:21421794, PMID:11599741, PMID:11796355, PMID:8067768, PMID:22252810] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007151 ! mupirocin-like antibiotic relationship: derives_from ARO:3000732 ! antibiotic sensitive Isoleucyl-tRNA transferase [Term] id: ARO:3000448 name: QepA1 namespace: antibiotic_resistance def: "QepA1 is a plasmid-mediated efflux pump in E. coli, shown to contribute to fluoroquinolone resistance. It is regulated by sox genes, also known as global stress regulators." [PMID:17548499] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "QepA" EXACT [] synonym: "QepA1" EXACT CARD_Short_Name [] [Term] id: ARO:3000449 name: FomB namespace: antibiotic_resistance def: "An enzyme which on its own cannot provide fosfomycin resistance, however in conjunction with FomA, it leads to the formation of fosfomycin with three phosphates total, which makes it inactive." [PMID:18701452] is_a: ARO:3004246 ! Fom phosphotransferase family relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FomB" EXACT CARD_Short_Name [] [Term] id: ARO:3000450 name: hydroxylation of antibiotic conferring resistance namespace: antibiotic_resistance def: "Inactivation of an antibiotic via introduction a hydroxyl group (-OH)." [] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000451 name: protein(s) and two-component regulatory system modulating antibiotic efflux namespace: antibiotic_resistance def: "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux." [PMID:24878531, PMID:14572535] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:0010000 ! antibiotic efflux [Term] id: ARO:3000452 name: fluoroquinolone resistant DNA topoisomerase namespace: antibiotic_resistance def: "Fluoroquinolones inhibit type II and type IV topoisomerases (2 strand breaking enzymes) such as GyrA/GyrB and ParC/ParE. Point mutations in the associated gyrA and parC genes, in particular in the 'quinolone resistance determining region' (QRDR), give rise to resistance to the class." [PMID:11504468, PMID:20802486, PMID:22279180] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3000453 name: streptogramin vat acetyltransferase namespace: antibiotic_resistance def: "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds." [PMID:20713681, PMID:12771141, PMID:11841212] is_a: ARO:3000233 ! streptogramin inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic relationship: participates_in ARO:3000106 ! acylation of antibiotic conferring resistance synonym: "Streptogramin A acetyltransferase (SAT)" EXACT [] [Term] id: ARO:3000454 name: polymyxin B namespace: antibiotic_resistance def: "Polymyxin B is mixture of mostly polymyxins B1 and B2, mainly used for resistant gram-negative infections. They are polypeptides with cationic detergent action on cell membranes." [PMID:17201926] is_a: ARO:0000022 ! polymyxin antibiotic is_a: ARO:3000707 ! antibiotic mixture xref: pubchem.compound:49800004 [Term] id: ARO:3000455 name: streptogramin A biosynthesis namespace: antibiotic_resistance def: "Type A streptogramins are produced by a hybrid NRPS/PKS composed of 8 NRPS modules and 2 PKS modules." [] is_a: ARO:3000388 ! streptogramin biosynthesis [Term] id: ARO:3000456 name: thiamphenicol namespace: antibiotic_resistance def: "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3)." [PMID:15539072] is_a: ARO:3000387 ! phenicol antibiotic xref: pubchem.compound:27200 [Term] id: ARO:3000457 name: aminocoumarin resistant parE namespace: antibiotic_resistance def: "ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParE prevent anticoumarin antibiotics from inhibiting DNA synthesis, thus conferring resistance." [PMID:16127057] is_a: ARO:3000115 ! antibiotic resistant DNA topoisomerase subunit parE relationship: confers_resistance_to_drug_class ARO:3000103 ! aminocoumarin antibiotic relationship: derives_from ARO:3000023 ! aminocoumarin sensitive parE [Term] id: ARO:3000458 name: macrolide glycosyltransferase namespace: antibiotic_resistance def: "Macrolide glycosyltransferases are enzymes encoded by macrolide glycosyltransferase genes and inactivate macrolides by glycosylating them at 2'-OH of desosamine sugar moiety. They are predominantly found in macrolide producers and are also found in non-producers and are used as a resistance mechanism. Different variants of this enzyme has been reported." [PMID:17376874] is_a: ARO:3000201 ! macrolide inactivation enzyme relationship: participates_in ARO:3000208 ! glycosylation of antibiotic conferring resistance [Term] id: ARO:3000459 name: fosfomycin biosynthesis namespace: antibiotic_resistance def: "Biosynthesis of fosfomycin." [] is_a: ARO:3000082 ! antibiotic biosynthesis [Term] id: ARO:3000461 name: florfenicol namespace: antibiotic_resistance def: "Florfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis." [PMID:15539072] is_a: ARO:3000387 ! phenicol antibiotic xref: pubchem.compound:114811 [Term] id: ARO:3000462 name: mgtA namespace: antibiotic_resistance def: "A macrolide glycosyltransferase encoded by the mgtA gene in Streptomyces lividans. This enzyme inactivates macrolides using UDP-glucose as a cofactor. Its optimal substrates are lankamycin, calcomycin, rosaramicin, methymycin, and pikromycin, while interactions with erythomycin, oldeandomycin, azithromycin, and tylosin were weaker. It is inactive against spiramycin and carbomycin. Mechanism first described by Cundliffe, 1992." [PMID:1605601, PMID:1612452] is_a: ARO:3004237 ! mgt macrolide glycotransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3001232 ! methymycin synonym: "mgt" EXACT [] synonym: "mgtA" EXACT CARD_Short_Name [] [Term] id: ARO:3000463 name: gimA namespace: antibiotic_resistance def: "A macrolide glycosyltransferase encoded by the gimA gene in Streptomyces ambofaciens, a natural producer of the macrolide antibiotic spiramycin. Chalcomycin, methymycin, tylosin, pikromycin, rosaramicin, oleandomycin, josamycin, and carbomycin are preferred substrates of gimA glycosyltransferase, while erythromycin and spiramycin have notably low binding affinities. GimA may be able to inactivate spiramycin precursors. Described by Gourmelen et al. 1998." [PMID:9756764] is_a: ARO:3004236 ! gimA family macrolide glycosyltransferase relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin relationship: confers_resistance_to_antibiotic ARO:3001222 ! chalcomycin relationship: confers_resistance_to_antibiotic ARO:3001232 ! methymycin synonym: "gimA" EXACT CARD_Short_Name [] [Term] id: ARO:3000464 name: Neisseria gonorrhoeae porin PIB (por) namespace: antibiotic_resistance def: "Mutant forms of the porin Por result in reduced permeability to antibiotics, particularly tetracyclines and beta-lactams." [PMID:9797206, PMID:12183233, PMID:16547016] is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000054 ! penicillin synonym: "Ngon_porin" EXACT CARD_Short_Name [] [Term] id: ARO:3000465 name: ole glycosyltransferase namespace: antibiotic_resistance def: "OleI and OleD are glycosyltransferases found in Streptomyces antibioticus which is a natural producer of antibiotic oleandomycin. OleI glycosylates antibiotic oleandomycin whereas OleD can glycosylate a wide variety of macrolides." [PMID:17376874, PMID:9680207, PMID:15984838] is_a: ARO:3000458 ! macrolide glycosyltransferase relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic [Term] id: ARO:3000466 name: dalbavancin namespace: antibiotic_resistance def: "Dalbavancin is a semisynthetic second-generation lipoglycopeptide derived from teicoplanin. It binds to the D-Ala-D-Ala terminus of peptidoglycan precursors. It is used to treat Gram-positive bacteria and can be used to treat methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci." [PMID:27904526, PMID:17461743, PMID:15566329] is_a: ARO:3000081 ! glycopeptide antibiotic synonym: "Zeven" EXACT [] xref: pubchem.compound:23724878 [Term] id: ARO:3000467 name: NDM-5 namespace: antibiotic_resistance def: "New Delhi beta-lactamase NDM-5." [PMID:21930874] is_a: ARO:3000057 ! NDM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem synonym: "NDM-5" EXACT CARD_Short_Name [] [Term] id: ARO:3000469 name: hydroxypropylphosphonic acid epoxidase namespace: antibiotic_resistance def: "The enzyme responsible for the final step of fosfomycin biosynthesis. It converts S-2-hydroxypropylphosphonic acid (S-HPP) into fosfomycin via an oxidative cyclalization reaction. It uses Iron (II) or Zinc (II) as cofactors." [PMID:16186494, PMID:16015285] is_a: ARO:3000459 ! fosfomycin biosynthesis synonym: "Fom4" EXACT [] synonym: "HppE" EXACT [] xref: PDB:1ZZ6 [Term] id: ARO:3000476 name: tet(31) namespace: antibiotic_resistance def: "Tet31 is a tetracycline efflux pump found in Aeromonas salmonicida, a Gram-negative bacteria. It has also been shown to be expressed in Gallibacterium anatis." [PMID:11381101, PMID:12383729, PMID:21145184] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(31)" EXACT CARD_Short_Name [] synonym: "tet31" EXACT [] [Term] id: ARO:3000478 name: tet(33) namespace: antibiotic_resistance def: "Tet33 is a tetracycline efflux pump found in Gram-positive bacteria, including Arthrobacter and Corynebacterium." [PMID:12383729] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(33)" EXACT CARD_Short_Name [] synonym: "tet33" EXACT [] synonym: "tetA(33)" EXACT [] [Term] id: ARO:3000479 name: aminocoumarin resistant gyrB namespace: antibiotic_resistance def: "Point mutations in DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. These mutations usually involve arginine residues in organisms." [PMID:9797224, PMID:12604514, PMID:16868863, PMID:21693461, PMID:14993313, PMID:21996946] is_a: ARO:3000220 ! antibiotic resistant DNA topoisomerase subunit gyrB relationship: confers_resistance_to_drug_class ARO:3000103 ! aminocoumarin antibiotic relationship: derives_from ARO:3003260 ! aminocoumarin sensitive gyrB [Term] id: ARO:3000480 name: aminocoumarin resistant parY namespace: antibiotic_resistance def: "Expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can confer aminocoumarin resistance." [PMID:14993313, PMID:16868863, PMID:12604514] is_a: ARO:3000209 ! antibiotic resistant DNA topoisomerase subunit parY relationship: confers_resistance_to_drug_class ARO:3000103 ! aminocoumarin antibiotic relationship: derives_from ARO:3003253 ! aminocoumarin sensitive parY [Term] id: ARO:3000481 name: tet(35) namespace: antibiotic_resistance def: "Tet35 is a tetracycline efflux pump found in the Gram-negative Vibrio and Stenotrophomonas. It is unrelated to other tet resistance genes." [PMID:11897587] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "effJ" EXACT [] synonym: "tet(35)" EXACT CARD_Short_Name [] synonym: "tet35" EXACT [] [Term] id: ARO:3000488 name: telavancin namespace: antibiotic_resistance def: "Telavancin is a semi-synthetic derivative of vancomycin and is a second-generation lipoglycopeptide antibiotic. Telavancin inhibits cell wall synthesis by forming a complex with the D-Ala-D-Ala terminus of peptidoglycan precursors and preventing transglycosylation." [PMID:19401479, PMID:19436839, PMID:18671473] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:3081362 [Term] id: ARO:3000489 name: sav1866 namespace: antibiotic_resistance def: "Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil, tetraphenylphosphorchloride, and Hoechst 33342." [PMID:17303126, PMID:16943773] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics synonym: "sav1866" EXACT CARD_Short_Name [] xref: PDB:2HYD [Term] id: ARO:3000490 name: tuberactinomycin namespace: antibiotic_resistance def: "Tuberactinomycins are a family of cyclic peptide antibiotics that are important in the treatment of tuberculosis. Tuberactinomycins contain nonproteinogenic amino acids and inhibit group I self-splicing RNA to disrupt prokaryotic protein synthesis." [PMID:12936980, PMID:7509881] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:24847446 [Term] id: ARO:3000491 name: acrD namespace: antibiotic_resistance def: "AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR." [PMID:10692383] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic synonym: "acrD" EXACT CARD_Short_Name [] [Term] id: ARO:3000492 name: gene involved in self-resistance to antibiotic namespace: antibiotic_resistance def: "Genes that are involved in conferring self resistance to antibiotic." [PMID:16186494] is_a: ARO:3000000 ! determinant of antibiotic resistance [Term] id: ARO:3000495 name: ErmD namespace: antibiotic_resistance def: "ErmD confers MLSb phenotype." [PMID:26650381] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmD" EXACT CARD_Short_Name [] synonym: "ermJ" EXACT [] synonym: "ermK" EXACT [] [Term] id: ARO:3000496 name: vanXY namespace: antibiotic_resistance def: "VanXY is a protein with both D,D-carboxypeptidase and D,D-dipeptidase activity, found in Enterococcus gallinarum. It cleaves and removes the terminal D-Ala of peptidoglycan subunits for the incorporation of D-Ser by VanC. D-Ala-D-Ser has low binding affinity with vancomycin." [PMID:10564477] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000497 name: ethambutol namespace: antibiotic_resistance def: "Ethambutol is an antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin, and pyrazinamide. Ethambutol inhibits arabinosyl biosynthesis, disrupting mycobacterial cell wall formation." [PMID:18242089] is_a: ARO:3000527 ! polyamine antibiotic xref: pubchem.compound:14052 [Term] id: ARO:3000498 name: ErmF namespace: antibiotic_resistance def: "ErmF confers the MLSb phenotype." [PMID:26219215] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmF" EXACT CARD_Short_Name [] synonym: "ermFS" EXACT [] synonym: "ermFU" EXACT [] [Term] id: ARO:3000499 name: AcrE namespace: antibiotic_resistance def: "AcrE is a membrane fusion protein, similar to AcrA." [PMID:16267305, PMID:8407802] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000503 ! AcrEF-TolC relationship: part_of ARO:3004083 ! AcrEF-TolC confers resistance to ciprofloxacin synonym: "AcrE" EXACT CARD_Short_Name [] [Term] id: ARO:3000500 name: phosphonoacetaldehyde methyltransfererase namespace: antibiotic_resistance def: "The enzyme responsible for converting phosphonoacetaldehyde to (S)-2-/nhydroxypropylphosphonic acid (S-HPP) via an anionic methyl attack, which also reduces the aldehyde to an alcohol." [PMID:16015285, PMID:1468993] is_a: ARO:3000082 ! antibiotic biosynthesis synonym: "Fom3" EXACT [] [Term] id: ARO:3000501 name: rpoB2 namespace: antibiotic_resistance def: "Due to gene duplication, the genomes of Nocardia species include both rifampin-sensitive beta-subunit of RNA polymerase (rpoB) and rifampin-resistant beta-subunit of RNA polymerase (rpoB2) genes, with ~88% similarity between the two gene products. Expression of the rpoB2 variant results in replacement of rifampin sensitivity with rifampin resistance." [PMID:16569850] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "rpoB2" EXACT CARD_Short_Name [] [Term] id: ARO:3000502 name: AcrF namespace: antibiotic_resistance def: "AcrF is a inner membrane transporter, similar to AcrB." [PMID:16267305] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000503 ! AcrEF-TolC relationship: part_of ARO:3004083 ! AcrEF-TolC confers resistance to ciprofloxacin synonym: "AcrF" EXACT CARD_Short_Name [] [Term] id: ARO:3000503 name: AcrEF-TolC namespace: antibiotic_resistance def: "AcrEF-TolC is a tripartite multidrug efflux system similar to AcrAB-TolC and found in Gram-negative bacteria. AcrE is the membrane fusion protein, AcrF is the inner membrane transporter, and TolC is the outer membrane channel protein." [PMID:8647368, PMID:16267305, PMID:1720861, PMID:18984645, PMID:12937021] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam synonym: "EnvCD-TolC" EXACT [] [Term] id: ARO:3000504 name: golS namespace: antibiotic_resistance def: "GolS is a regulator activated by the presence of golD, and promotes the expression of the MdsABC efflux pump." [PMID:17919284, PMID:20807206] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000786 ! MdsABC synonym: "golS" EXACT CARD_Short_Name [] [Term] id: ARO:3000506 name: MexR namespace: antibiotic_resistance def: "MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM." [PMID:12727072, PMID:20616806, PMID:18812515, PMID:14526032] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004048 ! MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin relationship: part_of ARO:3004080 ! MexAB-OprM with MexR mutations confers resistance to multiple antibiotics relationship: regulates ARO:3000386 ! MexAB-OprM synonym: "MexR" EXACT CARD_Short_Name [] synonym: "nalB" EXACT [] xref: PDB:1LNW [Term] id: ARO:3000507 name: rifampin-resistant RNA polymerase-binding protein namespace: antibiotic_resistance def: "Proteins which have been experimentally shown to protect RNA-polymerase from rifampin inhibition." [] is_a: ARO:3000185 ! antibiotic target protection protein [Term] id: ARO:3000508 name: gadX namespace: antibiotic_resistance def: "GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance." [PMID:18297445] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000788 ! MdtEF-TolC relationship: regulates ARO:3003838 ! gadW synonym: "gadX" EXACT CARD_Short_Name [] [Term] id: ARO:3000510 name: Staphylococcus aureus mupB conferring resistance to mupirocin namespace: antibiotic_resistance def: "An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin." [PMID:22252810] is_a: ARO:3000446 ! antibiotic-resistant isoleucyl-tRNA synthetase (ileS) relationship: confers_resistance_to_antibiotic ARO:3000554 ! mupirocin synonym: "Saur_mupB_MUP" EXACT CARD_Short_Name [] [Term] id: ARO:3000515 name: evgSA namespace: antibiotic_resistance def: "EvgSA is a two-component regulatory system that regulates MdtEF and EmrKY expression for multidrug resistance. EvgS is a sensor protein that phosphorylates the regulatory protein EvgA, though EvgA can be phosphorylated by other methods when it is overexpressed." [PMID:11914367] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000373 ! EmrKY-TolC relationship: regulates ARO:3000788 ! MdtEF-TolC [Term] id: ARO:3000516 name: emrR namespace: antibiotic_resistance def: "EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression." [PMID:7730261] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000344 ! EmrAB-TolC synonym: "emrR" EXACT CARD_Short_Name [] synonym: "mprA" EXACT [] [Term] id: ARO:3000517 name: rifaximin namespace: antibiotic_resistance def: "Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase." [PMID:15667909] is_a: ARO:3000157 ! rifamycin antibiotic xref: pubchem.compound:6436173 [Term] id: ARO:3000518 name: CRP namespace: antibiotic_resistance def: "CRP is a global regulator that represses MdtEF multidrug efflux pump expression." [PMID:18503189] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000788 ! MdtEF-TolC synonym: "CRP" EXACT CARD_Short_Name [] [Term] id: ARO:3000519 name: antibiotic target modifying enzyme namespace: antibiotic_resistance def: "Enzymes that confer resistance by modifying antibiotic targets." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:0001001 ! antibiotic target alteration [Term] id: ARO:3000520 name: isoniazid namespace: antibiotic_resistance def: "Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria." [PMID:8143118, PMID:19139099] is_a: ARO:3007152 ! isoniazid-like antibiotic xref: pubchem.compound:3767 [Term] id: ARO:3000521 name: Staphylococcus aureus mupA conferring resistance to mupirocin namespace: antibiotic_resistance def: "An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin." [PMID:11599741, PMID:21421794, PMID:8067768] is_a: ARO:3000446 ! antibiotic-resistant isoleucyl-tRNA synthetase (ileS) relationship: confers_resistance_to_antibiotic ARO:3000554 ! mupirocin synonym: "Saur_mupA_MUP" EXACT CARD_Short_Name [] synonym: "ileS2" EXACT [] [Term] id: ARO:3000522 name: ErmG namespace: antibiotic_resistance def: "ErmG is a rRNA adenine N-6-methyltransferase that protects the ribosome from inactivation due to antibiotic binding." [PMID:3025178] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmG" EXACT CARD_Short_Name [] [Term] id: ARO:3000524 name: cpxAR namespace: antibiotic_resistance def: "CpxAR is a two-component regulatory system that involves a sensor kinase, CpxA, and the regulator CpxR. When the membrane envelope is stressed, CpxAR promotes acrD and mdtABC expression to confer multidrug resistance through efflux." [PMID:22496764, PMID:12618449] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000491 ! acrD relationship: regulates ARO:3000787 ! MdtABC-TolC relationship: regulates ARO:3004082 ! AcrAD-TolC [Term] id: ARO:3000525 name: antibiotic A40926 namespace: antibiotic_resistance def: "A40926 is a glycopeptide antibiotic produced by Nonomuraea sp. ATCC 39727. It is precusor of the second-generation glycopeptide antibiotic dalbavancin." [PMID:15664522, PMID:12837387] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:16133962 [Term] id: ARO:3000526 name: cmeR namespace: antibiotic_resistance def: "CmeR is a repressor for the CmeABC multidrug efflux pump, binding to the cmeABC promoter region." [PMID:15728904] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000773 ! CmeABC synonym: "cmeR" EXACT CARD_Short_Name [] [Term] id: ARO:3000527 name: polyamine antibiotic namespace: antibiotic_resistance def: "Polyamine antibiotics are organic compounds having two or more primary amino groups." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000528 name: chlortetracycline namespace: antibiotic_resistance def: "Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome." [PMID:11381101, PMID:19862477] is_a: ARO:3000050 ! tetracycline antibiotic synonym: "Aureomycin" EXACT [] synonym: "Eremomycine" EXACT [] xref: pubchem.compound:54675777 [Term] id: ARO:3000530 name: rifabutin namespace: antibiotic_resistance def: "Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis." [PMID:15700959] is_a: ARO:3000157 ! rifamycin antibiotic xref: pubchem.compound:135398743 [Term] id: ARO:3000531 name: baeSR namespace: antibiotic_resistance def: "BaeSR is a two component regulatory system for efflux proteins in Gram-negative bacteria. BaeR is a response regulator, while BaeS is a sensor kinase." [PMID:12107134, PMID:15716448] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000491 ! acrD relationship: regulates ARO:3000787 ! MdtABC-TolC relationship: regulates ARO:3004082 ! AcrAD-TolC [Term] id: ARO:3000532 name: aminocoumarin biosynthesis namespace: antibiotic_resistance def: "Biosynthesis of aminocoumarin antibiotics." [PMID:16868863] is_a: ARO:3000082 ! antibiotic biosynthesis [Term] id: ARO:3000533 name: macA namespace: antibiotic_resistance def: "MacA is a membrane fusion protein that forms an antibiotic efflux complex with MacB and TolC. macA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58." [PMID:19254725, PMID:20307498] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000545 ! MacAB-TolC synonym: "macA" EXACT CARD_Short_Name [] synonym: "pvdR" EXACT [] xref: PDB:3FPP [Term] id: ARO:3000534 name: rifapentine namespace: antibiotic_resistance def: "Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy." [PMID:15700959] is_a: ARO:3000157 ! rifamycin antibiotic synonym: "priftin" EXACT [] xref: pubchem.compound:135403821 [Term] id: ARO:3000535 name: macB namespace: antibiotic_resistance def: "MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC. macB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58." [PMID:19432486, PMID:12832048, PMID:16359323] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000545 ! MacAB-TolC synonym: "macB" EXACT CARD_Short_Name [] synonym: "pvdT" EXACT [] xref: PDB:3FTJ [Term] id: ARO:3000536 name: Streptomyces spheroides novobiocin biosynthetic gene cluster namespace: antibiotic_resistance def: "Novobiocin is produced from biosynthetic clusters in Streptomyces spheroides and Streptomyces niveus." [PMID:10801869, PMID:10770754] is_a: ARO:3000532 ! aminocoumarin biosynthesis [Term] id: ARO:3000545 name: MacAB-TolC namespace: antibiotic_resistance def: "MacAB-TolC is an ABC efflux pump complex expressed in E. coli and Salmonella enterica. It confers resistance to macrolides, including erythromycin." [PMID:16359323] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin [Term] id: ARO:3000546 name: Streptomyces roseochromogenus subsp. oscitans clorobiocin biosynthetic gene cluster namespace: antibiotic_resistance def: "Clorobiocin is produced by a biosynthetic cluster in Streptomyces roseochromogenus subsp. oscitans." [PMID:12480894, PMID:16868863] is_a: ARO:3000532 ! aminocoumarin biosynthesis [Term] id: ARO:3000547 name: arlRS namespace: antibiotic_resistance def: "ArlRS is a two-component regulatory system for NorA. ArlS phosphorylates ArlR to promote NorA expression." [PMID:10633099] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000391 ! norA [Term] id: ARO:3000548 name: Streptomyces rishiriensis strain DSM 40489 coumermycin A1 biosynthetic gene cluster namespace: antibiotic_resistance def: "Coumermycin A1 is produced by a biosynthetic cluster in Streptomyces rishiriensis." [PMID:11036020, PMID:16868863] is_a: ARO:3000532 ! aminocoumarin biosynthesis [Term] id: ARO:3000549 name: adeS namespace: antibiotic_resistance def: "AdeS is a sensor kinase in the AdeRS regulatory system of AdeABC. It is essential for AdeABC expression." [PMID:22371895] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000770 ! AdeABC synonym: "adeS" EXACT CARD_Short_Name [] [Term] id: ARO:3000550 name: aztreonam namespace: antibiotic_resistance def: "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death." [PMID:3871589] is_a: ARO:0000004 ! monobactam synonym: "ATM" EXACT [] synonym: "Primbactam" EXACT [] xref: pubchem.compound:5742832 [Term] id: ARO:3000551 name: organoarsenic antibiotic namespace: antibiotic_resistance def: "Organoarsenic antibiotics are arsenic-containing compounds with antibacterial effects. The organoarsenic antibiotic arsphenamine and its derivatives were developed in the 1910s as the first modern chemotherapeutic agents." [] is_a: ARO:1000003 ! antibiotic molecule synonym: "Salvarsan" EXACT [] synonym: "arsenical" EXACT [] [Term] id: ARO:3000552 name: arsphenamine namespace: antibiotic_resistance def: "Arsphenamine, also known as Salvarsan and 606, is a drug that was used beginning in the 1910s to treat syphilis and trypanosomiasis. It is an organoarsenic compound and was the first modern chemotherapeutic agent." [PMID:18679046] is_a: ARO:3000551 ! organoarsenic antibiotic synonym: "Salvarsan" EXACT [] xref: pubchem.compound:8774 [Term] id: ARO:3000553 name: adeR namespace: antibiotic_resistance def: "AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics." [PMID:22371895] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000770 ! AdeABC synonym: "adeR" EXACT CARD_Short_Name [] [Term] id: ARO:3000554 name: mupirocin namespace: antibiotic_resistance def: "Mupirocin, also known as pseudomonic acid, is a bacteriostatic polyketide antibiotic from Pseudomonas fluorescens used to treat S. aureus and MRSA. It inhibits Ile tRNA synthetase." [PMID:21336932] is_a: ARO:3007151 ! mupirocin-like antibiotic synonym: "pseudomonic acid" EXACT [] xref: pubchem.compound:446596 [Term] id: ARO:3000555 name: macrolide biosynthesis namespace: antibiotic_resistance def: "Biosynthesis of macrolide antibiotics." [] is_a: ARO:3000082 ! antibiotic biosynthesis [Term] id: ARO:3000556 name: tet(44) namespace: antibiotic_resistance def: "Tet44 is a tetracycline resistance gene found in Campylobacter fetus, and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein." [PMID:20479200] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(44)" EXACT CARD_Short_Name [] [Term] id: ARO:3000557 name: antibiotic inactivation enzyme namespace: antibiotic_resistance def: "Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3000559 name: adeN namespace: antibiotic_resistance def: "AdeN is a repressor of AdeIJK, a RND-type efflux pump in Acinetobacter baumannii. Its inactivation increases expression of AdeJ." [PMID:22371895] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000772 ! AdeIJK synonym: "adeN" EXACT CARD_Short_Name [] [Term] id: ARO:3000560 name: Erm 23S ribosomal RNA methyltransferase namespace: antibiotic_resistance def: "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype." [PMID:20618865, PMID:10582867] is_a: ARO:3004274 ! 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic [Term] id: ARO:3000561 name: tet(30) namespace: antibiotic_resistance def: "Tet30 is a tetracycline efflux pump found in agrobacterium, a Gram-negative bacterium." [PMID:11381101, PMID:9882678] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(30)" EXACT CARD_Short_Name [] synonym: "tet30" EXACT [] [Term] id: ARO:3000565 name: tet(38) namespace: antibiotic_resistance def: "Tet38 is a tetracycline efflux pump found in the Gram-positive Staphylococcus aureus. It is regulated by mgrA, which also regulates NorB." [PMID:15774883] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(38)" EXACT CARD_Short_Name [] synonym: "tet38" EXACT [] [Term] id: ARO:3000566 name: tet(39) namespace: antibiotic_resistance def: "Tet39 is a tetracycline efflux pump found in Gram-negative bacteria, including Brevundimonas, Stenotrophomonas, Enterobacter, Alcaligenes, Acinetobacter, and Providencia." [PMID:15761075] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(39)" EXACT CARD_Short_Name [] synonym: "tet39" EXACT [] synonym: "tetA(39)" EXACT [] [Term] id: ARO:3000567 name: tet(40) namespace: antibiotic_resistance def: "Tet40 is a tetracycline efflux pump found in the Gram-positive Clostridium. It is similar to tetA(P)." [PMID:18779355] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(40)" EXACT CARD_Short_Name [] synonym: "tet40" EXACT [] [Term] id: ARO:3000568 name: subclass B1 (metallo-) beta-lactamase namespace: antibiotic_resistance def: "Subclass B1 possess a binuclear active site. Within this active site can be either one or two Zn(II) ions. This subclass is able to hydrolyze penicillins, cephalosporins and carbapenems. This is the most clinically relevant subclass of MBLs." [PMID:18563261] is_a: ARO:3000004 ! class B (metallo-) beta-lactamase [Term] id: ARO:3000569 name: tet(41) namespace: antibiotic_resistance def: "Tet41 is a tetracycline efflux pump found in Serratia, a Gram-negative bacterium. It is related to Acinetobacter Tet(39)." [PMID:17308196] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(41)" EXACT CARD_Short_Name [] synonym: "tet41" EXACT [] synonym: "tetA(41)" EXACT [] [Term] id: ARO:3000570 name: subclass B2 (metallo-) beta-lactamase namespace: antibiotic_resistance def: "Metallo-beta-lactmases of subclass B2 contain only one Zn ion in their active site and selectively hydrolyze carbapenems." [] is_a: ARO:3000004 ! class B (metallo-) beta-lactamase [Term] id: ARO:3000571 name: subclass B3 (metallo-) beta-lactamase namespace: antibiotic_resistance def: "Metallo-beta-lactamases of subclass B3 are similar to B1 in that they have activity against penicillins, cephalosporins and carbapenems; however, the are only active with two Zn(II) ions in the active site." [PMID:18563261] is_a: ARO:3000004 ! class B (metallo-) beta-lactamase [Term] id: ARO:3000572 name: tet(42) namespace: antibiotic_resistance def: "Tet42 is a tetracycline efflux pump found in both Gram-negative (Pseudomonas) and Gram-positive (Microbacterium, Bacillus, Staphylococcus, Paenibacillus) bacteria." [PMID:18809935] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(42)" EXACT CARD_Short_Name [] synonym: "tet42" EXACT [] synonym: "tetA(42)" EXACT [] [Term] id: ARO:3000573 name: tet(43) namespace: antibiotic_resistance def: "Tet(43) is a tetracycline resistance gene with unknown origins, isolated from metagenomic DNA." [PMID:11381101] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(43)" EXACT CARD_Short_Name [] synonym: "tet43" EXACT [] [Term] id: ARO:3000574 name: vanR namespace: antibiotic_resistance def: "VanR is a OmpR-family transcriptional activator in the VanSR regulatory system. When activated by VanS, it promotes cotranscription of VanA, VanH, and VanX." [PMID:1556077] is_a: ARO:3002905 ! VanS-VanR two-component regulatory system relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000575 name: vanU namespace: antibiotic_resistance def: "VanU is a transcriptional activator of vancomycin resistance genes." [PMID:11036060, PMID:14617152] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3000576 name: rifampin inactivation enzyme namespace: antibiotic_resistance def: "Enzymes that inactivate rifampin antibiotics by chemical modification." [] is_a: ARO:3000557 ! antibiotic inactivation enzyme [Term] id: ARO:3000577 name: subclass B1 Bacillus cereus Bc beta-lactamase namespace: antibiotic_resistance def: "Subclass B1 Bacillus cereus Bc beta-lactamases are zinc metallo-beta-lactamases that hydrolyze a large number of penicillins and cephalosporins." [PMID:7588620] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000578 name: CcrA namespace: antibiotic_resistance def: "CcrA is a CfiA beta-lactamase." [PMID:1510410] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CciA" EXACT [] synonym: "CcrA" EXACT CARD_Short_Name [] [Term] id: ARO:3000579 name: Chryseobacterium meningosepticum BlaB namespace: antibiotic_resistance def: "This BlaB specific to Chryseobacterium meningosepticum mediates resistance against many beta-lactam antibiotics, notably penams and carbapenems." [PMID:12019109] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "Cmen_BlaB" EXACT CARD_Short_Name [] [Term] id: ARO:3000580 name: SPM beta-lactamase namespace: antibiotic_resistance def: "Sao Paulo metallo-beta-lactamase (SPM-1) confers resistance to carbapenem in Pseudomonas aeruginosa." [PMID:12951331, PMID:16239284, PMID:12407123] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3000581 name: CphA beta-lactamase namespace: antibiotic_resistance def: "CphA is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophilia. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein." [PMID:18563261] is_a: ARO:3000570 ! subclass B2 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3000582 name: L1 beta-lactamase namespace: antibiotic_resistance def: "L1 is an Ambler class B MBL; subclass B3 originally isolated from Stenotrophomonas maltophilia. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site." [PMID:18563261] is_a: ARO:3004215 ! L1 family beta-lactamase synonym: "L1_BLA" EXACT CARD_Short_Name [] xref: PDB:2QDT [Term] id: ARO:3000583 name: pristinamycin IA namespace: antibiotic_resistance def: "Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains." [] is_a: ARO:0000050 ! streptogramin B antibiotic synonym: "Virginiamycin B" EXACT [] xref: pubchem.compound:11136668 [Term] id: ARO:3000584 name: quinupristin namespace: antibiotic_resistance def: "Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis." [PMID:9746015, PMID:15700955] is_a: ARO:0000050 ! streptogramin B antibiotic xref: pubchem.compound:5388937 [Term] id: ARO:3000586 name: pulvomycin namespace: antibiotic_resistance def: "Pulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance." [PMID:16734421, PMID:7957075, PMID:15581367, PMID:364475] is_a: ARO:3001219 ! elfamycin antibiotic synonym: "Labilomycin" EXACT [] xref: pubchem.compound:5282056 [Term] id: ARO:3000587 name: sulbactam namespace: antibiotic_resistance def: "Sulbactam is an inhibitor of non-AmpC serine beta-lactamases." [] is_a: ARO:3007130 ! beta-lactam derived beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000875 ! TEM-3 relationship: is_small_molecule_inhibitor ARO:3000881 ! TEM-9 relationship: is_small_molecule_inhibitor ARO:3000882 ! TEM-10 relationship: is_small_molecule_inhibitor ARO:3000896 ! TEM-26 relationship: is_small_molecule_inhibitor ARO:3001397 ! OXA-2 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 xref: pubchem.compound:130313 [Term] id: ARO:3000588 name: avibactam namespace: antibiotic_resistance def: "Serine beta-lactamase inhibitor targeting class A, class C, and some class D enzymes." [PMID:20921316, PMID:27528799, PMID:27480848] is_a: ARO:3007008 ! diazabicyclooctane relationship: is_small_molecule_inhibitor ARO:3000873 ! TEM-1 relationship: is_small_molecule_inhibitor ARO:3000875 ! TEM-3 relationship: is_small_molecule_inhibitor ARO:3000881 ! TEM-9 relationship: is_small_molecule_inhibitor ARO:3000882 ! TEM-10 relationship: is_small_molecule_inhibitor ARO:3000884 ! TEM-12 relationship: is_small_molecule_inhibitor ARO:3000896 ! TEM-26 relationship: is_small_molecule_inhibitor ARO:3000898 ! TEM-28 relationship: is_small_molecule_inhibitor ARO:3000937 ! TEM-71 relationship: is_small_molecule_inhibitor ARO:3001059 ! SHV-1 relationship: is_small_molecule_inhibitor ARO:3001060 ! SHV-2 relationship: is_small_molecule_inhibitor ARO:3001062 ! SHV-3 relationship: is_small_molecule_inhibitor ARO:3001063 ! SHV-4 relationship: is_small_molecule_inhibitor ARO:3001066 ! SHV-7 relationship: is_small_molecule_inhibitor ARO:3001076 ! SHV-18 relationship: is_small_molecule_inhibitor ARO:3001109 ! SHV-52 relationship: is_small_molecule_inhibitor ARO:3001396 ! OXA-1 relationship: is_small_molecule_inhibitor ARO:3001821 ! ACT-1 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3001886 ! CTX-M-24 relationship: is_small_molecule_inhibitor ARO:3001889 ! CTX-M-27 relationship: is_small_molecule_inhibitor ARO:3001917 ! CTX-M-55 relationship: is_small_molecule_inhibitor ARO:3001926 ! CTX-M-65 relationship: is_small_molecule_inhibitor ARO:3002019 ! CMY-8 relationship: is_small_molecule_inhibitor ARO:3002182 ! MOX-1 relationship: is_small_molecule_inhibitor ARO:3002195 ! IMP-4 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 relationship: is_small_molecule_inhibitor ARO:3002313 ! KPC-3 relationship: is_small_molecule_inhibitor ARO:3007180 ! MAB synonym: "NXL-104" EXACT [] xref: pubchem.compound:24944097 [Term] id: ARO:3000589 name: NDM-1 namespace: antibiotic_resistance def: "NDM-1 is a metallo-beta-lactamase isolated from Klebsiella pneumoniae with nearly complete resistance to all beta-lactam antibiotics." [PMID:21507902, PMID:27575913, PMID:21774017, PMID:19770275, PMID:29454953, PMID:24790993] is_a: ARO:3000057 ! NDM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem synonym: "NDM-1" EXACT CARD_Short_Name [] xref: PDB:5ZGE [Term] id: ARO:3000590 name: NDM-2 namespace: antibiotic_resistance def: "NDM-2 was isolated from a strain of Acinetobacter baumannii in Germany from a patient hospitalized in Cairo. A single amino acid substitution (P28R) differentiates this gene from NDM-1 and the two enzymes appear to have an identical spectrum of hydrolysis." [PMID:21427107] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3000592 name: ErmN namespace: antibiotic_resistance def: "ErmN is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the tylosin biosynthetic cluster and is responsible for self-resistance to tylosin." [PMID:12417742, PMID:12019067, PMID:8973363] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmN" EXACT CARD_Short_Name [] synonym: "tlrD" EXACT [] [Term] id: ARO:3000593 name: ErmQ namespace: antibiotic_resistance def: "ErmQ confers MLSb phenotype." [PMID:8067735] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmQ" EXACT CARD_Short_Name [] [Term] id: ARO:3000594 name: ErmR namespace: antibiotic_resistance def: "ErmR is a methyltransferase found in the erythromycin producer Aeromicrobium erythreum. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance." [PMID:1768148] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmR" EXACT CARD_Short_Name [] [Term] id: ARO:3000595 name: ErmT namespace: antibiotic_resistance def: "ErmT confers MLSb phenotype." [PMID:8171126] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmT" EXACT CARD_Short_Name [] synonym: "ermGT" EXACT [] [Term] id: ARO:3000596 name: ErmX namespace: antibiotic_resistance def: "ErmX is a rRNA methyltransferase that protects the ribosome from inactivation due to antibiotic binding." [PMID:11408212] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmX" EXACT CARD_Short_Name [] synonym: "ermCD" EXACT [] synonym: "ermCX" EXACT [] [Term] id: ARO:3000598 name: Erm(31) namespace: antibiotic_resistance def: "Erm(31) confers a MLSb resistant phenotype. Along with erm(30), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae." [PMID:9770448, PMID:14674753] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:3001226 ! narbomycin relationship: confers_resistance_to_antibiotic ARO:3001232 ! methymycin relationship: confers_resistance_to_antibiotic ARO:3001233 ! pikromycin synonym: "Erm(31)" EXACT CARD_Short_Name [] synonym: "Erm31" EXACT [] [Term] id: ARO:3000599 name: Erm(33) namespace: antibiotic_resistance def: "ErmD confers MLSb phenotype." [PMID:12384375] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "Erm(33)" EXACT CARD_Short_Name [] synonym: "Erm33" EXACT [] [Term] id: ARO:3000600 name: Erm(34) namespace: antibiotic_resistance def: "ErmD confers MLSb phenotype." [PMID:14711653] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "Erm(34)" EXACT CARD_Short_Name [] synonym: "Erm34" EXACT [] [Term] id: ARO:3000601 name: Erm(38) namespace: antibiotic_resistance def: "ErmD confers MLSb phenotype." [PMID:16127056] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "Erm(38)" EXACT CARD_Short_Name [] synonym: "Erm38" EXACT [] [Term] id: ARO:3000602 name: Erm(39) namespace: antibiotic_resistance def: "ErmD confers MLSb phenotype." [PMID:15590712] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "Erm(39)" EXACT CARD_Short_Name [] synonym: "Erm39" EXACT [] [Term] id: ARO:3000603 name: Erm(41) namespace: antibiotic_resistance def: "Erm41 confers MLSb phenotype." [PMID:27244062] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "Erm(41)" EXACT CARD_Short_Name [] synonym: "Erm41" EXACT [] [Term] id: ARO:3000604 name: Erm(35) namespace: antibiotic_resistance def: "ErmD confers MLSb phenotype." [PMID:1804017] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "Erm(35)" EXACT CARD_Short_Name [] synonym: "Erm35" EXACT [] [Term] id: ARO:3000605 name: Erm(36) namespace: antibiotic_resistance def: "ErmD confers MLSb phenotype." [PMID:12177341] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000176 ! dirithromycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "Erm(36)" EXACT CARD_Short_Name [] synonym: "Erm36" EXACT [] [Term] id: ARO:3000606 name: FEZ-1 namespace: antibiotic_resistance def: "FEZ-1 is an Ambler class B MBL; subclass B3 first isolated from Legionella gormanii. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site." [PMID:18563261, PMID:12507470] is_a: ARO:3004211 ! FEZ beta-lactamase synonym: "FEZ-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000610 name: gene detected by antibiotic resistance screening microarray namespace: antibiotic_resistance def: "Many genes involved in antibiotic resistance are mobile and microarray probes for these genes can thus provide positive results for any number of organisms. CARD stores the coding sequences of genes targeted by the probe sets of available antibiotic resistance microarrays." [PMID:20035807, PMID:20356716] is_a: ARO:3000000 ! determinant of antibiotic resistance [Term] id: ARO:3000614 name: mef(E) namespace: antibiotic_resistance def: "mef(E) is a proton motive efflux pump in Streptococcus pneumoniae that confers resistance to macrolides. It is found on the same operon as mefA and the ABC-efflux pump mel." [PMID:16189099] is_a: ARO:3000747 ! mef relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "mef(E)" EXACT CARD_Short_Name [] synonym: "mefE" EXACT [] [Term] id: ARO:3000616 name: mel namespace: antibiotic_resistance def: "Mel, a homolog of MsrA, is an ABC-F subfamily protein associated with macrolide resistance. It is expressed on the same operon as mefA and mefE, both MFS-type efflux proteins that confer macrolide resistance." [PMID:16189099, PMID:23114767, PMID:22137270] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin synonym: "mefA" EXACT [] synonym: "mel" EXACT CARD_Short_Name [] synonym: "msr(D)" EXACT [] synonym: "msrD" EXACT [] [Term] id: ARO:3000617 name: mecA namespace: antibiotic_resistance def: "A foreign PBP2a acquired by lateral gene transfer that is able to perform peptidoglycan synthesis in the presence of beta-lactams." [PMID:18718557, PMID:12389036, PMID:6563036, PMID:21636525, PMID:2708325, PMID:27547406, PMID:15226303, PMID:3878127, PMID:21931689] is_a: ARO:3001208 ! methicillin resistant PBP2 relationship: confers_resistance_to_antibiotic ARO:0000015 ! methicillin synonym: "PBP2A" EXACT [] synonym: "mecA" EXACT CARD_Short_Name [] [Term] id: ARO:3000619 name: fluoroquinolone resistant parC namespace: antibiotic_resistance def: "ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations." [PMID:18471102, PMID:9293187, PMID:8913454] is_a: ARO:3000274 ! antibiotic resistant DNA topoisomerase subunit parC is_a: ARO:3000452 ! fluoroquinolone resistant DNA topoisomerase relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: derives_from ARO:3000735 ! Fluoroquinolone sensitive parC [Term] id: ARO:3000620 name: adeL namespace: antibiotic_resistance def: "AdeL is a regulator of AdeFGH in Acinetobacter baumannii. AdeL mutations are associated with AdeFGH overexpression and multidrug resistance." [PMID:20696879] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000771 ! AdeFGH synonym: "adeL" EXACT CARD_Short_Name [] [Term] id: ARO:3000621 name: PC1 beta-lactamase (blaZ) namespace: antibiotic_resistance def: "The blaZ beta-lactamase is found in Bacillus subtilis and Staphylococcus aureus." [PMID:6793593, PMID:17986343] is_a: ARO:3004197 ! BlaZ beta-lactamase relationship: part_of ARO:3000262 ! bla operon synonym: "PC1_blaZ" EXACT CARD_Short_Name [] xref: PDB:3BLM [Term] id: ARO:3000622 name: colistin A namespace: antibiotic_resistance def: "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria." [PMID:19157746, PMID:20818945] is_a: ARO:0000022 ! polymyxin antibiotic is_a: ARO:0000067 ! colistin synonym: "polymyxin E1" EXACT [] xref: pubchem.compound:202195 [Term] id: ARO:3000624 name: colistin B namespace: antibiotic_resistance def: "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria." [PMID:19157746, PMID:20818945] is_a: ARO:0000022 ! polymyxin antibiotic is_a: ARO:0000067 ! colistin synonym: "polymyxin E2" EXACT [] xref: pubchem.compound:25138298 [Term] id: ARO:3000625 name: polymyxin B1 namespace: antibiotic_resistance def: "Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria." [PMID:11330807] is_a: ARO:0000022 ! polymyxin antibiotic is_a: ARO:3000454 ! polymyxin B xref: pubchem.compound:199402 [Term] id: ARO:3000626 name: polymyxin B2 namespace: antibiotic_resistance def: "Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria." [PMID:11330807] is_a: ARO:0000022 ! polymyxin antibiotic is_a: ARO:3000454 ! polymyxin B xref: pubchem.compound:11982455 [Term] id: ARO:3000627 name: polymyxin B3 namespace: antibiotic_resistance def: "Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria." [PMID:11330807] is_a: ARO:0000022 ! polymyxin antibiotic is_a: ARO:3000454 ! polymyxin B xref: pubchem.compound:46883542 [Term] id: ARO:3000628 name: polymyxin B4 namespace: antibiotic_resistance def: "Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria." [PMID:11330807] is_a: ARO:0000022 ! polymyxin antibiotic is_a: ARO:3000454 ! polymyxin B xref: pubchem.compound:46883543 [Term] id: ARO:3000629 name: bacitracin A namespace: antibiotic_resistance def: "Bacitracin A is the primary component of bacitracin. It contains many uncommon amino acids and interferes with bacterial cell wall synthesis." [PMID:6752975] is_a: ARO:0000041 ! bacitracin xref: pubchem.compound:10909430 [Term] id: ARO:3000630 name: bacitracin B namespace: antibiotic_resistance def: "Bacitracin B is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It differs from Bacitracin A with a valine instead of an isoleucine in its peptide." [PMID:6752975] is_a: ARO:0000041 ! bacitracin xref: pubchem.compound:121232829 [Term] id: ARO:3000631 name: bacitracin F namespace: antibiotic_resistance def: "Bacitracin F is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It is formed when the thiazoline ring of bacitracin A is oxidatively deaminated." [PMID:6752975] is_a: ARO:0000041 ! bacitracin xref: pubchem.compound:3082210 [Term] id: ARO:3000632 name: benzylpenicillin namespace: antibiotic_resistance def: "Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid." [PMID:4610013] is_a: ARO:3000008 ! penam synonym: "Penicillin G" EXACT [] synonym: "benzopenicillin" EXACT [] xref: pubchem.compound:5904 [Term] id: ARO:3000633 name: phenoxymethylpenicillin namespace: antibiotic_resistance def: "Phenoxymethylpenicillin, or penicillin V, is a penicillin derivative that is acid stable but less active than benzylpenicillin (penicillin G)." [PMID:3924086] is_a: ARO:3000008 ! penam synonym: "penicillin V" EXACT [] synonym: "phenomycilline" EXACT [] synonym: "phenopenicillin" EXACT [] xref: pubchem.compound:6869 [Term] id: ARO:3000634 name: propicillin namespace: antibiotic_resistance def: "Propicillin is an orally taken penicillin derivative that has high absorption but poor activity." [PMID:3588519, PMID:14056922] is_a: ARO:3000008 ! penam synonym: "levopropicillin" EXACT [] xref: pubchem.compound:92879 [Term] id: ARO:3000635 name: dicloxacillin namespace: antibiotic_resistance def: "Dicloxacillin is a penicillin derivative that has an extra chlorine atom in comparison to cloxacillin. While more active than cloxacillin, its high affinity for serum protein reduces its activity in human serum in vitro." [PMID:3764352, PMID:3588519] is_a: ARO:3000008 ! penam synonym: "dicloxacilin" EXACT [] synonym: "dicloxacycline" EXACT [] xref: pubchem.compound:18381 [Term] id: ARO:3000636 name: flucloxacillin namespace: antibiotic_resistance def: "Flucloxacillin is similar to cloxacillin, with an extra additional fluorine atom." [PMID:3588519] is_a: ARO:3000008 ! penam synonym: "floxacillin" EXACT [] synonym: "floxapen" EXACT [] xref: pubchem.compound:21319 [Term] id: ARO:3000637 name: ampicillin namespace: antibiotic_resistance def: "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin." [PMID:3224398, PMID:44765] is_a: ARO:3000008 ! penam synonym: "AMP" EXACT [] synonym: "Principen" EXACT [] synonym: "ampicillin acid" EXACT [] xref: pubchem.compound:6249 [Term] id: ARO:3000638 name: azlocillin namespace: antibiotic_resistance def: "Azlocillin is a semisynthetic derivative of penicillin that is notably active against Ps. aeruginosa and other Gram-negative bacteria." [PMID:6369480] is_a: ARO:3000008 ! penam synonym: "AZL" EXACT [] xref: pubchem.compound:6479523 [Term] id: ARO:3000639 name: mezlocillin namespace: antibiotic_resistance def: "Mezlocillin is a penicillin derivative taken parenterally." [PMID:6369480] is_a: ARO:3000008 ! penam synonym: "mezlin" EXACT [] xref: pubchem.compound:656511 [Term] id: ARO:3000640 name: doripenem namespace: antibiotic_resistance def: "Doripenem is a carbapenem with a broad range of activity against Gram-positive and Gram-negative bacteria, and along with meropenem, it is the most active beta-lactam antibiotic against Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis." [PMID:16307551, PMID:15047550] is_a: ARO:0000020 ! carbapenem synonym: "doribax" EXACT [] xref: pubchem.compound:73303 [Term] id: ARO:3000641 name: cefalexin namespace: antibiotic_resistance def: "Cefalexin is a cephalosporin antibiotic that causes filamentation. It is resistant to staphylococcal beta-lactamase, but degraded by enterobacterial beta-lactamases." [PMID:4559812] is_a: ARO:0000032 ! cephalosporin synonym: "LEX" EXACT [] synonym: "cephalexin" EXACT [] xref: pubchem.compound:27447 [Term] id: ARO:3000642 name: cefadroxil namespace: antibiotic_resistance def: "Cefadroxil, or p-hydroxycephalexin, is an cephalosporin antibiotic similar to cefalexin." [PMID:3542485] is_a: ARO:0000032 ! cephalosporin synonym: "CFR" EXACT [] synonym: "p-hydroxycephalexin" EXACT [] xref: pubchem.compound:47965 [Term] id: ARO:3000643 name: cefotiam namespace: antibiotic_resistance def: "Cefotiam is a cephalosporin antibiotic with similar activity to cefuroxime but more active against enterobacteria. It is consumed orally as the prodrug cefotiam hexetil." [PMID:18611654] is_a: ARO:0000032 ! cephalosporin synonym: "cefotiamum" EXACT [] xref: pubchem.compound:43708 [Term] id: ARO:3000644 name: cefaclor namespace: antibiotic_resistance def: "Cefaclor is a semisynthetic cephalosporin derived from cephalexin. It has broad-spectrum antibiotic activity." [PMID:10435677] is_a: ARO:0000032 ! cephalosporin synonym: "CEC" EXACT [] synonym: "ceclor" EXACT [] synonym: "cephaclor" EXACT [] xref: pubchem.compound:51039 [Term] id: ARO:3000645 name: cefotaxime namespace: antibiotic_resistance def: "Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups." [PMID:2083516] is_a: ARO:0000032 ! cephalosporin synonym: "CTX" EXACT [] synonym: "cefotaxime acid" EXACT [] xref: pubchem.compound:5742673 [Term] id: ARO:3000646 name: cefixime namespace: antibiotic_resistance def: "Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor." [PMID:2684593] is_a: ARO:0000032 ! cephalosporin synonym: "CFM" EXACT [] synonym: "necopen" EXACT [] xref: pubchem.compound:5362065 [Term] id: ARO:3000647 name: cefpodoxime namespace: antibiotic_resistance def: "Cefpodoxime is a semisynthetic cephalosporin that acts similarly to cefotaxime with broad-spectrum activity. It is stable to many plasmid-mediated beta-lactamses. Cefpodoxime is consumed as the prodrug cefpodoxime proxetil." [PMID:18611588, PMID:1280571] is_a: ARO:0000032 ! cephalosporin synonym: "CPD" EXACT [] xref: pubchem.compound:6335986 [Term] id: ARO:3000648 name: ceftibuten namespace: antibiotic_resistance def: "Ceftibuten is a semisynthetic cephalosporin active against Gram-negative bacilli. It is resistant against many plasmid-mediated beta-lactamases." [PMID:9296244, PMID:7520858] is_a: ARO:0000032 ! cephalosporin synonym: "CTB" EXACT [] synonym: "Cedax" EXACT [] xref: pubchem.compound:5282242 [Term] id: ARO:3000649 name: cefditoren namespace: antibiotic_resistance def: "Cefditoren is a semisynthetic cephalosporin active against staphylococci, streptococci, and and most enterobacteria. It is resistant to staphylococcal and most enterobacterial beta-lactamases, and is usually taken as the prodrug cefditoren pivoxil." [PMID:7813385] is_a: ARO:0000032 ! cephalosporin synonym: "CDN" EXACT [] xref: pubchem.compound:9571074 [Term] id: ARO:3000650 name: cefdinir namespace: antibiotic_resistance def: "Cefdinir is similar to cefixime with a modified side-chain at its 7-amino position. It also shares similar activity with cefixime but is more active against staphylococci. It has also be shown to enhance phagocytosis." [PMID:8026155] is_a: ARO:0000032 ! cephalosporin synonym: "CDR" EXACT [] xref: pubchem.compound:6915944 [Term] id: ARO:3000651 name: ceftaroline namespace: antibiotic_resistance def: "Ceftaroline is a novel cephalosporin active against methicillin resistant Staphylococcus aureus. Like other cephalosporins it binds penicillin-binding proteins to inhibit cell wall synthesis. It strongly binds with PBP2a, associated with methicillin resistance. It is taken orally as the prodrug ceftaroline fosamil." [PMID:21467022, PMID:18827379, PMID:27721280] is_a: ARO:0000032 ! cephalosporin synonym: "CPT" EXACT [] synonym: "T91825" EXACT [] synonym: "ceftaroline fosamil" EXACT [] xref: pubchem.compound:9852982 [Term] id: ARO:3000652 name: isepamicin namespace: antibiotic_resistance def: "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae." [PMID:8622111] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "isepamicine" EXACT [] synonym: "isepamicinum" EXACT [] xref: pubchem.compound:3037209 [Term] id: ARO:3000653 name: G418 namespace: antibiotic_resistance def: "A gentamicin class aminoglycoside antibiotic often used in mammalian cell culture work as a selectable marker for the neo cassette (APH3')." [PMID:4007271, PMID:6378088] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "geneticin" EXACT [] xref: pubchem.compound:123865 [Term] id: ARO:3000654 name: arbekacin namespace: antibiotic_resistance def: "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci." [PMID:7559197, PMID:10858356] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "habekacin" EXACT [] synonym: "haberacin" EXACT [] xref: pubchem.compound:68682 [Term] id: ARO:3000655 name: gentamicin B namespace: antibiotic_resistance def: "Gentamicin B is a semisynthetic aminoglycoside antibacterial." [PMID:9872733] is_a: ARO:3007382 ! gentamicin synonym: "betamicin" EXACT [] xref: pubchem.compound:11754987 [Term] id: ARO:3000656 name: AcrS namespace: antibiotic_resistance def: "AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux." [PMID:18567659] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004083 ! AcrEF-TolC confers resistance to ciprofloxacin relationship: regulates ARO:3000384 ! AcrAB-TolC relationship: regulates ARO:3000503 ! AcrEF-TolC synonym: "AcrS" EXACT CARD_Short_Name [] synonym: "ECK3251" EXACT [] synonym: "JW3232" EXACT [] synonym: "envR" EXACT [] synonym: "yhdK" EXACT [] [Term] id: ARO:3000657 name: paromomycin namespace: antibiotic_resistance def: "An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes." [PMID:11083628, PMID:8182014] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "Gabbomycin" EXACT [] synonym: "Humagel" EXACT [] synonym: "Humatin" EXACT [] synonym: "aminosidin" EXACT [] synonym: "aminosidine" EXACT [] synonym: "catenulin" EXACT [] synonym: "crestomycin" EXACT [] synonym: "estomycin" EXACT [] synonym: "hydroxymycin" EXACT [] synonym: "monomycin A" EXACT [] synonym: "neomycin E" EXACT [] synonym: "paucimycin" EXACT [] xref: pubchem.compound:165580 [Term] id: ARO:3000658 name: lividomycin namespace: antibiotic_resistance def: "Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose." [PMID:5091208, PMID:4586150] is_a: ARO:0000016 ! aminoglycoside antibiotic xref: pubchem.compound:72394 [Term] id: ARO:3000659 name: gatifloxacin namespace: antibiotic_resistance def: "Gatifloxacin is an 8-methoxy, 7-piperazinyl, 6-fluoroquinolone that can be taken orally or by intravenous administration. It is active against most Gram-positive and Gram-negative bacteria, but inactive against non-fermenting Gram-negative rods including Pseudomonas aeruginosa." [PMID:8522459] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "AM-1155" EXACT [] synonym: "Tequin" EXACT [] xref: pubchem.compound:5379 [Term] id: ARO:3000660 name: lomefloxacin namespace: antibiotic_resistance def: "Lomefloxacin is a difluoropiperazinyl quinolone, sharing similar activities with other fluoroquinolones. It is used to treat urinary tract infections. Relative to other fluoroquinolones, it has a longer half life and has higher serum concentrations." [PMID:8394795] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:3948 [Term] id: ARO:3000661 name: nalidixic acid namespace: antibiotic_resistance def: "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments." [PMID:18159374] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "nalidixin" EXACT [] xref: pubchem.compound:4421 [Term] id: ARO:3000662 name: norfloxacin namespace: antibiotic_resistance def: "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes." [PMID:3908074] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:4539 [Term] id: ARO:3000663 name: ofloxacin namespace: antibiotic_resistance def: "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant." [PMID:1611900, PMID:18159374, PMID:3028966] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Tarivid" EXACT [] synonym: "floxin" EXACT [] xref: pubchem.compound:4583 [Term] id: ARO:3000664 name: trovafloxacin namespace: antibiotic_resistance def: "Trovafloxacin is a trifluoroquinalone with a broad spectrum of activity that acts by inhibiting the uncoiling of supercoiled DNA. While potent against many Gram-positive and Gram-negative bacteria, it is less active against pseudomonads and Cl. difficile. It is usually taken as the prodrug trovafloxacin mesylate or alatrofloxacin mesylate for oral or intravenous administration, respectively." [] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Trovan" EXACT [] synonym: "alatrofloxacin" EXACT [] xref: pubchem.compound:62959 [Term] id: ARO:3000665 name: grepafloxacin namespace: antibiotic_resistance def: "Grepafloxacin is a broad-spectrum antibacterial quinoline. It is no longer taken due to its high toxicity." [PMID:15992094, PMID:18159374] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Raxar" EXACT [] xref: pubchem.compound:72474 [Term] id: ARO:3000666 name: sparfloxacin namespace: antibiotic_resistance def: "Sparfloxacin is a dimethylpiperazinyl difluoroquinolone that acts by inhibiting DNA gyrase. It is active against aerobic Gram-positive and Gram-negative bacteria, as well as some mycobacteria. It has moderate activity against some anaerobes." [PMID:1317145] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Zagam" EXACT [] xref: pubchem.compound:60464 [Term] id: ARO:3000667 name: demeclocycline namespace: antibiotic_resistance def: "Demeclocycline is a tetracycline analog with 7-chloro and 6-methyl groups. Due to its fast absorption and slow excretion, it maintains higher effective blood levels compared to other tetracyclines." [PMID:194065] is_a: ARO:3000050 ! tetracycline antibiotic synonym: "DMCTC" EXACT [] synonym: "declomycin" EXACT [] xref: pubchem.compound:54680690 [Term] id: ARO:3000668 name: oxytetracycline namespace: antibiotic_resistance def: "Oxytetracycline is a derivative of tetracycline with a 5-hydroxyl group. Its activity is similar to other tetracyclines." [PMID:11381101] is_a: ARO:3000050 ! tetracycline antibiotic xref: pubchem.compound:54675779 [Term] id: ARO:3000669 name: virginiamycin M1 namespace: antibiotic_resistance def: "Virginiamycin M1 is a streptogramin A antibiotic." [PMID:15700955] is_a: ARO:0000034 ! streptogramin A antibiotic synonym: "Pristinamycin IIA" EXACT [] synonym: "Pristinamycin IIB" EXACT [] synonym: "Virginiamycin IIB" EXACT [] xref: pubchem.compound:46936184 [Term] id: ARO:3000670 name: pleuromutilin antibiotic namespace: antibiotic_resistance def: "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes." [PMID:15554968, PMID:17360517, PMID:931799, PMID:20112168, PMID:11555289, PMID:16569865] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000671 name: tiamulin namespace: antibiotic_resistance def: "Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation." [PMID:11555289, PMID:20112168, PMID:19362093, PMID:15554968] is_a: ARO:3000670 ! pleuromutilin antibiotic xref: pubchem.compound:656958 [Term] id: ARO:3000672 name: madumycin II namespace: antibiotic_resistance def: "Madumycin II is a streptogramin A antibiotic." [PMID:15700955] is_a: ARO:0000034 ! streptogramin A antibiotic synonym: "A2315A" EXACT [] synonym: "madumicin II" EXACT [] xref: pubchem.compound:6441077 [Term] id: ARO:3000673 name: griseoviridin namespace: antibiotic_resistance def: "Griseoviridin is a streptogramin A antibiotic." [PMID:15700955] is_a: ARO:0000034 ! streptogramin A antibiotic xref: pubchem.compound:6441064 [Term] id: ARO:3000674 name: dalfopristin namespace: antibiotic_resistance def: "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria." [PMID:15700955] is_a: ARO:0000034 ! streptogramin A antibiotic xref: pubchem.compound:6323289 [Term] id: ARO:3000675 name: pristinamycin IB namespace: antibiotic_resistance def: "Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group)." [PMID:15700955] is_a: ARO:0000050 ! streptogramin B antibiotic synonym: "Virginiamycin S1" EXACT [] xref: pubchem.compound:443309 [Term] id: ARO:3000676 name: H-NS namespace: antibiotic_resistance def: "H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters." [PMID:14973023] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000373 ! EmrKY-TolC relationship: regulates ARO:3000503 ! AcrEF-TolC relationship: regulates ARO:3000788 ! MdtEF-TolC relationship: regulates ARO:3004083 ! AcrEF-TolC confers resistance to ciprofloxacin synonym: "H-NS" EXACT CARD_Short_Name [] synonym: "hns" EXACT [] [Term] id: ARO:3000677 name: virginiamycin S2 namespace: antibiotic_resistance def: "Virginiamycin S2 is a streptogramin B antibiotic." [PMID:15700955] is_a: ARO:0000050 ! streptogramin B antibiotic xref: pubchem.compound:101826968 [Term] id: ARO:3000678 name: pristinamycin IC namespace: antibiotic_resistance def: "Pristinamycin IC is a class B streptogramin derived from virginiamycin S1." [PMID:15700955] is_a: ARO:0000050 ! streptogramin B antibiotic synonym: "Vernamycin B gamma" EXACT [] synonym: "Virginiamycin S1" EXACT [] xref: pubchem.compound:443310 [Term] id: ARO:3000679 name: vernamycin C namespace: antibiotic_resistance def: "Vernamycin C is a streptogramin B antibiotic." [PMID:15700955] is_a: ARO:0000050 ! streptogramin B antibiotic xref: pubchem.compound:90478435 [Term] id: ARO:3000680 name: patricin A namespace: antibiotic_resistance def: "Patricin A is a streptogramin B antibiotic." [PMID:15700955] is_a: ARO:0000050 ! streptogramin B antibiotic xref: pubchem.compound:13041217 [Term] id: ARO:3000681 name: patricin B namespace: antibiotic_resistance def: "Patricin B is a streptogramin B antibiotic." [PMID:15700955] is_a: ARO:0000050 ! streptogramin B antibiotic xref: pubchem.compound:13041217 [Term] id: ARO:3000682 name: ostreogrycin B3 namespace: antibiotic_resistance def: "Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid." [PMID:15700955] is_a: ARO:0000050 ! streptogramin B antibiotic xref: pubchem.compound:71751769 [Term] id: ARO:3000683 name: sulfacetamide namespace: antibiotic_resistance def: "Sulfacetamide is a very soluable sulfonamide antibiotic previously used to treat urinary tract infections. Its relatively low activity and toxicity to those with Stevens-Johnson syndrome have reduced its use and availability." [PMID:8133250] is_a: ARO:3000282 ! sulfonamide antibiotic xref: pubchem.compound:5320 [Term] id: ARO:3000684 name: mafenide namespace: antibiotic_resistance def: "Mafenide is a sulfonamide used topically for treating burns." [PMID:4948236] is_a: ARO:3000282 ! sulfonamide antibiotic synonym: "ambamide" EXACT [] synonym: "maphenide" EXACT [] synonym: "sulfamylon" EXACT [] xref: pubchem.compound:3998 [Term] id: ARO:3000685 name: arylomycin namespace: antibiotic_resistance def: "Arylomycins are lipopeptide antibiotics, sharing a lipohexapeptide with a C-terminal tripeptide macrolide and varying by the length of its alkyl chains." [PMID:21545107] is_a: ARO:3000035 ! lipopeptide antibiotic xref: pubchem.compound:54586211 [Term] id: ARO:3000686 name: thiostrepton namespace: antibiotic_resistance def: "Thiostrepton is a cyclic peptide active against Gram-positive bacteria. It is produced by streptomyces bacteria." [PMID:5409975] is_a: ARO:3000053 ! peptide antibiotic synonym: "bryamycin" EXACT [] synonym: "thiactin" EXACT [] xref: pubchem.compound:16129666 [Term] id: ARO:3000687 name: moenomycin namespace: antibiotic_resistance def: "Moemomycin antibiotics are phosphoglycolipids that contain a 3-phosphoglyceric acid, often used as a mixture. They inhibit petidoglycan glycosyltransferases to prevent bacterial cell wall biosynthesis." [PMID:17117848, PMID:20730219] is_a: ARO:3000035 ! lipopeptide antibiotic synonym: "Flavomycin" EXACT [] synonym: "Flavophospholipol" EXACT [] synonym: "bambermycin" EXACT [] [Term] id: ARO:3000688 name: furazolidone namespace: antibiotic_resistance def: "Furazolidone is a nitrofuran antibiotic that is a non-ionic synthetic compound. It is taken orally and is active against many enteric pathogens. Furazolidone also has antiprotozoal activity and acts by inhibiting monoamine oxidase." [PMID:3514312] is_a: ARO:3004116 ! nitrofuran antibiotic synonym: "furazolidine" EXACT [] synonym: "furoxone" EXACT [] synonym: "nitrofurazolidone" EXACT [] xref: pubchem.compound:5323714 [Term] id: ARO:3000689 name: metronidazole namespace: antibiotic_resistance def: "Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death." [PMID:8444678] is_a: ARO:3004115 ! nitroimidazole antibiotic synonym: "Flagyl" EXACT [] synonym: "metronidazol" EXACT [] xref: pubchem.compound:4173 [Term] id: ARO:3000690 name: bleomycinic acid namespace: antibiotic_resistance def: "Bleomycinic acid is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids." [PMID:15700963] is_a: ARO:0000053 ! bleomycin is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:2410 [Term] id: ARO:3000691 name: bleomycin A2 namespace: antibiotic_resistance def: "Bleomycin A2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids." [PMID:15700963] is_a: ARO:0000053 ! bleomycin is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:5460769 [Term] id: ARO:3000692 name: bleomycin B2 namespace: antibiotic_resistance def: "Bleomycin B2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids." [PMID:15700963] is_a: ARO:0000053 ! bleomycin is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:5496540 [Term] id: ARO:3000693 name: defensin namespace: antibiotic_resistance def: "Defensins are natural cationic peptides that have antibiotic properties. It is part of the innate immune system of plants and animals." [PMID:12949495] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:56841867 [Term] id: ARO:3000694 name: magainin namespace: antibiotic_resistance def: "Magainins are antimicrobial peptides produced by amphibians skil cells as part of their innate immune system. It is active against a broad range of gram-negative and gram-positive bacteria, fungi and protozoa." [PMID:3277183] is_a: ARO:3000053 ! peptide antibiotic synonym: "megainin" EXACT [] [Term] id: ARO:3000695 name: actinomycin namespace: antibiotic_resistance def: "Actinomycins are peptide antibiotics that interact with DNA. This prevents RNA synthesis, thus preventing the production of proteins vital to the cell." [PMID:2410919] is_a: ARO:3000053 ! peptide antibiotic [Term] id: ARO:3000696 name: Dactinomycin namespace: antibiotic_resistance def: "Dactinomycin, also known as Actinomycin D, is a cyclic peptide antibiotic that interacts with DNA to inhibit RNA synthesis." [PMID:2410919] is_a: ARO:3000695 ! actinomycin synonym: "Actinomycin D" EXACT [] xref: pubchem.compound:457193 [Term] id: ARO:3000697 name: moenomycin A1 namespace: antibiotic_resistance def: "Moenomycin A1 is a major component of moenomycin mixtures. It is produced by Streptomyces ghanaensis, S. bambergiensis, S. ederensis, and S. geysiriensis." [PMID:17117848] is_a: ARO:3000035 ! lipopeptide antibiotic is_a: ARO:3000687 ! moenomycin xref: pubchem.compound:15235578 [Term] id: ARO:3000698 name: sulfasalazine namespace: antibiotic_resistance def: "Sulfasalazine is a derivative of the early sulfonamide sulfapyridine (salicylazosulfapyridine). It was developed to increase water solubility and is taken orally for ulcerative colitis." [PMID:22555] is_a: ARO:3000282 ! sulfonamide antibiotic synonym: "salicylazosulfapyridine" EXACT [] xref: pubchem.compound:5339 [Term] id: ARO:3000699 name: sulfamethizole namespace: antibiotic_resistance def: "Sulfamethizole is a short-acting sulfonamide that inhibits dihydropteroate synthetase." [PMID:2372557] is_a: ARO:3000282 ! sulfonamide antibiotic synonym: "Urolucosil" EXACT [] synonym: "sulfamethizol" EXACT [] synonym: "sulphamethizole" EXACT [] xref: pubchem.compound:5328 [Term] id: ARO:3000700 name: lividomycin A namespace: antibiotic_resistance def: "Lividomycin A is a pentasaccharide antibiotic which interferes with bacterial protein synthesis." [PMID:4586150, PMID:5092786] is_a: ARO:0000016 ! aminoglycoside antibiotic is_a: ARO:3000658 ! lividomycin xref: pubchem.compound:72394 [Term] id: ARO:3000701 name: lividomycin B namespace: antibiotic_resistance def: "Lividomycin B is a derivative of lividomycin A with a removed mannose group (demannosyllividomycin A). Livodomycins interfere with bacterial protein synthesis." [PMID:4586150, PMID:5034809] is_a: ARO:0000016 ! aminoglycoside antibiotic is_a: ARO:3000658 ! lividomycin xref: pubchem.compound:46174031 [Term] id: ARO:3000702 name: acrR namespace: antibiotic_resistance def: "AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance." [PMID:12121946] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000384 ! AcrAB-TolC [Term] id: ARO:3000704 name: cefalotin namespace: antibiotic_resistance def: "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases." [PMID:7571387, PMID:14251901] is_a: ARO:0000032 ! cephalosporin synonym: "CEF" EXACT [] synonym: "cephalothin" EXACT [] xref: pubchem.compound:6024 [Term] id: ARO:3000705 name: isopenicillin N namespace: antibiotic_resistance def: "Isopenicillin N is a natural penicillin derivative produced by Penicillium chrysogenum with activity similar to penicillin N." [PMID:4209314] is_a: ARO:3000008 ! penam xref: pubchem.compound:440723 [Term] id: ARO:3000706 name: penicillin N namespace: antibiotic_resistance def: "Penicillin N is a penicillin derivative produced by Cephalosporium acremonium." [PMID:4209314] is_a: ARO:3000008 ! penam xref: pubchem.compound:71724 [Term] id: ARO:3000707 name: antibiotic mixture namespace: antibiotic_resistance def: "Mixtures of antibiotics are commonly used clinically. These mixtures link to antibiotic molecules that are also listed in their respective families under antibiotic molecules. i.e. 'Gramicidin A' is part of the mixture 'gramicidin D', while 'Gramicidin A' is also a 'gramicidin', which is a 'peptide antibiotic'." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3000708 name: antibiotic target namespace: antibiotic_resistance def: "Antibiotic targets are components of the bacterial or fungal cell. Bacterial targets are usually significantly different from their eukaryotic counterparts to allow for selective antibacterial activity. Exceptions include antibiotics that are converted to an active form inside the bacterium. Resistance mechanisms may modify these targets to protect bacteria or fungi from the effects of antibiotics." [] is_a: ARO:1000001 ! process or component of antibiotic biology or chemistry [Term] id: ARO:3000709 name: cell wall synthesis enzyme targeted by antibiotic namespace: antibiotic_resistance def: "Cell wall biosynthesis provides bacteria with a layer of peptidoglycan that provides rigidity and protects the cell from lysis due to osmotic pressure. Cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, while mycobacteria have a unique cell wall composition." [PMID:1436736] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3000710 name: cell membrane component targeted by antibiotic namespace: antibiotic_resistance def: "Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive." [PMID:8528769, PMID:20818945, PMID:4334683, PMID:17572379] is_a: ARO:3000708 ! antibiotic target relationship: targeted_by ARO:0000022 ! polymyxin antibiotic relationship: targeted_by_antibiotic ARO:3000123 ! gramicidin relationship: targeted_by_antibiotic ARO:3000200 ! gramicidin S relationship: targeted_by_antibiotic ARO:3000222 ! gramicidin A relationship: targeted_by_antibiotic ARO:3000223 ! gramicidin B relationship: targeted_by_antibiotic ARO:3000224 ! gramicidin C relationship: targeted_by_antibiotic ARO:3000622 ! colistin A relationship: targeted_by_antibiotic ARO:3000624 ! colistin B relationship: targeted_by_antibiotic ARO:3000625 ! polymyxin B1 relationship: targeted_by_antibiotic ARO:3000626 ! polymyxin B2 relationship: targeted_by_antibiotic ARO:3000627 ! polymyxin B3 relationship: targeted_by_antibiotic ARO:3000628 ! polymyxin B4 relationship: targeted_by_antibiotic ARO:3000693 ! defensin relationship: targeted_by_antibiotic ARO:3000694 ! magainin [Term] id: ARO:3000711 name: protein synthesis machinery targeted by antibiotic namespace: antibiotic_resistance def: "Protein synthesis in bacteria is accomplished by cytosolic ribosomes that are structurally different from eukaryotic ribosomes, and thus a target for many antibiotics. By inhibiting ribosomal activity, either by directly binding to the ribosome or interacting with co-factors, antibiotics prevent protein synthesis." [] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3000712 name: nucleic acid synthesis machinery targeted by antibiotic namespace: antibiotic_resistance def: "Bacterial DNA and RNA synthesis includes many enzymes unique to bacteria that are targeted by antibiotics." [PMID:22458504] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3000713 name: nucleic acid targeted by antibiotic namespace: antibiotic_resistance def: "Nucleic acids can also be targeted by antibiotics. These drugs are usually converted to an active form by enzymes unique to bacteria to prevent toxicity to the host." [PMID:15685195] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3000714 name: folate synthesis enzyme targeted by antibiotic namespace: antibiotic_resistance def: "Enzymes in the folate synthesis pathway are targeted by two main classes of antibiotics: sulfonamides and diaminopyrimidines. Inhibition of these enzymes block the production of key precursors for nucleotides and amino acids." [PMID:4387360] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3000715 name: isoprenoid synthesis enzyme targeted by antibiotic namespace: antibiotic_resistance def: "Enzymes in this pathway generate important precursors for macromolecules. While eukaryotes and prokaryotes both synthesize isoprenoids, many bacteria and notably mycobacteria use an alternative pathway that is targeted by antibiotics." [PMID:17430177, PMID:16321944] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3000716 name: mycolic acid synthesis enzyme targeted by antibiotic namespace: antibiotic_resistance def: "Mycolic acids are produced by mycobacteria. These fatty acids are required for the construction of cell walls. Enzymes that are targeted by antibiotics include synthases, elongases, and dehydrogenases." [PMID:1656850, PMID:8143118] is_a: ARO:3000708 ! antibiotic target relationship: targeted_by_antibiotic ARO:3000520 ! isoniazid [Term] id: ARO:3000717 name: antibiotic sensitive signal peptidase I namespace: antibiotic_resistance def: "Signal peptidase I is a bacterial signal peptidase that cleaves signal peptides from translated proteins. These signal peptides direct proteins to their destination, and then must be cleaved in order to function." [PMID:7023361, PMID:21189343, PMID:15173160] is_a: ARO:3000708 ! antibiotic target relationship: targeted_by_antibiotic ARO:3000685 ! arylomycin [Term] id: ARO:3000718 name: marR namespace: antibiotic_resistance def: "MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB." [PMID:12027588, PMID:9333027] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000384 ! AcrAB-TolC [Term] id: ARO:3000719 name: bacitracin sensitive isoprenyl pyrophosphate namespace: antibiotic_resistance def: "Isoprepnyl pyrophosphate removes a phosphate group that is added from the peptidoglycan subunit to permit its transfer across the cell membrane. The phosphate group must be removed before its incorporation into peptidoglycan macromolecules." [PMID:4332017, PMID:18258256, PMID:6752975, PMID:4350651] is_a: ARO:3000709 ! cell wall synthesis enzyme targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000041 ! bacitracin relationship: targeted_by_antibiotic ARO:3000629 ! bacitracin A relationship: targeted_by_antibiotic ARO:3000630 ! bacitracin B relationship: targeted_by_antibiotic ARO:3000631 ! bacitracin F [Term] id: ARO:3000720 name: acyl-D-alanyl-D-alanine namespace: antibiotic_resistance def: "The acyl-D-alanyl-D-alanine group is found at the terminal end of the pentapeptide chains of peptidoglycan subunits. Antibiotics that bind to this group block the addition of subunits, inhibiting peptidoglycan synthesis. This group is most accessible in Gram-postive bacteria." [PMID:18258256] is_a: ARO:3000721 ! cell wall component targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000028 ! vancomycin relationship: targeted_by_antibiotic ARO:0000029 ! teicoplanin relationship: targeted_by_antibiotic ARO:3000022 ! ristocetin relationship: targeted_by_antibiotic ARO:3000117 ! antibiotic A47934 relationship: targeted_by_antibiotic ARO:3000120 ! balhimycin relationship: targeted_by_antibiotic ARO:3000184 ! chloroeremomycin relationship: targeted_by_antibiotic ARO:3000189 ! oritavancin relationship: targeted_by_antibiotic ARO:3000466 ! dalbavancin relationship: targeted_by_antibiotic ARO:3000488 ! telavancin relationship: targeted_by_antibiotic ARO:3000525 ! antibiotic A40926 relationship: targeted_by_antibiotic ARO:3000767 ! avoparcin [Term] id: ARO:3000721 name: cell wall component targeted by antibiotic namespace: antibiotic_resistance def: "The cell wall is unique to bacteria and provides rigidity and protects the cell from lysis due to osmotic pressure. Its characteristic component is peptidoglycan, though cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, as well as mycobacteria." [PMID:4568761] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3000722 name: cycloserine sensitive alr namespace: antibiotic_resistance def: "Alanine racemase (alr) converts the natural L-alanine to the D-alanine required in the pentapeptide chains in peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria." [PMID:19748470, PMID:4555420] is_a: ARO:3000709 ! cell wall synthesis enzyme targeted by antibiotic relationship: targeted_by_antibiotic ARO:3000760 ! cycloserine [Term] id: ARO:3000723 name: cycloserine sensitive D-alanine synthetase namespace: antibiotic_resistance def: "D-Alanine synthetase (or ligase), also known as ddla, joins two D-alanines before their addition to the pentapeptide chains of peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria." [PMID:14479178] is_a: ARO:3000709 ! cell wall synthesis enzyme targeted by antibiotic relationship: targeted_by_antibiotic ARO:3000760 ! cycloserine [Term] id: ARO:3000724 name: fosfomycin sensitive pyruvyl transferase (murA) namespace: antibiotic_resistance def: "Pyruvyl transferase is responsible for the conversion of N-acetylglucosamine (NAG) to N-acetylmuramic acid (NAMA). NAMA is a part of the macromolecular backbone of peptidoglycans. Pyruvyl transferase is found in both Gram-positive and Gram-negative bacteria." [PMID:4605290] is_a: ARO:3000709 ! cell wall synthesis enzyme targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000025 ! fosfomycin [Term] id: ARO:3000725 name: antibiotic sensitive aftA namespace: antibiotic_resistance def: "Arabinofuranosyltransferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls." [PMID:18174142, PMID:19596878] is_a: ARO:3000709 ! cell wall synthesis enzyme targeted by antibiotic relationship: targeted_by_antibiotic ARO:3000497 ! ethambutol [Term] id: ARO:3000726 name: pentaglycyl bridge namespace: antibiotic_resistance def: "The pentaglycyl bridge is part of Gram-positive peptidoglycan, allowing the formation of a thick and rigid cell wall." [PMID:18258256] is_a: ARO:3000721 ! cell wall component targeted by antibiotic relationship: targeted_by_antibiotic ARO:3000189 ! oritavancin [Term] id: ARO:3000727 name: 50S ribosomal subunit namespace: antibiotic_resistance def: "The larger of two ribosomal subunits that make up the 70S bacterial ribosome." [PMID:10445875, PMID:16257828] is_a: ARO:3000711 ! protein synthesis machinery targeted by antibiotic relationship: targeted_by ARO:0000000 ! macrolide antibiotic [Term] id: ARO:3000728 name: 30S ribosomal subunit namespace: antibiotic_resistance def: "The smaller of two ribosomal subunits that make up the 70S bacterial ribosome." [PMID:15755955] is_a: ARO:3000711 ! protein synthesis machinery targeted by antibiotic relationship: targeted_by ARO:0000042 ! glycylcycline [Term] id: ARO:3000729 name: ribosomal complex namespace: antibiotic_resistance def: "The ribosomal complex can be targeted by antibiotics that stabilize the entire complex and prevent further translation. These antibiotics target both subunits in the process of protein translation." [PMID:202460, PMID:17515906] is_a: ARO:3000711 ! protein synthesis machinery targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000018 ! viomycin relationship: targeted_by_antibiotic ARO:3000490 ! tuberactinomycin [Term] id: ARO:3000730 name: elongation factor G namespace: antibiotic_resistance def: "Elongation factor G (EF-G) provides energy for the translocation step in protein synthesis. Antibiotics that target EF-G allow one round of translocation but prevent EF-G from dissociating from the ribosome-RNA complex." [PMID:17980694, PMID:9678602] is_a: ARO:3000711 ! protein synthesis machinery targeted by antibiotic relationship: targeted_by_antibiotic ARO:3000759 ! fusidic acid [Term] id: ARO:3000731 name: elongation factor Tu namespace: antibiotic_resistance def: "Elongation factor Tu is required for peptide elongation in bacterial protein synthesis." [PMID:9678602, PMID:364475] is_a: ARO:3000711 ! protein synthesis machinery targeted by antibiotic relationship: targeted_by ARO:3001219 ! elfamycin antibiotic relationship: targeted_by_antibiotic ARO:3000586 ! pulvomycin relationship: targeted_by_antibiotic ARO:3001237 ! GE2270A relationship: targeted_by_antibiotic ARO:3001242 ! enacyloxin IIa relationship: targeted_by_antibiotic ARO:3001310 ! kirromycin-like antibiotics relationship: targeted_by_antibiotic ARO:3003414 ! LFF571 synonym: "EF-Tu" EXACT [] [Term] id: ARO:3000732 name: antibiotic sensitive Isoleucyl-tRNA transferase namespace: antibiotic_resistance def: "Isoleucyl-tRNA transferase recognizes isoleucine codons and works with the ribosome to incorporate isoleucine amino acids into polypeptide chains. It can be targeted by antibiotics that have an analog of isoleucine through competitive inhibition." [PMID:5803296, PMID:7929087] is_a: ARO:3000711 ! protein synthesis machinery targeted by antibiotic relationship: targeted_by_antibiotic ARO:3000554 ! mupirocin synonym: "ileS" EXACT [] [Term] id: ARO:3000733 name: fluoroquinolone sensitive gyrA namespace: antibiotic_resistance def: "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling." [PMID:9293187, PMID:1657531] is_a: ARO:3003254 ! antibiotic sensitive DNA topoisomerase subunit gyrA relationship: targeted_by ARO:0000001 ! fluoroquinolone antibiotic relationship: targeted_by_antibiotic ARO:0000023 ! enoxacin relationship: targeted_by_antibiotic ARO:0000036 ! ciprofloxacin relationship: targeted_by_antibiotic ARO:0000071 ! levofloxacin relationship: targeted_by_antibiotic ARO:0000074 ! moxifloxacin relationship: targeted_by_antibiotic ARO:3000659 ! gatifloxacin relationship: targeted_by_antibiotic ARO:3000660 ! lomefloxacin relationship: targeted_by_antibiotic ARO:3000661 ! nalidixic acid relationship: targeted_by_antibiotic ARO:3000662 ! norfloxacin relationship: targeted_by_antibiotic ARO:3000663 ! ofloxacin relationship: targeted_by_antibiotic ARO:3000664 ! trovafloxacin relationship: targeted_by_antibiotic ARO:3000665 ! grepafloxacin relationship: targeted_by_antibiotic ARO:3000666 ! sparfloxacin relationship: targeted_by_antibiotic ARO:3000762 ! pefloxacin relationship: targeted_by_antibiotic ARO:3004010 ! cinoxacin relationship: targeted_by_antibiotic ARO:3004011 ! clinafloxacin relationship: targeted_by_antibiotic ARO:3004012 ! clofazimine relationship: targeted_by_antibiotic ARO:3004013 ! fleroxacin synonym: "gyrase A" EXACT [] [Term] id: ARO:3000734 name: antibiotic sensitive DNA topoisomerase subunit gyrB namespace: antibiotic_resistance def: "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the beta-subunit is sufficient to inhibit DNA supercoiling." [PMID:1657531, PMID:9293187] is_a: ARO:3000766 ! antibiotic sensitive topoisomerase subunit relationship: targeted_by ARO:3000103 ! aminocoumarin antibiotic relationship: targeted_by_antibiotic ARO:3000111 ! novobiocin relationship: targeted_by_antibiotic ARO:3000132 ! clorobiocin relationship: targeted_by_antibiotic ARO:3000150 ! coumermycin A1 synonym: "gyrase B" EXACT [] synonym: "gyrase beta subunit" EXACT [] synonym: "gyrase subunit B" EXACT [] [Term] id: ARO:3000735 name: Fluoroquinolone sensitive parC namespace: antibiotic_resistance def: "parC is a subunit of the DNA topoisomerase IV and is sensitive to fluoroquinolone." [PMID:9293187] is_a: ARO:3003256 ! antibiotic sensitive DNA topoisomerase subunit parC relationship: targeted_by ARO:0000001 ! fluoroquinolone antibiotic relationship: targeted_by_antibiotic ARO:0000036 ! ciprofloxacin relationship: targeted_by_antibiotic ARO:0000071 ! levofloxacin relationship: targeted_by_antibiotic ARO:3000662 ! norfloxacin relationship: targeted_by_antibiotic ARO:3000663 ! ofloxacin relationship: targeted_by_antibiotic ARO:3000762 ! pefloxacin [Term] id: ARO:3000736 name: rho transcription terminator factor namespace: antibiotic_resistance def: "The rho transcription terminator factor moves along RNA as it is transcribed, unwinding the RNA from the DNA. It is also responsible for recognizing transcription termination pause sites, slowing down RNA polymerase and allowing mRNA to be released." [PMID:8466900, PMID:21326894] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000055 ! bicyclomycin [Term] id: ARO:3000737 name: rifamycin sensitive beta-subunit of RNA polymerase (rpoB) namespace: antibiotic_resistance def: "The beta-subunit of RNA polymerase is targeted as a complex. When blocked, RNA strand elongation cannot continue after the first few nucleotides." [PMID:15700959] is_a: ARO:3003277 ! antibiotic sensitive beta-subunit of RNA polymerase (rpoB) relationship: targeted_by ARO:3000157 ! rifamycin antibiotic relationship: targeted_by_antibiotic ARO:3000169 ! rifampin relationship: targeted_by_antibiotic ARO:3000517 ! rifaximin relationship: targeted_by_antibiotic ARO:3000530 ! rifabutin relationship: targeted_by_antibiotic ARO:3000534 ! rifapentine [Term] id: ARO:3000738 name: deoxyribonucleic acid namespace: antibiotic_resistance def: "Antibiotics can target DNA to cause strand breaks or prevent transcription. The activity of these antibiotics can be context dependent: some antibiotics are converted to an active form only in certain species, while others target DNA as it is being transcribed." [PMID:15685195, PMID:4941089, PMID:63969] is_a: ARO:3000713 ! nucleic acid targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000053 ! bleomycin relationship: targeted_by_antibiotic ARO:0000075 ! nitrofurantoin relationship: targeted_by_antibiotic ARO:3000690 ! bleomycinic acid relationship: targeted_by_antibiotic ARO:3000691 ! bleomycin A2 relationship: targeted_by_antibiotic ARO:3000692 ! bleomycin B2 synonym: "DNA" EXACT [] [Term] id: ARO:3000739 name: RNA guanosine binding site namespace: antibiotic_resistance def: "RNA intron self-splicing action can be inhibited by antibiotics that target a G-binding site to compete with the guanosine cofactor." [PMID:7509881] is_a: ARO:3000740 ! ribonucleic acid relationship: targeted_by_antibiotic ARO:0000018 ! viomycin relationship: targeted_by_antibiotic ARO:3000490 ! tuberactinomycin [Term] id: ARO:3000740 name: ribonucleic acid namespace: antibiotic_resistance def: "Many types of ribonucleic acids (RNAs) are targeted by antibiotics, including mRNA templates and ribosomal RNA. Some antibiotics target all RNAs and cause strand breaks." [PMID:15685195, PMID:7509881, PMID:63969, PMID:1701259] is_a: ARO:3000713 ! nucleic acid targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000053 ! bleomycin relationship: targeted_by_antibiotic ARO:3000690 ! bleomycinic acid relationship: targeted_by_antibiotic ARO:3000691 ! bleomycin A2 relationship: targeted_by_antibiotic ARO:3000692 ! bleomycin B2 synonym: "RNA" EXACT [] [Term] id: ARO:3000741 name: transcription complex DNA namespace: antibiotic_resistance def: "DNA in the transcriptional complex is partially unwound, allowing antibiotics to target exposed bases and prevent DNA transcription." [PMID:13948669, PMID:2410919] is_a: ARO:3000738 ! deoxyribonucleic acid relationship: targeted_by ARO:3000695 ! actinomycin relationship: targeted_by_antibiotic ARO:3000696 ! Dactinomycin [Term] id: ARO:3000742 name: anaerobe DNA namespace: antibiotic_resistance def: "DNA in anaerobes are targeted by antibiotics that are converted to an active form in the anaerobe environment. For nitroimidazoles, the antibiotic is reduced to a highly oxidative intermediate that causes DNA oxidation and double-stranded breaks." [PMID:8444678] is_a: ARO:3000738 ! deoxyribonucleic acid relationship: targeted_by_antibiotic ARO:3000689 ! metronidazole [Term] id: ARO:3000743 name: 1-deoxy-D-xylulose 5-phosphate reductoisomerase namespace: antibiotic_resistance def: "This reductoisomerase is found in an alternate isoprenoid synthase pathway that is mevalonate independent. Isoprenoids are important precursors to many other macromolecules. This non-mevalonate pathway is used by plants and most bacteria, including mycobacteria, but not eukaryotes, allowing for selectivea action. Staphylococcus aureus and some other Gram-positive bacteria use a mevalonate-dependent pathway, and are resistant against 1-deoxy-D-xylose 5-phosphate reductoisomerase inhibitors." [PMID:16321944, PMID:17430177] is_a: ARO:3000715 ! isoprenoid synthesis enzyme targeted by antibiotic relationship: targeted_by_antibiotic ARO:3000758 ! fosmidomycin [Term] id: ARO:3000744 name: antibiotic sensitive dihydropteroate synthase namespace: antibiotic_resistance def: "Dihydropteroate synthase catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, and a precursor of many nucleotides and amino acids. Inhibiting dihydropteroate leads to slow cell death, as bacteria can survive on existing folate storages for a few generations." [PMID:12111724] is_a: ARO:3000714 ! folate synthesis enzyme targeted by antibiotic relationship: targeted_by ARO:3000282 ! sulfonamide antibiotic relationship: targeted_by ARO:3003401 ! sulfone antibiotic relationship: targeted_by_antibiotic ARO:3000324 ! sulfadiazine relationship: targeted_by_antibiotic ARO:3000325 ! sulfadimidine relationship: targeted_by_antibiotic ARO:3000327 ! sulfadoxine relationship: targeted_by_antibiotic ARO:3000329 ! sulfamethoxazole relationship: targeted_by_antibiotic ARO:3000330 ! sulfisoxazole relationship: targeted_by_antibiotic ARO:3000683 ! sulfacetamide relationship: targeted_by_antibiotic ARO:3000684 ! mafenide relationship: targeted_by_antibiotic ARO:3000698 ! sulfasalazine relationship: targeted_by_antibiotic ARO:3000699 ! sulfamethizole relationship: targeted_by_antibiotic ARO:3003412 ! dapsone [Term] id: ARO:3000745 name: antibiotic sensitive dihydrofolate reductase namespace: antibiotic_resistance def: "Dihydrofolate reductase synthesizes the co-enzyme tetrahydrofolic acid, which is also an essential precursor in the de novo synthesis of the DNA nucleotide thymidine." [PMID:12781525] is_a: ARO:3000714 ! folate synthesis enzyme targeted by antibiotic relationship: targeted_by ARO:3000171 ! diaminopyrimidine antibiotic relationship: targeted_by_antibiotic ARO:3000188 ! trimethoprim relationship: targeted_by_antibiotic ARO:3000269 ! brodimoprim relationship: targeted_by_antibiotic ARO:3000284 ! tetroxoprim relationship: targeted_by_antibiotic ARO:3000337 ! iclaprim synonym: "FolA" EXACT [] [Term] id: ARO:3000746 name: mepR namespace: antibiotic_resistance def: "MepR is an upstream repressor of MepA in Staphylococcus aureus. It is part of the mepRAB operon." [PMID:15855507, PMID:15855508, PMID:16569840] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000026 ! mepA synonym: "mepR" EXACT CARD_Short_Name [] [Term] id: ARO:3000747 name: mef namespace: antibiotic_resistance def: "Mef efflux pumps are MFS-type transporters that confer macrolide resistance in Streptococcus pneumoniae." [PMID:16189099] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic [Term] id: ARO:3000748 name: subunit of efflux pump conferring antibiotic resistance namespace: antibiotic_resistance def: "Subunits of efflux proteins that pump antibiotic out of a cell to confer resistance." [] is_a: ARO:3000159 ! efflux pump complex or subunit conferring antibiotic resistance [Term] id: ARO:3000749 name: beta-lactam sensitive penicillin-binding protein namespace: antibiotic_resistance def: "Penicillin-binding proteins (PBPs) are responsible for transpeptidation, joining subunits to form peptidoglycan. They are numbered according to descending molecular weight, and may vary between species. These numbers represent the PBPs of E. coli. Inhibition of the larger PBPs responsible for transpeptidation (1-3) are lethal. Smaller PBPs (4-6) are involed in carboxypeptidation; inhibition of these is non-lethal." [PMID:3055170] is_a: ARO:3000709 ! cell wall synthesis enzyme targeted by antibiotic relationship: targeted_by ARO:0000044 ! cephamycin relationship: targeted_by ARO:3000007 ! beta-lactam antibiotic relationship: targeted_by_antibiotic ARO:0000008 ! cefoxitin relationship: targeted_by_antibiotic ARO:0000011 ! cloxacillin relationship: targeted_by_antibiotic ARO:0000015 ! methicillin relationship: targeted_by_antibiotic ARO:0000043 ! carbenicillin relationship: targeted_by_antibiotic ARO:0000054 ! penicillin relationship: targeted_by_antibiotic ARO:0000056 ! oxacillin relationship: targeted_by_antibiotic ARO:0000058 ! cefazolin relationship: targeted_by_antibiotic ARO:0000059 ! cefepime relationship: targeted_by_antibiotic ARO:0000060 ! ceftazidime relationship: targeted_by_antibiotic ARO:0000061 ! ceftobiprole relationship: targeted_by_antibiotic ARO:0000062 ! ceftriaxone relationship: targeted_by_antibiotic ARO:0000063 ! cefuroxime relationship: targeted_by_antibiotic ARO:0000064 ! amoxicillin relationship: targeted_by_antibiotic ARO:0000070 ! ertapenem relationship: targeted_by_antibiotic ARO:0000073 ! meropenem relationship: targeted_by_antibiotic ARO:0000078 ! piperacillin relationship: targeted_by_antibiotic ARO:3000170 ! imipenem relationship: targeted_by_antibiotic ARO:3000550 ! aztreonam relationship: targeted_by_antibiotic ARO:3000632 ! benzylpenicillin relationship: targeted_by_antibiotic ARO:3000633 ! phenoxymethylpenicillin relationship: targeted_by_antibiotic ARO:3000634 ! propicillin relationship: targeted_by_antibiotic ARO:3000635 ! dicloxacillin relationship: targeted_by_antibiotic ARO:3000636 ! flucloxacillin relationship: targeted_by_antibiotic ARO:3000637 ! ampicillin relationship: targeted_by_antibiotic ARO:3000638 ! azlocillin relationship: targeted_by_antibiotic ARO:3000639 ! mezlocillin relationship: targeted_by_antibiotic ARO:3000640 ! doripenem relationship: targeted_by_antibiotic ARO:3000641 ! cefalexin relationship: targeted_by_antibiotic ARO:3000642 ! cefadroxil relationship: targeted_by_antibiotic ARO:3000643 ! cefotiam relationship: targeted_by_antibiotic ARO:3000644 ! cefaclor relationship: targeted_by_antibiotic ARO:3000645 ! cefotaxime relationship: targeted_by_antibiotic ARO:3000646 ! cefixime relationship: targeted_by_antibiotic ARO:3000647 ! cefpodoxime relationship: targeted_by_antibiotic ARO:3000648 ! ceftibuten relationship: targeted_by_antibiotic ARO:3000649 ! cefditoren relationship: targeted_by_antibiotic ARO:3000650 ! cefdinir relationship: targeted_by_antibiotic ARO:3000651 ! ceftaroline relationship: targeted_by_antibiotic ARO:3000704 ! cefalotin relationship: targeted_by_antibiotic ARO:3000705 ! isopenicillin N relationship: targeted_by_antibiotic ARO:3000706 ! penicillin N relationship: targeted_by_antibiotic ARO:3000761 ! mecillinam relationship: targeted_by_antibiotic ARO:3004001 ! cefmetazole relationship: targeted_by_antibiotic ARO:3004002 ! cefonicid relationship: targeted_by_antibiotic ARO:3004005 ! cefprozil relationship: targeted_by_antibiotic ARO:3004006 ! ceftiofur relationship: targeted_by_antibiotic ARO:3004007 ! ceftizoxime relationship: targeted_by_antibiotic ARO:3004008 ! cephapirin relationship: targeted_by_antibiotic ARO:3004009 ! cefradine relationship: targeted_by_antibiotic ARO:3004016 ! loracarbef relationship: targeted_by_antibiotic ARO:3004017 ! moxalactam [Term] id: ARO:3000750 name: protein of two-component regulatory system modulating antibiotic efflux namespace: antibiotic_resistance def: "A protein, either a histidine kinase or a response regulator, that is part of a two-component regulatory system that directly or indirectly change rates of antibiotic efflux." [] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux [Term] id: ARO:3000753 name: abeM namespace: antibiotic_resistance def: "AbeM is an multidrug efflux pump found in Acinetobacter baumannii." [PMID:16189122] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "abeM" EXACT CARD_Short_Name [] [Term] id: ARO:3000754 name: antibiotic sensitive peptidyl transferase (23S rRNA) namespace: antibiotic_resistance def: "The bacterial 23S rRNA, at the P site of the 50S subunit, has peptidyl transferase activity and is responsible for peptide synthesis and elongation." [PMID:16257828, PMID:16569865, PMID:10445875] is_a: ARO:3000740 ! ribonucleic acid relationship: part_of ARO:3000727 ! 50S ribosomal subunit relationship: targeted_by ARO:0000017 ! lincosamide antibiotic relationship: targeted_by ARO:0000026 ! streptogramin antibiotic relationship: targeted_by ARO:0000034 ! streptogramin A antibiotic relationship: targeted_by ARO:3000387 ! phenicol antibiotic relationship: targeted_by ARO:3000670 ! pleuromutilin antibiotic relationship: targeted_by_antibiotic ARO:0000046 ! lincomycin relationship: targeted_by_antibiotic ARO:0000066 ! clindamycin relationship: targeted_by_antibiotic ARO:3000382 ! azidamfenicol relationship: targeted_by_antibiotic ARO:3000385 ! chloramphenicol relationship: targeted_by_antibiotic ARO:3000456 ! thiamphenicol relationship: targeted_by_antibiotic ARO:3000461 ! florfenicol relationship: targeted_by_antibiotic ARO:3000583 ! pristinamycin IA relationship: targeted_by_antibiotic ARO:3000584 ! quinupristin relationship: targeted_by_antibiotic ARO:3000669 ! virginiamycin M1 relationship: targeted_by_antibiotic ARO:3000672 ! madumycin II relationship: targeted_by_antibiotic ARO:3000673 ! griseoviridin relationship: targeted_by_antibiotic ARO:3000674 ! dalfopristin relationship: targeted_by_antibiotic ARO:3000675 ! pristinamycin IB relationship: targeted_by_antibiotic ARO:3000677 ! virginiamycin S2 relationship: targeted_by_antibiotic ARO:3000678 ! pristinamycin IC relationship: targeted_by_antibiotic ARO:3000679 ! vernamycin C relationship: targeted_by_antibiotic ARO:3000680 ! patricin A relationship: targeted_by_antibiotic ARO:3000681 ! patricin B relationship: targeted_by_antibiotic ARO:3000682 ! ostreogrycin B3 [Term] id: ARO:3000755 name: antibiotic sensitive 16S rRNA namespace: antibiotic_resistance def: "The 16S rRNA of the 30S ribosomal subunit helps to stabilize the aminoacyl-tRNAs for pairing with the mRNA codons. Some antibiotics (aminoglycosides) that target the 16S rRNA lead to mRNA misreading as well as premature termination. Other antibiotics (tetracyclines) that target the 16S rRNA prevent incoming charged-tRNAs from binding to the ribosome's A-site, stopping elongation." [PMID:9662506] is_a: ARO:3000740 ! ribonucleic acid relationship: part_of ARO:3000728 ! 30S ribosomal subunit relationship: targeted_by ARO:0000016 ! aminoglycoside antibiotic relationship: targeted_by ARO:3000050 ! tetracycline antibiotic relationship: targeted_by_antibiotic ARO:0000003 ! astromicin relationship: targeted_by_antibiotic ARO:0000005 ! neomycin relationship: targeted_by_antibiotic ARO:0000007 ! dibekacin relationship: targeted_by_antibiotic ARO:0000012 ! streptothricin relationship: targeted_by_antibiotic ARO:0000013 ! amikacin relationship: targeted_by_antibiotic ARO:0000014 ! gentamicin C relationship: targeted_by_antibiotic ARO:0000021 ! ribostamycin relationship: targeted_by_antibiotic ARO:0000024 ! butirosin relationship: targeted_by_antibiotic ARO:0000030 ! tigecycline relationship: targeted_by_antibiotic ARO:0000035 ! sisomicin relationship: targeted_by_antibiotic ARO:0000037 ! apramycin relationship: targeted_by_antibiotic ARO:0000038 ! netilmicin relationship: targeted_by_antibiotic ARO:0000039 ! spectinomycin relationship: targeted_by_antibiotic ARO:0000040 ! streptomycin relationship: targeted_by_antibiotic ARO:0000049 ! kanamycin A relationship: targeted_by_antibiotic ARO:0000051 ! tetracycline relationship: targeted_by_antibiotic ARO:0000052 ! tobramycin relationship: targeted_by_antibiotic ARO:0000069 ! doxycycline relationship: targeted_by_antibiotic ARO:3000119 ! edeine relationship: targeted_by_antibiotic ARO:3000152 ! minocycline relationship: targeted_by_antibiotic ARO:3000214 ! hygromycin B relationship: targeted_by_antibiotic ARO:3000528 ! chlortetracycline relationship: targeted_by_antibiotic ARO:3000652 ! isepamicin relationship: targeted_by_antibiotic ARO:3000653 ! G418 relationship: targeted_by_antibiotic ARO:3000654 ! arbekacin relationship: targeted_by_antibiotic ARO:3000655 ! gentamicin B relationship: targeted_by_antibiotic ARO:3000657 ! paromomycin relationship: targeted_by_antibiotic ARO:3000658 ! lividomycin relationship: targeted_by_antibiotic ARO:3000667 ! demeclocycline relationship: targeted_by_antibiotic ARO:3000668 ! oxytetracycline relationship: targeted_by_antibiotic ARO:3000700 ! lividomycin A relationship: targeted_by_antibiotic ARO:3000701 ! lividomycin B [Term] id: ARO:3000756 name: 30S ribosomal subunit P-site namespace: antibiotic_resistance def: "The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain. Antibiotics that target the P-site block fMet-tRNA from entering, thus inhibiting peptide elongation." [PMID:15755955] is_a: ARO:3000728 ! 30S ribosomal subunit relationship: targeted_by ARO:3000119 ! edeine relationship: targeted_by_antibiotic ARO:0000047 ! puromycin relationship: targeted_by_antibiotic ARO:3000130 ! edeine A relationship: targeted_by_antibiotic ARO:3000134 ! edeine B relationship: targeted_by_antibiotic ARO:3000135 ! edeine D relationship: targeted_by_antibiotic ARO:3000136 ! edeine F [Term] id: ARO:3000757 name: 50S ribosomal subunit P-site namespace: antibiotic_resistance def: "The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain, and is a common target for many antibiotics that inhibit the 50S ribosomal subunit. Some antibiotics (oxazolidinones) block the 50S subunit from interacting with the 30S subunit to prevent the formation of the ribosomal complex. Other antibiotics (thiostrepton) block the 50S subunit from interacting with elongation factors G and Tu (EF-G, Ef-Tu), preventing GTP-dependent reactions of peptidyl transferase, and translocation, respectively. Other antibiotics (macrolides) prevent protein translocation." [PMID:15755955, PMID:15700955, PMID:795651] is_a: ARO:3000727 ! 50S ribosomal subunit relationship: targeted_by ARO:0000050 ! streptogramin B antibiotic relationship: targeted_by ARO:3000079 ! oxazolidinone antibiotic relationship: targeted_by_antibiotic ARO:0000006 ! erythromycin relationship: targeted_by_antibiotic ARO:0000027 ! roxithromycin relationship: targeted_by_antibiotic ARO:0000057 ! telithromycin relationship: targeted_by_antibiotic ARO:0000065 ! clarithromycin relationship: targeted_by_antibiotic ARO:0000072 ! linezolid relationship: targeted_by_antibiotic ARO:3000145 ! tylosin relationship: targeted_by_antibiotic ARO:3000156 ! spiramycin relationship: targeted_by_antibiotic ARO:3000158 ! azithromycin relationship: targeted_by_antibiotic ARO:3000176 ! dirithromycin relationship: targeted_by_antibiotic ARO:3000686 ! thiostrepton [Term] id: ARO:3000758 name: fosmidomycin namespace: antibiotic_resistance def: "Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme in the non-mevalonate pathway for isoprenoid synthesis. It is active against enterobacteria, but not against Gram-positive bacteria or anaerobes." [PMID:10477522] is_a: ARO:3007149 ! phosphonic acid antibiotic xref: pubchem.compound:572 [Term] id: ARO:3000759 name: fusidic acid namespace: antibiotic_resistance def: "Fusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to block protein synthesis." [PMID:17980694, PMID:7730233] is_a: ARO:3007153 ! fusidane antibiotic synonym: "fucidin" EXACT [] xref: pubchem.compound:3000226 [Term] id: ARO:3000760 name: cycloserine namespace: antibiotic_resistance def: "Cycloserine is an anti-mycobacterial agent, and is active against enterobacteria, streptococci, M. tuberculosis, Staphylococcus aureus, and many Gram-negative and Gram-positive bacteria. It inhibits cell wall biosynthesis." [PMID:4555420, PMID:14479178] is_a: ARO:3007154 ! cycloserine-like antibiotic xref: pubchem.compound:6234 [Term] id: ARO:3000761 name: mecillinam namespace: antibiotic_resistance def: "Mecillinam is a broad-spectrum beta-lactam antibiotic that was semi-synthetically derived to have a different drug centre, being a 6-alpha-amidinopenicillanate instead of a 6-alpha-acylaminopenicillanate. Contrasting most beta-lactam drugs, mecillinam is most active against Gram-negative bacteria. It binds specifically to penicillin binding protein 2 (PBP2)." [PMID:6310995] is_a: ARO:3000008 ! penam synonym: "Selexid" EXACT [] synonym: "Selexidin" EXACT [] synonym: "amdinocillin" EXACT [] xref: pubchem.compound:36273 [Term] id: ARO:3000762 name: pefloxacin namespace: antibiotic_resistance def: "Pefloxacin is structurally and functionally similar to norfloxacin. It is poorly active against mycobacteria, while anaerobes are resistant." [PMID:2663414] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:51081 [Term] id: ARO:3000763 name: antibiotic sensitive embC namespace: antibiotic_resistance def: "EmbC is an arabinosyltransferase involved in lipoarabinomannan synthesis." [PMID:18174142] is_a: ARO:3000725 ! antibiotic sensitive aftA relationship: targeted_by_antibiotic ARO:3000497 ! ethambutol [Term] id: ARO:3000764 name: antibiotic sensitive embA namespace: antibiotic_resistance def: "EmbA is an arabinosyltransferase that works as a heterodimer with EmbB. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall." [PMID:18174142] is_a: ARO:3000725 ! antibiotic sensitive aftA relationship: targeted_by_antibiotic ARO:3000497 ! ethambutol [Term] id: ARO:3000765 name: antibiotic sensitive embB namespace: antibiotic_resistance def: "EmbB is an arabinosyltransferase that works as a heterodimer with EmbA. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall." [PMID:18174142] is_a: ARO:3000725 ! antibiotic sensitive aftA relationship: targeted_by_antibiotic ARO:3000497 ! ethambutol [Term] id: ARO:3000766 name: antibiotic sensitive topoisomerase subunit namespace: antibiotic_resistance def: "Topoisomerases are responsible for winding and relaxing supercoiled DNA. The subunits of gyrase (gyrA, gyrB) and topoisomerase IV (parC, parE, parY) are targeted by antibiotics." [] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic [Term] id: ARO:3000767 name: avoparcin namespace: antibiotic_resistance def: "Avoparcin is a glycopeptide antibiotic that is an analog of vancomycin. It was formally used to treat animals, but has since been banned because of its selection for vancomycin-resistant enterococci." [PMID:2532132, PMID:9458981] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:16132294 [Term] id: ARO:3000768 name: abeS namespace: antibiotic_resistance def: "AbeS in an efflux pump of the SMR family of transporters found in Acinetobacter baumannii." [PMID:19770280] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin synonym: "abeS" EXACT CARD_Short_Name [] [Term] id: ARO:3000769 name: PatA-PatB namespace: antibiotic_resistance def: "PatA-PatB is an efflux protein complex that is associated with fluoroquinolone resistance in Streptococcus pneumoniae. Experiments indicate that PatA and PatB form a heterodimeric transporter." [PMID:20709735, PMID:20937787] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "PatA-PatB" EXACT CARD_Short_Name [] synonym: "PatA/PatB" EXACT [] synonym: "PatAB" EXACT [] [Term] id: ARO:3000770 name: AdeABC namespace: antibiotic_resistance def: "AdeABC is an RND multidrug efflux system in Acinetobacter species, notably A. baunmannii. AdeA is a membrane fusion protein, AdeB is the inner membrane transporter, and AdeC is the outer membrane factor. It confers resistance to tigecycline." [PMID:17363424, PMID:21173183] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline [Term] id: ARO:3000771 name: AdeFGH namespace: antibiotic_resistance def: "AdeFGH is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It confers resistance to fluoroquinolone, tetracycline, tigecycline, chloramphenicol, clindamycin, trimethoprim, and sulfamethoxazole." [PMID:20696879, PMID:21377839] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic [Term] id: ARO:3000772 name: AdeIJK namespace: antibiotic_resistance def: "AdeIJK is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It contributes to resistance for beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolone, fusidic acid, novobiocin, rifampicin, trimethoprim, acridine, pyronine, and safranin." [PMID:18086852] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3000773 name: CmeABC namespace: antibiotic_resistance def: "CmeABC is a multidrug efflux pump in Campylobacter jejuni. Its overexpression led to enhanced resistance to ciprofloxacin, norfloxacin, cefotaxime, fusidic acid, and erythromycin. CmeA acts as the periplasmic fusion protein, CmeB is the inner membrane transporter, and CmeC is an outer membrane protein." [PMID:15728904, PMID:27651364] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3000759 ! fusidic acid relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic [Term] id: ARO:3000774 name: adeA namespace: antibiotic_resistance def: "AdeA is the membrane fusion protein of the multidrug efflux complex AdeABC." [PMID:21173183] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000770 ! AdeABC synonym: "adeA" EXACT CARD_Short_Name [] [Term] id: ARO:3000775 name: adeB namespace: antibiotic_resistance def: "AdeB is the multidrug transporter of the adeABC efflux system." [PMID:21173183] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000770 ! AdeABC synonym: "adeB" EXACT CARD_Short_Name [] [Term] id: ARO:3000777 name: adeF namespace: antibiotic_resistance def: "AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH." [PMID:20696879] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000771 ! AdeFGH synonym: "adeF" EXACT CARD_Short_Name [] [Term] id: ARO:3000778 name: adeG namespace: antibiotic_resistance def: "AdeG is the inner membrane transporter of the AdeFGH multidrug efflux complex." [PMID:21377839] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000771 ! AdeFGH synonym: "adeG" EXACT CARD_Short_Name [] [Term] id: ARO:3000779 name: adeH namespace: antibiotic_resistance def: "AdeH is the outer membrane channel protein of the AdeFGH multidrug efflux complex." [PMID:20696879] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000771 ! AdeFGH synonym: "adeH" EXACT CARD_Short_Name [] [Term] id: ARO:3000780 name: adeI namespace: antibiotic_resistance def: "AdeI is the membrane fusion protein of the AdeIJK multidrug efflux complex." [PMID:18086852] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000772 ! AdeIJK synonym: "adeI" EXACT CARD_Short_Name [] [Term] id: ARO:3000781 name: adeJ namespace: antibiotic_resistance def: "AdeJ is a RND efflux protein that acts as the inner membrane transporter of the AdeIJK efflux complex. It has 57% identity with E. coli AcrB." [PMID:18086852] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000772 ! AdeIJK synonym: "adeJ" EXACT CARD_Short_Name [] [Term] id: ARO:3000782 name: adeK namespace: antibiotic_resistance def: "AdeK is the outer membrane factor protein in the adeIJK multidrug efflux complex." [PMID:18086852] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000772 ! AdeIJK synonym: "adeK" EXACT CARD_Short_Name [] [Term] id: ARO:3000783 name: cmeA namespace: antibiotic_resistance def: "CmeA is the membrane fusion protein of the CmeABC multidrug efflux complex." [PMID:15728904] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000773 ! CmeABC synonym: "cmeA" EXACT CARD_Short_Name [] [Term] id: ARO:3000784 name: cmeB namespace: antibiotic_resistance def: "CmeB is the inner membrane transporter the CmeABC multidrug efflux complex." [PMID:15728904] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000773 ! CmeABC synonym: "cmeB" EXACT CARD_Short_Name [] [Term] id: ARO:3000785 name: cmeC namespace: antibiotic_resistance def: "CmeC is the outer membrane channel protein of the CmeABC multidrug efflux complex." [PMID:15728904] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000773 ! CmeABC synonym: "cmeC" EXACT CARD_Short_Name [] [Term] id: ARO:3000786 name: MdsABC namespace: antibiotic_resistance def: "MdsABC, or GesABC, is a RND-type efflux complex found in Salmonella. In addition to its metal-efflux system, GesABC is also capable of exporting beta-lactams, chloramphenicol, and thiamphenicol. GesB is the inner membrane transporter and is similar to MexF; GesA is the membrane-fusion protein, and GesC is the outer membrane factor." [PMID:17919284, PMID:20497225] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem synonym: "GesABC" EXACT [] synonym: "STM0352 STM0351 STM0350" EXACT [] [Term] id: ARO:3000787 name: MdtABC-TolC namespace: antibiotic_resistance def: "MdtABC-TolC is a multidrug efflux system in Gram-negative bacteria, including E. coli and Salmonella. MdtA is a membrane fusion protein; TolC is the outer membrane channel; MdtBC form a drug transporter. In the absence of MdtB, the MdtAC-TolC has narrower drug specificity, leading to the loss of novobiocin resistance, for example." [PMID:12107133, PMID:17933888] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin synonym: "MdtABC-TolC" EXACT CARD_Short_Name [] [Term] id: ARO:3000788 name: MdtEF-TolC namespace: antibiotic_resistance def: "MdtEF-TolC is a multidrug efflux complex in Gram-negative bacteria, including E. coli. MdtE is the membrane fusion protein, MdtF is the inner membrane transporter, while TolC is the outer membrane channel." [PMID:14973023] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000011 ! cloxacillin relationship: confers_resistance_to_antibiotic ARO:0000056 ! oxacillin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "MdtEF-TolC" EXACT CARD_Short_Name [] synonym: "YhiUV-TolC" EXACT [] [Term] id: ARO:3000789 name: mdsA namespace: antibiotic_resistance def: "MdsA is the membrane fusion protein of the multidrug and metal efflux complex MdsABC." [PMID:17919284, PMID:20497225] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000786 ! MdsABC synonym: "gesA" EXACT [] synonym: "mdsA" EXACT CARD_Short_Name [] [Term] id: ARO:3000790 name: mdsB namespace: antibiotic_resistance def: "MdsB is the inner membrane transporter of the multidrug and metal efflux complex MdsABC. mdsB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 (gene name: mexQ) and 2 loci in Pseudomonas aeruginosa LESB58." [PMID:20497225, PMID:17919284] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000786 ! MdsABC synonym: "gesB" EXACT [] synonym: "mdsB" EXACT CARD_Short_Name [] [Term] id: ARO:3000791 name: mdsC namespace: antibiotic_resistance def: "MdsC is the outer membrane channel of the multidrug and metal efflux complex MdsABC." [PMID:17919284, PMID:20497225] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000786 ! MdsABC synonym: "gesC" EXACT [] synonym: "mdsC" EXACT CARD_Short_Name [] [Term] id: ARO:3000792 name: mdtA namespace: antibiotic_resistance def: "MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC." [PMID:12107133] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000787 ! MdtABC-TolC synonym: "mdtA" EXACT CARD_Short_Name [] synonym: "yegM" EXACT [] [Term] id: ARO:3000793 name: mdtB namespace: antibiotic_resistance def: "MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex." [PMID:12107133] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000787 ! MdtABC-TolC synonym: "mdtB" EXACT CARD_Short_Name [] synonym: "yegN" EXACT [] [Term] id: ARO:3000794 name: mdtC namespace: antibiotic_resistance def: "MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58." [PMID:12107133] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000787 ! MdtABC-TolC synonym: "mdtC" EXACT CARD_Short_Name [] synonym: "yegO" EXACT [] [Term] id: ARO:3000795 name: mdtE namespace: antibiotic_resistance def: "MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA." [PMID:23380871] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000788 ! MdtEF-TolC synonym: "YhiU" EXACT [] synonym: "mdtE" EXACT CARD_Short_Name [] [Term] id: ARO:3000796 name: mdtF namespace: antibiotic_resistance def: "MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex." [PMID:11914367] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000788 ! MdtEF-TolC synonym: "YhiV" EXACT [] synonym: "mdtF" EXACT CARD_Short_Name [] [Term] id: ARO:3000797 name: MexCD-OprJ namespace: antibiotic_resistance def: "MexCD-OprJ is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexC is the membrane fusion protein; MexD is the inner membrane transporter; and OprJ is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, and macrolides. MexCD-OprJ is typically quiescent in wild-type cells, with expression following mutation of the nfxB gene that is divergently transcribed from the mexCD-oprJ operon and encodes a repressor of mexCD-oprJ expression. Expression of mexCD–oprJ is controlled by a single known regulator, the NfxB repressor encoded by the nfxB gene, which is transcribed divergently from the efflux genes." [PMID:9449262] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3000798 name: MexEF-OprN namespace: antibiotic_resistance def: "MexEF-OprN is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexE is the membrane fusion protein; MexF is the inner membrane transporter; and OprN is the outer membrane channel. MexEF-OprN is associated with resistance to fluoroquinolones, chloramphenicol, and trimethoprim. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. MexEF-OprN is the only positively regulated RND pump of P. aeruginosa." [PMID:10515918] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "NfxC mutant" EXACT [] [Term] id: ARO:3000799 name: MexGHI-OpmD namespace: antibiotic_resistance def: "MexGHI-OpmD is an efflux complex expressed in Pseudomonas aeruginosa. MexG is a membrane protein required for drug export; MexH is the membrane fusion protein; MexI is the inner membrane transporter; and MexJ is the outer membrane channel protein. MexGHI-OpmD confers resistance to vanadium, norfloxacin, and acriflavin." [PMID:15817779, PMID:12917802] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "MexGHI-OmpD" EXACT [] synonym: "MexGHI-OpmD" EXACT CARD_Short_Name [] [Term] id: ARO:3000800 name: MexC namespace: antibiotic_resistance def: "MexC is the membrane fusion protein of the MexCD-OprJ multidrug efflux complex." [PMID:9449262] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000797 ! MexCD-OprJ relationship: part_of ARO:3004061 ! MexCD-OprJ with type A NfxB mutation relationship: part_of ARO:3004062 ! MexCD-OprJ with type B NfxB mutation synonym: "MexC" EXACT CARD_Short_Name [] [Term] id: ARO:3000801 name: MexD namespace: antibiotic_resistance def: "MexD is the multidrug inner membrane transporter of the MexCD-OprJ complex." [PMID:8878035, PMID:9449262] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000797 ! MexCD-OprJ relationship: part_of ARO:3004061 ! MexCD-OprJ with type A NfxB mutation relationship: part_of ARO:3004062 ! MexCD-OprJ with type B NfxB mutation synonym: "MexD" EXACT CARD_Short_Name [] [Term] id: ARO:3000802 name: OprJ namespace: antibiotic_resistance def: "OprJ is the outer membrane channel component of the MexCD-OprJ multidrug efflux complex." [PMID:9449262] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000797 ! MexCD-OprJ relationship: part_of ARO:3004061 ! MexCD-OprJ with type A NfxB mutation relationship: part_of ARO:3004062 ! MexCD-OprJ with type B NfxB mutation synonym: "OprJ" EXACT CARD_Short_Name [] [Term] id: ARO:3000803 name: MexE namespace: antibiotic_resistance def: "MexE is the membrane fusion protein of the MexEF-OprN multidrug efflux complex." [PMID:10515918] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000798 ! MexEF-OprN relationship: part_of ARO:3004066 ! MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: part_of ARO:3004068 ! MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: part_of ARO:3004070 ! MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin synonym: "MexE" EXACT CARD_Short_Name [] [Term] id: ARO:3000804 name: MexF namespace: antibiotic_resistance def: "MexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB)." [PMID:10515918] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000798 ! MexEF-OprN relationship: part_of ARO:3004066 ! MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: part_of ARO:3004068 ! MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: part_of ARO:3004070 ! MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin synonym: "MexF" EXACT CARD_Short_Name [] [Term] id: ARO:3000805 name: OprN namespace: antibiotic_resistance def: "OprN is the outer membrane channel component of the MexEF-OprN multidrug efflux complex." [PMID:10515918] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000798 ! MexEF-OprN relationship: part_of ARO:3004066 ! MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: part_of ARO:3004068 ! MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: part_of ARO:3004070 ! MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin synonym: "OprN" EXACT CARD_Short_Name [] [Term] id: ARO:3000806 name: MexG namespace: antibiotic_resistance def: "MexG is a membrane protein required for MexGHI-OpmD efflux activity." [PMID:12917802, PMID:15817779] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000799 ! MexGHI-OpmD synonym: "MexG" EXACT CARD_Short_Name [] [Term] id: ARO:3000807 name: MexH namespace: antibiotic_resistance def: "MexH is the membrane fusion protein of the efflux complex MexGHI-OpmD." [PMID:12917802, PMID:15817779] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000799 ! MexGHI-OpmD synonym: "MexH" EXACT CARD_Short_Name [] [Term] id: ARO:3000808 name: MexI namespace: antibiotic_resistance def: "MexI is the inner membrane transporter of the efflux complex MexGHI-OpmD." [PMID:15817779, PMID:12917802] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000799 ! MexGHI-OpmD synonym: "MexI" EXACT CARD_Short_Name [] [Term] id: ARO:3000809 name: OpmD namespace: antibiotic_resistance def: "OpmD is the outer membrane channel protein of the efflux complex MexGHI-OpmD." [PMID:12917802, PMID:12177331, PMID:12937010, PMID:15817779] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000799 ! MexGHI-OpmD synonym: "OpmD" EXACT CARD_Short_Name [] synonym: "ompD" EXACT [] [Term] id: ARO:3000810 name: mtrC namespace: antibiotic_resistance def: "MtrC is the membrane fusion protein of the MtrCDE multidrug efflux complex." [PMID:14500476] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000369 ! MtrCDE synonym: "mtrC" EXACT CARD_Short_Name [] [Term] id: ARO:3000811 name: mtrD namespace: antibiotic_resistance def: "MtrD is the inner membrane multidrug transporter of the MtrCDE efflux complex." [PMID:14500476, PMID:9245801] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000369 ! MtrCDE synonym: "mtrD" EXACT CARD_Short_Name [] [Term] id: ARO:3000812 name: mtrE namespace: antibiotic_resistance def: "MtrE is an outer membrane exporter protein that is part of the MtrCDE multidrug efflux complex." [PMID:14500476] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000369 ! MtrCDE synonym: "mtrE" EXACT CARD_Short_Name [] [Term] id: ARO:3000813 name: MexS namespace: antibiotic_resistance def: "MexS is a suppressor of MexT, which is an activator of the multidrug pump MexEF-OprN. Mutations in MexS lead to multidrug resistance." [PMID:15687188, PMID:26833155, PMID:11040437] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004068 ! MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: regulates ARO:3000798 ! MexEF-OprN synonym: "MexS" EXACT CARD_Short_Name [] synonym: "PA2491" EXACT [] synonym: "nfxC" EXACT [] synonym: "qrh" EXACT [] [Term] id: ARO:3000814 name: MexT namespace: antibiotic_resistance def: "MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN, OprD, and MexS." [PMID:26833155, PMID:11040437, PMID:10515918] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004066 ! MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: part_of ARO:3004068 ! MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim relationship: regulates ARO:3000798 ! MexEF-OprN synonym: "MexT" EXACT CARD_Short_Name [] [Term] id: ARO:3000815 name: mgrA namespace: antibiotic_resistance def: "MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38." [PMID:12730173, PMID:15774883] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000391 ! norA relationship: regulates ARO:3000421 ! norB relationship: regulates ARO:3000565 ! tet(38) relationship: regulates ARO:3003942 ! abcA synonym: "mgrA" EXACT CARD_Short_Name [] synonym: "norR" EXACT [] [Term] id: ARO:3000816 name: mtrA namespace: antibiotic_resistance def: "MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae." [PMID:10417654] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000369 ! MtrCDE synonym: "mtrA" EXACT CARD_Short_Name [] [Term] id: ARO:3000817 name: mtrR namespace: antibiotic_resistance def: "MtrR is a repressor of mtrCDE expression. Mutations in mtrR increase multidrug resistance." [PMID:7773394] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000369 ! MtrCDE relationship: regulates ARO:3003960 ! farAB synonym: "mtrR" EXACT CARD_Short_Name [] [Term] id: ARO:3000818 name: nalC namespace: antibiotic_resistance def: "NalC is a repressor of PA3720-PA3719, which are positive regulators of MexAB-OprM. Thus, nalC mutants confer multidrug resistance." [PMID:27412168, PMID:15387820, PMID:27060003] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004051 ! MexAB-OprM with NalC mutations conferring resistance to aztreonam relationship: regulates ARO:3000386 ! MexAB-OprM synonym: "PA3721" EXACT [] synonym: "nalC" EXACT CARD_Short_Name [] [Term] id: ARO:3000819 name: nalD namespace: antibiotic_resistance def: "NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression." [PMID:15855496] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004052 ! MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics relationship: regulates ARO:3000386 ! MexAB-OprM synonym: "PA3574" EXACT [] synonym: "nalD" EXACT CARD_Short_Name [] [Term] id: ARO:3000820 name: NfxB namespace: antibiotic_resistance def: "NfxB is a repressor of the efflux pump mexCD-oprJ and itself (NfxB binds upstream of the nfxB gene and negatively regulates its own expression). Increased expression of MexCD–OprJ brought about by mutations in NfxB." [PMID:1330820, PMID:23924707, PMID:12727072, PMID:8878035] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000797 ! MexCD-OprJ [Term] id: ARO:3000821 name: phoPQ namespace: antibiotic_resistance def: "PhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species." [PMID:21131322, PMID:11222580, PMID:16359323, PMID:20843473] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: regulates ARO:3000545 ! MacAB-TolC relationship: regulates ARO:3002985 ! arnA relationship: regulates ARO:3003579 ! basRS relationship: regulates ARO:3003820 ! mgrB synonym: "PhoP/Q" EXACT [] [Term] id: ARO:3000822 name: pmrA namespace: antibiotic_resistance def: "PmrA is a MFS-type efflux pump expressed in Streptococcus pneumoniae that confers low-level resistance to norfloxacin, ciprofloxacin, and acriflavine." [PMID:11850265, PMID:9869592, PMID:20709735, PMID:15205413] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "pmrA" EXACT CARD_Short_Name [] [Term] id: ARO:3000823 name: ramA namespace: antibiotic_resistance def: "RamA (resistance antibiotic multiple) is a positive regulator of AcrAB-TolC and leads to high level multidrug resistance in Klebsiella pneumoniae, Salmonella enterica, and Enterobacter aerugenes, increasing the expression of both the mar operon as well as AcrAB. RamA also decreases OmpF expression." [PMID:15215103, PMID:7551053, PMID:12936981, PMID:18577510] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000265 ! porin OmpF relationship: regulates ARO:3000384 ! AcrAB-TolC synonym: "ramA" EXACT CARD_Short_Name [] [Term] id: ARO:3000824 name: ramR namespace: antibiotic_resistance def: "RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA." [PMID:19104017, PMID:18443112, PMID:19778917, PMID:19270312] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000384 ! AcrAB-TolC [Term] id: ARO:3000825 name: rob namespace: antibiotic_resistance def: "The robA protein is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA." [PMID:12791142, PMID:9324261] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000384 ! AcrAB-TolC synonym: "robA" EXACT [] [Term] id: ARO:3000826 name: sdiA namespace: antibiotic_resistance def: "SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB." [PMID:11929524, PMID:20126629] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000384 ! AcrAB-TolC synonym: "sdiA" EXACT CARD_Short_Name [] [Term] id: ARO:3000827 name: soxRS namespace: antibiotic_resistance def: "SoxRS is a two-component regulator part of the superoxide stress response. It is a positive regulator for many multidrug efflux pumps." [PMID:7986007] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000384 ! AcrAB-TolC relationship: regulates ARO:3000448 ! QepA1 relationship: regulates ARO:3000769 ! PatA-PatB [Term] id: ARO:3000828 name: baeR namespace: antibiotic_resistance def: "BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes." [PMID:12107133, PMID:37345941] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000531 ! baeSR synonym: "baeR" EXACT CARD_Short_Name [] [Term] id: ARO:3000829 name: baeS namespace: antibiotic_resistance def: "BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance." [PMID:15716448, PMID:37345941, PMID:12107134] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000531 ! baeSR synonym: "baeS" EXACT CARD_Short_Name [] [Term] id: ARO:3000830 name: cpxA namespace: antibiotic_resistance def: "CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression." [PMID:22496764] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000524 ! cpxAR synonym: "cpxA" EXACT CARD_Short_Name [] [Term] id: ARO:3000831 name: CpxR namespace: antibiotic_resistance def: "CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA, a sensor kinase. CpxR is also directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR." [PMID:22496764, PMID:25294881, PMID:27736975] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000524 ! cpxAR relationship: regulates ARO:3000386 ! MexAB-OprM [Term] id: ARO:3000832 name: evgA namespace: antibiotic_resistance def: "EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed." [PMID:12951338] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000515 ! evgSA synonym: "evgA" EXACT CARD_Short_Name [] [Term] id: ARO:3000833 name: evgS namespace: antibiotic_resistance def: "EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58." [PMID:11914367] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000515 ! evgSA synonym: "evgS" EXACT CARD_Short_Name [] synonym: "rocS1" EXACT [] [Term] id: ARO:3000834 name: phoP namespace: antibiotic_resistance def: "PhoP is a direct repressor of the macAB efflux genes." [PMID:24412662] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000821 ! phoPQ [Term] id: ARO:3000835 name: phoQ namespace: antibiotic_resistance def: "PhoQ is a sensor protein that is induced by low Mg2+ concentrations. When activated, PhoQ donates a phosphate to activate PhoP." [PMID:24412662] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000821 ! phoPQ [Term] id: ARO:3000836 name: soxR namespace: antibiotic_resistance def: "SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. In Pseudomonas aeruginosa, which lacks SoxS, SoxR is able to directly upregulate the expression of the MexGHI-OpmD efflux pump." [PMID:21226770, PMID:15845502] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance relationship: part_of ARO:3000827 ! soxRS [Term] id: ARO:3000837 name: soxS namespace: antibiotic_resistance def: "SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability." [PMID:15845502, PMID:9324261, PMID:7986007, PMID:8821940] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance relationship: part_of ARO:3000827 ! soxRS relationship: regulates ARO:3000265 ! porin OmpF [Term] id: ARO:3000838 name: arlR namespace: antibiotic_resistance def: "ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS." [PMID:10633099] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3000547 ! arlRS synonym: "arlR" EXACT CARD_Short_Name [] [Term] id: ARO:3000839 name: arlS namespace: antibiotic_resistance def: "ArlS is a protein histidine kinase that phosphorylates ArlR, a promoter for norA expression." [PMID:10633099] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000547 ! arlRS synonym: "arlS" EXACT CARD_Short_Name [] [Term] id: ARO:3000840 name: JOHN-1 namespace: antibiotic_resistance def: "JOHN-1 is an Ambler class B carbapenem-hydrolysing beta-lactamase from Flavobacterium johnsoniae." [PMID:12562690] is_a: ARO:3004202 ! JOHN beta-lactamase synonym: "JOHN-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000841 name: CGB-1 namespace: antibiotic_resistance def: "CGB-1 is an Ambler class B beta-lactamase that mediates resistance for carbapenems in Chryseobacterium gleum." [PMID:12183230] is_a: ARO:3004203 ! CGB beta-lactamase synonym: "CGB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000842 name: EBR-1 namespace: antibiotic_resistance def: "EBR-1 is an Ambler class B beta-lactamase found in Empedobacter brevis and is known to mediate the hydrolysis of penicillins, cephalosporins, and carbapenems efficiently but not aztreonam." [PMID:12234848] is_a: ARO:3004204 ! EBR beta-lactamase synonym: "EBR-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000843 name: MUS-1 namespace: antibiotic_resistance def: "MUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus." [PMID:12384365] is_a: ARO:3004067 ! MUS beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "MUS-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000844 name: TUS-1 namespace: antibiotic_resistance def: "TUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus." [PMID:12384365] is_a: ARO:3004205 ! TUS beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "TUS-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000845 name: GIM-1 namespace: antibiotic_resistance def: "GIM-1 is an integron-encoded B1 beta-lactamase found in Pseudomonas aeruginosa." [PMID:15561840] is_a: ARO:3003195 ! GIM beta-lactamase synonym: "GIM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000846 name: SIM-1 namespace: antibiotic_resistance def: "SIM-1 is an integron-encoded Ambler class B beta-lactamase isolated from Acinetobacter baumannii." [PMID:16251286] is_a: ARO:3004206 ! SIM beta-lactamase synonym: "SIM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000847 name: KHM-1 namespace: antibiotic_resistance def: "KHM-1 is a plasmid-mediated metallo-beta-lactamase found in Citrobacter freundii that confers resistance to all broad-spectrum beta-lactams, execpt for monobactams." [PMID:18765691] is_a: ARO:3004207 ! KHM beta-lactamase synonym: "KHM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000848 name: DIM-1 namespace: antibiotic_resistance def: "Dutch imipenemase or DIM-1 is an integron-encoded metallo-beta-lactamase from Pseudomonas stutzeri." [PMID:20308383] is_a: ARO:3004208 ! DIM beta-lactamase synonym: "DIM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000849 name: SFH-1 namespace: antibiotic_resistance def: "SFH-1 confers resistance to carbapenems in Serratia fonticola." [PMID:12821491] is_a: ARO:3004210 ! SFH beta-lactamase synonym: "SFH-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000850 name: GOB-1 namespace: antibiotic_resistance def: "GOB-1 confers resistance to cephalosporins in Elizabethkingia (Chryseobacterium) meningoseptica." [PMID:10858348] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000851 name: THIN-B namespace: antibiotic_resistance def: "THIN-B, isolated from Janthinobacterium lividum, hydrolyzes a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems." [PMID:15561856] is_a: ARO:3004214 ! THIN-B beta-lactamase synonym: "THIN-B" EXACT CARD_Short_Name [] [Term] id: ARO:3000853 name: AIM-1 namespace: antibiotic_resistance def: "AIM-1 is an Ambler class B beta-lactamase that hydrolyzes most beta-lactams except aztreonam and ceftazidime. It was isolated from Pseudomonas aeruginosa and was the first subclass B3 mobile-elements encoded beta-lactamase discovered." [PMID:22985886] is_a: ARO:3004216 ! AIM beta-lactamase synonym: "AIM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000854 name: SMB-1 namespace: antibiotic_resistance def: "SMB-1 can hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. It was identified in Serratia marcescens." [PMID:22442240] is_a: ARO:3004217 ! SMB beta-lactamase synonym: "SMB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000855 name: CAU-1 namespace: antibiotic_resistance def: "CAU-1 is a B3 metallo-beta-lactamase that is encoded by the Caulobacter crescentus chromosome." [PMID:12019096] is_a: ARO:3004218 ! CAU beta-lactamase synonym: "CAU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000856 name: BJP-1 namespace: antibiotic_resistance def: "BJP-1 is a subclass B3 ortholog found in Bradyrhizobium japonicum that hydrolyzes most beta-lactams except aztreonam, ticarcillin, and temocillin." [PMID:16723554] is_a: ARO:3004219 ! BJP beta-lactamase synonym: "BJP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3000857 name: 16S ribosomal RNA methyltransferase namespace: antibiotic_resistance def: "Methyltransferases that modify the 16S rRNA of the 30S subunit of bacterial ribosomes, conferring resistance to drugs that target 16S rRNA." [PMID:14667745, PMID:22547620, PMID:21177880] is_a: ARO:3000164 ! rRNA methyltransferase conferring antibiotic resistance [Term] id: ARO:3000858 name: armA namespace: antibiotic_resistance def: "ArmA is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site." [PMID:19303884, PMID:20926221, PMID:27885285, PMID:21177880] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3000653 ! G418 relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B synonym: "armA" EXACT CARD_Short_Name [] xref: PDB:3FZG [Term] id: ARO:3000859 name: rmtA namespace: antibiotic_resistance def: "RmtA is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides." [PMID:14667745] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3000653 ! G418 relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B synonym: "rmtA" EXACT CARD_Short_Name [] [Term] id: ARO:3000860 name: rmtB namespace: antibiotic_resistance def: "RmtB is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site." [PMID:19303884, PMID:20614151] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3000653 ! G418 relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B synonym: "rmtB" EXACT CARD_Short_Name [] xref: PDB:3FRH [Term] id: ARO:3000861 name: rmtC namespace: antibiotic_resistance def: "RmtC is a rRNA methyltransferase found in Proteus mirabilis with high level resistance to similar to aminoglycosides, with the exception of non-4,6-disubstituted deoxystreptamines (streptomycin and neomycin). It has also been isolated in Salmonella enterica ser. Virchow. It is hypothesized to methylate G1405, like related methyltransferases RmtA, RmtB, and ArmA." [PMID:16377684, PMID:20350396, PMID:21177880, PMID:26488937] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3000653 ! G418 relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B synonym: "rmtC" EXACT CARD_Short_Name [] [Term] id: ARO:3000862 name: sgm namespace: antibiotic_resistance def: "Sgm, or sisomicin-gentamicin methyltransferase, methylates G1405 of 16S rRNA to confer resistance to various aminoglycosides." [PMID:20194115] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3000653 ! G418 relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B synonym: "sgm" EXACT CARD_Short_Name [] xref: PDB:3LCV [Term] id: ARO:3000863 name: defensin resistant mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins." [PMID:20498310, PMID:19915718, PMID:14769468] is_a: ARO:3000519 ! antibiotic target modifying enzyme is_a: ARO:3003421 ! antibiotic resistant mprF relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3000864 name: fluoroquinolone resistant gyrB namespace: antibiotic_resistance def: "Point mutations in DNA gyrase subunit B (gyrB) observed in Mycobacterium tuberculosis can result in resistance to fluoroquinolones." [PMID:22279180] is_a: ARO:3000220 ! antibiotic resistant DNA topoisomerase subunit gyrB is_a: ARO:3000452 ! fluoroquinolone resistant DNA topoisomerase relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: derives_from ARO:3003261 ! fluoroquinolone sensitive gyrB [Term] id: ARO:3000865 name: oleD namespace: antibiotic_resistance def: "OleD is a glycotransferase found in Streptomyces antibioticus, a natural producer of oleandomycin. OleD can glycosylate a wide range of macrolides. Unlike oleI, oleD is not found in the oleandomycin biosynthetic cluster." [PMID:10766792, PMID:17376874, PMID:8244027] is_a: ARO:3000465 ! ole glycosyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin synonym: "oleD" EXACT CARD_Short_Name [] xref: PDB:2IYF [Term] id: ARO:3000866 name: oleI namespace: antibiotic_resistance def: "OleI is a glycosyltransferase found in Streptomyces antibioticus, specifically the oleandomycin biosynthetic cluster. OleI glycosylates oleandomycin to confer self-resistance." [PMID:17376874] is_a: ARO:3000465 ! ole glycosyltransferase relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "oleI" EXACT CARD_Short_Name [] xref: PDB:2IYA [Term] id: ARO:3000867 name: oleandomycin namespace: antibiotic_resistance def: "Oleandomycin is a 14-membered macrolide produced by Streptomyces antibioticus. It is ssimilar to erythromycin, and contains a desosamine amino sugar and an oleandrose sugar. It targets the 50S ribosomal subunit to prevent protein synthesis." [] is_a: ARO:0000000 ! macrolide antibiotic synonym: "Amimycin" EXACT [] synonym: "Matromycin" EXACT [] xref: pubchem.compound:72493 [Term] id: ARO:3000869 name: streptothricin acetyltransferase (SAT) namespace: antibiotic_resistance def: "AcetylCoA dependent acetyltransferase that acetylate streptothricins such as nourseothricin at position 16 (beta position of beta-lysine)." [PMID:8394835, PMID:3624064] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000034 ! nucleoside antibiotic relationship: participates_in ARO:3000106 ! acylation of antibiotic conferring resistance [Term] id: ARO:3000870 name: triclosan namespace: antibiotic_resistance def: "Triclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI)." [PMID:19768684, PMID:10196195] is_a: ARO:3005386 ! disinfecting agents and antiseptics xref: pubchem.compound:5564 [Term] id: ARO:3000871 name: fatty acid synthesis enzyme targeted by antibiotic namespace: antibiotic_resistance def: "Antibiotics can target bacteria-specific fatty acid biosynthesis enzymes." [PMID:14736233] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3000872 name: antibiotic sensitive enoyl-acyl carrier reductase namespace: antibiotic_resistance def: "Enoyl-acyl carrier reductases catalyze the final enoyl reduction step in bacterial type II fatty acid elongation. Triclosan antibiotics block enoyl reduction and therefore fatty acid synthesis, functioning as a broad spectrum biocide and antibiotic." [PMID:14736233] is_a: ARO:3000871 ! fatty acid synthesis enzyme targeted by antibiotic relationship: targeted_by_antibiotic ARO:3000870 ! triclosan [Term] id: ARO:3000873 name: TEM-1 namespace: antibiotic_resistance def: "TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins." [PMID:33416461, PMID:20412308, PMID:358200, PMID:5326330] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "RTEM-1" EXACT [] synonym: "TEM-1" EXACT CARD_Short_Name [] synonym: "TEM-1B" EXACT [] [Term] id: ARO:3000874 name: TEM-2 namespace: antibiotic_resistance def: "TEM-2 is a broad-spectrum beta-lactamase." [PMID:358199, PMID:1107329] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3000875 name: TEM-3 namespace: antibiotic_resistance def: "TEM-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:3316146, PMID:2550326] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CTX-1" EXACT [] synonym: "TEM-14" EXACT [] synonym: "TEM-3" EXACT CARD_Short_Name [] [Term] id: ARO:3000876 name: TEM-4 namespace: antibiotic_resistance def: "TEM-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:2692515, PMID:2550326] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-4" EXACT CARD_Short_Name [] [Term] id: ARO:3000877 name: TEM-5 namespace: antibiotic_resistance def: "TEM-5 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:3293523, PMID:2550326] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CAZ-1" EXACT [] synonym: "TEM-5" EXACT CARD_Short_Name [] [Term] id: ARO:3000878 name: TEM-6 namespace: antibiotic_resistance def: "TEM-6 is an extended-spectrum beta-lactamase found in E. coli." [PMID:3312022] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-6" EXACT CARD_Short_Name [] [Term] id: ARO:3000879 name: TEM-7 namespace: antibiotic_resistance def: "TEM-7 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:2506109, PMID:3055178] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-7" EXACT CARD_Short_Name [] [Term] id: ARO:3000880 name: TEM-8 namespace: antibiotic_resistance def: "TEM-8 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:2558614, PMID:1416873, PMID:9925535] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CAZ-2" EXACT [] synonym: "TEM-8" EXACT CARD_Short_Name [] [Term] id: ARO:3000881 name: TEM-9 namespace: antibiotic_resistance def: "TEM-9 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:3312022, PMID:3326875] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "RHH-1" EXACT [] synonym: "TEM-9" EXACT CARD_Short_Name [] [Term] id: ARO:3000882 name: TEM-10 namespace: antibiotic_resistance def: "TEM-10 is an extended-spectrum beta-lactamase round in Morganella morganii." [PMID:8109951, PMID:9925535, PMID:2684007] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "MGH-1" EXACT [] synonym: "TEM-10" EXACT CARD_Short_Name [] synonym: "TEM-23" EXACT [] synonym: "TEM-E3" EXACT [] [Term] id: ARO:3000883 name: TEM-11 namespace: antibiotic_resistance def: "TEM-11 is an extended-spectrum beta-lactamase found in Proteus mirabilis." [PMID:2665644, PMID:9925535] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CAZ-lo" EXACT [] synonym: "TEM-11" EXACT CARD_Short_Name [] [Term] id: ARO:3000884 name: TEM-12 namespace: antibiotic_resistance def: "TEM-12 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca." [PMID:7840586, PMID:2197339, PMID:9925535] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CAZ-3" EXACT [] synonym: "TEM-12" EXACT CARD_Short_Name [] synonym: "TEM-26b" EXACT [] synonym: "TEM-E2" EXACT [] synonym: "YOU-2" EXACT [] [Term] id: ARO:3000885 name: TEM-13 namespace: antibiotic_resistance def: "TEM-13 is a broad-spectrum beta-lactamase that has been found in clinical isolates." [PMID:9925535] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3000886 name: TEM-15 namespace: antibiotic_resistance def: "TEM-15 is an extended-spectrum beta-lactamase that has been found in Haemophilus parainfluenzae." [PMID:9925535, PMID:10681352] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-15" EXACT CARD_Short_Name [] [Term] id: ARO:3000887 name: TEM-16 namespace: antibiotic_resistance def: "TEM-16 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:3055178, PMID:1416873] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CAZ-7" EXACT [] synonym: "TEM-16" EXACT CARD_Short_Name [] [Term] id: ARO:3000888 name: TEM-17 namespace: antibiotic_resistance def: "TEM-17 is an extended-spectrum beta-lactamase found in Capnocytophaga ochracea." [PMID:10681352] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-17" EXACT CARD_Short_Name [] [Term] id: ARO:3000889 name: TEM-18 namespace: antibiotic_resistance def: "TEM-18 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:2558614] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3000890 name: TEM-19 namespace: antibiotic_resistance def: "TEM-19 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:2073111] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-19" EXACT CARD_Short_Name [] [Term] id: ARO:3000891 name: TEM-20 namespace: antibiotic_resistance def: "TEM-20 is an extended-spectrum beta-lactamase found in several species of Gram-negative bacteria." [PMID:8586268, PMID:10103213, PMID:2184088] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-20" EXACT CARD_Short_Name [] [Term] id: ARO:3000892 name: TEM-21 namespace: antibiotic_resistance def: "TEM-21 is an extended-spectrum beta-lactamase found in many species of Gram-negative bacteria." [PMID:9687421, PMID:8586268, PMID:10103213, PMID:2184088] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-21" EXACT CARD_Short_Name [] [Term] id: ARO:3000893 name: TEM-22 namespace: antibiotic_resistance def: "TEM-22 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:8239625, PMID:10103213] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-22" EXACT CARD_Short_Name [] [Term] id: ARO:3000894 name: TEM-24 namespace: antibiotic_resistance def: "TEM-24 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:9925535, PMID:2558614, PMID:1416873] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CAZ-6" EXACT [] synonym: "TEM-24" EXACT CARD_Short_Name [] [Term] id: ARO:3000895 name: TEM-25 namespace: antibiotic_resistance def: "TEM-25 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:7840586, PMID:1929316] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "CTX-2" EXACT [] [Term] id: ARO:3000896 name: TEM-26 namespace: antibiotic_resistance def: "TEM-26 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:1416892] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-26" EXACT CARD_Short_Name [] synonym: "YOU-1" EXACT [] [Term] id: ARO:3000897 name: TEM-27 namespace: antibiotic_resistance def: "TEM-27 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:7726515] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3000898 name: TEM-28 namespace: antibiotic_resistance def: "TEM-28 is an extended-spectrum beta-lactamase found in E. coli." [PMID:8787920] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-28" EXACT CARD_Short_Name [] [Term] id: ARO:3000899 name: TEM-29 namespace: antibiotic_resistance def: "TEM-29 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:8586268] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-29" EXACT CARD_Short_Name [] [Term] id: ARO:3000900 name: TEM-30 namespace: antibiotic_resistance def: "TEM-30 is an inhibitor-resistant beta-lactamase found in E. coli. Confers resistance to amoxycilllin-clavulanic acid, ticarcillin-clavulanic acid, kanamycin, neomycin, and intermediate resistance to mezlocillin and piperacillin." [PMID:8056297, PMID:1490918, PMID:33416461] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "E-GUER" EXACT [] synonym: "IRT-2" EXACT [] synonym: "TEM-30" EXACT CARD_Short_Name [] synonym: "TRI-2" EXACT [] [Term] id: ARO:3000901 name: TEM-31 namespace: antibiotic_resistance def: "TEM-31 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:1490918, PMID:8056297] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "E-SAL" EXACT [] synonym: "IRT-1" EXACT [] synonym: "TEM-31" EXACT CARD_Short_Name [] synonym: "TRI-1" EXACT [] [Term] id: ARO:3000902 name: TEM-32 namespace: antibiotic_resistance def: "TEM-32 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:8257123] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-3" EXACT [] synonym: "TEM-32" EXACT CARD_Short_Name [] [Term] id: ARO:3000903 name: TEM-33 namespace: antibiotic_resistance def: "TEM-33 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:9925535, PMID:8067742] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-5" EXACT [] synonym: "TEM-33" EXACT CARD_Short_Name [] [Term] id: ARO:3000904 name: TEM-34 namespace: antibiotic_resistance def: "TEM-34 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:8067742] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-6" EXACT [] synonym: "TEM-34" EXACT CARD_Short_Name [] synonym: "TEM-97" EXACT [] [Term] id: ARO:3000905 name: TEM-35 namespace: antibiotic_resistance def: "TEM-35 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:8067742, PMID:25779568] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-4" EXACT [] synonym: "TEM-35" EXACT CARD_Short_Name [] [Term] id: ARO:3000906 name: TEM-36 namespace: antibiotic_resistance def: "TEM-36 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:8067742, PMID:28369408] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-7" EXACT [] synonym: "TEM-36" EXACT CARD_Short_Name [] [Term] id: ARO:3000907 name: TEM-37 namespace: antibiotic_resistance def: "TEM-37 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:7726509, PMID:26809117] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-8" EXACT [] synonym: "TEM-37" EXACT CARD_Short_Name [] [Term] id: ARO:3000908 name: TEM-38 namespace: antibiotic_resistance def: "TEM-38 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:7726509] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "IRT-9" EXACT [] [Term] id: ARO:3000909 name: TEM-39 namespace: antibiotic_resistance def: "TEM-39 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:7726509] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-10" EXACT [] synonym: "TEM-39" EXACT CARD_Short_Name [] [Term] id: ARO:3000910 name: TEM-40 namespace: antibiotic_resistance def: "TEM-40 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:8585729] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-11" EXACT [] synonym: "IRT-167" EXACT [] synonym: "TEM-40" EXACT CARD_Short_Name [] [Term] id: ARO:3000911 name: TEM-42 namespace: antibiotic_resistance def: "TEM-42 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:8913451] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-42" EXACT CARD_Short_Name [] [Term] id: ARO:3000912 name: TEM-43 namespace: antibiotic_resistance def: "TEM-43 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:9661002] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-43" EXACT CARD_Short_Name [] [Term] id: ARO:3000913 name: TEM-44 namespace: antibiotic_resistance def: "TEM-44 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:8877532] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "IRT2-2" EXACT [] synonym: "IT-13" EXACT [] [Term] id: ARO:3000914 name: TEM-45 namespace: antibiotic_resistance def: "TEM-45 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:9021194] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-14" EXACT [] synonym: "TEM-45" EXACT CARD_Short_Name [] [Term] id: ARO:3000915 name: TEM-46 namespace: antibiotic_resistance def: "TEM-46 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:9056022] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "CAZ-9" EXACT [] [Term] id: ARO:3000916 name: TEM-47 namespace: antibiotic_resistance def: "TEM-47 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:9517925] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-47" EXACT CARD_Short_Name [] [Term] id: ARO:3000917 name: TEM-48 namespace: antibiotic_resistance def: "TEM-48 is an extended-spectrum beta-lactamase found Klebsiella pneumoniae." [PMID:9517925] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-48" EXACT CARD_Short_Name [] [Term] id: ARO:3000918 name: TEM-49 namespace: antibiotic_resistance def: "TEM-49 extended-spectrum beta-lactamase found in E. coli." [PMID:9517925] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-49" EXACT CARD_Short_Name [] [Term] id: ARO:3000919 name: TEM-50 namespace: antibiotic_resistance def: "TEM-50 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:9174192] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "CMT-1" EXACT [] [Term] id: ARO:3000920 name: TEM-51 namespace: antibiotic_resistance def: "TEM-51 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:9371365] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "IRT-15" EXACT [] [Term] id: ARO:3000921 name: TEM-52 namespace: antibiotic_resistance def: "TEM-52 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae and Salmonella enterica." [PMID:9449269] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-52" EXACT CARD_Short_Name [] [Term] id: ARO:3000922 name: TEM-53 namespace: antibiotic_resistance def: "TEM-53 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:9925535] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-53" EXACT CARD_Short_Name [] [Term] id: ARO:3000923 name: TEM-54 namespace: antibiotic_resistance def: "TEM-54 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:9925535] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-54" EXACT CARD_Short_Name [] [Term] id: ARO:3000924 name: TEM-55 namespace: antibiotic_resistance def: "TEM-55 is a broad-spectrum beta-lactamase found in E. coli." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-55" EXACT CARD_Short_Name [] [Term] id: ARO:3000925 name: TEM-56 namespace: antibiotic_resistance def: "TEM-56 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:10639384] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3000926 name: TEM-57 namespace: antibiotic_resistance def: "TEM-57 is a broad-spectrum beta-lactamase found in E. coli." [PMID:10543745] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-57" EXACT CARD_Short_Name [] [Term] id: ARO:3000927 name: TEM-58 namespace: antibiotic_resistance def: "TEM-58 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:9559800] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime [Term] id: ARO:3000928 name: TEM-59 namespace: antibiotic_resistance def: "TEM-59 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:10390218] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-17" EXACT [] synonym: "TEM-59" EXACT CARD_Short_Name [] [Term] id: ARO:3000929 name: TEM-60 namespace: antibiotic_resistance def: "TEM-60 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:9624494] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-60" EXACT CARD_Short_Name [] [Term] id: ARO:3000930 name: TEM-61 namespace: antibiotic_resistance def: "TEM-61 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:2665644] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "CAZ-hi" EXACT [] synonym: "TEM-61" EXACT CARD_Short_Name [] [Term] id: ARO:3000931 name: TEM-63 namespace: antibiotic_resistance def: "TEM-63 is an extended-spectrum beta-lactamase found in E. coli." [PMID:11120950] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-63" EXACT CARD_Short_Name [] synonym: "TEM-64" EXACT [] [Term] id: ARO:3000932 name: TEM-65 namespace: antibiotic_resistance def: "TEM-65 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:10543745] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "IRT-16" EXACT [] [Term] id: ARO:3000933 name: TEM-66 namespace: antibiotic_resistance def: "TEM-66 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:10543745] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3000934 name: TEM-67 namespace: antibiotic_resistance def: "TEM-67 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis." [PMID:12499163] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-67" EXACT CARD_Short_Name [] [Term] id: ARO:3000935 name: TEM-68 namespace: antibiotic_resistance def: "TEM-68 is an inhibitor resistant, extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:10817699, PMID:12019125] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CMT-2" EXACT [] synonym: "TEM-68" EXACT CARD_Short_Name [] [Term] id: ARO:3000936 name: TEM-70 namespace: antibiotic_resistance def: "TEM-70 is a beta-lactamase found in E. coli." [PMID:23643553] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-70" EXACT CARD_Short_Name [] [Term] id: ARO:3000937 name: TEM-71 namespace: antibiotic_resistance def: "TEM-71 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:12019125] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-71" EXACT CARD_Short_Name [] [Term] id: ARO:3000938 name: TEM-72 namespace: antibiotic_resistance def: "TEM-72 is an extended-spectrum beta-lactamase found in Proteus mirabilis and Morganella morganii." [PMID:10952610] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-72" EXACT CARD_Short_Name [] [Term] id: ARO:3000939 name: TEM-73 namespace: antibiotic_resistance def: "TEM-73 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:10543745] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-18" EXACT [] synonym: "TEM-73" EXACT CARD_Short_Name [] [Term] id: ARO:3000940 name: TEM-74 namespace: antibiotic_resistance def: "TEM-74 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:10543745] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "IRT-19" EXACT [] [Term] id: ARO:3000941 name: TEM-75 namespace: antibiotic_resistance def: "TEM-75 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:10624595] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-75" EXACT CARD_Short_Name [] [Term] id: ARO:3000942 name: TEM-76 namespace: antibiotic_resistance def: "TEM-76 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:10991849] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-20" EXACT [] synonym: "TEM-76" EXACT CARD_Short_Name [] [Term] id: ARO:3000944 name: TEM-78 namespace: antibiotic_resistance def: "TEM-78 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:10991849] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-22" EXACT [] synonym: "TEM-78" EXACT CARD_Short_Name [] [Term] id: ARO:3000946 name: TEM-79 namespace: antibiotic_resistance def: "TEM-79 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:10991849] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-79" EXACT CARD_Short_Name [] [Term] id: ARO:3000947 name: TEM-80 namespace: antibiotic_resistance def: "TEM-80 is an inhibitor-resistant beta-lactamase found in Enterobacter cloacae." [PMID:11959543] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "IRT-24" EXACT [] synonym: "TEM-80" EXACT CARD_Short_Name [] [Term] id: ARO:3000948 name: TEM-81 namespace: antibiotic_resistance def: "TEM-81 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:10991849] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-81" EXACT CARD_Short_Name [] [Term] id: ARO:3000949 name: TEM-82 namespace: antibiotic_resistance def: "TEM-82 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:10991849] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-82" EXACT CARD_Short_Name [] [Term] id: ARO:3000950 name: TEM-83 namespace: antibiotic_resistance def: "TEM-83 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:10991849] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-83" EXACT CARD_Short_Name [] [Term] id: ARO:3000951 name: TEM-84 namespace: antibiotic_resistance def: "TEM-84 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:10991849] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-84" EXACT CARD_Short_Name [] [Term] id: ARO:3000952 name: TEM-85 namespace: antibiotic_resistance def: "TEM-85 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:15855509] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-85" EXACT CARD_Short_Name [] [Term] id: ARO:3000953 name: TEM-86 namespace: antibiotic_resistance def: "TEM-86 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:15855509] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-86" EXACT CARD_Short_Name [] [Term] id: ARO:3000954 name: TEM-87 namespace: antibiotic_resistance def: "TEM-87 is an extended-spectrum beta-lactamase found in Proteus mirabilis." [PMID:11850290] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-87" EXACT CARD_Short_Name [] [Term] id: ARO:3000955 name: TEM-88 namespace: antibiotic_resistance def: "TEM-88 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:11709362] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-88" EXACT CARD_Short_Name [] [Term] id: ARO:3000956 name: TEM-89 namespace: antibiotic_resistance def: "TEM-89 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:11709345] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CMT-3" EXACT [] synonym: "TEM-89" EXACT CARD_Short_Name [] [Term] id: ARO:3000957 name: TEM-90 namespace: antibiotic_resistance def: "TEM-90 is a broad-spectrum beta-lactamase found in E. coli." [PMID:11557499] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-90" EXACT CARD_Short_Name [] synonym: "TLE-1" EXACT [] [Term] id: ARO:3000958 name: TEM-91 namespace: antibiotic_resistance def: "TEM-91 is an extended-spectrum beta-lactamase found in E. coli." [PMID:12937007] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-91" EXACT CARD_Short_Name [] [Term] id: ARO:3000959 name: TEM-92 namespace: antibiotic_resistance def: "TEM-92 is an extended-spectrum beta-lactamase found in Proteus mirabilis." [PMID:11257046] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-92" EXACT CARD_Short_Name [] [Term] id: ARO:3000960 name: TEM-93 namespace: antibiotic_resistance def: "TEM-93 is an extended-spectrum beta-lactamase found in E. coli." [PMID:15855509] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-93" EXACT CARD_Short_Name [] [Term] id: ARO:3000961 name: TEM-94 namespace: antibiotic_resistance def: "TEM-94 is an extended-spectrum beta-lactamase found in E. coli." [PMID:15855509] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-94" EXACT CARD_Short_Name [] [Term] id: ARO:3000962 name: TEM-95 namespace: antibiotic_resistance def: "TEM-95 is a broad-spectrum beta-lactamase found in E. coli." [PMID:12234838] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-95" EXACT CARD_Short_Name [] [Term] id: ARO:3000963 name: TEM-96 namespace: antibiotic_resistance def: "TEM-96 is a beta-lactamase found in E. coli." [PMID:24499167] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-96" EXACT CARD_Short_Name [] [Term] id: ARO:3000964 name: TEM-101 namespace: antibiotic_resistance def: "TEM-101 is an extended-spectrum beta-lactamase found in E. coli." [PMID:3055178] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-101" EXACT CARD_Short_Name [] [Term] id: ARO:3000965 name: TEM-102 namespace: antibiotic_resistance def: "TEM-102 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:12878521] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-102" EXACT CARD_Short_Name [] [Term] id: ARO:3000966 name: TEM-103 namespace: antibiotic_resistance def: "TEM-103 is an inhibitor-resistant beta-lactamase that has been found in E. coli." [PMID:12384377] is_a: ARO:3000014 ! TEM beta-lactamase synonym: "IRT-28" EXACT [] synonym: "TEM-103" EXACT CARD_Short_Name [] [Term] id: ARO:3000967 name: TEM-104 namespace: antibiotic_resistance def: "TEM-104 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:27598630, PMID:16533535] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-104" EXACT CARD_Short_Name [] [Term] id: ARO:3000968 name: TEM-105 namespace: antibiotic_resistance def: "TEM-105 is a beta-lactamase found in E. coli." [PMID:16533535] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-105" EXACT CARD_Short_Name [] [Term] id: ARO:3000969 name: TEM-106 namespace: antibiotic_resistance def: "TEM-106 is an extended-spectrum beta-lactamase found in E. coli." [PMID:11959586] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-106" EXACT CARD_Short_Name [] [Term] id: ARO:3000970 name: TEM-107 namespace: antibiotic_resistance def: "TEM-107 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:11959586] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-107" EXACT CARD_Short_Name [] [Term] id: ARO:3000971 name: TEM-108 namespace: antibiotic_resistance def: "TEM-108 is a beta-lactamase that has been found in clinical isolates." [PMID:15297528] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-108" EXACT CARD_Short_Name [] [Term] id: ARO:3000972 name: TEM-109 namespace: antibiotic_resistance def: "TEM-109 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli." [PMID:16251281] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CMT-5" EXACT [] synonym: "TEM-109" EXACT CARD_Short_Name [] [Term] id: ARO:3000973 name: TEM-110 namespace: antibiotic_resistance def: "TEM-110 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:18292096] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-110" EXACT CARD_Short_Name [] [Term] id: ARO:3000974 name: TEM-111 namespace: antibiotic_resistance def: "TEM-111 is a beta-lactamase found in E. coli and P. mirabilis." [PMID:22450979] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-111" EXACT CARD_Short_Name [] [Term] id: ARO:3000975 name: TEM-112 namespace: antibiotic_resistance def: "TEM-112 is an extended-spectrum beta-lactamase found in E. coli." [PMID:15282240] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-112" EXACT CARD_Short_Name [] [Term] id: ARO:3000976 name: TEM-113 namespace: antibiotic_resistance def: "TEM-113 is an extended-spectrum beta-lactamase found in Proteus mirabilis." [PMID:15282240] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-113" EXACT CARD_Short_Name [] [Term] id: ARO:3000977 name: TEM-114 namespace: antibiotic_resistance def: "TEM-114 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes." [PMID:15282240] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-114" EXACT CARD_Short_Name [] [Term] id: ARO:3000978 name: TEM-115 namespace: antibiotic_resistance def: "TEM-115 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:15047521] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-115" EXACT CARD_Short_Name [] [Term] id: ARO:3000979 name: TEM-116 namespace: antibiotic_resistance def: "TEM-116 is a broad-spectrum beta-lactamase found in many species of bacteria." [PMID:15243036] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-116" EXACT CARD_Short_Name [] [Term] id: ARO:3000980 name: TEM-117 namespace: antibiotic_resistance def: "TEM-117 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-117" EXACT CARD_Short_Name [] [Term] id: ARO:3000981 name: TEM-118 namespace: antibiotic_resistance def: "TEM-118 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:12354869] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-118" EXACT CARD_Short_Name [] synonym: "TEM-HM" EXACT [] [Term] id: ARO:3000982 name: TEM-120 namespace: antibiotic_resistance def: "TEM-120 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca." [PMID:15047521] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-120" EXACT CARD_Short_Name [] [Term] id: ARO:3000983 name: TEM-121 namespace: antibiotic_resistance def: "TEM-121 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli and Klebsiella aerogenes." [PMID:15561821] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CMT-4" EXACT [] synonym: "TEM-121" EXACT CARD_Short_Name [] [Term] id: ARO:3000984 name: TEM-122 namespace: antibiotic_resistance def: "TEM-122 is an inhibitor-resistant beta-lactamase found in E. coli." [PMID:15105100] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-122" EXACT CARD_Short_Name [] [Term] id: ARO:3000985 name: TEM-123 namespace: antibiotic_resistance def: "TEM-123 is an extended-spectrum beta-lactamase found in Proteus mirabilis." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-123" EXACT CARD_Short_Name [] [Term] id: ARO:3000986 name: TEM-124 namespace: antibiotic_resistance def: "TEM-124 is an extended-spectrum beta-lactamase found in Morganella morganii." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-124" EXACT CARD_Short_Name [] [Term] id: ARO:3000987 name: TEM-125 namespace: antibiotic_resistance def: "TEM-125 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli." [PMID:16801418] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-125" EXACT CARD_Short_Name [] [Term] id: ARO:3000988 name: TEM-126 namespace: antibiotic_resistance def: "TEM-126 is an extended-spectrum beta-lactamase found in E. coli." [PMID:15282240] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-126" EXACT CARD_Short_Name [] [Term] id: ARO:3000989 name: TEM-127 namespace: antibiotic_resistance def: "TEM-127 is a broad-spectrum beta-lactamase found in E. coli." [PMID:15650379] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-127" EXACT CARD_Short_Name [] [Term] id: ARO:3000990 name: TEM-128 namespace: antibiotic_resistance def: "TEM-128 is a broad-spectrum beta-lactamase found in E. coli." [PMID:15650379] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-128" EXACT CARD_Short_Name [] [Term] id: ARO:3000993 name: TEM-129 namespace: antibiotic_resistance def: "TEM-129 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca." [PMID:15472005] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-129" EXACT CARD_Short_Name [] [Term] id: ARO:3000994 name: TEM-130 namespace: antibiotic_resistance def: "TEM-130 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-130" EXACT CARD_Short_Name [] [Term] id: ARO:3000995 name: TEM-131 namespace: antibiotic_resistance def: "TEM-131 is an extended-spectrum beta-lactamase found in Salmonella enterica." [PMID:15504851] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-131" EXACT CARD_Short_Name [] [Term] id: ARO:3000996 name: TEM-132 namespace: antibiotic_resistance def: "TEM-132 is an extended-spectrum beta-lactamase found in E. coli and Klebsiella pneumoniae." [PMID:15980402] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-132" EXACT CARD_Short_Name [] [Term] id: ARO:3000997 name: TEM-133 namespace: antibiotic_resistance def: "TEM-133 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:15855544] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-133" EXACT CARD_Short_Name [] [Term] id: ARO:3000998 name: TEM-134 namespace: antibiotic_resistance def: "TEM-134 is an extended-spectrum beta-lactamase found in Citrobacter koseri." [PMID:15793140] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-134" EXACT CARD_Short_Name [] [Term] id: ARO:3000999 name: TEM-135 namespace: antibiotic_resistance def: "TEM-135 is a broad-spectrum beta-lactamase found in Salmonella enterica." [PMID:15731203, PMID:31202926] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000054 ! penicillin synonym: "TEM-135" EXACT CARD_Short_Name [] [Term] id: ARO:3001000 name: TEM-136 namespace: antibiotic_resistance def: "TEM-136 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:16531430] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-136" EXACT CARD_Short_Name [] [Term] id: ARO:3001001 name: TEM-137 namespace: antibiotic_resistance def: "TEM-137 is an extended-spectrum beta-lactamase found in Shigella sonnei." [PMID:17561568] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-137" EXACT CARD_Short_Name [] [Term] id: ARO:3001002 name: TEM-138 namespace: antibiotic_resistance def: "TEM-138 is an extended-spectrum beta-lactamase found in Salmonella enterica." [PMID:16940125] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-138" EXACT CARD_Short_Name [] [Term] id: ARO:3001003 name: TEM-139 namespace: antibiotic_resistance def: "TEM-139 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:17382521] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-139" EXACT CARD_Short_Name [] [Term] id: ARO:3001004 name: TEM-141 namespace: antibiotic_resistance def: "TEM-141 is a broad-spectrum beta-lactamase found in Enterobacter cloacae." [PMID:17881870] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-141" EXACT CARD_Short_Name [] [Term] id: ARO:3001005 name: TEM-142 namespace: antibiotic_resistance def: "TEM-142 is an beta-lactamase found in E. coli." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-142" EXACT CARD_Short_Name [] [Term] id: ARO:3001006 name: TEM-143 namespace: antibiotic_resistance def: "TEM-143 is an extended-spectrum beta-lactamase found in E. coli." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-143" EXACT CARD_Short_Name [] [Term] id: ARO:3001007 name: TEM-144 namespace: antibiotic_resistance def: "TEM-144 is an extended-spectrum beta-lactamase found in Salmonella enterica." [PMID:16436745] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-144" EXACT CARD_Short_Name [] [Term] id: ARO:3001012 name: TEM-145 namespace: antibiotic_resistance def: "TEM-145 is an inhibitor-resistant beta-lactamase found in E. coli." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-145" EXACT CARD_Short_Name [] [Term] id: ARO:3001013 name: TEM-146 namespace: antibiotic_resistance def: "TEM-146 is a beta-lactamase found in E. coli." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-146" EXACT CARD_Short_Name [] [Term] id: ARO:3001014 name: TEM-147 namespace: antibiotic_resistance def: "TEM-147 is an extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-147" EXACT CARD_Short_Name [] [Term] id: ARO:3001015 name: TEM-148 namespace: antibiotic_resistance def: "TEM-148 is a TEM beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-148" EXACT CARD_Short_Name [] [Term] id: ARO:3001016 name: TEM-149 namespace: antibiotic_resistance def: "TEM-149 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes." [PMID:18160520] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-149" EXACT CARD_Short_Name [] [Term] id: ARO:3001017 name: TEM-150 namespace: antibiotic_resistance def: "TEM-150 is a beta-lactamase found in Enterobacter spp., E. coli, and Klebsiella pneumoniae." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-150" EXACT CARD_Short_Name [] [Term] id: ARO:3001018 name: TEM-151 namespace: antibiotic_resistance def: "TEM-151 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli." [PMID:17220412] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-151" EXACT CARD_Short_Name [] [Term] id: ARO:3001019 name: TEM-152 namespace: antibiotic_resistance def: "TEM-152 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli." [PMID:17220412] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-152" EXACT CARD_Short_Name [] [Term] id: ARO:3001020 name: TEM-154 namespace: antibiotic_resistance def: "TEM-154 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase." [PMID:17913717] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-154" EXACT CARD_Short_Name [] [Term] id: ARO:3001021 name: TEM-155 namespace: antibiotic_resistance def: "TEM-155 is an extended-spectrum beta-lactamase." [PMID:19075050] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-155" EXACT CARD_Short_Name [] [Term] id: ARO:3001022 name: TEM-156 namespace: antibiotic_resistance def: "TEM-156 is a TEM beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-156" EXACT CARD_Short_Name [] [Term] id: ARO:3001023 name: TEM-157 namespace: antibiotic_resistance def: "TEM-157 is an extended-spectrum beta-lactamase found in Enterobacter cloacae." [PMID:18653970] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-157" EXACT CARD_Short_Name [] [Term] id: ARO:3001024 name: TEM-158 namespace: antibiotic_resistance def: "TEM-158 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli." [PMID:17709463] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CMT-9" EXACT [] synonym: "TEM-158" EXACT CARD_Short_Name [] [Term] id: ARO:3001025 name: TEM-159 namespace: antibiotic_resistance def: "TEM-159 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis." [PMID:18292096] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-159" EXACT CARD_Short_Name [] [Term] id: ARO:3001026 name: TEM-160 namespace: antibiotic_resistance def: "TEM-160 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis." [PMID:18292096] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-160" EXACT CARD_Short_Name [] [Term] id: ARO:3001027 name: TEM-161 namespace: antibiotic_resistance def: "TEM-161 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001028 name: TEM-162 namespace: antibiotic_resistance def: "TEM-162 is a beta-lactamase found in Acinetobacter haemolyticus." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-162" EXACT CARD_Short_Name [] [Term] id: ARO:3001029 name: TEM-163 namespace: antibiotic_resistance def: "TEM-163 is an inhibitor resistant beta-lactamase found in E. coli." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-163" EXACT CARD_Short_Name [] [Term] id: ARO:3001030 name: TEM-164 namespace: antibiotic_resistance def: "TEM-164 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19728777] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-164" EXACT CARD_Short_Name [] [Term] id: ARO:3001031 name: TEM-165 namespace: antibiotic_resistance def: "TEM-165 is a beta-lactamase that has been found in clinical isolates." [PMID:21860889] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001032 name: TEM-166 namespace: antibiotic_resistance def: "TEM-166 is a beta-lactamase found in E. coli." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-166" EXACT CARD_Short_Name [] [Term] id: ARO:3001033 name: TEM-167 namespace: antibiotic_resistance def: "TEM-167 is an extended-spectrum beta-lactamase found in E. coli." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-167" EXACT CARD_Short_Name [] [Term] id: ARO:3001034 name: TEM-168 namespace: antibiotic_resistance def: "TEM-168 is an extended-spectrum beta-lactamase." [PMID:19687235] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-168" EXACT CARD_Short_Name [] [Term] id: ARO:3001035 name: TEM-169 namespace: antibiotic_resistance def: "TEM-169 is an extended spectrum beta-lactamase." [PMID:19785534] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-169" EXACT CARD_Short_Name [] [Term] id: ARO:3001036 name: TEM-170 namespace: antibiotic_resistance def: "TEM-170 is a beta-lactamase." [PMID:21903826] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001037 name: TEM-171 namespace: antibiotic_resistance def: "TEM-171 is a beta-lactamase." [PMID:21903826] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-171" EXACT CARD_Short_Name [] [Term] id: ARO:3001038 name: TEM-172 namespace: antibiotic_resistance def: "TEM-172 is a beta-lactamase." [PMID:21903826] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001039 name: TEM-173 namespace: antibiotic_resistance def: "TEM-173 is a beta-lactamase." [PMID:21903826] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001040 name: TEM-174 namespace: antibiotic_resistance def: "TEM-174 is a beta-lactamase." [PMID:21903826] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001041 name: TEM-176 namespace: antibiotic_resistance def: "TEM-176 is a beta-lactamase." [PMID:23643553] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-176" EXACT CARD_Short_Name [] [Term] id: ARO:3001042 name: TEM-177 namespace: antibiotic_resistance def: "TEM-177 is an extended-spectrum beta-lactamase." [PMID:23210906] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-177" EXACT CARD_Short_Name [] [Term] id: ARO:3001043 name: TEM-178 namespace: antibiotic_resistance def: "TEM-178 is an inhibitor-resistant, extended-spectrum beta-lactamase." [PMID:9371336] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-178" EXACT CARD_Short_Name [] [Term] id: ARO:3001044 name: TEM-181 namespace: antibiotic_resistance def: "TEM-181 is a beta-lactamase." [PMID:21947397] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-181" EXACT CARD_Short_Name [] [Term] id: ARO:3001045 name: TEM-183 namespace: antibiotic_resistance def: "TEM-183 is a broad-spectrum beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-183" EXACT CARD_Short_Name [] [Term] id: ARO:3001046 name: TEM-186 namespace: antibiotic_resistance def: "TEM-186 is a beta-lactamase." [PMID:22397509] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-186" EXACT CARD_Short_Name [] [Term] id: ARO:3001047 name: TEM-187 namespace: antibiotic_resistance def: "TEM-187 is an extended-spectrum beta-lactamase found in P. mirabilis." [PMID:23478954] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-187" EXACT CARD_Short_Name [] [Term] id: ARO:3001048 name: TEM-188 namespace: antibiotic_resistance def: "TEM-188 is an extended-spectrum beta-lactamase." [PMID:22871227] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-188" EXACT CARD_Short_Name [] [Term] id: ARO:3001049 name: TEM-189 namespace: antibiotic_resistance def: "TEM-189 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-189" EXACT CARD_Short_Name [] [Term] id: ARO:3001050 name: TEM-190 namespace: antibiotic_resistance def: "TEM-190 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-190" EXACT CARD_Short_Name [] [Term] id: ARO:3001051 name: TEM-191 namespace: antibiotic_resistance def: "TEM-191 is a beta-lactamase." [PMID:22718774] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-191" EXACT CARD_Short_Name [] [Term] id: ARO:3001052 name: TEM-192 namespace: antibiotic_resistance def: "TEM-192 is a beta-lactamase." [PMID:22718774] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-192" EXACT CARD_Short_Name [] [Term] id: ARO:3001053 name: TEM-193 namespace: antibiotic_resistance def: "TEM-193 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-193" EXACT CARD_Short_Name [] [Term] id: ARO:3001054 name: TEM-194 namespace: antibiotic_resistance def: "TEM-194 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-194" EXACT CARD_Short_Name [] [Term] id: ARO:3001055 name: TEM-195 namespace: antibiotic_resistance def: "TEM-195 is a beta-lactamase." [PMID:24499167] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-195" EXACT CARD_Short_Name [] [Term] id: ARO:3001056 name: TEM-197 namespace: antibiotic_resistance def: "TEM-197 is an extended-spectrum beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-197" EXACT CARD_Short_Name [] [Term] id: ARO:3001057 name: TEM-198 namespace: antibiotic_resistance def: "TEM-198 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-198" EXACT CARD_Short_Name [] [Term] id: ARO:3001058 name: TEM-199 namespace: antibiotic_resistance def: "TEM-199 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-199" EXACT CARD_Short_Name [] [Term] id: ARO:3001059 name: SHV-1 namespace: antibiotic_resistance def: "SHV-1 is a broad-spectrum beta-lactamase found in Klebsiella spp., as well as Acinetobacter spp., E. coli., Raoultella terrigena, and Yersinia pestis." [PMID:10582889, PMID:378931] is_a: ARO:3000015 ! SHV beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "PIT-2" EXACT [] synonym: "SHV-1" EXACT CARD_Short_Name [] [Term] id: ARO:3001060 name: SHV-2 namespace: antibiotic_resistance def: "SHV-2 is an extended-spectrum beta-lactamase found in E. coli., Klebsiella pneumoniae, and Shigella flexneri." [PMID:10582889, PMID:2033379] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-2" EXACT CARD_Short_Name [] [Term] id: ARO:3001061 name: SHV-2A namespace: antibiotic_resistance def: "SHV-2A is an extended-spectrum beta-lactamase found in Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica." [PMID:10223953] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-2A" EXACT CARD_Short_Name [] [Term] id: ARO:3001062 name: SHV-3 namespace: antibiotic_resistance def: "SHV-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:2694951, PMID:2033379] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-3" EXACT CARD_Short_Name [] [Term] id: ARO:3001063 name: SHV-4 namespace: antibiotic_resistance def: "SHV-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:2694955] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "CAZ-5" EXACT [] synonym: "SHV-4" EXACT CARD_Short_Name [] [Term] id: ARO:3001064 name: SHV-5 namespace: antibiotic_resistance def: "SHV-5 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii, Enterobacter cloacae, E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica." [PMID:2088203] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "CAZ-4" EXACT [] synonym: "SHV-5" EXACT CARD_Short_Name [] [Term] id: ARO:3001065 name: SHV-6 namespace: antibiotic_resistance def: "SHV-6 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:9228783] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-6" EXACT CARD_Short_Name [] [Term] id: ARO:3001066 name: SHV-7 namespace: antibiotic_resistance def: "SHV-7 is an extended-spectrum beta-lactamase found in E. coli." [PMID:7785992] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-7" EXACT CARD_Short_Name [] [Term] id: ARO:3001067 name: SHV-8 namespace: antibiotic_resistance def: "SHV-8 is an extended-spectrum beta-lactamase found in E. coli." [PMID:9056008] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-8" EXACT CARD_Short_Name [] [Term] id: ARO:3001068 name: SHV-9 namespace: antibiotic_resistance def: "SHV-9 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:9087500, PMID:8674992] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-5a" EXACT [] synonym: "SHV-9" EXACT CARD_Short_Name [] [Term] id: ARO:3001069 name: SHV-10 namespace: antibiotic_resistance def: "SHV-10 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:9087500] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001070 name: SHV-11 namespace: antibiotic_resistance def: "SHV-11 is a broad-spectrum beta-lactamase found in E. coli, Klebsiella pneumoniae, Proteus mirabilis, and Shigella dysenteriae." [PMID:9145849] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-1-2a" EXACT [] synonym: "SHV-11" EXACT CARD_Short_Name [] [Term] id: ARO:3001071 name: SHV-12 namespace: antibiotic_resistance def: "SHV-12 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii." [PMID:9145849] is_a: ARO:3000015 ! SHV beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "SHV-12" EXACT CARD_Short_Name [] synonym: "SHV-5-2a" EXACT [] [Term] id: ARO:3001072 name: SHV-13 namespace: antibiotic_resistance def: "SHV-13 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:10722518] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-13" EXACT CARD_Short_Name [] [Term] id: ARO:3001073 name: SHV-14 namespace: antibiotic_resistance def: "SHV-14 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:11120985] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-14" EXACT CARD_Short_Name [] [Term] id: ARO:3001074 name: SHV-15 namespace: antibiotic_resistance def: "SHV-15 is an extended-spectrum beta-lactamase found in E. coli." [PMID:10689171] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-15" EXACT CARD_Short_Name [] [Term] id: ARO:3001075 name: SHV-16 namespace: antibiotic_resistance def: "SHV-16 is an extended-spectrum beta-lactamase that has been found in clinical isolates. It differs from SHV-1 by a 163DRWET167 insertion." [PMID:11502518] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-16" EXACT CARD_Short_Name [] [Term] id: ARO:3001076 name: SHV-18 namespace: antibiotic_resistance def: "SHV-18 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii and Klebsiella pneumoniae." [PMID:10952583] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-18" EXACT CARD_Short_Name [] [Term] id: ARO:3001077 name: SHV-19 namespace: antibiotic_resistance def: "SHV-19 is a broad-spectrum beta-lactamase that has been found in clinical isolates." [PMID:11120950] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-19" EXACT CARD_Short_Name [] [Term] id: ARO:3001078 name: SHV-20 namespace: antibiotic_resistance def: "SHV-20 is a broad-spectrum beta-lactamase that has been found in clinical isolates." [PMID:11120950] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-20" EXACT CARD_Short_Name [] [Term] id: ARO:3001079 name: SHV-21 namespace: antibiotic_resistance def: "SHV-21 is a broad-spectrum beta-lactamase that has been found in clinical isolates." [PMID:11120950] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-21" EXACT CARD_Short_Name [] [Term] id: ARO:3001080 name: SHV-22 namespace: antibiotic_resistance def: "SHV-22 is a broad-spectrum beta-lactamase that has been found in clinical isolates." [PMID:11120950] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-22" EXACT CARD_Short_Name [] [Term] id: ARO:3001081 name: SHV-23 namespace: antibiotic_resistance def: "SHV-23 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:15081091] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-23" EXACT CARD_Short_Name [] [Term] id: ARO:3001082 name: SHV-24 namespace: antibiotic_resistance def: "SHV-24 is an extended-spectrum beta-lactamase found in E. coli." [PMID:10817740] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-24" EXACT CARD_Short_Name [] [Term] id: ARO:3001083 name: SHV-25 namespace: antibiotic_resistance def: "SHV-25 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:11502506] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-25" EXACT CARD_Short_Name [] [Term] id: ARO:3001084 name: SHV-26 namespace: antibiotic_resistance def: "SHV-26 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae." [PMID:11502506] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-26" EXACT CARD_Short_Name [] [Term] id: ARO:3001085 name: SHV-27 namespace: antibiotic_resistance def: "SHV-27 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:11266422] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-27" EXACT CARD_Short_Name [] [Term] id: ARO:3001086 name: SHV-28 namespace: antibiotic_resistance def: "SHV-28 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19172061] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-28" EXACT CARD_Short_Name [] [Term] id: ARO:3001087 name: SHV-29 namespace: antibiotic_resistance def: "SHV-29 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:11257029] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-29" EXACT CARD_Short_Name [] [Term] id: ARO:3001088 name: SHV-30 namespace: antibiotic_resistance def: "SHV-30 is an extended-spectrum beta-lactamase found in Enterobacter cloacae." [PMID:16251316] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-30" EXACT CARD_Short_Name [] [Term] id: ARO:3001089 name: SHV-31 namespace: antibiotic_resistance def: "SHV-31 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:17178800] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-31" EXACT CARD_Short_Name [] [Term] id: ARO:3001090 name: SHV-32 namespace: antibiotic_resistance def: "SHV-32 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:11557480] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-32" EXACT CARD_Short_Name [] [Term] id: ARO:3001091 name: SHV-33 namespace: antibiotic_resistance def: "SHV-33 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:11557480] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-33" EXACT CARD_Short_Name [] [Term] id: ARO:3001092 name: SHV-34 namespace: antibiotic_resistance def: "SHV-34 is an extended-spectrum beta-lactamase found in E. coli." [PMID:14613945] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-34" EXACT CARD_Short_Name [] [Term] id: ARO:3001093 name: SHV-35 namespace: antibiotic_resistance def: "SHV-35 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15047521] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-35" EXACT CARD_Short_Name [] [Term] id: ARO:3001094 name: SHV-36 namespace: antibiotic_resistance def: "SHV-36 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:17913717] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-36" EXACT CARD_Short_Name [] [Term] id: ARO:3001095 name: SHV-37 namespace: antibiotic_resistance def: "SHV-37 is a beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-37" EXACT CARD_Short_Name [] [Term] id: ARO:3001096 name: SHV-38 namespace: antibiotic_resistance def: "SHV-38 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:12543688] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-38" EXACT CARD_Short_Name [] [Term] id: ARO:3001097 name: SHV-39 namespace: antibiotic_resistance def: "SHV-39 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-39" EXACT CARD_Short_Name [] [Term] id: ARO:3001098 name: SHV-40 namespace: antibiotic_resistance def: "SHV-40 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:15047521] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-40" EXACT CARD_Short_Name [] [Term] id: ARO:3001099 name: SHV-41 namespace: antibiotic_resistance def: "SHV-41 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:15047521] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-41" EXACT CARD_Short_Name [] [Term] id: ARO:3001100 name: SHV-42 namespace: antibiotic_resistance def: "SHV-42 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:15047521] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-42" EXACT CARD_Short_Name [] [Term] id: ARO:3001101 name: SHV-43 namespace: antibiotic_resistance def: "SHV-43 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:12543694] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-43" EXACT CARD_Short_Name [] [Term] id: ARO:3001102 name: SHV-44 namespace: antibiotic_resistance def: "SHV-44 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:14576109] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-44" EXACT CARD_Short_Name [] [Term] id: ARO:3001103 name: SHV-45 namespace: antibiotic_resistance def: "SHV-45 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-45" EXACT CARD_Short_Name [] [Term] id: ARO:3001104 name: SHV-46 namespace: antibiotic_resistance def: "SHV-46 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca." [PMID:14638498] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-46" EXACT CARD_Short_Name [] [Term] id: ARO:3001105 name: SHV-48 namespace: antibiotic_resistance def: "SHV-48 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19075050] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-48" EXACT CARD_Short_Name [] [Term] id: ARO:3001106 name: SHV-49 namespace: antibiotic_resistance def: "SHV-49 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae." [PMID:15504885] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-49" EXACT CARD_Short_Name [] [Term] id: ARO:3001107 name: SHV-50 namespace: antibiotic_resistance def: "SHV-50 is a beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-50" EXACT CARD_Short_Name [] [Term] id: ARO:3001108 name: SHV-51 namespace: antibiotic_resistance def: "SHV-51 is a beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-51" EXACT CARD_Short_Name [] [Term] id: ARO:3001109 name: SHV-52 namespace: antibiotic_resistance def: "SHV-52 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-52" EXACT CARD_Short_Name [] [Term] id: ARO:3001110 name: SHV-53 namespace: antibiotic_resistance def: "SHV-53 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-53" EXACT CARD_Short_Name [] [Term] id: ARO:3001111 name: SHV-55 namespace: antibiotic_resistance def: "SHV-55 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:16938422] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-55" EXACT CARD_Short_Name [] [Term] id: ARO:3001112 name: SHV-56 namespace: antibiotic_resistance def: "SHV-56 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae." [PMID:18663019] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-56" EXACT CARD_Short_Name [] [Term] id: ARO:3001113 name: SHV-57 namespace: antibiotic_resistance def: "SHV-57 is an extended-spectrum beta-lactamase found in E. coli." [PMID:15673739] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-57" EXACT CARD_Short_Name [] [Term] id: ARO:3001114 name: SHV-59 namespace: antibiotic_resistance def: "SHV-59 is a beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-59" EXACT CARD_Short_Name [] [Term] id: ARO:3001115 name: SHV-60 namespace: antibiotic_resistance def: "SHV-60 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-60" EXACT CARD_Short_Name [] [Term] id: ARO:3001116 name: SHV-61 namespace: antibiotic_resistance def: "SHV-61 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-61" EXACT CARD_Short_Name [] [Term] id: ARO:3001117 name: SHV-62 namespace: antibiotic_resistance def: "SHV-62 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-62" EXACT CARD_Short_Name [] [Term] id: ARO:3001118 name: SHV-63 namespace: antibiotic_resistance def: "SHV-63 is a beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-63" EXACT CARD_Short_Name [] [Term] id: ARO:3001119 name: SHV-64 namespace: antibiotic_resistance def: "SHV-64 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:17288792] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-64" EXACT CARD_Short_Name [] [Term] id: ARO:3001120 name: SHV-65 namespace: antibiotic_resistance def: "SHV-65 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:17288792] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-65" EXACT CARD_Short_Name [] [Term] id: ARO:3001121 name: SHV-66 namespace: antibiotic_resistance def: "SHV-66 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:17288792] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-66" EXACT CARD_Short_Name [] [Term] id: ARO:3001122 name: SHV-67 namespace: antibiotic_resistance def: "SHV-67 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:17288792] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-67" EXACT CARD_Short_Name [] [Term] id: ARO:3001123 name: SHV-69 namespace: antibiotic_resistance def: "SHV-69 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:17288792] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-69" EXACT CARD_Short_Name [] [Term] id: ARO:3001124 name: SHV-70 namespace: antibiotic_resistance def: "SHV-70 is an extended-spectrum beta-lactamase found in Enterobacter cloacae." [PMID:16563703] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-70" EXACT CARD_Short_Name [] [Term] id: ARO:3001125 name: SHV-71 namespace: antibiotic_resistance def: "SHV-71 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and Shigella." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-71" EXACT CARD_Short_Name [] [Term] id: ARO:3001126 name: SHV-72 namespace: antibiotic_resistance def: "SHV-72 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae." [PMID:18316518] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-72" EXACT CARD_Short_Name [] [Term] id: ARO:3001127 name: SHV-73 namespace: antibiotic_resistance def: "SHV-73 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-73" EXACT CARD_Short_Name [] [Term] id: ARO:3001128 name: SHV-74 namespace: antibiotic_resistance def: "SHV-74 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-74" EXACT CARD_Short_Name [] [Term] id: ARO:3001129 name: SHV-75 namespace: antibiotic_resistance def: "SHV-75 is a broad-spectrum beta-lactamase that is found in clinical isolates." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-75" EXACT CARD_Short_Name [] [Term] id: ARO:3001130 name: SHV-76 namespace: antibiotic_resistance def: "SHV-76 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-76" EXACT CARD_Short_Name [] [Term] id: ARO:3001131 name: SHV-77 namespace: antibiotic_resistance def: "SHV-77 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and E. coli." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-77" EXACT CARD_Short_Name [] [Term] id: ARO:3001132 name: SHV-78 namespace: antibiotic_resistance def: "SHV-78 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-78" EXACT CARD_Short_Name [] [Term] id: ARO:3001133 name: SHV-79 namespace: antibiotic_resistance def: "SHV-79 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-79" EXACT CARD_Short_Name [] [Term] id: ARO:3001134 name: SHV-80 namespace: antibiotic_resistance def: "SHV-80 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-80" EXACT CARD_Short_Name [] [Term] id: ARO:3001135 name: SHV-81 namespace: antibiotic_resistance def: "SHV-81 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-81" EXACT CARD_Short_Name [] [Term] id: ARO:3001136 name: SHV-82 namespace: antibiotic_resistance def: "SHV-82 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-82" EXACT CARD_Short_Name [] [Term] id: ARO:3001137 name: SHV-83 namespace: antibiotic_resistance def: "SHV-83 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-83" EXACT CARD_Short_Name [] [Term] id: ARO:3001138 name: SHV-84 namespace: antibiotic_resistance def: "SHV-84 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates." [PMID:20211886] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-84" EXACT CARD_Short_Name [] [Term] id: ARO:3001139 name: SHV-85 namespace: antibiotic_resistance def: "SHV-85 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:18347108] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-85" EXACT CARD_Short_Name [] [Term] id: ARO:3001140 name: SHV-86 namespace: antibiotic_resistance def: "SHV-86 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:20566419] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-86" EXACT CARD_Short_Name [] [Term] id: ARO:3001141 name: SHV-89 namespace: antibiotic_resistance def: "SHV-89 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:18587684] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-89" EXACT CARD_Short_Name [] [Term] id: ARO:3001142 name: SHV-90 namespace: antibiotic_resistance def: "SHV-90 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:17913717] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001143 name: SHV-91 namespace: antibiotic_resistance def: "SHV-91 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:17913717] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001144 name: SHV-92 namespace: antibiotic_resistance def: "SHV-92 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:18029415] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-92" EXACT CARD_Short_Name [] [Term] id: ARO:3001145 name: SHV-93 namespace: antibiotic_resistance def: "SHV-93 is a beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-93" EXACT CARD_Short_Name [] [Term] id: ARO:3001146 name: SHV-94 namespace: antibiotic_resistance def: "SHV-94 is a beta-lactamase found in Klebsiella pneumoniae." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-94" EXACT CARD_Short_Name [] [Term] id: ARO:3001147 name: SHV-95 namespace: antibiotic_resistance def: "SHV-95 is a beta-lactamase found in Citrobacter freundii." [PMID:21383920] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-95" EXACT CARD_Short_Name [] [Term] id: ARO:3001148 name: SHV-96 namespace: antibiotic_resistance def: "SHV-96 is a beta-lactamase found in Acinetobacter baumannii." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-96" EXACT CARD_Short_Name [] [Term] id: ARO:3001149 name: SHV-97 namespace: antibiotic_resistance def: "SHV-97 is a beta-lactamase found in Enterococcus faecalis." [PMID:21940649] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-97" EXACT CARD_Short_Name [] [Term] id: ARO:3001150 name: SHV-101 namespace: antibiotic_resistance def: "SHV-101 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:17804424] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-101" EXACT CARD_Short_Name [] [Term] id: ARO:3001151 name: SHV-102 namespace: antibiotic_resistance def: "SHV-102 is an extended spectrum beta-lactamase found in E. coli." [PMID:18566158] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-102" EXACT CARD_Short_Name [] [Term] id: ARO:3001152 name: SHV-103 namespace: antibiotic_resistance def: "SHV-103 is a beta-lactamase that has been found in clinical isolates." [PMID:18620848] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-103" EXACT CARD_Short_Name [] [Term] id: ARO:3001153 name: SHV-104 namespace: antibiotic_resistance def: "SHV-104 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-104" EXACT CARD_Short_Name [] [Term] id: ARO:3001154 name: SHV-105 namespace: antibiotic_resistance def: "SHV-105 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:19075050] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-105" EXACT CARD_Short_Name [] [Term] id: ARO:3001155 name: SHV-106 namespace: antibiotic_resistance def: "SHV-106 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-106" EXACT CARD_Short_Name [] [Term] id: ARO:3001156 name: SHV-107 namespace: antibiotic_resistance def: "SHV-107 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-107" EXACT CARD_Short_Name [] [Term] id: ARO:3001157 name: SHV-108 namespace: antibiotic_resistance def: "SHV-108 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19272757, PMID:27598630] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-108" EXACT CARD_Short_Name [] [Term] id: ARO:3001158 name: SHV-109 namespace: antibiotic_resistance def: "SHV-109 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae." [PMID:18725449] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-109" EXACT CARD_Short_Name [] [Term] id: ARO:3001159 name: SHV-110 namespace: antibiotic_resistance def: "SHV-110 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19343954, PMID:27598630] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-110" EXACT CARD_Short_Name [] [Term] id: ARO:3001160 name: SHV-111 namespace: antibiotic_resistance def: "SHV-111 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19343954] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-111" EXACT CARD_Short_Name [] [Term] id: ARO:3001161 name: SHV-112 namespace: antibiotic_resistance def: "SHV-112 is a beta-lactamase that has been found in clinical isolates." [PMID:21123157] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-112" EXACT CARD_Short_Name [] [Term] id: ARO:3001162 name: SHV-113 namespace: antibiotic_resistance def: "SHV-113 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001163 name: SHV-114 namespace: antibiotic_resistance def: "SHV-114 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001164 name: SHV-115 namespace: antibiotic_resistance def: "SHV-115 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-115" EXACT CARD_Short_Name [] [Term] id: ARO:3001165 name: SHV-116 namespace: antibiotic_resistance def: "SHV-116 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-116" EXACT CARD_Short_Name [] [Term] id: ARO:3001166 name: SHV-117 namespace: antibiotic_resistance def: "SHV-117 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001167 name: SHV-120 namespace: antibiotic_resistance def: "SHV-120 is a beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-120" EXACT CARD_Short_Name [] [Term] id: ARO:3001168 name: SHV-121 namespace: antibiotic_resistance def: "SHV-121 is a beta-lactamase that has been found in clinical isolates. Identical to SHV-136." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-121" EXACT CARD_Short_Name [] synonym: "SHV-136" EXACT [] [Term] id: ARO:3001169 name: SHV-122 namespace: antibiotic_resistance def: "SHV-122 is a beta-lactamase that has been found in clinical isolates." [PMID:21359845] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-122" EXACT CARD_Short_Name [] [Term] id: ARO:3001170 name: SHV-123 namespace: antibiotic_resistance def: "SHV-123 is a beta-lactamase that has been found in clinical isolates." [PMID:21903826] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-123" EXACT CARD_Short_Name [] [Term] id: ARO:3001171 name: SHV-124 namespace: antibiotic_resistance def: "SHV-124 is a beta-lactamase that has been found in clinical isolates." [PMID:21903826] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-124" EXACT CARD_Short_Name [] [Term] id: ARO:3001172 name: SHV-125 namespace: antibiotic_resistance def: "SHV-125 is a beta-lactamase that has been found in clinical isolates." [PMID:21903826] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-125" EXACT CARD_Short_Name [] [Term] id: ARO:3001173 name: SHV-126 namespace: antibiotic_resistance def: "SHV-126 is a beta-lactamase that has been found in clinical isolates." [PMID:21903826] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-126" EXACT CARD_Short_Name [] [Term] id: ARO:3001174 name: SHV-127 namespace: antibiotic_resistance def: "SHV-127 is a beta-lactamase that has been found in clinical isolates." [PMID:21903826] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-127" EXACT CARD_Short_Name [] [Term] id: ARO:3001175 name: SHV-128 namespace: antibiotic_resistance def: "SHV-128 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-128" EXACT CARD_Short_Name [] [Term] id: ARO:3001176 name: SHV-129 namespace: antibiotic_resistance def: "SHV-129 is an extended-spectrum beta-lactamase that has been found in clinical isolates." [PMID:22322349] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-129" EXACT CARD_Short_Name [] [Term] id: ARO:3001177 name: SHV-133 namespace: antibiotic_resistance def: "SHV-133 is a beta-lactamase." [PMID:24475919] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-133" EXACT CARD_Short_Name [] [Term] id: ARO:3001178 name: SHV-134 namespace: antibiotic_resistance def: "SHV-134 is an extended-spectrum beta-lactamase." [PMID:22005997] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-134" EXACT CARD_Short_Name [] [Term] id: ARO:3001179 name: SHV-135 namespace: antibiotic_resistance def: "SHV-135 is a beta-lactamase." [PMID:23722448] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-135" EXACT CARD_Short_Name [] [Term] id: ARO:3001181 name: SHV-137 namespace: antibiotic_resistance def: "SHV-137 is a beta-lactamase." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-137" EXACT CARD_Short_Name [] [Term] id: ARO:3001182 name: SHV-140 namespace: antibiotic_resistance def: "SHV-140 is a broad-spectrum beta-lactamase." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-140" EXACT CARD_Short_Name [] [Term] id: ARO:3001183 name: SHV-141 namespace: antibiotic_resistance def: "SHV-141 is a broad-spectrum beta-lactamase." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-141" EXACT CARD_Short_Name [] [Term] id: ARO:3001184 name: SHV-142 namespace: antibiotic_resistance def: "SHV-142 is a beta-lactamase." [PMID:22537112] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-142" EXACT CARD_Short_Name [] [Term] id: ARO:3001185 name: SHV-145 namespace: antibiotic_resistance def: "SHV-145 is a beta-lactamase." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-145" EXACT CARD_Short_Name [] [Term] id: ARO:3001186 name: SHV-147 namespace: antibiotic_resistance def: "SHV-147 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-147" EXACT CARD_Short_Name [] [Term] id: ARO:3001187 name: SHV-148 namespace: antibiotic_resistance def: "SHV-148 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-148" EXACT CARD_Short_Name [] [Term] id: ARO:3001188 name: SHV-149 namespace: antibiotic_resistance def: "SHV-149 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-149" EXACT CARD_Short_Name [] [Term] id: ARO:3001189 name: SHV-150 namespace: antibiotic_resistance def: "SHV-150 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-150" EXACT CARD_Short_Name [] [Term] id: ARO:3001190 name: SHV-151 namespace: antibiotic_resistance def: "SHV-151 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-151" EXACT CARD_Short_Name [] [Term] id: ARO:3001191 name: SHV-152 namespace: antibiotic_resistance def: "SHV-152 is a beta-lactamase." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-152" EXACT CARD_Short_Name [] [Term] id: ARO:3001192 name: SHV-153 namespace: antibiotic_resistance def: "SHV-153 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-153" EXACT CARD_Short_Name [] [Term] id: ARO:3001193 name: SHV-154 namespace: antibiotic_resistance def: "SHV-154 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-154" EXACT CARD_Short_Name [] [Term] id: ARO:3001194 name: SHV-155 namespace: antibiotic_resistance def: "SHV-155 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-155" EXACT CARD_Short_Name [] [Term] id: ARO:3001195 name: SHV-156 namespace: antibiotic_resistance def: "SHV-156 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-156" EXACT CARD_Short_Name [] [Term] id: ARO:3001196 name: SHV-157 namespace: antibiotic_resistance def: "SHV-157 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-157" EXACT CARD_Short_Name [] [Term] id: ARO:3001197 name: SHV-158 namespace: antibiotic_resistance def: "SHV-158 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-158" EXACT CARD_Short_Name [] [Term] id: ARO:3001198 name: SHV-159 namespace: antibiotic_resistance def: "SHV-159 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-159" EXACT CARD_Short_Name [] [Term] id: ARO:3001199 name: SHV-160 namespace: antibiotic_resistance def: "SHV-160 is a beta-lactamase." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-160" EXACT CARD_Short_Name [] [Term] id: ARO:3001200 name: SHV-161 namespace: antibiotic_resistance def: "SHV-161 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-161" EXACT CARD_Short_Name [] [Term] id: ARO:3001201 name: SHV-162 namespace: antibiotic_resistance def: "SHV-162 is a beta-lactamase." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-162" EXACT CARD_Short_Name [] [Term] id: ARO:3001202 name: SHV-163 namespace: antibiotic_resistance def: "SHV-163 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-163" EXACT CARD_Short_Name [] [Term] id: ARO:3001203 name: SHV-165 namespace: antibiotic_resistance def: "SHV-165 is a beta-lactamase." [PMID:23587957] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-165" EXACT CARD_Short_Name [] [Term] id: ARO:3001204 name: SHV-167 namespace: antibiotic_resistance def: "SHV-167 is a beta-lactamase." [PMID:24336426] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-167" EXACT CARD_Short_Name [] [Term] id: ARO:3001205 name: BRP(MBL) namespace: antibiotic_resistance def: "A novel bleomycin resistance protein encoded by a metallo-beta-lactamase-associated ble gene. Expression of BRP(MBL) confers resistance to bleomycin and bleomycin-like antibiotics in Enterobacteriaceae and Acinetobacter, where it is co-expressed with an MBL and controlled by the same promoter region." [PMID:18791008, PMID:22290943] is_a: ARO:3004256 ! Bleomycin resistant protein relationship: confers_resistance_to_antibiotic ARO:3000690 ! bleomycinic acid relationship: confers_resistance_to_antibiotic ARO:3000691 ! bleomycin A2 relationship: confers_resistance_to_antibiotic ARO:3000692 ! bleomycin B2 relationship: participates_in ARO:3001206 ! antibiotic inactivation by sequestration synonym: "BRP" EXACT [] synonym: "BRP(MBL)" EXACT CARD_Short_Name [] synonym: "ble" EXACT [] synonym: "blmA" EXACT [] synonym: "blmS" EXACT [] [Term] id: ARO:3001206 name: antibiotic inactivation by sequestration namespace: antibiotic_resistance def: "Inactivation of an antibiotic by formation of a complex, preventing interaction of the antibiotic with its target." [PMID:18791008] is_a: ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3001207 name: gene involved in antibiotic sequestration namespace: antibiotic_resistance def: "A gene whose product inactivates an antibiotic by formation of a complex, preventing interaction of the antibiotic with its target." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:0001004 ! antibiotic inactivation [Term] id: ARO:3001208 name: methicillin resistant PBP2 namespace: antibiotic_resistance def: "In methicillin sensitive S. aureus (MSSA), beta-lactams bind to native penicillin-binding proteins (PBPs) and disrupt synthesis of the cell membrane's peptidoglycan layer. In methicillin resistant S. aureus (MRSA), foreign PBP2a acquired by lateral gene transfer is able to perform peptidoglycan synthesis in the presence of beta-lactams." [PMID:22941897, PMID:15226303, PMID:21641281, PMID:2708325, PMID:12389036, PMID:6563036] is_a: ARO:3000381 ! antibiotic target replacement protein is_a: ARO:3003040 ! beta-lactam resistant penicillin-binding proteins relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: part_of ARO:3000268 ! mec operon [Term] id: ARO:3001209 name: mecC namespace: antibiotic_resistance def: "A foreign PBP2a acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams." [PMID:21641281, PMID:23274660, PMID:22941897, PMID:28069659] is_a: ARO:3001208 ! methicillin resistant PBP2 relationship: confers_resistance_to_antibiotic ARO:0000015 ! methicillin synonym: "mecALGA251" EXACT [] synonym: "mecC" EXACT CARD_Short_Name [] [Term] id: ARO:3001214 name: mdtM namespace: antibiotic_resistance def: "Multidrug resistance protein MdtM." [PMID:23221628] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000047 ! puromycin relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "ECK4328" EXACT [] synonym: "JW4300" EXACT [] synonym: "mdtM" EXACT CARD_Short_Name [] synonym: "yjiO" EXACT [] [Term] id: ARO:3001216 name: mdtH namespace: antibiotic_resistance def: "Multidrug resistance protein MdtH." [PMID:19678712, PMID:15686558] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "mdtH" EXACT CARD_Short_Name [] [Term] id: ARO:3001218 name: trimethoprim resistant dihydrofolate reductase dfr namespace: antibiotic_resistance def: "Alternative dihydropteroate synthase dfr present on plasmids produces alternate proteins that are less sensitive to trimethoprim from inhibiting its role in folate synthesis, thus conferring trimethoprim resistance." [PMID:20169085] is_a: ARO:3003425 ! antibiotic resistant dihydrofolate reductase relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_drug_class ARO:3000171 ! diaminopyrimidine antibiotic relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase [Term] id: ARO:3001219 name: elfamycin antibiotic namespace: antibiotic_resistance def: "Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP." [PMID:12370016, PMID:16876786] is_a: ARO:1000003 ! antibiotic molecule synonym: "elfamycin" EXACT [] [Term] id: ARO:3001220 name: factumycin namespace: antibiotic_resistance def: "Factumycin is a kirromycin-like antibiotic produced by Kitasatospora setae and Streptomyces strains. Its biosynthetic cluster has been characterized which has interesting acetyl transferase domains in trans, or outside of the polyketide synthase domains. Factumycin has specific, rather than broad spectrum, antibacterial properties, especially targeting various Acinetobacter baumanii strains." [PMID:7166535] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:135410114 [Term] id: ARO:3001221 name: josamycin namespace: antibiotic_resistance def: "A macrolide antibiotic from Streptomyces narbonensis subsp. josamyceticus. The drug has antimicrobial activity against a wide spectrum of pathogens." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5284579 [Term] id: ARO:3001222 name: chalcomycin namespace: antibiotic_resistance def: "Produced by Streptomyces bikiniensis." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:6436271 [Term] id: ARO:3001223 name: midecamycin namespace: antibiotic_resistance def: "Produced by Streptomyces mycarofaciens." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5282169 [Term] id: ARO:3001224 name: mycinamicin namespace: antibiotic_resistance def: "Produced by Micromonospora griseorubida." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:6447311 [Term] id: ARO:3001225 name: megalomycin namespace: antibiotic_resistance def: "Produced by Micromonospora megalomicia." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:474871 [Term] id: ARO:3001226 name: narbomycin namespace: antibiotic_resistance def: "Produced by Streptomyces narbonensis." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5282036 [Term] id: ARO:3001227 name: kitasamycin namespace: antibiotic_resistance def: "Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens." [PMID:1838760] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5282189 [Term] id: ARO:3001228 name: carbomycin namespace: antibiotic_resistance def: "Produced by Streptomyces halstedii and Streptomyces thermotolerans." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5287879 [Term] id: ARO:3001229 name: rosaramicin namespace: antibiotic_resistance def: "Produced by Micromonospora rosaria." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:6537204 [Term] id: ARO:3001230 name: niddamycin namespace: antibiotic_resistance def: "Produced by Streptomyces caelestis." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:6440864 [Term] id: ARO:3001231 name: celesticetin namespace: antibiotic_resistance def: "Produced by Streptomyces caelestis, which also produces the macrolide niddamycin." [] is_a: ARO:0000017 ! lincosamide antibiotic xref: pubchem.compound:220087 [Term] id: ARO:3001232 name: methymycin namespace: antibiotic_resistance def: "Produced by Streptomyces venezuelae ATCC 15439." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5282034 [Term] id: ARO:3001233 name: pikromycin namespace: antibiotic_resistance def: "Produced by Streptomyces venezuelae ATCC 15439." [] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5282037 [Term] id: ARO:3001234 name: kirromycin namespace: antibiotic_resistance def: "Kirromycin, also known as mocimycin, is the representative molecule of its own class of elfamycins which is composed of more than 10 analogs. Kirromycin binds to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted." [PMID:3904612, PMID:9043138, PMID:2499247, PMID:337296, PMID:3356609, PMID:4373734, PMID:7925958] is_a: ARO:3001310 ! kirromycin-like antibiotics synonym: "mocimycin" EXACT [] xref: pubchem.compound:135452521 [Term] id: ARO:3001235 name: aurodox namespace: antibiotic_resistance def: "Aurodox is an elongation factor Tu inhibiting antibiotic. It was first referred to as X-5108. It is produced by Streptomyces goldiniensis var. goldiniensis and is active primarily against gram-positive bacteria." [PMID:4781274] is_a: ARO:3001310 ! kirromycin-like antibiotics synonym: "antibiotic X-5108" EXACT [] synonym: "goldinodox" EXACT [] synonym: "goldinomycin" EXACT [] synonym: "mocimycin" EXACT [] xref: pubchem.compound:135509117 [Term] id: ARO:3001236 name: efrotomycin namespace: antibiotic_resistance def: "Efrotomycin is produced by Streptomyces lactamodurans NRRL 3802. This kirromycin-like antibiotic is used in animal agriculture, especially in the production of swine. Generally gram negative bacteria are susceptible to efrotomycin, while gram positive bacteria are resistant." [PMID:1590753, PMID:16677683, PMID:950325, PMID:8515234] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:135434844 [Term] id: ARO:3001237 name: GE2270A namespace: antibiotic_resistance def: "GE2270A is the model molecule of cyclic thiazolyl peptide elfamycins. GE2270A is produced by Planobispora rosea. Biosynthesis of the molecule has been shown to originate as a ribosomally synthesized peptide that undergoes significant post-translational modification. Clinical use of cyclic thiazolyl peptides is hindered by their low water solubility and bioavailability." [PMID:20522549, PMID:20111801, PMID:16734421, PMID:8899707, PMID:10625477] is_a: ARO:3001309 ! cyclic thiazolyl peptide elfamycin xref: pubchem.compound:16129640 [Term] id: ARO:3001242 name: enacyloxin IIa namespace: antibiotic_resistance def: "Enacyloxin IIa is structurally distinct but acts in a similar mechanism to kirromycin-like elfamycins. It prohibits the transfer of the amino acid at the A site to the elongating peptide chain. It is most likely that the mechanism of action is that EF-Tu*GDP is locked in the EF-Tu*GTP form, and EF-Tu*GDP*aa-tRNA is immobilized on the ribosome. It is an open question whether enacyloxin IIa actually belongs to the kirromycin-like group of elfamycins due to their high similarity." [PMID:8665868, PMID:12370016] is_a: ARO:3001219 ! elfamycin antibiotic xref: pubchem.compound:6444164 [Term] id: ARO:3001246 name: kirrothricin namespace: antibiotic_resistance def: "Kirrothricin is produced by Streptomyces cinnamoneus and is structurally related to kirromycin, aurodox, heneicomycin and shares a similar spectrum of antibacterial activity." [PMID:7142013] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:54679291 [Term] id: ARO:3001247 name: azimycin namespace: antibiotic_resistance def: "Azimycin is produced by Streptomyces diastatochromogenes ATCC 31013." [PMID:3904612] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:5743 [Term] id: ARO:3001248 name: dihydromocimycin namespace: antibiotic_resistance def: "Dihydromocimycin is produced by Streptomyces ramocissimus CBS190.69." [PMID:2272911, PMID:3781906] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:54679334 [Term] id: ARO:3001249 name: phenelfamycin A namespace: antibiotic_resistance def: "Phenelfamycin A was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin A has a monosaccaride moeity and is isomeric with phenelfamycin B. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile." [PMID:2921230, PMID:3192490, PMID:3192489] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:6443943 [Term] id: ARO:3001250 name: phenelfamycin B namespace: antibiotic_resistance def: "Phenelfamycin B was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin B has a monosaccaride moeity and is isomeric with phenelfamycin A. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile." [PMID:3192490, PMID:2921230, PMID:3192489] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:6443944 [Term] id: ARO:3001251 name: phenelfamycin C namespace: antibiotic_resistance def: "Phenelfamycin C was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin C has a disaccaride moeity and is isomeric with phenelfamycin D. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile." [PMID:3192489, PMID:2921230, PMID:3192490] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:6443945 [Term] id: ARO:3001252 name: phenelfamycin D namespace: antibiotic_resistance def: "Phenelfamycin D was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin D has a disaccaride moeity and is isomeric with phenelfamycin C. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile." [PMID:3192489, PMID:2921230, PMID:3192490] is_a: ARO:3001310 ! kirromycin-like antibiotics [Term] id: ARO:3001253 name: phenelfamycin E namespace: antibiotic_resistance def: "Phenelfamycin E was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin E has a trisaccaride moeity and is isomeric with phenelfamycin F. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins." [PMID:3192489, PMID:3192490, PMID:2921230] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:71433564 [Term] id: ARO:3001256 name: phenelfamycin F namespace: antibiotic_resistance def: "Phenelfamycin F was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin F has a trisaccaride moeity and is isomeric with phenelfamycin E. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins." [PMID:3192489, PMID:2921230, PMID:3192490] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:90478571 [Term] id: ARO:3001257 name: unphenelfamycin namespace: antibiotic_resistance def: "Unphenelfamycin was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Unphenelfamycin has a monosaccaride moeity and lacks the phenacetyl moeity present in the other phenelfamycins. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile." [PMID:3192490, PMID:2921230, PMID:3192489] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:6443942 [Term] id: ARO:3001258 name: L-681,217 namespace: antibiotic_resistance def: "L-681217 is a kirromycin-like antibiotic produced by Streptomyces cattleya. Its biosynthetic gene cluster is characterized." [PMID:3781906] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:6439903 [Term] id: ARO:3001259 name: GE37468 namespace: antibiotic_resistance def: "GE37468 is a thiazolyl peptide produced by Streptomyces ATCC 55365. GE37468 is produced by post-transcription modification of a ribosomally synthesized preprotein, of which the biosynthetic gene cluster has been elucidated." [PMID:21788474] is_a: ARO:3001309 ! cyclic thiazolyl peptide elfamycin xref: pubchem.compound:101808822 [Term] id: ARO:3001260 name: amythiamicin A namespace: antibiotic_resistance def: "Amythiamicin A is a cyclic thiazolyl peptide antibiotic with a structure similar to GE2270A. Amythiamicin B, C, and D also exist, but are not discussed further here. Amythiamicin A was shown to have the highest activity in cell free protein synthesis assays." [PMID:7706132] is_a: ARO:3001309 ! cyclic thiazolyl peptide elfamycin xref: pubchem.compound:198789 [Term] id: ARO:3001264 name: heneicomycin namespace: antibiotic_resistance def: "Heneicomycin is a kirromycin-like antibiotic, isolated from Streptomyces filipinensis. It is structurally related to kirromycin, aurodox and efrotomycin." [PMID:1917698, PMID:468738] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:135612719 [Term] id: ARO:3001265 name: Erm(30) namespace: antibiotic_resistance def: "Erm(30) confers a MLSb resistant phenotype. Along with erm(31), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae." [PMID:14674753, PMID:9770448] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:3001226 ! narbomycin relationship: confers_resistance_to_antibiotic ARO:3001232 ! methymycin relationship: confers_resistance_to_antibiotic ARO:3001233 ! pikromycin synonym: "Erm(30)" EXACT CARD_Short_Name [] synonym: "Erm30" EXACT [] [Term] id: ARO:3001294 name: verdamicin namespace: antibiotic_resistance def: "A gentamicin-group aminoglycoside isolated from Micromonospora." [] is_a: ARO:0000016 ! aminoglycoside antibiotic xref: pubchem.compound:512877 [Term] id: ARO:3001295 name: vertilimicin namespace: antibiotic_resistance def: "A semisynthetic genamicin-group aminoglycoside, derived from verdamicin." [PMID:19635958] is_a: ARO:0000016 ! aminoglycoside antibiotic xref: pubchem.compound:52948322 [Term] id: ARO:3001296 name: kasugamycin namespace: antibiotic_resistance def: "An unusual aminoglycoside because the cyclitol ring is not amino substituted; it was discovered as a fermentation product of Streptomyces kasugaensis." [] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "kasugamicin" EXACT [] xref: pubchem.compound:65174 [Term] id: ARO:3001298 name: non-erm 23S ribosomal RNA methyltransferase (G748) namespace: antibiotic_resistance def: "Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides." [] is_a: ARO:3004274 ! 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic [Term] id: ARO:3001299 name: tlrB conferring tylosin resistance namespace: antibiotic_resistance def: "TlrB is a methyltransferase found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). TlrB is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide." [PMID:10348045, PMID:10972803] is_a: ARO:3000492 ! gene involved in self-resistance to antibiotic is_a: ARO:3001298 ! non-erm 23S ribosomal RNA methyltransferase (G748) relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin synonym: "Sfra_tlrB_TYL" EXACT CARD_Short_Name [] [Term] id: ARO:3001300 name: myrA namespace: antibiotic_resistance def: "myrA is a methyltransferase found in Micromonospora griseorubida and confers resistance to mycinamicin and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. MyrA is found in the mycinamicin biosynthetic cluster and is one mechanism by which M. griseorubida protects itself from self-destruction when producing this macrolide." [PMID:8163173, PMID:12417742] is_a: ARO:3000492 ! gene involved in self-resistance to antibiotic is_a: ARO:3001298 ! non-erm 23S ribosomal RNA methyltransferase (G748) relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3001224 ! mycinamicin synonym: "myrA" EXACT CARD_Short_Name [] [Term] id: ARO:3001301 name: RlmA(II) namespace: antibiotic_resistance def: "RlmA(II) is a methyltransferase found in Streptococcus pneumoniae and confers resistance to tylosin and mycinamicin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA." [PMID:12514124, PMID:18406425] is_a: ARO:3000492 ! gene involved in self-resistance to antibiotic is_a: ARO:3001298 ! non-erm 23S ribosomal RNA methyltransferase (G748) relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3001224 ! mycinamicin synonym: "RlmA(II)" EXACT CARD_Short_Name [] [Term] id: ARO:3001302 name: chrB namespace: antibiotic_resistance def: "ChrB is a methyltransferase found in Streptomyces bikiniensis and confers resistance to chalcomycin, mycinamicin, and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). chrB is found in the chalcomycin biosynthetic cluster and is responsible for self-resistance in S. bikiniensis." [PMID:15561847] is_a: ARO:3000492 ! gene involved in self-resistance to antibiotic is_a: ARO:3001298 ! non-erm 23S ribosomal RNA methyltransferase (G748) relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3001222 ! chalcomycin relationship: confers_resistance_to_antibiotic ARO:3001224 ! mycinamicin synonym: "chrB" EXACT CARD_Short_Name [] [Term] id: ARO:3001303 name: ErmO-srmA namespace: antibiotic_resistance def: "ErmO (gene srmA) is a methyltransferase found in the spiramycin producer Streptomyces ambofaciens. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is responsible for self-resistance to spiramycin." [PMID:10517588, PMID:1761231] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3001228 ! carbomycin synonym: "ErmO-srmA" EXACT CARD_Short_Name [] synonym: "srmA" EXACT [] [Term] id: ARO:3001304 name: ErmS namespace: antibiotic_resistance def: "ErmS is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers two methyl groups. The gene is found within the tylosin biosynthetic cluster and is responsible for self-resistance." [PMID:2753855, PMID:7961463, PMID:3127381, PMID:7495815, PMID:7534372, PMID:3020383] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3001228 ! carbomycin relationship: confers_resistance_to_antibiotic ARO:3001230 ! niddamycin synonym: "ErmS" EXACT CARD_Short_Name [] synonym: "ermSF" EXACT [] synonym: "tlrA" EXACT [] [Term] id: ARO:3001305 name: ErmU namespace: antibiotic_resistance def: "ErmU is a methyltransferase found in the lincomycin producer Streptomyces lincolnensis. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the lincomycin biosynthetic cluster and is responsible for self-resistance." [PMID:1328813, PMID:8577249] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin synonym: "ErmU" EXACT CARD_Short_Name [] synonym: "lrmB" EXACT [] [Term] id: ARO:3001306 name: ErmW namespace: antibiotic_resistance def: "ErmW is a methyltransferase found in the mycinamicin producer Micromonospora griseorubida. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the mycinamicin biosynthetic cluster and is responsible for self-resistance." [PMID:8163173, PMID:12583909] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3001221 ! josamycin synonym: "ErmW" EXACT CARD_Short_Name [] synonym: "myrB" EXACT [] [Term] id: ARO:3001307 name: vgbA namespace: antibiotic_resistance def: "vgbA inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond using an elimination mechanism, thus conferring resistance to these compounds." [PMID:17563376, PMID:11467949, PMID:15734650] is_a: ARO:3000376 ! streptogramin vgb lyase relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 synonym: "vgbA" EXACT CARD_Short_Name [] synonym: "vgh" EXACT [] xref: PDB:2Z2P [Term] id: ARO:3001308 name: vgbB namespace: antibiotic_resistance def: "VgbB inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond through an elimination mechanism, thus conferring resistance." [PMID:18341294] is_a: ARO:3000376 ! streptogramin vgb lyase relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 synonym: "vgbB" EXACT CARD_Short_Name [] [Term] id: ARO:3001309 name: cyclic thiazolyl peptide elfamycin namespace: antibiotic_resistance def: "Cyclic thiazolyl peptide elfamycins inhibit protein synthesis by preventing the formation of the EF-Tu*GTP-aa-tRNA ternary complex, a mechanism similar to that of pulvomycin. There are non-elfamycin cyclic thiazolyl peptide antibiotics which inhibit protein synthesis by by targeting the 50S ribosomal subunit and are not discussed here further." [PMID:12370016] is_a: ARO:3001219 ! elfamycin antibiotic [Term] id: ARO:3001310 name: kirromycin-like antibiotics namespace: antibiotic_resistance def: "Kirromycin-like antibiotics bind to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted." [] is_a: ARO:3001219 ! elfamycin antibiotic [Term] id: ARO:3001312 name: elfamycin resistant EF-Tu namespace: antibiotic_resistance def: "Sequence variants of elongation factor Tu that confer resistance to elfamycin antibiotics." [PMID:7925958, PMID:8899707, PMID:7525272, PMID:12370016, PMID:10610785, PMID:7957075] is_a: ARO:3003356 ! Antibiotic resistant EF-Tu relationship: confers_resistance_to_drug_class ARO:3001219 ! elfamycin antibiotic relationship: derives_from ARO:3000731 ! elongation factor Tu [Term] id: ARO:3001313 name: facT namespace: antibiotic_resistance def: "Efflux protein facT confers resistance to factumycin. The gene has been heterologously expressed in S. coelicolor and its function confirmed. It is possible that this gene can export other kirromycin-like elfamycins, but this has not been tested." [DOI:10.1039/C2MD20038D] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3001220 ! factumycin synonym: "facT" EXACT CARD_Short_Name [] [Term] id: ARO:3001314 name: retapamulin namespace: antibiotic_resistance def: "Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections." [PMID:17065625, PMID:16801451, PMID:16940066, PMID:17360517] is_a: ARO:3000670 ! pleuromutilin antibiotic xref: pubchem.compound:6918462 [Term] id: ARO:3001315 name: valnemulin namespace: antibiotic_resistance def: "Two semi-synthetic pleuromutilin derivatives, tiamulin and valnemulin, have been developed as antibiotics for veterinary use." [PMID:11555289, PMID:22070694] is_a: ARO:3000670 ! pleuromutilin antibiotic xref: pubchem.compound:9850878 [Term] id: ARO:3001316 name: azamulin namespace: antibiotic_resistance def: "Azamulin is a semi-synthetic pleuromutilin derivative that failed Stage 1 clinical trials due to poor bioavailability." [] is_a: ARO:3000670 ! pleuromutilin antibiotic xref: pubchem.compound:16072188 [Term] id: ARO:3001317 name: pleuromutilin namespace: antibiotic_resistance def: "Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound." [PMID:23589420] is_a: ARO:3000670 ! pleuromutilin antibiotic xref: pubchem.compound:31326 [Term] id: ARO:3001318 name: macrocyclic antibiotic namespace: antibiotic_resistance def: "Narrow spectrum macrocyclic antibiotics, in the general sense, is a cyclic molecule containing more than 12 atoms in the macrocyclic lactone ring." [PMID:22142153, PMID:24864039] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3001319 name: fidaxomicin namespace: antibiotic_resistance def: "A narrow spectrum antibiotic effective against Clostridioides difficile infection (CDI). It is active against gram positive and gram negative bacteria by inhibiting RNA polymerase's switch region leading to cell death." [PMID:21862392, PMID:22752863, PMID:21288078, PMID:24064437] is_a: ARO:3001318 ! macrocyclic antibiotic synonym: "OPT-80" EXACT [] xref: pubchem.compound:10034073 [Term] id: ARO:3001320 name: SB22484 namespace: antibiotic_resistance def: "SB22484 antibiotics are of the same chemical group as kirromycins. SB22484 antibiotics are produced by Streptomyces sp. NRRL 15496. There are two SB22484 isomers with the same UV absorption spectra, but differing molecular masses. These antibiotics are strongly active against Neisseria species, but also show activity against Streptococci, and Haemophilus influenzae." [PMID:2272911] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:53418992 [Term] id: ARO:3001321 name: UK-69,753 namespace: antibiotic_resistance def: "UK-69,753 is a glycosylated form of factumycin. The disaccharide moiety of UK-69,753 is virtually identical to that of efrotomycin, another member of this class of antibiotics. UK-69,753 has been shown to have strong in vitro and in vivo activity toward a swine pathogen, Treponema hyodysenteriae." [PMID:2584145] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:54681521 [Term] id: ARO:3001322 name: phenelfamycin G namespace: antibiotic_resistance def: "Phenelfamycin G is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes." [PMID:21285962] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:102306422 [Term] id: ARO:3001323 name: phenelfamycin H namespace: antibiotic_resistance def: "Phenelfamycin H is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes." [PMID:21285962] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:102306423 [Term] id: ARO:3001326 name: ganefromycin namespace: antibiotic_resistance def: "One of a small group of kirromycin-like elfamycins which lack the pyridone moiety. Ganefromycin is produced by Streptomyces lydicus spp. tanzanius, and was considered for use as a growth promoting antibiotic in agriculture." [PMID:8557574] is_a: ARO:3001310 ! kirromycin-like antibiotics xref: pubchem.compound:134158049 [Term] id: ARO:3001327 name: MdtK namespace: antibiotic_resistance def: "A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine." [PMID:16359323] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "MdtK" EXACT CARD_Short_Name [] synonym: "NorE" EXACT [] synonym: "YdhE" EXACT [] synonym: "norM" EXACT [] [Term] id: ARO:3001328 name: Escherichia coli mdfA namespace: antibiotic_resistance def: "Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter." [PMID:9811673, PMID:26238402] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3003823 ! benzalkonium chloride synonym: "Ecol_mdfA" EXACT CARD_Short_Name [] synonym: "cmlA" EXACT [] synonym: "cmr" EXACT [] [Term] id: ARO:3001329 name: mdtG namespace: antibiotic_resistance def: "The MdtG protein, also named YceE, appears to be a member of the major facilitator superfamily of transporters, and it has been reported, when overexpressed, to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon." [PMID:20008776] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "mdtG" EXACT CARD_Short_Name [] synonym: "yceE" EXACT [] [Term] id: ARO:3001331 name: SHV-54 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001332 name: SHV-58 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001333 name: SHV-68 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001334 name: SHV-87 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001335 name: SHV-88 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001336 name: SHV-98 namespace: antibiotic_resistance def: "SHV-98 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:21415202] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-98" EXACT CARD_Short_Name [] [Term] id: ARO:3001337 name: SHV-99 namespace: antibiotic_resistance def: "SHV-99 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:27598630, PMID:21415202] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-99" EXACT CARD_Short_Name [] [Term] id: ARO:3001338 name: SHV-100 namespace: antibiotic_resistance def: "SHV-100 is a beta-lactamase found in Klebsiella pneumoniae. It differs from SHV-1 by a 35SESQLSGRVGMIE36 insertion." [PMID:21415202] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-100" EXACT CARD_Short_Name [] [Term] id: ARO:3001339 name: SHV-118 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001340 name: SHV-119 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-119" EXACT CARD_Short_Name [] [Term] id: ARO:3001341 name: SHV-132 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-132" EXACT CARD_Short_Name [] [Term] id: ARO:3001342 name: SHV-138 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001343 name: SHV-139 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001344 name: SHV-143 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-143" EXACT CARD_Short_Name [] [Term] id: ARO:3001345 name: SHV-144 namespace: antibiotic_resistance def: "SHV-144 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:24270152] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-144" EXACT CARD_Short_Name [] [Term] id: ARO:3001346 name: SHV-146 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-146" EXACT CARD_Short_Name [] [Term] id: ARO:3001347 name: SHV-164 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-164" EXACT CARD_Short_Name [] [Term] id: ARO:3001348 name: SHV-166 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001349 name: SHV-174 namespace: antibiotic_resistance def: "SHV-174 is a beta-lactamase found in Enterobacteriaceae." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001350 name: SHV-180 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-180" EXACT CARD_Short_Name [] [Term] id: ARO:3001351 name: SHV-183 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-183" EXACT CARD_Short_Name [] [Term] id: ARO:3001352 name: SHV-168 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [PMID:23587779] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-168" EXACT CARD_Short_Name [] [Term] id: ARO:3001353 name: SHV-169 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001354 name: SHV-170 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001355 name: SHV-171 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-171" EXACT CARD_Short_Name [] [Term] id: ARO:3001356 name: SHV-172 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-172" EXACT CARD_Short_Name [] [Term] id: ARO:3001357 name: SHV-173 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-173" EXACT CARD_Short_Name [] [Term] id: ARO:3001358 name: SHV-175 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001359 name: SHV-176 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [PMID:24403301] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001360 name: SHV-177 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001361 name: SHV-178 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-178" EXACT CARD_Short_Name [] [Term] id: ARO:3001362 name: SHV-179 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-179" EXACT CARD_Short_Name [] [Term] id: ARO:3001363 name: SHV-181 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001364 name: SHV-182 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-182" EXACT CARD_Short_Name [] [Term] id: ARO:3001365 name: SHV-184 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase [Term] id: ARO:3001366 name: TEM-100 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001367 name: TEM-119 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001368 name: TEM-140 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001369 name: TEM-153 namespace: antibiotic_resistance def: "TEM-153 is a beta-lactamase found in Enterobacteriaceae." [PMID:23579192] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-153" EXACT CARD_Short_Name [] [Term] id: ARO:3001370 name: TEM-175 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001371 name: TEM-179 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001372 name: TEM-180 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001373 name: TEM-182 namespace: antibiotic_resistance def: "TEM-182 is a beta-lactamase found in clinical isolates of H. parainfluenzae." [PMID:23335113] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-182" EXACT CARD_Short_Name [] [Term] id: ARO:3001374 name: TEM-185 namespace: antibiotic_resistance def: "TEM-185 is a beta-lactamase found in E. coli." [PMID:22491692] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-185" EXACT CARD_Short_Name [] [Term] id: ARO:3001375 name: TEM-184 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-184" EXACT CARD_Short_Name [] [Term] id: ARO:3001376 name: TEM-196 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-196" EXACT CARD_Short_Name [] [Term] id: ARO:3001377 name: TEM-200 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001378 name: TEM-201 namespace: antibiotic_resistance def: "TEM-201 is a beta-lactamase found in Enterobacteriaceae." [PMID:24701189] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-201" EXACT CARD_Short_Name [] [Term] id: ARO:3001379 name: TEM-202 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001380 name: TEM-203 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001381 name: TEM-204 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001382 name: TEM-205 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-205" EXACT CARD_Short_Name [] [Term] id: ARO:3001383 name: TEM-206 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-206" EXACT CARD_Short_Name [] [Term] id: ARO:3001384 name: TEM-207 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-207" EXACT CARD_Short_Name [] [Term] id: ARO:3001385 name: TEM-208 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-208" EXACT CARD_Short_Name [] [Term] id: ARO:3001386 name: TEM-209 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-209" EXACT CARD_Short_Name [] [Term] id: ARO:3001387 name: TEM-210 namespace: antibiotic_resistance def: "TEM-210." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-210" EXACT CARD_Short_Name [] [Term] id: ARO:3001388 name: TEM-211 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-211" EXACT CARD_Short_Name [] [Term] id: ARO:3001389 name: TEM-212 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-212" EXACT CARD_Short_Name [] [Term] id: ARO:3001390 name: TEM-213 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-213" EXACT CARD_Short_Name [] [Term] id: ARO:3001391 name: TEM-214 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-214" EXACT CARD_Short_Name [] [Term] id: ARO:3001392 name: TEM-215 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-215" EXACT CARD_Short_Name [] [Term] id: ARO:3001393 name: TEM-216 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-216" EXACT CARD_Short_Name [] [Term] id: ARO:3001394 name: TEM-217 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released. Isolated from Enterobacter cloacae." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-217" EXACT CARD_Short_Name [] [Term] id: ARO:3001395 name: TEM-218 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3001396 name: OXA-1 namespace: antibiotic_resistance def: "OXA-1 is a beta-lactamase found in E. coli." [PMID:33416461, PMID:2823258] is_a: ARO:3007696 ! OXA-1-like beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "OXA-1" EXACT CARD_Short_Name [] synonym: "OXA-30" EXACT [] [Term] id: ARO:3001397 name: OXA-2 namespace: antibiotic_resistance def: "OXA-2 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:6335398, PMID:27499434] is_a: ARO:3007704 ! OXA-2-like beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "OXA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3001398 name: OXA-3 namespace: antibiotic_resistance def: "OXA-3 is a beta-lactamase found in P. aeruginosa." [PMID:7785990] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-3" EXACT CARD_Short_Name [] [Term] id: ARO:3001399 name: OXA-4 namespace: antibiotic_resistance def: "OXA-4 is a beta-lactamase found in Enterobacteriaceae and P. aeruginosa." [PMID:24426128] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-4" EXACT CARD_Short_Name [] [Term] id: ARO:3001400 name: OXA-5 namespace: antibiotic_resistance def: "OXA-5 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae." [PMID:3925874] is_a: ARO:3007723 ! OXA-5-like beta-lactamase synonym: "OXA-5" EXACT CARD_Short_Name [] [Term] id: ARO:3001401 name: OXA-6 namespace: antibiotic_resistance def: "OXA-5 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae." [PMID:3925874] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001402 name: OXA-7 namespace: antibiotic_resistance def: "OXA-7 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae." [PMID:3925874] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-7" EXACT CARD_Short_Name [] [Term] id: ARO:3001403 name: OXA-8 namespace: antibiotic_resistance def: "OXA-8 is an uncharacterized beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001404 name: OXA-9 namespace: antibiotic_resistance def: "OXA-9 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:9620445] is_a: ARO:3007735 ! OXA-9-like beta-lactamase synonym: "OXA-9" EXACT CARD_Short_Name [] [Term] id: ARO:3001405 name: OXA-10 namespace: antibiotic_resistance def: "OXA-10 is a beta-lactamase found in Acinetobacter baumannii and P. aeruginosa." [PMID:11017203, PMID:27499434] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-10" EXACT CARD_Short_Name [] synonym: "PSE-2" EXACT [] [Term] id: ARO:3001406 name: OXA-11 namespace: antibiotic_resistance def: "OXA-11 is a beta-lactamase found in P. aeruginosa." [PMID:8215276] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-11" EXACT CARD_Short_Name [] [Term] id: ARO:3001407 name: OXA-12 namespace: antibiotic_resistance def: "OXA-12 is a beta-lactamase found in Aeromonas jandaei." [PMID:9068648] is_a: ARO:3007699 ! OXA-12-like beta-lactamase synonym: "AsbB1" EXACT [] synonym: "OXA-12" EXACT CARD_Short_Name [] [Term] id: ARO:3001408 name: OXA-13 namespace: antibiotic_resistance def: "OXA-13 is a beta-lactamase found in P. aeruginosa." [PMID:9579076] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-13" EXACT CARD_Short_Name [] [Term] id: ARO:3001409 name: OXA-14 namespace: antibiotic_resistance def: "OXA-14 is a beta-lactamase found in P. aeruginosa." [PMID:7486940] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-14" EXACT CARD_Short_Name [] [Term] id: ARO:3001410 name: OXA-15 namespace: antibiotic_resistance def: "OXA-15 is a beta-lactamase found in P. aeruginosa." [PMID:9087490] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-15" EXACT CARD_Short_Name [] [Term] id: ARO:3001411 name: OXA-16 namespace: antibiotic_resistance def: "OXA-16 is a beta-lactamase found in P. aeruginosa." [PMID:9835501] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-16" EXACT CARD_Short_Name [] [Term] id: ARO:3001412 name: OXA-17 namespace: antibiotic_resistance def: "OXA-17 is a beta-lactamase found in P. aeruginosa and Klebsiella pneumoniae." [PMID:10348753] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-17" EXACT CARD_Short_Name [] [Term] id: ARO:3001413 name: OXA-18 namespace: antibiotic_resistance def: "OXA-18 is a beta-lactamase found in P. aeruginosa and Rickettsia." [PMID:9333046] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-18" EXACT CARD_Short_Name [] [Term] id: ARO:3001414 name: OXA-19 namespace: antibiotic_resistance def: "OXA-19 is a beta-lactamase found in P. aeruginosa." [PMID:9835500] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-19" EXACT CARD_Short_Name [] synonym: "intl1" EXACT [] [Term] id: ARO:3001415 name: OXA-20 namespace: antibiotic_resistance def: "OXA-20 is a beta-lactamase found in P. aeruginosa." [PMID:9687410] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-20" EXACT CARD_Short_Name [] [Term] id: ARO:3001416 name: OXA-21 namespace: antibiotic_resistance def: "OXA-21 is a beta-lactamase found in A. baumannii." [PMID:9420053] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-21" EXACT CARD_Short_Name [] [Term] id: ARO:3001417 name: OXA-22 namespace: antibiotic_resistance def: "OXA-22 is a beta-lactamase found in Ralstonia pickettii." [PMID:10898703] is_a: ARO:3007708 ! OXA-22-like beta-lactamase synonym: "OXA-22" EXACT CARD_Short_Name [] [Term] id: ARO:3001418 name: OXA-23 namespace: antibiotic_resistance def: "OXA-23 is a beta-lactamase found in A. baumannii." [PMID:10602749] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "ARI-1" EXACT [] synonym: "OXA-23" EXACT CARD_Short_Name [] [Term] id: ARO:3001419 name: OXA-24 namespace: antibiotic_resistance def: "OXA-24 is a beta-lactamase found in A. baumannii and P. aeruginosa." [PMID:18585868, PMID:10817708] is_a: ARO:3007711 ! OXA-24-like beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3003821 ! BAL30072 synonym: "OXA-24" EXACT CARD_Short_Name [] synonym: "OXA-40" EXACT [] [Term] id: ARO:3001420 name: OXA-25 namespace: antibiotic_resistance def: "OXA-25 is a beta-lactamase found in A. baumannii." [PMID:11158758] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-25" EXACT CARD_Short_Name [] [Term] id: ARO:3001421 name: OXA-26 namespace: antibiotic_resistance def: "OXA-26 is a beta-lactamase found in A. baumannii." [PMID:11158758] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-26" EXACT CARD_Short_Name [] [Term] id: ARO:3001422 name: OXA-27 namespace: antibiotic_resistance def: "OXA-27 is a beta-lactamase found in A. baumannii." [PMID:11158758] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-27" EXACT CARD_Short_Name [] [Term] id: ARO:3001423 name: OXA-28 namespace: antibiotic_resistance def: "OXA-28 is a beta-lactamase found in P. aeruginosa." [PMID:11158739] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-28" EXACT CARD_Short_Name [] [Term] id: ARO:3001424 name: OXA-29 namespace: antibiotic_resistance def: "OXA-29 is a beta-lactamase found in Legionella gormanii." [PMID:11709332] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-29" EXACT CARD_Short_Name [] [Term] id: ARO:3001425 name: OXA-31 namespace: antibiotic_resistance def: "OXA-31 is a beta-lactamase found in P. aeruginosa." [PMID:11353602] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-31" EXACT CARD_Short_Name [] [Term] id: ARO:3001426 name: OXA-32 namespace: antibiotic_resistance def: "OXA-32 is a beta-lactamase found in P. aeruginosa." [PMID:11796380] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-32" EXACT CARD_Short_Name [] [Term] id: ARO:3001427 name: OXA-33 namespace: antibiotic_resistance def: "OXA-33 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-33" EXACT CARD_Short_Name [] [Term] id: ARO:3001428 name: OXA-34 namespace: antibiotic_resistance def: "OXA-34 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-34" EXACT CARD_Short_Name [] [Term] id: ARO:3001429 name: OXA-35 namespace: antibiotic_resistance def: "OXA-35 is a beta-lactamase found in P. aeruginosa." [PMID:11679562] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-35" EXACT CARD_Short_Name [] [Term] id: ARO:3001430 name: OXA-36 namespace: antibiotic_resistance def: "OXA-36 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-36" EXACT CARD_Short_Name [] [Term] id: ARO:3001431 name: OXA-37 namespace: antibiotic_resistance def: "OXA-37 is a beta-lactamase found in A. baumannii." [PMID:12523622] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-37" EXACT CARD_Short_Name [] [Term] id: ARO:3001432 name: OXA-38 namespace: antibiotic_resistance def: "OXA-38 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001433 name: OXA-39 namespace: antibiotic_resistance def: "OXA-39 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001434 name: OXA-41 namespace: antibiotic_resistance def: "OXA-41 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001435 name: OXA-44 namespace: antibiotic_resistance def: "OXA-44 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001436 name: OXA-52 namespace: antibiotic_resistance def: "OXA-52 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001437 name: OXA-67 namespace: antibiotic_resistance def: "OXA-67 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-67" EXACT CARD_Short_Name [] [Term] id: ARO:3001438 name: OXA-100 namespace: antibiotic_resistance def: "OXA-100 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-100" EXACT CARD_Short_Name [] [Term] id: ARO:3001439 name: OXA-101 namespace: antibiotic_resistance def: "OXA-101 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-101" EXACT CARD_Short_Name [] [Term] id: ARO:3001440 name: OXA-115 namespace: antibiotic_resistance def: "OXA-115 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-115" EXACT CARD_Short_Name [] [Term] id: ARO:3001441 name: OXA-116 namespace: antibiotic_resistance def: "OXA-116 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-116" EXACT CARD_Short_Name [] [Term] id: ARO:3001442 name: OXA-117 namespace: antibiotic_resistance def: "OXA-117 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-117" EXACT CARD_Short_Name [] [Term] id: ARO:3001443 name: OXA-121 namespace: antibiotic_resistance def: "OXA-121 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-121" EXACT CARD_Short_Name [] [Term] id: ARO:3001444 name: OXA-122 namespace: antibiotic_resistance def: "OXA-122 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-122" EXACT CARD_Short_Name [] [Term] id: ARO:3001445 name: OXA-123 namespace: antibiotic_resistance def: "OXA-123 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-123" EXACT CARD_Short_Name [] [Term] id: ARO:3001446 name: OXA-124 namespace: antibiotic_resistance def: "OXA-124 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-124" EXACT CARD_Short_Name [] [Term] id: ARO:3001447 name: OXA-125 namespace: antibiotic_resistance def: "OXA-125 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-125" EXACT CARD_Short_Name [] [Term] id: ARO:3001448 name: OXA-126 namespace: antibiotic_resistance def: "OXA-126 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-126" EXACT CARD_Short_Name [] [Term] id: ARO:3001449 name: OXA-127 namespace: antibiotic_resistance def: "OXA-127 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-127" EXACT CARD_Short_Name [] [Term] id: ARO:3001451 name: OXA-139 namespace: antibiotic_resistance def: "OXA-139 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-139" EXACT CARD_Short_Name [] [Term] id: ARO:3001452 name: OXA-140 namespace: antibiotic_resistance def: "OXA-140 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-140" EXACT CARD_Short_Name [] [Term] id: ARO:3001453 name: OXA-148 namespace: antibiotic_resistance def: "OXA-148 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-148" EXACT CARD_Short_Name [] [Term] id: ARO:3001454 name: OXA-149 namespace: antibiotic_resistance def: "OXA-149 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-149" EXACT CARD_Short_Name [] [Term] id: ARO:3001455 name: OXA-150 namespace: antibiotic_resistance def: "OXA-150 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-150" EXACT CARD_Short_Name [] [Term] id: ARO:3001456 name: OXA-151 namespace: antibiotic_resistance def: "OXA-151 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-135" EXACT [] synonym: "OXA-151" EXACT CARD_Short_Name [] [Term] id: ARO:3001457 name: OXA-152 namespace: antibiotic_resistance def: "OXA-152 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-152" EXACT CARD_Short_Name [] [Term] id: ARO:3001458 name: OXA-153 namespace: antibiotic_resistance def: "OXA-153 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-153" EXACT CARD_Short_Name [] [Term] id: ARO:3001459 name: OXA-154 namespace: antibiotic_resistance def: "OXA-154 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-154" EXACT CARD_Short_Name [] [Term] id: ARO:3001460 name: OXA-155 namespace: antibiotic_resistance def: "OXA-155 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-155" EXACT CARD_Short_Name [] [Term] id: ARO:3001461 name: OXA-156 namespace: antibiotic_resistance def: "OXA-156 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-156" EXACT CARD_Short_Name [] [Term] id: ARO:3001462 name: OXA-157 namespace: antibiotic_resistance def: "OXA-157 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-157" EXACT CARD_Short_Name [] [Term] id: ARO:3001463 name: OXA-158 namespace: antibiotic_resistance def: "OXA-158 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-158" EXACT CARD_Short_Name [] [Term] id: ARO:3001464 name: OXA-159 namespace: antibiotic_resistance def: "OXA-159 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:26349828] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-159" EXACT CARD_Short_Name [] [Term] id: ARO:3001465 name: OXA-165 namespace: antibiotic_resistance def: "OXA-165 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-165" EXACT CARD_Short_Name [] [Term] id: ARO:3001466 name: OXA-166 namespace: antibiotic_resistance def: "OXA-166 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-166" EXACT CARD_Short_Name [] [Term] id: ARO:3001467 name: OXA-167 namespace: antibiotic_resistance def: "OXA-167 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-167" EXACT CARD_Short_Name [] [Term] id: ARO:3001468 name: OXA-168 namespace: antibiotic_resistance def: "OXA-168 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-168" EXACT CARD_Short_Name [] [Term] id: ARO:3001469 name: OXA-169 namespace: antibiotic_resistance def: "OXA-169 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-169" EXACT CARD_Short_Name [] [Term] id: ARO:3001470 name: OXA-170 namespace: antibiotic_resistance def: "OXA-170 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-170" EXACT CARD_Short_Name [] [Term] id: ARO:3001471 name: OXA-171 namespace: antibiotic_resistance def: "OXA-171 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-171" EXACT CARD_Short_Name [] [Term] id: ARO:3001472 name: OXA-178 namespace: antibiotic_resistance def: "OXA-178 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-178" EXACT CARD_Short_Name [] [Term] id: ARO:3001473 name: OXA-179 namespace: antibiotic_resistance def: "OXA-179 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-179" EXACT CARD_Short_Name [] [Term] id: ARO:3001474 name: OXA-180 namespace: antibiotic_resistance def: "OXA-180 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-180" EXACT CARD_Short_Name [] [Term] id: ARO:3001475 name: OXA-183 namespace: antibiotic_resistance def: "OXA-183 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-183" EXACT CARD_Short_Name [] [Term] id: ARO:3001476 name: OXA-184 namespace: antibiotic_resistance def: "OXA-184 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-184" EXACT CARD_Short_Name [] [Term] id: ARO:3001477 name: OXA-185 namespace: antibiotic_resistance def: "OXA-185 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-185" EXACT CARD_Short_Name [] [Term] id: ARO:3001478 name: OXA-193 namespace: antibiotic_resistance def: "OXA-193 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-193" EXACT CARD_Short_Name [] [Term] id: ARO:3001479 name: OXA-194 namespace: antibiotic_resistance def: "OXA-194 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-194" EXACT CARD_Short_Name [] [Term] id: ARO:3001480 name: OXA-195 namespace: antibiotic_resistance def: "OXA-195 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-195" EXACT CARD_Short_Name [] [Term] id: ARO:3001481 name: OXA-196 namespace: antibiotic_resistance def: "OXA-196 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-196" EXACT CARD_Short_Name [] [Term] id: ARO:3001482 name: OXA-197 namespace: antibiotic_resistance def: "OXA-197 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-197" EXACT CARD_Short_Name [] [Term] id: ARO:3001483 name: OXA-205 namespace: antibiotic_resistance def: "OXA-205 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007720 ! OXA-46-like beta-lactamase synonym: "OXA-205" EXACT CARD_Short_Name [] [Term] id: ARO:3001484 name: OXA-206 namespace: antibiotic_resistance def: "OXA-206 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-206" EXACT CARD_Short_Name [] [Term] id: ARO:3001485 name: OXA-207 namespace: antibiotic_resistance def: "OXA-207 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-207" EXACT CARD_Short_Name [] [Term] id: ARO:3001486 name: OXA-208 namespace: antibiotic_resistance def: "OXA-208 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-208" EXACT CARD_Short_Name [] [Term] id: ARO:3001487 name: OXA-210 namespace: antibiotic_resistance def: "OXA-210 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-210" EXACT CARD_Short_Name [] [Term] id: ARO:3001488 name: OXA-216 namespace: antibiotic_resistance def: "OXA-216 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-216" EXACT CARD_Short_Name [] [Term] id: ARO:3001489 name: OXA-217 namespace: antibiotic_resistance def: "OXA-217 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-217" EXACT CARD_Short_Name [] [Term] id: ARO:3001490 name: OXA-220 namespace: antibiotic_resistance def: "OXA-220 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001491 name: OXA-221 namespace: antibiotic_resistance def: "OXA-221 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001492 name: OXA-222 namespace: antibiotic_resistance def: "OXA-222 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001493 name: OXA-225 namespace: antibiotic_resistance def: "OXA-225 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-225" EXACT CARD_Short_Name [] [Term] id: ARO:3001494 name: OXA-227 namespace: antibiotic_resistance def: "OXA-227 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001495 name: OXA-233 namespace: antibiotic_resistance def: "OXA-233 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-233" EXACT CARD_Short_Name [] [Term] id: ARO:3001496 name: OXA-234 namespace: antibiotic_resistance def: "OXA-234 is a beta-lactamase found in Acinetobacter baumannii." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-234" EXACT CARD_Short_Name [] [Term] id: ARO:3001497 name: OXA-238 namespace: antibiotic_resistance def: "OXA-238 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001498 name: OXA-239 namespace: antibiotic_resistance def: "OXA-239 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-239" EXACT CARD_Short_Name [] [Term] id: ARO:3001499 name: OXA-240 namespace: antibiotic_resistance def: "OXA-240 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-240" EXACT CARD_Short_Name [] [Term] id: ARO:3001500 name: OXA-251 namespace: antibiotic_resistance def: "OXA-251 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-251" EXACT CARD_Short_Name [] [Term] id: ARO:3001501 name: OXA-252 namespace: antibiotic_resistance def: "OXA-252 is a beta-lactamase found in Shewanella spp." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-252" EXACT CARD_Short_Name [] [Term] id: ARO:3001502 name: OXA-256 namespace: antibiotic_resistance def: "OXA-256 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [PMID:23458448] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-256" EXACT CARD_Short_Name [] [Term] id: ARO:3001503 name: OXA-258 namespace: antibiotic_resistance def: "OXA-258 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-258" EXACT CARD_Short_Name [] [Term] id: ARO:3001504 name: OXA-309 namespace: antibiotic_resistance def: "OXA-309 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-309" EXACT CARD_Short_Name [] [Term] id: ARO:3001505 name: OXA-310 namespace: antibiotic_resistance def: "OXA-310 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001506 name: OXA-311 namespace: antibiotic_resistance def: "OXA-311 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001507 name: OXA-318 namespace: antibiotic_resistance def: "OXA-318 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001508 name: OXA-319 namespace: antibiotic_resistance def: "OXA-319 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001509 name: OXA-321 namespace: antibiotic_resistance def: "OXA-321 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001510 name: OXA-322 namespace: antibiotic_resistance def: "OXA-322 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-322" EXACT CARD_Short_Name [] [Term] id: ARO:3001511 name: OXA-323 namespace: antibiotic_resistance def: "OXA-323 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-323" EXACT CARD_Short_Name [] [Term] id: ARO:3001512 name: OXA-324 namespace: antibiotic_resistance def: "OXA-324 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-324" EXACT CARD_Short_Name [] [Term] id: ARO:3001513 name: OXA-325 namespace: antibiotic_resistance def: "OXA-325 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-325" EXACT CARD_Short_Name [] [Term] id: ARO:3001514 name: OXA-326 namespace: antibiotic_resistance def: "OXA-326 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-326" EXACT CARD_Short_Name [] [Term] id: ARO:3001515 name: OXA-327 namespace: antibiotic_resistance def: "OXA-327 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-327" EXACT CARD_Short_Name [] [Term] id: ARO:3001516 name: OXA-328 namespace: antibiotic_resistance def: "OXA-328 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-328" EXACT CARD_Short_Name [] [Term] id: ARO:3001517 name: OXA-329 namespace: antibiotic_resistance def: "OXA-329 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-329" EXACT CARD_Short_Name [] [Term] id: ARO:3001518 name: OXA-330 namespace: antibiotic_resistance def: "OXA-330 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-330" EXACT CARD_Short_Name [] [Term] id: ARO:3001519 name: OXA-331 namespace: antibiotic_resistance def: "OXA-331 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-331" EXACT CARD_Short_Name [] [Term] id: ARO:3001520 name: OXA-332 namespace: antibiotic_resistance def: "OXA-332 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-332" EXACT CARD_Short_Name [] [Term] id: ARO:3001521 name: OXA-333 namespace: antibiotic_resistance def: "OXA-333 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-333" EXACT CARD_Short_Name [] [Term] id: ARO:3001522 name: OXA-334 namespace: antibiotic_resistance def: "OXA-334 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-334" EXACT CARD_Short_Name [] [Term] id: ARO:3001523 name: OXA-335 namespace: antibiotic_resistance def: "OXA-335 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-335" EXACT CARD_Short_Name [] [Term] id: ARO:3001524 name: OXA-336 namespace: antibiotic_resistance def: "OXA-336 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-336" EXACT CARD_Short_Name [] [Term] id: ARO:3001525 name: OXA-337 namespace: antibiotic_resistance def: "OXA-337 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-337" EXACT CARD_Short_Name [] [Term] id: ARO:3001526 name: OXA-338 namespace: antibiotic_resistance def: "OXA-338 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-338" EXACT CARD_Short_Name [] [Term] id: ARO:3001527 name: OXA-339 namespace: antibiotic_resistance def: "OXA-339 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-339" EXACT CARD_Short_Name [] [Term] id: ARO:3001528 name: OXA-340 namespace: antibiotic_resistance def: "OXA-340 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-340" EXACT CARD_Short_Name [] [Term] id: ARO:3001529 name: OXA-341 namespace: antibiotic_resistance def: "OXA-341 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-341" EXACT CARD_Short_Name [] [Term] id: ARO:3001530 name: OXA-342 namespace: antibiotic_resistance def: "OXA-342 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-342" EXACT CARD_Short_Name [] [Term] id: ARO:3001531 name: OXA-343 namespace: antibiotic_resistance def: "OXA-343 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-343" EXACT CARD_Short_Name [] [Term] id: ARO:3001532 name: OXA-344 namespace: antibiotic_resistance def: "OXA-344 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-344" EXACT CARD_Short_Name [] [Term] id: ARO:3001533 name: OXA-345 namespace: antibiotic_resistance def: "OXA-345 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-345" EXACT CARD_Short_Name [] [Term] id: ARO:3001534 name: OXA-346 namespace: antibiotic_resistance def: "OXA-346 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-346" EXACT CARD_Short_Name [] [Term] id: ARO:3001535 name: OXA-348 namespace: antibiotic_resistance def: "OXA-348 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-348" EXACT CARD_Short_Name [] [Term] id: ARO:3001536 name: OXA-349 namespace: antibiotic_resistance def: "OXA-349 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-349" EXACT CARD_Short_Name [] [Term] id: ARO:3001537 name: OXA-350 namespace: antibiotic_resistance def: "OXA-350 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-350" EXACT CARD_Short_Name [] [Term] id: ARO:3001538 name: OXA-351 namespace: antibiotic_resistance def: "OXA-351 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-351" EXACT CARD_Short_Name [] [Term] id: ARO:3001539 name: OXA-352 namespace: antibiotic_resistance def: "OXA-352 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-352" EXACT CARD_Short_Name [] [Term] id: ARO:3001540 name: OXA-353 namespace: antibiotic_resistance def: "OXA-353 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-353" EXACT CARD_Short_Name [] [Term] id: ARO:3001541 name: OXA-354 namespace: antibiotic_resistance def: "OXA-354 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-354" EXACT CARD_Short_Name [] [Term] id: ARO:3001542 name: OXA-355 namespace: antibiotic_resistance def: "OXA-355 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-355" EXACT CARD_Short_Name [] [Term] id: ARO:3001543 name: OXA-356 namespace: antibiotic_resistance def: "OXA-356 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-356" EXACT CARD_Short_Name [] [Term] id: ARO:3001544 name: OXA-357 namespace: antibiotic_resistance def: "OXA-357 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-357" EXACT CARD_Short_Name [] [Term] id: ARO:3001545 name: OXA-358 namespace: antibiotic_resistance def: "OXA-358 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-358" EXACT CARD_Short_Name [] [Term] id: ARO:3001546 name: OXA-359 namespace: antibiotic_resistance def: "OXA-359 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-359" EXACT CARD_Short_Name [] [Term] id: ARO:3001547 name: OXA-360 namespace: antibiotic_resistance def: "OXA-360 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-360" EXACT CARD_Short_Name [] [Term] id: ARO:3001548 name: OXA-361 namespace: antibiotic_resistance def: "OXA-361 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-361" EXACT CARD_Short_Name [] [Term] id: ARO:3001549 name: OXA-362 namespace: antibiotic_resistance def: "OXA-362 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-362" EXACT CARD_Short_Name [] [Term] id: ARO:3001550 name: OXA-363 namespace: antibiotic_resistance def: "OXA-363 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-363" EXACT CARD_Short_Name [] [Term] id: ARO:3001551 name: OXA-364 namespace: antibiotic_resistance def: "OXA-364 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007716 ! OXA-364-like beta-lactamase synonym: "OXA-364" EXACT CARD_Short_Name [] [Term] id: ARO:3001552 name: OXA-365 namespace: antibiotic_resistance def: "OXA-365 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-365" EXACT CARD_Short_Name [] [Term] id: ARO:3001553 name: OXA-366 namespace: antibiotic_resistance def: "OXA-366 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-366" EXACT CARD_Short_Name [] [Term] id: ARO:3001554 name: OXA-367 namespace: antibiotic_resistance def: "OXA-367 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001555 name: OXA-368 namespace: antibiotic_resistance def: "OXA-368 is a beta-lactamase found in Aeromonas sobria. From the Lahey list of OXA beta-lactamases." [PMID:27499434] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-368" EXACT CARD_Short_Name [] [Term] id: ARO:3001557 name: OXA-371 namespace: antibiotic_resistance def: "OXA-371 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-371" EXACT CARD_Short_Name [] [Term] id: ARO:3001558 name: OXA-372 namespace: antibiotic_resistance def: "OXA-372 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007717 ! OXA-372-like beta-lactamase synonym: "OXA-372" EXACT CARD_Short_Name [] [Term] id: ARO:3001559 name: OXA-373 namespace: antibiotic_resistance def: "OXA-373 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-373" EXACT CARD_Short_Name [] [Term] id: ARO:3001560 name: OXA-374 namespace: antibiotic_resistance def: "OXA-374 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-374" EXACT CARD_Short_Name [] [Term] id: ARO:3001561 name: OXA-375 namespace: antibiotic_resistance def: "OXA-375 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-375" EXACT CARD_Short_Name [] [Term] id: ARO:3001562 name: OXA-376 namespace: antibiotic_resistance def: "OXA-376 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-376" EXACT CARD_Short_Name [] [Term] id: ARO:3001563 name: OXA-377 namespace: antibiotic_resistance def: "OXA-377 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-377" EXACT CARD_Short_Name [] [Term] id: ARO:3001564 name: OXA-378 namespace: antibiotic_resistance def: "OXA-378 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-378" EXACT CARD_Short_Name [] [Term] id: ARO:3001565 name: OXA-379 namespace: antibiotic_resistance def: "OXA-379 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-379" EXACT CARD_Short_Name [] [Term] id: ARO:3001566 name: OXA-380 namespace: antibiotic_resistance def: "OXA-380 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-380" EXACT CARD_Short_Name [] [Term] id: ARO:3001567 name: OXA-381 namespace: antibiotic_resistance def: "OXA-381 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-381" EXACT CARD_Short_Name [] [Term] id: ARO:3001568 name: OXA-382 namespace: antibiotic_resistance def: "OXA-382 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-382" EXACT CARD_Short_Name [] [Term] id: ARO:3001569 name: OXA-383 namespace: antibiotic_resistance def: "OXA-383 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-383" EXACT CARD_Short_Name [] [Term] id: ARO:3001570 name: OXA-384 namespace: antibiotic_resistance def: "OXA-384 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-384" EXACT CARD_Short_Name [] [Term] id: ARO:3001571 name: OXA-385 namespace: antibiotic_resistance def: "OXA-385 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-385" EXACT CARD_Short_Name [] [Term] id: ARO:3001572 name: OXA-386 namespace: antibiotic_resistance def: "OXA-386 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-386" EXACT CARD_Short_Name [] [Term] id: ARO:3001573 name: OXA-387 namespace: antibiotic_resistance def: "OXA-387 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-387" EXACT CARD_Short_Name [] [Term] id: ARO:3001574 name: OXA-388 namespace: antibiotic_resistance def: "OXA-388 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-388" EXACT CARD_Short_Name [] [Term] id: ARO:3001575 name: OXA-389 namespace: antibiotic_resistance def: "OXA-389 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-389" EXACT CARD_Short_Name [] [Term] id: ARO:3001576 name: OXA-390 namespace: antibiotic_resistance def: "OXA-390 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-390" EXACT CARD_Short_Name [] [Term] id: ARO:3001577 name: OXA-391 namespace: antibiotic_resistance def: "OXA-391 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-391" EXACT CARD_Short_Name [] [Term] id: ARO:3001578 name: OXA-392 namespace: antibiotic_resistance def: "OXA-392 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-392" EXACT CARD_Short_Name [] [Term] id: ARO:3001579 name: OXA-393 namespace: antibiotic_resistance def: "OXA-393 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001580 name: OXA-394 namespace: antibiotic_resistance def: "OXA-394 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001581 name: OXA-395 namespace: antibiotic_resistance def: "OXA-395 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-395" EXACT CARD_Short_Name [] [Term] id: ARO:3001582 name: OXA-396 namespace: antibiotic_resistance def: "OXA-396 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-396" EXACT CARD_Short_Name [] [Term] id: ARO:3001583 name: OXA-397 namespace: antibiotic_resistance def: "OXA-397 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007728 ! OXA-58-like beta-lactamase synonym: "OXA-397" EXACT CARD_Short_Name [] [Term] id: ARO:3001584 name: OXA-398 namespace: antibiotic_resistance def: "OXA-398 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-398" EXACT CARD_Short_Name [] [Term] id: ARO:3001585 name: OXA-399 namespace: antibiotic_resistance def: "OXA-399 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001586 name: OXA-400 namespace: antibiotic_resistance def: "OXA-400 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-400" EXACT CARD_Short_Name [] [Term] id: ARO:3001587 name: OXA-401 namespace: antibiotic_resistance def: "OXA-401 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-401" EXACT CARD_Short_Name [] [Term] id: ARO:3001588 name: OXA-402 namespace: antibiotic_resistance def: "OXA-402 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-402" EXACT CARD_Short_Name [] [Term] id: ARO:3001589 name: OXA-403 namespace: antibiotic_resistance def: "OXA-403 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-403" EXACT CARD_Short_Name [] [Term] id: ARO:3001595 name: OXA-404 namespace: antibiotic_resistance def: "OXA-404 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-404" EXACT CARD_Short_Name [] [Term] id: ARO:3001596 name: OXA-405 namespace: antibiotic_resistance def: "OXA-405 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-405" EXACT CARD_Short_Name [] [Term] id: ARO:3001597 name: OXA-406 namespace: antibiotic_resistance def: "OXA-406 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-406" EXACT CARD_Short_Name [] [Term] id: ARO:3001598 name: OXA-407 namespace: antibiotic_resistance def: "OXA-407 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-407" EXACT CARD_Short_Name [] [Term] id: ARO:3001599 name: OXA-408 namespace: antibiotic_resistance def: "OXA-408 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-408" EXACT CARD_Short_Name [] [Term] id: ARO:3001600 name: OXA-409 namespace: antibiotic_resistance def: "OXA-409 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-409" EXACT CARD_Short_Name [] [Term] id: ARO:3001601 name: OXA-410 namespace: antibiotic_resistance def: "OXA-410 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001602 name: OXA-411 namespace: antibiotic_resistance def: "OXA-411 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-411" EXACT CARD_Short_Name [] [Term] id: ARO:3001603 name: OXA-412 namespace: antibiotic_resistance def: "OXA-412 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-412" EXACT CARD_Short_Name [] [Term] id: ARO:3001604 name: OXA-413 namespace: antibiotic_resistance def: "OXA-413 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-413" EXACT CARD_Short_Name [] [Term] id: ARO:3001605 name: OXA-414 namespace: antibiotic_resistance def: "OXA-414 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-414" EXACT CARD_Short_Name [] [Term] id: ARO:3001606 name: OXA-415 namespace: antibiotic_resistance def: "OXA-415 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-415" EXACT CARD_Short_Name [] [Term] id: ARO:3001607 name: OXA-416 namespace: antibiotic_resistance def: "OXA-416 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-416" EXACT CARD_Short_Name [] [Term] id: ARO:3001608 name: OXA-417 namespace: antibiotic_resistance def: "OXA-417 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-417" EXACT CARD_Short_Name [] [Term] id: ARO:3001609 name: OXA-114a namespace: antibiotic_resistance def: "OXA-114a is a beta-lactamase found in Achromobacter xylosoxidans." [PMID:18362192] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114a" EXACT CARD_Short_Name [] [Term] id: ARO:3001610 name: OXA-243 namespace: antibiotic_resistance def: "OXA-243 is a beta-lactamase found in Achromobacter xylosoxidans." [PMID:22944724] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-243" EXACT CARD_Short_Name [] [Term] id: ARO:3001611 name: OXA-58 namespace: antibiotic_resistance def: "OXA-58 is a beta-lactamase found in A. baumannii." [PMID:15616297] is_a: ARO:3007728 ! OXA-58-like beta-lactamase synonym: "OXA-58" EXACT CARD_Short_Name [] [Term] id: ARO:3001612 name: OXA-51 namespace: antibiotic_resistance def: "OXA-51 is a beta-lactamase found in A. baumannii." [PMID:15649299] is_a: ARO:3007725 ! OXA-51-like beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3003821 ! BAL30072 synonym: "OXA-51" EXACT CARD_Short_Name [] [Term] id: ARO:3001613 name: OXA-64 namespace: antibiotic_resistance def: "OXA-64 is a beta-lactamase found in A. baumannii." [PMID:15760431] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-64" EXACT CARD_Short_Name [] [Term] id: ARO:3001614 name: OXA-65 namespace: antibiotic_resistance def: "OXA-65 is a beta-lactamase found in A. baumannii." [PMID:15760431] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-65" EXACT CARD_Short_Name [] [Term] id: ARO:3001615 name: OXA-66 namespace: antibiotic_resistance def: "OXA-66 is a beta-lactamase found in A. baumannii." [PMID:15760431] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-66" EXACT CARD_Short_Name [] [Term] id: ARO:3001616 name: OXA-68 namespace: antibiotic_resistance def: "OXA-68 is a beta-lactamase found in A. baumannii." [PMID:15760431] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-68" EXACT CARD_Short_Name [] [Term] id: ARO:3001617 name: OXA-69 namespace: antibiotic_resistance def: "OXA-69 is a beta-lactamase found in A. baumannii." [PMID:15760431] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-69" EXACT CARD_Short_Name [] [Term] id: ARO:3001618 name: OXA-70 namespace: antibiotic_resistance def: "OXA-70 is a beta-lactamase found in A. baumannii." [PMID:15760431] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-70" EXACT CARD_Short_Name [] [Term] id: ARO:3001619 name: OXA-71 namespace: antibiotic_resistance def: "OXA-71 is a beta-lactamase found in A. baumannii." [PMID:15760431] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-71" EXACT CARD_Short_Name [] [Term] id: ARO:3001620 name: OXA-75 namespace: antibiotic_resistance def: "OXA-75 is a beta-lactamase found in A. baumannii." [PMID:16189095] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-75" EXACT CARD_Short_Name [] [Term] id: ARO:3001621 name: OXA-76 namespace: antibiotic_resistance def: "OXA-76 is a beta-lactamase found in A. baumannii." [PMID:16189095] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-76" EXACT CARD_Short_Name [] [Term] id: ARO:3001622 name: OXA-77 namespace: antibiotic_resistance def: "OXA-77 is a beta-lactamase found in A. baumannii." [PMID:16189095] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-77" EXACT CARD_Short_Name [] [Term] id: ARO:3001623 name: OXA-83 namespace: antibiotic_resistance def: "OXA-83 is a beta-lactamase found in A. baumannii." [PMID:16630258] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-83" EXACT CARD_Short_Name [] [Term] id: ARO:3001624 name: OXA-84 namespace: antibiotic_resistance def: "OXA-84 is a beta-lactamase found in A. baumannii." [PMID:16630258] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-84" EXACT CARD_Short_Name [] [Term] id: ARO:3001625 name: OXA-89 namespace: antibiotic_resistance def: "OXA-89 is a beta-lactamase found in A. baumannii." [PMID:16844350] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-89" EXACT CARD_Short_Name [] [Term] id: ARO:3001626 name: OXA-88 namespace: antibiotic_resistance def: "OXA-88 is a beta-lactamase found in A. baumannii." [PMID:17284537] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-88" EXACT CARD_Short_Name [] [Term] id: ARO:3001627 name: OXA-91 namespace: antibiotic_resistance def: "OXA-91 is a beta-lactamase found in A. baumannii." [PMID:17284537] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-91" EXACT CARD_Short_Name [] [Term] id: ARO:3001628 name: OXA-93 namespace: antibiotic_resistance def: "OXA-93 is a beta-lactamase found in A. baumannii." [PMID:17284537] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-93" EXACT CARD_Short_Name [] [Term] id: ARO:3001629 name: OXA-94 namespace: antibiotic_resistance def: "OXA-94 is a beta-lactamase found in A. baumannii." [PMID:17284537] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-94" EXACT CARD_Short_Name [] [Term] id: ARO:3001630 name: OXA-95 namespace: antibiotic_resistance def: "OXA-95 is a beta-lactamase found in A. baumannii." [PMID:17284537] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-95" EXACT CARD_Short_Name [] [Term] id: ARO:3001631 name: OXA-96 namespace: antibiotic_resistance def: "OXA-96 is a beta-lactamase found in A. baumannii." [PMID:17284537] is_a: ARO:3007728 ! OXA-58-like beta-lactamase synonym: "OXA-96" EXACT CARD_Short_Name [] [Term] id: ARO:3001632 name: OXA-92 namespace: antibiotic_resistance def: "OXA-92 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-92" EXACT CARD_Short_Name [] [Term] id: ARO:3001633 name: OXA-79 namespace: antibiotic_resistance def: "OXA-79 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-79" EXACT CARD_Short_Name [] [Term] id: ARO:3001634 name: OXA-80 namespace: antibiotic_resistance def: "OXA-80 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-80" EXACT CARD_Short_Name [] [Term] id: ARO:3001635 name: OXA-82 namespace: antibiotic_resistance def: "OXA-82 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-82" EXACT CARD_Short_Name [] [Term] id: ARO:3001636 name: OXA-104 namespace: antibiotic_resistance def: "OXA-104 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-104" EXACT CARD_Short_Name [] [Term] id: ARO:3001637 name: OXA-106 namespace: antibiotic_resistance def: "OXA-106 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-106" EXACT CARD_Short_Name [] [Term] id: ARO:3001638 name: OXA-107 namespace: antibiotic_resistance def: "OXA-107 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-107" EXACT CARD_Short_Name [] [Term] id: ARO:3001639 name: OXA-108 namespace: antibiotic_resistance def: "OXA-108 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-108" EXACT CARD_Short_Name [] [Term] id: ARO:3001640 name: OXA-109 namespace: antibiotic_resistance def: "OXA-109 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-109" EXACT CARD_Short_Name [] [Term] id: ARO:3001641 name: OXA-110 namespace: antibiotic_resistance def: "OXA-110 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-110" EXACT CARD_Short_Name [] [Term] id: ARO:3001642 name: OXA-111 namespace: antibiotic_resistance def: "OXA-111 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-111" EXACT CARD_Short_Name [] [Term] id: ARO:3001643 name: OXA-112 namespace: antibiotic_resistance def: "OXA-112 is a beta-lactamase found in A. baumannii." [PMID:17391399] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-112" EXACT CARD_Short_Name [] [Term] id: ARO:3001644 name: OXA-113 namespace: antibiotic_resistance def: "OXA-113 is a beta-lactamase found in A. baumannii." [PMID:17881631] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-113" EXACT CARD_Short_Name [] [Term] id: ARO:3001645 name: OXA-78 namespace: antibiotic_resistance def: "OXA-78 is a beta-lactamase found in A. baumannii." [PMID:18190566] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-78" EXACT CARD_Short_Name [] [Term] id: ARO:3001646 name: OXA-98 namespace: antibiotic_resistance def: "OXA-98 is a beta-lactamase found in A. baumannii." [PMID:18190566] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-98" EXACT CARD_Short_Name [] [Term] id: ARO:3001647 name: OXA-97 namespace: antibiotic_resistance def: "OXA-97 is a beta-lactamase found in A. baumannii." [PMID:18299404] is_a: ARO:3007728 ! OXA-58-like beta-lactamase synonym: "OXA-97" EXACT CARD_Short_Name [] [Term] id: ARO:3001648 name: OXA-128 namespace: antibiotic_resistance def: "OXA-128 is a beta-lactamase found in A. baumannii." [PMID:19223304] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-128" EXACT CARD_Short_Name [] [Term] id: ARO:3001649 name: OXA-99 namespace: antibiotic_resistance def: "OXA-99 is a beta-lactamase found in A. baumannii." [PMID:19394202] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-99" EXACT CARD_Short_Name [] [Term] id: ARO:3001650 name: OXA-90 namespace: antibiotic_resistance def: "OXA-90 is a beta-lactamase found in A. baumannii." [PMID:19567349] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-90" EXACT CARD_Short_Name [] [Term] id: ARO:3001651 name: OXA-130 namespace: antibiotic_resistance def: "OXA-130 is a beta-lactamase found in A. baumannii." [PMID:19567349] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-130" EXACT CARD_Short_Name [] [Term] id: ARO:3001652 name: OXA-131 namespace: antibiotic_resistance def: "OXA-131 is a beta-lactamase found in A. baumannii." [PMID:19567349] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-131" EXACT CARD_Short_Name [] [Term] id: ARO:3001653 name: OXA-132 namespace: antibiotic_resistance def: "OXA-132 is a beta-lactamase found in A. baumannii." [PMID:19567349] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-132" EXACT CARD_Short_Name [] [Term] id: ARO:3001654 name: OXA-143 namespace: antibiotic_resistance def: "OXA-143 is a beta-lactamase found in A. baumannii." [PMID:19770279] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-143" EXACT CARD_Short_Name [] [Term] id: ARO:3001655 name: OXA-138 namespace: antibiotic_resistance def: "OXA-138 is a beta-lactamase found in A. baumannii." [PMID:20713680] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-138" EXACT CARD_Short_Name [] [Term] id: ARO:3001656 name: OXA-172 namespace: antibiotic_resistance def: "OXA-172 is a beta-lactamase found in A. baumannii." [PMID:20713680] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-172" EXACT CARD_Short_Name [] [Term] id: ARO:3001657 name: OXA-173 namespace: antibiotic_resistance def: "OXA-173 is a beta-lactamase found in A. baumannii." [PMID:20713680] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-173" EXACT CARD_Short_Name [] [Term] id: ARO:3001658 name: OXA-174 namespace: antibiotic_resistance def: "OXA-174 is a beta-lactamase found in A. baumannii." [PMID:20713680] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-174" EXACT CARD_Short_Name [] [Term] id: ARO:3001659 name: OXA-175 namespace: antibiotic_resistance def: "OXA-175 is a beta-lactamase found in A. baumannii." [PMID:20713680] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-175" EXACT CARD_Short_Name [] [Term] id: ARO:3001660 name: OXA-176 namespace: antibiotic_resistance def: "OXA-176 is a beta-lactamase found in A. baumannii." [PMID:20713680] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-176" EXACT CARD_Short_Name [] [Term] id: ARO:3001661 name: OXA-177 namespace: antibiotic_resistance def: "OXA-177 is a beta-lactamase found in A. baumannii." [PMID:20713680] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-177" EXACT CARD_Short_Name [] [Term] id: ARO:3001662 name: OXA-164 namespace: antibiotic_resistance def: "OXA-164 is a beta-lactamase found in A. baumannii." [PMID:20921306] is_a: ARO:3007728 ! OXA-58-like beta-lactamase synonym: "OXA-164" EXACT CARD_Short_Name [] [Term] id: ARO:3001663 name: OXA-160 namespace: antibiotic_resistance def: "OXA-160 is a beta-lactamase found in A. baumannii." [PMID:21041501] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-160" EXACT CARD_Short_Name [] [Term] id: ARO:3001664 name: OXA-203 namespace: antibiotic_resistance def: "OXA-203 is a beta-lactamase found in A. baumannii." [PMID:21289143] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-203" EXACT CARD_Short_Name [] [Term] id: ARO:3001665 name: OXA-200 namespace: antibiotic_resistance def: "OXA-200 is a beta-lactamase found in A. baumannii." [PMID:22422849] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-200" EXACT CARD_Short_Name [] [Term] id: ARO:3001666 name: OXA-201 namespace: antibiotic_resistance def: "OXA-201 is a beta-lactamase found in A. baumannii." [PMID:22422849] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-201" EXACT CARD_Short_Name [] [Term] id: ARO:3001667 name: OXA-202 namespace: antibiotic_resistance def: "OXA-202 is a beta-lactamase found in A. baumannii." [PMID:22422849] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-202" EXACT CARD_Short_Name [] [Term] id: ARO:3001668 name: OXA-219 namespace: antibiotic_resistance def: "OXA-219 is a beta-lactamase found in A. baumannii." [PMID:22422849] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-219" EXACT CARD_Short_Name [] [Term] id: ARO:3001669 name: OXA-223 namespace: antibiotic_resistance def: "OXA-223 is a beta-lactamase found in A. baumannii." [PMID:22422849] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-223" EXACT CARD_Short_Name [] [Term] id: ARO:3001670 name: OXA-231 namespace: antibiotic_resistance def: "OXA-231 is a beta-lactamase found in A. baumannii." [PMID:22736746] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-231" EXACT CARD_Short_Name [] [Term] id: ARO:3001671 name: OXA-49 namespace: antibiotic_resistance def: "OXA-49 is a beta-lactamase found in A. baumannii." [PMID:22842601] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-49" EXACT CARD_Short_Name [] [Term] id: ARO:3001672 name: OXA-120 namespace: antibiotic_resistance def: "OXA-120 is a beta-lactamase found in A. baumannii." [PMID:22972816] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-120" EXACT CARD_Short_Name [] [Term] id: ARO:3001673 name: OXA-248 namespace: antibiotic_resistance def: "OXA-248 is a beta-lactamase found in A. baumannii." [PMID:22972816] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-248" EXACT CARD_Short_Name [] [Term] id: ARO:3001674 name: OXA-249 namespace: antibiotic_resistance def: "OXA-249 is a beta-lactamase found in A. baumannii." [PMID:22972816] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-249" EXACT CARD_Short_Name [] [Term] id: ARO:3001675 name: OXA-250 namespace: antibiotic_resistance def: "OXA-250 is a beta-lactamase found in A. baumannii." [PMID:22972816] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-250" EXACT CARD_Short_Name [] [Term] id: ARO:3001676 name: OXA-235 namespace: antibiotic_resistance def: "OXA-235 is a beta-lactamase found in A. baumannii." [PMID:23439638] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-235" EXACT CARD_Short_Name [] [Term] id: ARO:3001677 name: OXA-236 namespace: antibiotic_resistance def: "OXA-236 is a beta-lactamase found in A. baumannii." [PMID:23439638] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-236" EXACT CARD_Short_Name [] [Term] id: ARO:3001678 name: OXA-237 namespace: antibiotic_resistance def: "OXA-237 is a beta-lactamase found in A. baumannii." [PMID:23439638] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-237" EXACT CARD_Short_Name [] [Term] id: ARO:3001679 name: OXA-241 namespace: antibiotic_resistance def: "OXA-241 is a beta-lactamase found in A. baumannii." [PMID:23439638] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-241" EXACT CARD_Short_Name [] [Term] id: ARO:3001680 name: OXA-242 namespace: antibiotic_resistance def: "OXA-242 is a beta-lactamase found in A. baumannii." [PMID:23439638] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-242" EXACT CARD_Short_Name [] [Term] id: ARO:3001681 name: OXA-278 namespace: antibiotic_resistance def: "OXA-278 is a beta-lactamase found in A. baumannii." [PMID:23554204] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-278" EXACT CARD_Short_Name [] [Term] id: ARO:3001682 name: OXA-254 namespace: antibiotic_resistance def: "OXA-254 is a beta-lactamase found in A. baumannii." [PMID:23719027] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-254" EXACT CARD_Short_Name [] [Term] id: ARO:3001683 name: OXA-312 namespace: antibiotic_resistance def: "OXA-312 is a beta-lactamase found in A. baumannii." [PMID:24247131] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-312" EXACT CARD_Short_Name [] [Term] id: ARO:3001684 name: OXA-313 namespace: antibiotic_resistance def: "OXA-313 is a beta-lactamase found in A. baumannii." [PMID:24247131] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-313" EXACT CARD_Short_Name [] [Term] id: ARO:3001685 name: OXA-314 namespace: antibiotic_resistance def: "OXA-314 is a beta-lactamase found in A. baumannii." [PMID:24247131] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-314" EXACT CARD_Short_Name [] [Term] id: ARO:3001686 name: OXA-315 namespace: antibiotic_resistance def: "OXA-315 is a beta-lactamase found in A. baumannii." [PMID:24247131] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-315" EXACT CARD_Short_Name [] [Term] id: ARO:3001687 name: OXA-316 namespace: antibiotic_resistance def: "OXA-316 is a beta-lactamase found in A. baumannii." [PMID:24247131] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-316" EXACT CARD_Short_Name [] [Term] id: ARO:3001688 name: OXA-317 namespace: antibiotic_resistance def: "OXA-317 is a beta-lactamase found in A. baumannii." [PMID:24247131] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-317" EXACT CARD_Short_Name [] [Term] id: ARO:3001689 name: OXA-253 namespace: antibiotic_resistance def: "OXA-253 is a beta-lactamase found in A. baumannii." [PMID:24566181] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-253" EXACT CARD_Short_Name [] [Term] id: ARO:3001690 name: OXA-255 namespace: antibiotic_resistance def: "OXA-255 is a beta-lactamase found in A. baumannii." [PMID:24566181] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-255" EXACT CARD_Short_Name [] [Term] id: ARO:3001691 name: OXA-228 namespace: antibiotic_resistance def: "OXA-228 is a beta-lactamase found in A. bereziniae." [PMID:22508298] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-228" EXACT CARD_Short_Name [] [Term] id: ARO:3001692 name: OXA-229 namespace: antibiotic_resistance def: "OXA-229 is a beta-lactamase found in A. bereziniae." [PMID:22508298] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-229" EXACT CARD_Short_Name [] [Term] id: ARO:3001693 name: OXA-230 namespace: antibiotic_resistance def: "OXA-230 is a beta-lactamase found in A. bereziniae." [PMID:22508298] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-230" EXACT CARD_Short_Name [] [Term] id: ARO:3001694 name: OXA-257 namespace: antibiotic_resistance def: "OXA-257 is a beta-lactamase found in A. bereziniae." [PMID:23934740] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-257" EXACT CARD_Short_Name [] [Term] id: ARO:3001695 name: OXA-134 namespace: antibiotic_resistance def: "OXA-134 is a beta-lactamase found in A. lwoffii." [PMID:20837764] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-134" EXACT CARD_Short_Name [] [Term] id: ARO:3001696 name: OXA-186 namespace: antibiotic_resistance def: "OXA-186 is a beta-lactamase found in A. lwoffii." [PMID:20837764] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001697 name: OXA-187 namespace: antibiotic_resistance def: "OXA-187 is a beta-lactamase found in A. lwoffii." [PMID:20837764] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001698 name: OXA-188 namespace: antibiotic_resistance def: "OXA-188 is a beta-lactamase found in A. lwoffii." [PMID:20837764] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001699 name: OXA-189 namespace: antibiotic_resistance def: "OXA-189 is a beta-lactamase found in A. lwoffii." [PMID:20837764] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001700 name: OXA-190 namespace: antibiotic_resistance def: "OXA-190 is a beta-lactamase found in A. lwoffii." [PMID:20837764] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001701 name: OXA-191 namespace: antibiotic_resistance def: "OXA-191 is a beta-lactamase found in A. lwoffii." [PMID:20837764] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001702 name: OXA-133 namespace: antibiotic_resistance def: "OXA-133 is a beta-lactamase found in A. radioresistens." [PMID:19015330] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-133" EXACT CARD_Short_Name [] [Term] id: ARO:3001703 name: OXA-86 namespace: antibiotic_resistance def: "OXA-86 is a beta-lactamase found in Acinetobacter spp." [PMID:16816400] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-86" EXACT CARD_Short_Name [] [Term] id: ARO:3001704 name: OXA-87 namespace: antibiotic_resistance def: "OXA-87 is a beta-lactamase found in Acinetobacter spp." [PMID:16816400] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-87" EXACT CARD_Short_Name [] [Term] id: ARO:3001705 name: OXA-72 namespace: antibiotic_resistance def: "OXA-72 is a beta-lactamase found in Acinetobacter spp." [PMID:17846127] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-72" EXACT CARD_Short_Name [] [Term] id: ARO:3001706 name: OXA-102 namespace: antibiotic_resistance def: "OXA-102 is a beta-lactamase found in Acinetobacter spp." [PMID:18195058] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3001707 name: OXA-103 namespace: antibiotic_resistance def: "OXA-103 is a beta-lactamase found in Acinetobacter spp." [PMID:18195058] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-103" EXACT CARD_Short_Name [] [Term] id: ARO:3001708 name: OXA-105 namespace: antibiotic_resistance def: "OXA-105 is a beta-lactamase found in Acinetobacter spp." [PMID:18195058] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-105" EXACT CARD_Short_Name [] [Term] id: ARO:3001709 name: OXA-182 namespace: antibiotic_resistance def: "OXA-182 is a beta-lactamase found in Acinetobacter spp." [PMID:20884158] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-182" EXACT CARD_Short_Name [] [Term] id: ARO:3001710 name: OXA-211 namespace: antibiotic_resistance def: "OXA-211 is a beta-lactamase found in Acinetobacter spp." [PMID:22128805] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-211" EXACT CARD_Short_Name [] [Term] id: ARO:3001711 name: OXA-212 namespace: antibiotic_resistance def: "OXA-212 is a beta-lactamase found in Acinetobacter spp." [PMID:22128805] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-212" EXACT CARD_Short_Name [] [Term] id: ARO:3001712 name: OXA-213 namespace: antibiotic_resistance def: "OXA-213 is a beta-lactamase found in Acinetobacter spp." [PMID:22128805] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-213" EXACT CARD_Short_Name [] [Term] id: ARO:3001713 name: OXA-214 namespace: antibiotic_resistance def: "OXA-214 is a beta-lactamase found in Acinetobacter spp." [PMID:22128805] is_a: ARO:3007707 ! OXA-214-like beta-lactamase synonym: "OXA-214" EXACT CARD_Short_Name [] [Term] id: ARO:3001714 name: OXA-215 namespace: antibiotic_resistance def: "OXA-215 is a beta-lactamase found in Acinetobacter spp." [PMID:22128805] is_a: ARO:3007707 ! OXA-214-like beta-lactamase synonym: "OXA-215" EXACT CARD_Short_Name [] [Term] id: ARO:3001715 name: OXA-259 namespace: antibiotic_resistance def: "OXA-259 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-259" EXACT CARD_Short_Name [] [Term] id: ARO:3001716 name: OXA-260 namespace: antibiotic_resistance def: "OXA-260 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-260" EXACT CARD_Short_Name [] [Term] id: ARO:3001717 name: OXA-261 namespace: antibiotic_resistance def: "OXA-261 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-261" EXACT CARD_Short_Name [] [Term] id: ARO:3001718 name: OXA-262 namespace: antibiotic_resistance def: "OXA-262 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-262" EXACT CARD_Short_Name [] [Term] id: ARO:3001719 name: OXA-263 namespace: antibiotic_resistance def: "OXA-263 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-263" EXACT CARD_Short_Name [] [Term] id: ARO:3001720 name: OXA-264 namespace: antibiotic_resistance def: "OXA-264 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007707 ! OXA-214-like beta-lactamase synonym: "OXA-264" EXACT CARD_Short_Name [] [Term] id: ARO:3001721 name: OXA-265 namespace: antibiotic_resistance def: "OXA-265 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007707 ! OXA-214-like beta-lactamase synonym: "OXA-265" EXACT CARD_Short_Name [] [Term] id: ARO:3001722 name: OXA-266 namespace: antibiotic_resistance def: "OXA-266 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007712 ! OXA-266-like beta-lactamase synonym: "OXA-266" EXACT CARD_Short_Name [] [Term] id: ARO:3001723 name: OXA-267 namespace: antibiotic_resistance def: "OXA-267 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-267" EXACT CARD_Short_Name [] [Term] id: ARO:3001724 name: OXA-268 namespace: antibiotic_resistance def: "OXA-268 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-268" EXACT CARD_Short_Name [] [Term] id: ARO:3001725 name: OXA-269 namespace: antibiotic_resistance def: "OXA-269 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-269" EXACT CARD_Short_Name [] [Term] id: ARO:3001726 name: OXA-270 namespace: antibiotic_resistance def: "OXA-270 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-270" EXACT CARD_Short_Name [] [Term] id: ARO:3001727 name: OXA-271 namespace: antibiotic_resistance def: "OXA-271 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-271" EXACT CARD_Short_Name [] [Term] id: ARO:3001728 name: OXA-272 namespace: antibiotic_resistance def: "OXA-272 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-272" EXACT CARD_Short_Name [] [Term] id: ARO:3001729 name: OXA-273 namespace: antibiotic_resistance def: "OXA-273 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-273" EXACT CARD_Short_Name [] [Term] id: ARO:3001730 name: OXA-274 namespace: antibiotic_resistance def: "OXA-274 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043, PMID:30247543] is_a: ARO:3007713 ! OXA-274-like beta-lactamase synonym: "OXA-274" EXACT CARD_Short_Name [] [Term] id: ARO:3001731 name: OXA-275 namespace: antibiotic_resistance def: "OXA-275 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007713 ! OXA-274-like beta-lactamase synonym: "OXA-275" EXACT CARD_Short_Name [] [Term] id: ARO:3001732 name: OXA-276 namespace: antibiotic_resistance def: "OXA-276 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-276" EXACT CARD_Short_Name [] [Term] id: ARO:3001733 name: OXA-277 namespace: antibiotic_resistance def: "OXA-277 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-277" EXACT CARD_Short_Name [] [Term] id: ARO:3001734 name: OXA-279 namespace: antibiotic_resistance def: "OXA-279 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-279" EXACT CARD_Short_Name [] [Term] id: ARO:3001735 name: OXA-280 namespace: antibiotic_resistance def: "OXA-280 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-280" EXACT CARD_Short_Name [] [Term] id: ARO:3001736 name: OXA-281 namespace: antibiotic_resistance def: "OXA-281 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-281" EXACT CARD_Short_Name [] [Term] id: ARO:3001737 name: OXA-282 namespace: antibiotic_resistance def: "OXA-282 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-282" EXACT CARD_Short_Name [] [Term] id: ARO:3001738 name: OXA-283 namespace: antibiotic_resistance def: "OXA-283 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-283" EXACT CARD_Short_Name [] [Term] id: ARO:3001739 name: OXA-284 namespace: antibiotic_resistance def: "OXA-284 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-284" EXACT CARD_Short_Name [] [Term] id: ARO:3001740 name: OXA-285 namespace: antibiotic_resistance def: "OXA-285 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-285" EXACT CARD_Short_Name [] [Term] id: ARO:3001741 name: OXA-286 namespace: antibiotic_resistance def: "OXA-286 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043, PMID:30247543] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-286" EXACT CARD_Short_Name [] [Term] id: ARO:3001742 name: OXA-287 namespace: antibiotic_resistance def: "OXA-287 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-287" EXACT CARD_Short_Name [] [Term] id: ARO:3001743 name: OXA-288 namespace: antibiotic_resistance def: "OXA-288 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-288" EXACT CARD_Short_Name [] [Term] id: ARO:3001744 name: OXA-289 namespace: antibiotic_resistance def: "OXA-289 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-289" EXACT CARD_Short_Name [] [Term] id: ARO:3001745 name: OXA-290 namespace: antibiotic_resistance def: "OXA-290 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-290" EXACT CARD_Short_Name [] [Term] id: ARO:3001746 name: OXA-291 namespace: antibiotic_resistance def: "OXA-291 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-291" EXACT CARD_Short_Name [] [Term] id: ARO:3001747 name: OXA-292 namespace: antibiotic_resistance def: "OXA-292 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-292" EXACT CARD_Short_Name [] [Term] id: ARO:3001748 name: OXA-293 namespace: antibiotic_resistance def: "OXA-293 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-293" EXACT CARD_Short_Name [] [Term] id: ARO:3001749 name: OXA-294 namespace: antibiotic_resistance def: "OXA-294 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007715 ! OXA-294-like beta-lactamase synonym: "OXA-294" EXACT CARD_Short_Name [] [Term] id: ARO:3001750 name: OXA-295 namespace: antibiotic_resistance def: "OXA-295 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007715 ! OXA-294-like beta-lactamase synonym: "OXA-295" EXACT CARD_Short_Name [] [Term] id: ARO:3001751 name: OXA-296 namespace: antibiotic_resistance def: "OXA-296 is a beta-lactamase found in Acinetobacter spp." [PMID:30247543, PMID:24277043] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-296" EXACT CARD_Short_Name [] [Term] id: ARO:3001752 name: OXA-297 namespace: antibiotic_resistance def: "OXA-297 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007715 ! OXA-294-like beta-lactamase synonym: "OXA-297" EXACT CARD_Short_Name [] [Term] id: ARO:3001753 name: OXA-298 namespace: antibiotic_resistance def: "OXA-298 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007715 ! OXA-294-like beta-lactamase synonym: "OXA-298" EXACT CARD_Short_Name [] [Term] id: ARO:3001754 name: OXA-299 namespace: antibiotic_resistance def: "OXA-299 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-299" EXACT CARD_Short_Name [] [Term] id: ARO:3001755 name: OXA-300 namespace: antibiotic_resistance def: "OXA-300 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-300" EXACT CARD_Short_Name [] [Term] id: ARO:3001756 name: OXA-301 namespace: antibiotic_resistance def: "OXA-301 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-301" EXACT CARD_Short_Name [] [Term] id: ARO:3001757 name: OXA-302 namespace: antibiotic_resistance def: "OXA-302 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-302" EXACT CARD_Short_Name [] [Term] id: ARO:3001758 name: OXA-303 namespace: antibiotic_resistance def: "OXA-303 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-303" EXACT CARD_Short_Name [] [Term] id: ARO:3001759 name: OXA-304 namespace: antibiotic_resistance def: "OXA-304 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-304" EXACT CARD_Short_Name [] [Term] id: ARO:3001760 name: OXA-305 namespace: antibiotic_resistance def: "OXA-305 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-305" EXACT CARD_Short_Name [] [Term] id: ARO:3001761 name: OXA-306 namespace: antibiotic_resistance def: "OXA-306 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-306" EXACT CARD_Short_Name [] [Term] id: ARO:3001762 name: OXA-307 namespace: antibiotic_resistance def: "OXA-307 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-307" EXACT CARD_Short_Name [] [Term] id: ARO:3001763 name: OXA-308 namespace: antibiotic_resistance def: "OXA-308 is a beta-lactamase found in Acinetobacter spp." [PMID:24277043] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-308" EXACT CARD_Short_Name [] [Term] id: ARO:3001764 name: OXA-63 namespace: antibiotic_resistance def: "OXA-63 is a beta-lactamase found in Brachyspira spp." [PMID:18212108] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-63" EXACT CARD_Short_Name [] [Term] id: ARO:3001765 name: OXA-136 namespace: antibiotic_resistance def: "OXA-136 is a beta-lactamase found in Brachyspira spp." [PMID:18719182] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-136" EXACT CARD_Short_Name [] [Term] id: ARO:3001766 name: OXA-192 namespace: antibiotic_resistance def: "OXA-192 is a beta-lactamase found in Brachyspira spp." [PMID:21812718] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-192" EXACT CARD_Short_Name [] [Term] id: ARO:3001767 name: OXA-137 namespace: antibiotic_resistance def: "OXA-137 is a beta-lactamase found in Brachyspira spp." [PMID:18719182] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-137" EXACT CARD_Short_Name [] [Term] id: ARO:3001768 name: OXA-118 namespace: antibiotic_resistance def: "OXA-118 is a beta-lactamase found in Burkholderia cepacia." [PMID:11972706] is_a: ARO:3007720 ! OXA-46-like beta-lactamase synonym: "OXA-118" EXACT CARD_Short_Name [] [Term] id: ARO:3001769 name: OXA-42 namespace: antibiotic_resistance def: "OXA-42 is a beta-lactamase found in Burkholderia pseudomallei." [PMID:12356787] is_a: ARO:3007718 ! OXA-42-like beta-lactamase synonym: "OXA-42" EXACT CARD_Short_Name [] [Term] id: ARO:3001770 name: OXA-43 namespace: antibiotic_resistance def: "OXA-43 is a beta-lactamase found in Burkholderia pseudomallei." [PMID:12356787] is_a: ARO:3007718 ! OXA-42-like beta-lactamase synonym: "OXA-43" EXACT CARD_Short_Name [] [Term] id: ARO:3001771 name: OXA-57 namespace: antibiotic_resistance def: "OXA-57 is a beta-lactamase found in Burkholderia pseudomallei." [PMID:15793160] is_a: ARO:3007718 ! OXA-42-like beta-lactamase synonym: "OXA-57" EXACT CARD_Short_Name [] [Term] id: ARO:3001772 name: OXA-59 namespace: antibiotic_resistance def: "OXA-59 is a beta-lactamase found in Burkholderia pseudomallei." [PMID:15793160] is_a: ARO:3007718 ! OXA-42-like beta-lactamase synonym: "OXA-59" EXACT CARD_Short_Name [] [Term] id: ARO:3001773 name: OXA-61 namespace: antibiotic_resistance def: "OXA-61 is a beta-lactamase found in Campylobacter jejuni." [PMID:15917560] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-61" EXACT CARD_Short_Name [] [Term] id: ARO:3001774 name: OXA-370 namespace: antibiotic_resistance def: "OXA-370 is a beta-lactamase found in Enterobacter hormaechei." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-370" EXACT CARD_Short_Name [] [Term] id: ARO:3001775 name: OXA-119 namespace: antibiotic_resistance def: "OXA-119 is a beta-lactamase found in Enterobacteriaceae." [PMID:19719593] is_a: ARO:3007720 ! OXA-46-like beta-lactamase synonym: "OXA-119" EXACT CARD_Short_Name [] [Term] id: ARO:3001776 name: OXA-162 namespace: antibiotic_resistance def: "OXA-162 is a beta-lactamase found in Enterobacteriaceae." [PMID:22290940] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-162" EXACT CARD_Short_Name [] [Term] id: ARO:3001777 name: OXA-347 namespace: antibiotic_resistance def: "OXA-347 is a beta-lactamase found in Enterobacteriaceae." [PMID:22845886] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-347" EXACT CARD_Short_Name [] [Term] id: ARO:3001778 name: OXA-232 namespace: antibiotic_resistance def: "OXA-232 is a beta-lactamase found in Enterobacteriaceae." [PMID:23305656] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-232" EXACT CARD_Short_Name [] [Term] id: ARO:3001779 name: OXA-146 namespace: antibiotic_resistance def: "OXA-146 is a beta-lactamase found in Enterobacteriaceae." [PMID:23877677] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-146" EXACT CARD_Short_Name [] [Term] id: ARO:3001780 name: OXA-85 namespace: antibiotic_resistance def: "OXA-85 is a beta-lactamase found in Fusobacterium nucleatum." [PMID:16870757] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-85" EXACT CARD_Short_Name [] [Term] id: ARO:3001781 name: OXA-47 namespace: antibiotic_resistance def: "OXA-47 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:14693513] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-47" EXACT CARD_Short_Name [] [Term] id: ARO:3001782 name: OXA-48 namespace: antibiotic_resistance def: "OXA-48 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:14693513] is_a: ARO:3007721 ! OXA-48-like beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3003831 ! temocillin synonym: "OXA-48" EXACT CARD_Short_Name [] [Term] id: ARO:3001783 name: OXA-163 namespace: antibiotic_resistance def: "OXA-163 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:21422200] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-163" EXACT CARD_Short_Name [] [Term] id: ARO:3001784 name: OXA-181 namespace: antibiotic_resistance def: "OXA-181 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:21768505] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-181" EXACT CARD_Short_Name [] [Term] id: ARO:3001785 name: OXA-73 namespace: antibiotic_resistance def: "OXA-73 is a beta-lactamase found in Klebsiella pneumonia." [PMID:22842601] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-73" EXACT CARD_Short_Name [] [Term] id: ARO:3001786 name: OXA-244 namespace: antibiotic_resistance def: "OXA-244 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:23034714] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-244" EXACT CARD_Short_Name [] [Term] id: ARO:3001787 name: OXA-245 namespace: antibiotic_resistance def: "OXA-245 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:23034714] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-245" EXACT CARD_Short_Name [] [Term] id: ARO:3001788 name: OXA-204 namespace: antibiotic_resistance def: "OXA-204 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:23114766] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-204" EXACT CARD_Short_Name [] [Term] id: ARO:3001791 name: OXA-247 namespace: antibiotic_resistance def: "OXA-247 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:23402333] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-247" EXACT CARD_Short_Name [] [Term] id: ARO:3001792 name: OXA-62 namespace: antibiotic_resistance def: "OXA-62 is a beta-lactamase found in Pandoraea pnomenusa." [PMID:16569848] is_a: ARO:3007731 ! OXA-62-like beta-lactamase synonym: "OXA-62" EXACT CARD_Short_Name [] [Term] id: ARO:3001793 name: OXA-320 namespace: antibiotic_resistance def: "OXA-320 is a beta-lactamase found in Proteus mirabilis." [PMID:24027220] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-320" EXACT CARD_Short_Name [] [Term] id: ARO:3001794 name: OXA-45 namespace: antibiotic_resistance def: "OXA-45 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:12936985] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-45" EXACT CARD_Short_Name [] [Term] id: ARO:3001795 name: OXA-56 namespace: antibiotic_resistance def: "OXA-56 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:15047554] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-56" EXACT CARD_Short_Name [] [Term] id: ARO:3001796 name: OXA-50 namespace: antibiotic_resistance def: "OXA-50 is a beta-lactamase found in Pseudomonas aeruginosa. It confers decreased susceptibility to ampicillin and ticarcillin and, interestingly, to moxalactam and meropenem in P. aeruginosa but not in E. coli. Also confers resistance to piperacillin-tazobactam and cephalotin." [PMID:15155197] is_a: ARO:3007724 ! OXA-50-like beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "OXA-50" EXACT CARD_Short_Name [] [Term] id: ARO:3001797 name: OXA-46 namespace: antibiotic_resistance def: "OXA-46 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:15855521] is_a: ARO:3007720 ! OXA-46-like beta-lactamase synonym: "OXA-46" EXACT CARD_Short_Name [] synonym: "OXA-81" EXACT [] [Term] id: ARO:3001798 name: OXA-74 namespace: antibiotic_resistance def: "OXA-74 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:17634312] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-74" EXACT CARD_Short_Name [] [Term] id: ARO:3001799 name: OXA-161 namespace: antibiotic_resistance def: "OXA-161 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:19770278] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-161" EXACT CARD_Short_Name [] [Term] id: ARO:3001800 name: OXA-226 namespace: antibiotic_resistance def: "OXA-226 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:19933793] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-226" EXACT CARD_Short_Name [] [Term] id: ARO:3001801 name: OXA-147 namespace: antibiotic_resistance def: "OXA-147 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:20008045] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-147" EXACT CARD_Short_Name [] [Term] id: ARO:3001802 name: OXA-141 namespace: antibiotic_resistance def: "OXA-141 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:20482453] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-141" EXACT CARD_Short_Name [] [Term] id: ARO:3001803 name: OXA-142 namespace: antibiotic_resistance def: "OXA-142 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:20482453] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-142" EXACT CARD_Short_Name [] [Term] id: ARO:3001804 name: OXA-145 namespace: antibiotic_resistance def: "OXA-145 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:21665906] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-145" EXACT CARD_Short_Name [] [Term] id: ARO:3001805 name: OXA-198 namespace: antibiotic_resistance def: "OXA-198 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:21788473] is_a: ARO:3007703 ! OXA-198-like beta-lactamase synonym: "OXA-198" EXACT CARD_Short_Name [] [Term] id: ARO:3001806 name: OXA-224 namespace: antibiotic_resistance def: "OXA-224 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:22290962] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-224" EXACT CARD_Short_Name [] [Term] id: ARO:3001807 name: OXA-246 namespace: antibiotic_resistance def: "OXA-246 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:24398232] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-246" EXACT CARD_Short_Name [] [Term] id: ARO:3001808 name: OXA-60 namespace: antibiotic_resistance def: "OXA-60 is a beta-lactamase found in Ralstonia pickettii." [PMID:15504844] is_a: ARO:3007729 ! OXA-60-like beta-lactamase synonym: "OXA-60" EXACT CARD_Short_Name [] [Term] id: ARO:3001809 name: OXA-209 namespace: antibiotic_resistance def: "OXA-209 is a beta-lactamase found in Riemerella anatipestifer." [PMID:21820820] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-209" EXACT CARD_Short_Name [] [Term] id: ARO:3001810 name: OXA-53 namespace: antibiotic_resistance def: "OXA-53 is a beta-lactamase found in Salmonella enterica." [PMID:15231768] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-53" EXACT CARD_Short_Name [] [Term] id: ARO:3001811 name: OXA-129 namespace: antibiotic_resistance def: "OXA-129 is a beta-lactamase found in Salmonella enterica." [PMID:18571903] is_a: ARO:3007723 ! OXA-5-like beta-lactamase synonym: "OXA-129" EXACT CARD_Short_Name [] [Term] id: ARO:3001812 name: OXA-54 namespace: antibiotic_resistance def: "OXA-54 is a beta-lactamase found in Shewanella spp." [PMID:14693565] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-54" EXACT CARD_Short_Name [] [Term] id: ARO:3001813 name: OXA-55 namespace: antibiotic_resistance def: "OXA-55 is a beta-lactamase found in Shewanella spp." [PMID:15105119] is_a: ARO:3007727 ! OXA-55-like beta-lactamase synonym: "OXA-55" EXACT CARD_Short_Name [] [Term] id: ARO:3001814 name: OXA-199 namespace: antibiotic_resistance def: "OXA-199 is a beta-lactamase found in Shewanella spp." [PMID:23110226] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-199" EXACT CARD_Short_Name [] [Term] id: ARO:3001815 name: ACC-1 namespace: antibiotic_resistance def: "ACC-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:10428914] is_a: ARO:3000073 ! ACC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3004004 ! cefotetan relationship: confers_resistance_to_antibiotic ARO:3004014 ! flomoxef relationship: confers_resistance_to_antibiotic ARO:3004017 ! moxalactam relationship: confers_resistance_to_antibiotic ARO:3004726 ! cefpirome synonym: "ACC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3001816 name: ACC-2 namespace: antibiotic_resistance def: "ACC-2 is a beta-lactamase found in Hafnia alvei." [PMID:10817695] is_a: ARO:3000073 ! ACC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime synonym: "ACC-2" EXACT CARD_Short_Name [] [Term] id: ARO:3001817 name: ACC-3 namespace: antibiotic_resistance def: "ACC-3 is a beta-lactamase found in Hafnia alvei." [PMID:10817695] is_a: ARO:3000073 ! ACC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "ACC-3" EXACT CARD_Short_Name [] [Term] id: ARO:3001818 name: ACC-4 namespace: antibiotic_resistance def: "ACC-4 is a beta-lactamase found in Escherichia coli." [PMID:17664321] is_a: ARO:3000073 ! ACC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime synonym: "ACC-4" EXACT CARD_Short_Name [] [Term] id: ARO:3001819 name: ACC-5 namespace: antibiotic_resistance def: "ACC-5 is a beta-lactamase. From the Lahey list of ACC beta-lactamases. It is detected among Gram-negative bacteria isolates (Gamma- and Alpha-proteobacteria) from urban water sources." [PMID:24267783] is_a: ARO:3000073 ! ACC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "ACC-5" EXACT CARD_Short_Name [] [Term] id: ARO:3001821 name: ACT-1 namespace: antibiotic_resistance def: "ACT-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:9055993] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-1" EXACT CARD_Short_Name [] [Term] id: ARO:3001822 name: ACT-2 namespace: antibiotic_resistance def: "ACT-2 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:23093031] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-2" EXACT CARD_Short_Name [] [Term] id: ARO:3001823 name: ACT-3 namespace: antibiotic_resistance def: "ACT-3 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:18789849] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-3" EXACT CARD_Short_Name [] [Term] id: ARO:3001824 name: ACT-5 namespace: antibiotic_resistance def: "ACT-5 is a beta-lactamase found in Escherichia coli." [PMID:23643553] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-5" EXACT CARD_Short_Name [] [Term] id: ARO:3001825 name: ACT-6 namespace: antibiotic_resistance def: "ACT-6 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:21304534] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-6" EXACT CARD_Short_Name [] [Term] id: ARO:3001826 name: ACT-9 namespace: antibiotic_resistance def: "ACT-9 is a beta-lactamase found in Pantoea agglomerans." [PMID:21690276] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-9" EXACT CARD_Short_Name [] [Term] id: ARO:3001827 name: ACT-16 namespace: antibiotic_resistance def: "ACT-16 is a beta-lactamase found in Enterobacteriaceae." [PMID:24336426] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-16" EXACT CARD_Short_Name [] [Term] id: ARO:3001828 name: ACT-23 namespace: antibiotic_resistance def: "ACT-23 is a beta-lactamase found in Escherichia coli." [PMID:24629772] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-23" EXACT CARD_Short_Name [] [Term] id: ARO:3001829 name: ACT-4 namespace: antibiotic_resistance def: "ACT-4 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-4" EXACT CARD_Short_Name [] [Term] id: ARO:3001830 name: ACT-7 namespace: antibiotic_resistance def: "ACT-7 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-7" EXACT CARD_Short_Name [] [Term] id: ARO:3001831 name: ACT-8 namespace: antibiotic_resistance def: "ACT-8 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-8" EXACT CARD_Short_Name [] [Term] id: ARO:3001832 name: ACT-10 namespace: antibiotic_resistance def: "ACT-10 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [PMID:25312010] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-10" EXACT CARD_Short_Name [] [Term] id: ARO:3001833 name: ACT-11 namespace: antibiotic_resistance def: "ACT-11 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase [Term] id: ARO:3001834 name: ACT-12 namespace: antibiotic_resistance def: "ACT-12 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-12" EXACT CARD_Short_Name [] [Term] id: ARO:3001835 name: ACT-13 namespace: antibiotic_resistance def: "ACT-13 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-13" EXACT CARD_Short_Name [] [Term] id: ARO:3001836 name: ACT-14 namespace: antibiotic_resistance def: "ACT-14 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-14" EXACT CARD_Short_Name [] [Term] id: ARO:3001837 name: ACT-15 namespace: antibiotic_resistance def: "ACT-15 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-15" EXACT CARD_Short_Name [] [Term] id: ARO:3001838 name: ACT-17 namespace: antibiotic_resistance def: "ACT-17 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-17" EXACT CARD_Short_Name [] [Term] id: ARO:3001839 name: ACT-18 namespace: antibiotic_resistance def: "ACT-18 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-18" EXACT CARD_Short_Name [] [Term] id: ARO:3001840 name: ACT-19 namespace: antibiotic_resistance def: "ACT-19 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-19" EXACT CARD_Short_Name [] [Term] id: ARO:3001841 name: ACT-20 namespace: antibiotic_resistance def: "ACT-20 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-20" EXACT CARD_Short_Name [] [Term] id: ARO:3001842 name: ACT-21 namespace: antibiotic_resistance def: "ACT-21 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-21" EXACT CARD_Short_Name [] [Term] id: ARO:3001843 name: ACT-22 namespace: antibiotic_resistance def: "ACT-22 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-22" EXACT CARD_Short_Name [] [Term] id: ARO:3001844 name: ACT-24 namespace: antibiotic_resistance def: "ACT-24 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-24" EXACT CARD_Short_Name [] [Term] id: ARO:3001845 name: ACT-25 namespace: antibiotic_resistance def: "ACT-25 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-25" EXACT CARD_Short_Name [] [Term] id: ARO:3001847 name: ACT-27 namespace: antibiotic_resistance def: "ACT-27 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-27" EXACT CARD_Short_Name [] [Term] id: ARO:3001848 name: ACT-28 namespace: antibiotic_resistance def: "ACT-28 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-28" EXACT CARD_Short_Name [] [Term] id: ARO:3001849 name: ACT-29 namespace: antibiotic_resistance def: "ACT-29 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-29" EXACT CARD_Short_Name [] [Term] id: ARO:3001850 name: ACT-30 namespace: antibiotic_resistance def: "ACT-30 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-30" EXACT CARD_Short_Name [] [Term] id: ARO:3001851 name: ACT-31 namespace: antibiotic_resistance def: "ACT-31 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-31" EXACT CARD_Short_Name [] [Term] id: ARO:3001852 name: ACT-32 namespace: antibiotic_resistance def: "ACT-32 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-32" EXACT CARD_Short_Name [] [Term] id: ARO:3001853 name: ACT-33 namespace: antibiotic_resistance def: "ACT-33 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-33" EXACT CARD_Short_Name [] [Term] id: ARO:3001854 name: ACT-34 namespace: antibiotic_resistance def: "ACT-34 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-34" EXACT CARD_Short_Name [] [Term] id: ARO:3001855 name: ACT-35 namespace: antibiotic_resistance def: "ACT-35 is a beta-lactamase. From the Lahey list of ACT beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-35" EXACT CARD_Short_Name [] [Term] id: ARO:3001856 name: CFE-1 namespace: antibiotic_resistance def: "CFE-1 is a beta-lactamase found in Escherichia coli." [PMID:15047515] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CFE-1" EXACT CARD_Short_Name [] [Term] id: ARO:3001857 name: LAT-1 namespace: antibiotic_resistance def: "LAT-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:7811049] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "LAT-1" EXACT CARD_Short_Name [] synonym: "LAT-4" EXACT [] [Term] id: ARO:3001858 name: IMI-1 namespace: antibiotic_resistance def: "IMI-1 is a beta-lactamase found in Enterobacter cloacae." [PMID:8878585] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-1" EXACT CARD_Short_Name [] [Term] id: ARO:3001859 name: IMI-2 namespace: antibiotic_resistance def: "IMI-2 is a beta-lactamase found in Enterobacteriaceae." [PMID:15752444, PMID:21192875] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-2" EXACT CARD_Short_Name [] [Term] id: ARO:3001860 name: IMI-3 namespace: antibiotic_resistance def: "IMI-3 is a beta-lactamase found in Enterobacteriaceae." [PMID:21192875] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-3" EXACT CARD_Short_Name [] [Term] id: ARO:3001861 name: IMI-4 namespace: antibiotic_resistance def: "IMI-4 is a beta-lactamase. From the Lahey list of IMI beta-lactamases." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-4" EXACT CARD_Short_Name [] [Term] id: ARO:3001862 name: IMI-5 namespace: antibiotic_resistance def: "IMI-5 is a beta-lactamase. From the Lahey list of IMI beta-lactamases." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-5" EXACT CARD_Short_Name [] [Term] id: ARO:3001863 name: IMI-6 namespace: antibiotic_resistance def: "IMI-6 is a beta-lactamase. From the Lahey list of IMI beta-lactamases." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-6" EXACT CARD_Short_Name [] [Term] id: ARO:3001864 name: CTX-M-1 namespace: antibiotic_resistance def: "CTX-M-1 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:8834913] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-1" EXACT CARD_Short_Name [] synonym: "MEN-1" EXACT [] [Term] id: ARO:3001865 name: CTX-M-2 namespace: antibiotic_resistance def: "CTX-M-2 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:8834913] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-2" EXACT CARD_Short_Name [] [Term] id: ARO:3001866 name: CTX-M-3 namespace: antibiotic_resistance def: "CTX-M-3 is a beta-lactamase found in Citrobacter freundii." [PMID:33416461, PMID:9559791] is_a: ARO:3000016 ! CTX-M beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000646 ! cefixime relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "CTX-M-133" EXACT [] synonym: "CTX-M-3" EXACT CARD_Short_Name [] [Term] id: ARO:3001867 name: CTX-M-4 namespace: antibiotic_resistance def: "CTX-M-4 is a beta-lactamase found in Salmonella typhimurium." [PMID:9593162] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-4" EXACT CARD_Short_Name [] [Term] id: ARO:3001868 name: CTX-M-5 namespace: antibiotic_resistance def: "CTX-M-5 is a beta-lactamase found in Salmonella typhimurium." [PMID:9687393] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-5" EXACT CARD_Short_Name [] [Term] id: ARO:3001869 name: CTX-M-6 namespace: antibiotic_resistance def: "CTX-M-6 is a beta-lactamase found in Salmonella typhimurium." [PMID:9742701] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-6" EXACT CARD_Short_Name [] [Term] id: ARO:3001870 name: CTX-M-7 namespace: antibiotic_resistance def: "CTX-M-7 is a beta-lactamase found in Salmonella typhimurium." [PMID:9742701] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-7" EXACT CARD_Short_Name [] [Term] id: ARO:3001871 name: CTX-M-8 namespace: antibiotic_resistance def: "CTX-M-8 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:10858358] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-8" EXACT CARD_Short_Name [] [Term] id: ARO:3001872 name: CTX-M-9 namespace: antibiotic_resistance def: "CTX-M-9 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:11850241] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-9" EXACT CARD_Short_Name [] [Term] id: ARO:3001873 name: CTX-M-10 namespace: antibiotic_resistance def: "CTX-M-10 is a beta-lactamase found in Escherichia coli." [PMID:11158766] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-10" EXACT CARD_Short_Name [] [Term] id: ARO:3001874 name: CTX-M-11 namespace: antibiotic_resistance def: "CTX-M-11 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-11" EXACT CARD_Short_Name [] [Term] id: ARO:3001875 name: CTX-M-12 namespace: antibiotic_resistance def: "CTX-M-12 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:11408239] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-12" EXACT CARD_Short_Name [] [Term] id: ARO:3001876 name: CTX-M-13 namespace: antibiotic_resistance def: "CTX-M-13 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:11850241] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-13" EXACT CARD_Short_Name [] [Term] id: ARO:3001877 name: CTX-M-14 namespace: antibiotic_resistance def: "CTX-M-14 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:11850241] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-14" EXACT CARD_Short_Name [] synonym: "CTX-M-18" EXACT [] [Term] id: ARO:3001878 name: CTX-M-15 namespace: antibiotic_resistance def: "CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:11470367, PMID:12461028, PMID:33416461] is_a: ARO:3000016 ! CTX-M beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "CTX-M-15" EXACT CARD_Short_Name [] synonym: "UOE-1" EXACT [] [Term] id: ARO:3001879 name: CTX-M-16 namespace: antibiotic_resistance def: "CTX-M-16 is a beta-lactamase found in Escherichia coli." [PMID:11451684] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-16" EXACT CARD_Short_Name [] [Term] id: ARO:3001880 name: CTX-M-17 namespace: antibiotic_resistance def: "CTX-M-17 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:11959547] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-17" EXACT CARD_Short_Name [] [Term] id: ARO:3001881 name: CTX-M-19 namespace: antibiotic_resistance def: "CTX-M-19 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:11709308] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-19" EXACT CARD_Short_Name [] [Term] id: ARO:3001882 name: CTX-M-20 namespace: antibiotic_resistance def: "CTX-M-20 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:12007800] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-20" EXACT CARD_Short_Name [] [Term] id: ARO:3001883 name: CTX-M-21 namespace: antibiotic_resistance def: "CTX-M-21 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:12007800] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-21" EXACT CARD_Short_Name [] [Term] id: ARO:3001884 name: CTX-M-22 namespace: antibiotic_resistance def: "CTX-M-22 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16533535] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-22" EXACT CARD_Short_Name [] [Term] id: ARO:3001885 name: CTX-M-23 namespace: antibiotic_resistance def: "CTX-M-23 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:15201232] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-23" EXACT CARD_Short_Name [] [Term] id: ARO:3001886 name: CTX-M-24 namespace: antibiotic_resistance def: "CTX-M-24 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16291869] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-24" EXACT CARD_Short_Name [] [Term] id: ARO:3001887 name: CTX-M-25 namespace: antibiotic_resistance def: "CTX-M-25 is a beta-lactamase found in Escherichia coli." [PMID:15561863] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-25" EXACT CARD_Short_Name [] [Term] id: ARO:3001888 name: CTX-M-26 namespace: antibiotic_resistance def: "CTX-M-26 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15561863] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-26" EXACT CARD_Short_Name [] [Term] id: ARO:3001889 name: CTX-M-27 namespace: antibiotic_resistance def: "CTX-M-27 is a beta-lactamase found in Escherichia coli." [PMID:12775683, PMID:33416461] is_a: ARO:3000016 ! CTX-M beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000646 ! cefixime relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "CTX-M-27" EXACT CARD_Short_Name [] [Term] id: ARO:3001890 name: CTX-M-28 namespace: antibiotic_resistance def: "CTX-M-28 is a beta-lactamase found in Salmonella enterica." [PMID:15941775] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-28" EXACT CARD_Short_Name [] [Term] id: ARO:3001891 name: CTX-M-29 namespace: antibiotic_resistance def: "CTX-M-29 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16533535] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-29" EXACT CARD_Short_Name [] [Term] id: ARO:3001892 name: CTX-M-30 namespace: antibiotic_resistance def: "CTX-M-30 is a beta-lactamase found in Citrobacter freundii." [PMID:15504875] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-30" EXACT CARD_Short_Name [] [Term] id: ARO:3001893 name: CTX-M-31 namespace: antibiotic_resistance def: "CTX-M-31 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:12936986] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-31" EXACT CARD_Short_Name [] [Term] id: ARO:3001894 name: CTX-M-32 namespace: antibiotic_resistance def: "CTX-M-32 is a beta-lactamase found in Escherichia coli." [PMID:15155242] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-32" EXACT CARD_Short_Name [] [Term] id: ARO:3001895 name: CTX-M-33 namespace: antibiotic_resistance def: "CTX-M-33 is a beta-lactamase found in Salmonella enterica." [PMID:17234386] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-33" EXACT CARD_Short_Name [] [Term] id: ARO:3001896 name: CTX-M-34 namespace: antibiotic_resistance def: "CTX-M-34 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16244084] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-34" EXACT CARD_Short_Name [] [Term] id: ARO:3001897 name: CTX-M-35 namespace: antibiotic_resistance def: "CTX-M-35 is a beta-lactamase found in Citrobacter koseri." [PMID:20138478] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-35" EXACT CARD_Short_Name [] [Term] id: ARO:3001898 name: CTX-M-36 namespace: antibiotic_resistance def: "CTX-M-36 is a beta-lactamase found in Escherichia coli." [PMID:21940649] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-36" EXACT CARD_Short_Name [] [Term] id: ARO:3001899 name: CTX-M-37 namespace: antibiotic_resistance def: "CTX-M-37 is a beta-lactamase found in Salmonella enterica." [PMID:16949257] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-37" EXACT CARD_Short_Name [] [Term] id: ARO:3001900 name: CTX-M-38 namespace: antibiotic_resistance def: "CTX-M-38 is a beta-lactamase found in Escherichia coli." [PMID:19927355] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-38" EXACT CARD_Short_Name [] [Term] id: ARO:3001901 name: CTX-M-39 namespace: antibiotic_resistance def: "CTX-M-39 is a beta-lactamase found in Escherichia coli." [PMID:16251320] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-39" EXACT CARD_Short_Name [] [Term] id: ARO:3001902 name: CTX-M-40 namespace: antibiotic_resistance def: "CTX-M-40 is a beta-lactamase found in Escherichia coli." [PMID:16697557] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-40" EXACT CARD_Short_Name [] [Term] id: ARO:3001903 name: CTX-M-41 namespace: antibiotic_resistance def: "CTX-M-41 is a beta-lactamase found in Proteus mirabilis." [PMID:18487232] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-41" EXACT CARD_Short_Name [] [Term] id: ARO:3001904 name: CTX-M-42 namespace: antibiotic_resistance def: "CTX-M-42 is a beta-lactamase found in Escherichia coli." [PMID:18212109] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-42" EXACT CARD_Short_Name [] [Term] id: ARO:3001905 name: CTX-M-43 namespace: antibiotic_resistance def: "CTX-M-43 is a beta-lactamase found in Pseudomonas aeruginosa and Acinetobacter spp." [PMID:16510850] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-43" EXACT CARD_Short_Name [] [Term] id: ARO:3001906 name: CTX-M-44 namespace: antibiotic_resistance def: "CTX-M-44 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:21078949] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-44" EXACT CARD_Short_Name [] synonym: "Toho-1" EXACT [] [Term] id: ARO:3001907 name: CTX-M-45 namespace: antibiotic_resistance def: "CTX-M-45 is a beta-lactamase found in Escherichia coli." [PMID:9593147] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-45" EXACT CARD_Short_Name [] synonym: "Toho-2" EXACT [] [Term] id: ARO:3001908 name: CTX-M-46 namespace: antibiotic_resistance def: "CTX-M-46 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16082008] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-46" EXACT CARD_Short_Name [] [Term] id: ARO:3001909 name: CTX-M-47 namespace: antibiotic_resistance def: "CTX-M-47 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16082008] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-47" EXACT CARD_Short_Name [] [Term] id: ARO:3001910 name: CTX-M-48 namespace: antibiotic_resistance def: "CTX-M-48 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16082008] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-48" EXACT CARD_Short_Name [] [Term] id: ARO:3001911 name: CTX-M-49 namespace: antibiotic_resistance def: "CTX-M-49 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16082008] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-49" EXACT CARD_Short_Name [] [Term] id: ARO:3001912 name: CTX-M-50 namespace: antibiotic_resistance def: "CTX-M-50 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16082008] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-50" EXACT CARD_Short_Name [] [Term] id: ARO:3001913 name: CTX-M-51 namespace: antibiotic_resistance def: "CTX-M-51 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-51" EXACT CARD_Short_Name [] [Term] id: ARO:3001914 name: CTX-M-52 namespace: antibiotic_resistance def: "CTX-M-52 is a beta-lactamase found in Escherichia coli." [PMID:15736704] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-52" EXACT CARD_Short_Name [] [Term] id: ARO:3001915 name: CTX-M-53 namespace: antibiotic_resistance def: "CTX-M-53 is a beta-lactamase found in Salmonella enterica." [PMID:19273683] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-53" EXACT CARD_Short_Name [] [Term] id: ARO:3001916 name: CTX-M-54 namespace: antibiotic_resistance def: "CTX-M-54 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16785225] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-54" EXACT CARD_Short_Name [] [Term] id: ARO:3001917 name: CTX-M-55 namespace: antibiotic_resistance def: "CTX-M-55 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:17449211] is_a: ARO:3000016 ! CTX-M beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone synonym: "CTX-M-55" EXACT CARD_Short_Name [] synonym: "CTX-M-57" EXACT [] [Term] id: ARO:3001918 name: CTX-M-56 namespace: antibiotic_resistance def: "CTX-M-56 is a beta-lactamase found in Escherichia coli." [PMID:17548490] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-56" EXACT CARD_Short_Name [] [Term] id: ARO:3001919 name: CTX-M-58 namespace: antibiotic_resistance def: "CTX-M-58 is a beta-lactamase found in Escherichia coli." [PMID:21788458] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-58" EXACT CARD_Short_Name [] [Term] id: ARO:3001920 name: CTX-M-59 namespace: antibiotic_resistance def: "CTX-M-59 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:18347108] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-59" EXACT CARD_Short_Name [] [Term] id: ARO:3001921 name: CTX-M-60 namespace: antibiotic_resistance def: "CTX-M-60 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-60" EXACT CARD_Short_Name [] [Term] id: ARO:3001922 name: CTX-M-61 namespace: antibiotic_resistance def: "CTX-M-61 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:17804424] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-61" EXACT CARD_Short_Name [] [Term] id: ARO:3001923 name: CTX-M-62 namespace: antibiotic_resistance def: "CTX-M-62 is a beta-lactamase found in Escherichia coli." [PMID:18725449] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-62" EXACT CARD_Short_Name [] [Term] id: ARO:3001924 name: CTX-M-63 namespace: antibiotic_resistance def: "CTX-M-63 is a beta-lactamase found in Salmonella enterica." [PMID:21034262] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-63" EXACT CARD_Short_Name [] [Term] id: ARO:3001925 name: CTX-M-64 namespace: antibiotic_resistance def: "CTX-M-64 is a beta-lactamase found in Shigella sonnei." [PMID:18955524] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-64" EXACT CARD_Short_Name [] [Term] id: ARO:3001926 name: CTX-M-65 namespace: antibiotic_resistance def: "CTX-M-65 is a beta-lactamase found in Escherichia coli." [PMID:18195064] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-65" EXACT CARD_Short_Name [] [Term] id: ARO:3001927 name: CTX-M-66 namespace: antibiotic_resistance def: "CTX-M-66 is a beta-lactamase found in Proteus mirabilis." [PMID:17913434] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-66" EXACT CARD_Short_Name [] [Term] id: ARO:3001928 name: CTX-M-67 namespace: antibiotic_resistance def: "CTX-M-67 is a beta-lactamase found in Escherichia coli." [PMID:18775649] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-67" EXACT CARD_Short_Name [] [Term] id: ARO:3001929 name: CTX-M-68 namespace: antibiotic_resistance def: "CTX-M-68 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19748232] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-68" EXACT CARD_Short_Name [] [Term] id: ARO:3001930 name: CTX-M-69 namespace: antibiotic_resistance def: "CTX-M-69 is a beta-lactamase found in Escherichia coli." [PMID:21940649] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-69" EXACT CARD_Short_Name [] [Term] id: ARO:3001931 name: CTX-M-70 namespace: antibiotic_resistance def: "CTX-M-70 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase [Term] id: ARO:3001932 name: CTX-M-71 namespace: antibiotic_resistance def: "CTX-M-71 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19620330] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-71" EXACT CARD_Short_Name [] [Term] id: ARO:3001933 name: CTX-M-72 namespace: antibiotic_resistance def: "CTX-M-72 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19590148] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-72" EXACT CARD_Short_Name [] [Term] id: ARO:3001934 name: CTX-M-73 namespace: antibiotic_resistance def: "CTX-M-73 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-73" EXACT CARD_Short_Name [] [Term] id: ARO:3001935 name: CTX-M-74 namespace: antibiotic_resistance def: "CTX-M-74 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19748435] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-74" EXACT CARD_Short_Name [] [Term] id: ARO:3001936 name: CTX-M-75 namespace: antibiotic_resistance def: "CTX-M-75 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19748435] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-75" EXACT CARD_Short_Name [] [Term] id: ARO:3001937 name: CTX-M-76 namespace: antibiotic_resistance def: "CTX-M-76 is a beta-lactamase found in Kluyvera spp." [PMID:22697133] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-76" EXACT CARD_Short_Name [] [Term] id: ARO:3001938 name: CTX-M-77 namespace: antibiotic_resistance def: "CTX-M-77 is a beta-lactamase found in Kluyvera spp." [PMID:22697133] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-77" EXACT CARD_Short_Name [] [Term] id: ARO:3001939 name: CTX-M-78 namespace: antibiotic_resistance def: "CTX-M-78 is a beta-lactamase found in Kluyvera georgiana." [PMID:20421403] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-78" EXACT CARD_Short_Name [] [Term] id: ARO:3001940 name: CTX-M-79 namespace: antibiotic_resistance def: "CTX-M-79 is a beta-lactamase found in Escherichia coli." [PMID:18772941] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-79" EXACT CARD_Short_Name [] [Term] id: ARO:3001941 name: CTX-M-80 namespace: antibiotic_resistance def: "CTX-M-80 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19294528] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-80" EXACT CARD_Short_Name [] [Term] id: ARO:3001942 name: CTX-M-81 namespace: antibiotic_resistance def: "CTX-M-81 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19294528] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-81" EXACT CARD_Short_Name [] [Term] id: ARO:3001943 name: CTX-M-82 namespace: antibiotic_resistance def: "CTX-M-82 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19297379] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-82" EXACT CARD_Short_Name [] [Term] id: ARO:3001944 name: CTX-M-83 namespace: antibiotic_resistance def: "CTX-M-83 is a beta-lactamase found in Salmonella enterica." [PMID:18984647] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-83" EXACT CARD_Short_Name [] [Term] id: ARO:3001945 name: CTX-M-84 namespace: antibiotic_resistance def: "CTX-M-84 is a beta-lactamase found in Salmonella enterica." [PMID:18984647] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-84" EXACT CARD_Short_Name [] [Term] id: ARO:3001946 name: CTX-M-86 namespace: antibiotic_resistance def: "CTX-M-86 is a beta-lactamase found in Salmonella enterica." [PMID:18984647] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-86" EXACT CARD_Short_Name [] [Term] id: ARO:3001947 name: CTX-M-87 namespace: antibiotic_resistance def: "CTX-M-87 is a beta-lactamase found in Escherichia coli." [PMID:19429759] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-87" EXACT CARD_Short_Name [] [Term] id: ARO:3001948 name: CTX-M-88 namespace: antibiotic_resistance def: "CTX-M-88 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-88" EXACT CARD_Short_Name [] [Term] id: ARO:3001949 name: CTX-M-89 namespace: antibiotic_resistance def: "CTX-M-89 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19587301] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-89" EXACT CARD_Short_Name [] [Term] id: ARO:3001950 name: CTX-M-90 namespace: antibiotic_resistance def: "CTX-M-90 is a beta-lactamase found in Proteus mirabilis." [PMID:21282448] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-90" EXACT CARD_Short_Name [] [Term] id: ARO:3001951 name: CTX-M-91 namespace: antibiotic_resistance def: "CTX-M-91 is a beta-lactamase found in Escherichia coli." [PMID:22450980] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-91" EXACT CARD_Short_Name [] [Term] id: ARO:3001952 name: CTX-M-92 namespace: antibiotic_resistance def: "CTX-M-92 is a beta-lactamase found in Escherichia coli." [PMID:24589574] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-92" EXACT CARD_Short_Name [] [Term] id: ARO:3001953 name: CTX-M-93 namespace: antibiotic_resistance def: "CTX-M-93 is a beta-lactamase found in Escherichia coli." [PMID:21343457] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-93" EXACT CARD_Short_Name [] [Term] id: ARO:3001954 name: CTX-M-94 namespace: antibiotic_resistance def: "CTX-M-94 is a beta-lactamase found in Escherichia coli." [PMID:23050014] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-94" EXACT CARD_Short_Name [] [Term] id: ARO:3001955 name: CTX-M-95 namespace: antibiotic_resistance def: "CTX-M-95 is a beta-lactamase found in Kluyvera spp." [PMID:22697133] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-95" EXACT CARD_Short_Name [] [Term] id: ARO:3001956 name: CTX-M-96 namespace: antibiotic_resistance def: "CTX-M-96 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-96" EXACT CARD_Short_Name [] [Term] id: ARO:3001957 name: CTX-M-98 namespace: antibiotic_resistance def: "CTX-M-98 is a beta-lactamase found in Escherichia coli." [PMID:22325120] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-98" EXACT CARD_Short_Name [] [Term] id: ARO:3001958 name: CTX-M-99 namespace: antibiotic_resistance def: "CTX-M-99 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:23034125] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-99" EXACT CARD_Short_Name [] [Term] id: ARO:3001959 name: CTX-M-100 namespace: antibiotic_resistance def: "CTX-M-100 is a beta-lactamase found in Escherichia coli." [PMID:23050014] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-100" EXACT CARD_Short_Name [] [Term] id: ARO:3001960 name: CTX-M-101 namespace: antibiotic_resistance def: "CTX-M-101 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-101" EXACT CARD_Short_Name [] [Term] id: ARO:3001961 name: CTX-M-102 namespace: antibiotic_resistance def: "CTX-M-102 is a beta-lactamase found in Escherichia coli." [PMID:22325120] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-102" EXACT CARD_Short_Name [] [Term] id: ARO:3001962 name: CTX-M-103 namespace: antibiotic_resistance def: "CTX-M-103 is a beta-lactamase found in Escherichia coli." [PMID:23926164] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-103" EXACT CARD_Short_Name [] [Term] id: ARO:3001963 name: CTX-M-104 namespace: antibiotic_resistance def: "CTX-M-104 is a beta-lactamase found in Escherichia coli." [PMID:22325120] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-104" EXACT CARD_Short_Name [] [Term] id: ARO:3001965 name: CTX-M-105 namespace: antibiotic_resistance def: "CTX-M-105 is a beta-lactamase found in Escherichia coli." [PMID:22407683] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-105" EXACT CARD_Short_Name [] [Term] id: ARO:3001966 name: CTX-M-106 namespace: antibiotic_resistance def: "CTX-M-106 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-106" EXACT CARD_Short_Name [] [Term] id: ARO:3001967 name: CTX-M-107 namespace: antibiotic_resistance def: "CTX-M-107 is a beta-lactamase found in Shigella spp." [PMID:21859815] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-107" EXACT CARD_Short_Name [] [Term] id: ARO:3001968 name: CTX-M-108 namespace: antibiotic_resistance def: "CTX-M-108 is a beta-lactamase found in Shigella spp." [PMID:21859815] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-108" EXACT CARD_Short_Name [] [Term] id: ARO:3001969 name: CTX-M-109 namespace: antibiotic_resistance def: "CTX-M-109 is a beta-lactamase found in Shigella spp." [PMID:21859815] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-109" EXACT CARD_Short_Name [] [Term] id: ARO:3001970 name: CTX-M-110 namespace: antibiotic_resistance def: "CTX-M-110 is a beta-lactamase found in Shigella spp." [PMID:21859815] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-110" EXACT CARD_Short_Name [] [Term] id: ARO:3001971 name: CTX-M-111 namespace: antibiotic_resistance def: "CTX-M-111 is a beta-lactamase found in Shigella spp." [PMID:21859815] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-111" EXACT CARD_Short_Name [] [Term] id: ARO:3001972 name: CTX-M-112 namespace: antibiotic_resistance def: "CTX-M-112 is a beta-lactamase found in Shigella spp." [PMID:21859815] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-112" EXACT CARD_Short_Name [] [Term] id: ARO:3001973 name: CTX-M-113 namespace: antibiotic_resistance def: "CTX-M-113 is a beta-lactamase found in Shigella spp." [PMID:21859815] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-113" EXACT CARD_Short_Name [] [Term] id: ARO:3001974 name: CTX-M-114 namespace: antibiotic_resistance def: "CTX-M-114 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-114" EXACT CARD_Short_Name [] [Term] id: ARO:3001975 name: CTX-M-115 namespace: antibiotic_resistance def: "CTX-M-115 is a beta-lactamase found in Acinetobacter baumannii." [PMID:23982021] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-115" EXACT CARD_Short_Name [] [Term] id: ARO:3001976 name: CTX-M-116 namespace: antibiotic_resistance def: "CTX-M-116 is a beta-lactamase found in Proteus mirabilis." [PMID:23318795] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-116" EXACT CARD_Short_Name [] [Term] id: ARO:3001977 name: CTX-M-117 namespace: antibiotic_resistance def: "CTX-M-117 is a beta-lactamase found in Escherichia coli." [PMID:23127481] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-117" EXACT CARD_Short_Name [] [Term] id: ARO:3001978 name: CTX-M-119 namespace: antibiotic_resistance def: "CTX-M-119 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase [Term] id: ARO:3001979 name: CTX-M-120 namespace: antibiotic_resistance def: "CTX-M-120 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase [Term] id: ARO:3001980 name: CTX-M-121 namespace: antibiotic_resistance def: "CTX-M-121 is a beta-lactamase found in Escherichia coli." [PMID:23892737] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-121" EXACT CARD_Short_Name [] [Term] id: ARO:3001981 name: CTX-M-122 namespace: antibiotic_resistance def: "CTX-M-122 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-122" EXACT CARD_Short_Name [] [Term] id: ARO:3001982 name: CTX-M-123 namespace: antibiotic_resistance def: "CTX-M-123 is a beta-lactamase found in Escherichia coli." [PMID:23752509] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-123" EXACT CARD_Short_Name [] [Term] id: ARO:3001983 name: CTX-M-124 namespace: antibiotic_resistance def: "CTX-M-124 is a beta-lactamase found in Escherichia coli." [PMID:22314536] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-124" EXACT CARD_Short_Name [] [Term] id: ARO:3001984 name: CTX-M-125 namespace: antibiotic_resistance def: "CTX-M-125 is a beta-lactamase found in Escherichia coli." [PMID:24040123] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-125" EXACT CARD_Short_Name [] [Term] id: ARO:3001985 name: CTX-M-126 namespace: antibiotic_resistance def: "CTX-M-126 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-126" EXACT CARD_Short_Name [] [Term] id: ARO:3001986 name: CTX-M-127 namespace: antibiotic_resistance def: "CTX-M-127 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-127" EXACT CARD_Short_Name [] [Term] id: ARO:3001987 name: CTX-M-128 namespace: antibiotic_resistance def: "CTX-M-128 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase [Term] id: ARO:3001988 name: CTX-M-129 namespace: antibiotic_resistance def: "CTX-M-129 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-129" EXACT CARD_Short_Name [] [Term] id: ARO:3001989 name: CTX-M-130 namespace: antibiotic_resistance def: "CTX-M-130 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-130" EXACT CARD_Short_Name [] [Term] id: ARO:3001990 name: CTX-M-131 namespace: antibiotic_resistance def: "CTX-M-131 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-131" EXACT CARD_Short_Name [] [Term] id: ARO:3001991 name: CTX-M-132 namespace: antibiotic_resistance def: "CTX-M-132 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-132" EXACT CARD_Short_Name [] [Term] id: ARO:3001992 name: CTX-M-134 namespace: antibiotic_resistance def: "CTX-M-134 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-134" EXACT CARD_Short_Name [] [Term] id: ARO:3001993 name: CTX-M-135 namespace: antibiotic_resistance def: "CTX-M-135 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:24637692] is_a: ARO:3000016 ! CTX-M beta-lactamase [Term] id: ARO:3001994 name: CTX-M-137 namespace: antibiotic_resistance def: "CTX-M-137 is a beta-lactamase found in Escherichia coli." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-137" EXACT CARD_Short_Name [] [Term] id: ARO:3001995 name: CTX-M-136 namespace: antibiotic_resistance def: "CTX-M-136 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-136" EXACT CARD_Short_Name [] [Term] id: ARO:3001996 name: CTX-M-138 namespace: antibiotic_resistance def: "CTX-M-138 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-138" EXACT CARD_Short_Name [] [Term] id: ARO:3001997 name: CTX-M-139 namespace: antibiotic_resistance def: "CTX-M-139 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-139" EXACT CARD_Short_Name [] [Term] id: ARO:3001998 name: CTX-M-140 namespace: antibiotic_resistance def: "CTX-M-140 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-140" EXACT CARD_Short_Name [] [Term] id: ARO:3001999 name: CTX-M-141 namespace: antibiotic_resistance def: "CTX-M-141 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-141" EXACT CARD_Short_Name [] [Term] id: ARO:3002000 name: CTX-M-142 namespace: antibiotic_resistance def: "CTX-M-142 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-142" EXACT CARD_Short_Name [] [Term] id: ARO:3002001 name: CTX-M-143 namespace: antibiotic_resistance def: "CTX-M-143 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-143" EXACT CARD_Short_Name [] [Term] id: ARO:3002002 name: CTX-M-144 namespace: antibiotic_resistance def: "CTX-M-144 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-144" EXACT CARD_Short_Name [] [Term] id: ARO:3002003 name: CTX-M-145 namespace: antibiotic_resistance def: "CTX-M-145 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase [Term] id: ARO:3002004 name: CTX-M-146 namespace: antibiotic_resistance def: "CTX-M-146 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-146" EXACT CARD_Short_Name [] [Term] id: ARO:3002005 name: CTX-M-147 namespace: antibiotic_resistance def: "CTX-M-147 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-147" EXACT CARD_Short_Name [] [Term] id: ARO:3002006 name: CTX-M-148 namespace: antibiotic_resistance def: "CTX-M-148 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-148" EXACT CARD_Short_Name [] [Term] id: ARO:3002007 name: CTX-M-150 namespace: antibiotic_resistance def: "CTX-M-150 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-150" EXACT CARD_Short_Name [] [Term] id: ARO:3002008 name: CTX-M-151 namespace: antibiotic_resistance def: "CTX-M-151 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-151" EXACT CARD_Short_Name [] [Term] id: ARO:3002009 name: CTX-M-152 namespace: antibiotic_resistance def: "CTX-M-152 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-152" EXACT CARD_Short_Name [] [Term] id: ARO:3002010 name: CTX-M-153 namespace: antibiotic_resistance def: "CTX-M-153 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-153" EXACT CARD_Short_Name [] [Term] id: ARO:3002011 name: CTX-M-154 namespace: antibiotic_resistance def: "CTX-M-154 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-154" EXACT CARD_Short_Name [] [Term] id: ARO:3002012 name: CMY-1 namespace: antibiotic_resistance def: "CMY-1 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:8843306] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002013 name: CMY-2 namespace: antibiotic_resistance def: "CMY-2 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:33416461, PMID:8787910] is_a: ARO:3000069 ! CMY beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000044 ! cephamycin relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000646 ! cefixime relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "BIL-1, LAT-2" EXACT [] synonym: "CMY-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002014 name: CMY-3 namespace: antibiotic_resistance def: "CMY-3 is a beta-lactamase found in Proteus mirabilis." [PMID:9593136] is_a: ARO:3000069 ! CMY beta-lactamase [Term] id: ARO:3002015 name: CMY-4 namespace: antibiotic_resistance def: "CMY-4 is a beta-lactamase found in Proteus mirabilis." [PMID:9868767] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002016 name: CMY-5 namespace: antibiotic_resistance def: "CMY-5 is a beta-lactamase found in Klebsiella oxytoca." [PMID:10348751] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002017 name: CMY-6 namespace: antibiotic_resistance def: "CMY-6 is a beta-lactamase found in Escherichia coli." [PMID:9818739] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-6" EXACT CARD_Short_Name [] synonym: "LAT-3" EXACT [] [Term] id: ARO:3002018 name: CMY-7 namespace: antibiotic_resistance def: "CMY-7 is a beta-lactamase found in Salmonella typhimurium." [PMID:12039894] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002019 name: CMY-8 namespace: antibiotic_resistance def: "CMY-8 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:10817689] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002020 name: CMY-9 namespace: antibiotic_resistance def: "CMY-9 is a beta-lactamase found in Escherichia coli." [PMID:12121914] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002021 name: CMY-10 namespace: antibiotic_resistance def: "CMY-10 is a beta-lactamase found in Klebsiella aerogenes." [PMID:12969288] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002022 name: CMY-11 namespace: antibiotic_resistance def: "CMY-11 is a beta-lactamase found in Escherichia coli." [PMID:11815567] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002023 name: CMY-12 namespace: antibiotic_resistance def: "CMY-12 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:12407124] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002024 name: CMY-13 namespace: antibiotic_resistance def: "CMY-13 is a beta-lactamase found in Escherichia coli." [PMID:15273143] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002025 name: CMY-14 namespace: antibiotic_resistance def: "CMY-14 is a beta-lactamase found in Proteus mirabilis." [PMID:15504832] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002026 name: CMY-15 namespace: antibiotic_resistance def: "CMY-15 is a beta-lactamase found in Proteus mirabilis." [PMID:15504832] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002027 name: CMY-16 namespace: antibiotic_resistance def: "CMY-16 is a beta-lactamase found in Proteus mirabilis." [PMID:16436718] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002028 name: CMY-17 namespace: antibiotic_resistance def: "CMY-17 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002029 name: CMY-18 namespace: antibiotic_resistance def: "CMY-18 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:16584308] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002030 name: CMY-19 namespace: antibiotic_resistance def: "CMY-19 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16436707] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002031 name: CMY-20 namespace: antibiotic_resistance def: "CMY-20 is a beta-lactamase found in Escherichia coli." [PMID:18207348] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-20" EXACT CARD_Short_Name [] [Term] id: ARO:3002032 name: CMY-21 namespace: antibiotic_resistance def: "CMY-21 is a beta-lactamase found in Escherichia coli." [PMID:16716570] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-21" EXACT CARD_Short_Name [] [Term] id: ARO:3002033 name: CMY-22 namespace: antibiotic_resistance def: "CMY-22 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-22" EXACT CARD_Short_Name [] [Term] id: ARO:3002034 name: CMY-23 namespace: antibiotic_resistance def: "CMY-23 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:17110393] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-23" EXACT CARD_Short_Name [] [Term] id: ARO:3002035 name: CMY-24 namespace: antibiotic_resistance def: "CMY-24 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:17587551] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-24" EXACT CARD_Short_Name [] [Term] id: ARO:3002036 name: CMY-25 namespace: antibiotic_resistance def: "CMY-25 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19523051] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-25" EXACT CARD_Short_Name [] [Term] id: ARO:3002037 name: CMY-26 namespace: antibiotic_resistance def: "CMY-26 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:17720829] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-26" EXACT CARD_Short_Name [] [Term] id: ARO:3002038 name: CMY-27 namespace: antibiotic_resistance def: "CMY-27 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19523051] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-27" EXACT CARD_Short_Name [] [Term] id: ARO:3002039 name: CMY-28 namespace: antibiotic_resistance def: "CMY-28 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-28" EXACT CARD_Short_Name [] [Term] id: ARO:3002040 name: CMY-29 namespace: antibiotic_resistance def: "CMY-29 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19414570] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-29" EXACT CARD_Short_Name [] [Term] id: ARO:3002041 name: CMY-30 namespace: antibiotic_resistance def: "CMY-30 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [PMID:19414570] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-30" EXACT CARD_Short_Name [] [Term] id: ARO:3002042 name: CMY-31 namespace: antibiotic_resistance def: "CMY-31 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:18065410] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-31" EXACT CARD_Short_Name [] [Term] id: ARO:3002043 name: CMY-32 namespace: antibiotic_resistance def: "CMY-32 is a beta-lactamase found in Escherichia coli." [PMID:19687234] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-32" EXACT CARD_Short_Name [] [Term] id: ARO:3002044 name: CMY-33 namespace: antibiotic_resistance def: "CMY-33 is a beta-lactamase found in Escherichia coli." [PMID:19414578] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-33" EXACT CARD_Short_Name [] [Term] id: ARO:3002045 name: CMY-34 namespace: antibiotic_resistance def: "CMY-34 is a beta-lactamase found in Escherichia coli." [PMID:21820821] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-34" EXACT CARD_Short_Name [] [Term] id: ARO:3002046 name: CMY-35 namespace: antibiotic_resistance def: "CMY-35 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-35" EXACT CARD_Short_Name [] [Term] id: ARO:3002047 name: CMY-36 namespace: antibiotic_resistance def: "CMY-36 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19104021] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-36" EXACT CARD_Short_Name [] [Term] id: ARO:3002048 name: CMY-37 namespace: antibiotic_resistance def: "CMY-37 is a beta-lactamase found in Citrobacter freundii." [PMID:18619820] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-37" EXACT CARD_Short_Name [] [Term] id: ARO:3002049 name: CMY-38 namespace: antibiotic_resistance def: "CMY-38 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:18458126] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-38" EXACT CARD_Short_Name [] [Term] id: ARO:3002050 name: CMY-39 namespace: antibiotic_resistance def: "CMY-39 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-39" EXACT CARD_Short_Name [] [Term] id: ARO:3002051 name: CMY-40 namespace: antibiotic_resistance def: "CMY-40 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19523051] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-40" EXACT CARD_Short_Name [] [Term] id: ARO:3002052 name: CMY-41 namespace: antibiotic_resistance def: "CMY-41 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19343954] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-41" EXACT CARD_Short_Name [] [Term] id: ARO:3002053 name: CMY-42 namespace: antibiotic_resistance def: "CMY-42 is a plasmid-borne AmpC cephalosporinase gene found in Escherichia coli." [PMID:21388298] is_a: ARO:3000069 ! CMY beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "CMY-42" EXACT CARD_Short_Name [] [Term] id: ARO:3002054 name: CMY-43 namespace: antibiotic_resistance def: "CMY-43 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-43" EXACT CARD_Short_Name [] [Term] id: ARO:3002055 name: CMY-44 namespace: antibiotic_resistance def: "CMY-44 is a beta-lactamase found in Escherichia coli." [PMID:19414578] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-44" EXACT CARD_Short_Name [] [Term] id: ARO:3002056 name: CMY-45 namespace: antibiotic_resistance def: "CMY-45 is a beta-lactamase found in Proteus mirabilis." [PMID:21402851] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-45" EXACT CARD_Short_Name [] [Term] id: ARO:3002057 name: CMY-46 namespace: antibiotic_resistance def: "CMY-46 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-46" EXACT CARD_Short_Name [] [Term] id: ARO:3002058 name: CMY-47 namespace: antibiotic_resistance def: "CMY-47 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-47" EXACT CARD_Short_Name [] [Term] id: ARO:3002059 name: CMY-48 namespace: antibiotic_resistance def: "CMY-48 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-48" EXACT CARD_Short_Name [] [Term] id: ARO:3002060 name: CMY-49 namespace: antibiotic_resistance def: "CMY-49 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-49" EXACT CARD_Short_Name [] [Term] id: ARO:3002061 name: CMY-50 namespace: antibiotic_resistance def: "CMY-50 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-50" EXACT CARD_Short_Name [] [Term] id: ARO:3002062 name: CMY-51 namespace: antibiotic_resistance def: "CMY-51 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-51" EXACT CARD_Short_Name [] [Term] id: ARO:3002063 name: CMY-52 namespace: antibiotic_resistance def: "CMY-52 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase [Term] id: ARO:3002064 name: CMY-53 namespace: antibiotic_resistance def: "CMY-53 is a beta-lactamase found in Escherichia coli." [PMID:21820821] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-53" EXACT CARD_Short_Name [] [Term] id: ARO:3002065 name: CMY-54 namespace: antibiotic_resistance def: "CMY-54 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:22956023, PMID:28665771] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-54" EXACT CARD_Short_Name [] [Term] id: ARO:3002066 name: CMY-55 namespace: antibiotic_resistance def: "CMY-55 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:22956023] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-55" EXACT CARD_Short_Name [] [Term] id: ARO:3002067 name: CMY-56 namespace: antibiotic_resistance def: "CMY-56 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:22956023] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-56" EXACT CARD_Short_Name [] [Term] id: ARO:3002068 name: CMY-57 namespace: antibiotic_resistance def: "CMY-57 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:22956023] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-57" EXACT CARD_Short_Name [] [Term] id: ARO:3002069 name: CMY-59 namespace: antibiotic_resistance def: "CMY-59 is a beta-lactamase found in Shigella spp." [PMID:23825726] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-59" EXACT CARD_Short_Name [] [Term] id: ARO:3002070 name: CMY-99 namespace: antibiotic_resistance def: "CMY-99 is a beta-lactamase found in Proteus mirabilis." [PMID:24165184] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-99" EXACT CARD_Short_Name [] [Term] id: ARO:3002071 name: CMY-110 namespace: antibiotic_resistance def: "CMY-110 is a beta-lactamase found in Escherichia coli." [PMID:24709044] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-110" EXACT CARD_Short_Name [] [Term] id: ARO:3002072 name: CMY-58 namespace: antibiotic_resistance def: "CMY-58 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-58" EXACT CARD_Short_Name [] [Term] id: ARO:3002073 name: CMY-60 namespace: antibiotic_resistance def: "CMY-60 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-60" EXACT CARD_Short_Name [] [Term] id: ARO:3002074 name: CMY-61 namespace: antibiotic_resistance def: "CMY-61 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-61" EXACT CARD_Short_Name [] [Term] id: ARO:3002075 name: CMY-62 namespace: antibiotic_resistance def: "CMY-62 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-62" EXACT CARD_Short_Name [] [Term] id: ARO:3002076 name: CMY-63 namespace: antibiotic_resistance def: "CMY-63 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-63" EXACT CARD_Short_Name [] [Term] id: ARO:3002077 name: CMY-64 namespace: antibiotic_resistance def: "CMY-64 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-64" EXACT CARD_Short_Name [] [Term] id: ARO:3002078 name: CMY-65 namespace: antibiotic_resistance def: "CMY-65 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-65" EXACT CARD_Short_Name [] [Term] id: ARO:3002079 name: CMY-66 namespace: antibiotic_resistance def: "CMY-66 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-66" EXACT CARD_Short_Name [] [Term] id: ARO:3002080 name: CMY-67 namespace: antibiotic_resistance def: "CMY-67 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-67" EXACT CARD_Short_Name [] [Term] id: ARO:3002081 name: CMY-68 namespace: antibiotic_resistance def: "CMY-68 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-68" EXACT CARD_Short_Name [] [Term] id: ARO:3002082 name: CMY-69 namespace: antibiotic_resistance def: "CMY-69 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-69" EXACT CARD_Short_Name [] [Term] id: ARO:3002083 name: CMY-70 namespace: antibiotic_resistance def: "CMY-70 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-70" EXACT CARD_Short_Name [] [Term] id: ARO:3002084 name: CMY-71 namespace: antibiotic_resistance def: "CMY-71 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-71" EXACT CARD_Short_Name [] [Term] id: ARO:3002085 name: CMY-72 namespace: antibiotic_resistance def: "CMY-72 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-72" EXACT CARD_Short_Name [] [Term] id: ARO:3002086 name: CMY-73 namespace: antibiotic_resistance def: "CMY-73 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-73" EXACT CARD_Short_Name [] [Term] id: ARO:3002087 name: CMY-74 namespace: antibiotic_resistance def: "CMY-74 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-74" EXACT CARD_Short_Name [] [Term] id: ARO:3002088 name: CMY-75 namespace: antibiotic_resistance def: "CMY-75 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-75" EXACT CARD_Short_Name [] [Term] id: ARO:3002089 name: CMY-76 namespace: antibiotic_resistance def: "CMY-76 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-76" EXACT CARD_Short_Name [] [Term] id: ARO:3002090 name: CMY-77 namespace: antibiotic_resistance def: "CMY-77 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-77" EXACT CARD_Short_Name [] [Term] id: ARO:3002091 name: CMY-78 namespace: antibiotic_resistance def: "CMY-78 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-78" EXACT CARD_Short_Name [] [Term] id: ARO:3002092 name: CMY-79 namespace: antibiotic_resistance def: "CMY-79 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-79" EXACT CARD_Short_Name [] [Term] id: ARO:3002093 name: CMY-80 namespace: antibiotic_resistance def: "CMY-80 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-80" EXACT CARD_Short_Name [] [Term] id: ARO:3002094 name: CMY-81 namespace: antibiotic_resistance def: "CMY-81 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-81" EXACT CARD_Short_Name [] [Term] id: ARO:3002095 name: CMY-82 namespace: antibiotic_resistance def: "CMY-82 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-82" EXACT CARD_Short_Name [] [Term] id: ARO:3002096 name: CMY-83 namespace: antibiotic_resistance def: "CMY-83 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-83" EXACT CARD_Short_Name [] [Term] id: ARO:3002097 name: CMY-84 namespace: antibiotic_resistance def: "CMY-84 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-84" EXACT CARD_Short_Name [] [Term] id: ARO:3002098 name: CMY-85 namespace: antibiotic_resistance def: "CMY-85 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-85" EXACT CARD_Short_Name [] [Term] id: ARO:3002099 name: CMY-86 namespace: antibiotic_resistance def: "CMY-86 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-86" EXACT CARD_Short_Name [] [Term] id: ARO:3002100 name: CMY-87 namespace: antibiotic_resistance def: "CMY-87 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-87" EXACT CARD_Short_Name [] [Term] id: ARO:3002101 name: CMY-88 namespace: antibiotic_resistance def: "CMY-88 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase [Term] id: ARO:3002102 name: CMY-89 namespace: antibiotic_resistance def: "CMY-89 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin." [PMID:24267783] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-89" EXACT CARD_Short_Name [] [Term] id: ARO:3002103 name: CMY-90 namespace: antibiotic_resistance def: "CMY-90 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-90" EXACT CARD_Short_Name [] [Term] id: ARO:3002104 name: CMY-91 namespace: antibiotic_resistance def: "CMY-91 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase [Term] id: ARO:3002105 name: CMY-92 namespace: antibiotic_resistance def: "CMY-92 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase [Term] id: ARO:3002106 name: CMY-93 namespace: antibiotic_resistance def: "CMY-93 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-93" EXACT CARD_Short_Name [] [Term] id: ARO:3002107 name: CMY-94 namespace: antibiotic_resistance def: "CMY-94 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-94" EXACT CARD_Short_Name [] [Term] id: ARO:3002108 name: CMY-95 namespace: antibiotic_resistance def: "CMY-95 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-95" EXACT CARD_Short_Name [] [Term] id: ARO:3002109 name: CMY-96 namespace: antibiotic_resistance def: "CMY-96 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-96" EXACT CARD_Short_Name [] [Term] id: ARO:3002110 name: CMY-97 namespace: antibiotic_resistance def: "CMY-97 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 25-OCT-2012." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-97" EXACT CARD_Short_Name [] [Term] id: ARO:3002111 name: CMY-98 namespace: antibiotic_resistance def: "CMY-98 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-98" EXACT CARD_Short_Name [] [Term] id: ARO:3002112 name: CMY-100 namespace: antibiotic_resistance def: "CMY-100 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-100" EXACT CARD_Short_Name [] [Term] id: ARO:3002113 name: CMY-101 namespace: antibiotic_resistance def: "CMY-101 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-101" EXACT CARD_Short_Name [] [Term] id: ARO:3002114 name: CMY-102 namespace: antibiotic_resistance def: "CMY-102 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-102" EXACT CARD_Short_Name [] [Term] id: ARO:3002115 name: CMY-103 namespace: antibiotic_resistance def: "CMY-103 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-103" EXACT CARD_Short_Name [] [Term] id: ARO:3002116 name: CMY-104 namespace: antibiotic_resistance def: "CMY-104 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-104" EXACT CARD_Short_Name [] [Term] id: ARO:3002117 name: CMY-105 namespace: antibiotic_resistance def: "CMY-105 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-105" EXACT CARD_Short_Name [] [Term] id: ARO:3002118 name: CMY-106 namespace: antibiotic_resistance def: "CMY-106 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-106" EXACT CARD_Short_Name [] [Term] id: ARO:3002119 name: CMY-107 namespace: antibiotic_resistance def: "CMY-107 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-107" EXACT CARD_Short_Name [] [Term] id: ARO:3002120 name: CMY-108 namespace: antibiotic_resistance def: "CMY-108 is a beta-lactamase present in plasmids of clinical Escherichia coli from humans and companion animals in the upper Midwestern USA . From the Lahey list of CMY beta-lactamases." [PMID:24500191] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-108" EXACT CARD_Short_Name [] [Term] id: ARO:3002121 name: CMY-109 namespace: antibiotic_resistance def: "CMY-109 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-109" EXACT CARD_Short_Name [] [Term] id: ARO:3002122 name: CMY-111 namespace: antibiotic_resistance def: "CMY-111 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-111" EXACT CARD_Short_Name [] [Term] id: ARO:3002123 name: CMY-112 namespace: antibiotic_resistance def: "CMY-112 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-112" EXACT CARD_Short_Name [] [Term] id: ARO:3002124 name: CMY-113 namespace: antibiotic_resistance def: "CMY-113 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-113" EXACT CARD_Short_Name [] [Term] id: ARO:3002125 name: CMY-114 namespace: antibiotic_resistance def: "CMY-114 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-114" EXACT CARD_Short_Name [] [Term] id: ARO:3002126 name: CMY-115 namespace: antibiotic_resistance def: "CMY-115 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-115" EXACT CARD_Short_Name [] [Term] id: ARO:3002127 name: CMY-116 namespace: antibiotic_resistance def: "CMY-116 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-116" EXACT CARD_Short_Name [] [Term] id: ARO:3002128 name: CMY-117 namespace: antibiotic_resistance def: "CMY-117 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-117" EXACT CARD_Short_Name [] [Term] id: ARO:3002129 name: CMY-118 namespace: antibiotic_resistance def: "CMY-118 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-118" EXACT CARD_Short_Name [] [Term] id: ARO:3002130 name: CMY-119 namespace: antibiotic_resistance def: "CMY-119 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-119" EXACT CARD_Short_Name [] [Term] id: ARO:3002131 name: CMY-120 namespace: antibiotic_resistance def: "CMY-120 is a beta-lactamase. From the Lahey list of CMY beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase [Term] id: ARO:3002132 name: DHA-1 namespace: antibiotic_resistance def: "DHA-1 is a class C beta-lactamase found in Morganella morganii and Salmonella enterica." [PMID:9736562] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002133 name: DHA-2 namespace: antibiotic_resistance def: "DHA-2 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:11157909] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002134 name: DHA-3 namespace: antibiotic_resistance def: "DHA-3 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16216104] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002135 name: DHA-6 namespace: antibiotic_resistance def: "DHA-6 is a beta-lactamase found in the Enterobacteriaceae family." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002136 name: DHA-7 namespace: antibiotic_resistance def: "DHA-7 is a beta-lactamase found in the Enterobacteriaceae family." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002137 name: DHA-4 namespace: antibiotic_resistance def: "DHA-4 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002138 name: DHA-5 namespace: antibiotic_resistance def: "DHA-5 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002139 name: DHA-8 namespace: antibiotic_resistance def: "DHA-8 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase [Term] id: ARO:3002140 name: DHA-9 namespace: antibiotic_resistance def: "DHA-9 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002141 name: DHA-10 namespace: antibiotic_resistance def: "DHA-10 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002142 name: DHA-11 namespace: antibiotic_resistance def: "DHA-11 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase [Term] id: ARO:3002143 name: DHA-12 namespace: antibiotic_resistance def: "DHA-12 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002144 name: DHA-13 namespace: antibiotic_resistance def: "DHA-13 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002145 name: DHA-14 namespace: antibiotic_resistance def: "DHA-14 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002146 name: DHA-15 namespace: antibiotic_resistance def: "DHA-15 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002147 name: DHA-16 namespace: antibiotic_resistance def: "DHA-16 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002148 name: DHA-17 namespace: antibiotic_resistance def: "DHA-17 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002149 name: DHA-18 namespace: antibiotic_resistance def: "DHA-18 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002150 name: DHA-19 namespace: antibiotic_resistance def: "DHA-19 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002151 name: DHA-20 namespace: antibiotic_resistance def: "DHA-20 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-20" EXACT CARD_Short_Name [] [Term] id: ARO:3002152 name: DHA-21 namespace: antibiotic_resistance def: "DHA-21 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-21" EXACT CARD_Short_Name [] [Term] id: ARO:3002153 name: DHA-22 namespace: antibiotic_resistance def: "DHA-22 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-22" EXACT CARD_Short_Name [] [Term] id: ARO:3002154 name: DHA-23 namespace: antibiotic_resistance def: "DHA-23 is a beta-lactamase. From the Lahey list of DHA beta-lactamases." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-23" EXACT CARD_Short_Name [] [Term] id: ARO:3002155 name: FOX-1 namespace: antibiotic_resistance def: "FOX-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:7811034] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002156 name: FOX-2 namespace: antibiotic_resistance def: "FOX-2 is a beta-lactamase found in Escherichia coli." [PMID:9303413] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002157 name: FOX-3 namespace: antibiotic_resistance def: "FOX-3 is a beta-lactamase found in Klebsiella oxytoca." [PMID:9527810] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002158 name: FOX-4 namespace: antibiotic_resistance def: "FOX-4 is a beta-lactamase found in Escherichia coli." [PMID:10952615] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002159 name: FOX-5 namespace: antibiotic_resistance def: "FOX-5 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:11600376] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-5" EXACT CARD_Short_Name [] synonym: "FOX-6" EXACT [] [Term] id: ARO:3002160 name: FOX-7 namespace: antibiotic_resistance def: "FOX-7 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:24088849] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002161 name: FOX-8 namespace: antibiotic_resistance def: "FOX-8 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:22956023] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002162 name: FOX-10 namespace: antibiotic_resistance def: "FOX-10 is a beta-lactamase. From the Lahey list of FOX beta-lactamases." [] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002163 name: FOX-9 namespace: antibiotic_resistance def: "FOX-9 is a beta-lactamase. From the Lahey list of FOX beta-lactamases." [] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002164 name: FOX-11 namespace: antibiotic_resistance def: "FOX-11 is a beta-lactamase. From the Lahey list of FOX beta-lactamases." [] is_a: ARO:3000067 ! FOX beta-lactamase [Term] id: ARO:3002165 name: FOX-12 namespace: antibiotic_resistance def: "FOX-12 is a beta-lactamase. From the Lahey list of FOX beta-lactamases." [] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002166 name: MIR-1 namespace: antibiotic_resistance def: "MIR-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:1963529] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002167 name: MIR-4 namespace: antibiotic_resistance def: "MIR-4 is a beta-lactamase found in Escherichia coli." [PMID:18781358] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002168 name: MIR-2 namespace: antibiotic_resistance def: "MIR-2 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002169 name: MIR-3 namespace: antibiotic_resistance def: "MIR-3 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002170 name: MIR-5 namespace: antibiotic_resistance def: "MIR-5 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-5" EXACT CARD_Short_Name [] synonym: "MIR-8" EXACT [] [Term] id: ARO:3002171 name: MIR-6 namespace: antibiotic_resistance def: "MIR-6 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002172 name: MIR-7 namespace: antibiotic_resistance def: "MIR-7 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002174 name: MIR-9 namespace: antibiotic_resistance def: "MIR-9 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002175 name: MIR-10 namespace: antibiotic_resistance def: "MIR-10 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002176 name: MIR-11 namespace: antibiotic_resistance def: "MIR-11 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002177 name: MIR-12 namespace: antibiotic_resistance def: "MIR-12 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002178 name: MIR-13 namespace: antibiotic_resistance def: "MIR-13 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002179 name: MIR-14 namespace: antibiotic_resistance def: "MIR-14 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002180 name: MIR-15 namespace: antibiotic_resistance def: "MIR-15 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002181 name: MIR-16 namespace: antibiotic_resistance def: "MIR-16 is a beta-lactamase. From the Lahey list of MIR beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002182 name: MOX-1 namespace: antibiotic_resistance def: "MOX-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:8112596] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002183 name: MOX-2 namespace: antibiotic_resistance def: "MOX-2 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:12069985] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002184 name: MOX-4 namespace: antibiotic_resistance def: "MOX-4 is a beta-lactamase found in Aeromonas caviae." [PMID:20339022] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002185 name: MOX-6 namespace: antibiotic_resistance def: "MOX-6 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:21968366] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002186 name: MOX-3 namespace: antibiotic_resistance def: "MOX-3 is a beta-lactamase. From the Lahey list of MOX beta-lactamases." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002188 name: MOX-5 namespace: antibiotic_resistance def: "MOX-5 is a beta-lactamase. From the Lahey list of MOX beta-lactamases." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002189 name: MOX-7 namespace: antibiotic_resistance def: "MOX-7 is a beta-lactamase. From the Lahey list of MOX beta-lactamases." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002190 name: MOX-8 namespace: antibiotic_resistance def: "MOX-8 is a beta-lactamase. From the Lahey list of MOX beta-lactamases." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002191 name: MOX-9 namespace: antibiotic_resistance def: "MOX-9 is a beta-lactamase found in Citrobacter freundii." [PMID:26126492] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002192 name: IMP-1 namespace: antibiotic_resistance def: "IMP-1 is a beta-lactamase found in Serratia marcescens." [PMID:8141584] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002193 name: IMP-2 namespace: antibiotic_resistance def: "IMP-2 is a beta-lactamase found in Acinetobacter baumannii." [PMID:10770756] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002194 name: IMP-3 namespace: antibiotic_resistance def: "IMP-3 is a beta-lactamase found in Acinetobacter baumannii." [PMID:10898670] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-3" EXACT CARD_Short_Name [] synonym: "met-1" EXACT [] [Term] id: ARO:3002195 name: IMP-4 namespace: antibiotic_resistance def: "IMP-4 is a beta-lactamase found in Acinetobacter baumannii." [PMID:17284537] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002196 name: IMP-5 namespace: antibiotic_resistance def: "IMP-5 is a beta-lactamase found in Acinetobacter baumannii." [PMID:12393197] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002197 name: IMP-6 namespace: antibiotic_resistance def: "IMP-6 is a beta-lactamase found in Serratia marcescens." [PMID:11302793] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002198 name: IMP-7 namespace: antibiotic_resistance def: "IMP-7 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:11751148] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002199 name: IMP-8 namespace: antibiotic_resistance def: "IMP-8 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:11451699] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-47" EXACT [] synonym: "IMP-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002200 name: IMP-9 namespace: antibiotic_resistance def: "IMP-9 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:16377710] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002201 name: IMP-10 namespace: antibiotic_resistance def: "IMP-10 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:12019129] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002202 name: IMP-11 namespace: antibiotic_resistance def: "IMP-11 is a beta-lactamase found in Pseudomonas and Acinetobacter spp." [PMID:21707466] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002203 name: IMP-12 namespace: antibiotic_resistance def: "IMP-12 is a beta-lactamase found in Pseudomonas putida." [PMID:12709317] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002204 name: IMP-13 namespace: antibiotic_resistance def: "IMP-13 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:12951335] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002205 name: IMP-14 namespace: antibiotic_resistance def: "IMP-14 is a beta-lactamase found in Pseudomonas and Acinetobacter spp." [PMID:21707466] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002206 name: IMP-15 namespace: antibiotic_resistance def: "IMP-15 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:18362195] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002207 name: IMP-16 namespace: antibiotic_resistance def: "IMP-16 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:15561846] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002208 name: IMP-17 namespace: antibiotic_resistance def: "IMP-17 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002209 name: IMP-18 namespace: antibiotic_resistance def: "IMP-18 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:16723605] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002210 name: IMP-19 namespace: antibiotic_resistance def: "IMP-19 is a beta-lactamase found in Aeromonas caviae." [PMID:7938180] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002211 name: IMP-20 namespace: antibiotic_resistance def: "IMP-20 is a beta-lactamase found in Pseudomonas and Acinetobacter spp." [PMID:21707466] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-20" EXACT CARD_Short_Name [] [Term] id: ARO:3002212 name: IMP-21 namespace: antibiotic_resistance def: "IMP-21 is a beta-lactamase found in Pseudomonas and Acinetobacter spp." [PMID:21707466] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-21" EXACT CARD_Short_Name [] [Term] id: ARO:3002213 name: IMP-22 namespace: antibiotic_resistance def: "IMP-22 is a beta-lactamase found in Pseudomonas spp." [PMID:19270313] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-22" EXACT CARD_Short_Name [] [Term] id: ARO:3002214 name: IMP-23 namespace: antibiotic_resistance def: "IMP-23 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-23" EXACT CARD_Short_Name [] [Term] id: ARO:3002215 name: IMP-24 namespace: antibiotic_resistance def: "IMP-24 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:18804966] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-24" EXACT CARD_Short_Name [] [Term] id: ARO:3002216 name: IMP-25 namespace: antibiotic_resistance def: "IMP-25 is a beta-lactamase found in Serratia marcescens." [PMID:23006757] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-25" EXACT CARD_Short_Name [] [Term] id: ARO:3002217 name: IMP-26 namespace: antibiotic_resistance def: "IMP-26 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:20463166] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-26" EXACT CARD_Short_Name [] [Term] id: ARO:3002218 name: IMP-27 namespace: antibiotic_resistance def: "IMP-27 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-27" EXACT CARD_Short_Name [] [Term] id: ARO:3002219 name: IMP-28 namespace: antibiotic_resistance def: "IMP-28 is a beta-lactamase found in Klebsiella oxytoca." [PMID:22668859] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-28" EXACT CARD_Short_Name [] [Term] id: ARO:3002220 name: IMP-29 namespace: antibiotic_resistance def: "IMP-29 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:22290960] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-29" EXACT CARD_Short_Name [] [Term] id: ARO:3002221 name: IMP-30 namespace: antibiotic_resistance def: "IMP-30 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:23836186] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-30" EXACT CARD_Short_Name [] [Term] id: ARO:3002222 name: IMP-31 namespace: antibiotic_resistance def: "IMP-31 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-31" EXACT CARD_Short_Name [] [Term] id: ARO:3002223 name: IMP-32 namespace: antibiotic_resistance def: "IMP-32 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-32" EXACT CARD_Short_Name [] [Term] id: ARO:3002224 name: IMP-33 namespace: antibiotic_resistance def: "IMP-33 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:24041889] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-33" EXACT CARD_Short_Name [] [Term] id: ARO:3002225 name: IMP-34 namespace: antibiotic_resistance def: "IMP-34 is a beta-lactamase found in Klebsiella spp." [PMID:23541689] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-34" EXACT CARD_Short_Name [] [Term] id: ARO:3002226 name: IMP-35 namespace: antibiotic_resistance def: "IMP-35 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:23341129] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-35" EXACT CARD_Short_Name [] [Term] id: ARO:3002227 name: IMP-36 namespace: antibiotic_resistance def: "IMP-36 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase [Term] id: ARO:3002228 name: IMP-37 namespace: antibiotic_resistance def: "IMP-37 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-37" EXACT CARD_Short_Name [] [Term] id: ARO:3002229 name: IMP-38 namespace: antibiotic_resistance def: "IMP-38 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-38" EXACT CARD_Short_Name [] [Term] id: ARO:3002230 name: IMP-39 namespace: antibiotic_resistance def: "IMP-39 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-39" EXACT CARD_Short_Name [] [Term] id: ARO:3002231 name: IMP-40 namespace: antibiotic_resistance def: "IMP-40 is a beta-lactamase found in Pseudomonas and Acinetobacter spp." [PMID:23536409] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-40" EXACT CARD_Short_Name [] [Term] id: ARO:3002232 name: IMP-41 namespace: antibiotic_resistance def: "IMP-41 is a beta-lactamase found in Pseudomonas and Acinetobacter spp." [PMID:23536409] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-41" EXACT CARD_Short_Name [] [Term] id: ARO:3002233 name: IMP-42 namespace: antibiotic_resistance def: "IMP-42 is a beta-lactamase found in Pseudomonas and Acinetobacter spp." [PMID:23536409] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-42" EXACT CARD_Short_Name [] [Term] id: ARO:3002234 name: IMP-43 namespace: antibiotic_resistance def: "IMP-43 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:23836174] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-43" EXACT CARD_Short_Name [] [Term] id: ARO:3002235 name: IMP-44 namespace: antibiotic_resistance def: "IMP-44 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:23836174] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-44" EXACT CARD_Short_Name [] [Term] id: ARO:3002236 name: IMP-45 namespace: antibiotic_resistance def: "IMP-45 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:24777897] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-45" EXACT CARD_Short_Name [] [Term] id: ARO:3002237 name: IMP-46 namespace: antibiotic_resistance def: "IMP-46 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-46" EXACT CARD_Short_Name [] [Term] id: ARO:3002239 name: IMP-48 namespace: antibiotic_resistance def: "IMP-48 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-48" EXACT CARD_Short_Name [] [Term] id: ARO:3002240 name: CARB-1 namespace: antibiotic_resistance def: "CARB-1 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:11959558] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-1" EXACT CARD_Short_Name [] synonym: "PSE-4, BlaP1a" EXACT [] [Term] id: ARO:3002241 name: CARB-2 namespace: antibiotic_resistance def: "CARB-2 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:1804019] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-2" EXACT CARD_Short_Name [] synonym: "PSE-1, BlaP1b, PSE-3" EXACT [] [Term] id: ARO:3002242 name: CARB-3 namespace: antibiotic_resistance def: "CARB-3 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:1650733] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002243 name: CARB-4 namespace: antibiotic_resistance def: "CARB-4 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:9687391] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "BlaP3" EXACT [] synonym: "CARB-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002244 name: CARB-5 namespace: antibiotic_resistance def: "CARB-5 is a beta-lactamase found in Acinetobacter calcoaceticus." [PMID:10722515] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "BlaRTG-2" EXACT [] synonym: "CARB-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002245 name: CARB-6 namespace: antibiotic_resistance def: "CARB-6 is a beta-lactamase found in Vibrio cholerae." [PMID:9925522] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002246 name: CARB-7 namespace: antibiotic_resistance def: "CARB-7 is a beta-lactamase found in Vibrio cholerae." [PMID:12069969] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-11, PSE-5" EXACT [] synonym: "CARB-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002247 name: CARB-8 namespace: antibiotic_resistance def: "CARB-8 is a beta-lactamase found in Oligella urethralis." [PMID:12709319] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "BlaRTG-3" EXACT [] synonym: "CARB-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002248 name: CARB-9 namespace: antibiotic_resistance def: "CARB-9 is a beta-lactamase found in Vibrio cholerae." [PMID:15388476] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002249 name: CARB-10 namespace: antibiotic_resistance def: "CARB-10 is a beta-lactamase found in Acinetobacter baumannii." [PMID:19380596] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "BlaRTG-4" EXACT [] synonym: "CARB-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002250 name: CARB-12 namespace: antibiotic_resistance def: "CARB-12 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002251 name: CARB-13 namespace: antibiotic_resistance def: "CARB-13 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase [Term] id: ARO:3002252 name: CARB-14 namespace: antibiotic_resistance def: "CARB-14 is a beta-lactamase found in Acinetobacter baumannii." [PMID:22633451] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "BlaRTG-5" EXACT [] synonym: "CARB-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002253 name: CARB-15 namespace: antibiotic_resistance def: "CARB-15 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase [Term] id: ARO:3002254 name: CARB-17 namespace: antibiotic_resistance def: "CARB-17 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002255 name: CARB-16 namespace: antibiotic_resistance def: "CARB-16 is a beta-lactamase. From the Lahey list of IMP beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "BlaRTG-6" EXACT [] synonym: "CARB-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002256 name: IND-1 namespace: antibiotic_resistance def: "IND-1 is a beta-lactamase found in Chryseobacterium indologenes." [PMID:10077836] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002257 name: IND-2 namespace: antibiotic_resistance def: "IND-2 is a beta-lactamase found in Chryseobacterium indologenes." [PMID:11036018] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002258 name: IND-2a namespace: antibiotic_resistance def: "IND-2a is a beta-lactamase found in Chryseobacterium indologenes." [PMID:11036018] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-13" EXACT [] synonym: "IND-2a" EXACT CARD_Short_Name [] [Term] id: ARO:3002259 name: IND-3 namespace: antibiotic_resistance def: "IND-3 is a beta-lactamase found in Chryseobacterium indologenes." [PMID:11036018] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002260 name: IND-4 namespace: antibiotic_resistance def: "IND-4 is a beta-lactamase found in Chryseobacterium indologenes." [PMID:11036018] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002261 name: IND-5 namespace: antibiotic_resistance def: "IND-5 is a beta-lactamase found in Chryseobacterium indologenes." [PMID:17470648] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002262 name: IND-6 namespace: antibiotic_resistance def: "IND-6 is a beta-lactamase found in Chryseobacterium indologenes." [PMID:19651915] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002263 name: IND-7 namespace: antibiotic_resistance def: "IND-7 is a beta-lactamase found in Chryseobacterium indologenes." [PMID:20305272] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002264 name: IND-8 namespace: antibiotic_resistance def: "IND-8 is a beta-lactamase found in Escherichia coli." [PMID:3876328] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002265 name: IND-9 namespace: antibiotic_resistance def: "IND-9 is a beta-lactamase found in Escherichia coli." [PMID:3876328] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002266 name: IND-10 namespace: antibiotic_resistance def: "IND-10 is a beta-lactamase found in Escherichia coli." [PMID:3876328] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002267 name: IND-11 namespace: antibiotic_resistance def: "IND-11 is a beta-lactamase found in Escherichia coli." [PMID:3876328] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002268 name: IND-12 namespace: antibiotic_resistance def: "IND-12 is a beta-lactamase found in Escherichia coli." [PMID:3876328] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002269 name: IND-14 namespace: antibiotic_resistance def: "IND-14 is a beta-lactamase found in Escherichia coli." [PMID:3876328] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002270 name: IND-15 namespace: antibiotic_resistance def: "IND-15 is a beta-lactamase found in Escherichia coli." [PMID:3876328] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002271 name: VIM-1 namespace: antibiotic_resistance def: "VIM-1 is a beta-lactamase found in Pseudomonas spp." [PMID:18804966] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002272 name: VIM-2 namespace: antibiotic_resistance def: "VIM-2 is a beta-lactamase found in Pseudomonas spp." [PMID:18804966] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-2" EXACT CARD_Short_Name [] xref: PDB:1KO2 [Term] id: ARO:3002273 name: VIM-3 namespace: antibiotic_resistance def: "VIM-3 is a beta-lactamase found in Pseudomonas spp." [PMID:11451678] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002274 name: VIM-4 namespace: antibiotic_resistance def: "VIM-4 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:12435718] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002275 name: VIM-5 namespace: antibiotic_resistance def: "VIM-5 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:15190017] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002276 name: VIM-6 namespace: antibiotic_resistance def: "VIM-6 is a beta-lactamase found in Pseudomonas spp." [PMID:15155248] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002277 name: VIM-7 namespace: antibiotic_resistance def: "VIM-7 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:14693560] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002278 name: VIM-8 namespace: antibiotic_resistance def: "VIM-8 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:15528701] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002279 name: VIM-9 namespace: antibiotic_resistance def: "VIM-9 is a beta-lactamase found in Pseudomonas spp." [PMID:18819973] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002280 name: VIM-10 namespace: antibiotic_resistance def: "VIM-10 is a beta-lactamase found in Pseudomonas spp." [PMID:18819973] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002281 name: VIM-11 namespace: antibiotic_resistance def: "VIM-11 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:15616342] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002282 name: VIM-12 namespace: antibiotic_resistance def: "VIM-12 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304191] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002283 name: VIM-13 namespace: antibiotic_resistance def: "VIM-13 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:18644957] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002284 name: VIM-14 namespace: antibiotic_resistance def: "VIM-14 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:21521413] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002285 name: VIM-15 namespace: antibiotic_resistance def: "VIM-15 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:18519714] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002286 name: VIM-16 namespace: antibiotic_resistance def: "VIM-16 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:18519714] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002287 name: VIM-17 namespace: antibiotic_resistance def: "VIM-17 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:19164147] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002288 name: VIM-18 namespace: antibiotic_resistance def: "VIM-18 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:19114677] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002289 name: VIM-19 namespace: antibiotic_resistance def: "VIM-19 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:19917750] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002290 name: VIM-20 namespace: antibiotic_resistance def: "VIM-20 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-20" EXACT CARD_Short_Name [] [Term] id: ARO:3002291 name: VIM-21 namespace: antibiotic_resistance def: "VIM-21 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase [Term] id: ARO:3002292 name: VIM-22 namespace: antibiotic_resistance def: "VIM-22 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase [Term] id: ARO:3002293 name: VIM-23 namespace: antibiotic_resistance def: "VIM-23 is a beta-lactamase found in Enterobacter cloacae." [PMID:20961909] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-23" EXACT CARD_Short_Name [] [Term] id: ARO:3002294 name: VIM-24 namespace: antibiotic_resistance def: "VIM-24 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:21282438] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-24" EXACT CARD_Short_Name [] [Term] id: ARO:3002295 name: VIM-25 namespace: antibiotic_resistance def: "VIM-25 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-25" EXACT CARD_Short_Name [] [Term] id: ARO:3002296 name: VIM-26 namespace: antibiotic_resistance def: "VIM-26 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-26" EXACT CARD_Short_Name [] [Term] id: ARO:3002297 name: VIM-27 namespace: antibiotic_resistance def: "VIM-27 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:21518835] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-27" EXACT CARD_Short_Name [] [Term] id: ARO:3002298 name: VIM-28 namespace: antibiotic_resistance def: "VIM-28 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-28" EXACT CARD_Short_Name [] [Term] id: ARO:3002299 name: VIM-29 namespace: antibiotic_resistance def: "VIM-29 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:23954421] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-29" EXACT CARD_Short_Name [] [Term] id: ARO:3002300 name: VIM-30 namespace: antibiotic_resistance def: "VIM-30 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:23658259] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-30" EXACT CARD_Short_Name [] [Term] id: ARO:3002301 name: VIM-31 namespace: antibiotic_resistance def: "VIM-31 is a beta-lactamase found in Enterobacter cloacae." [PMID:22391550] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-31" EXACT CARD_Short_Name [] [Term] id: ARO:3002302 name: VIM-32 namespace: antibiotic_resistance def: "VIM-32 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-32" EXACT CARD_Short_Name [] [Term] id: ARO:3002303 name: VIM-33 namespace: antibiotic_resistance def: "VIM-33 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:23070171] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-33" EXACT CARD_Short_Name [] [Term] id: ARO:3002304 name: VIM-34 namespace: antibiotic_resistance def: "VIM-34 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:23934739] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-34" EXACT CARD_Short_Name [] [Term] id: ARO:3002305 name: VIM-35 namespace: antibiotic_resistance def: "VIM-35 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-35" EXACT CARD_Short_Name [] [Term] id: ARO:3002306 name: VIM-36 namespace: antibiotic_resistance def: "VIM-36 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:24603963] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-36" EXACT CARD_Short_Name [] [Term] id: ARO:3002307 name: VIM-37 namespace: antibiotic_resistance def: "VIM-37 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:24603963] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-37" EXACT CARD_Short_Name [] [Term] id: ARO:3002308 name: VIM-38 namespace: antibiotic_resistance def: "VIM-38 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:24428980] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-38" EXACT CARD_Short_Name [] [Term] id: ARO:3002309 name: VIM-39 namespace: antibiotic_resistance def: "VIM-39 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-39" EXACT CARD_Short_Name [] [Term] id: ARO:3002310 name: VIM-40 namespace: antibiotic_resistance def: "VIM-40 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-40" EXACT CARD_Short_Name [] [Term] id: ARO:3002311 name: VIM-41 namespace: antibiotic_resistance def: "VIM-41 is a beta-lactamase. From the Lahey list of VIM beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-41" EXACT CARD_Short_Name [] [Term] id: ARO:3002312 name: KPC-2 namespace: antibiotic_resistance def: "KPC-2 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa." [PMID:17261621, PMID:12615876] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-1" EXACT [] synonym: "KPC-2" EXACT CARD_Short_Name [] xref: PDB:2OV5 [Term] id: ARO:3002313 name: KPC-3 namespace: antibiotic_resistance def: "KPC-3 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19015357] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002314 name: KPC-4 namespace: antibiotic_resistance def: "KPC-4 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19015357] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002315 name: KPC-5 namespace: antibiotic_resistance def: "KPC-5 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa." [PMID:19015357] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002316 name: KPC-6 namespace: antibiotic_resistance def: "KPC-6 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:22908150] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002317 name: KPC-7 namespace: antibiotic_resistance def: "KPC-7 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19036932] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002318 name: KPC-8 namespace: antibiotic_resistance def: "KPC-8 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:20334553] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002319 name: KPC-9 namespace: antibiotic_resistance def: "KPC-9 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:22964247] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002320 name: KPC-10 namespace: antibiotic_resistance def: "KPC-10 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:20038618] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002321 name: KPC-11 namespace: antibiotic_resistance def: "KPC-11 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:22322349] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002322 name: KPC-12 namespace: antibiotic_resistance def: "KPC-12 is a beta-lactamase. From the Lahey list of KPC beta-lactamases." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002323 name: KPC-13 namespace: antibiotic_resistance def: "KPC-13 is a beta-lactamase. From the Lahey list of KPC beta-lactamases." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002324 name: KPC-14 namespace: antibiotic_resistance def: "KPC-14 is a beta-lactamase. From the Lahey list of KPC beta-lactamases." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002325 name: KPC-15 namespace: antibiotic_resistance def: "KPC-15 is a beta-lactamase. From the Lahey list of KPC beta-lactamases." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002326 name: KPC-16 namespace: antibiotic_resistance def: "KPC-16 is a beta-lactamase. From the Lahey list of KPC beta-lactamases." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002327 name: KPC-17 namespace: antibiotic_resistance def: "KPC-17 is a beta-lactamase. From the Lahey list of KPC beta-lactamases." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002328 name: KPC-18 namespace: antibiotic_resistance def: "KPC-18 is a beta-lactamase. From the Lahey list of KPC beta-lactamases." [PMID:26719440] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002329 name: KPC-19 namespace: antibiotic_resistance def: "KPC-19 is a beta-lactamase. From the Lahey list of KPC beta-lactamases." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002330 name: GES-1 namespace: antibiotic_resistance def: "GES-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:10681329] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002331 name: GES-2 namespace: antibiotic_resistance def: "GES-2 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:11502535] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002332 name: GES-3 namespace: antibiotic_resistance def: "GES-3 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15155185] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002333 name: GES-4 namespace: antibiotic_resistance def: "GES-4 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15273099] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002334 name: GES-5 namespace: antibiotic_resistance def: "GES-5 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:15135524] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002335 name: GES-6 namespace: antibiotic_resistance def: "GES-6 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:15135524] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002336 name: GES-7 namespace: antibiotic_resistance def: "GES-7 is a beta-lactamase found in Enterobacter cloacae." [PMID:10952563] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-7" EXACT CARD_Short_Name [] synonym: "IBC-1" EXACT [] [Term] id: ARO:3002337 name: GES-8 namespace: antibiotic_resistance def: "GES-8 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:11679551] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-8" EXACT CARD_Short_Name [] synonym: "IBC-2" EXACT [] [Term] id: ARO:3002338 name: GES-9 namespace: antibiotic_resistance def: "GES-9 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:16048994] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002339 name: GES-10 namespace: antibiotic_resistance def: "GES-10 is a beta-lactamase. From the Lahey list of GES beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002340 name: GES-11 namespace: antibiotic_resistance def: "GES-11 is a beta-lactamase found in Acinetobacter baumannii." [PMID:19451292] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002341 name: GES-12 namespace: antibiotic_resistance def: "GES-12 is a beta-lactamase found in Acinetobacter baumannii." [PMID:20805394] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002342 name: GES-13 namespace: antibiotic_resistance def: "GES-13 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:20065056] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002343 name: GES-14 namespace: antibiotic_resistance def: "GES-14 is a beta-lactamase found in Acinetobacter baumannii." [PMID:20805394] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002344 name: GES-15 namespace: antibiotic_resistance def: "GES-15 is a beta-lactamase. From the Lahey list of GES beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002345 name: GES-16 namespace: antibiotic_resistance def: "GES-16 is a beta-lactamase. From the Lahey list of GES beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002346 name: GES-17 namespace: antibiotic_resistance def: "GES-17 is a beta-lactamase. From the Lahey list of GES beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002347 name: GES-18 namespace: antibiotic_resistance def: "GES-18 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:23114760] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002348 name: GES-19 namespace: antibiotic_resistance def: "GES-19 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:22526300] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002349 name: GES-20 namespace: antibiotic_resistance def: "GES-20 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:22526300] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-20" EXACT CARD_Short_Name [] [Term] id: ARO:3002350 name: GES-21 namespace: antibiotic_resistance def: "GES-21 is a beta-lactamase. From the Lahey list of GES beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-21" EXACT CARD_Short_Name [] [Term] id: ARO:3002351 name: GES-22 namespace: antibiotic_resistance def: "GES-22 is a beta-lactamase. From the Lahey list of GES beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-22" EXACT CARD_Short_Name [] [Term] id: ARO:3002352 name: GES-23 namespace: antibiotic_resistance def: "GES-23 is a beta-lactamase. From the Lahey list of GES beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-23" EXACT CARD_Short_Name [] [Term] id: ARO:3002353 name: GES-24 namespace: antibiotic_resistance def: "GES-24 is a beta-lactamase. From the Lahey list of GES beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-24" EXACT CARD_Short_Name [] [Term] id: ARO:3002354 name: NDM-3 namespace: antibiotic_resistance def: "NDM-3 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:23330550] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002355 name: NDM-4 namespace: antibiotic_resistance def: "NDM-4 is a beta-lactamase found in Escherichia coli." [PMID:22252797] is_a: ARO:3000057 ! NDM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "NDM-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002356 name: NDM-6 namespace: antibiotic_resistance def: "NDM-6 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:22526013] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002357 name: NDM-7 namespace: antibiotic_resistance def: "NDM-7 is a beta-lactamase found in Escherichia coli." [PMID:23557929] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002358 name: NDM-8 namespace: antibiotic_resistance def: "NDM-8 is a beta-lactamase found in Escherichia coli." [PMID:23459485] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002359 name: NDM-9 namespace: antibiotic_resistance def: "NDM-9 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:24913967] is_a: ARO:3000057 ! NDM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3007148 ! cefepime-taniborbactam synonym: "NDM-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002360 name: NDM-10 namespace: antibiotic_resistance def: "NDM-10 is a beta-lactamase. From the Lahey list of NDM beta-lactamases." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002361 name: NDM-11 namespace: antibiotic_resistance def: "NDM-11 is a beta-lactamase. From the Lahey list of NDM beta-lactamases." [PMID:29656053] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002362 name: NDM-12 namespace: antibiotic_resistance def: "NDM-12 is a beta-lactamase found in Escherichia coli." [PMID:25092693] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002363 name: PER-1 namespace: antibiotic_resistance def: "PER-1 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:8141562] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002364 name: PER-2 namespace: antibiotic_resistance def: "PER-2 is a beta-lactamase found in Salmonella typhimurium." [PMID:8851581] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002365 name: PER-3 namespace: antibiotic_resistance def: "PER-3 is a beta-lactamase found in Aeromonas spp." [PMID:21968366] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002366 name: PER-4 namespace: antibiotic_resistance def: "PER-4 is a beta-lactamase. From the Lahey list of PER beta-lactamases." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002367 name: PER-5 namespace: antibiotic_resistance def: "PER-5 is a beta-lactamase found in the Enterobacteriaceae family." [PMID:23284886] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002368 name: PER-6 namespace: antibiotic_resistance def: "PER-6 is a beta-lactamase found in Aeromonas allosaccharophila." [PMID:20145085] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002369 name: PER-7 namespace: antibiotic_resistance def: "PER-7 is a beta-lactamase found in Acinetobacter baumannii." [PMID:21383087] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002370 name: VEB-1 namespace: antibiotic_resistance def: "VEB-1 is a beta-lactamase found in Escherichia coli and Pseudomonas aeruginosa." [PMID:10427724, PMID:10049269] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002371 name: VEB-2 namespace: antibiotic_resistance def: "VEB-2 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:11807680] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002372 name: VEB-3 namespace: antibiotic_resistance def: "VEB-3 is a beta-lactamase found in Enterobacter cloacae." [PMID:15695687] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002373 name: VEB-4 namespace: antibiotic_resistance def: "VEB-4 is a beta-lactamase found in Proteus mirabilis." [PMID:18292096] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002374 name: VEB-6 namespace: antibiotic_resistance def: "VEB-6 is a beta-lactamase found in Proteus mirabilis." [PMID:18025117] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002375 name: VEB-5 namespace: antibiotic_resistance def: "VEB-5 is a beta-lactamase. From the Lahey list of VEB beta-lactamases." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002376 name: VEB-7 namespace: antibiotic_resistance def: "VEB-7 is a beta-lactamase. From the Lahey list of VEB beta-lactamases." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002377 name: VEB-8 namespace: antibiotic_resistance def: "VEB-8 is a beta-lactamase. From the Lahey list of VEB beta-lactamases." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002378 name: VEB-9 namespace: antibiotic_resistance def: "VEB-9 is a beta-lactamase. From the Lahey list of VEB beta-lactamases." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-1a" EXACT [] synonym: "VEB-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002379 name: SME-1 namespace: antibiotic_resistance def: "SME-1 is a beta-lactamase found in Serratia marcescens." [PMID:8092824] is_a: ARO:3000055 ! SME beta-lactamase synonym: "SME-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002380 name: SME-2 namespace: antibiotic_resistance def: "SME-2 is a beta-lactamase found in Serratia marcescens." [PMID:11036019] is_a: ARO:3000055 ! SME beta-lactamase synonym: "SME-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002381 name: SME-3 namespace: antibiotic_resistance def: "SME-3 is a beta-lactamase found in Serratia marcescens." [PMID:17005839] is_a: ARO:3000055 ! SME beta-lactamase synonym: "SME-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002382 name: SME-4 namespace: antibiotic_resistance def: "SME-4 is a beta-lactamase. From the Lahey list of SME beta-lactamases." [] is_a: ARO:3000055 ! SME beta-lactamase synonym: "SME-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002383 name: SME-5 namespace: antibiotic_resistance def: "SME-5 is a beta-lactamase. From the Lahey list of SME beta-lactamases." [] is_a: ARO:3000055 ! SME beta-lactamase synonym: "SME-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002384 name: BEL beta-lactamase namespace: antibiotic_resistance def: "BEL beta-lactamases are class A expanded-spectrum beta-lactamases that are inhibited by clavulanic acid. They are chromosomally encoded and hydrolyze most cephalosporins and aztreonam." [PMID:16127048] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3002385 name: BEL-1 namespace: antibiotic_resistance def: "BEL-1 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:16127048] is_a: ARO:3002384 ! BEL beta-lactamase synonym: "BEL-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002386 name: BEL-2 namespace: antibiotic_resistance def: "BEL-2 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:19884378] is_a: ARO:3002384 ! BEL beta-lactamase synonym: "BEL-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002387 name: BEL-3 namespace: antibiotic_resistance def: "BEL-3 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:19933793] is_a: ARO:3002384 ! BEL beta-lactamase synonym: "BEL-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002388 name: OXY beta-lactamase namespace: antibiotic_resistance def: "OXY beta-lactamases are chromosomal class A beta-lactamases that are found in Klebsiella oxytoca. At constitutive low levels, OXY beta-lactamases confer resistance to aminopenicillins and carboxypenicillins. At high induced levels, OXY beta-lactamases confer resistance to penicillins, cephalosporins and aztreonam." [PMID:23090395] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam synonym: "K1" EXACT [] synonym: "KOXY" EXACT [] [Term] id: ARO:3002389 name: OXY-1-1 namespace: antibiotic_resistance def: "OXY-1-1 is a beta-lactamase found in Klebsiella oxytoca." [PMID:23090395] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-1-1" EXACT CARD_Short_Name [] synonym: "OXY-1-7" EXACT [] [Term] id: ARO:3002390 name: OXY-1-2 namespace: antibiotic_resistance def: "OXY-1-2 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-1-2" EXACT CARD_Short_Name [] synonym: "OXY-1-5" EXACT [] [Term] id: ARO:3002391 name: OXY-1-3 namespace: antibiotic_resistance def: "OXY-1-3 is a beta-lactamase found in Klebsiella oxytoca." [PMID:12807183] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-1-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002392 name: OXY-1-4 namespace: antibiotic_resistance def: "OXY-1-4 is a beta-lactamase found in Klebsiella oxytoca." [PMID:12807183] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-1-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002394 name: OXY-1-6 namespace: antibiotic_resistance def: "OXY-1-6 is a beta-lactamase found in Klebsiella oxytoca." [PMID:10223957] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-1-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002396 name: OXY-2-1 namespace: antibiotic_resistance def: "OXY-2-1 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002397 name: OXY-2-2 namespace: antibiotic_resistance def: "OXY-2-2 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002398 name: OXY-2-3 namespace: antibiotic_resistance def: "OXY-2-3 is a beta-lactamase found in Klebsiella oxytoca." [PMID:12807183] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002399 name: OXY-2-4 namespace: antibiotic_resistance def: "OXY-2-4 is a beta-lactamase found in Klebsiella oxytoca." [PMID:10223957] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002400 name: OXY-2-5 namespace: antibiotic_resistance def: "OXY-2-5 is a beta-lactamase found in Klebsiella oxytoca." [PMID:12807183] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002401 name: OXY-2-6 namespace: antibiotic_resistance def: "OXY-2-6 is a beta-lactamase found in Klebsiella oxytoca." [PMID:12807183] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002402 name: OXY-2-7 namespace: antibiotic_resistance def: "OXY-2-7 is a beta-lactamase found in Klebsiella oxytoca." [PMID:7574532] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002403 name: OXY-2-8 namespace: antibiotic_resistance def: "OXY-2-8 is a beta-lactamase found in Klebsiella oxytoca." [PMID:12019142] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002404 name: OXY-2-9 namespace: antibiotic_resistance def: "OXY-2-9 is a beta-lactamase found in Klebsiella oxytoca." [PMID:21555768] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002405 name: OXY-2-10 namespace: antibiotic_resistance def: "OXY-2-10 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases." [] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002406 name: OXY-2-11 namespace: antibiotic_resistance def: "OXY-2-11 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases." [] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002407 name: OXY-2-12 namespace: antibiotic_resistance def: "OXY-2-12 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases." [] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002408 name: OXY-2-13 namespace: antibiotic_resistance def: "OXY-2-13 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases." [] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002409 name: OXY-3-1 namespace: antibiotic_resistance def: "OXY-3-1 is a beta-lactamase found in Klebsiella oxytoca." [PMID:12807183] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-3-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002410 name: OXY-4-1 namespace: antibiotic_resistance def: "OXY-4-1 is a beta-lactamase found in Klebsiella oxytoca." [PMID:12807183] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-4-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002411 name: OXY-5-1 namespace: antibiotic_resistance def: "OXY-5-1 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-5-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002412 name: OXY-5-2 namespace: antibiotic_resistance def: "OXY-5-2 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-5-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002413 name: OXY-6-1 namespace: antibiotic_resistance def: "OXY-6-1 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-6-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002414 name: OXY-6-2 namespace: antibiotic_resistance def: "OXY-6-2 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-6-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002415 name: OXY-6-3 namespace: antibiotic_resistance def: "OXY-6-3 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-6-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002416 name: OXY-6-4 namespace: antibiotic_resistance def: "OXY-6-4 is a beta-lactamase found in Klebsiella oxytoca." [PMID:16048960] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-6-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002417 name: OKP beta-lactamase namespace: antibiotic_resistance def: "OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%." [PMID:16304190, PMID:22143810] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3002418 name: OKP-A-1 namespace: antibiotic_resistance def: "OKP-A-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002419 name: OKP-A-2 namespace: antibiotic_resistance def: "OKP-A-2 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002420 name: OKP-A-3 namespace: antibiotic_resistance def: "OKP-A-3 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002421 name: OKP-A-4 namespace: antibiotic_resistance def: "OKP-A-4 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002422 name: OKP-A-5 namespace: antibiotic_resistance def: "OKP-A-5 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002423 name: OKP-A-6 namespace: antibiotic_resistance def: "OKP-A-6 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002424 name: OKP-A-7 namespace: antibiotic_resistance def: "OKP-A-7 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002425 name: OKP-A-8 namespace: antibiotic_resistance def: "OKP-A-8 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002426 name: OKP-A-9 namespace: antibiotic_resistance def: "OKP-A-9 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002427 name: OKP-A-10 namespace: antibiotic_resistance def: "OKP-A-10 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002428 name: OKP-A-11 namespace: antibiotic_resistance def: "OKP-A-11 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002429 name: OKP-A-12 namespace: antibiotic_resistance def: "OKP-A-12 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002430 name: OKP-A-13 namespace: antibiotic_resistance def: "OKP-A-13 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:22143810] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002431 name: OKP-A-14 namespace: antibiotic_resistance def: "OKP-A-14 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:22143810] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002432 name: OKP-A-15 namespace: antibiotic_resistance def: "OKP-A-15 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:22143810] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002433 name: OKP-A-16 namespace: antibiotic_resistance def: "OKP-A-16 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:22143810] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002434 name: OKP-B-1 namespace: antibiotic_resistance def: "OKP-B-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002435 name: OKP-B-2 namespace: antibiotic_resistance def: "OKP-B-2 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002436 name: OKP-B-3 namespace: antibiotic_resistance def: "OKP-B-3 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002437 name: OKP-B-4 namespace: antibiotic_resistance def: "OKP-B-4 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002438 name: OKP-B-5 namespace: antibiotic_resistance def: "OKP-B-5 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15980410] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002439 name: OKP-B-6 namespace: antibiotic_resistance def: "OKP-B-6 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15980410] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-15" EXACT [] synonym: "OKP-B-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002440 name: OKP-B-7 namespace: antibiotic_resistance def: "OKP-B-7 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002441 name: OKP-B-8 namespace: antibiotic_resistance def: "OKP-B-8 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002442 name: OKP-B-9 namespace: antibiotic_resistance def: "OKP-B-9 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002443 name: OKP-B-10 namespace: antibiotic_resistance def: "OKP-B-10 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002444 name: OKP-B-11 namespace: antibiotic_resistance def: "OKP-B-11 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16304190] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002445 name: OKP-B-12 namespace: antibiotic_resistance def: "OKP-B-12 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002446 name: OKP-B-13 namespace: antibiotic_resistance def: "OKP-B-13 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:16769193] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002447 name: OKP-B-14 namespace: antibiotic_resistance def: "OKP-B-14 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:17442542] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002450 name: OKP-B-17 namespace: antibiotic_resistance def: "OKP-B-17 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002451 name: OKP-B-18 namespace: antibiotic_resistance def: "OKP-B-18 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002452 name: OKP-B-19 namespace: antibiotic_resistance def: "OKP-B-19 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002453 name: OKP-B-20 namespace: antibiotic_resistance def: "OKP-B-20 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-20" EXACT CARD_Short_Name [] [Term] id: ARO:3002454 name: LEN-1 namespace: antibiotic_resistance def: "LEN-1 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:3533626] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002455 name: LEN-2 namespace: antibiotic_resistance def: "LEN-2 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002456 name: LEN-5 namespace: antibiotic_resistance def: "LEN-5 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002457 name: LEN-7 namespace: antibiotic_resistance def: "LEN-7 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002458 name: LEN-8 namespace: antibiotic_resistance def: "LEN-8 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002459 name: LEN-9 namespace: antibiotic_resistance def: "LEN-9 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002460 name: LEN-10 namespace: antibiotic_resistance def: "LEN-10 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002461 name: LEN-11 namespace: antibiotic_resistance def: "LEN-11 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-11" EXACT CARD_Short_Name [] [Term] id: ARO:3002462 name: LEN-12 namespace: antibiotic_resistance def: "LEN-12 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002463 name: LEN-13 namespace: antibiotic_resistance def: "LEN-13 is a beta-lactamase found in Klebsiella pneumoniae and Klebsiella variicola." [PMID:19965433, PMID:15215087] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002464 name: LEN-16 namespace: antibiotic_resistance def: "LEN-16 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:15980410] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-16" EXACT CARD_Short_Name [] [Term] id: ARO:3002465 name: LEN-18 namespace: antibiotic_resistance def: "LEN-18 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002466 name: LEN-19 namespace: antibiotic_resistance def: "LEN-19 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002467 name: LEN-20 namespace: antibiotic_resistance def: "LEN-20 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-20" EXACT CARD_Short_Name [] [Term] id: ARO:3002468 name: LEN-21 namespace: antibiotic_resistance def: "LEN-21 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-21" EXACT CARD_Short_Name [] [Term] id: ARO:3002469 name: LEN-22 namespace: antibiotic_resistance def: "LEN-22 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-22" EXACT CARD_Short_Name [] [Term] id: ARO:3002470 name: LEN-23 namespace: antibiotic_resistance def: "LEN-23 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-23" EXACT CARD_Short_Name [] [Term] id: ARO:3002471 name: LEN-24 namespace: antibiotic_resistance def: "LEN-24 is a beta-lactamase found in Klebsiella pneumoniae." [PMID:19128913] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-24" EXACT CARD_Short_Name [] [Term] id: ARO:3002472 name: LEN-4 namespace: antibiotic_resistance def: "LEN-4 is a beta-lactamase found in Escherichia coli." [PMID:22809702] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002473 name: LEN-17 namespace: antibiotic_resistance def: "LEN-17 is a beta-lactamase found in Escherichia coli." [PMID:22809702] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002474 name: LEN-26 namespace: antibiotic_resistance def: "LEN-26 is a beta-lactamase found in Escherichia coli and Klebsiella pneumoniae." [PMID:22809702] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-26" EXACT CARD_Short_Name [] [Term] id: ARO:3002475 name: LEN-3 namespace: antibiotic_resistance def: "LEN-3 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002476 name: LEN-6 namespace: antibiotic_resistance def: "LEN-6 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002477 name: LEN-14 namespace: antibiotic_resistance def: "LEN-14 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-14" EXACT CARD_Short_Name [] [Term] id: ARO:3002478 name: LEN-15 namespace: antibiotic_resistance def: "LEN-15 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-15" EXACT CARD_Short_Name [] [Term] id: ARO:3002479 name: LEN-25 namespace: antibiotic_resistance def: "LEN-25 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-25" EXACT CARD_Short_Name [] [Term] id: ARO:3002480 name: OXA-144 namespace: antibiotic_resistance def: "OXA-144 is a beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-144" EXACT CARD_Short_Name [] [Term] id: ARO:3002481 name: AER-1 namespace: antibiotic_resistance def: "AER-1 is a beta-lactamase found in Aeromonas hydrophila." [PMID:3890725] is_a: ARO:3000089 ! AER beta-lactamase synonym: "AER-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002482 name: LRA-1 namespace: antibiotic_resistance def: "LRA-1 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004228 ! class A LRA beta-lactamase synonym: "LRA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002483 name: LRA-5 namespace: antibiotic_resistance def: "LRA-5 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004228 ! class A LRA beta-lactamase synonym: "LRA-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002484 name: LRA-13 namespace: antibiotic_resistance def: "LRA-13 is a class D/class C fusion bifunctional beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004231 ! class C LRA beta-lactamase is_a: ARO:3004241 ! class D LRA beta-lactamase synonym: "LRA-13" EXACT CARD_Short_Name [] [Term] id: ARO:3002485 name: LRA-2 namespace: antibiotic_resistance def: "LRA-2 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004226 ! subclass B3 LRA beta-lactamase synonym: "LRA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002486 name: LRA-7 namespace: antibiotic_resistance def: "LRA-7 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004226 ! subclass B3 LRA beta-lactamase synonym: "LRA-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002487 name: LRA-8 namespace: antibiotic_resistance def: "LRA-8 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004226 ! subclass B3 LRA beta-lactamase synonym: "LRA-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002488 name: LRA-9 namespace: antibiotic_resistance def: "LRA-9 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004226 ! subclass B3 LRA beta-lactamase synonym: "LRA-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002489 name: LRA-10 namespace: antibiotic_resistance def: "LRA-10 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004231 ! class C LRA beta-lactamase synonym: "LRA-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002492 name: LRA-18 namespace: antibiotic_resistance def: "LRA-18 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004231 ! class C LRA beta-lactamase synonym: "LRA-18" EXACT CARD_Short_Name [] [Term] id: ARO:3002493 name: SRT-1 namespace: antibiotic_resistance def: "SRT-1, isolated from Serratia marcescens, confers resistance to cephalosporins but not carbapenems, penems and monobactams." [PMID:8540730] is_a: ARO:3000095 ! SRT beta-lactamase synonym: "SRT-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002494 name: SRT-2 namespace: antibiotic_resistance def: "SRT-2, isolated from Serratia marcescens, is a chromosomal beta-lactamase that confers resistance to cefotaxime." [PMID:15183862] is_a: ARO:3000095 ! SRT beta-lactamase synonym: "SRT-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002495 name: CTX-M-85 namespace: antibiotic_resistance def: "CTX-M-85 is a beta-lactamase found in Salmonella enterica." [PMID:18984647] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-85" EXACT CARD_Short_Name [] [Term] id: ARO:3002496 name: OXA-418 namespace: antibiotic_resistance def: "OXA-418 is a beta-lactamase. From the Lahey list of OXA beta-lactamases." [] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-418" EXACT CARD_Short_Name [] [Term] id: ARO:3002497 name: PDC-1 namespace: antibiotic_resistance def: "PDC-1 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002498 name: PDC-2 namespace: antibiotic_resistance def: "PDC-2 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002500 name: PDC-3 namespace: antibiotic_resistance def: "PDC-3 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272, PMID:33416461] is_a: ARO:3000098 ! PDC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000646 ! cefixime relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "PDC-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002501 name: PDC-4 namespace: antibiotic_resistance def: "PDC-4 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002502 name: PDC-5 namespace: antibiotic_resistance def: "PDC-5 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [PMID:33416461, PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000646 ! cefixime relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "PDC-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002505 name: PDC-6 namespace: antibiotic_resistance def: "PDC-6 is a beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002506 name: PDC-7 namespace: antibiotic_resistance def: "PDC-7 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002507 name: PDC-8 namespace: antibiotic_resistance def: "PDC-8 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002508 name: PDC-9 namespace: antibiotic_resistance def: "PDC-9 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "PDC-9" EXACT CARD_Short_Name [] [Term] id: ARO:3002509 name: PDC-10 namespace: antibiotic_resistance def: "PDC-10 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa." [PMID:19258272] is_a: ARO:3000098 ! PDC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "PDC-10" EXACT CARD_Short_Name [] [Term] id: ARO:3002510 name: LRA-3 namespace: antibiotic_resistance def: "LRA-3 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004226 ! subclass B3 LRA beta-lactamase synonym: "LRA-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002511 name: LRA-12 namespace: antibiotic_resistance def: "LRA-12 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004226 ! subclass B3 LRA beta-lactamase synonym: "LRA-12" EXACT CARD_Short_Name [] [Term] id: ARO:3002512 name: LRA-17 namespace: antibiotic_resistance def: "LRA-17 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004226 ! subclass B3 LRA beta-lactamase synonym: "LRA-17" EXACT CARD_Short_Name [] [Term] id: ARO:3002513 name: LRA-19 namespace: antibiotic_resistance def: "LRA-19 is a beta-lactamase isolated from soil samples in Alaska." [PMID:18843302] is_a: ARO:3004226 ! subclass B3 LRA beta-lactamase synonym: "LRA-19" EXACT CARD_Short_Name [] [Term] id: ARO:3002514 name: OCH-1 namespace: antibiotic_resistance def: "OCH-1 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi." [PMID:11451692] is_a: ARO:3000094 ! OCH beta-lactamase synonym: "OCH-1" EXACT CARD_Short_Name [] synonym: "Ochrobactrum anthropi" EXACT [] [Term] id: ARO:3002515 name: OCH-2 namespace: antibiotic_resistance def: "OCH-2 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi." [PMID:11451692] is_a: ARO:3000094 ! OCH beta-lactamase synonym: "OCH-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002516 name: OCH-3 namespace: antibiotic_resistance def: "OCH-3 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi." [PMID:11451692] is_a: ARO:3000094 ! OCH beta-lactamase synonym: "OCH-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002517 name: OCH-4 namespace: antibiotic_resistance def: "OCH-4 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi." [PMID:11451692] is_a: ARO:3000094 ! OCH beta-lactamase synonym: "OCH-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002518 name: OCH-5 namespace: antibiotic_resistance def: "OCH-5 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi." [PMID:11451692] is_a: ARO:3000094 ! OCH beta-lactamase synonym: "OCH-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002519 name: OCH-6 namespace: antibiotic_resistance def: "OCH-6 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi." [PMID:11451692] is_a: ARO:3000094 ! OCH beta-lactamase synonym: "OCH-6" EXACT CARD_Short_Name [] [Term] id: ARO:3002520 name: OCH-7 namespace: antibiotic_resistance def: "OCH-7 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi." [PMID:11451692] is_a: ARO:3000094 ! OCH beta-lactamase synonym: "OCH-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002521 name: OCH-8 namespace: antibiotic_resistance def: "OCH-8 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi." [PMID:11451692] is_a: ARO:3000094 ! OCH beta-lactamase synonym: "OCH-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002522 name: novA namespace: antibiotic_resistance def: "A type III ABC transporter, identified on the novobiocin biosynthetic gene cluster, involved in the transport and resistance of novobiocin." [PMID:12604514] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin synonym: "novA" EXACT CARD_Short_Name [] [Term] id: ARO:3002523 name: AAC(2')-Ia namespace: antibiotic_resistance def: "AAC(2')-Ia is a chromosomal-encoded aminoglycoside acetyltransferase in P. stuartii." [PMID:8407825] is_a: ARO:3007393 ! AAC(2')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(2')-Ia" EXACT CARD_Short_Name [] [Term] id: ARO:3002524 name: AAC(2')-Ib namespace: antibiotic_resistance def: "AAC(2')-Ib is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium fortuitum and A. baumannii." [PMID:8891143] is_a: ARO:3007393 ! AAC(2')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(2')-Ib" EXACT CARD_Short_Name [] [Term] id: ARO:3002525 name: AAC(2')-Ic namespace: antibiotic_resistance def: "AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis." [PMID:9159528] is_a: ARO:3007393 ! AAC(2')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(2')-Ic" EXACT CARD_Short_Name [] [Term] id: ARO:3002526 name: AAC(2')-Id namespace: antibiotic_resistance def: "AAC(2')-Id is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium smegmatis." [PMID:9159528] is_a: ARO:3007393 ! AAC(2')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(2')-Id" EXACT CARD_Short_Name [] [Term] id: ARO:3002527 name: AAC(2')-Ie namespace: antibiotic_resistance def: "AAC(2')-Ie is a chromosomal-encoded aminoglycoside acetyltransferase in M. leprae." [PMID:9159528] is_a: ARO:3007393 ! AAC(2')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(2')-Ie" EXACT CARD_Short_Name [] [Term] id: ARO:3002528 name: AAC(3)-Ia namespace: antibiotic_resistance def: "AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis." [PMID:2549372, PMID:1960117] is_a: ARO:3007384 ! AAC(3)-I relationship: confers_resistance_to_antibiotic ARO:0000003 ! astromicin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-Ia C" EXACT [] synonym: "AAC(3)-Ia" EXACT CARD_Short_Name [] synonym: "aacC-A1" EXACT [] synonym: "aacC1" EXACT [] [Term] id: ARO:3002529 name: AAC(3)-Id namespace: antibiotic_resistance def: "AAC(3)-Id is an aminoglycoside acetyltransferase encoded by genomic islands and integrons in S. enterica, P. mirabilis and Vibrio fluvialis." [PMID:15728939, PMID:15388438, PMID:18476779] is_a: ARO:3007384 ! AAC(3)-I relationship: confers_resistance_to_antibiotic ARO:0000003 ! astromicin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-Id" EXACT CARD_Short_Name [] synonym: "AAC(3)-Ie" EXACT [] synonym: "aacCA5" EXACT [] [Term] id: ARO:3002530 name: AAC(3)-Ib namespace: antibiotic_resistance def: "AAC(3)-Ib is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:7486920] is_a: ARO:3007384 ! AAC(3)-I relationship: confers_resistance_to_antibiotic ARO:0000003 ! astromicin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-Ib" EXACT CARD_Short_Name [] synonym: "aacCA2" EXACT [] [Term] id: ARO:3002531 name: AAC(3)-Ic namespace: antibiotic_resistance def: "AAC(3)-Ic is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:12709352] is_a: ARO:3007384 ! AAC(3)-I relationship: confers_resistance_to_antibiotic ARO:0000003 ! astromicin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-Ic" EXACT CARD_Short_Name [] synonym: "aacCA3" EXACT [] [Term] id: ARO:3002533 name: AAC(3)-IIa namespace: antibiotic_resistance def: "AAC(3)-IIa is a plasmid-encoded aminoglycoside acetyltransferase in K. pneumoniae, E. cloacae, Actinobacillus pleuropneumoniae, S. typhimurium, Citrobacter freundii, and P. aeruginosa." [PMID:3892230, PMID:8913451, PMID:8385262] is_a: ARO:3007385 ! AAC(3)-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IIa" EXACT CARD_Short_Name [] synonym: "aaC3" EXACT [] synonym: "aac(3)-Va" EXACT [] synonym: "aacC2" EXACT [] synonym: "aacC5" EXACT [] [Term] id: ARO:3002534 name: AAC(3)-IIb namespace: antibiotic_resistance def: "AAC(3)-IIb is an aminoglycoside acetyltransferase in E. coli, A. faecalis and S. marcescens." [PMID:8385262, PMID:1444303] is_a: ARO:3007385 ! AAC(3)-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IIb" EXACT CARD_Short_Name [] synonym: "aac(3)-Vb" EXACT [] [Term] id: ARO:3002535 name: AAC(3)-IIc namespace: antibiotic_resistance def: "AAC(3)-IIc is a plasmid-encoded aminoglycoside acetyltransferase in E. coli and P. aeruginosa." [PMID:18467306, PMID:8385262] is_a: ARO:3007385 ! AAC(3)-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IIc" EXACT CARD_Short_Name [] synonym: "aacC2" EXACT [] [Term] id: ARO:3002536 name: AAC(3)-IIIa namespace: antibiotic_resistance def: "AAC(3)-IIIa is a chromosomal-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:1649572] is_a: ARO:3007386 ! AAC(3)-III relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin relationship: confers_resistance_to_antibiotic ARO:3000658 ! lividomycin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IIIa" EXACT CARD_Short_Name [] synonym: "aacC3" EXACT [] [Term] id: ARO:3002537 name: AAC(3)-IIIb namespace: antibiotic_resistance def: "AAC(3)-IIIb is an aminoglycoside acetyltransferase in P. aeruginosa." [PMID:20387903] is_a: ARO:3007386 ! AAC(3)-III relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin relationship: confers_resistance_to_antibiotic ARO:3000658 ! lividomycin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IIIb" EXACT CARD_Short_Name [] [Term] id: ARO:3002538 name: AAC(3)-IIIc namespace: antibiotic_resistance def: "AAC(3)-IIIc is an aminoglycoside acetyltransferase in P. aeruginosa." [PMID:8385262] is_a: ARO:3007386 ! AAC(3)-III relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "AAC(3)-IIIc" EXACT CARD_Short_Name [] synonym: "ANT(2'')-Ib" EXACT [] [Term] id: ARO:3002539 name: AAC(3)-IVa namespace: antibiotic_resistance def: "AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri." [PMID:6318050, PMID:19709289] is_a: ARO:3007387 ! AAC(3)-IV relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000037 ! apramycin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IVa" EXACT CARD_Short_Name [] synonym: "aacC4" EXACT [] [Term] id: ARO:3002540 name: AAC(3)-VIa namespace: antibiotic_resistance def: "AAC(3)-VIa is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae, S. enterica and E. coli." [PMID:19949054, PMID:8257126] is_a: ARO:3007388 ! AAC(3)-VI relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-VIa" EXACT CARD_Short_Name [] [Term] id: ARO:3002541 name: AAC(3)-VIIa namespace: antibiotic_resistance def: "AAC(3)-VIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces rimosus." [PMID:2914849] is_a: ARO:3007389 ! AAC(3)-VII relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "AAC(3)-VIIa" EXACT CARD_Short_Name [] synonym: "aacC7" EXACT [] [Term] id: ARO:3002542 name: AAC(3)-VIIIa namespace: antibiotic_resistance def: "AAC(3)-VIIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces fradiae." [PMID:2060791] is_a: ARO:3007390 ! AAC(3)-VIII relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin synonym: "AAC(3)-VIIIa" EXACT CARD_Short_Name [] synonym: "aacC8" EXACT [] [Term] id: ARO:3002543 name: AAC(3)-IXa namespace: antibiotic_resistance def: "AAC(3)-IXa is a chromosomal-encoded aminoglycoside acetyltransferase in Micromonospora chalcea." [PMID:2060791] is_a: ARO:3007391 ! AAC(3)-IX relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin synonym: "AAC(3)-IXa" EXACT CARD_Short_Name [] synonym: "aacC9" EXACT [] [Term] id: ARO:3002544 name: AAC(3)-Xa namespace: antibiotic_resistance def: "AAC(3)-Xa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces griseus." [PMID:10639379] is_a: ARO:3007392 ! AAC(3)-X relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "AAC(3)-Xa" EXACT CARD_Short_Name [] [Term] id: ARO:3002545 name: AAC(6')-Ia namespace: antibiotic_resistance def: "AAC(6')-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Citrobacter diversus, E. coli, K. pneumoniae, Shigella sonnei, and P. aeruginosa." [PMID:1314803, PMID:2826403] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ia" EXACT CARD_Short_Name [] synonym: "aacA1" EXACT [] [Term] id: ARO:3002546 name: AAC(6')-Ib namespace: antibiotic_resistance def: "AAC(6')-Ib is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in K. pneumoniae, P. mirabilis, P. aeruginosa, S. enterica, K. oxytoca, S. maltophilia, E. cloacae and V. cholerae." [PMID:2841303, PMID:2824444, PMID:16641475] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-4" EXACT [] synonym: "AAC(6')-Ib" EXACT CARD_Short_Name [] synonym: "aacA4" EXACT [] [Term] id: ARO:3002547 name: AAC(6')-Ib-cr1 namespace: antibiotic_resistance def: "AAC(6')-Ib-cr is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Enterobacteriaceae. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously." [PMID:16369542, PMID:18812424, PMID:18710261] is_a: ARO:3005113 ! AAC(6')-Ib-cr relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-cr1" EXACT CARD_Short_Name [] xref: PDB:1V0C [Term] id: ARO:3002549 name: AAC(6')-Ic namespace: antibiotic_resistance def: "AAC(6')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in S. marcescens." [PMID:1354954] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-III" EXACT [] synonym: "AAC(6')-Ic" EXACT CARD_Short_Name [] [Term] id: ARO:3002553 name: AAC(6')-If namespace: antibiotic_resistance def: "AAC(6')-If is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae." [PMID:7695286] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-If" EXACT CARD_Short_Name [] [Term] id: ARO:3002554 name: AAC(6')-Ig namespace: antibiotic_resistance def: "AAC(6')-Ig is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter haemolyticus." [PMID:7810994, PMID:8257129] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ig" EXACT CARD_Short_Name [] [Term] id: ARO:3002555 name: AAC(6')-Ih namespace: antibiotic_resistance def: "AAC(6')-Ih is a plasmid-encoded aminoglycoside acetyltransferase in A. baumannii." [PMID:7810994] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ih" EXACT CARD_Short_Name [] [Term] id: ARO:3002556 name: AAC(6')-Ii namespace: antibiotic_resistance def: "AAC(6')-Ii is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus spp." [PMID:10378269, PMID:8239603, PMID:12767240] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ii" EXACT CARD_Short_Name [] [Term] id: ARO:3002557 name: AAC(6')-Ij namespace: antibiotic_resistance def: "AAC(6')-Ij is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 13." [PMID:7810994] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ij" EXACT CARD_Short_Name [] [Term] id: ARO:3002558 name: AAC(6')-Ik namespace: antibiotic_resistance def: "AAC(6')-Ik is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp." [PMID:8001769] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ik" EXACT CARD_Short_Name [] [Term] id: ARO:3002559 name: AAC(6')-Ip namespace: antibiotic_resistance def: "AAC(6')-Ip is an aminoglycoside acetyltransferase encoded by plasmids and integrons in C. freundii, E. coli, E. faecium and Klebsiella aerogenes." [PMID:9021185, PMID:11557456, PMID:7793874] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ip" EXACT CARD_Short_Name [] synonym: "aacA16" EXACT [] [Term] id: ARO:3002560 name: AAC(6')-Iq namespace: antibiotic_resistance def: "AAC(6')-Iq is a aminoglycoside acetyltransferase encoded by plasmids and integrons in K. pneumoniae." [PMID:9624504] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iq" EXACT CARD_Short_Name [] [Term] id: ARO:3002561 name: AAC(6')-Ir namespace: antibiotic_resistance def: "AAC(6')-Ir is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter colistiniresistens." [PMID:10188279] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ir" EXACT CARD_Short_Name [] [Term] id: ARO:3002562 name: AAC(6')-Is namespace: antibiotic_resistance def: "AAC(6')-Is is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter variabilis." [PMID:10188279] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Is" EXACT CARD_Short_Name [] [Term] id: ARO:3002563 name: AAC(6')-Isa namespace: antibiotic_resistance def: "AAC(6')-Isa is a plasmid-encoded aminoglycoside acetyltransferase in Streptomyces albulus." [PMID:15625322] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Isa" EXACT CARD_Short_Name [] [Term] id: ARO:3002564 name: AAC(6')-It namespace: antibiotic_resistance def: "AAC(6')-It is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 16." [PMID:10188279] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-It" EXACT CARD_Short_Name [] [Term] id: ARO:3002565 name: AAC(6')-Iu namespace: antibiotic_resistance def: "AAC(6')-Iu is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 17." [PMID:10188279] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iu" EXACT CARD_Short_Name [] [Term] id: ARO:3002566 name: AAC(6')-Iv namespace: antibiotic_resistance def: "AAC(6')-Iv is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp." [PMID:10188279] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iv" EXACT CARD_Short_Name [] [Term] id: ARO:3002567 name: AAC(6')-Iw namespace: antibiotic_resistance def: "AAC(6')-Iw is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp." [PMID:10188279] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iw" EXACT CARD_Short_Name [] [Term] id: ARO:3002568 name: AAC(6')-Ix namespace: antibiotic_resistance def: "AAC(6')-Ix is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp." [PMID:10188279] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ix" EXACT CARD_Short_Name [] [Term] id: ARO:3002569 name: AAC(6')-Iy namespace: antibiotic_resistance def: "AAC(6')-Iy is a chromosomal-encoded aminoglycoside acetyltransferase in S. enteritidis and S. enterica. Regulatory mutation required to increase expression of this chromosomally-encoded gene for resistance. In the specific system, aminoglycoside resistance was due to a transcriptional fusion secondary to a chromosomal deletion in which the downstream aac(6')-Iy gene was placed under the control of the upstream nmpC promoter." [PMID:10542165] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iy" EXACT CARD_Short_Name [] [Term] id: ARO:3002570 name: AAC(6')-Iz namespace: antibiotic_resistance def: "AAC(6')-Iz is a chromosomal-encoded aminoglycoside acetyltransferase in S. maltophilia." [PMID:10508008] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iz" EXACT CARD_Short_Name [] [Term] id: ARO:3002571 name: AAC(6')-Iaa namespace: antibiotic_resistance def: "AAC(6')-Iaa is a chromosomal-encoded aminoglycoside acetyltransferase in S. typhimurium." [PMID:12679553] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iaa" EXACT CARD_Short_Name [] [Term] id: ARO:3002572 name: AAC(6')-Iad namespace: antibiotic_resistance def: "AAC(6')-Iad is a plasmid-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 3." [PMID:15155202] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iad" EXACT CARD_Short_Name [] [Term] id: ARO:3002573 name: AAC(6')-Iae namespace: antibiotic_resistance def: "AAC(6')-Iae is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa and S. enterica." [PMID:16127047] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iae" EXACT CARD_Short_Name [] [Term] id: ARO:3002574 name: AAC(6')-Iaf namespace: antibiotic_resistance def: "AAC(6')-Iaf is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa." [PMID:19349516] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iaf" EXACT CARD_Short_Name [] [Term] id: ARO:3002575 name: AAC(6')-Iai namespace: antibiotic_resistance def: "AAC(6')-Iai is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa." [PMID:26270859] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iai" EXACT CARD_Short_Name [] [Term] id: ARO:3002576 name: AAC(6')-Ib3 namespace: antibiotic_resistance def: "AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:1331747, PMID:9527761] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib3" EXACT CARD_Short_Name [] synonym: "AAC(6')-Ib5" EXACT [] synonym: "aacA4" EXACT [] [Term] id: ARO:3002577 name: AAC(6')-Ib4 namespace: antibiotic_resistance def: "AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp." [PMID:1339319] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib4" EXACT CARD_Short_Name [] [Term] id: ARO:3002578 name: AAC(6')-Ib7 namespace: antibiotic_resistance def: "AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii." [PMID:9527761] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib7" EXACT CARD_Short_Name [] [Term] id: ARO:3002579 name: AAC(6')-Ib8 namespace: antibiotic_resistance def: "AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae." [PMID:9527761] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib8" EXACT CARD_Short_Name [] [Term] id: ARO:3002580 name: AAC(6')-Ib9 namespace: antibiotic_resistance def: "AAC(6')-Ib9 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:9835500] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib9" EXACT CARD_Short_Name [] [Term] id: ARO:3002581 name: AAC(6')-Ib10 namespace: antibiotic_resistance def: "AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:9579076] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib10" EXACT CARD_Short_Name [] [Term] id: ARO:3002582 name: AAC(6')-Ib11 namespace: antibiotic_resistance def: "AAC(6')-Ib11 is an integron-encoded aminoglycoside acetyltransferase in S. enterica." [PMID:12543680] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib11" EXACT CARD_Short_Name [] [Term] id: ARO:3002583 name: AAC(6')-29a namespace: antibiotic_resistance def: "AAC(6')-29a is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:11158753] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin synonym: "AAC(6')-29a" EXACT CARD_Short_Name [] [Term] id: ARO:3002584 name: AAC(6')-29b namespace: antibiotic_resistance def: "AAC(6')-29b is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:11158753] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin synonym: "AAC(6')-29b" EXACT CARD_Short_Name [] [Term] id: ARO:3002585 name: AAC(6')-31 namespace: antibiotic_resistance def: "AAC(6')-31 is an integron-encoded aminoglycoside acetyltransferase in Pseudomonas putida, A. baumannii and K. pneumoniae." [PMID:17470660] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(6')-31" EXACT CARD_Short_Name [] [Term] id: ARO:3002586 name: AAC(6')-32 namespace: antibiotic_resistance def: "AAC(6')-32 is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa." [PMID:17938181] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(6')-32" EXACT CARD_Short_Name [] [Term] id: ARO:3002587 name: AAC(6')-I33 namespace: antibiotic_resistance def: "AAC(6')-I33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:19738007] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-I33" EXACT CARD_Short_Name [] [Term] id: ARO:3002588 name: AAC(6')-I30 namespace: antibiotic_resistance def: "AAC(6')-I30 is an integron-encoded aminoglycoside acetyltransferase in S. enterica." [PMID:15231768] is_a: ARO:3000345 ! AAC(6') is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-I30" EXACT CARD_Short_Name [] [Term] id: ARO:3002589 name: AAC(6')-Iid namespace: antibiotic_resistance def: "AAC(6')-Iid is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus durans." [PMID:15849260] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iid" EXACT CARD_Short_Name [] [Term] id: ARO:3002590 name: AAC(6')-Iih namespace: antibiotic_resistance def: "AAC(6')-Iih is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus hirae." [PMID:15849260] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iih" EXACT CARD_Short_Name [] [Term] id: ARO:3002591 name: AAC(6')-Ib-Suzhou namespace: antibiotic_resistance def: "AAC(6')-Ib-Suzhou is an aminoglycoside acetyltransferase in E. cloacae and K. pneumoniae." [PMID:18843996] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC_6_IB_Su" EXACT CARD_Short_Name [] [Term] id: ARO:3002592 name: AAC(6')-Ib-Hangzhou namespace: antibiotic_resistance def: "AAC(6')-Ib-Hangzhou is an aminoglycoside acetyltransferase in A. baumannii." [PMID:20833577] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC6_IB_HZ" EXACT CARD_Short_Name [] [Term] id: ARO:3002593 name: AAC(6')-Ib-SK namespace: antibiotic_resistance def: "AAC(6')-Ib-SK is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces kanamyceticus." [PMID:3838980] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-SK" EXACT CARD_Short_Name [] synonym: "AAC(6')-SK" EXACT [] synonym: "kac" EXACT [] [Term] id: ARO:3002594 name: AAC(6')-IIa namespace: antibiotic_resistance def: "AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica." [PMID:2515793] is_a: ARO:3007396 ! AAC(6')-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(6')-IIa" EXACT CARD_Short_Name [] [Term] id: ARO:3002595 name: AAC(6')-IIb namespace: antibiotic_resistance def: "AAC(6')-IIb is an integron-encoded aminoglycoside acetyltransferase in P. fluorescens." [PMID:8385262] is_a: ARO:3007396 ! AAC(6')-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(6')-IIb" EXACT CARD_Short_Name [] [Term] id: ARO:3002596 name: AAC(6')-IIc namespace: antibiotic_resistance def: "AAC(6')-IIc is an aminoglycoside acetyltransferase encoded by plasmids and integrons in E. cloacae." [PMID:15761066] is_a: ARO:3007396 ! AAC(6')-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(6')-IIc" EXACT CARD_Short_Name [] [Term] id: ARO:3002597 name: AAC(6')-Ie-APH(2'')-Ia bifunctional protein namespace: antibiotic_resistance def: "AAC(6')-Ie-APH(2'')-Ia is an aminoglycoside acetyltransferase encoded by plasmids and transposons in S. aureus, E. faecalis, E. faecium and Staphylococcus warneri." [PMID:10021417, PMID:2833561] is_a: ARO:3007419 ! aminoglycoside bifunctional resistance protein relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC6_Ie_APH2_Ia" EXACT CARD_Short_Name [] synonym: "APH(2''), aph(2'')-bifunctional, AAC(6')-APH(2'')" EXACT [] synonym: "aac(6')-bifunctional" EXACT [] synonym: "aacA-aphD" EXACT [] [Term] id: ARO:3002598 name: ANT(3'')-II-AAC(6')-IId bifunctional protein namespace: antibiotic_resistance def: "ANT(3'')-II-AAC(6')-IId is an integron-encoded aminoglycoside acetyltransferase in S. marcescens." [PMID:11959575] is_a: ARO:3007419 ! aminoglycoside bifunctional resistance protein relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "ANT3II_ANT6II" EXACT CARD_Short_Name [] [Term] id: ARO:3002599 name: AAC(6')-30/AAC(6')-Ib' bifunctional protein namespace: antibiotic_resistance def: "AAC(6')-30/AAC(6')-Ib' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:15561846] is_a: ARO:3007419 ! aminoglycoside bifunctional resistance protein relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "AAC6_30_AAC6_Ib" EXACT CARD_Short_Name [] [Term] id: ARO:3002600 name: AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein namespace: antibiotic_resistance def: "AAC(3)-Ib/AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa." [PMID:11850242] is_a: ARO:3007419 ! aminoglycoside bifunctional resistance protein relationship: confers_resistance_to_antibiotic ARO:0000003 ! astromicin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC_3Ib_AAC_6Ib" EXACT CARD_Short_Name [] [Term] id: ARO:3002601 name: aadA namespace: antibiotic_resistance def: "ANT(3'')-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons, integrons in Enterobacteriaceae, A. baumannii, P. aeruginosa and Vibrio cholerae." [PMID:2986186] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA" EXACT CARD_Short_Name [] synonym: "aadA, aadA1, aad(3'')(9)" EXACT [] synonym: "aadA1-pm" EXACT [] [Term] id: ARO:3002602 name: aadA2 namespace: antibiotic_resistance def: "aadA2 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in K. pneumoniae, Salmonella spp., Corynebacterium glutamicum, C. freundii and Aeromonas spp." [PMID:17526756] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA2" EXACT CARD_Short_Name [] [Term] id: ARO:3002603 name: aadA3 namespace: antibiotic_resistance def: "aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli." [PMID:1314803] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA3" EXACT CARD_Short_Name [] [Term] id: ARO:3002604 name: aadA4 namespace: antibiotic_resistance def: "aadA4 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Bordetella parapertussis and E. coli." [PMID:18458128, PMID:12910271] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA4" EXACT CARD_Short_Name [] [Term] id: ARO:3002605 name: aadA5 namespace: antibiotic_resistance def: "aadA5 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli, K. pneumoniae, Kluyvera georgiana, P. aeruginosa and E. cloacae." [PMID:10582907] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA5" EXACT CARD_Short_Name [] [Term] id: ARO:3002606 name: aadA6 namespace: antibiotic_resistance def: "aadA6 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa." [PMID:10673049] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA6" EXACT CARD_Short_Name [] [Term] id: ARO:3002607 name: aadA7 namespace: antibiotic_resistance def: "aadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica." [PMID:15117923] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA7" EXACT CARD_Short_Name [] [Term] id: ARO:3002608 name: aadA8 namespace: antibiotic_resistance def: "aadA8 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in V. cholerae, K. pneumoniae and Bacillus endophyticus." [PMID:19719593] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA8" EXACT CARD_Short_Name [] [Term] id: ARO:3002609 name: aadA9 namespace: antibiotic_resistance def: "aadA9 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in C. glutamicum." [PMID:12383729] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA9" EXACT CARD_Short_Name [] [Term] id: ARO:3002611 name: aadA11 namespace: antibiotic_resistance def: "aadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa." [PMID:16451415] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA11" EXACT CARD_Short_Name [] [Term] id: ARO:3002612 name: aadA12 namespace: antibiotic_resistance def: "aadA12 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli, Yersinia enterocolitica and S. enterica." [PMID:19538087] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA12" EXACT CARD_Short_Name [] [Term] id: ARO:3002613 name: aadA13 namespace: antibiotic_resistance def: "aadA13 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in Pseudomonas rettgeri, P. aeruginosa, Y. enterocolitica and E. coli." [PMID:18268088] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA13" EXACT CARD_Short_Name [] [Term] id: ARO:3002614 name: aadA14 namespace: antibiotic_resistance def: "aadA14 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in Pasteurella multocida." [PMID:15980396] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA14" EXACT CARD_Short_Name [] [Term] id: ARO:3002615 name: aadA15 namespace: antibiotic_resistance def: "aadA15 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa." [PMID:16816399] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA15" EXACT CARD_Short_Name [] [Term] id: ARO:3002616 name: aadA16 namespace: antibiotic_resistance def: "aadA16 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in E. coli, V. cholerae and K. pneumoniae." [PMID:19008256] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA16" EXACT CARD_Short_Name [] [Term] id: ARO:3002617 name: aadA17 namespace: antibiotic_resistance def: "aadA17 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Aeromonas media." [PMID:22127350] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA17" EXACT CARD_Short_Name [] [Term] id: ARO:3002618 name: aadA21 namespace: antibiotic_resistance def: "aadA21 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp." [PMID:12760885] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA21" EXACT CARD_Short_Name [] [Term] id: ARO:3002619 name: aadA22 namespace: antibiotic_resistance def: "aadA22 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in S. enterica and E. coli." [PMID:17597002] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA22" EXACT CARD_Short_Name [] [Term] id: ARO:3002620 name: aadA23 namespace: antibiotic_resistance def: "aadA23 is an integron-encoded aminoglycoside nucleotidyltransferase gene in S. enterica." [PMID:15761062] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA23" EXACT CARD_Short_Name [] [Term] id: ARO:3002621 name: aadA24 namespace: antibiotic_resistance def: "aadA24 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp." [PMID:17650961] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA24" EXACT CARD_Short_Name [] [Term] id: ARO:3002622 name: aadA6/aadA10 namespace: antibiotic_resistance def: "aadA6/aadA10 is an integron-encoded aminoglycoside nucleotidyltransferase gene cassette in P. aeruginosa." [PMID:16495246] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA6/aadA10" EXACT CARD_Short_Name [] [Term] id: ARO:3002623 name: ANT(4')-Ia namespace: antibiotic_resistance def: "ANT(4')-Ia is a plasmid-encoded aminoglycoside nucleotidyltransferase in S. epidermidis, S. aureus, Enterococcus spp. and Bacillus spp." [PMID:3010356, PMID:659332] is_a: ARO:3007403 ! ANT(4')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin synonym: "ANT(4')-Ia" EXACT CARD_Short_Name [] synonym: "aadD1" EXACT [] [Term] id: ARO:3002624 name: ANT(4')-IIa namespace: antibiotic_resistance def: "ANT(4')-IIa is a plasmid-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa and Enterobacteriaceae." [PMID:1965106, PMID:8494365] is_a: ARO:3007404 ! ANT(4')-II relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin synonym: "ANT(4')-IIa" EXACT CARD_Short_Name [] [Term] id: ARO:3002625 name: ANT(4')-IIb namespace: antibiotic_resistance def: "ANT(4')-IIb is a transposon-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa." [PMID:12709326] is_a: ARO:3007404 ! ANT(4')-II relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin synonym: "ANT(4')-IIb" EXACT CARD_Short_Name [] [Term] id: ARO:3002626 name: ANT(6)-Ia namespace: antibiotic_resistance def: "ANT(6)-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Staphylococcus epidermidis, E. faecium, Streptococcus suis, S. aureus, E. faecalis and Streptococcus mitis." [PMID:15774886, PMID:2168151, PMID:19603075] is_a: ARO:3007399 ! ANT(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "ANT(6)-Ia" EXACT CARD_Short_Name [] synonym: "ant6, aadE" EXACT [] [Term] id: ARO:3002627 name: aadK namespace: antibiotic_resistance def: "aadK is a chromosomal-encoded aminoglycoside nucleotidyltransferase gene in B. subtilis and Bacillus spp. This enzyme confers low-level resistance to streptomycin." [PMID:2550327, PMID:8293959] is_a: ARO:3007399 ! ANT(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadK" EXACT CARD_Short_Name [] [Term] id: ARO:3002628 name: aad(6) namespace: antibiotic_resistance def: "ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis." [PMID:11735367, PMID:17407061] is_a: ARO:3007399 ! ANT(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aac(6)" EXACT [] synonym: "aad(6)" EXACT CARD_Short_Name [] [Term] id: ARO:3002629 name: ANT(6)-Ib namespace: antibiotic_resistance def: "ANT(6)-Ib is an aminoglycoside nucleotidyltransferase gene encoded by transferable pathogenicity islands in C. fetus subsp. fetus and B. subtilis." [PMID:20479200] is_a: ARO:3007399 ! ANT(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "ANT(6)-Ib" EXACT CARD_Short_Name [] [Term] id: ARO:3002630 name: ANT(9)-Ia namespace: antibiotic_resistance def: "ANT(9)-Ia is an aminoglycoside nucleotidyltransferase encoded by plasmids and transposons in S. aureus, Enterococcus spp., Mammaliicoccus sciuri, and E. faecalis." [PMID:23511231, PMID:2993813, PMID:3004956] is_a: ARO:3007400 ! ANT(9)-I relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "ANT(9)-Ia" EXACT CARD_Short_Name [] synonym: "aad(9)" EXACT [] synonym: "aad9" EXACT [] synonym: "spc" EXACT [] synonym: "spw" EXACT [] [Term] id: ARO:3002631 name: spd namespace: antibiotic_resistance def: "spd is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in S. aureus." [PMID:24402501] is_a: ARO:3007400 ! ANT(9)-I relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "spd" EXACT CARD_Short_Name [] [Term] id: ARO:3002634 name: APH(2'')-Ie namespace: antibiotic_resistance def: "APH(2'')-Ie is a plasmid or transposon-encoded aminoglycoside phosphotransferase in E. faecium and E. casseliflavus." [PMID:17030911] is_a: ARO:3000128 ! APH(2'') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "APH(2'')-Ie" EXACT CARD_Short_Name [] [Term] id: ARO:3002635 name: APH(2'')-IIa namespace: antibiotic_resistance def: "APH(2'')-IIa is a chromosomal-encoded aminoglycoside phosphotransferase in E. faecium and E. coli." [PMID:10991878] is_a: ARO:3000128 ! APH(2'') relationship: confers_resistance_to_antibiotic ARO:3003675 ! plazomicin synonym: "APH(2'')-IIa" EXACT CARD_Short_Name [] synonym: "aph(2'')-Ib" EXACT [] xref: PDB:3HAV [Term] id: ARO:3002636 name: APH(2'')-IIIa namespace: antibiotic_resistance def: "APH(2'')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in Enterococcus gallinarum." [PMID:9055984] is_a: ARO:3000128 ! APH(2'') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "APH(2'')-IIIa" EXACT CARD_Short_Name [] synonym: "aph(2'')-Ic" EXACT [] [Term] id: ARO:3002637 name: APH(2'')-IVa namespace: antibiotic_resistance def: "APH(2'')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in E. casseliflavus." [PMID:9593155] is_a: ARO:3000128 ! APH(2'') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "APH(2'')-IVa" EXACT CARD_Short_Name [] synonym: "aph(2'')-Id" EXACT [] xref: PDB:3N4T [Term] id: ARO:3002638 name: APH(3'')-Ia namespace: antibiotic_resistance def: "APH(3'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus." [PMID:2167474] is_a: ARO:3007414 ! APH(3'')-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "APH(3'')-Ia" EXACT CARD_Short_Name [] synonym: "aphD2" EXACT [] synonym: "aphE" EXACT [] [Term] id: ARO:3002639 name: APH(3'')-Ib namespace: antibiotic_resistance def: "APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp." [PMID:2653965] is_a: ARO:3007414 ! APH(3'')-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "APH(3'')-Ib" EXACT CARD_Short_Name [] synonym: "orfH" EXACT [] synonym: "strA" EXACT [] [Term] id: ARO:3002640 name: APH(3'')-Ic namespace: antibiotic_resistance def: "APH(3'')-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in Mycolicibacterium fortuitum." [PMID:16954315] is_a: ARO:3007414 ! APH(3'')-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "APH(3'')-Ic" EXACT CARD_Short_Name [] [Term] id: ARO:3002641 name: APH(3')-Ia namespace: antibiotic_resistance def: "APH(3')-Ia is a transposon-encoded aminoglycoside phosphotransferase in E. coli and S. enterica. It is identical at the protein sequence to APH(3')-Ic, an aminoglycoside phosphotransferase encoded by plasmids, transposons and genomic islands in K. pneumoniae, A. baumannii, S. marcescens, Corynebacterium spp., Photobacterium spp. and Citrobacter spp." [PMID:6270337, PMID:10732668, PMID:2160941] is_a: ARO:3007406 ! APH(3')-I relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin relationship: confers_resistance_to_antibiotic ARO:3000658 ! lividomycin synonym: "APH(3')-Ia" EXACT CARD_Short_Name [] synonym: "APH(3')-Ic" EXACT [] synonym: "aphA-1" EXACT [] synonym: "apha1-1AB" EXACT [] synonym: "apha7" EXACT [] [Term] id: ARO:3002642 name: APH(3')-Ib namespace: antibiotic_resistance def: "APH(3')-Ib is a plasmid-encoded aminoglycoside phosphotransferase in E. coli." [PMID:2832861] is_a: ARO:3007406 ! APH(3')-I relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin relationship: confers_resistance_to_antibiotic ARO:3000658 ! lividomycin synonym: "APH(3')-Ib" EXACT CARD_Short_Name [] synonym: "aphA-like" EXACT [] [Term] id: ARO:3002644 name: APH(3')-IIa namespace: antibiotic_resistance def: "APH(3')-IIa is a transposon-encoded aminoglycoside phosphotransferase in E. coli." [PMID:6295884] is_a: ARO:3007408 ! APH(3')-II relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000024 ! butirosin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-IIa" EXACT CARD_Short_Name [] synonym: "aphA-2" EXACT [] xref: PDB:1ND4 [Term] id: ARO:3002645 name: APH(3')-IIb namespace: antibiotic_resistance def: "APH(3')-IIb is a chromosomal-encoded aminoglycoside phosphotransferase in P. aeruginosa." [PMID:10984043, PMID:14638496] is_a: ARO:3007408 ! APH(3')-II relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000024 ! butirosin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-IIb" EXACT CARD_Short_Name [] synonym: "APH(3')-IIps" EXACT [] [Term] id: ARO:3002646 name: APH(3')-IIc namespace: antibiotic_resistance def: "APH(3')-IIc is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia." [PMID:17088477] is_a: ARO:3007408 ! APH(3')-II relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000024 ! butirosin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-IIc" EXACT CARD_Short_Name [] [Term] id: ARO:3002647 name: APH(3')-IIIa namespace: antibiotic_resistance def: "APH(3')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in S. aureus and Enterococcus spp." [PMID:6313476] is_a: ARO:3007409 ! APH(3')-III relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000024 ! butirosin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin relationship: confers_resistance_to_antibiotic ARO:3000658 ! lividomycin synonym: "APH(3')-IIIa" EXACT CARD_Short_Name [] xref: PDB:1L8T [Term] id: ARO:3002648 name: APH(3')-IVa namespace: antibiotic_resistance def: "APH(3')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in Niallia circulans." [PMID:3006668] is_a: ARO:3007410 ! APH(3')-IV relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000024 ! butirosin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-IVa" EXACT CARD_Short_Name [] synonym: "aphA-4" EXACT [] [Term] id: ARO:3002649 name: APH(3')-Va namespace: antibiotic_resistance def: "APH(3')-Va is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces fradiae." [PMID:6310563] is_a: ARO:3007411 ! APH(3')-V relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-Va" EXACT CARD_Short_Name [] synonym: "aphA-5a" EXACT [] [Term] id: ARO:3002650 name: APH(3')-Vb namespace: antibiotic_resistance def: "APH(3')-Vb is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces ribosidificus." [PMID:2851496] is_a: ARO:3007411 ! APH(3')-V relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-Vb" EXACT CARD_Short_Name [] synonym: "aphA-5b, rph" EXACT [] [Term] id: ARO:3002651 name: APH(3')-Vc namespace: antibiotic_resistance def: "APH(3')-Vc is a chromosomal-encoded aminoglycoside phosphotransferase in M. chalcea." [PMID:1663923] is_a: ARO:3007411 ! APH(3')-V relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-Vc" EXACT CARD_Short_Name [] synonym: "aphA-5c" EXACT [] [Term] id: ARO:3002652 name: APH(3')-VIa namespace: antibiotic_resistance def: "APH(3')-VIa is a plasmid-encoded aminoglycoside phosphotransferase in A. baumannii." [PMID:2846986] is_a: ARO:3007412 ! APH(3')-VI relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000024 ! butirosin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-VIa" EXACT CARD_Short_Name [] synonym: "aphA-6" EXACT [] [Term] id: ARO:3002653 name: APH(3')-VIb namespace: antibiotic_resistance def: "APH(3')-VIb is a plasmid-encoded aminoglycoside phosphotransferase in K. pneumoniae and S. marcescens." [PMID:2848443] is_a: ARO:3007412 ! APH(3')-VI relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:0000024 ! butirosin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin relationship: confers_resistance_to_antibiotic ARO:3000655 ! gentamicin B relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "APH(3')-VIb" EXACT CARD_Short_Name [] [Term] id: ARO:3002654 name: APH(3')-VIIa namespace: antibiotic_resistance def: "APH(3')-VIIa is a plasmid-encoded aminoglycoside phosphotransferase in C. jejuni." [PMID:2550983] is_a: ARO:3007413 ! APH(3')-VII relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "APH(3')-VIIa" EXACT CARD_Short_Name [] synonym: "aphA-7" EXACT [] [Term] id: ARO:3002655 name: APH(4)-Ia namespace: antibiotic_resistance def: "APH(4)-Ia is a plasmid-encoded aminoglycoside phosphotransferase in E. coli." [PMID:6314265] is_a: ARO:3007418 ! APH(4)-I relationship: confers_resistance_to_antibiotic ARO:3000214 ! hygromycin B synonym: "APH(4)-Ia" EXACT CARD_Short_Name [] synonym: "hph" EXACT [] xref: PDB:3OVC [Term] id: ARO:3002656 name: APH(4)-Ib namespace: antibiotic_resistance def: "APH(4)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in Pseudomonas pseudomallei." [PMID:3005976] is_a: ARO:3007418 ! APH(4)-I relationship: confers_resistance_to_antibiotic ARO:3000214 ! hygromycin B synonym: "APH(4)-Ib" EXACT CARD_Short_Name [] synonym: "hyg" EXACT [] [Term] id: ARO:3002657 name: APH(6)-Ia namespace: antibiotic_resistance def: "APH(6)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus." [PMID:3118332] is_a: ARO:3007415 ! APH(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "APH(6)-Ia" EXACT CARD_Short_Name [] synonym: "aphD" EXACT [] [Term] id: ARO:3002658 name: APH(6)-Ib namespace: antibiotic_resistance def: "APH(6)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. glaucescens." [PMID:3039305] is_a: ARO:3007415 ! APH(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "APH(6)-Ib" EXACT CARD_Short_Name [] synonym: "sph" EXACT [] [Term] id: ARO:3002659 name: APH(6)-Ic namespace: antibiotic_resistance def: "APH(6)-Ic is a transposon-encoded aminoglycoside phosphotransferase in S. enterica, P. aeruginosa and E. coli." [PMID:15102449, PMID:3889831] is_a: ARO:3007415 ! APH(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "APH(6)-Ic" EXACT CARD_Short_Name [] synonym: "sph" EXACT [] synonym: "str" EXACT [] [Term] id: ARO:3002660 name: APH(6)-Id namespace: antibiotic_resistance def: "APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum." [PMID:18413319, PMID:2653965, PMID:15722395, PMID:19465049] is_a: ARO:3007415 ! APH(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "APH(6)-Id" EXACT CARD_Short_Name [] synonym: "strB, orfI" EXACT [] [Term] id: ARO:3002661 name: APH(7'')-Ia namespace: antibiotic_resistance def: "APH(7'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. hygroscopicus." [PMID:12627869] is_a: ARO:3007417 ! APH(7'')-I relationship: confers_resistance_to_antibiotic ARO:3000214 ! hygromycin B synonym: "APH(7'')-Ia" EXACT CARD_Short_Name [] [Term] id: ARO:3002662 name: APH(9)-Ia namespace: antibiotic_resistance def: "APH(9)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in L. pneumophila." [PMID:9174205] is_a: ARO:3007416 ! APH(9)-I relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "APH(9)-Ia" EXACT CARD_Short_Name [] xref: PDB:3I0O [Term] id: ARO:3002663 name: APH(9)-Ib namespace: antibiotic_resistance def: "APH(9)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. flavopersicus." [PMID:9245803] is_a: ARO:3007416 ! APH(9)-I relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "APH(9)-Ib" EXACT CARD_Short_Name [] synonym: "spcN" EXACT [] [Term] id: ARO:3002665 name: npmA namespace: antibiotic_resistance def: "NpmA is a plasmid-mediated aminoglycoside-resistance 16S rRNA methyltransferase by interfering with aminoglycoside binding with the A site of 16S rRNA through N-1 methylation at position A1408." [PMID:17875999] is_a: ARO:3004272 ! 16S rRNA methyltransferase (A1408) relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000021 ! ribostamycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "npmA" EXACT CARD_Short_Name [] [Term] id: ARO:3002666 name: rmtF namespace: antibiotic_resistance def: "RmtF is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides." [PMID:26488937, PMID:22547620] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000003 ! astromicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "rmtF" EXACT CARD_Short_Name [] [Term] id: ARO:3002667 name: rmtD namespace: antibiotic_resistance def: "RmtD is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides." [PMID:18222955, PMID:17158944] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "rmtD" EXACT CARD_Short_Name [] [Term] id: ARO:3002668 name: rmtG namespace: antibiotic_resistance def: "RmtG is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides." [PMID:23459483] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "rmtG" EXACT CARD_Short_Name [] [Term] id: ARO:3002669 name: APH(2'')-Ig namespace: antibiotic_resistance def: "APH('')-Ig is a plasmid-encoded aminoglycoside phosphotransferase in Campylobacter coli." [PMID:23959310] is_a: ARO:3000128 ! APH(2'') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "APH(2'')-Ig" EXACT CARD_Short_Name [] [Term] id: ARO:3002670 name: cat namespace: antibiotic_resistance def: "cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini." [PMID:2697637, PMID:12726767, PMID:12732947, PMID:12603745, PMID:11677608, PMID:1517170, PMID:2013403, PMID:9349809, PMID:6950931, PMID:11553538, PMID:1929326, PMID:2993795, PMID:11735367, PMID:11743194, PMID:1406372, PMID:1650008, PMID:3865770, PMID:1713259, PMID:1461942, PMID:19459958, PMID:2227449, PMID:3110008, PMID:3900035, PMID:1929282, PMID:3860383] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cat" EXACT CARD_Short_Name [] [Term] id: ARO:3002671 name: Limosilactobacillus reuteri cat-TC namespace: antibiotic_resistance def: "cat-TC is a plasmid-encoded variant of the cat gene found in Limosilactobacillus reuteri." [PMID:8954883] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "Lreu_cat-TC" EXACT CARD_Short_Name [] [Term] id: ARO:3002672 name: Bacillus pumilus cat86 namespace: antibiotic_resistance def: "cat86 is a chromosome-encoded variant of the cat gene found in Bacillus pumilus." [PMID:6315534] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "Bpum_cat86" EXACT CARD_Short_Name [] [Term] id: ARO:3002674 name: Clostridium butyricum catB namespace: antibiotic_resistance def: "catB is a chromosome-encoded variant of the cat gene found in Clostridium butyricum." [PMID:1489203] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "Cbut_catB" EXACT CARD_Short_Name [] [Term] id: ARO:3002675 name: catB2 namespace: antibiotic_resistance def: "catB2 is a plasmid-encoded variant of the cat gene found in Escherichia coli, Salmonella enteritidis and Pasteurella multocida." [PMID:12089302, PMID:1314803, PMID:19719593] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catB2" EXACT CARD_Short_Name [] [Term] id: ARO:3002676 name: catB3 namespace: antibiotic_resistance def: "catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli." [PMID:12654674, PMID:12821475, PMID:7793874, PMID:9835490] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catB3" EXACT CARD_Short_Name [] synonym: "catB4" EXACT [] [Term] id: ARO:3002678 name: Pseudomonas aeruginosa catB6 namespace: antibiotic_resistance def: "catB6 is a plasmid-encoded variant of the cat gene found in Pseudomonas aeruginosa." [PMID:10103196] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "Paer_catB6" EXACT CARD_Short_Name [] [Term] id: ARO:3002679 name: Pseudomonas aeruginosa catB7 namespace: antibiotic_resistance def: "catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa." [PMID:10361706, PMID:10984043] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "Paer_catB7" EXACT CARD_Short_Name [] [Term] id: ARO:3002680 name: catB8 namespace: antibiotic_resistance def: "catB8 is a plasmid or integron-encoded variant of the cat gene found in Klebsiella pneumoniae, Salmonella typhi and Pseudomonas aeruginosa." [PMID:12760886] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catB8" EXACT CARD_Short_Name [] [Term] id: ARO:3002681 name: catB9 namespace: antibiotic_resistance def: "catB9 is a chromosome-encoded variant of the cat gene found in Vibrio cholerae." [PMID:11952913, PMID:10952301] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catB9" EXACT CARD_Short_Name [] [Term] id: ARO:3002682 name: catD namespace: antibiotic_resistance def: "catD is a chromosome and transposon-encoded variant of the cat gene found in Clostridioides difficile." [PMID:11069682] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catD" EXACT CARD_Short_Name [] [Term] id: ARO:3002683 name: catA1 namespace: antibiotic_resistance def: "catA1 (formerly in CARD as catI) is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii." [PMID:390403, PMID:1650008] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "cat1" EXACT [] synonym: "catA1" EXACT CARD_Short_Name [] synonym: "catI" EXACT [] [Term] id: ARO:3002684 name: catII namespace: antibiotic_resistance def: "catII is a plasmid-encoded variant of the cat gene found in Haemophilus influenzae, Agrobacterium tumefaciens and Escherichia coli." [PMID:2268278] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catII" EXACT CARD_Short_Name [] [Term] id: ARO:3002685 name: catIII namespace: antibiotic_resistance def: "catIII is a plasmid-encoded variant of the cat gene found in Shigella flexneri." [PMID:3048245] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catA3" EXACT [] synonym: "catIII" EXACT CARD_Short_Name [] [Term] id: ARO:3002686 name: catP namespace: antibiotic_resistance def: "catP is a transposon and chromosome-encoded variant of the cat gene found in Clostridium perfringens and Neisseria meningitidis." [PMID:9744970, PMID:7565113] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catP" EXACT CARD_Short_Name [] [Term] id: ARO:3002687 name: catQ namespace: antibiotic_resistance def: "catQ is a chromosome-encoded variant of the cat gene found in Clostridium perfringens." [PMID:2039197] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catQ" EXACT CARD_Short_Name [] [Term] id: ARO:3002688 name: catS namespace: antibiotic_resistance def: "catS is a chromosome-encoded variant of the cat gene found in Streptococcus pyogenes." [PMID:8109922] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catS" EXACT CARD_Short_Name [] [Term] id: ARO:3002689 name: Plasmid-encoded cat (pp-cat) namespace: antibiotic_resistance def: "Plasmid-encoded cat, or pp-cat, is a plasmid-encoded variant of the cat gene found in Photobacterium damselae subsp. piscicida." [PMID:8271973] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "pp_cat" EXACT CARD_Short_Name [] [Term] id: ARO:3002690 name: Streptomyces lividans cmlR namespace: antibiotic_resistance def: "cmlR is a plasmid or chromosome-encoded chloramphenicol resistance determinant (putative transmembrane protein) that is found in Escherichia coli and Streptomyces lividans." [PMID:1779766, PMID:3011609] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Sliv_cmlR" EXACT CARD_Short_Name [] [Term] id: ARO:3002691 name: Salmonella enterica cmlA namespace: antibiotic_resistance def: "cmlA is a plasmid-encoded chloramphenicol exporter that is found in Salmonella typhimurium." [PMID:11959555] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Sent_cmlA" EXACT CARD_Short_Name [] [Term] id: ARO:3002693 name: cmlA1 namespace: antibiotic_resistance def: "cmlA1 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa and Klebsiella pneumoniae." [PMID:11600350, PMID:12936998, PMID:1658833, PMID:1648560] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmlA1" EXACT CARD_Short_Name [] [Term] id: ARO:3002694 name: cmlA4 namespace: antibiotic_resistance def: "cmlA4 is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella pneumoniae." [PMID:10681329] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_drug_class ARO:3000387 ! phenicol antibiotic synonym: "cmlA4" EXACT CARD_Short_Name [] [Term] id: ARO:3002695 name: cmlA5 namespace: antibiotic_resistance def: "cmlA5 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Escherichia coli." [PMID:10049269, PMID:19719593] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmlA5" EXACT CARD_Short_Name [] synonym: "cmlA7" EXACT [] [Term] id: ARO:3002696 name: cmlA6 namespace: antibiotic_resistance def: "cmlA6 is a plasmid-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa." [PMID:11353602] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmlA6" EXACT CARD_Short_Name [] [Term] id: ARO:3002698 name: cmlB namespace: antibiotic_resistance def: "cmlB is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella aerogenes." [PMID:9756755] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmlA2" EXACT [] synonym: "cmlB" EXACT CARD_Short_Name [] [Term] id: ARO:3002699 name: cmlB1 namespace: antibiotic_resistance def: "cmlB1 is a plasmid-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica." [PMID:17224413] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmlB1" EXACT CARD_Short_Name [] [Term] id: ARO:3002700 name: cmlv namespace: antibiotic_resistance def: "cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae." [PMID:7592948] is_a: ARO:3000249 ! chloramphenicol phosphotransferase relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmlv" EXACT CARD_Short_Name [] xref: PDB:1QHN [Term] id: ARO:3002701 name: Rhodococcus fascians cmr namespace: antibiotic_resistance def: "cmr is a plasmid-encoded chloramphenicol exporter that is found in Rhodococcus fascians and Corynebacterium glutamicum." [PMID:1406276] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Rfas_cmr" EXACT CARD_Short_Name [] [Term] id: ARO:3002702 name: cmrA namespace: antibiotic_resistance def: "cmrA is a transposon-encoded chloramphenicol exporter that is found in Rhodococcus rhodochrous." [PMID:9226278] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmrA" EXACT CARD_Short_Name [] [Term] id: ARO:3002703 name: cmx namespace: antibiotic_resistance def: "cmx is a plasmid or transposon-encoded chloramphenicol exporter that is found in Corynebacterium striatum and Pseudomonas aeruginosa." [PMID:9735314, PMID:8834878] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmx" EXACT CARD_Short_Name [] [Term] id: ARO:3002704 name: fexA namespace: antibiotic_resistance def: "fexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus." [PMID:14742219] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol synonym: "fexA" EXACT CARD_Short_Name [] [Term] id: ARO:3002705 name: floR namespace: antibiotic_resistance def: "floR is a plasmid or chromosome-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 and Vibrio cholerae." [PMID:12493808, PMID:11544236, PMID:17224413, PMID:14645321, PMID:19292580, PMID:12107144, PMID:10991873, PMID:11101601, PMID:11451703, PMID:10339826, PMID:11600347] is_a: ARO:3003963 ! flo relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol synonym: "floR" EXACT CARD_Short_Name [] [Term] id: ARO:3002706 name: ethambutol resistant embC namespace: antibiotic_resistance def: "Mycobacterium tuberculosis embC mutations at codon 270 confer resistance to ethambutol." [PMID:19112008] is_a: ARO:3005005 ! antibiotic-resistant emb arabinosyltransferase relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic relationship: derives_from ARO:3000763 ! antibiotic sensitive embC [Term] id: ARO:3002707 name: QnrA1 namespace: antibiotic_resistance def: "QnrA1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae." [PMID:11943863] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrA1" EXACT CARD_Short_Name [] [Term] id: ARO:3002708 name: QnrA2 namespace: antibiotic_resistance def: "QnrA2 is a plasmid-mediated quinolone resistance protein found in Klebsiella oxytoca." [PMID:16020539] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrA2" EXACT CARD_Short_Name [] [Term] id: ARO:3002709 name: QnrA3 namespace: antibiotic_resistance def: "QnrA3 is a plasmid-mediated quinolone resistance protein found in Shewanella algae." [PMID:16048974] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrA3" EXACT CARD_Short_Name [] [Term] id: ARO:3002710 name: QnrA4 namespace: antibiotic_resistance def: "QnrA4 is a plasmid-mediated quinolone resistance protein found in Shewanella algae." [PMID:16048974] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrA4" EXACT CARD_Short_Name [] [Term] id: ARO:3002711 name: QnrA5 namespace: antibiotic_resistance def: "QnrA5 is a plasmid-mediated quinolone resistance protein found in Shewanella algae." [PMID:16048974] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrA5" EXACT CARD_Short_Name [] [Term] id: ARO:3002712 name: QnrA6 namespace: antibiotic_resistance def: "QnrA6 is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis." [PMID:16961639] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrA6" EXACT CARD_Short_Name [] [Term] id: ARO:3002713 name: QnrA7 namespace: antibiotic_resistance def: "QnrA7 is a plasmid-mediated quinolone resistance protein found in Shewanella algae." [PMID:34914577] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrA7" EXACT CARD_Short_Name [] [Term] id: ARO:3002714 name: QnrB1 namespace: antibiotic_resistance def: "QnrB1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae." [PMID:16569827] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB1" EXACT CARD_Short_Name [] [Term] id: ARO:3002715 name: QnrB2 namespace: antibiotic_resistance def: "QnrB2 is a plasmid-mediated quinolone resistance protein found in Citrobacter koseri." [PMID:16569827] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB2" EXACT CARD_Short_Name [] [Term] id: ARO:3002716 name: QnrB3 namespace: antibiotic_resistance def: "QnrB3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:16870791] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB3" EXACT CARD_Short_Name [] [Term] id: ARO:3002718 name: QnrB4 namespace: antibiotic_resistance def: "QnrB4 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:16870791] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB4" EXACT CARD_Short_Name [] [Term] id: ARO:3002719 name: QnrB5 namespace: antibiotic_resistance def: "QnrB5 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica." [PMID:16804843] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB5" EXACT CARD_Short_Name [] [Term] id: ARO:3002720 name: QnrB6 namespace: antibiotic_resistance def: "QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans." [PMID:19392890] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB6" EXACT CARD_Short_Name [] [Term] id: ARO:3002721 name: QnrB7 namespace: antibiotic_resistance def: "QnrB7 is a plasmid-mediated quinolone resistance protein found in Enterobacter cloacae." [PMID:17561500] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB7" EXACT CARD_Short_Name [] [Term] id: ARO:3002722 name: QnrB8 namespace: antibiotic_resistance def: "QnrB8 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:17561500] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB8" EXACT CARD_Short_Name [] [Term] id: ARO:3002723 name: QnrB9 namespace: antibiotic_resistance def: "QnrB9 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:24093472] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB9" EXACT CARD_Short_Name [] [Term] id: ARO:3002724 name: QnrB10 namespace: antibiotic_resistance def: "QnrB10 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:17938184] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB10" EXACT CARD_Short_Name [] [Term] id: ARO:3002725 name: QnrB11 namespace: antibiotic_resistance def: "QnrB11 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:18426894] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB11" EXACT CARD_Short_Name [] [Term] id: ARO:3002726 name: QnrB12 namespace: antibiotic_resistance def: "QnrB12 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii." [PMID:18086833] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB12" EXACT CARD_Short_Name [] [Term] id: ARO:3002727 name: QnrB13 namespace: antibiotic_resistance def: "QnrB13 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:18725444] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB13" EXACT CARD_Short_Name [] [Term] id: ARO:3002728 name: QnrB14 namespace: antibiotic_resistance def: "QnrB14 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:18725444] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB14" EXACT CARD_Short_Name [] [Term] id: ARO:3002730 name: QnrB15 namespace: antibiotic_resistance def: "QnrB15 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:18725444] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB15" EXACT CARD_Short_Name [] [Term] id: ARO:3002731 name: QnrB16 namespace: antibiotic_resistance def: "QnrB16 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:19392890] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB16" EXACT CARD_Short_Name [] [Term] id: ARO:3002732 name: QnrB17 namespace: antibiotic_resistance def: "QnrB17 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:22850691] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB17" EXACT CARD_Short_Name [] [Term] id: ARO:3002733 name: QnrB18 namespace: antibiotic_resistance def: "QnrB18 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:22731858] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB18" EXACT CARD_Short_Name [] [Term] id: ARO:3002734 name: QnrB19 namespace: antibiotic_resistance def: "QnrB19 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:18519717] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB19" EXACT CARD_Short_Name [] [Term] id: ARO:3002735 name: QnrB20 namespace: antibiotic_resistance def: "QnrB20 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:18993034] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB20" EXACT CARD_Short_Name [] [Term] id: ARO:3002736 name: QnrB21 namespace: antibiotic_resistance def: "QnrB21 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:18426894] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB21" EXACT CARD_Short_Name [] [Term] id: ARO:3002737 name: QnrB22 namespace: antibiotic_resistance def: "QnrB22 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii." [PMID:20421404] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB22" EXACT CARD_Short_Name [] [Term] id: ARO:3002738 name: QnrB23 namespace: antibiotic_resistance def: "QnrB23 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:20421404] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB23" EXACT CARD_Short_Name [] [Term] id: ARO:3002739 name: QnrB24 namespace: antibiotic_resistance def: "QnrB24 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21816943] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB24" EXACT CARD_Short_Name [] [Term] id: ARO:3002740 name: QnrB25 namespace: antibiotic_resistance def: "QnrB25 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:22850691] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB25" EXACT CARD_Short_Name [] [Term] id: ARO:3002741 name: QnrB26 namespace: antibiotic_resistance def: "QnrB26 is a plasmid-mediated quinolone resistance protein found in Proteus vulgaris." [PMID:23844849] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB26" EXACT CARD_Short_Name [] [Term] id: ARO:3002742 name: QnrB27 namespace: antibiotic_resistance def: "QnrB27 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii." [PMID:21830908] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB27" EXACT CARD_Short_Name [] [Term] id: ARO:3002743 name: QnrB28 namespace: antibiotic_resistance def: "QnrB28 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21830908] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB28" EXACT CARD_Short_Name [] [Term] id: ARO:3002744 name: QnrB29 namespace: antibiotic_resistance def: "QnrB29 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21830908] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB29" EXACT CARD_Short_Name [] [Term] id: ARO:3002745 name: QnrB30 namespace: antibiotic_resistance def: "QnrB30 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii." [PMID:21830908] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB30" EXACT CARD_Short_Name [] [Term] id: ARO:3002746 name: QnrB31 namespace: antibiotic_resistance def: "QnrB31 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae." [PMID:21816942] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB31" EXACT CARD_Short_Name [] [Term] id: ARO:3002747 name: QnrB32 namespace: antibiotic_resistance def: "QnrB32 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21844311] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB32" EXACT CARD_Short_Name [] [Term] id: ARO:3002748 name: QnrB33 namespace: antibiotic_resistance def: "QnrB33 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii." [PMID:21844311] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB33" EXACT CARD_Short_Name [] [Term] id: ARO:3002749 name: QnrB34 namespace: antibiotic_resistance def: "QnrB34 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii." [PMID:21844311] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB34" EXACT CARD_Short_Name [] [Term] id: ARO:3002750 name: QnrB35 namespace: antibiotic_resistance def: "QnrB35 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21844311] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB35" EXACT CARD_Short_Name [] [Term] id: ARO:3002751 name: QnrB36 namespace: antibiotic_resistance def: "QnrB36 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21844311] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB36" EXACT CARD_Short_Name [] [Term] id: ARO:3002752 name: QnrB37 namespace: antibiotic_resistance def: "QnrB37 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21844311] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB37" EXACT CARD_Short_Name [] [Term] id: ARO:3002753 name: QnrB38 namespace: antibiotic_resistance def: "QnrB38 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21844311] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB38" EXACT CARD_Short_Name [] [Term] id: ARO:3002754 name: QnrB39 namespace: antibiotic_resistance def: "QnrB39 is a chromosome-mediated quinolone resistance protein found in Citrobacter youngae." [PMID:21844311] is_a: ARO:3000419 ! quinolone resistance protein (qnr) synonym: "QnrB39" EXACT CARD_Short_Name [] [Term] id: ARO:3002755 name: QnrB40 namespace: antibiotic_resistance def: "QnrB40 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii." [PMID:21830908] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB40" EXACT CARD_Short_Name [] [Term] id: ARO:3002756 name: QnrB41 namespace: antibiotic_resistance def: "QnrB41 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:21830908] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB41" EXACT CARD_Short_Name [] [Term] id: ARO:3002757 name: QnrB42 namespace: antibiotic_resistance def: "QnrB42 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae." [PMID:22850691] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB42" EXACT CARD_Short_Name [] [Term] id: ARO:3002758 name: QnrB43 namespace: antibiotic_resistance def: "QnrB43 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:23162539] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB43" EXACT CARD_Short_Name [] [Term] id: ARO:3002759 name: QnrB44 namespace: antibiotic_resistance def: "QnrB44 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:26207437] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB44" EXACT CARD_Short_Name [] [Term] id: ARO:3002760 name: QnrB45 namespace: antibiotic_resistance def: "QnrB45 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:23162539] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB45" EXACT CARD_Short_Name [] [Term] id: ARO:3002761 name: QnrB46 namespace: antibiotic_resistance def: "QnrB46 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:21816942] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB46" EXACT CARD_Short_Name [] synonym: "QnrB53" EXACT [] [Term] id: ARO:3002762 name: QnrB47 namespace: antibiotic_resistance def: "QnrB47 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB47" EXACT CARD_Short_Name [] synonym: "QnrB51" EXACT [] [Term] id: ARO:3002763 name: QnrB48 namespace: antibiotic_resistance def: "QnrB48 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:23162539] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB48" EXACT CARD_Short_Name [] [Term] id: ARO:3002764 name: QnrB49 namespace: antibiotic_resistance def: "QnrB49 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:22731858] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB49" EXACT CARD_Short_Name [] [Term] id: ARO:3002765 name: QnrB50 namespace: antibiotic_resistance def: "QnrB50 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:23162539] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB50" EXACT CARD_Short_Name [] [Term] id: ARO:3002767 name: QnrB54 namespace: antibiotic_resistance def: "QnrB54 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:25512409] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB54" EXACT CARD_Short_Name [] [Term] id: ARO:3002768 name: QnrB55 namespace: antibiotic_resistance def: "QnrB55 is a plasmid-mediated quinolone resistance protein found in Raoultella terrigena." [PMID:27192164] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB55" EXACT CARD_Short_Name [] [Term] id: ARO:3002769 name: QnrB56 namespace: antibiotic_resistance def: "QnrB56 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:26169406] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB56" EXACT CARD_Short_Name [] [Term] id: ARO:3002770 name: QnrB57 namespace: antibiotic_resistance def: "QnrB57 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:26169406] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB57" EXACT CARD_Short_Name [] [Term] id: ARO:3002771 name: QnrB58 namespace: antibiotic_resistance def: "QnrB58 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:26169406] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB58" EXACT CARD_Short_Name [] [Term] id: ARO:3002772 name: QnrB59 namespace: antibiotic_resistance def: "QnrB59 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:18426894] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB59" EXACT CARD_Short_Name [] [Term] id: ARO:3002773 name: QnrB60 namespace: antibiotic_resistance def: "QnrB60 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:23529729] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB60" EXACT CARD_Short_Name [] [Term] id: ARO:3002774 name: QnrB61 namespace: antibiotic_resistance def: "QnrB61 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii." [PMID:23529729] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB61" EXACT CARD_Short_Name [] [Term] id: ARO:3002775 name: QnrB62 namespace: antibiotic_resistance def: "QnrB62 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:27572415] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB62" EXACT CARD_Short_Name [] [Term] id: ARO:3002776 name: QnrB64 namespace: antibiotic_resistance def: "QnrB64 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB64" EXACT CARD_Short_Name [] [Term] id: ARO:3002777 name: QnrB65 namespace: antibiotic_resistance def: "QnrB65 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB65" EXACT CARD_Short_Name [] [Term] id: ARO:3002778 name: QnrB66 namespace: antibiotic_resistance def: "QnrB66 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB66" EXACT CARD_Short_Name [] [Term] id: ARO:3002779 name: QnrB67 namespace: antibiotic_resistance def: "QnrB67 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB67" EXACT CARD_Short_Name [] [Term] id: ARO:3002780 name: QnrB68 namespace: antibiotic_resistance def: "QnrB68 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB68" EXACT CARD_Short_Name [] [Term] id: ARO:3002781 name: QnrB69 namespace: antibiotic_resistance def: "QnrB69 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB69" EXACT CARD_Short_Name [] [Term] id: ARO:3002782 name: QnrB70 namespace: antibiotic_resistance def: "QnrB70 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB70" EXACT CARD_Short_Name [] [Term] id: ARO:3002783 name: QnrB71 namespace: antibiotic_resistance def: "QnrB71 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii." [PMID:24247140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB71" EXACT CARD_Short_Name [] [Term] id: ARO:3002784 name: QnrB72 namespace: antibiotic_resistance def: "QnrB72 is a plasmid-mediated quinolone resistance protein found in Citrobacter sp. TR21_24." [PMID:26169406] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB72" EXACT CARD_Short_Name [] [Term] id: ARO:3002785 name: QnrB73 namespace: antibiotic_resistance def: "QnrB73 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii." [PMID:26169406] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB73" EXACT CARD_Short_Name [] [Term] id: ARO:3002786 name: QnrB74 namespace: antibiotic_resistance def: "QnrB74 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:26259681] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrB74" EXACT CARD_Short_Name [] [Term] id: ARO:3002787 name: QnrC namespace: antibiotic_resistance def: "QnrC is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis." [PMID:19258263] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrC" EXACT CARD_Short_Name [] [Term] id: ARO:3002788 name: QnrD1 namespace: antibiotic_resistance def: "QnrD1 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica." [PMID:19029321] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrD1" EXACT CARD_Short_Name [] [Term] id: ARO:3002789 name: QnrD2 namespace: antibiotic_resistance def: "QnrD2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica." [PMID:24733466] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrD2" EXACT CARD_Short_Name [] [Term] id: ARO:3002790 name: QnrS1 namespace: antibiotic_resistance def: "QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri." [PMID:15673773] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS1" EXACT CARD_Short_Name [] [Term] id: ARO:3002791 name: QnrS2 namespace: antibiotic_resistance def: "QnrS2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica." [PMID:16804843] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS2" EXACT CARD_Short_Name [] [Term] id: ARO:3002792 name: QnrS3 namespace: antibiotic_resistance def: "QnrS3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [PMID:18573620] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS3" EXACT CARD_Short_Name [] [Term] id: ARO:3002793 name: QnrS4 namespace: antibiotic_resistance def: "QnrS4 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica." [PMID:19056747] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS4" EXACT CARD_Short_Name [] [Term] id: ARO:3002794 name: QnrS5 namespace: antibiotic_resistance def: "QnrS5 is a plasmid-mediated quinolone resistance protein found in Aeromonas sobria." [PMID:22024339] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS5" EXACT CARD_Short_Name [] [Term] id: ARO:3002795 name: QnrS6 namespace: antibiotic_resistance def: "QnrS6 is a plasmid-mediated quinolone resistance protein found in Aeromonas hydrophila." [PMID:22024339] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS6" EXACT CARD_Short_Name [] [Term] id: ARO:3002796 name: QnrS7 namespace: antibiotic_resistance def: "QnrS7 is a plasmid-mediated quinolone resistance protein found in Escherichia coli." [] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS7" EXACT CARD_Short_Name [] [Term] id: ARO:3002797 name: QnrS8 namespace: antibiotic_resistance def: "QnrS8 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae." [PMID:26618005] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS8" EXACT CARD_Short_Name [] [Term] id: ARO:3002798 name: QnrS9 namespace: antibiotic_resistance def: "QnrS9 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae." [PMID:24458509] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS9" EXACT CARD_Short_Name [] [Term] id: ARO:3002799 name: QnrVC1 namespace: antibiotic_resistance def: "QnrVC1 is an integron-mediated quinolone resistance protein found in Vibrio cholerae." [PMID:18598639] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrVC1" EXACT CARD_Short_Name [] [Term] id: ARO:3002800 name: QnrVC3 namespace: antibiotic_resistance def: "QnrVC3 is an integron-mediated quinolone resistance protein found in Vibrio cholerae." [PMID:20516288] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrVC3" EXACT CARD_Short_Name [] [Term] id: ARO:3002801 name: QnrVC4 namespace: antibiotic_resistance def: "QnrVC4 is an integron-mediated quinolone resistance protein found in Aeromonas punctata." [PMID:23098826] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrVC4" EXACT CARD_Short_Name [] [Term] id: ARO:3002802 name: QnrVC5 namespace: antibiotic_resistance def: "QnrVC5 is an integron-mediated quinolone resistance protein found in Vibrio fluvialis." [PMID:23800600] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrVC5" EXACT CARD_Short_Name [] [Term] id: ARO:3002803 name: QnrVC6 namespace: antibiotic_resistance def: "QnrVC6 is an integron-mediated quinolone resistance protein found in Acinetobacter baumannii." [PMID:23800600] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrVC6" EXACT CARD_Short_Name [] [Term] id: ARO:3002804 name: FosA2 namespace: antibiotic_resistance def: "An enzyme that confers resistance to fosfomycin in Enterobacter cloacae by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule." [PMID:21392044] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosA2" EXACT CARD_Short_Name [] [Term] id: ARO:3002811 name: antibiotic-resistant murA transferase namespace: antibiotic_resistance def: "murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance." [PMID:20071153] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007149 ! phosphonic acid antibiotic relationship: derives_from ARO:3000724 ! fosfomycin sensitive pyruvyl transferase (murA) [Term] id: ARO:3002812 name: pp-flo namespace: antibiotic_resistance def: "pp-flo is a plasmid chloramphenicol exporter that is found in Photobacterium damselae subsp. piscicida." [PMID:8908612] is_a: ARO:3003963 ! flo relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol synonym: "pp-flo" EXACT CARD_Short_Name [] [Term] id: ARO:3002813 name: lmrB namespace: antibiotic_resistance def: "lmrB is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Bacillus subtilis." [PMID:15317768] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: part_of ARO:3003027 ! lmrAB Operon synonym: "lmrB" EXACT CARD_Short_Name [] [Term] id: ARO:3002814 name: clbA namespace: antibiotic_resistance def: "clbA is a plasmid-encoded cfr gene found in Bacillus velezensis (Bacillus amyloliquefaciens subsp. plantarum)." [PMID:22547628] is_a: ARO:3004607 ! Cfr Group relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin synonym: "clbA" EXACT CARD_Short_Name [] [Term] id: ARO:3002815 name: clbB namespace: antibiotic_resistance def: "clbB is a plasmid-encoded cfr gene found in Bacillus brevis." [PMID:29259290, PMID:22547628] is_a: ARO:3004609 ! cfr(B) Group relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin synonym: "clbB" EXACT CARD_Short_Name [] [Term] id: ARO:3002816 name: clbC namespace: antibiotic_resistance def: "clbC is a plasmid-encoded cfr gene found in Alkalihalobacillus clausii." [PMID:22547628] is_a: ARO:3004607 ! Cfr Group relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin synonym: "clbC" EXACT CARD_Short_Name [] [Term] id: ARO:3002817 name: carA namespace: antibiotic_resistance def: "carA is an ABC-F subfamily protein involved in macrolide resistance. It is found in Streptomyces thermotolerans." [PMID:1612454] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:3001228 ! carbomycin synonym: "carA" EXACT CARD_Short_Name [] [Term] id: ARO:3002818 name: msrB namespace: antibiotic_resistance def: "MsrB is an ABC-F subfamily protein expressed to Staphylococcus species that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA." [PMID:1426997] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin synonym: "msr(B)" EXACT [] synonym: "msrB" EXACT CARD_Short_Name [] [Term] id: ARO:3002819 name: msrC namespace: antibiotic_resistance def: "msrC is a chromosomal-encoded ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to erythromycin and other macrolide and streptogramin B antibiotics." [PMID:11120975] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin synonym: "msr(C)" EXACT [] synonym: "msrC" EXACT CARD_Short_Name [] [Term] id: ARO:3002823 name: ErmH namespace: antibiotic_resistance def: "ErmH is a plasmid-mediated methyltransferase found in Streptomyces thermotolerans." [PMID:3036668] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin relationship: confers_resistance_to_antibiotic ARO:3001228 ! carbomycin synonym: "ErmH" EXACT CARD_Short_Name [] synonym: "carB" EXACT [] [Term] id: ARO:3002824 name: ErmV namespace: antibiotic_resistance def: "ErmV is a plasmid-mediated methyltransferase found in Streptomyces viridochromogenes." [PMID:9055987, PMID:6163765] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin relationship: confers_resistance_to_antibiotic ARO:3001222 ! chalcomycin relationship: confers_resistance_to_antibiotic ARO:3001227 ! kitasamycin relationship: confers_resistance_to_antibiotic ARO:3001228 ! carbomycin relationship: confers_resistance_to_antibiotic ARO:3001231 ! celesticetin synonym: "ErmV" EXACT CARD_Short_Name [] synonym: "ermSV" EXACT [] [Term] id: ARO:3002825 name: ErmY namespace: antibiotic_resistance def: "ErmY is a plasmid-mediated methyltransferase found in Staphylococcus aureus." [PMID:9809423] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "ErmGM" EXACT [] synonym: "ErmY" EXACT CARD_Short_Name [] [Term] id: ARO:3002826 name: EreA2 namespace: antibiotic_resistance def: "EreA2 is an integron-encoded erythromycin esterase that hydrolyses the drug's lactone ring. EreA2 is found in Providencia stuartii." [PMID:12654734] is_a: ARO:3000320 ! macrolide esterase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Ere(A2)" EXACT [] synonym: "EreA2" EXACT CARD_Short_Name [] [Term] id: ARO:3002827 name: tlrC namespace: antibiotic_resistance def: "tlrC is an ABC-F subfamily protein found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. tlrC is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide." [PMID:1864505] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3001224 ! mycinamicin synonym: "tlrC" EXACT CARD_Short_Name [] [Term] id: ARO:3002828 name: srmB namespace: antibiotic_resistance def: "srmB is an ABC-F subfamily protein found in Streptomyces ambofaciens that confers resistance to spiramycin." [PMID:1612454] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin synonym: "srmB" EXACT CARD_Short_Name [] [Term] id: ARO:3002829 name: vgaA namespace: antibiotic_resistance def: "vgaA is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA." [PMID:23796922] is_a: ARO:3000113 ! vga-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "vgaA" EXACT CARD_Short_Name [] [Term] id: ARO:3002830 name: vgaALC namespace: antibiotic_resistance def: "vgaALC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA." [PMID:17015629] is_a: ARO:3000113 ! vga-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "vgaALC" EXACT CARD_Short_Name [] [Term] id: ARO:3002831 name: vgaC namespace: antibiotic_resistance def: "vgaC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA." [PMID:20876620, PMID:19470508] is_a: ARO:3000113 ! vga-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3001315 ! valnemulin synonym: "vgaC" EXACT CARD_Short_Name [] [Term] id: ARO:3002832 name: vgaD namespace: antibiotic_resistance def: "vgaD is an ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA." [PMID:20713681] is_a: ARO:3000113 ! vga-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin synonym: "vgaD" EXACT CARD_Short_Name [] [Term] id: ARO:3002833 name: vgaE namespace: antibiotic_resistance def: "vgaE is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with transposon DNA." [PMID:21768510] is_a: ARO:3000113 ! vga-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin synonym: "vgaE" EXACT CARD_Short_Name [] [Term] id: ARO:3002835 name: lnuA namespace: antibiotic_resistance def: "lnuA is a plasmid-mediated nucleotidyltransferase found in Staphylococcus chromogenes." [PMID:17329268] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3007169 ! pirlimycin synonym: "linA" EXACT [] synonym: "lnuA" EXACT CARD_Short_Name [] [Term] id: ARO:3002836 name: lnuB namespace: antibiotic_resistance def: "lnuB is a plasmid-mediated nucleotidyltransferase found in Streptococcus lutetiensis." [PMID:10103201, PMID:24048528] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "linB" EXACT [] synonym: "lnuB" EXACT CARD_Short_Name [] [Term] id: ARO:3002837 name: lnuC namespace: antibiotic_resistance def: "lnuC is a transposon-mediated nucleotidyltransferase found in Streptococcus agalactiae." [PMID:15980341] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin synonym: "linC" EXACT [] synonym: "lnuC" EXACT CARD_Short_Name [] [Term] id: ARO:3002838 name: lnuD namespace: antibiotic_resistance def: "lnuD is a plasmid-mediated nucleotidyltransferase found in Streptococcus uberis." [PMID:18086844] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "linD" EXACT [] synonym: "lnuD" EXACT CARD_Short_Name [] [Term] id: ARO:3002839 name: lnuF namespace: antibiotic_resistance def: "lnuF is an integron-mediated nucleotidyltransferase found in Escherichia coli." [PMID:15242512] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "linF" EXACT [] synonym: "lnuF" EXACT CARD_Short_Name [] [Term] id: ARO:3002840 name: vatA namespace: antibiotic_resistance def: "vatA is a plasmid-mediated acetyltransferase found in Staphylococcus aureus." [PMID:8344533] is_a: ARO:3000453 ! streptogramin vat acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "vat(A)" EXACT [] synonym: "vatA" EXACT CARD_Short_Name [] [Term] id: ARO:3002841 name: vatB namespace: antibiotic_resistance def: "vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus." [PMID:8540711] is_a: ARO:3000453 ! streptogramin vat acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "vat(B)" EXACT [] synonym: "vatB" EXACT CARD_Short_Name [] [Term] id: ARO:3002842 name: vatC namespace: antibiotic_resistance def: "vatC is a plasmid-mediated acetyltransferase found in Staphylococcus cohnii." [PMID:9661023] is_a: ARO:3000453 ! streptogramin vat acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "vat(C)" EXACT [] synonym: "vatC" EXACT CARD_Short_Name [] [Term] id: ARO:3002843 name: vatD namespace: antibiotic_resistance def: "vatD is a transposon-mediated acetyltransferase found in Enterococcus faecium." [PMID:11600385] is_a: ARO:3000453 ! streptogramin vat acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "vat(D)" EXACT [] synonym: "vatD" EXACT CARD_Short_Name [] [Term] id: ARO:3002844 name: vatE namespace: antibiotic_resistance def: "vatE is a transposon-mediated acetyltransferase found in Enterococcus faecium." [PMID:11023445] is_a: ARO:3000453 ! streptogramin vat acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "satG" EXACT [] synonym: "vat(E)" EXACT [] synonym: "vatE" EXACT CARD_Short_Name [] [Term] id: ARO:3002845 name: vatH namespace: antibiotic_resistance def: "vatH is a plasmid-mediated acetyltransferase found in Enterococcus faecium." [PMID:20713681] is_a: ARO:3000453 ! streptogramin vat acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "vatG" EXACT [] synonym: "vatH" EXACT CARD_Short_Name [] [Term] id: ARO:3002846 name: arr-1 namespace: antibiotic_resistance def: "arr-1 is a chromosome-encoded ribosyltransferase found in Mycolicibacterium smegmatis." [PMID:9371349] is_a: ARO:3000390 ! rifampin ADP-ribosyltransferase (Arr) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "arr-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002847 name: arr-2 namespace: antibiotic_resistance def: "arr-2 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa." [PMID:10103210] is_a: ARO:3000390 ! rifampin ADP-ribosyltransferase (Arr) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "arr-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002848 name: arr-3 namespace: antibiotic_resistance def: "arr-3 is a plasmid-encoded ribosyltransferase found in Vibrio fluvialis." [PMID:21683552] is_a: ARO:3000390 ! rifampin ADP-ribosyltransferase (Arr) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "arr-3" EXACT CARD_Short_Name [] synonym: "arr-6" EXACT [] [Term] id: ARO:3002849 name: arr-4 namespace: antibiotic_resistance def: "arr-4 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa." [PMID:18299416] is_a: ARO:3000390 ! rifampin ADP-ribosyltransferase (Arr) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "arr-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002850 name: arr-5 namespace: antibiotic_resistance def: "arr-5 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa." [PMID:18299416] is_a: ARO:3000390 ! rifampin ADP-ribosyltransferase (Arr) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "arr-5" EXACT CARD_Short_Name [] [Term] id: ARO:3002852 name: arr-7 namespace: antibiotic_resistance def: "arr-7 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa." [PMID:19884381] is_a: ARO:3000390 ! rifampin ADP-ribosyltransferase (Arr) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "arr-7" EXACT CARD_Short_Name [] [Term] id: ARO:3002853 name: arr-8 namespace: antibiotic_resistance def: "arr-8 is an integron-encoded ribosyltransferase found in Klebsiella oxytoca." [PMID:23752512] is_a: ARO:3000390 ! rifampin ADP-ribosyltransferase (Arr) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "arr-8" EXACT CARD_Short_Name [] [Term] id: ARO:3002854 name: dfrA1 namespace: antibiotic_resistance def: "dfrA1 is an integron-encoded dihydrofolate reductase." [PMID:15388464] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfr1" EXACT [] synonym: "dfrA1" EXACT CARD_Short_Name [] synonym: "dhfrI" EXACT [] [Term] id: ARO:3002856 name: dfrA24 namespace: antibiotic_resistance def: "dfrA24 is an integron-encoded dihydrofolate reductase found in Escherichia coli." [PMID:17307981] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA24" EXACT CARD_Short_Name [] [Term] id: ARO:3002857 name: dfrA26 namespace: antibiotic_resistance def: "dfrA26 is an integron-encoded dihydrofolate reductase found in Escherichia coli." [PMID:17307981] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA26" EXACT CARD_Short_Name [] [Term] id: ARO:3002858 name: dfrA12 namespace: antibiotic_resistance def: "dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae." [PMID:20660690, PMID:12183252] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA12" EXACT CARD_Short_Name [] [Term] id: ARO:3002859 name: dfrA14 namespace: antibiotic_resistance def: "dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli." [PMID:18794381] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA14" EXACT CARD_Short_Name [] [Term] id: ARO:3002860 name: dfrA17 namespace: antibiotic_resistance def: "dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli." [PMID:20236427] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA17" EXACT CARD_Short_Name [] [Term] id: ARO:3002861 name: dfrA5 namespace: antibiotic_resistance def: "dfrA5 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae." [PMID:12183252] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA5" EXACT CARD_Short_Name [] [Term] id: ARO:3002862 name: dfrA7 namespace: antibiotic_resistance def: "dfrA7 is an integron-encoded dihydrofolate reductase found in Escherichia coli." [PMID:19229487] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA7" EXACT CARD_Short_Name [] [Term] id: ARO:3002863 name: dfrA8 namespace: antibiotic_resistance def: "dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica." [PMID:32849452] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA8" EXACT CARD_Short_Name [] synonym: "dhfrIIIc" EXACT [] [Term] id: ARO:3002864 name: dfrB1 namespace: antibiotic_resistance def: "A plasmid-associated trimethoprim-resistant dihydrofolate reductase detected in Bordetella bronchispetica on pKBB958." [PMID:16046466] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfr2a" EXACT [] synonym: "dfrB1" EXACT CARD_Short_Name [] synonym: "dfrII" EXACT [] [Term] id: ARO:3002865 name: dfrC namespace: antibiotic_resistance def: "dfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus." [PMID:7768789] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrC" EXACT CARD_Short_Name [] [Term] id: ARO:3002866 name: dfrD namespace: antibiotic_resistance def: "dfrD is a plasmid-encoded dihydrofolate reductase found in Listeria monocytogenes." [PMID:9145882] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrD" EXACT CARD_Short_Name [] [Term] id: ARO:3002867 name: dfrF namespace: antibiotic_resistance def: "dfrF is a chromosome-encoded dihydrofolate reductase found in Streptococcus pyogenes." [PMID:24492367] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrF" EXACT CARD_Short_Name [] [Term] id: ARO:3002868 name: dfrG namespace: antibiotic_resistance def: "dfrG is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus." [PMID:16127079] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrG" EXACT CARD_Short_Name [] [Term] id: ARO:3002869 name: dfrK namespace: antibiotic_resistance def: "dfrK is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus." [PMID:22718530] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrK" EXACT CARD_Short_Name [] [Term] id: ARO:3002870 name: tet(34) namespace: antibiotic_resistance def: "tet(34) causes the activation of Mg2+-dependent purine nucleotide synthesis, which protects the protein synthesis pathway. It is found in Gram-negative Vibrio." [PMID:11959596] is_a: ARO:3000012 ! protein(s) conferring antibiotic resistance via molecular bypass is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(34)" EXACT CARD_Short_Name [] synonym: "tet34" EXACT [] [Term] id: ARO:3002871 name: tet(37) namespace: antibiotic_resistance def: "tet(37) is a chromosome-encoded oxidoreductase isolated from an uncultured bacterium that confers resistance to tetracycline." [PMID:12654685] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(37)" EXACT CARD_Short_Name [] synonym: "tet37" EXACT [] [Term] id: ARO:3002872 name: FosA3 namespace: antibiotic_resistance def: "An enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule." [PMID:26488485] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosA3" EXACT CARD_Short_Name [] [Term] id: ARO:3002873 name: FosB3 namespace: antibiotic_resistance def: "A thiol transferase that leads to the resistance of fosfomycin in Enterococcus faecium. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol to open up the epoxide ring of fosfomycin." [PMID:24205114] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosB3" EXACT CARD_Short_Name [] [Term] id: ARO:3002874 name: FosC2 namespace: antibiotic_resistance def: "FosC2 is an enzyme that phosphorylates fosfomycin to confer resistance in Escherichia coli." [PMID:20404116] is_a: ARO:3004245 ! fosC phosphotransferase family relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosC2" EXACT CARD_Short_Name [] [Term] id: ARO:3002875 name: dfrE namespace: antibiotic_resistance def: "dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis." [PMID:9869579] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrE" EXACT CARD_Short_Name [] [Term] id: ARO:3002876 name: ethambutol resistant aftA namespace: antibiotic_resistance def: "Arabinofuranosyltransferases allow for the polymerization of arabinose to form arabinan. Arabinan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to ethambutol." [] is_a: ARO:3003422 ! antibiotic resistant aftA relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic relationship: derives_from ARO:3000725 ! antibiotic sensitive aftA [Term] id: ARO:3002877 name: BcI namespace: antibiotic_resistance def: "Bacillus cereus beta-lactamase I is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9." [PMID:29551437] is_a: ARO:3007100 ! class A Bacillus cereus Bc beta-lactamase synonym: "BcI" EXACT CARD_Short_Name [] [Term] id: ARO:3002878 name: BcII namespace: antibiotic_resistance def: "Bacillus cereus beta-lactamase II is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 5/B/6." [PMID:7588620] is_a: ARO:3000577 ! subclass B1 Bacillus cereus Bc beta-lactamase synonym: "BcII" EXACT CARD_Short_Name [] [Term] id: ARO:3002879 name: linG namespace: antibiotic_resistance def: "linG is an integron-associated gene cassette, with aadA2, encoding a lincosomide nucleotidyltransferase found in Salmonella enterica. linG confers resistance to lincosomide antibiotics." [PMID:17005845] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin synonym: "linG" EXACT CARD_Short_Name [] [Term] id: ARO:3002881 name: lmrC namespace: antibiotic_resistance def: "lmrC is an ABC-F subfamily protein that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD." [PMID:16958846] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3001231 ! celesticetin synonym: "lmrC" EXACT CARD_Short_Name [] synonym: "ydaG" EXACT [] [Term] id: ARO:3002882 name: lmrD namespace: antibiotic_resistance def: "lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC." [PMID:16958846] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic synonym: "lmrD" EXACT CARD_Short_Name [] synonym: "ydbA" EXACT [] [Term] id: ARO:3002883 name: rgt1438 namespace: antibiotic_resistance def: "rgt1438 is a glycosyltransferase that confers rifampin resistance in Streptomyces." [PMID:22802246] is_a: ARO:3000443 ! rifampin glycosyltransferase relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "rgt1438" EXACT CARD_Short_Name [] [Term] id: ARO:3002884 name: iri namespace: antibiotic_resistance def: "iri is a monooxygenase that confers resistance to rifampin found in Rhodococcus hoagii." [PMID:8980786] is_a: ARO:3000445 ! rifampin monooxygenase relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "iri" EXACT CARD_Short_Name [] [Term] id: ARO:3002891 name: Streptomyces rimosus otr(A) namespace: antibiotic_resistance def: "Streptomyces rimosus otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus." [PMID:1809836] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "otr(A)S.rim" EXACT CARD_Short_Name [] [Term] id: ARO:3002892 name: otr(B) namespace: antibiotic_resistance def: "otr(B) is a tetracycline resistance efflux pump found in Streptomyces rimosus." [PMID:9867793] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "otr(B)" EXACT CARD_Short_Name [] synonym: "otrB" EXACT [] synonym: "tet347" EXACT [] [Term] id: ARO:3002893 name: tcr3 namespace: antibiotic_resistance def: "tcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens." [PMID:8534971] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tcr3" EXACT CARD_Short_Name [] synonym: "trcC" EXACT [] [Term] id: ARO:3002894 name: otr(C) namespace: antibiotic_resistance def: "otr(C) is a tetracycline resistance efflux pump found in Streptomyces rimosus." [PMID:22906146] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "otr(C)" EXACT CARD_Short_Name [] synonym: "otrC" EXACT [] [Term] id: ARO:3002895 name: SAT-2 namespace: antibiotic_resistance def: "SAT-2 is a plasmid-mediated streptothricin acetyltransferase, which confers resistance to streptothricin, a nucleoside antibiotic. Originally described from an E. coli plasmid sequence by Heim et al., 1989." [PMID:2157196, PMID:2550905] is_a: ARO:3000869 ! streptothricin acetyltransferase (SAT) relationship: confers_resistance_to_antibiotic ARO:0000012 ! streptothricin synonym: "SAT-2" EXACT CARD_Short_Name [] [Term] id: ARO:3002897 name: SAT-4 namespace: antibiotic_resistance def: "SAT-4 is a plasmid-mediated streptothricin acetyltransferase and streptothricin (a nucleoside antibiotic) resistant determinant. Originally described from a Campylobacter coli BE/G4 plasmid gene sequence by Jacob et al, 1994." [PMID:8056285] is_a: ARO:3000869 ! streptothricin acetyltransferase (SAT) relationship: confers_resistance_to_antibiotic ARO:0000012 ! streptothricin synonym: "SAT-4" EXACT CARD_Short_Name [] [Term] id: ARO:3002898 name: SAT-3 namespace: antibiotic_resistance def: "SAT-3 is a plasmid-mediated streptothricin acetyltransferase and streptothricin resistance determinant. Originally described from an E. coli plasmid gene by Tietze and Brevet, 1995." [PMID:7640311] is_a: ARO:3000869 ! streptothricin acetyltransferase (SAT) relationship: confers_resistance_to_antibiotic ARO:0000012 ! streptothricin synonym: "SAT-3" EXACT CARD_Short_Name [] [Term] id: ARO:3002905 name: VanS-VanR two-component regulatory system namespace: antibiotic_resistance def: "These genes are involved in activating and regulating transcription of gene clusters." [PMID:1556077] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster [Term] id: ARO:3002906 name: Van ligase namespace: antibiotic_resistance def: "Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity." [PMID:12019119, PMID:16723588, PMID:24342631, PMID:15980329, PMID:21807981, PMID:18458129, PMID:16323116, PMID:20733041] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3002907 name: vanE namespace: antibiotic_resistance def: "VanE is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis." [PMID:12019119] is_a: ARO:3002979 ! D-Ala-D-Ser ligase relationship: part_of ARO:3000259 ! glycopeptide resistance gene cluster VanE synonym: "vanE" EXACT CARD_Short_Name [] [Term] id: ARO:3002908 name: vanF namespace: antibiotic_resistance def: "VanF is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance in Paenibacillus popilliae." [PMID:15980329] is_a: ARO:3002978 ! D-Ala-D-Lac ligase relationship: part_of ARO:3000255 ! glycopeptide resistance gene cluster VanF synonym: "vanF" EXACT CARD_Short_Name [] [Term] id: ARO:3002909 name: vanG namespace: antibiotic_resistance def: "VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis." [PMID:12426332, PMID:16323116] is_a: ARO:3002979 ! D-Ala-D-Ser ligase relationship: part_of ARO:3000257 ! glycopeptide resistance gene cluster VanG synonym: "vanG" EXACT CARD_Short_Name [] [Term] id: ARO:3002910 name: vanL namespace: antibiotic_resistance def: "VanL is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis." [PMID:18458129] is_a: ARO:3002979 ! D-Ala-D-Ser ligase relationship: part_of ARO:3000260 ! glycopeptide resistance gene cluster VanL synonym: "vanL" EXACT CARD_Short_Name [] [Term] id: ARO:3002911 name: vanM namespace: antibiotic_resistance def: "VanM is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance." [PMID:20733041] is_a: ARO:3002978 ! D-Ala-D-Lac ligase relationship: part_of ARO:3000256 ! glycopeptide resistance gene cluster VanM synonym: "vanM" EXACT CARD_Short_Name [] [Term] id: ARO:3002912 name: vanN namespace: antibiotic_resistance def: "VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecium." [PMID:21807981] is_a: ARO:3002979 ! D-Ala-D-Ser ligase relationship: part_of ARO:3002917 ! glycopeptide resistance gene cluster VanN synonym: "vanN" EXACT CARD_Short_Name [] [Term] id: ARO:3002913 name: vanO namespace: antibiotic_resistance def: "VanO is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance." [PMID:24342631] is_a: ARO:3002978 ! D-Ala-D-Lac ligase relationship: part_of ARO:3002918 ! glycopeptide resistance gene cluster VanO synonym: "vanO" EXACT CARD_Short_Name [] [Term] id: ARO:3002914 name: vanJ namespace: antibiotic_resistance def: "vanJ is a novel membrane protein that confers resistance to teicoplanin and its derivatives in Streptomyces coelicolor by recycling undecaprenol pyrophosphate during cell wall biosynthesis." [PMID:22232274, PMID:15130128] is_a: ARO:3004255 ! vanJ membrane protein relationship: confers_resistance_to_antibiotic ARO:0000029 ! teicoplanin synonym: "vanJ" EXACT CARD_Short_Name [] [Term] id: ARO:3002915 name: vanK namespace: antibiotic_resistance def: "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance." [PMID:15632111, PMID:15130128] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3002916 name: vanV namespace: antibiotic_resistance def: "vanV is an accessory protein of van operons, first identified in the vanB operon. It is not required for vancomycin resistance." [PMID:21482081] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3002917 name: glycopeptide resistance gene cluster VanN namespace: antibiotic_resistance def: "Homologous to vanC, contains a D-Ala-D-Ser ligase. The plasmid-located vanM gene cluster is inducible and confers low resistance to vancomycin. vanN organisms remain susceptible to teicoplanin. Gene orientation: N(XY)TRS." [PMID:21807981] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "vanN_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3002918 name: glycopeptide resistance gene cluster VanO namespace: antibiotic_resistance def: "Homologous to vanA, contains a D-Ala-D-Lac ligase. The chromosome-located vanO gene cluster is inducible. Not much is known about the biochemistry about the vanO gene cluster. Gene orientation: orf1 RS orf2 HOX." [PMID:24342631] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "vanO_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3002919 name: vanR gene in vanA cluster namespace: antibiotic_resistance def: "Also known as vanRA, is a vanR variant found in the vanA gene cluster." [PMID:8380148, PMID:16323116] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000236 ! glycopeptide resistance gene cluster VanA synonym: "vanR-A" EXACT [] synonym: "vanRA" EXACT [] synonym: "vanR_in_vanA_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002921 name: vanR gene in vanB cluster namespace: antibiotic_resistance def: "Also known as vanRB, is a vanR variant found in the vanB gene cluster." [PMID:8631706, PMID:16323116] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000238 ! glycopeptide resistance gene cluster VanB synonym: "vanR-B" EXACT [] synonym: "vanRB" EXACT [] synonym: "vanR_in_vanB_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002922 name: vanR gene in vanC cluster namespace: antibiotic_resistance def: "Also known as vanRC, is a vanR variant found in the vanC gene cluster." [PMID:10817725, PMID:16323116] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000246 ! glycopeptide resistance gene cluster VanC synonym: "vanR-C" EXACT [] synonym: "vanRC" EXACT [] synonym: "vanR_in_vanC_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002923 name: vanR gene in vanD cluster namespace: antibiotic_resistance def: "Also known as vanRD, is a mutated vanR variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis." [PMID:12499162, PMID:16323116] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000253 ! glycopeptide resistance gene cluster VanD synonym: "vanR-D" EXACT [] synonym: "vanRD" EXACT [] synonym: "vanR_in_vanD_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002924 name: vanR gene in vanE cluster namespace: antibiotic_resistance def: "Also known as vanRE, is a vanR variant found in the vanE gene cluster." [PMID:12019119] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000259 ! glycopeptide resistance gene cluster VanE synonym: "vanR-E" EXACT [] synonym: "vanRE" EXACT [] synonym: "vanR_in_vanE_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002925 name: vanR gene in vanF cluster namespace: antibiotic_resistance def: "Also known as vanRF, is a vanR variant found in the vanF gene cluster." [PMID:15980329] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000255 ! glycopeptide resistance gene cluster VanF synonym: "vanR-F" EXACT [] synonym: "vanRF" EXACT [] synonym: "vanR_in_vanF_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002926 name: vanR gene in vanG cluster namespace: antibiotic_resistance def: "Also known as vanRG, is a vanR variant found in the vanG gene cluster." [PMID:16723588] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000257 ! glycopeptide resistance gene cluster VanG synonym: "vanR-G" EXACT [] synonym: "vanRG" EXACT [] synonym: "vanR_in_vanG_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002927 name: vanR gene in vanL cluster namespace: antibiotic_resistance def: "Also known as vanRL, is a vanR variant found in the vanL gene cluster." [PMID:18458129] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000260 ! glycopeptide resistance gene cluster VanL synonym: "vanR-L" EXACT [] synonym: "vanRL" EXACT [] synonym: "vanR_in_vanL_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002928 name: vanR gene in vanM cluster namespace: antibiotic_resistance def: "Also known as vanRM, is a vanR variant found in the vanM gene cluster." [PMID:20733041] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3000256 ! glycopeptide resistance gene cluster VanM synonym: "vanR-M" EXACT [] synonym: "vanRM" EXACT [] synonym: "vanR_in_vanM_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002929 name: vanR gene in vanN cluster namespace: antibiotic_resistance def: "Also known as vanRN, is a vanR variant found in the vanN gene cluster." [PMID:21807981] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3002917 ! glycopeptide resistance gene cluster VanN synonym: "vanR-N" EXACT [] synonym: "vanRN" EXACT [] synonym: "vanR_in_vanN_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002930 name: vanR gene in vanO cluster namespace: antibiotic_resistance def: "Also known as vanRO, is a vanR variant found in the vanO gene cluster." [PMID:24342631] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3002918 ! glycopeptide resistance gene cluster VanO synonym: "vanR-O" EXACT [] synonym: "vanRO" EXACT [] synonym: "vanR_in_vanO_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002931 name: vanS gene in vanA cluster namespace: antibiotic_resistance def: "Also known as vanSA, is a vanS variant found in the vanA gene cluster." [PMID:8380148, PMID:16323116, PMID:28511809] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000236 ! glycopeptide resistance gene cluster VanA synonym: "vanS-A" EXACT [] synonym: "vanSA" EXACT [] synonym: "vanS_in_vanA_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002932 name: vanS gene in vanB cluster namespace: antibiotic_resistance def: "Also known as vanSB, is a vanS variant found in the vanB gene cluster." [PMID:8631706, PMID:16323116] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000238 ! glycopeptide resistance gene cluster VanB synonym: "vanS-B" EXACT [] synonym: "vanSB" EXACT [] synonym: "vanS_in_vanB_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002933 name: vanS gene in vanC cluster namespace: antibiotic_resistance def: "Also known as vanSC, is a vanS variant found in the vanC gene cluster." [PMID:10817725, PMID:16323116] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000246 ! glycopeptide resistance gene cluster VanC synonym: "vanS-C" EXACT [] synonym: "vanSC" EXACT [] synonym: "vanS_in_vanC_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002934 name: vanS gene in vanD cluster namespace: antibiotic_resistance def: "Also known as vanSD, is a mutated vanS variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis." [PMID:19258279, PMID:16323116] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000253 ! glycopeptide resistance gene cluster VanD synonym: "vanS-D" EXACT [] synonym: "vanSD" EXACT [] synonym: "vanS_in_vanD_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002935 name: vanS gene in vanE cluster namespace: antibiotic_resistance def: "Also known as vanSE, is a vanS variant found in the vanE gene cluster." [PMID:12019119] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000259 ! glycopeptide resistance gene cluster VanE synonym: "vanS-E" EXACT [] synonym: "vanSE" EXACT [] synonym: "vanS_in_vanE_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002936 name: vanS gene in vanF cluster namespace: antibiotic_resistance def: "Also known as vanSF, is a vanS variant found in the vanF gene cluster." [PMID:15980329] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000255 ! glycopeptide resistance gene cluster VanF synonym: "vanS-F" EXACT [] synonym: "vanSF" EXACT [] synonym: "vanS_in_vanF_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002937 name: vanS gene in vanG cluster namespace: antibiotic_resistance def: "Also known as vanSG, is a vanS variant found in the vanG gene cluster." [PMID:16723588] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000257 ! glycopeptide resistance gene cluster VanG synonym: "vanS-G" EXACT [] synonym: "vanSG" EXACT [] synonym: "vanS_in_vanG_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002938 name: vanS gene in vanL cluster namespace: antibiotic_resistance def: "Also known as vanSL, is a vanS variant found in the vanL gene cluster." [PMID:18458129] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000260 ! glycopeptide resistance gene cluster VanL synonym: "vanS-L" EXACT [] synonym: "vanSL" EXACT [] synonym: "vanS_in_vanL_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002939 name: vanS gene in vanM cluster namespace: antibiotic_resistance def: "Also known as vanSM, is a vanS variant found in the vanM gene cluster." [PMID:20733041] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3000256 ! glycopeptide resistance gene cluster VanM synonym: "vanS-M" EXACT [] synonym: "vanSM" EXACT [] synonym: "vanS_in_vanM_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002940 name: vanS gene in vanN cluster namespace: antibiotic_resistance def: "Also known as vanSN, is a vanS variant found in the vanN gene cluster." [PMID:21807981] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3002917 ! glycopeptide resistance gene cluster VanN synonym: "vanS-N" EXACT [] synonym: "vanSN" EXACT [] synonym: "vanS_in_vanN_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002941 name: vanS gene in vanO cluster namespace: antibiotic_resistance def: "Also known as vanSO, is a vanS variant found in the vanO gene cluster." [PMID:24342631] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3002918 ! glycopeptide resistance gene cluster VanO synonym: "vanS-O" EXACT [] synonym: "vanSO" EXACT [] synonym: "vanS_in_vanO_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002942 name: vanH gene in vanA cluster namespace: antibiotic_resistance def: "Also known as vanHA, is a vanH variant in the vanA gene cluster." [PMID:16323116, PMID:8380148] is_a: ARO:3000006 ! vanH relationship: part_of ARO:3000236 ! glycopeptide resistance gene cluster VanA synonym: "vanH-A" EXACT [] synonym: "vanHA" EXACT [] synonym: "vanH_in_vanA_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002943 name: vanH gene in vanB cluster namespace: antibiotic_resistance def: "Also known as vanHB, is a vanH variant in the vanB gene cluster." [PMID:16323116, PMID:8631706] is_a: ARO:3000006 ! vanH relationship: part_of ARO:3000238 ! glycopeptide resistance gene cluster VanB synonym: "vanH-B" EXACT [] synonym: "vanHB" EXACT [] synonym: "vanH_in_vanB_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002944 name: vanH gene in vanD cluster namespace: antibiotic_resistance def: "Also known as vanHD, is a vanH variant in the vanD gene cluster." [PMID:12499162, PMID:16323116] is_a: ARO:3000006 ! vanH relationship: part_of ARO:3000253 ! glycopeptide resistance gene cluster VanD synonym: "vanH-D" EXACT [] synonym: "vanHD" EXACT [] synonym: "vanH_in_vanD_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002945 name: vanH gene in vanF cluster namespace: antibiotic_resistance def: "Also known as vanHF, is a vanH variant in the vanF gene cluster." [PMID:15980329] is_a: ARO:3000006 ! vanH relationship: part_of ARO:3000255 ! glycopeptide resistance gene cluster VanF synonym: "vanH-F" EXACT [] synonym: "vanHF" EXACT [] synonym: "vanH_in_vanF_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002947 name: vanH gene in vanM cluster namespace: antibiotic_resistance def: "Also known as vanHM, is a vanH variant in the vanM gene cluster." [PMID:20733041] is_a: ARO:3000006 ! vanH relationship: part_of ARO:3000256 ! glycopeptide resistance gene cluster VanM synonym: "vanH-M" EXACT [] synonym: "vanHM" EXACT [] synonym: "vanH_in_vanM_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002948 name: vanH gene in vanO cluster namespace: antibiotic_resistance def: "Also known as vanHO, is a vanH variant in the vanO gene cluster." [PMID:24342631] is_a: ARO:3000006 ! vanH relationship: part_of ARO:3002918 ! glycopeptide resistance gene cluster VanO synonym: "vanH-O" EXACT [] synonym: "vanHO" EXACT [] synonym: "vanH_in_vanO_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002949 name: vanX gene in vanA cluster namespace: antibiotic_resistance def: "Also known as vanXA, is a vanX variant found in the vanA gene cluster." [PMID:8380148, PMID:16323116] is_a: ARO:3000011 ! vanX relationship: part_of ARO:3000236 ! glycopeptide resistance gene cluster VanA synonym: "vanX-A" EXACT [] synonym: "vanXA" EXACT [] synonym: "vanX_in_vanA_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002950 name: vanX gene in vanB cluster namespace: antibiotic_resistance def: "Also known as vanXB, is a vanX variant found in the vanB gene cluster." [PMID:16323116, PMID:8631706] is_a: ARO:3000011 ! vanX relationship: part_of ARO:3000238 ! glycopeptide resistance gene cluster VanB synonym: "vanX-B" EXACT [] synonym: "vanXB" EXACT [] synonym: "vanX_in_vanB_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002952 name: vanX gene in vanF cluster namespace: antibiotic_resistance def: "Also known as vanXF, is a vanX variant found in the vanF gene cluster." [PMID:15980329] is_a: ARO:3000011 ! vanX relationship: part_of ARO:3000255 ! glycopeptide resistance gene cluster VanF synonym: "vanX-F" EXACT [] synonym: "vanXF" EXACT [] synonym: "vanX_in_vanF_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002953 name: vanX gene in vanM cluster namespace: antibiotic_resistance def: "Also known as vanXM, is a vanX variant found in the vanM gene cluster." [PMID:20733041] is_a: ARO:3000011 ! vanX relationship: part_of ARO:3000256 ! glycopeptide resistance gene cluster VanM synonym: "vanX-M" EXACT [] synonym: "vanXM" EXACT [] synonym: "vanX_in_vanM_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002954 name: vanX gene in vanO cluster namespace: antibiotic_resistance def: "Also known as vanXO, is a vanX variant found in the vanO gene cluster." [PMID:24342631] is_a: ARO:3000011 ! vanX relationship: part_of ARO:3002918 ! glycopeptide resistance gene cluster VanO synonym: "vanX-O" EXACT [] synonym: "vanXO" EXACT [] synonym: "vanX_in_vanO_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002955 name: vanY gene in vanA cluster namespace: antibiotic_resistance def: "Also known as vanYA, is a vanY variant found in the vanA gene cluster." [PMID:8380148, PMID:16323116] is_a: ARO:3000077 ! vanY relationship: part_of ARO:3000236 ! glycopeptide resistance gene cluster VanA synonym: "vanY-A" EXACT [] synonym: "vanYA" EXACT [] synonym: "vanY_in_vanA_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002956 name: vanY gene in vanB cluster namespace: antibiotic_resistance def: "Also known as vanYB, is a vanY variant found in the vanB gene cluster." [PMID:16323116, PMID:8631706] is_a: ARO:3000077 ! vanY relationship: part_of ARO:3000238 ! glycopeptide resistance gene cluster VanB synonym: "vanY-B" EXACT [] synonym: "vanYB" EXACT [] synonym: "vanY_in_vanB_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002957 name: vanY gene in vanD cluster namespace: antibiotic_resistance def: "Also known as vanYD, is a vanY variant found in the vanD gene cluster." [PMID:16323116, PMID:12499162] is_a: ARO:3000077 ! vanY relationship: part_of ARO:3000253 ! glycopeptide resistance gene cluster VanD synonym: "vanY-D" EXACT [] synonym: "vanYD" EXACT [] synonym: "vanY_in_vanD_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002958 name: vanY gene in vanF cluster namespace: antibiotic_resistance def: "Also known as vanYF, is a vanY variant found in the vanF gene cluster." [PMID:15980329] is_a: ARO:3000077 ! vanY relationship: part_of ARO:3000255 ! glycopeptide resistance gene cluster VanF synonym: "vanY-F" EXACT [] synonym: "vanYF" EXACT [] synonym: "vanY_in_vanF_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002959 name: vanY gene in vanG cluster namespace: antibiotic_resistance def: "Also known as vanYG, is a vanY variant found in the vanG gene cluster." [PMID:16723588] is_a: ARO:3000077 ! vanY relationship: part_of ARO:3000257 ! glycopeptide resistance gene cluster VanG synonym: "vanY-G" EXACT [] synonym: "vanYG" EXACT [] synonym: "vanYG1" EXACT [] synonym: "vanY_in_vanG_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002961 name: vanY gene in vanM cluster namespace: antibiotic_resistance def: "Also known as vanYM, is a vanY variant found in the vanM gene cluster." [PMID:20733041] is_a: ARO:3000077 ! vanY relationship: part_of ARO:3000256 ! glycopeptide resistance gene cluster VanM synonym: "vanY-M" EXACT [] synonym: "vanYM" EXACT [] synonym: "vanY_in_vanM_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002962 name: vanZ gene in vanA cluster namespace: antibiotic_resistance def: "Also known as vanZA, is a vanZ variant found in the vanA gene cluster." [PMID:16323116, PMID:7867956, PMID:8380148] is_a: ARO:3000116 ! vanZ relationship: part_of ARO:3000236 ! glycopeptide resistance gene cluster VanA synonym: "vanZ-A" EXACT [] synonym: "vanZA" EXACT [] synonym: "vanZ_in_vanA_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002963 name: vanZ gene in vanF cluster namespace: antibiotic_resistance def: "Also known as vanZF, is a vanZ variant found in the vanF gene cluster." [PMID:15980329] is_a: ARO:3000116 ! vanZ relationship: part_of ARO:3000255 ! glycopeptide resistance gene cluster VanF synonym: "vanZ-F" EXACT [] synonym: "vanZF" EXACT [] synonym: "vanZ_in_vanF_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002964 name: vanW gene in vanB cluster namespace: antibiotic_resistance def: "Also known as vanWB, is a vanW variant found in the vanB gene cluster." [PMID:8631706, PMID:16323116] is_a: ARO:3000002 ! vanW relationship: part_of ARO:3000238 ! glycopeptide resistance gene cluster VanB synonym: "vanW-B" EXACT [] synonym: "vanWB" EXACT [] synonym: "vanW_in_vanB_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002965 name: vanW gene in vanG cluster namespace: antibiotic_resistance def: "Also known as vanWG, is a vanW variant found in the vanG gene cluster." [PMID:16723588] is_a: ARO:3000002 ! vanW relationship: part_of ARO:3000257 ! glycopeptide resistance gene cluster VanG synonym: "vanW-G" EXACT [] synonym: "vanWG" EXACT [] synonym: "vanW_in_vanG_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002966 name: vanXY gene in vanC cluster namespace: antibiotic_resistance def: "Also known as vanXYC, is a vanXY variant found in the vanC gene cluster." [PMID:10564477, PMID:16323116] is_a: ARO:3000496 ! vanXY relationship: part_of ARO:3000246 ! glycopeptide resistance gene cluster VanC synonym: "vanXY-C" EXACT [] synonym: "vanXYC" EXACT [] synonym: "vanXY_in_vanC" EXACT CARD_Short_Name [] [Term] id: ARO:3002967 name: vanXY gene in vanE cluster namespace: antibiotic_resistance def: "Also known as vanXY, is a vanXY variant found in the vanE gene cluster." [PMID:12019119] is_a: ARO:3000496 ! vanXY relationship: part_of ARO:3000259 ! glycopeptide resistance gene cluster VanE synonym: "vanXY-E" EXACT [] synonym: "vanXYE" EXACT [] synonym: "vanXY_in_vanE" EXACT CARD_Short_Name [] [Term] id: ARO:3002968 name: vanXY gene in vanL cluster namespace: antibiotic_resistance def: "Also known as vanXYL, is a vanXY variant found in the vanL gene cluster." [PMID:18458129] is_a: ARO:3000496 ! vanXY relationship: part_of ARO:3000260 ! glycopeptide resistance gene cluster VanL synonym: "vanXY-L" EXACT [] synonym: "vanXYL" EXACT [] synonym: "vanXY_in_vanL" EXACT CARD_Short_Name [] [Term] id: ARO:3002969 name: vanXY gene in vanN cluster namespace: antibiotic_resistance def: "Also known as vanXYN, is a vanXY variant found in the vanN gene cluster." [PMID:21807981] is_a: ARO:3000496 ! vanXY relationship: part_of ARO:3002917 ! glycopeptide resistance gene cluster VanN synonym: "vanXY-N" EXACT [] synonym: "vanXYN" EXACT [] synonym: "vanXY_in_vanN" EXACT CARD_Short_Name [] [Term] id: ARO:3002970 name: vanT gene in vanC cluster namespace: antibiotic_resistance def: "Also known as vanTC, is a vanT variant found in the vanC gene cluster." [PMID:10209740, PMID:16323116] is_a: ARO:3000372 ! vanT relationship: part_of ARO:3000246 ! glycopeptide resistance gene cluster VanC synonym: "vanT-C" EXACT [] synonym: "vanTC" EXACT [] synonym: "vanT_in_vanC_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002971 name: vanT gene in vanE cluster namespace: antibiotic_resistance def: "Also known as vanTE, is a vanT variant found in the vanE gene cluster." [PMID:12019119] is_a: ARO:3000372 ! vanT relationship: part_of ARO:3000259 ! glycopeptide resistance gene cluster VanE synonym: "vanT-E" EXACT [] synonym: "vanTE" EXACT [] synonym: "vanT_in_vanE_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002972 name: vanT gene in vanG cluster namespace: antibiotic_resistance def: "Also known as vanTG, is a vanT variant found in the vanG gene cluster." [PMID:16723588] is_a: ARO:3000372 ! vanT relationship: part_of ARO:3000257 ! glycopeptide resistance gene cluster VanG synonym: "vanT-G" EXACT [] synonym: "vanTG" EXACT [] synonym: "vanT_in_vanG_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002973 name: vanTm gene in vanL cluster namespace: antibiotic_resistance def: "Also known as vanTmL, is a vanT variant found in the vanL gene cluster. vanTmL codes for the membrane-binding domain of vanTL." [PMID:18458129] is_a: ARO:3000372 ! vanT relationship: part_of ARO:3000260 ! glycopeptide resistance gene cluster VanL synonym: "vanTm-L" EXACT [] synonym: "vanTmL" EXACT [] synonym: "vanTm_in_vanL" EXACT CARD_Short_Name [] [Term] id: ARO:3002974 name: vanTr gene in vanL cluster namespace: antibiotic_resistance def: "Also known as vanTrL, is a vanT variant found in the vanL gene cluster. vanTrL codes for the racemase component of vanT." [PMID:18458129] is_a: ARO:3000372 ! vanT relationship: part_of ARO:3000260 ! glycopeptide resistance gene cluster VanL synonym: "vanTr-L" EXACT [] synonym: "vanTrL" EXACT [] synonym: "vanTr_in_vanL" EXACT CARD_Short_Name [] [Term] id: ARO:3002975 name: vanT gene in vanN cluster namespace: antibiotic_resistance def: "Also known as vanTN, is a vanT variant found in the vanN gene cluster." [PMID:21807981] is_a: ARO:3000372 ! vanT relationship: part_of ARO:3002917 ! glycopeptide resistance gene cluster VanN synonym: "vanT-N" EXACT [] synonym: "vanTN" EXACT [] synonym: "vanT_in_vanN_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3002976 name: gene(s) or protein(s) associated with a glycopeptide resistance cluster namespace: antibiotic_resistance def: "Van genes encode for various proteins that are involved in conferring vancomycin and teicoplanin resistance." [] is_a: ARO:3000012 ! protein(s) conferring antibiotic resistance via molecular bypass [Term] id: ARO:3002978 name: D-Ala-D-Lac ligase namespace: antibiotic_resistance def: "A van ligase that synthesizes D-Ala-D-Lac, an alternative peptidoglycan substrate that confers resistance to vancomycin." [PMID:24342631, PMID:15980329, PMID:16323116, PMID:20733041] is_a: ARO:3002906 ! Van ligase [Term] id: ARO:3002979 name: D-Ala-D-Ser ligase namespace: antibiotic_resistance def: "A van ligase that synthesizes D-Ala-D-Ser, an alternative peptidoglycan substrate that confers resistance to vancomycin." [PMID:16723588, PMID:22969085, PMID:12019119, PMID:16323116, PMID:18458129, PMID:21807981] is_a: ARO:3002906 ! Van ligase [Term] id: ARO:3002980 name: aspergillomarasmine A namespace: antibiotic_resistance def: "Aspergillomarasmine A, a fungal natural product, has been shown to inhibit the NDM-1 and VIM-2 enzymes, restoring of the activity of meropenem against carbapenem-resistant pathogens possessing either NDM-1 or VIM-2." [PMID:24965651, PMID:35155911] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002272 ! VIM-2 synonym: "BRN 2422056" EXACT [] synonym: "Toxin C" EXACT [] xref: pubchem.compound:197028 [Term] id: ARO:3002981 name: AmrAB-OprM namespace: antibiotic_resistance def: "AmrAB is an RND efflux system that impairs aminoglycoside accumulation in clinical Burkholderia vietnamiensis strains." [PMID:10582892, PMID:24393536] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3002982 name: amrA namespace: antibiotic_resistance def: "amrA is the efflux pump subunit of the AmrAB-OprM multidrug efflux complex. amrA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58." [PMID:10582892, PMID:24393536] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3002981 ! AmrAB-OprM synonym: "amrA" EXACT CARD_Short_Name [] [Term] id: ARO:3002983 name: amrB namespace: antibiotic_resistance def: "amrB is the membrane fusion protein of the AmrAB-OprM multidrug efflux complex." [PMID:24393536, PMID:10582892] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3002981 ! AmrAB-OprM synonym: "amrB" EXACT CARD_Short_Name [] [Term] id: ARO:3002985 name: arnA namespace: antibiotic_resistance def: "arnA modifies lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. arnA is found in E. coli and P. aeruginosa." [PMID:15939024, PMID:11021929] is_a: ARO:3004269 ! pmr phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B synonym: "PmrL" EXACT [] synonym: "arnA" EXACT CARD_Short_Name [] [Term] id: ARO:3002986 name: bacA namespace: antibiotic_resistance def: "The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin." [PMID:23460607] is_a: ARO:3003398 ! undecaprenyl pyrophosphate related proteins relationship: confers_resistance_to_antibiotic ARO:3000629 ! bacitracin A relationship: confers_resistance_to_antibiotic ARO:3000630 ! bacitracin B relationship: confers_resistance_to_antibiotic ARO:3000631 ! bacitracin F synonym: "bacA" EXACT CARD_Short_Name [] [Term] id: ARO:3002987 name: bcrA namespace: antibiotic_resistance def: "bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance." [PMID:7476193] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000629 ! bacitracin A relationship: confers_resistance_to_antibiotic ARO:3000630 ! bacitracin B relationship: confers_resistance_to_antibiotic ARO:3000631 ! bacitracin F synonym: "bcrA" EXACT CARD_Short_Name [] [Term] id: ARO:3002988 name: bcrB namespace: antibiotic_resistance def: "bcrB is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance." [PMID:7476193] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000629 ! bacitracin A relationship: confers_resistance_to_antibiotic ARO:3000630 ! bacitracin B relationship: confers_resistance_to_antibiotic ARO:3000631 ! bacitracin F synonym: "bcrB" EXACT CARD_Short_Name [] [Term] id: ARO:3002992 name: AQU beta-lactamase namespace: antibiotic_resistance def: "AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins." [PMID:24055254] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3002993 name: AQU-1 namespace: antibiotic_resistance def: "AQU-1 is a chromosomal class C beta-lactamase found in clinical Aeromonas dhakensis isolates." [PMID:24055254] is_a: ARO:3002992 ! AQU beta-lactamase synonym: "AQU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002994 name: ROB beta-lactamase namespace: antibiotic_resistance def: "ROB beta-lactamases are a class A beta-lactamases." [PMID:2201253] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3002995 name: ROB-1 namespace: antibiotic_resistance def: "ROB-1 is a beta-lactamase found in Pasteurella and Haemophilus." [PMID:17438055, PMID:2024956] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002996 name: LCR beta-lactamase namespace: antibiotic_resistance def: "LCR beta-lactamases are a class D beta-lactamase that hydrolyze a variety of penams and some cephalosporins." [] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3002997 name: LCR-1 namespace: antibiotic_resistance def: "LCR-1 is a class D beta-lactamase found in Pseudomonas aeruginosa." [PMID:1495394] is_a: ARO:3002996 ! LCR beta-lactamase synonym: "LCR-1" EXACT CARD_Short_Name [] [Term] id: ARO:3002998 name: CblA beta-lactamase namespace: antibiotic_resistance def: "CblA beta-lactamases are class A beta-lactamases that confer resistance to cephalosporins." [PMID:7985999] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3004129 ! cephaloridine relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3002999 name: CblA-1 namespace: antibiotic_resistance def: "CblA-1 beta-lactamase is a class A beta-lactamase found in Bacteroides uniformis that is species-specific." [PMID:7985999] is_a: ARO:3002998 ! CblA beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3004129 ! cephaloridine synonym: "CblA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003000 name: CfxA beta-lactamase namespace: antibiotic_resistance def: "CfxA beta-lactamases are class A beta-lactamases." [PMID:8517690] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin [Term] id: ARO:3003001 name: CfxA namespace: antibiotic_resistance def: "CfxA beta-lactamase is a class A beta-lactamase found in Bacteroides vulgatus." [PMID:8517690] is_a: ARO:3003000 ! CfxA beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:3004001 ! cefmetazole relationship: confers_resistance_to_antibiotic ARO:3004004 ! cefotetan relationship: confers_resistance_to_antibiotic ARO:3004014 ! flomoxef synonym: "CfxA" EXACT CARD_Short_Name [] [Term] id: ARO:3003002 name: CfxA2 namespace: antibiotic_resistance def: "CfxA2 beta-lactamase is a class A beta-lactamase found in Prevotella intermedia." [PMID:11451705] is_a: ARO:3003000 ! CfxA beta-lactamase synonym: "CfxA2" EXACT CARD_Short_Name [] [Term] id: ARO:3003003 name: CfxA3 namespace: antibiotic_resistance def: "CfxA3 beta-lactamase is a class A beta-lactamase found in Capnocytophaga ochracea." [PMID:14766881] is_a: ARO:3003000 ! CfxA beta-lactamase synonym: "CfxA3" EXACT CARD_Short_Name [] [Term] id: ARO:3003005 name: CfxA4 namespace: antibiotic_resistance def: "cfxA4 beta-lactamase is a class A beta-lactamase found in Bacteroides fragilis." [PMID:25460195] is_a: ARO:3003000 ! CfxA beta-lactamase synonym: "CfxA4" EXACT CARD_Short_Name [] [Term] id: ARO:3003006 name: blt namespace: antibiotic_resistance def: "blt is an MFS efflux pump that confers resistance to multiple drugs such as rhodamine and acridine dyes, and fluoroquinolone antibiotics." [PMID:7608059] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "blt" EXACT CARD_Short_Name [] [Term] id: ARO:3003007 name: bmr namespace: antibiotic_resistance def: "bmr is an MFS antibiotic efflux pump that confers resistance to multiple drugs including acridine dyes, fluoroquinolone antibiotics, chloramphenicol, and puromycin." [PMID:1675788, PMID:9079903] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000047 ! puromycin relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "bmr" EXACT CARD_Short_Name [] [Term] id: ARO:3003008 name: CeoAB-OpcM namespace: antibiotic_resistance def: "CeoAB is an RND efflux system that confers multidrug resistance in Burkholderia cenocepacia." [PMID:16857052] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3003009 name: ceoA namespace: antibiotic_resistance def: "ceoA is a periplasmic linker subunit of the CeoAB-OpcM efflux pump." [PMID:16857052] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003008 ! CeoAB-OpcM synonym: "ceoA" EXACT CARD_Short_Name [] [Term] id: ARO:3003010 name: ceoB namespace: antibiotic_resistance def: "ceoB is a cytoplasmic membrane component of the CeoAB-OpcM efflux pump." [PMID:16857052] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003008 ! CeoAB-OpcM synonym: "ceoB" EXACT CARD_Short_Name [] [Term] id: ARO:3003011 name: dfrA10 namespace: antibiotic_resistance def: "dfrA10 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae." [PMID:12499211] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA10" EXACT CARD_Short_Name [] [Term] id: ARO:3003012 name: dfrA13 namespace: antibiotic_resistance def: "dfrA13 is an integron-encoded dihydrofolate reductase found in Escherichia coli." [PMID:20374640, PMID:21237262, PMID:15140390] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA13" EXACT CARD_Short_Name [] [Term] id: ARO:3003013 name: dfrA15 namespace: antibiotic_resistance def: "dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae." [PMID:16980697] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA15" EXACT CARD_Short_Name [] [Term] id: ARO:3003014 name: dfrA16 namespace: antibiotic_resistance def: "dfrA16 is an integron-encoded dihydrofolate reductase found in Salmonella enterica." [PMID:17233727] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA16" EXACT CARD_Short_Name [] [Term] id: ARO:3003015 name: dfrA19 namespace: antibiotic_resistance def: "dfrA19 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae." [PMID:17368003] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA19" EXACT CARD_Short_Name [] [Term] id: ARO:3003016 name: dfrA20 namespace: antibiotic_resistance def: "dfrA20 is a plasmid-encoded dihydrofolate reductase found in Pasteurella multocida." [PMID:15616323] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA20" EXACT CARD_Short_Name [] [Term] id: ARO:3003017 name: dfrA21 namespace: antibiotic_resistance def: "dfrA21 is an integron-encoded dihydrofolate reductase found in Salmonella enterica." [PMID:15750057] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA21" EXACT CARD_Short_Name [] [Term] id: ARO:3003018 name: dfrA22 namespace: antibiotic_resistance def: "dfrA22 is an integron-encoded dihydrofolate reductase found in Salmonella enterica." [PMID:16782743, PMID:24152716] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA22" EXACT CARD_Short_Name [] [Term] id: ARO:3003019 name: dfrA23 namespace: antibiotic_resistance def: "dfrA23 is an integron-encoded dihydrofolate reductase found in Salmonella enterica." [PMID:15728925] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA23" EXACT CARD_Short_Name [] [Term] id: ARO:3003020 name: dfrA25 namespace: antibiotic_resistance def: "dfrA25 is an integron-encoded dihydrofolate reductase found in Salmonella agona." [PMID:16980698] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA25" EXACT CARD_Short_Name [] [Term] id: ARO:3003021 name: dfrB2 namespace: antibiotic_resistance def: "dfrB2 is an integron-encoded dihydrofolate reductase found in an uncultured bacterium from a wastewater treatment plant." [PMID:17261525, PMID:19719593] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrB2" EXACT CARD_Short_Name [] [Term] id: ARO:3003022 name: dfrB3 namespace: antibiotic_resistance def: "dfrB3 is an integron-encoded dihydrofolate reductase found in Klebsiella oxytoca." [PMID:22507248] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrB3" EXACT CARD_Short_Name [] [Term] id: ARO:3003023 name: dfrB6 namespace: antibiotic_resistance def: "dfrB6 is an integron-encoded dihydrofolate reductase found in Salmonella enterica." [PMID:16870788] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrB6" EXACT CARD_Short_Name [] [Term] id: ARO:3003025 name: fusidic acid inactivation enzyme namespace: antibiotic_resistance def: "Enzymes that confer resistance to fusidic acid by inactivation." [] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3007153 ! fusidane antibiotic relationship: participates_in ARO:3004140 ! hydrolysis of fusidic acid to inactive lactone derivative [Term] id: ARO:3003026 name: fusH namespace: antibiotic_resistance def: "fusH is a highly specific fusidic acid esterase found in Streptomyces lividans." [PMID:9084170] is_a: ARO:3003025 ! fusidic acid inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:3000759 ! fusidic acid synonym: "fusH" EXACT CARD_Short_Name [] [Term] id: ARO:3003027 name: lmrAB Operon namespace: antibiotic_resistance def: "lmrAB operon is involved in lincosamide resistance in Bacillus subtilis." [PMID:15317768] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000047 ! puromycin relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic [Term] id: ARO:3003028 name: lmrA namespace: antibiotic_resistance def: "lmrA is the repressor to the lmrAB operon in Bacillus subtilis. lmrA mutations result in lincomycin resistance." [PMID:9384377, PMID:15317768] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3003027 ! lmrAB Operon synonym: "lmrA" EXACT CARD_Short_Name [] [Term] id: ARO:3003029 name: MexVW-OprM namespace: antibiotic_resistance def: "MexVW-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexV is the membrane fusion protein; MexW is the RND-type membrane protein; and OprM is the outer membrane channel. MexVW-OprM is associated with resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin and acriflavine." [PMID:12951344] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "MexVW-OprM" EXACT CARD_Short_Name [] [Term] id: ARO:3003030 name: MexV namespace: antibiotic_resistance def: "MexV is the membrane fusion protein of the MexVW-OprM multidrug efflux complex." [PMID:12951344] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003029 ! MexVW-OprM synonym: "MexV" EXACT CARD_Short_Name [] [Term] id: ARO:3003031 name: MexW namespace: antibiotic_resistance def: "MexW is the RND-type membrane protein of the efflux complex MexVW-OprM." [PMID:12951344] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003029 ! MexVW-OprM synonym: "MexW" EXACT CARD_Short_Name [] [Term] id: ARO:3003032 name: MexXY-OprM namespace: antibiotic_resistance def: "MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs." [PMID:12654672, PMID:9925549] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam synonym: "MexXY-OprM" EXACT CARD_Short_Name [] [Term] id: ARO:3003033 name: mexY namespace: antibiotic_resistance def: "MexY is the RND-type membrane protein of the efflux complex MexXY-OprM." [PMID:9925549] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003032 ! MexXY-OprM relationship: part_of ARO:3003038 ! MexXY-OprA synonym: "mexY" EXACT CARD_Short_Name [] [Term] id: ARO:3003034 name: mexX namespace: antibiotic_resistance def: "MexX is the membrane fusion protein of the MexXY-OprM multidrug efflux complex." [PMID:9925549] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003032 ! MexXY-OprM relationship: part_of ARO:3003038 ! MexXY-OprA synonym: "mexX" EXACT CARD_Short_Name [] [Term] id: ARO:3003035 name: mfpA namespace: antibiotic_resistance def: "mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis." [PMID:15933203] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin synonym: "mfpA" EXACT CARD_Short_Name [] xref: PDB:2BM7 [Term] id: ARO:3003036 name: oleB namespace: antibiotic_resistance def: "oleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion." [PMID:9003412] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "oleB" EXACT CARD_Short_Name [] [Term] id: ARO:3003037 name: opcM namespace: antibiotic_resistance def: "OpcM is an outer membrane factor protein found in Burkholderia cepacia. It is part of the CeoAB-OpcM complex." [PMID:8834871] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003008 ! CeoAB-OpcM synonym: "opcM" EXACT CARD_Short_Name [] [Term] id: ARO:3003038 name: MexXY-OprA namespace: antibiotic_resistance def: "MexXY-OprA is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprA is the outer membrane channel. MexXY-OprA is associated with resistance to aminoglycosides." [PMID:22282519] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic synonym: "MexXY-OprA" EXACT CARD_Short_Name [] [Term] id: ARO:3003039 name: OprA namespace: antibiotic_resistance def: "OprA is an outer membrane factor protein found in Pseudomonas aeruginosa. It is part of the MexXY-OprA complex." [PMID:22282519] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003038 ! MexXY-OprA synonym: "OprA" EXACT CARD_Short_Name [] [Term] id: ARO:3003040 name: beta-lactam resistant penicillin-binding proteins namespace: antibiotic_resistance def: "Pencillin-binding proteins are transpeptidase proteins essential for cell wall synthesis. PBPs bind to penicillin antibiotics, which inactivates the enzyme and therefore disrupts cell wall synthesis. Multiple mechanisms and determinants are implicated in antibiotic resistant PBP." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: derives_from ARO:3000749 ! beta-lactam sensitive penicillin-binding protein [Term] id: ARO:3003041 name: Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin namespace: antibiotic_resistance def: "PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae." [PMID:18394970] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin synonym: "Spne_PBP1a_AMX" EXACT CARD_Short_Name [] [Term] id: ARO:3003042 name: Streptococcus pneumoniae PBP2b conferring resistance to amoxicillin namespace: antibiotic_resistance def: "PBP2b is a penicillin-binding protein found in Streptococcus pneumoniae." [PMID:18394970] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin synonym: "Spne_PBP2b_AMX" EXACT CARD_Short_Name [] [Term] id: ARO:3003043 name: Streptococcus pneumoniae PBP2x conferring resistance to amoxicillin namespace: antibiotic_resistance def: "PBP2x is a penicillin-binding protein found in Streptococcus pneumoniae." [PMID:18394970] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin synonym: "Spne_PBP2x_AMX" EXACT CARD_Short_Name [] [Term] id: ARO:3003046 name: qacA namespace: antibiotic_resistance def: "qacA is a subunit of the qac multidrug efflux pump." [PMID:12820795] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "qacA" EXACT CARD_Short_Name [] [Term] id: ARO:3003047 name: qacB namespace: antibiotic_resistance def: "qacB is a subunit of the qac multidrug efflux pump." [PMID:12820795] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "qacB" EXACT CARD_Short_Name [] [Term] id: ARO:3003048 name: rosA namespace: antibiotic_resistance def: "rosA is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B." [PMID:10931306] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004030 ! RosAB synonym: "rosA" EXACT CARD_Short_Name [] [Term] id: ARO:3003049 name: rosB namespace: antibiotic_resistance def: "rosB is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B." [PMID:10931306] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004030 ! RosAB synonym: "rosB" EXACT CARD_Short_Name [] [Term] id: ARO:3003050 name: SmeABC namespace: antibiotic_resistance def: "SmeABC is a multidrug resistance efflux pump that confers resistance to aminoglycosides, beta-lactams, and fluoroquinolones in Stenotrophomonas maltophilia." [PMID:11796339] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3003051 name: smeA namespace: antibiotic_resistance def: "smeA is the membrane fusion protein of the smeABC multidrug efflux complex in Stenotrophomonas maltophilia." [PMID:11796339] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003050 ! SmeABC synonym: "smeA" EXACT CARD_Short_Name [] [Term] id: ARO:3003052 name: smeB namespace: antibiotic_resistance def: "smeB is the inner membrane multidrug exporter of the efflux complex smeABC in Stenotrophomonas maltophilia." [PMID:11796339] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003050 ! SmeABC synonym: "smeB" EXACT CARD_Short_Name [] [Term] id: ARO:3003053 name: smeC namespace: antibiotic_resistance def: "smeC is an outer membrane multidrug efflux protein of the smeABC complex in Stenotrophomonas maltophilia." [PMID:11796339] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003050 ! SmeABC synonym: "smeC" EXACT CARD_Short_Name [] [Term] id: ARO:3003054 name: SmeDEF namespace: antibiotic_resistance def: "SmeDEF is a multidrug resistance efflux pump that confers resistance to quinolones, tetracyclines, macrolides, chloramphenicol, and novobiocin in Stenotrophomonas maltophilia." [PMID:11709330] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic [Term] id: ARO:3003055 name: smeD namespace: antibiotic_resistance def: "smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia." [PMID:11709330] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003054 ! SmeDEF synonym: "smeD" EXACT CARD_Short_Name [] [Term] id: ARO:3003056 name: smeE namespace: antibiotic_resistance def: "smeE is the RND protein of the efflux complex smeDEF in Stenotrophomonas maltophilia." [PMID:11709330] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003054 ! SmeDEF synonym: "smeE" EXACT CARD_Short_Name [] [Term] id: ARO:3003057 name: smeF namespace: antibiotic_resistance def: "smeF is an outer membrane multidrug efflux protein of the smeDEF complex in Stenotrophomonas maltophilia." [PMID:11709330] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003054 ! SmeDEF synonym: "smeF" EXACT CARD_Short_Name [] [Term] id: ARO:3003059 name: tmrB namespace: antibiotic_resistance def: "tmrB is an ATP-binding tunicamycin resistance protein found in Bacillus subtilis." [PMID:7766032] is_a: ARO:3004285 ! tunicamycin resistance protein relationship: confers_resistance_to_antibiotic ARO:0000009 ! tunicamycin synonym: "tmrB" EXACT CARD_Short_Name [] [Term] id: ARO:3003060 name: tsnR namespace: antibiotic_resistance def: "tsnR is a 23S ribosomal RNA methyltransferase that methylates adenosine-1067 to confer resistance to thiostrepton." [PMID:7590303] is_a: ARO:3003065 ! non-erm 23S ribosomal RNA methyltransferase (A1067) relationship: confers_resistance_to_antibiotic ARO:3000686 ! thiostrepton synonym: "tsnR" EXACT CARD_Short_Name [] [Term] id: ARO:3003061 name: vph namespace: antibiotic_resistance def: "vph is a phosphotransferase that confers resistance to viomycin in Streptomyces vinaceus." [PMID:2987648] is_a: ARO:3004261 ! viomycin phosphotransferase relationship: confers_resistance_to_antibiotic ARO:0000018 ! viomycin synonym: "vph" EXACT CARD_Short_Name [] [Term] id: ARO:3003062 name: ykkCD namespace: antibiotic_resistance def: "ykkCD is a multidrug efflux pump with two SMR-type protein subunits that confers resistance to cationic drugs, chloramphenicol, streptomycin and tetracycline." [PMID:10735877] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol [Term] id: ARO:3003063 name: ykkC namespace: antibiotic_resistance def: "ykkC is an SMR-type protein that is a subunit of the ykkCD efflux pump." [PMID:10735877] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003062 ! ykkCD synonym: "ykkC" EXACT CARD_Short_Name [] [Term] id: ARO:3003064 name: ykkD namespace: antibiotic_resistance def: "ykkD is an SMR-type protein that is a subunit of the ykkCD efflux pump." [PMID:10735877] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003062 ! ykkCD synonym: "ykkD" EXACT CARD_Short_Name [] [Term] id: ARO:3003065 name: non-erm 23S ribosomal RNA methyltransferase (A1067) namespace: antibiotic_resistance def: "Non-erm 23S ribosomal RNA methyltransferases modify adenosine 1067 to confer resistance to peptide antibiotics." [] is_a: ARO:3004274 ! 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003066 name: smeR namespace: antibiotic_resistance def: "smeR is the responder component of a two component signal transduction system that includes smeS." [PMID:11796339] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3003068 ! smeRS synonym: "smeR" EXACT CARD_Short_Name [] [Term] id: ARO:3003067 name: smeS namespace: antibiotic_resistance def: "smeS is the protein kinase sensor component of a two component signal transduction system that includes smeR." [PMID:11796339] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3003068 ! smeRS synonym: "smeS" EXACT CARD_Short_Name [] [Term] id: ARO:3003068 name: smeRS namespace: antibiotic_resistance def: "smeRS is a two component regulatory system for smeABC where smeR is a response regulator, while smeS is a sensor kinase." [] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3003050 ! SmeABC [Term] id: ARO:3003069 name: vanXY gene in vanG cluster namespace: antibiotic_resistance def: "Also known as vanXYG, is a vanXY variant found in the vanG gene cluster." [PMID:16723588] is_a: ARO:3000496 ! vanXY relationship: part_of ARO:3000257 ! glycopeptide resistance gene cluster VanG synonym: "vanXY-G" EXACT [] synonym: "vanXYG" EXACT [] synonym: "vanXY_in_vanG" EXACT CARD_Short_Name [] synonym: "vanYG2" EXACT [] [Term] id: ARO:3003070 name: vanX gene in vanD cluster namespace: antibiotic_resistance def: "Also known as vanXD, is a vanX variant found in the vanD gene cluster." [PMID:12499162] is_a: ARO:3000011 ! vanX relationship: part_of ARO:3000253 ! glycopeptide resistance gene cluster VanD synonym: "vanX-D" EXACT [] synonym: "vanXD" EXACT [] synonym: "vanX_in_vanD_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3003071 name: mphF namespace: antibiotic_resistance def: "mphF is a macrolide phosphotransferase and resistance gene identified on the IncP plasmid pRSB111." [PMID:17101677, PMID:29317655] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "mphF" EXACT CARD_Short_Name [] [Term] id: ARO:3003072 name: mphL namespace: antibiotic_resistance def: "mphL is a chromosomally-encoded macrolide phosphotransferases that inactivate 14- and 15-membered macrolides such as erythromycin, clarithromycin, azithromycin." [PMID:25059531, PMID:29317655] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "mphL" EXACT CARD_Short_Name [] [Term] id: ARO:3003074 name: Staphylococcus aureus cls conferring resistance to daptomycin namespace: antibiotic_resistance def: "Cardiolipin synthetase (cls) is an inner membrane protein that is involved in membrane synthesis. Specific mutations in S. aureus can confer resistance to daptomycin." [PMID:22238576] is_a: ARO:3003272 ! daptomycin resistant cls relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Saur_cls_DAP" EXACT CARD_Short_Name [] synonym: "cls1" EXACT [] synonym: "cls2" EXACT [] [Term] id: ARO:3003076 name: daptomycin resistant liaFSR namespace: antibiotic_resistance def: "liaFSR is a two-component signal transduction pathway in B. subtilis that responds to peptide and lipopeptide antibiotics. The liaFSR two-component system consists of a histidine kinase liaS and the response regulator liaR as well as the accessory protein liaF, which acts as a negative regulator of liaRS-dependent signal transduction. Mutations confer resistance to daptomycin." [PMID:21899450] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux [Term] id: ARO:3003077 name: Enterococcus faecalis liaF mutant conferring daptomycin resistance namespace: antibiotic_resistance def: "liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance." [PMID:23959318, PMID:21899450] is_a: ARO:3003279 ! antibiotic resistant liaFSR system is_a: ARO:3004262 ! daptomycin resistant liaF relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efae_liaF_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003078 name: Enterococcus faecium liaR mutant conferring daptomycin resistance namespace: antibiotic_resistance def: "liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance." [PMID:21899450] is_a: ARO:3003279 ! antibiotic resistant liaFSR system is_a: ARO:3004263 ! daptomycin resistant liaR relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efac_liaR_DAP" EXACT CARD_Short_Name [] synonym: "yvqE" EXACT [] [Term] id: ARO:3003079 name: Enterococcus faecium liaS mutant conferring daptomycin resistance namespace: antibiotic_resistance def: "liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance." [PMID:21899450, PMID:22664970] is_a: ARO:3003279 ! antibiotic resistant liaFSR system is_a: ARO:3004264 ! daptomycin resistant liaS relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efac_liaS_DAP" EXACT CARD_Short_Name [] synonym: "yvqC" EXACT [] [Term] id: ARO:3003080 name: daptomycin resistant pgsA namespace: antibiotic_resistance def: "pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. Laboratory experiments have detected mutations conferring daptomycin resistance in Entercoccus." [PMID:22238576, PMID:21709092] is_a: ARO:3003420 ! antibiotic resistant pgsA relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic synonym: "phosphatidylglycerophosphate synthetase" EXACT [] [Term] id: ARO:3003090 name: daptomycin resistant beta-subunit of RNA polymerase (rpoB) namespace: antibiotic_resistance def: "Daptomycin resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus." [PMID:20837752] is_a: ARO:3003276 ! antibiotic resistant rpoB relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic relationship: derives_from ARO:3003278 ! daptomycin sensitive beta-subunit of RNA polymerase (rpoB) [Term] id: ARO:3003091 name: daptomycin resistant mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in mprF can additionally confer resistance to daptomycin in S. aureus." [PMID:20498310, PMID:16723576, PMID:22238576] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3003421 ! antibiotic resistant mprF relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: derives_from ARO:3003280 ! antibiotic sensitive mprF [Term] id: ARO:3003092 name: Enterococcus faecium cls conferring resistance to daptomycin namespace: antibiotic_resistance def: "cls or cardiolipin synthetase is an inner membrane protein that is involved in membrane synthesis. Specific mutations in Enterococcus can confer resistance to daptomycin." [PMID:23114777, PMID:26454536, PMID:23580562, PMID:22948885, PMID:21899450] is_a: ARO:3003272 ! daptomycin resistant cls relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: derives_from ARO:3003275 ! Daptomycin sensitive cardiolipin synthetase synonym: "Efac_cls_DAP" EXACT CARD_Short_Name [] synonym: "cls1" EXACT [] synonym: "cls2" EXACT [] [Term] id: ARO:3003093 name: cphA3 namespace: antibiotic_resistance def: "CEPH-A3 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein." [] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "cphA3" EXACT CARD_Short_Name [] [Term] id: ARO:3003094 name: imiH namespace: antibiotic_resistance def: "imiH is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems." [PMID:12746371] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "imiH" EXACT CARD_Short_Name [] [Term] id: ARO:3003095 name: imiS namespace: antibiotic_resistance def: "imiS is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems." [PMID:9527802] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "imiS" EXACT CARD_Short_Name [] [Term] id: ARO:3003096 name: CfxA5 namespace: antibiotic_resistance def: "CfxA5 beta-lactamase is a class A beta-lactamase found in Bacteroides distasonis." [PMID:24606061] is_a: ARO:3003000 ! CfxA beta-lactamase synonym: "CfxA5" EXACT CARD_Short_Name [] [Term] id: ARO:3003097 name: CfxA6 namespace: antibiotic_resistance def: "CfxA6 beta-lactamase is a class A beta-lactamase found in an uncultured bacterium." [PMID:19713526] is_a: ARO:3003000 ! CfxA beta-lactamase synonym: "CfxA6" EXACT CARD_Short_Name [] [Term] id: ARO:3003099 name: cphA2 namespace: antibiotic_resistance def: "CphA2 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein." [PMID:9021171, PMID:22009263] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "cphA2" EXACT CARD_Short_Name [] xref: PDB:2QDS [Term] id: ARO:3003100 name: cphA4 namespace: antibiotic_resistance def: "CphA4 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas allosaccharophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein." [] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "cphA4" EXACT CARD_Short_Name [] [Term] id: ARO:3003101 name: cphA5 namespace: antibiotic_resistance def: "cphA5 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas salmonicida. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein." [] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "cphA5" EXACT CARD_Short_Name [] [Term] id: ARO:3003102 name: cphA6 namespace: antibiotic_resistance def: "cphA6 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein." [] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "cphA6" EXACT CARD_Short_Name [] [Term] id: ARO:3003103 name: cphA7 namespace: antibiotic_resistance def: "cphA7 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas jandaei. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein." [] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "cphA7" EXACT CARD_Short_Name [] [Term] id: ARO:3003104 name: cphA8 namespace: antibiotic_resistance def: "cphA8 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas sobria. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein." [] is_a: ARO:3000581 ! CphA beta-lactamase synonym: "cphA8" EXACT CARD_Short_Name [] [Term] id: ARO:3003105 name: dfrA3 namespace: antibiotic_resistance def: "dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli." [PMID:20169085] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: derives_from ARO:3000745 ! antibiotic sensitive dihydrofolate reductase synonym: "dfrA3" EXACT CARD_Short_Name [] [Term] id: ARO:3003106 name: Erm(42) namespace: antibiotic_resistance def: "Erm42 confers MLSb phenotype in Pasteurella multocida." [PMID:21402855] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "Erm(42)" EXACT CARD_Short_Name [] synonym: "Erm42" EXACT [] [Term] id: ARO:3003107 name: mef(B) namespace: antibiotic_resistance def: "mef(B) is a macrolide efflux gene located in the vicinity of sul3 in Escherichia coli. There is also a mefB found in Streptococcus agalactiae that confers resistance to macrolides." [PMID:19131424, PMID:27052334] is_a: ARO:3000747 ! mef relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "mef(B)" EXACT CARD_Short_Name [] synonym: "mefB" EXACT [] [Term] id: ARO:3003109 name: msrE namespace: antibiotic_resistance def: "MsrE is an ABC-F subfamily protein expressed to Klebsiella pneumoniae that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. It is also 100% identical to ABC-F type ribosomal protection protein Msr(E) which is in multiple species." [PMID:23114767] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "msr(E)" EXACT [] synonym: "msrE" EXACT CARD_Short_Name [] [Term] id: ARO:3003110 name: catB10 namespace: antibiotic_resistance def: "catB10 is an integron-encoded variant of the cat gene found in P. aeruginosa." [PMID:20735174] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "catB10" EXACT CARD_Short_Name [] [Term] id: ARO:3003111 name: lsaB namespace: antibiotic_resistance def: "LsaB is an ABC-F subfamily protein expressed in Mammaliicoccus sciuri. It confers resistance to clindamycin." [PMID:21245447, PMID:15471995] is_a: ARO:3004472 ! lsa-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3001317 ! pleuromutilin synonym: "lsaB" EXACT CARD_Short_Name [] [Term] id: ARO:3003112 name: lsaC namespace: antibiotic_resistance def: "LsaC is an ABC-F subfamily protein expressed in Streptococcus agalactiae. It confers resistance to lincomycin, clindamycin, dalfopristin, and tiamulin." [PMID:21245447] is_a: ARO:3004472 ! lsa-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3001317 ! pleuromutilin synonym: "lsaC" EXACT CARD_Short_Name [] [Term] id: ARO:3003113 name: TEM-221 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3003114 name: TEM-222 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3003115 name: OXA-427 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3007719 ! OXA-427-like beta-lactamase synonym: "OXA-427" EXACT CARD_Short_Name [] [Term] id: ARO:3003116 name: OXA-420 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3007728 ! OXA-58-like beta-lactamase synonym: "OXA-420" EXACT CARD_Short_Name [] [Term] id: ARO:3003117 name: OXA-421 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-421" EXACT CARD_Short_Name [] [Term] id: ARO:3003119 name: OXA-428 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003120 name: OXA-429 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-429" EXACT CARD_Short_Name [] [Term] id: ARO:3003121 name: OXA-430 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-430" EXACT CARD_Short_Name [] [Term] id: ARO:3003124 name: OXA-431 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-431" EXACT CARD_Short_Name [] [Term] id: ARO:3003125 name: OXA-432 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-432" EXACT CARD_Short_Name [] [Term] id: ARO:3003126 name: OXA-433 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-433" EXACT CARD_Short_Name [] [Term] id: ARO:3003127 name: OXA-434 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003128 name: OXA-436 namespace: antibiotic_resistance def: "An OXA-48-like plasmid-encoded beta-lactamase shown to confer resistance to carbapenems through hydrolysis. Identified in multiple Enterobacteriaceae isolates from several patients in Denmark. Beta-lactamase activity against carbapenems and penicillins but little to no activity against cephalosporin antibiotics. Described by Samuelsen et al. 2017." [PMID:29061750] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-436" EXACT CARD_Short_Name [] [Term] id: ARO:3003129 name: CMY-121 namespace: antibiotic_resistance def: "CMY-121 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-SEP-2014." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-121" EXACT CARD_Short_Name [] [Term] id: ARO:3003130 name: CMY-122 namespace: antibiotic_resistance def: "CMY-122 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-MAY-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-122" EXACT CARD_Short_Name [] [Term] id: ARO:3003131 name: CMY-123 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000069 ! CMY beta-lactamase [Term] id: ARO:3003132 name: CMY-124 namespace: antibiotic_resistance def: "CMY-124 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-124" EXACT CARD_Short_Name [] [Term] id: ARO:3003133 name: CMY-125 namespace: antibiotic_resistance def: "CMY-125 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-MAY-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-125" EXACT CARD_Short_Name [] [Term] id: ARO:3003134 name: CMY-126 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000069 ! CMY beta-lactamase [Term] id: ARO:3003135 name: CMY-127 namespace: antibiotic_resistance def: "CMY-127 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-OCT-2014." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-127" EXACT CARD_Short_Name [] [Term] id: ARO:3003136 name: CMY-128 namespace: antibiotic_resistance def: "CMY-128 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-OCT-2014." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-128" EXACT CARD_Short_Name [] [Term] id: ARO:3003137 name: CMY-129 namespace: antibiotic_resistance def: "CMY-129 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-OCT-2014." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-129" EXACT CARD_Short_Name [] [Term] id: ARO:3003138 name: CMY-130 namespace: antibiotic_resistance def: "CMY-130 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin." [PMID:26048440] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-130" EXACT CARD_Short_Name [] [Term] id: ARO:3003139 name: MIR-18 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-18" EXACT CARD_Short_Name [] [Term] id: ARO:3003140 name: MOX-10 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-10" EXACT CARD_Short_Name [] [Term] id: ARO:3003141 name: MOX-11 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-11" EXACT CARD_Short_Name [] [Term] id: ARO:3003142 name: IMI-8 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-8" EXACT CARD_Short_Name [] [Term] id: ARO:3003143 name: IMI-9 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-9" EXACT CARD_Short_Name [] [Term] id: ARO:3003144 name: KPC-20 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000059 ! KPC beta-lactamase [Term] id: ARO:3003145 name: KPC-21 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-21" EXACT CARD_Short_Name [] [Term] id: ARO:3003146 name: VEB-10 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-10" EXACT CARD_Short_Name [] [Term] id: ARO:3003147 name: OXA-424 namespace: antibiotic_resistance def: "OXA-424 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii found in China. It is carbapenem resistant." [PMID:25487793] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-424" EXACT CARD_Short_Name [] [Term] id: ARO:3003148 name: OXA-425 namespace: antibiotic_resistance def: "OXA-425 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem-resistant." [PMID:25487793] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-425" EXACT CARD_Short_Name [] [Term] id: ARO:3003149 name: OXA-426 namespace: antibiotic_resistance def: "OXA-426 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem resistant." [PMID:25487793] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-426" EXACT CARD_Short_Name [] [Term] id: ARO:3003150 name: CARB-20 namespace: antibiotic_resistance def: "CARB-20 is a beta-lactamase found worldwide in Vibrio parahaemolyticus." [PMID:23469330] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-20" EXACT CARD_Short_Name [] [Term] id: ARO:3003151 name: CARB-22 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-22" EXACT CARD_Short_Name [] [Term] id: ARO:3003152 name: SHV-185 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-185" EXACT CARD_Short_Name [] [Term] id: ARO:3003153 name: SHV-186 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-186" EXACT CARD_Short_Name [] [Term] id: ARO:3003154 name: SHV-187 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-187" EXACT CARD_Short_Name [] [Term] id: ARO:3003155 name: SHV-188 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-188" EXACT CARD_Short_Name [] [Term] id: ARO:3003156 name: SHV-189 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-189" EXACT CARD_Short_Name [] [Term] id: ARO:3003157 name: TEM-219 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-219" EXACT CARD_Short_Name [] [Term] id: ARO:3003158 name: TEM-220 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-220" EXACT CARD_Short_Name [] [Term] id: ARO:3003159 name: OXA-419 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases. Not yet released." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003160 name: OXA-422 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-422" EXACT CARD_Short_Name [] [Term] id: ARO:3003161 name: OXA-423 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-423" EXACT CARD_Short_Name [] [Term] id: ARO:3003162 name: OXA-435 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-435" EXACT CARD_Short_Name [] [Term] id: ARO:3003163 name: CTX-M-155 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-155" EXACT CARD_Short_Name [] [Term] id: ARO:3003164 name: CTX-M-156 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-156" EXACT CARD_Short_Name [] [Term] id: ARO:3003165 name: CTX-M-157 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-157" EXACT CARD_Short_Name [] [Term] id: ARO:3003166 name: CTX-M-158 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-158" EXACT CARD_Short_Name [] [Term] id: ARO:3003167 name: CTX-M-159 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-159" EXACT CARD_Short_Name [] [Term] id: ARO:3003168 name: CTX-M-160 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-160" EXACT CARD_Short_Name [] [Term] id: ARO:3003169 name: CTX-M-161 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-161" EXACT CARD_Short_Name [] [Term] id: ARO:3003170 name: CMY-131 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-131" EXACT CARD_Short_Name [] [Term] id: ARO:3003171 name: ACT-36 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-36" EXACT CARD_Short_Name [] [Term] id: ARO:3003172 name: ACT-37 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-37" EXACT CARD_Short_Name [] [Term] id: ARO:3003173 name: MIR-17 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-17" EXACT CARD_Short_Name [] [Term] id: ARO:3003174 name: CARB-18 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-18" EXACT CARD_Short_Name [] [Term] id: ARO:3003175 name: CARB-19 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-19" EXACT CARD_Short_Name [] [Term] id: ARO:3003176 name: CARB-21 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-21" EXACT CARD_Short_Name [] [Term] id: ARO:3003177 name: IMI-7 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-7" EXACT CARD_Short_Name [] [Term] id: ARO:3003178 name: VIM-42 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-42" EXACT CARD_Short_Name [] [Term] id: ARO:3003179 name: VIM-43 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-43" EXACT CARD_Short_Name [] [Term] id: ARO:3003180 name: KPC-22 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-22" EXACT CARD_Short_Name [] [Term] id: ARO:3003181 name: GES-26 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-26" EXACT CARD_Short_Name [] [Term] id: ARO:3003182 name: NDM-13 namespace: antibiotic_resistance def: "Beta-lactamase found in Escherichia coli clinical isolates in Nepal." [PMID:26169399] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-13" EXACT CARD_Short_Name [] [Term] id: ARO:3003183 name: NDM-14 namespace: antibiotic_resistance def: "NDM-14 is a beta-lactamase found in Acinetobacter lwoffii." [PMID:25645836] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-14" EXACT CARD_Short_Name [] [Term] id: ARO:3003184 name: PER-8 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-8" EXACT CARD_Short_Name [] [Term] id: ARO:3003185 name: GES-25 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, not yet released." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-25" EXACT CARD_Short_Name [] [Term] id: ARO:3003186 name: CARB-23 namespace: antibiotic_resistance def: "Present in Lahey's list of beta-lactamases, not yet released." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-23" EXACT CARD_Short_Name [] [Term] id: ARO:3003187 name: QnrB75 namespace: antibiotic_resistance def: "QnrB75 is a fluoroquinolone resistance gene in Lahey's list of qnr genes." [] is_a: ARO:3000419 ! quinolone resistance protein (qnr) synonym: "QnrB75" EXACT CARD_Short_Name [] [Term] id: ARO:3003188 name: QnrB76 namespace: antibiotic_resistance def: "QnrB76 is a fluoroquinolone resistance gene in Lahey's list of qnr genes." [] is_a: ARO:3000419 ! quinolone resistance protein (qnr) synonym: "QnrB76" EXACT CARD_Short_Name [] [Term] id: ARO:3003189 name: QnrB77 namespace: antibiotic_resistance def: "QnrB77 is a fluoroquinolone resistance gene in Lahey's list of qnr genes." [] is_a: ARO:3000419 ! quinolone resistance protein (qnr) synonym: "QnrB77" EXACT CARD_Short_Name [] [Term] id: ARO:3003190 name: QnrB78 namespace: antibiotic_resistance def: "QnrB78 is a fluoroquinolone resistance gene in Lahey's list of qnr genes." [] is_a: ARO:3000419 ! quinolone resistance protein (qnr) synonym: "QnrB78" EXACT CARD_Short_Name [] [Term] id: ARO:3003192 name: QnrB80 namespace: antibiotic_resistance def: "QnrB80 is a fluoroquinolone resistance gene in Lahey's list of qnr genes." [] is_a: ARO:3000419 ! quinolone resistance protein (qnr) synonym: "QnrB80" EXACT CARD_Short_Name [] [Term] id: ARO:3003193 name: QnrVC7 namespace: antibiotic_resistance def: "QnrVC7 is a fluoroquinolone resistance gene in Lahey's list of qnr genes." [PMID:23595824] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrVC7" EXACT CARD_Short_Name [] [Term] id: ARO:3003194 name: GIM-2 namespace: antibiotic_resistance def: "GIM-2 is a metallo-beta-lactamase present on an integron found in clinical isolates of Enterobacter cloacae in Germany." [] is_a: ARO:3003195 ! GIM beta-lactamase synonym: "GIM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3003195 name: GIM beta-lactamase namespace: antibiotic_resistance def: "GIM beta-lactamase enzymes isolated from Pseudomonas aeruginosa, and found to confer broad-spectrum resistance to beta-lactam antibiotics." [PMID:15561840] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem synonym: "blaGIM-1" EXACT [] [Term] id: ARO:3003196 name: tet(45) namespace: antibiotic_resistance def: "Tet45 is a tetracycline efflux pump found in Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil." [PMID:23595824, PMID:22001175] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(45)" EXACT CARD_Short_Name [] synonym: "tet45" EXACT [] [Term] id: ARO:3003197 name: aadA25 namespace: antibiotic_resistance def: "Streptomycin/spectinomycin resistance gene found in Pasteurella multocida isolated from bovine respiratory tract." [PMID:22001175] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA25" EXACT CARD_Short_Name [] [Term] id: ARO:3003198 name: rmtH namespace: antibiotic_resistance def: "rmtH is a 16s ribosomal RNA methyltransferase found in Klebsiella pneumoniae strain MRSN2404 that was isolated from the chronic wound of a soldier wounded in Iraq in 2006. It confers high resistance to aminoglycosides." [PMID:23478957] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000654 ! arbekacin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "rmtH" EXACT CARD_Short_Name [] [Term] id: ARO:3003199 name: AAC(6')-Iak namespace: antibiotic_resistance def: "AAC(6')-Iak is a 6'-N-aminoglycoside acetyltransferase-encoding gene isolated from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia." [PMID:25092711] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iak" EXACT CARD_Short_Name [] [Term] id: ARO:3003200 name: AAC(6')-Ian namespace: antibiotic_resistance def: "AAC(6')-Ian is an amikacin acetyltransferase gene found on a transferable plasmid of the Serratia marcescens strain NUBL-11663. It catalyzes the transfer of an acetyl group from acetyl coenzyme A onto an amine at the 6'-position of various aminoglycosides." [PMID:25576529] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Ian" EXACT CARD_Short_Name [] [Term] id: ARO:3003201 name: TLA beta-lactamase namespace: antibiotic_resistance def: "The TLA beta-lactamases are resistant to expanded-spectrum cephalosporins, and aztreonam but was susceptible to amikacin, cefotetan, and imipenem." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3003202 name: TLA-1 namespace: antibiotic_resistance def: "TLA-1 is a beta-lactamase found in plasmids of clinical isolates of Escherichia coli strain R170 in Latin America. It preferentially hydrolyzed cephaloridine, cefotaxime, cephalothin, benzylpenicillin, and ceftazidime. The enzyme was markedly inhibited by sulbactam, tazobactam, and clavulanic acid." [PMID:15095209] is_a: ARO:3003201 ! TLA beta-lactamase synonym: "TLA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003203 name: TLA-2 namespace: antibiotic_resistance def: "TLA-2 is a beta-lactamase is present on a plasmid isolated from an unidentified bacterial strain from a waste water treatment plant. The enzyme mostly hydrolyzes cephalosporins." [PMID:16251326] is_a: ARO:3003201 ! TLA beta-lactamase synonym: "TLA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3003204 name: TLA-3 namespace: antibiotic_resistance def: "TLA-3 is a beta-lactamase found in a transferable plasmid of Serratia marcescens clinical isolate. It confers resistance to ceftazidime, cefotaxime and cefepime, but not to cefmetazole and meropenem." [PMID:25576529] is_a: ARO:3003201 ! TLA beta-lactamase synonym: "TLA-3" EXACT CARD_Short_Name [] [Term] id: ARO:3003205 name: Erm(43) namespace: antibiotic_resistance def: "Erm(43) is a macrolide, lincosamide, and streptogramin B resistance gene found in Mammaliicoccus lentus chromosome isolated from human, dog and chicken." [PMID:22733067] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA synonym: "Erm(43)" EXACT CARD_Short_Name [] [Term] id: ARO:3003206 name: lsaE namespace: antibiotic_resistance def: "lsaE is an ABC-F subfamily protein found in porcine MRSA isolates. It confers resistance to pleuromutilin, lincosamide, and streptogramin A." [PMID:23386262, PMID:21245447] is_a: ARO:3004472 ! lsa-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3001317 ! pleuromutilin synonym: "lsaE" EXACT CARD_Short_Name [] [Term] id: ARO:3003207 name: FosK namespace: antibiotic_resistance def: "FosK is a fosfomycin thiol transferase isolated from Acinetobacter soli. It is integrin-mediated. It confers a high level of resistance to fosfomycin." [PMID:24841262] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosK" EXACT CARD_Short_Name [] [Term] id: ARO:3003208 name: FosXCC namespace: antibiotic_resistance def: "fosXCC is a fosfomycin resistance gene that modifies MurA isolated from Campylobacter species. It is highly resistant to fosfomycin." [PMID:25433007] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosXCC" EXACT CARD_Short_Name [] [Term] id: ARO:3003209 name: fosA5 namespace: antibiotic_resistance def: "fosA5 is a fosfomycin resistance gene isolated from clinical strain of Escherichia coli E265. It is susceptible to amikacin, tetracycline and imipenem, and resistant to sulphonamide, cephalosporins, gentamicin, ciprofloxacin, chloramphenicol and streptomycin." [PMID:25441705] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "fosA5" EXACT CARD_Short_Name [] [Term] id: ARO:3003210 name: FosA4 namespace: antibiotic_resistance def: "FosA4 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule." [PMID:24951800] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosA4" EXACT CARD_Short_Name [] [Term] id: ARO:3003211 name: 16S rRNA with mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "Many antibiotics inhibit the growth of bacteria by blocking protein synthesis on the ribosome. The antibiotic-binding sites are located within functionally important structures in the ribosomal RNA. Antibiotic resistance is often conferred by base substitutions or methylations at these sites in the rRNA. Point mutations in the bacterial 16S ribosomal RNA in the small 30S subunit can confer resistance to antibiotics." [PMID:8065453, PMID:16261170, PMID:16269538] is_a: ARO:3000328 ! rRNA with mutation conferring antibiotic resistance relationship: derives_from ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003223 name: Escherichia coli 16S rRNA mutation conferring resistance to edeine namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of the 16S rRNA in Escherichia coli can confer resistance to edeine." [PMID:16269538] is_a: ARO:3003667 ! 16s rRNA with mutation conferring resistance to peptide antibiotics relationship: confers_resistance_to_antibiotic ARO:3000130 ! edeine A relationship: confers_resistance_to_antibiotic ARO:3000134 ! edeine B relationship: confers_resistance_to_antibiotic ARO:3000135 ! edeine D relationship: confers_resistance_to_antibiotic ARO:3000136 ! edeine F synonym: "Ecol_16S_EDN" EXACT CARD_Short_Name [] [Term] id: ARO:3003231 name: Lipid II namespace: antibiotic_resistance def: "Precursor molecule during the synthesis of bacterial cell wall. Lipid II anchors itself onto the cell and it's disaccharide-peptide subunit is used in PG polymer assembly by peptidoglycan glycosyltransferases. Due to it's importance in cell wall synthesis, it is the target of antibiotics." [PMID:25291014] is_a: ARO:3000721 ! cell wall component targeted by antibiotic relationship: targeted_by_antibiotic ARO:3003241 ! teixobactin [Term] id: ARO:3003232 name: Lipid III namespace: antibiotic_resistance def: "Lipid III is the precursor to the wall teichoic acid. It's inhibition leads to bacterial death as teichoic acid is required to anchor autolysins which control the hydrolysis of peptidoglycan cell wall." [PMID:25561178] is_a: ARO:3000721 ! cell wall component targeted by antibiotic relationship: targeted_by_antibiotic ARO:3003241 ! teixobactin synonym: "Undecaprenyl Pyrophosphate N-Acetylglucosamine" EXACT [] synonym: "Undecaprenyl-PP-GlcNAc" EXACT [] [Term] id: ARO:3003236 name: Mycobacteroides abscessus 16S rRNA mutation conferring resistance to kanamycin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to kanamycin." [PMID:21652621, PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Mabs_16S_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3003237 name: Mycobacteroides abscessus 16S rRNA mutation conferring resistance to tobramycin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to tobramycin." [PMID:9607835, PMID:21652621] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "Mabs_16S_TOB" EXACT CARD_Short_Name [] [Term] id: ARO:3003238 name: Mycobacteroides abscessus 16S rRNA mutation conferring resistance to neomycin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to neomycin." [PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin synonym: "Mabs_16S_NEO" EXACT CARD_Short_Name [] [Term] id: ARO:3003239 name: Mycobacteroides abscessus 16S rRNA mutation conferring resistance to amikacin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to amikacin." [PMID:21652621, PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin synonym: "Mabs_16S_AMK" EXACT CARD_Short_Name [] [Term] id: ARO:3003240 name: Mycobacteroides abscessus 16S rRNA mutation conferring resistance to gentamicin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to gentamicin." [PMID:21652621, PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C synonym: "Mabs_16S_GEN" EXACT CARD_Short_Name [] [Term] id: ARO:3003241 name: teixobactin namespace: antibiotic_resistance def: "Teixobactin is a peptide antibiotic isolated from the Gram-negative bacteria, Eleftheria terrae. It inhibits the synthesis of peptidoglycan by interacting with peptidoglycan precursor, Lipid II and Lipid III." [PMID:25561178] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:86341926 [Term] id: ARO:3003250 name: bcrC namespace: antibiotic_resistance def: "The bcrC gene product (BcrC) is an undecaprenyl pyrophosphate phosphatase originally isolated from Bacillus subtilis. When overexpressed it can confer resistance to bacitracin." [PMID:15946938] is_a: ARO:3003398 ! undecaprenyl pyrophosphate related proteins relationship: confers_resistance_to_antibiotic ARO:3000629 ! bacitracin A relationship: confers_resistance_to_antibiotic ARO:3000630 ! bacitracin B relationship: confers_resistance_to_antibiotic ARO:3000631 ! bacitracin F synonym: "bcrC" EXACT CARD_Short_Name [] [Term] id: ARO:3003251 name: undecaprenyl pyrophosphate namespace: antibiotic_resistance def: "Undecaprenyl pyrophosphate is a precursor to a cell wall polymer carrier. It's activation requires a phosphatase." [] is_a: ARO:3000721 ! cell wall component targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000041 ! bacitracin relationship: targeted_by_antibiotic ARO:3000629 ! bacitracin A relationship: targeted_by_antibiotic ARO:3000630 ! bacitracin B relationship: targeted_by_antibiotic ARO:3000631 ! bacitracin F [Term] id: ARO:3003253 name: aminocoumarin sensitive parY namespace: antibiotic_resistance def: "Subunit of topoisomerase IV sensitive to aminocourmarins." [PMID:1260451] is_a: ARO:3003258 ! Antibiotic sensitive DNA topoisomerase subunit parY relationship: targeted_by ARO:3000103 ! aminocoumarin antibiotic relationship: targeted_by_antibiotic ARO:3000111 ! novobiocin relationship: targeted_by_antibiotic ARO:3000132 ! clorobiocin relationship: targeted_by_antibiotic ARO:3000150 ! coumermycin A1 [Term] id: ARO:3003254 name: antibiotic sensitive DNA topoisomerase subunit gyrA namespace: antibiotic_resistance def: "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling." [PMID:1657531] is_a: ARO:3000766 ! antibiotic sensitive topoisomerase subunit [Term] id: ARO:3003256 name: antibiotic sensitive DNA topoisomerase subunit parC namespace: antibiotic_resistance def: "ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks." [PMID:1657531] is_a: ARO:3000766 ! antibiotic sensitive topoisomerase subunit [Term] id: ARO:3003258 name: Antibiotic sensitive DNA topoisomerase subunit parY namespace: antibiotic_resistance def: "parY is a subunit of the topoisomerase IV. It decatenates and relaxes DNA to allow for transcription or translation." [] is_a: ARO:3000766 ! antibiotic sensitive topoisomerase subunit [Term] id: ARO:3003259 name: antibiotic sensitive DNA topoisomerase subunit parE namespace: antibiotic_resistance def: "ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks." [PMID:12604514] is_a: ARO:3000766 ! antibiotic sensitive topoisomerase subunit [Term] id: ARO:3003260 name: aminocoumarin sensitive gyrB namespace: antibiotic_resistance def: "Beta-subunit of DNA gyrase sensitive to inhibition by aminocoumarins." [] is_a: ARO:3000734 ! antibiotic sensitive DNA topoisomerase subunit gyrB relationship: targeted_by ARO:3000103 ! aminocoumarin antibiotic relationship: targeted_by_antibiotic ARO:3000111 ! novobiocin relationship: targeted_by_antibiotic ARO:3000132 ! clorobiocin relationship: targeted_by_antibiotic ARO:3000150 ! coumermycin A1 [Term] id: ARO:3003261 name: fluoroquinolone sensitive gyrB namespace: antibiotic_resistance def: "Beta-subunit of DNA gyrase sensitive to inhibition by fluoroquinolones." [] is_a: ARO:3000734 ! antibiotic sensitive DNA topoisomerase subunit gyrB relationship: targeted_by ARO:0000001 ! fluoroquinolone antibiotic relationship: targeted_by_antibiotic ARO:0000036 ! ciprofloxacin relationship: targeted_by_antibiotic ARO:3004010 ! cinoxacin relationship: targeted_by_antibiotic ARO:3004011 ! clinafloxacin relationship: targeted_by_antibiotic ARO:3004012 ! clofazimine relationship: targeted_by_antibiotic ARO:3004013 ! fleroxacin [Term] id: ARO:3003262 name: Antibiotic sensitive Escherichia coli 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003263 name: Antibiotic sensitive Mycobacteroides abscessus 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptible to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003264 name: Aminoglycosides sensitive Mycobacteroides abscessus 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptible to antibiotics." [] is_a: ARO:3003263 ! Antibiotic sensitive Mycobacteroides abscessus 16S rRNA [Term] id: ARO:3003265 name: Amikacin sensitive Mycobacteroides abscessus 16S rRNA mutation namespace: antibiotic_resistance def: "Sensitive form of 16s susceptible to antibiotics." [] is_a: ARO:3003264 ! Aminoglycosides sensitive Mycobacteroides abscessus 16S rRNA [Term] id: ARO:3003272 name: daptomycin resistant cls namespace: antibiotic_resistance def: "Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Current known mutations on the enzyme confer resistance to daptomycin." [PMID:9370333, PMID:23114777] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: derives_from ARO:3003274 ! antibiotic sensitive cls synonym: "cardiolipin synthetase" EXACT [] [Term] id: ARO:3003273 name: cell membrane component enzymes targeted by antibiotic namespace: antibiotic_resistance def: "Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive." [] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3003274 name: antibiotic sensitive cls namespace: antibiotic_resistance def: "Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. The inactivation of this enzyme by antibiotics leads to cell death." [] is_a: ARO:3003273 ! cell membrane component enzymes targeted by antibiotic [Term] id: ARO:3003275 name: Daptomycin sensitive cardiolipin synthetase namespace: antibiotic_resistance def: "Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Mutations on the enzyme confers resistance to Daptomycin." [PMID:21899450] is_a: ARO:3003274 ! antibiotic sensitive cls relationship: targeted_by ARO:3000035 ! lipopeptide antibiotic relationship: targeted_by_antibiotic ARO:0000068 ! daptomycin [Term] id: ARO:3003276 name: antibiotic resistant rpoB namespace: antibiotic_resistance def: "RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. Mutations in rpoB gene confers antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3003277 ! antibiotic sensitive beta-subunit of RNA polymerase (rpoB) synonym: "RNA polymerase beta subunit" EXACT [] [Term] id: ARO:3003277 name: antibiotic sensitive beta-subunit of RNA polymerase (rpoB) namespace: antibiotic_resistance def: "RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. This enzyme can be inactivated by antibiotics leading to cell death." [] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic relationship: targeted_by ARO:3000035 ! lipopeptide antibiotic relationship: targeted_by ARO:3000157 ! rifamycin antibiotic [Term] id: ARO:3003278 name: daptomycin sensitive beta-subunit of RNA polymerase (rpoB) namespace: antibiotic_resistance def: "Daptomycin binds to the cytoplasmic membrane of Gram-positive. It's lipopeptide tail servers as a ion channel for potassium. This causes a rapid depolarization that result in failures in DNA/RNA/Protein synthesis. Eventually cell death." [PMID:20837752] is_a: ARO:3003277 ! antibiotic sensitive beta-subunit of RNA polymerase (rpoB) relationship: targeted_by ARO:3000035 ! lipopeptide antibiotic relationship: targeted_by_antibiotic ARO:0000068 ! daptomycin [Term] id: ARO:3003279 name: antibiotic resistant liaFSR system namespace: antibiotic_resistance def: "The liaFSR system regulates the cell envelope stress response. It is transcriptionally activated by exposure to alkaline shock, detergents, and particularly antibiotics with lipid II inhibition properties." [PMID:19251860] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3003280 name: antibiotic sensitive mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in this enzyme can confer additional resistances." [PMID:20498310, PMID:16723576] is_a: ARO:3003273 ! cell membrane component enzymes targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000068 ! daptomycin [Term] id: ARO:3003281 name: antibiotic sensitive pgsA namespace: antibiotic_resistance def: "pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. Inhibition of this enzyme leads to cell death via the inability to form the plasma membrane." [PMID:21709092] is_a: ARO:3003273 ! cell membrane component enzymes targeted by antibiotic relationship: targeted_by_antibiotic ARO:0000068 ! daptomycin [Term] id: ARO:3003283 name: Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin namespace: antibiotic_resistance def: "Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin." [PMID:19520715, PMID:8870258, PMID:11796356, PMID:11474030, PMID:12454132, PMID:9003625, PMID:10645439, PMID:28904673, PMID:17360809, PMID:18653964, PMID:8095569, PMID:15184414, PMID:7840574, PMID:15047531, PMID:7914261, PMID:25427352, PMID:19547874, PMID:17108078, PMID:10722516, PMID:18294243, PMID:18600483, PMID:17970586, PMID:10423225, PMID:21300839, PMID:11136757, PMID:10074552, PMID:19721079, PMID:10921994, PMID:15728936, PMID:22708343, PMID:15814606, PMID:31100498, PMID:8027320] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "Mtub_rpoB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3003284 name: Mycobacterium leprae rpoB mutations conferring resistance to rifampicin namespace: antibiotic_resistance def: "Point mutations that occurs in Mycobacterium leprae rpoB resulting in resistance to rifampicin." [PMID:15603834] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "Mlep_rpoB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3003285 name: Staphylococcus aureus rpoB mutants conferring resistance to rifampicin namespace: antibiotic_resistance def: "Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to rifampicin." [PMID:10543773] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "Saur_rpoB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3003287 name: Staphylococcus aureus rpoB mutants conferring resistance to daptomycin namespace: antibiotic_resistance def: "Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to daptomycin." [PMID:16723576, PMID:20837752] is_a: ARO:3003090 ! daptomycin resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Saur_rpoB_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003288 name: Escherichia coli rpoB mutants conferring resistance to rifampicin namespace: antibiotic_resistance def: "Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin." [PMID:3050121, PMID:31992637] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "Ecol_rpoB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3003289 name: antibiotic resistant rpoC namespace: antibiotic_resistance def: "RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta prime subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. Mutations in rpoC gene confers antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3003429 ! antibiotic sensitive beta-prime subunit of RNA polymerase (rpoC) synonym: "RNA polymerase beta-prime subunit" EXACT [] [Term] id: ARO:3003290 name: daptomycin-resistant beta prime subunit of RNA polymerase (rpoC) namespace: antibiotic_resistance def: "Daptomycin resistant RNA polymerases include amino acids substitutions which alter the binding affinity of daptomycin to the protein, resulting in antibiotic resistance." [] is_a: ARO:3003289 ! antibiotic resistant rpoC relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: derives_from ARO:3003429 ! antibiotic sensitive beta-prime subunit of RNA polymerase (rpoC) [Term] id: ARO:3003291 name: Staphylococcus aureus rpoC conferring resistance to daptomycin namespace: antibiotic_resistance def: "Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin." [PMID:16723576] is_a: ARO:3003290 ! daptomycin-resistant beta prime subunit of RNA polymerase (rpoC) relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Saur_rpoC_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003292 name: fluoroquinolone resistant gyrA namespace: antibiotic_resistance def: "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit." [PMID:22279180, PMID:12499219, PMID:22371897, PMID:1850972, PMID:9293187] is_a: ARO:3000273 ! antibiotic resistant DNA topoisomerase subunit gyrA is_a: ARO:3000452 ! fluoroquinolone resistant DNA topoisomerase relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: targeted_by_antibiotic ARO:3003780 ! nybomycin [Term] id: ARO:3003294 name: Escherichia coli gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance." [PMID:2168148, PMID:1850972, PMID:2548439, PMID:8388197, PMID:7840592, PMID:25631675] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Ecol_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003295 name: Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation of Mycobacterium tuberculosis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance." [PMID:17434825, PMID:19687244, PMID:16377674, PMID:21300839, PMID:16584301, PMID:17035499, PMID:27847014, PMID:17015625, PMID:8031045] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Mtub_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003296 name: Staphylococcus aureus gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation of Staphylococcus aureus gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance." [PMID:21996946] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Saur_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003297 name: Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation of Bartonella bacilliformis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance." [PMID:12499219] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Bbac_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003298 name: Mycobacterium leprae gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation of Mycobacterium leprae gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance." [PMID:15603834] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Mlep_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003301 name: Staphylococcus aureus gyrB conferring resistance to aminocoumarin namespace: antibiotic_resistance def: "Point mutation in Staphylococcus aureus resulting in aminocoumarin resistance." [PMID:16127057] is_a: ARO:3000479 ! aminocoumarin resistant gyrB relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000132 ! clorobiocin relationship: confers_resistance_to_antibiotic ARO:3000150 ! coumermycin A1 synonym: "Saur_gyrB_AMU" EXACT CARD_Short_Name [] [Term] id: ARO:3003302 name: Bartonella bacilliformis gyrB conferring resistance to aminocoumarin namespace: antibiotic_resistance def: "Point mutation in Bartonella bacilliformis resulting in aminocoumarin resistance." [PMID:9797224] is_a: ARO:3000479 ! aminocoumarin resistant gyrB relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000132 ! clorobiocin relationship: confers_resistance_to_antibiotic ARO:3000150 ! coumermycin A1 synonym: "Bbac_gyrA_AMU" EXACT CARD_Short_Name [] [Term] id: ARO:3003303 name: Escherichia coli gyrB conferring resistance to aminocoumarin namespace: antibiotic_resistance def: "Point mutation in Escherichia coli resulting in aminocoumarin resistance." [PMID:1323022] is_a: ARO:3000479 ! aminocoumarin resistant gyrB relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000132 ! clorobiocin relationship: confers_resistance_to_antibiotic ARO:3000150 ! coumermycin A1 synonym: "Ecol_gyrB_AMU" EXACT CARD_Short_Name [] [Term] id: ARO:3003304 name: Mycobacterium leprae gyrB conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Mycobacterium leprae gyrB resulting in fluoroquinolone resistance." [PMID:23071850] is_a: ARO:3000864 ! fluoroquinolone resistant gyrB relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Mlep_gyrB_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003305 name: Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Ureaplasma urealyticum resulting in fluoroquinolone resistance." [PMID:25645833, PMID:27884651] is_a: ARO:3000864 ! fluoroquinolone resistant gyrB relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Uure_gyrB_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003306 name: Morganella morganii gyrB conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Morganella morganii resulting in fluoroquinolone resistance." [PMID:25106550] is_a: ARO:3000864 ! fluoroquinolone resistant gyrB relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Mmor_gyrB_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003307 name: Salmonella serovars gyrB conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Salmonella serovars resulting in fluoroquinolone resistance." [PMID:19104017] is_a: ARO:3000864 ! fluoroquinolone resistant gyrB relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Sser_gyrB_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003308 name: Escherichia coli parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance." [PMID:25631675] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Ecol_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003309 name: Ureaplasma urealyticum parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Ureaplasma urealyticum parC resulting in fluoroquinolone resistance." [PMID:25645833, PMID:27884651] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Uure_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003310 name: Mycoplasma hominis parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Mycoplasma hominis parC resulting in fluoroquinolone resistance." [PMID:24948939] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Mhom_23S_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003311 name: Streptococcus pneumoniae parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Streptococcus pneumoniae parC resulting in fluoroquinolone resistance." [PMID:8913454] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Spne_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003312 name: Staphylococcus aureus parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Staphylococcus aureus parC resulting in fluoroquinolone resistance." [PMID:21996946] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Saur_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003313 name: fluoroquinolone resistant parE namespace: antibiotic_resistance def: "ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance." [] is_a: ARO:3000115 ! antibiotic resistant DNA topoisomerase subunit parE is_a: ARO:3000452 ! fluoroquinolone resistant DNA topoisomerase relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: derives_from ARO:3003430 ! fluoroquinolone sensitive parE [Term] id: ARO:3003314 name: Staphylococcus aureus parE conferring resistance to aminocoumarin namespace: antibiotic_resistance def: "Point mutation in Staphylococcus aureus parE resulting in aminocoumarin resistance." [PMID:16127057] is_a: ARO:3000457 ! aminocoumarin resistant parE relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000132 ! clorobiocin relationship: confers_resistance_to_antibiotic ARO:3000150 ! coumermycin A1 synonym: "Saur_parE_AMU" EXACT CARD_Short_Name [] synonym: "grlB" EXACT [] [Term] id: ARO:3003315 name: Staphylococcus aureus parE conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Staphylococcus aureus parE resulting in fluoroquinolones resistance." [PMID:21996946] is_a: ARO:3003313 ! fluoroquinolone resistant parE relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Saur_parE_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003316 name: Escherichia coli parE conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Escherichia coli parE resulting in fluoroquinolones resistance." [PMID:25631675] is_a: ARO:3003313 ! fluoroquinolone resistant parE relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Ecol_parE_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003317 name: Salmonella serovars parE conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance." [PMID:19104017] is_a: ARO:3003313 ! fluoroquinolone resistant parE relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Sser_parE_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003318 name: Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin namespace: antibiotic_resistance def: "Intrinsically aminocoumarin-resistant parY variant found in Streptomyces, an aminocoumarin-producing genus." [PMID:14993313] is_a: ARO:3000480 ! aminocoumarin resistant parY relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000132 ! clorobiocin relationship: confers_resistance_to_antibiotic ARO:3000150 ! coumermycin A1 synonym: "Sris_parY_AMU" EXACT CARD_Short_Name [] [Term] id: ARO:3003319 name: Staphylococcus aureus mprF with mutation conferring resistance to daptomycin namespace: antibiotic_resistance def: "Point mutations that occur within Staphylococcus aureus mprF gene resulting in resistance to daptomycin." [PMID:22238576, PMID:16723576, PMID:26055370, PMID:20498310] is_a: ARO:3003091 ! daptomycin resistant mprF relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Saur_mprF_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003323 name: Staphylococcus aureus pgsA mutations conferring resistance to daptomycin namespace: antibiotic_resistance def: "Point mutations that occur within Staphylococcus aureus pgsA gene resulting in resistance to daptomycin." [PMID:22238576] is_a: ARO:3003080 ! daptomycin resistant pgsA relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Saur_pgsA_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003324 name: Bacillus subtilis mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Additionally, large-scale mutations causing loss of function of the gene result in increased susceptibility to daptomycin." [PMID:21709092, PMID:19915718, PMID:19164152] is_a: ARO:3000863 ! defensin resistant mprF relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "Bsub_mprF" EXACT CARD_Short_Name [] [Term] id: ARO:3003325 name: Mycobacterium tuberculosis variant bovis embB with mutation conferring resistance to ethambutol namespace: antibiotic_resistance def: "Point mutations that occur within Mycobacterium tuberculosis variant bovis embB gene resulting in resistance to ethambutol." [PMID:25554388] is_a: ARO:3000235 ! ethambutol resistant embB relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mbov_embB_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3003326 name: Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol namespace: antibiotic_resistance def: "Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol." [PMID:24392447, PMID:10639358, PMID:16972132, PMID:9142129, PMID:17360809, PMID:21300839, PMID:16377878, PMID:9257740, PMID:11854934, PMID:16641474, PMID:21778195] is_a: ARO:3000235 ! ethambutol resistant embB relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_embB_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3003327 name: Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol namespace: antibiotic_resistance def: "Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance." [PMID:16972132, PMID:10639358, PMID:19010731, PMID:19112008, PMID:26417605, PMID:23995136, PMID:20427375] is_a: ARO:3002706 ! ethambutol resistant embC relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_embC_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3003333 name: Escherichia coli 16S rRNA (rrsC) mutation conferring resistance to kasugamicin namespace: antibiotic_resistance def: "Point mutations in the 3' minor, 3' major, and central domains in the rrsC 16S rRNA gene of Escherichia coli can confer resistance to kasugamicin." [PMID:10512710] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:3001296 ! kasugamycin synonym: "Ecol_16rrsC_KAS" EXACT CARD_Short_Name [] [Term] id: ARO:3003356 name: Antibiotic resistant EF-Tu namespace: antibiotic_resistance def: "Sequence variants of elongation factor Tu that confer resistance to different classes of antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3000731 ! elongation factor Tu [Term] id: ARO:3003357 name: Clostridioides difficile EF-Tu mutants conferring resistance to elfamycin namespace: antibiotic_resistance def: "Sequence variants of Clostridioides difficile elongation factor Tu that confer resistance to elfamycin antibiotics." [PMID:22644023] is_a: ARO:3001312 ! elfamycin resistant EF-Tu relationship: confers_resistance_to_antibiotic ARO:3003414 ! LFF571 relationship: derives_from ARO:3000731 ! elongation factor Tu synonym: "Cdif_EFTu_ELF" EXACT CARD_Short_Name [] [Term] id: ARO:3003358 name: Escherichia coli EF-Tu mutants conferring resistance to elfamycin namespace: antibiotic_resistance def: "Sequence variants of Escherichia coli elongation factor Tu that confer resistance to elfamycin antibiotics." [] is_a: ARO:3001312 ! elfamycin resistant EF-Tu relationship: derives_from ARO:3000731 ! elongation factor Tu [Term] id: ARO:3003359 name: Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin namespace: antibiotic_resistance def: "Sequence variants of Streptomyces cinnamoneus elongation factor Tu that confer resistance to elfamycin antibiotics." [PMID:9043138] is_a: ARO:3001312 ! elfamycin resistant EF-Tu relationship: confers_resistance_to_antibiotic ARO:3001234 ! kirromycin relationship: derives_from ARO:3000731 ! elongation factor Tu synonym: "Scin_EFTu_ELF" EXACT CARD_Short_Name [] [Term] id: ARO:3003360 name: Planobispora rosea EF-Tu mutants conferring resistance to elfamycin namespace: antibiotic_resistance def: "Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to elfamycin antibiotics." [PMID:8899707] is_a: ARO:3001312 ! elfamycin resistant EF-Tu relationship: derives_from ARO:3000731 ! elongation factor Tu [Term] id: ARO:3003361 name: Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A namespace: antibiotic_resistance def: "Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A." [PMID:8899707, PMID:12370016] is_a: ARO:3003360 ! Planobispora rosea EF-Tu mutants conferring resistance to elfamycin relationship: confers_resistance_to_antibiotic ARO:3001237 ! GE2270A relationship: derives_from ARO:3000731 ! elongation factor Tu synonym: "Pros_EFTu_GE2A" EXACT CARD_Short_Name [] [Term] id: ARO:3003368 name: Escherichia coli EF-Tu mutants conferring resistance to kirromycin namespace: antibiotic_resistance def: "Sequence variants of Escherichia coli elongation factor Tu that confer resistance to kirromycin." [PMID:7525272, PMID:12370016, PMID:1552908] is_a: ARO:3003358 ! Escherichia coli EF-Tu mutants conferring resistance to elfamycin relationship: confers_resistance_to_antibiotic ARO:3001234 ! kirromycin relationship: derives_from ARO:3000731 ! elongation factor Tu synonym: "Ecol_EFTu_KIR" EXACT CARD_Short_Name [] [Term] id: ARO:3003369 name: Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin namespace: antibiotic_resistance def: "Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin." [PMID:7957075] is_a: ARO:3003358 ! Escherichia coli EF-Tu mutants conferring resistance to elfamycin relationship: confers_resistance_to_antibiotic ARO:3000586 ! pulvomycin relationship: derives_from ARO:3000731 ! elongation factor Tu synonym: "Ecol_EFTu_PLV" EXACT CARD_Short_Name [] [Term] id: ARO:3003370 name: Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa namespace: antibiotic_resistance def: "Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa." [PMID:10610785] is_a: ARO:3003358 ! Escherichia coli EF-Tu mutants conferring resistance to elfamycin relationship: confers_resistance_to_antibiotic ARO:3001242 ! enacyloxin IIa relationship: derives_from ARO:3000731 ! elongation factor Tu synonym: "Ecol_EFTu_ENC" EXACT CARD_Short_Name [] [Term] id: ARO:3003372 name: Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutations in the 3' major domain of the rrsH 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin." [PMID:6330677] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Ecol_16rrsH_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003373 name: Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance namespace: antibiotic_resistance def: "AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance." [PMID:12936981, PMID:25182649] is_a: ARO:3000702 ! acrR relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline synonym: "Kpne_acrR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3003374 name: Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance namespace: antibiotic_resistance def: "AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance." [PMID:12121946] is_a: ARO:3000702 ! acrR relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "Kaer_acrR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3003376 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin." [PMID:8127669, PMID:2447957, PMID:7885842] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Ecol_16rrsB_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003377 name: Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutations in the 3' major domain of helix 35, in the rrnB gene operon for 16S rRNA of Escherichia coli can confer resistance to spectinomycin." [PMID:16269538] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Ecol_16S_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003378 name: Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline namespace: antibiotic_resistance def: "MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB." [PMID:12027588, PMID:9333027, PMID:8807064, PMID:9687412, PMID:10760140, PMID:8550435] is_a: ARO:3000718 ! marR relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "Ecol_MarR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3003379 name: Salmonella enterica ramR mutants namespace: antibiotic_resistance def: "RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA." [PMID:19104017, PMID:19270312, PMID:18443112, PMID:19778917] is_a: ARO:3000824 ! ramR relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Sent_ramR" EXACT CARD_Short_Name [] [Term] id: ARO:3003380 name: Klebsiella pneumoniae ramR mutants namespace: antibiotic_resistance def: "RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA." [PMID:25182649] is_a: ARO:3000824 ! ramR relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline synonym: "Kpne_ramR" EXACT CARD_Short_Name [] [Term] id: ARO:3003381 name: Escherichia coli soxR with mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps." [PMID:21226770, PMID:11302826, PMID:15980345] is_a: ARO:3000836 ! soxR relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid synonym: "Ecol_soxR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3003382 name: Salmonella enterica soxR with mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression of many multidrug efflux pumps." [PMID:11302826, PMID:19104017] is_a: ARO:3000836 ! soxR relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Sent_soxR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3003383 name: Salmonella serovars soxS with mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability." [PMID:19104017] is_a: ARO:3000837 ! soxS relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Sent_soxS_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3003385 name: Klebsiella aerogenes Omp36 namespace: antibiotic_resistance def: "Mutant forms of the porin Omp36 result in reduced permeability to antibiotics." [PMID:15081418] is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3004726 ! cefpirome synonym: "Kaer_Omp36" EXACT CARD_Short_Name [] [Term] id: ARO:3003386 name: Escherichia coli folP with mutation conferring resistance to sulfonamides namespace: antibiotic_resistance def: "Point mutations in Escherichia coli dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance." [PMID:9449266] is_a: ARO:3003415 ! sulfonamide resistant dihydropteroate synthase folP relationship: confers_resistance_to_antibiotic ARO:3000324 ! sulfadiazine relationship: confers_resistance_to_antibiotic ARO:3000325 ! sulfadimidine relationship: confers_resistance_to_antibiotic ARO:3000327 ! sulfadoxine relationship: confers_resistance_to_antibiotic ARO:3000329 ! sulfamethoxazole relationship: confers_resistance_to_antibiotic ARO:3000330 ! sulfisoxazole relationship: confers_resistance_to_antibiotic ARO:3000683 ! sulfacetamide relationship: confers_resistance_to_antibiotic ARO:3000684 ! mafenide relationship: confers_resistance_to_antibiotic ARO:3000698 ! sulfasalazine relationship: confers_resistance_to_antibiotic ARO:3000699 ! sulfamethizole synonym: "Ecol_folP_SLF" EXACT CARD_Short_Name [] [Term] id: ARO:3003387 name: Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides namespace: antibiotic_resistance def: "Point mutations in Streptococcus pyogenes dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance." [PMID:9593127] is_a: ARO:3003415 ! sulfonamide resistant dihydropteroate synthase folP relationship: confers_resistance_to_antibiotic ARO:3000324 ! sulfadiazine relationship: confers_resistance_to_antibiotic ARO:3000325 ! sulfadimidine relationship: confers_resistance_to_antibiotic ARO:3000327 ! sulfadoxine relationship: confers_resistance_to_antibiotic ARO:3000329 ! sulfamethoxazole relationship: confers_resistance_to_antibiotic ARO:3000330 ! sulfisoxazole relationship: confers_resistance_to_antibiotic ARO:3000683 ! sulfacetamide relationship: confers_resistance_to_antibiotic ARO:3000684 ! mafenide relationship: confers_resistance_to_antibiotic ARO:3000698 ! sulfasalazine relationship: confers_resistance_to_antibiotic ARO:3000699 ! sulfamethizole synonym: "Spyo_folP_SLF" EXACT CARD_Short_Name [] [Term] id: ARO:3003388 name: dapsone resistant dihydropteroate synthase folP namespace: antibiotic_resistance def: "Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Thus acts as a competitive inhibitor of folP. Point mutation within the folP gene results in lowered affinity of dapsone for folP." [] is_a: ARO:3000226 ! antibiotic resistant folP relationship: confers_resistance_to_drug_class ARO:3003401 ! sulfone antibiotic relationship: derives_from ARO:3000744 ! antibiotic sensitive dihydropteroate synthase [Term] id: ARO:3003389 name: Mycobacterium leprae folP with mutation conferring resistance to dapsone namespace: antibiotic_resistance def: "Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Point mutation within the Mycobacterium leprae folP gene results in lowered affinity of dapsone for folP." [PMID:11709358, PMID:15603834, PMID:21115799] is_a: ARO:3003388 ! dapsone resistant dihydropteroate synthase folP relationship: confers_resistance_to_antibiotic ARO:3003412 ! dapsone synonym: "Mlep_folP_DAO" EXACT CARD_Short_Name [] [Term] id: ARO:3003390 name: Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics namespace: antibiotic_resistance def: "The Escherichia coli ompF (oprF) is a nonspecific porin channel involved in the membrane translocation of small hydrophilic molecules, including and especially beta-lactam antibiotics. Mutations in ompF can decrease diffusion of antibiotics across the cellular membrane, thereby decreasing overall susceptibility through absence of porin function." [PMID:10639355] is_a: ARO:3000265 ! porin OmpF relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime synonym: "Ecol_ompF_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3003392 name: Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent." [PMID:8585728, PMID:16870753, PMID:22808802, PMID:24626681, PMID:24184004, PMID:36635309, PMID:10645439, PMID:26251830, PMID:34642828, PMID:26157154, PMID:14638486, PMID:20054829, PMID:25093512, PMID:21330112, PMID:23744165, PMID:19520719, PMID:18508939, PMID:31100498, PMID:7798673, PMID:20211896, PMID:26092854, PMID:24468786, PMID:28904673, PMID:30583053] is_a: ARO:3003416 ! isoniazid resistant katG relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_katG_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3003393 name: Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by isoniazid. mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis." [PMID:16495272, PMID:30583053, PMID:8284673, PMID:9728546, PMID:14638486, PMID:7637495, PMID:23539241, PMID:22808802, PMID:21300839, PMID:16870753] is_a: ARO:3004874 ! isoniazid resistant inhA relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_inhA_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3003394 name: Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide namespace: antibiotic_resistance def: "pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity, resulting in pyrazinamide resistance." [PMID:17360809, PMID:17596354, PMID:10390239, PMID:11641519, PMID:9056006, PMID:10681313, PMID:10471589, PMID:10813147, PMID:31910878, PMID:11429043, PMID:21300839, PMID:9055989, PMID:36209317, PMID:25336456, PMID:11083630, PMID:10390238, PMID:11158123, PMID:9692180, PMID:19234602] is_a: ARO:3003418 ! Pyrazinamide resistant pncA relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_pncA_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3003395 name: Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin namespace: antibiotic_resistance def: "Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer streptomycin resistance by disrupting interactions between 16S rRNA and streptomycin." [PMID:17238915, PMID:22943573, PMID:8849220, PMID:7934937, PMID:7968530, PMID:15305490] is_a: ARO:3003419 ! antibiotic-resistant rpsL relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Mtub_rpsL_STR" EXACT CARD_Short_Name [] [Term] id: ARO:3003396 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to gentamicin C." [PMID:11502507] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C synonym: "Ecol_16S_GENC" EXACT CARD_Short_Name [] [Term] id: ARO:3003397 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to G418 namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to G418." [PMID:11502507] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:3000653 ! G418 synonym: "Ecol_16S_G418" EXACT CARD_Short_Name [] [Term] id: ARO:3003398 name: undecaprenyl pyrophosphate related proteins namespace: antibiotic_resistance def: "Undecaprenyl phosphate is a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope. Antibiotics that targets this compound or proteins associated with the production of this compound leads to cell death." [PMID:17660416] is_a: ARO:3000012 ! protein(s) conferring antibiotic resistance via molecular bypass relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003399 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to kanamycin A namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to kanamycin A." [PMID:11502507] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Ecol_16rrsB_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3003401 name: sulfone antibiotic namespace: antibiotic_resistance def: "A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium laprae. Its mechanism of action involves inhibition of folic acid synthesis in susceptible organisms." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3003402 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to neomycin." [PMID:11502507] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin synonym: "Ecol_16rrsB_NEO" EXACT CARD_Short_Name [] [Term] id: ARO:3003403 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to paromomycin." [PMID:11502507] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:3000657 ! paromomycin synonym: "Ecol_16rrsB_PAR" EXACT CARD_Short_Name [] [Term] id: ARO:3003405 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin namespace: antibiotic_resistance def: "Point mutations in the 5' domain of helix 18, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin." [PMID:3054810] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Ecol_16rrsB_STR" EXACT CARD_Short_Name [] [Term] id: ARO:3003406 name: Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin namespace: antibiotic_resistance def: "Point mutations in the 5' domain of helix 18, in the rrnB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin." [PMID:16269538] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Ecol_16S_STR" EXACT CARD_Short_Name [] [Term] id: ARO:3003408 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tobramycin." [PMID:11502507] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "Ecol_16rrsB_TOB" EXACT CARD_Short_Name [] [Term] id: ARO:3003410 name: Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline namespace: antibiotic_resistance def: "Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline." [PMID:9661007] is_a: ARO:3003669 ! 16S rRNA with mutation conferring resistance to tetracycline derivatives relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "Ecol_16rrsB_TET" EXACT CARD_Short_Name [] [Term] id: ARO:3003411 name: Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline namespace: antibiotic_resistance def: "Point mutations in the 3' major domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline." [PMID:16269538] is_a: ARO:3003669 ! 16S rRNA with mutation conferring resistance to tetracycline derivatives relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "Ecol_16S_TET" EXACT CARD_Short_Name [] [Term] id: ARO:3003412 name: dapsone namespace: antibiotic_resistance def: "Dapsone is a sulfone in which it inhibits folic acid synthesis, such as the dihydropteroate synthase." [] is_a: ARO:3003401 ! sulfone antibiotic synonym: "diaminodiphenyl sulfone" EXACT [] xref: pubchem.compound:2955 [Term] id: ARO:3003413 name: pyrazinamide namespace: antibiotic_resistance def: "Pyrazinamide is an antimycobacterial. It is highly specific and active only against Mycobacterium tuberculosis. This compound is a prodrug and needs to be activated inside the cell. It interferes with the bacterium's ability to synthesize new fatty acids, causing cell death." [PMID:26104205] is_a: ARO:3007155 ! pyrazine antibiotic xref: pubchem.compound:1046 [Term] id: ARO:3003414 name: LFF571 namespace: antibiotic_resistance def: "LFF571 is a novel semi-synthetic thiopeptide antibiotic derived from GE2270. It has been shown to possess potent in vitro and in vivo activity against Gram-positive bacteria. It is hypothesized that it a translation inhibitor leading to cell death." [PMID:22644023] is_a: ARO:3001309 ! cyclic thiazolyl peptide elfamycin xref: pubchem.compound:42638236 [Term] id: ARO:3003415 name: sulfonamide resistant dihydropteroate synthase folP namespace: antibiotic_resistance def: "Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance." [] is_a: ARO:3000226 ! antibiotic resistant folP relationship: confers_resistance_to_drug_class ARO:3000282 ! sulfonamide antibiotic [Term] id: ARO:3003416 name: isoniazid resistant katG namespace: antibiotic_resistance def: "Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. It is a catalase-peroxidases that catalyzes the activation of isoniazid. Mutations that arises within this protein cause changes that results in the inability for katG to activate antibiotics, conferring resistance." [] is_a: ARO:3004266 ! antibiotic resistant katG relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic synonym: "catalase-peroxidases" EXACT [] [Term] id: ARO:3003417 name: antibiotic resistant inhA namespace: antibiotic_resistance def: "inhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. It is inhibited by isoniazid. Mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis." [PMID:8284673] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3003426 ! antibiotic sensitive inhA synonym: "enoyl-acyl carrier reductase" EXACT [] [Term] id: ARO:3003418 name: Pyrazinamide resistant pncA namespace: antibiotic_resistance def: "pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide to pyrazinoic acid. Mutations arise within the pncA gene that caused the loss of pyrazinamidase activity is the major mechanism of antibiotic resistance." [PMID:9055989] is_a: ARO:3004267 ! antibiotic resistant pncA relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic synonym: "nicotinamidase" EXACT [] [Term] id: ARO:3003419 name: antibiotic-resistant rpsL namespace: antibiotic_resistance def: "Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic relationship: derives_from ARO:3003431 ! antibiotic sensitive Ribosomal protein S12 (rpsL) synonym: "Ribosomal protein S12" EXACT [] [Term] id: ARO:3003420 name: antibiotic resistant pgsA namespace: antibiotic_resistance def: "pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3003281 ! antibiotic sensitive pgsA synonym: "phosphatidylglycerophosphate synthetase" EXACT [] [Term] id: ARO:3003421 name: antibiotic resistant mprF namespace: antibiotic_resistance def: "Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins)." [] is_a: ARO:3003580 ! gene altering cell wall charge synonym: "Phosphatidylglycerol lysyltransferase" EXACT [] [Term] id: ARO:3003422 name: antibiotic resistant aftA namespace: antibiotic_resistance def: "Arabinofuranosyltransferase is involved in the biosynthesis of the arabinogalactan region of the mAGP complex, an essential component of the mycobacterial cell wall." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3000725 ! antibiotic sensitive aftA [Term] id: ARO:3003425 name: antibiotic resistant dihydrofolate reductase namespace: antibiotic_resistance def: "Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis." [] is_a: ARO:3000381 ! antibiotic target replacement protein [Term] id: ARO:3003426 name: antibiotic sensitive inhA namespace: antibiotic_resistance def: "inhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis." [] is_a: ARO:3000872 ! antibiotic sensitive enoyl-acyl carrier reductase relationship: targeted_by_antibiotic ARO:3000520 ! isoniazid [Term] id: ARO:3003428 name: porin proteins permeable to antibiotics namespace: antibiotic_resistance def: "Porin proteins permeable to antibiotics." [] is_a: ARO:3000708 ! antibiotic target [Term] id: ARO:3003429 name: antibiotic sensitive beta-prime subunit of RNA polymerase (rpoC) namespace: antibiotic_resistance def: "RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-prime subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. This enzyme can be inactivated by antibiotics leading to cell death." [] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic [Term] id: ARO:3003430 name: fluoroquinolone sensitive parE namespace: antibiotic_resistance def: "ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance." [] is_a: ARO:3003259 ! antibiotic sensitive DNA topoisomerase subunit parE [Term] id: ARO:3003431 name: antibiotic sensitive Ribosomal protein S12 (rpsL) namespace: antibiotic_resistance def: "Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. It is targeted and inhibited by streptomycin." [] is_a: ARO:3000711 ! protein synthesis machinery targeted by antibiotic relationship: targeted_by ARO:0000016 ! aminoglycoside antibiotic relationship: targeted_by_antibiotic ARO:0000040 ! streptomycin [Term] id: ARO:3003436 name: Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin namespace: antibiotic_resistance def: "Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to kanamycin." [PMID:9574680, PMID:9244267] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Mtub_16S_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3003437 name: Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to viomycin namespace: antibiotic_resistance def: "Peptide antibiotics inhibit protein synthesis. Resistance to viomycin can be caused by an altered RNA molecule in the 16S ribosomal subunit." [PMID:9244267] is_a: ARO:3003667 ! 16s rRNA with mutation conferring resistance to peptide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000018 ! viomycin synonym: "Mtub_16S_VIO" EXACT CARD_Short_Name [] [Term] id: ARO:3003438 name: Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A namespace: antibiotic_resistance def: "Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to GE2270A." [PMID:7989561] is_a: ARO:3003875 ! Enterococcus faecium EF-Tu mutants conferring resistance to elfamycin relationship: confers_resistance_to_antibiotic ARO:3001237 ! GE2270A relationship: derives_from ARO:3000731 ! elongation factor Tu synonym: "Efac_EFTu_GE2A" EXACT CARD_Short_Name [] [Term] id: ARO:3003439 name: antibiotic sensitive RNA polymerase switch region namespace: antibiotic_resistance def: "The switch region is a structural element that mediates conformational changes and contacts required for RNAP to load DNA into the RNAP active-center cleft during transcription initiation. The switch region is located at the base of the RNAP clamp and serves as the hinge that mediates opening of the RNAP clamp to load DNA into the RNAP active-center cleft and mediates closing of the RNAP clamp to retain DNA in the RNAP active-center cleft." [PMID:21862392] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic relationship: targeted_by ARO:3001318 ! macrocyclic antibiotic relationship: targeted_by_antibiotic ARO:3001319 ! fidaxomicin [Term] id: ARO:3003440 name: mecB namespace: antibiotic_resistance def: "A foreign PBP2 acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams." [PMID:24302651] is_a: ARO:3001208 ! methicillin resistant PBP2 relationship: confers_resistance_to_antibiotic ARO:0000015 ! methicillin synonym: "PBP2B" EXACT [] synonym: "mecB" EXACT CARD_Short_Name [] [Term] id: ARO:3003441 name: cfrA namespace: antibiotic_resistance def: "CfrA is a chloramphenicol-florfenicol resistance gene and methyltransferase enzyme. Methylation of position 8 of A2503 in 23S rRNA confers resistance to chloramphenicol antibiotics first identified by Schwarz 2000 as cfr from Mammaliicoccus sciuri. Additional Oxazolidinone resistance mediated by the cfr gene in a human isolated was first reported from Colombia in linezolid- and methicillin-resistant Staphylococcus aureus." [PMID:28663118, PMID:15700955, PMID:18174304, PMID:10952608, PMID:17145796] is_a: ARO:3004607 ! Cfr Group relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin synonym: "cfr" EXACT [] synonym: "cfr(A)" EXACT [] synonym: "cfrA" EXACT CARD_Short_Name [] [Term] id: ARO:3003443 name: Antibiotic resistant tlyA namespace: antibiotic_resistance def: "tlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA." [PMID:15673735] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3000857 ! 16S ribosomal RNA methyltransferase relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic relationship: derives_from ARO:3003476 ! antibiotic sensitive tlyA [Term] id: ARO:3003445 name: Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides namespace: antibiotic_resistance def: "Specific mutations that arise in Mycobacterium tuberculosis tlyA resulting in aminoglycosides resistance." [PMID:15673735] is_a: ARO:3003443 ! Antibiotic resistant tlyA relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:3003993 ! capreomycin synonym: "Mtub_tlyA_AMG" EXACT CARD_Short_Name [] [Term] id: ARO:3003446 name: Antibiotic resistant iniA namespace: antibiotic_resistance def: "iniA, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell." [PMID:15752203] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance [Term] id: ARO:3003447 name: Ethambutol resistant iniA namespace: antibiotic_resistance def: "Mutations that occurs on the iniA genes resulting in the resistance to ethambutol." [] is_a: ARO:3003446 ! Antibiotic resistant iniA relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic [Term] id: ARO:3003448 name: Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol namespace: antibiotic_resistance def: "Specific mutations in Mycobacterium tuberculosis iniA resulting in resistance to ethambutol." [PMID:10639358, PMID:12654653] is_a: ARO:3003447 ! Ethambutol resistant iniA relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_iniA_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3003449 name: Antibiotic resistant iniC namespace: antibiotic_resistance def: "iniC, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell." [PMID:15752203] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance [Term] id: ARO:3003450 name: Ethambutol resistant iniC namespace: antibiotic_resistance def: "Mutations that occurs on the iniC genes resulting in the resistance to ethambutol." [] is_a: ARO:3003449 ! Antibiotic resistant iniC relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic [Term] id: ARO:3003451 name: Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol namespace: antibiotic_resistance def: "Specific mutations that occurs on Mycobacterium tuberculosis iniC causing it to be ethambutol resistant." [PMID:12654653, PMID:16272473, PMID:10639358] is_a: ARO:3003450 ! Ethambutol resistant iniC relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_iniC_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3003452 name: ethambutol resistant embA namespace: antibiotic_resistance def: "Mutations that occurs on the embA genes resulting in the resistance to ethambutol." [] is_a: ARO:3005005 ! antibiotic-resistant emb arabinosyltransferase relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic relationship: derives_from ARO:3000764 ! antibiotic sensitive embA [Term] id: ARO:3003453 name: Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol namespace: antibiotic_resistance def: "Specific mutations that occurs on Mycobacterium tuberculosis embA leading to the lowered affinity of ethambutol to embA." [PMID:10639358] is_a: ARO:3003452 ! ethambutol resistant embA relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_embA_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3003454 name: ethambutol resistant embR namespace: antibiotic_resistance def: "Mutations that occurs on the embR genes resulting in the resistance to ethambutol." [] is_a: ARO:3005005 ! antibiotic-resistant emb arabinosyltransferase relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic relationship: derives_from ARO:3003473 ! Antibiotic sensitive embR [Term] id: ARO:3003455 name: Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol namespace: antibiotic_resistance def: "Point mutation in the M.tuberculosis embR results in increased resistance to ethambutol." [PMID:10639358] is_a: ARO:3003454 ! ethambutol resistant embR relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_embR_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3003456 name: antibiotic resistant ethA namespace: antibiotic_resistance def: "Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. It is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species." [PMID:10869356] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3003475 ! Antibiotic sensitive ethA synonym: "FAD-containing monooxygenase" EXACT [] [Term] id: ARO:3003457 name: ethionamide resistant ethA namespace: antibiotic_resistance def: "Mutations that occurs on the ethA genes resulting in the inability to catalyzes the oxidation of ethionamide (ETH) to the corresponding sulfoxide (the active drug)." [] is_a: ARO:3003456 ! antibiotic resistant ethA relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3003458 name: Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide namespace: antibiotic_resistance def: "Specific mutations that occurs on Mycobacterium tuberculosis ethA causing it to be ethionamide resistant." [PMID:14638486, PMID:10944230, PMID:28993337] is_a: ARO:3003457 ! ethionamide resistant ethA relationship: confers_resistance_to_antibiotic ARO:3003474 ! ethionamide synonym: "Mtub_ethA_ETO" EXACT CARD_Short_Name [] [Term] id: ARO:3003459 name: Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Mycobacterium tuberculosis gyrB resulting in fluoroquinolone resistance." [PMID:22761889, PMID:16377674] is_a: ARO:3000864 ! fluoroquinolone resistant gyrB relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Mtub_gyrB_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003460 name: antibiotic resistant ndh namespace: antibiotic_resistance def: "ndh is a NADH oxidase. It participates in antibiotic resistance by diminishing NADH oxidation and consequently causes an increase in NADH concentration and depletion of NAD+. This alteration of the NADH/NAD+ ratio prevents the peroxidation reactions required for the activation of INH, as well as the displacement of the NADH-isonicotinic acyl complex from InhA enzyme binding site." [PMID:17294000] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3003461 name: Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid namespace: antibiotic_resistance def: "Point mutations in the Mycobacterium tuberculosis ndh gene shown clinically to confer resistance to isoniazid." [PMID:26311839, PMID:26104204, PMID:17294000, PMID:30583053, PMID:24855126, PMID:26369965] is_a: ARO:3003460 ! antibiotic resistant ndh relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_ndh_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3003462 name: antibiotic resistant kasA namespace: antibiotic_resistance def: "kasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids." [PMID:10428945] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic relationship: derives_from ARO:3003478 ! antibiotic sensitive kasA [Term] id: ARO:3003463 name: Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid namespace: antibiotic_resistance def: "Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid, resulting in resistance." [PMID:9616124, PMID:10428945] is_a: ARO:3003462 ! antibiotic resistant kasA relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_kasA_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3003464 name: rifamycin-resistant arabinosyltransferase namespace: antibiotic_resistance def: "Arabinosyl transferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to rifampicin." [PMID:17846128] is_a: ARO:3003422 ! antibiotic resistant aftA relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic relationship: derives_from ARO:3000725 ! antibiotic sensitive aftA [Term] id: ARO:3003465 name: Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin namespace: antibiotic_resistance def: "Specific mutations that occurs on Mycobacterium tuberculosis embB causing it to be rifampicin resistant." [PMID:17846128] is_a: ARO:3003464 ! rifamycin-resistant arabinosyltransferase relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "Mtub_embB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3003466 name: antibiotic resistant gidB namespace: antibiotic_resistance def: "GidB is a m7G methyltransferase specific for 16S rRNA. Mutations within the gidB gene causes changes in the structure or 16s rRNA, leading to resistance to aminoglycosides." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3000857 ! 16S ribosomal RNA methyltransferase relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic relationship: derives_from ARO:3003477 ! antibiotic sensitive gidB synonym: "rsmG" EXACT [] [Term] id: ARO:3003470 name: Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin namespace: antibiotic_resistance def: "Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant." [PMID:31934102, PMID:31100498, PMID:18541729, PMID:17238915, PMID:21444711, PMID:32014024, PMID:21593257] is_a: ARO:3003466 ! antibiotic resistant gidB relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Mtub_gidB_STR" EXACT CARD_Short_Name [] [Term] id: ARO:3003473 name: Antibiotic sensitive embR namespace: antibiotic_resistance def: "Wildtype embR is sensitive to antibiotics. It is an arabinosyltransferase involved in lipoarabinomannan synthesis." [] is_a: ARO:3000725 ! antibiotic sensitive aftA relationship: targeted_by_antibiotic ARO:3000497 ! ethambutol [Term] id: ARO:3003474 name: ethionamide namespace: antibiotic_resistance def: "Ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis." [] is_a: ARO:3007156 ! thioamide antibiotic xref: pubchem.compound:2761171 [Term] id: ARO:3003475 name: Antibiotic sensitive ethA namespace: antibiotic_resistance def: "ethA is a monooxygenase that is able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species." [] is_a: ARO:3000716 ! mycolic acid synthesis enzyme targeted by antibiotic relationship: targeted_by_antibiotic ARO:3003474 ! ethionamide [Term] id: ARO:3003476 name: antibiotic sensitive tlyA namespace: antibiotic_resistance def: "It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA." [] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic [Term] id: ARO:3003477 name: antibiotic sensitive gidB namespace: antibiotic_resistance def: "GidB is a m7G methyltransferase specific for 16S rRNA." [PMID:17238915] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic relationship: targeted_by ARO:0000016 ! aminoglycoside antibiotic synonym: "rsmG" EXACT [] [Term] id: ARO:3003478 name: antibiotic sensitive kasA namespace: antibiotic_resistance def: "kasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids." [] is_a: ARO:3000716 ! mycolic acid synthesis enzyme targeted by antibiotic is_a: ARO:3000872 ! antibiotic sensitive enoyl-acyl carrier reductase relationship: targeted_by_antibiotic ARO:3000520 ! isoniazid [Term] id: ARO:3003479 name: tetR namespace: antibiotic_resistance def: "TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin." [PMID:3062183] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000165 ! tet(A) synonym: "tetR" EXACT CARD_Short_Name [] [Term] id: ARO:3003480 name: Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin namespace: antibiotic_resistance def: "Point mutations within the 530 loop of the 16S rRNA of Mycobacterium tuberculosis can result in resistance against streptomycin. These mutations do not directly inhibit the binding of streptomycin, but is hypothesized that they interfere with conformational perturbations that account for streptomycin's action on the ribosome." [PMID:7934937, PMID:9244267, PMID:8913445, PMID:35072512, PMID:18541729, PMID:8192448] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Mtub_16S_STR" EXACT CARD_Short_Name [] [Term] id: ARO:3003481 name: Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin namespace: antibiotic_resistance def: "Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to amikacin." [PMID:9593173] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin synonym: "Mtub_16S_AMK" EXACT CARD_Short_Name [] [Term] id: ARO:3003485 name: Chlamydophila psittaci 16S rRNA mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutation in the 16S rRNA helix 34 region of Chlamydophila psittaci can confer resistance against spectinomycin." [PMID:15980362] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Cpsi_16S_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003493 name: Pasteurella multocida 16S rRNA mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutations in the helix 34 region of 16S rRNA of Pasteurella multocida can confer resistance to spectinomycin." [PMID:17371823] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Pmul_16S_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003495 name: Neisseria gonorrhoeae 16S rRNA mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutations in the helix 34 region of 16S rRNA of Neisseria gonorrhoeae can confer resistance against spectinomycin." [PMID:10770780] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Ngon_16S_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003497 name: Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Neisseria meningitidis can confer resistance to spectinomycin." [PMID:10770780] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Nmen_16S_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003499 name: Cutibacterium acnes 16S rRNA mutation conferring resistance to tetracycline namespace: antibiotic_resistance def: "Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain for Cutibacterium acnes can result in resistance against tetracycline." [PMID:9661007] is_a: ARO:3003669 ! 16S rRNA with mutation conferring resistance to tetracycline derivatives relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "Cacn_16S_TET" EXACT CARD_Short_Name [] [Term] id: ARO:3003502 name: Borreliella burgdorferi 16S rRNA mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutations in the 3' major domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to spectinomycin." [PMID:16436695] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Bbur_16S_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003503 name: Borreliella burgdorferi 16S rRNA mutation conferring resistance to kanamycin namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to kanamycin." [PMID:16436695] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Bbur_16S_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3003504 name: Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin namespace: antibiotic_resistance def: "Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to gentamicin." [PMID:16436695] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C synonym: "Bbur_16S_GEN" EXACT CARD_Short_Name [] [Term] id: ARO:3003510 name: Helicobacter pylori 16S rRNA mutation conferring resistance to tetracycline namespace: antibiotic_resistance def: "Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain of Helicobacter pylori can result in resistance against tetracycline." [PMID:20035020, PMID:11914344, PMID:12435699, PMID:12183259] is_a: ARO:3003669 ! 16S rRNA with mutation conferring resistance to tetracycline derivatives relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "Hpyl_16S_TET" EXACT CARD_Short_Name [] [Term] id: ARO:3003511 name: Escherichia coli soxS with mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability." [PMID:25921515] is_a: ARO:3000837 ! soxS relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3007045 ! enrofloxacin synonym: "Ecol_soxS_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3003512 name: Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin." [PMID:12402084] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Sent_16S_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3003514 name: Mycobacteroides chelonae 16S rRNA mutation conferring resistance to amikacin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to amikacin." [PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin synonym: "Mche_16S_AMK" EXACT CARD_Short_Name [] [Term] id: ARO:3003515 name: Mycobacteroides chelonae 16S rRNA mutation conferring resistance to kanamycin A namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to kanamycin A." [PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Mche_16S_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3003516 name: Mycobacteroides chelonae 16S rRNA mutation conferring resistance to tobramycin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to tobramycin." [PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "Mche_16S_TOB" EXACT CARD_Short_Name [] [Term] id: ARO:3003517 name: Mycobacteroides chelonae 16S rRNA mutation conferring resistance to gentamicin C namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides chelonae can confer resistance to gentamicin C." [PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C synonym: "Mche_16S_GENC" EXACT CARD_Short_Name [] [Term] id: ARO:3003518 name: Mycobacteroides chelonae 16S rRNA mutation conferring resistance to neomycin namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to neomycin." [PMID:9607835] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin synonym: "Mche_16S_NEO" EXACT CARD_Short_Name [] [Term] id: ARO:3003520 name: Antibiotic sensitive Borreliella burgdorferi 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003521 name: Antibiotic sensitive Chlamydophila psittaci 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003522 name: Antibiotic sensitive Helicobacter pylori 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003523 name: Antibiotic sensitive Mycobacteroides chelonae 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003524 name: Antibiotic sensitive Mycolicibacterium smegmatis 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003525 name: Antibiotic sensitive Neisseria gonorrhoeae 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003526 name: Antibiotic sensitive Neisseria meningitidis 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003527 name: Antibiotic sensitive Pasteurella multocida 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003528 name: Antibiotic sensitive Cutibacterium acnes 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003529 name: Antibiotic sensitive Salmonella enterica serovar Typhimurium 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003530 name: Antibiotic sensitive Mycobacterium tuberculosis 16S rRNA namespace: antibiotic_resistance def: "Sensitive form of 16s susceptable to antibiotics." [] is_a: ARO:3000755 ! antibiotic sensitive 16S rRNA [Term] id: ARO:3003539 name: Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B namespace: antibiotic_resistance def: "Point mutations in the highly conserved helix 44 of the 16S rrsA rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site." [PMID:12709313] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:3000214 ! hygromycin B synonym: "Msme_16rrsA_HGM" EXACT CARD_Short_Name [] [Term] id: ARO:3003540 name: Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B namespace: antibiotic_resistance def: "Point mutations in the highly conserved helix 44 of the 16S rrsB rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site." [PMID:12709313] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:3000214 ! hygromycin B synonym: "Msme_16rrsB_HGM" EXACT CARD_Short_Name [] [Term] id: ARO:3003541 name: Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin namespace: antibiotic_resistance def: "Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to streptomycin." [PMID:11557484] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Msme_16rrsB_STR" EXACT CARD_Short_Name [] [Term] id: ARO:3003542 name: Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A namespace: antibiotic_resistance def: "Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A." [PMID:9244267] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Msme_16rrsB_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3003543 name: Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A namespace: antibiotic_resistance def: "Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A." [PMID:9244267] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Msme_16rrsA_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3003544 name: Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin namespace: antibiotic_resistance def: "Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to neomycin." [PMID:9244267] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin synonym: "Msme_16rrsA_NEO" EXACT CARD_Short_Name [] [Term] id: ARO:3003545 name: Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin namespace: antibiotic_resistance def: "Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to neomycin." [PMID:9244267] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin synonym: "Msme_16rrsB_NEO" EXACT CARD_Short_Name [] [Term] id: ARO:3003546 name: Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin namespace: antibiotic_resistance def: "Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to viomycin." [PMID:9244267] is_a: ARO:3003667 ! 16s rRNA with mutation conferring resistance to peptide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000018 ! viomycin synonym: "Msme_16rrsA_VIO" EXACT CARD_Short_Name [] [Term] id: ARO:3003547 name: Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin namespace: antibiotic_resistance def: "Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to viomycin." [PMID:9244267] is_a: ARO:3003667 ! 16s rRNA with mutation conferring resistance to peptide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000018 ! viomycin synonym: "Msme_16rrsB_VIO" EXACT CARD_Short_Name [] [Term] id: ARO:3003548 name: mdtN namespace: antibiotic_resistance def: "Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride." [PMID:19429622, PMID:8021163, PMID:11257026] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004101 ! MdtNOP synonym: "mdtN" EXACT CARD_Short_Name [] synonym: "sdsR" EXACT [] synonym: "yjcR" EXACT [] [Term] id: ARO:3003549 name: mdtO namespace: antibiotic_resistance def: "Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride." [PMID:19429622, PMID:11257026] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004101 ! MdtNOP synonym: "mdtO" EXACT CARD_Short_Name [] synonym: "sdsQ" EXACT [] synonym: "yjcQ" EXACT [] [Term] id: ARO:3003550 name: mdtP namespace: antibiotic_resistance def: "Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride." [PMID:19429622, PMID:11257026] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004101 ! MdtNOP synonym: "mdtP" EXACT CARD_Short_Name [] synonym: "sdsP" EXACT [] synonym: "yjcP" EXACT [] [Term] id: ARO:3003551 name: emeA namespace: antibiotic_resistance def: "A multidrug efflux pump from Enterococcus faecalis. There exist efflux activity of several antimicrobial agents such as DAPI, Hoechst 33342 and acriflavine. Efflux of DAPI via EmeA was strongly inhibited by reserpine." [PMID:12576692] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine synonym: "emeA" EXACT CARD_Short_Name [] [Term] id: ARO:3003552 name: fusB namespace: antibiotic_resistance def: "FusB encodes a 2-domain zinc-binding protein that binds the ribosomal translocase EF-G, causing it to dissociate from the ribosome. This action increases the ribosomal turnover rate and confers resistance to fusidic acid. This protein is considered a FusB-type protein." [PMID:16390458, PMID:22308410] is_a: ARO:3005086 ! Target protecting FusB-type protein conferring resistance to Fusidic acid relationship: confers_resistance_to_antibiotic ARO:3000759 ! fusidic acid synonym: "fusB" EXACT CARD_Short_Name [] [Term] id: ARO:3003553 name: CepS namespace: antibiotic_resistance def: "CEPS is a typical class C cephalosporinase found in Aeromonas sobria, first isolated from strain 163a." [PMID:11062187] is_a: ARO:3004199 ! CepS beta-lactamase synonym: "CepS" EXACT CARD_Short_Name [] [Term] id: ARO:3003554 name: tcmA namespace: antibiotic_resistance def: "Major facilitator superfamily transporter. Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients." [PMID:1592819] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3007035 ! tetracenomycin C synonym: "tcmA" EXACT CARD_Short_Name [] [Term] id: ARO:3003555 name: SHW beta-lactamase namespace: antibiotic_resistance def: "This family of sublcass B1 beta-lactamases were discovered in species of the Shewanella genus." [PMID:15772146] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3003556 name: SLB-1 namespace: antibiotic_resistance def: "This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties." [PMID:15772146] is_a: ARO:3003555 ! SHW beta-lactamase synonym: "SLB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003557 name: SFB-1 namespace: antibiotic_resistance def: "This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties." [PMID:15772146] is_a: ARO:3003555 ! SHW beta-lactamase synonym: "SFB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003558 name: y56 beta-lactamase namespace: antibiotic_resistance def: "Class A beta-lactamase found in Yersinia enterocolitica biovar 1A." [PMID:16553870] is_a: ARO:3004190 ! BlaA beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "Yent_y56" EXACT CARD_Short_Name [] [Term] id: ARO:3003559 name: cepA namespace: antibiotic_resistance def: "A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity." [PMID:7517394] is_a: ARO:3004192 ! CepA beta-lactamase synonym: "cepA" EXACT CARD_Short_Name [] [Term] id: ARO:3003561 name: Sed-1 namespace: antibiotic_resistance def: "Sed-1 is a chromosomal-encoded class A beta-lactamase identified in Citrobacter sedlakii." [PMID:11451687] is_a: ARO:3004193 ! Sed beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "Sed-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003562 name: blaF namespace: antibiotic_resistance def: "Class A beta-lactamase found in Mycolicibacterium fortuitum." [PMID:8065266] is_a: ARO:3004233 ! blaF family beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin synonym: "blaF" EXACT CARD_Short_Name [] [Term] id: ARO:3003563 name: RCP-1 namespace: antibiotic_resistance def: "RCP is a class A beta-lactamase found in Rhodopseudomonas capsulata." [PMID:2788410] is_a: ARO:3004235 ! RCP beta-lactamase synonym: "RCP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003564 name: EXO-1 namespace: antibiotic_resistance def: "Class A beta-lactamase found in Streptomyces albus G." [PMID:1540134] is_a: ARO:3004234 ! EXO beta-lactamase synonym: "ALBUS" EXACT [] synonym: "EXO-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003565 name: R39 namespace: antibiotic_resistance def: "Class A beta-lactamase found in Actinomadura R39." [PMID:2515104] is_a: ARO:3004198 ! R39 beta-lactamase synonym: "R39" EXACT CARD_Short_Name [] [Term] id: ARO:3003567 name: magainin A namespace: antibiotic_resistance def: "Magainins A are antimicrobial peptides produced by amphibians as part of their innate immune system." [PMID:2285300] is_a: ARO:3000694 ! magainin xref: pubchem.compound:16132424 [Term] id: ARO:3003568 name: Magainin B namespace: antibiotic_resistance def: "Magainin B is is a synthetic analog of magainin 1, an antimicrobial peptide." [PMID:2285300] is_a: ARO:3000694 ! magainin xref: pubchem.compound:16131332 [Term] id: ARO:3003569 name: Magainin G namespace: antibiotic_resistance def: "Magainin G is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B by the addition of an beta-alanine at the N terminal." [PMID:2285300] is_a: ARO:3000694 ! magainin xref: pubchem.compound:16132425 [Term] id: ARO:3003570 name: Magainin H namespace: antibiotic_resistance def: "Magainin H is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B with the substitution of D-alanine instead of L-alanine." [PMID:2285300] is_a: ARO:3000694 ! magainin xref: pubchem.compound:16132431 [Term] id: ARO:3003571 name: magainin 1 namespace: antibiotic_resistance def: "Magainin1 is an antimicrobial peptides produced by amphibians as part of their innate immune system. It is derived from the Xenopus laevis." [PMID:3277183] is_a: ARO:3000694 ! magainin xref: pubchem.compound:16132169 [Term] id: ARO:3003572 name: magainin 2 namespace: antibiotic_resistance def: "Magainin 2 is an antimicrobial peptides produced from Xenopus laevis skin. It induce osmotic lysis of bacteria." [PMID:3277183] is_a: ARO:3000694 ! magainin xref: pubchem.compound:16130189 [Term] id: ARO:3003573 name: LpxA namespace: antibiotic_resistance def: "The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane." [PMID:24189257, PMID:20855724] is_a: ARO:3003581 ! Acinetobacter mutant Lpx gene conferring resistance to colistin relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "LpxA" EXACT CARD_Short_Name [] [Term] id: ARO:3003574 name: LpxC namespace: antibiotic_resistance def: "The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane." [PMID:20855724, PMID:24189257] is_a: ARO:3003581 ! Acinetobacter mutant Lpx gene conferring resistance to colistin relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "LpxC" EXACT CARD_Short_Name [] [Term] id: ARO:3003575 name: LpxD namespace: antibiotic_resistance def: "The LpxD gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane." [PMID:20855724, PMID:24189257] is_a: ARO:3003581 ! Acinetobacter mutant Lpx gene conferring resistance to colistin relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "LpxD" EXACT CARD_Short_Name [] [Term] id: ARO:3003576 name: eptA namespace: antibiotic_resistance def: "PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B." [PMID:15205413] is_a: ARO:3004269 ! pmr phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B synonym: "PmrC" EXACT [] synonym: "eptA" EXACT CARD_Short_Name [] [Term] id: ARO:3003577 name: ugd namespace: antibiotic_resistance def: "PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin." [PMID:15205413, PMID:9570402] is_a: ARO:3004269 ! pmr phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B synonym: "ECK2023" EXACT [] synonym: "JW2010" EXACT [] synonym: "pagA" EXACT [] synonym: "pmrE" EXACT [] synonym: "udg" EXACT [] synonym: "ugd" EXACT CARD_Short_Name [] synonym: "yefA" EXACT [] [Term] id: ARO:3003578 name: PmrF namespace: antibiotic_resistance def: "PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58." [PMID:9570402] is_a: ARO:3004269 ! pmr phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B synonym: "PmrF" EXACT CARD_Short_Name [] synonym: "arnC" EXACT [] [Term] id: ARO:3003579 name: basRS namespace: antibiotic_resistance def: "BasRS is a two-component regulatory system. BasR is phosphorylated by BasS at high[Fe3+] levels. The BasRS system regulates the expression of pmrE, pmrF and pmrC, leading to antibiotic resistance." [PMID:24412662] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3002985 ! arnA relationship: regulates ARO:3003577 ! ugd relationship: regulates ARO:3003578 ! PmrF synonym: "pmrAB" EXACT [] [Term] id: ARO:3003580 name: gene altering cell wall charge namespace: antibiotic_resistance def: "Genes involved in alteration of the cell wall overall charge, leading to antimicrobial resistance due to reduced binding." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:3003588 ! charge alteration conferring antibiotic resistance [Term] id: ARO:3003581 name: Acinetobacter mutant Lpx gene conferring resistance to colistin namespace: antibiotic_resistance def: "These genes are involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. Mutation by absence or insertion of ISAba11 sequence is a known cause of resistance in Acinetobacter baumannii▿." [PMID:21402838, PMID:24189257] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3000012 ! protein(s) conferring antibiotic resistance via molecular bypass relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003582 name: basR namespace: antibiotic_resistance def: "Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)." [PMID:25006521] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3003579 ! basRS relationship: regulates ARO:3003576 ! eptA synonym: "basR" EXACT CARD_Short_Name [] [Term] id: ARO:3003583 name: basS namespace: antibiotic_resistance def: "Histidine protein kinase sensor Lipid A modification gene; part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)." [PMID:14507375, PMID:25006521] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3003579 ! basRS synonym: "basS" EXACT CARD_Short_Name [] synonym: "pmrB" EXACT [] [Term] id: ARO:3003585 name: Klebsiella mutant PhoP conferring antibiotic resistance to colistin namespace: antibiotic_resistance def: "A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge." [PMID:25733503] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3000834 ! phoP is_a: ARO:3003580 ! gene altering cell wall charge relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "Kleb_PhoP_CST" EXACT CARD_Short_Name [] [Term] id: ARO:3003588 name: charge alteration conferring antibiotic resistance namespace: antibiotic_resistance def: "The loss or reduction of the net negative charge within the cell wall of gram negative bacteria is a mechanism of resistance for cationic antimicrobials that depend on the negative charge for binding to the surface." [] is_a: ARO:0001001 ! antibiotic target alteration [Term] id: ARO:3003589 name: NmcA namespace: antibiotic_resistance def: "NmcA is a class A serine beta-lactamase isolated from Enterobacter cloacae." [PMID:8052644] is_a: ARO:3004195 ! NmcA beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "NmcA" EXACT CARD_Short_Name [] [Term] id: ARO:3003590 name: SHV-190 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases, not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-190" EXACT CARD_Short_Name [] [Term] id: ARO:3003591 name: SHV-191 namespace: antibiotic_resistance def: "From the Lahey list of beta-lactamases, not yet released." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-191" EXACT CARD_Short_Name [] [Term] id: ARO:3003592 name: TEM-223 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamase, not yet released." [] is_a: ARO:3000014 ! TEM beta-lactamase [Term] id: ARO:3003593 name: OXA-437 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-437" EXACT CARD_Short_Name [] [Term] id: ARO:3003594 name: OXA-438 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-438" EXACT CARD_Short_Name [] [Term] id: ARO:3003595 name: OXA-439 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-439" EXACT CARD_Short_Name [] [Term] id: ARO:3003596 name: OXA-440 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-440" EXACT CARD_Short_Name [] [Term] id: ARO:3003597 name: OXA-441 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-441" EXACT CARD_Short_Name [] [Term] id: ARO:3003598 name: OXA-442 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-442" EXACT CARD_Short_Name [] [Term] id: ARO:3003599 name: OXA-443 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007708 ! OXA-22-like beta-lactamase synonym: "OXA-443" EXACT CARD_Short_Name [] [Term] id: ARO:3003600 name: OXA-444 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007729 ! OXA-60-like beta-lactamase synonym: "OXA-444" EXACT CARD_Short_Name [] [Term] id: ARO:3003601 name: OXA-445 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003602 name: OXA-446 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-446" EXACT CARD_Short_Name [] [Term] id: ARO:3003603 name: OXA-447 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-447" EXACT CARD_Short_Name [] [Term] id: ARO:3003604 name: OXA-448 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-448" EXACT CARD_Short_Name [] [Term] id: ARO:3003605 name: OXA-449 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-449" EXACT CARD_Short_Name [] [Term] id: ARO:3003606 name: OXA-450 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-450" EXACT CARD_Short_Name [] [Term] id: ARO:3003607 name: OXA-451 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-451" EXACT CARD_Short_Name [] [Term] id: ARO:3003608 name: OXA-452 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-452" EXACT CARD_Short_Name [] [Term] id: ARO:3003609 name: OXA-453 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-453" EXACT CARD_Short_Name [] [Term] id: ARO:3003610 name: OXA-454 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-454" EXACT CARD_Short_Name [] [Term] id: ARO:3003611 name: OXA-455 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007716 ! OXA-364-like beta-lactamase synonym: "OXA-455" EXACT CARD_Short_Name [] [Term] id: ARO:3003612 name: OXA-456 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003613 name: OXA-457 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-457" EXACT CARD_Short_Name [] [Term] id: ARO:3003614 name: OXA-458 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-458" EXACT CARD_Short_Name [] [Term] id: ARO:3003615 name: OXA-459 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-459" EXACT CARD_Short_Name [] [Term] id: ARO:3003616 name: OXA-460 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-460" EXACT CARD_Short_Name [] [Term] id: ARO:3003617 name: OXA-461 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-461" EXACT CARD_Short_Name [] [Term] id: ARO:3003618 name: OXA-462 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003619 name: OXA-463 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003620 name: OXA-464 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-464" EXACT CARD_Short_Name [] [Term] id: ARO:3003621 name: OXA-465 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-465" EXACT CARD_Short_Name [] [Term] id: ARO:3003622 name: OXA-466 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-466" EXACT CARD_Short_Name [] [Term] id: ARO:3003623 name: OXA-467 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003624 name: OXA-468 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003625 name: OXA-469 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003626 name: OXA-470 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-470" EXACT CARD_Short_Name [] [Term] id: ARO:3003627 name: OXA-471 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-471" EXACT CARD_Short_Name [] [Term] id: ARO:3003628 name: OXA-472 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-472" EXACT CARD_Short_Name [] [Term] id: ARO:3003629 name: OXA-473 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-473" EXACT CARD_Short_Name [] [Term] id: ARO:3003631 name: OXA-474 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-474" EXACT CARD_Short_Name [] [Term] id: ARO:3003632 name: OXA-475 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-475" EXACT CARD_Short_Name [] [Term] id: ARO:3003633 name: OXA-476 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-476" EXACT CARD_Short_Name [] [Term] id: ARO:3003634 name: OXA-477 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-477" EXACT CARD_Short_Name [] [Term] id: ARO:3003635 name: OXA-478 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-478" EXACT CARD_Short_Name [] [Term] id: ARO:3003636 name: OXA-479 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007732 ! OXA-63-like beta-lactamase synonym: "OXA-479" EXACT CARD_Short_Name [] [Term] id: ARO:3003637 name: OXA-480 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-480" EXACT CARD_Short_Name [] [Term] id: ARO:3003638 name: OXA-481 namespace: antibiotic_resistance def: "OXA-481 is a carbapenem-hydrolyzing class D beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-481" EXACT CARD_Short_Name [] [Term] id: ARO:3003639 name: OXA-482 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-482" EXACT CARD_Short_Name [] [Term] id: ARO:3003640 name: OXA-483 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-483" EXACT CARD_Short_Name [] [Term] id: ARO:3003641 name: OXA-484 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-484" EXACT CARD_Short_Name [] [Term] id: ARO:3003642 name: OXA-485 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-485" EXACT CARD_Short_Name [] [Term] id: ARO:3003643 name: OXA-486 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-486" EXACT CARD_Short_Name [] [Term] id: ARO:3003644 name: OXA-487 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3000017 ! OXA beta-lactamase [Term] id: ARO:3003645 name: OXA-488 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamases, no accessions or other information available." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-488" EXACT CARD_Short_Name [] [Term] id: ARO:3003646 name: CTX-M-162 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamase, no other information available." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-162" EXACT CARD_Short_Name [] [Term] id: ARO:3003647 name: CTX-M-163 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamase, no other information available." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-163" EXACT CARD_Short_Name [] [Term] id: ARO:3003648 name: CTX-M-164 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamase, no other information available." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-164" EXACT CARD_Short_Name [] [Term] id: ARO:3003649 name: CTX-M-165 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamase, no other information available." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-165" EXACT CARD_Short_Name [] [Term] id: ARO:3003650 name: CTX-M-166 namespace: antibiotic_resistance def: "Assigned by Lahey's list of beta-lactamase, no other information available." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-166" EXACT CARD_Short_Name [] [Term] id: ARO:3003652 name: CMY-132 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamases, no additional information available." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-132" EXACT CARD_Short_Name [] [Term] id: ARO:3003653 name: CMY-133 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamases, no additional information available." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-133" EXACT CARD_Short_Name [] [Term] id: ARO:3003654 name: CMY-134 namespace: antibiotic_resistance def: "CMY-134 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-134" EXACT CARD_Short_Name [] [Term] id: ARO:3003655 name: ACT-38 namespace: antibiotic_resistance def: "A class C beta-lactamase from Citrobacter freundii." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-38" EXACT CARD_Short_Name [] [Term] id: ARO:3003657 name: IMP-49 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamases, no additional information available." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-49" EXACT CARD_Short_Name [] [Term] id: ARO:3003658 name: IMP-50 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamases, no additional information available." [] is_a: ARO:3000020 ! IMP beta-lactamase [Term] id: ARO:3003659 name: IMP-51 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamases, no additional information available." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-51" EXACT CARD_Short_Name [] [Term] id: ARO:3003660 name: VIM-44 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamases, no additional information available." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-44" EXACT CARD_Short_Name [] [Term] id: ARO:3003661 name: VIM-45 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamases, no additional information available." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-45" EXACT CARD_Short_Name [] [Term] id: ARO:3003662 name: VIM-46 namespace: antibiotic_resistance def: "From Lahey's list of beta-lactamases, no additional information available." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-46" EXACT CARD_Short_Name [] [Term] id: ARO:3003663 name: NDM-15 namespace: antibiotic_resistance def: "New Delhi metallo-beta-lactamase-15 variant of NDM-1." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-15" EXACT CARD_Short_Name [] [Term] id: ARO:3003664 name: NDM-16a namespace: antibiotic_resistance def: "New Delhi class B metallo-beta-lactamase-16a variant of NDM-1." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-16" EXACT [] synonym: "NDM-16a" EXACT CARD_Short_Name [] [Term] id: ARO:3003665 name: NmcR namespace: antibiotic_resistance def: "NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase." [PMID:8052644] is_a: ARO:3000100 ! gene modulating beta-lactam resistance relationship: regulates ARO:3003589 ! NmcA synonym: "NmcR" EXACT CARD_Short_Name [] [Term] id: ARO:3003666 name: 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of bacteria can confer resistance to aminoglycosides." [] is_a: ARO:3003211 ! 16S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3003667 name: 16s rRNA with mutation conferring resistance to peptide antibiotics namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of bacteria can confer resistance to peptide antibiotics." [] is_a: ARO:3003211 ! 16S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003668 name: 16s rRNA with mutation conferring resistance to polyamine antibiotics namespace: antibiotic_resistance def: "Point mutations in the 16S rRNA of bacteria can confer resistance to polyamine antibiotics." [] is_a: ARO:3003211 ! 16S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic [Term] id: ARO:3003669 name: 16S rRNA with mutation conferring resistance to tetracycline derivatives namespace: antibiotic_resistance def: "Point mutations in the bacterial 16S rRNA region shown clinically to confer resistance to tetracycline and tetracycline derivatives (polyketide antibiotics)." [] is_a: ARO:3003211 ! 16S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:3000050 ! tetracycline antibiotic [Term] id: ARO:3003670 name: PEDO-1 namespace: antibiotic_resistance def: "PEDO-1 is a subclass B3 metallo-beta lactamase isolated from Pedobacter roseus exhibiting resistance to carbapenems." [PMID:26482314] is_a: ARO:3004220 ! subclass B3 PEDO beta-lactamase synonym: "PEDO-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003675 name: plazomicin namespace: antibiotic_resistance def: "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa." [PMID:21131322] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "ACHN-490" EXACT [] xref: pubchem.compound:42613186 [Term] id: ARO:3003676 name: AAC(6')-Ib' namespace: antibiotic_resistance def: "AAC(6')-Ib' is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in P. aeruginosa and P. fluorescens." [PMID:8138142, PMID:10720551] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib'" EXACT CARD_Short_Name [] [Term] id: ARO:3003677 name: AAC(6')-Iaj namespace: antibiotic_resistance def: "AAC(6')-Iaj is a functional acetyltransferase that modifies the amino groups at the 6' positions of aminoglycosides and contributes to aminoglycoside resistance of P. aeruginosa." [PMID:23070167] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iaj" EXACT CARD_Short_Name [] [Term] id: ARO:3003678 name: TriABC-OpmH namespace: antibiotic_resistance def: "TriABC-OpmH is a triclosan-specific efflux pump expressed in the Gram-negative Pseudomonas aeruginosa. TriABC is the only P. aeruginosa resistance nodulation cell division (RND) pump which contains two membrane fusion proteins, TriA and TriB, and both are required for efflux pump function. TriABC associated with OpmH assemble a functional triclosan efflux pump." [PMID:17720796] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan synonym: "TriABC-OpmH" EXACT CARD_Short_Name [] [Term] id: ARO:3003679 name: TriA namespace: antibiotic_resistance def: "TriA is a membrane protein that is fused to TriB and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa." [PMID:17720796] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003678 ! TriABC-OpmH synonym: "TriA" EXACT CARD_Short_Name [] [Term] id: ARO:3003680 name: TriB namespace: antibiotic_resistance def: "TriB is a membrane protein that is fused to TriA and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa." [PMID:17720796] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003678 ! TriABC-OpmH synonym: "TriB" EXACT CARD_Short_Name [] [Term] id: ARO:3003681 name: TriC namespace: antibiotic_resistance def: "TriC is a resistance nodulation cell division (RND) transporter that is a part of TriABC-OpmH, a triclosan-specific efflux protein." [PMID:17720796] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003678 ! TriABC-OpmH synonym: "TriC" EXACT CARD_Short_Name [] [Term] id: ARO:3003682 name: OpmH namespace: antibiotic_resistance def: "OpmH is an outer membrane efflux protein required for triclosan-specific efflux pump function." [PMID:15855547, PMID:17720796] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003678 ! TriABC-OpmH relationship: part_of ARO:3003691 ! MexJK-OpmH synonym: "OpmH" EXACT CARD_Short_Name [] [Term] id: ARO:3003684 name: Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation of Pseudomonas aeruginosa gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance." [PMID:8540700, PMID:22821356] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin relationship: confers_resistance_to_antibiotic ARO:3003690 ! sitafloxacin synonym: "Paer_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003685 name: Pseudomonas aeruginosa parE conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Pseudomonas aeruginosa parE resulting in sensitivity to fluoroquinolones (ciprofloxacin). In combination with a gyrase mutation (gyrA or gyrB), it confers a high level of resistance to ciprofloxacin." [PMID:23274661] is_a: ARO:3003313 ! fluoroquinolone resistant parE relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Paer_parE_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003686 name: Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem namespace: antibiotic_resistance def: "oprD is an outer membrane porin which facilitates the uptake of basic amino acids and imipenem in Pseudomonas aeruginosa." [PMID:23045355, PMID:25297323, PMID:12534469] is_a: ARO:3004278 ! Outer Membrane Porin (Opr) relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem synonym: "Paer_oprD_IPM" EXACT CARD_Short_Name [] [Term] id: ARO:3003688 name: PvrR namespace: antibiotic_resistance def: "PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence." [PMID:11961556] is_a: ARO:3004286 ! phenotypic variant regulator relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000043 ! carbenicillin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "PvrR" EXACT CARD_Short_Name [] [Term] id: ARO:3003689 name: MCR-1.1 namespace: antibiotic_resistance def: "MCR-1 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane." [PMID:26603172] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1" EXACT [] synonym: "MCR-1.1" EXACT CARD_Short_Name [] [Term] id: ARO:3003690 name: sitafloxacin namespace: antibiotic_resistance def: "Sitafloxacin is a fluoroquinolone active against multi-resistant Gram-positive and negative pathogens. Sitafloxacin shows inhibitory activity against DNA gyrase and topoisomerase IV, which blocks bacterial DNA replication, thereby causing double-stranded breaks in the bacterial chromosome." [PMID:21504249] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Gracevit" EXACT [] xref: pubchem.compound:461399 [Term] id: ARO:3003691 name: MexJK-OpmH namespace: antibiotic_resistance def: "MexJK-OpmH is a triclosan efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OpmH is the outer membrane efflux protein. MexJK is constitutively expressed in mexL mutants." [PMID:15855547, PMID:12193619] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan synonym: "MexJK-OpmH" EXACT CARD_Short_Name [] [Term] id: ARO:3003692 name: MexJ namespace: antibiotic_resistance def: "MexJ is the membrane fusion protein of the MexJK multidrug efflux protein." [PMID:12193619] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003691 ! MexJK-OpmH relationship: part_of ARO:3003694 ! MexJK-OprM synonym: "MexJ" EXACT CARD_Short_Name [] [Term] id: ARO:3003693 name: MexK namespace: antibiotic_resistance def: "MexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein." [PMID:12193619] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003691 ! MexJK-OpmH relationship: part_of ARO:3003694 ! MexJK-OprM synonym: "MexK" EXACT CARD_Short_Name [] [Term] id: ARO:3003694 name: MexJK-OprM namespace: antibiotic_resistance def: "MexJK-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OprM is the outer membrane factor protein." [PMID:15855547] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "MexJK-OprM" EXACT CARD_Short_Name [] [Term] id: ARO:3003697 name: MexPQ-OpmE namespace: antibiotic_resistance def: "MexPQ-OpmE multidrug efflux pump expressed in Pseudomonas aeruginosa. MexP is the membrane fusion protein; MexQ is the inner membrane transporter; and OpmE is the outer membrane channel." [PMID:16301811] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol relationship: confers_resistance_to_antibiotic ARO:3001227 ! kitasamycin relationship: confers_resistance_to_antibiotic ARO:3003701 ! rokitamycin synonym: "MexPQ-OpmE" EXACT CARD_Short_Name [] [Term] id: ARO:3003698 name: mexP namespace: antibiotic_resistance def: "MexP is the membrane fusion protein of the MexPQ-OpmE multidrug efflux complex." [PMID:16301811] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003697 ! MexPQ-OpmE synonym: "mexP" EXACT CARD_Short_Name [] [Term] id: ARO:3003699 name: mexQ namespace: antibiotic_resistance def: "MexQ is the inner membrane transporter of the multidrug efflux pump MexPQ-OpmE." [PMID:16301811] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003697 ! MexPQ-OpmE synonym: "mexQ" EXACT CARD_Short_Name [] [Term] id: ARO:3003700 name: opmE namespace: antibiotic_resistance def: "opmE is an outer membrane factor protein that is part of the multidrug efflux pump MexPQ-OpmE." [PMID:16301811] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003697 ! MexPQ-OpmE synonym: "opmE" EXACT CARD_Short_Name [] [Term] id: ARO:3003701 name: rokitamycin namespace: antibiotic_resistance def: "Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis." [PMID:1779258] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5282211 [Term] id: ARO:3003702 name: Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Pseudomonas aeruginosa parC resulting in fluoroquinolone resistance also requiring a gyrA mutation." [PMID:22821356, PMID:11451683] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Paer_ParC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003703 name: MexMN-OprM namespace: antibiotic_resistance def: "MexMN-OprM is a multidrug efflux pump expressed in Pseudomonas aeruginosa. MexM is the membrane fusion protein; MexN is the inner membrane transporter; and OprM is the outer membrane channel." [PMID:19713238] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "MexMN-OprM" EXACT CARD_Short_Name [] [Term] id: ARO:3003704 name: mexM namespace: antibiotic_resistance def: "mexM is the membrane fusion protein of the MexMN-OprM multidrug efflux complex." [PMID:19713238] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003703 ! MexMN-OprM synonym: "mexM" EXACT CARD_Short_Name [] [Term] id: ARO:3003705 name: mexN namespace: antibiotic_resistance def: "MexN is the inner membrane transporter of the MexMN-OprM multidrug efflux complex." [PMID:19713238] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003703 ! MexMN-OprM synonym: "mexN" EXACT CARD_Short_Name [] [Term] id: ARO:3003706 name: penem namespace: antibiotic_resistance def: "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur." [PMID:14620395, PMID:3043117] is_a: ARO:3000007 ! beta-lactam antibiotic [Term] id: ARO:3003707 name: faropenem namespace: antibiotic_resistance def: "Faropenem is an orally active beta-lactam antibiotic belonging to the penem group." [PMID:12615878] is_a: ARO:3003706 ! penem xref: pubchem.compound:65894 [Term] id: ARO:3003708 name: panipenem namespace: antibiotic_resistance def: "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial. It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity." [PMID:12678575] is_a: ARO:0000020 ! carbapenem xref: pubchem.compound:72015 [Term] id: ARO:3003709 name: MexZ namespace: antibiotic_resistance def: "MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa." [PMID:15336398] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3003032 ! MexXY-OprM relationship: regulates ARO:3003038 ! MexXY-OprA synonym: "MexZ" EXACT CARD_Short_Name [] [Term] id: ARO:3003710 name: MexL namespace: antibiotic_resistance def: "MexL is a specific repressor of mexJK transcription and autoregulates its own expression." [PMID:15855505] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3003691 ! MexJK-OpmH relationship: regulates ARO:3003694 ! MexJK-OprM synonym: "MexL" EXACT CARD_Short_Name [] [Term] id: ARO:3003712 name: VEB-1b namespace: antibiotic_resistance def: "VEB-1b is a beta-lactamase that is found in Pseudomonas aeruginosa." [PMID:11384532] is_a: ARO:3002370 ! VEB-1 synonym: "VEB-1b" EXACT CARD_Short_Name [] [Term] id: ARO:3003713 name: VCC-1 namespace: antibiotic_resistance def: "VCC-1 is a Class A carbapenemase isolated from Vibrio cholerae and exhibits resistance to penicillins, carbapenems and monobactam antibiotics." [PMID:26824956] is_a: ARO:3004196 ! VCC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000640 ! doripenem synonym: "VCC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003714 name: PEDO-2 namespace: antibiotic_resistance def: "PEDO-2 is a subclass B3 metallo-beta lactamase isolated from Pedobacter borealis exhibiting carbapenem resistance." [PMID:26482314] is_a: ARO:3004220 ! subclass B3 PEDO beta-lactamase synonym: "PEDO-2" EXACT CARD_Short_Name [] [Term] id: ARO:3003715 name: PEDO-3 namespace: antibiotic_resistance def: "PEDO-3 is a class B1 metallo-beta lactamase isolated from Pedobacter kyungheensis exhibiting resistance to carbapenems." [PMID:26482314] is_a: ARO:3004227 ! subclass B1 PEDO beta-lactamase synonym: "PEDO-3" EXACT CARD_Short_Name [] [Term] id: ARO:3003716 name: CPS-1 namespace: antibiotic_resistance def: "CPS-1 is a subclass B3 metallo-beta lactamase isolated from Chyseobacterium piscium exhibiting carbapenem resistance." [PMID:26666948] is_a: ARO:3004221 ! CPS beta-lactamase synonym: "B3CSP-1" EXACT [] synonym: "CPS-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003717 name: ESP-1 namespace: antibiotic_resistance def: "ESP-1 is a subclass B3 metallo-beta lactamase isolated from Epilithonimonas tenax conferring resistance to carbapenems." [PMID:26482314] is_a: ARO:3004222 ! ESP beta-lactamase synonym: "ESP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003718 name: MSI-1 namespace: antibiotic_resistance def: "MSI-1 is a subclass B3 metallo-beta lactamase isolated from Massilia oculi conferring resistance to carbapenems." [PMID:26482314] is_a: ARO:3004223 ! MSI beta-lactamase synonym: "MSI-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003719 name: MSI-OXA namespace: antibiotic_resistance def: "MSI-OXA is an OXA-85-like class D beta lactamase isolated from Massilia oculi." [PMID:26482314] is_a: ARO:3004242 ! MSI-OXA family beta-lactamase synonym: "MSI-OXA" EXACT CARD_Short_Name [] [Term] id: ARO:3003720 name: SPG-1 namespace: antibiotic_resistance def: "SPG-1 is a subclass B3 metallo-beta lactamase isolated from Sphingomonas sp." [PMID:26482314] is_a: ARO:3004224 ! SPG beta-lactamase synonym: "SPG-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003722 name: glycopeptide resistance gene cluster VanI namespace: antibiotic_resistance def: "This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX." [PMID:16513756, PMID:25042042, PMID:19414574] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_antibiotic ARO:0000029 ! teicoplanin synonym: "vanI_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3003723 name: vanI namespace: antibiotic_resistance def: "VanI is a D-Ala-D-Lac ligase that reduces vancomycin binding affinity, helping to confer vancomycin resistance as part of the VanI resistance gene cluster in Desulfitobacterium spp. and Desulfosporosinus spp." [PMID:19414574, PMID:25042042] is_a: ARO:3002978 ! D-Ala-D-Lac ligase relationship: part_of ARO:3003722 ! glycopeptide resistance gene cluster VanI synonym: "vanI" EXACT CARD_Short_Name [] [Term] id: ARO:3003724 name: vanW gene in vanI cluster namespace: antibiotic_resistance def: "Also known as vanWI, is a vanW variant found in the vanI gene cluster." [PMID:19414574, PMID:16513756] is_a: ARO:3000002 ! vanW relationship: part_of ARO:3003722 ! glycopeptide resistance gene cluster VanI synonym: "vanW-I" EXACT [] synonym: "vanWI" EXACT [] synonym: "vanW_in_vanI_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3003725 name: vanX gene in vanI cluster namespace: antibiotic_resistance def: "Also known as vanXI, is a vanX variant found in the vanI glycopeptide resistance gene cluster. It is a D-Ala-D-Ala dipeptidase." [PMID:25042042] is_a: ARO:3000011 ! vanX relationship: part_of ARO:3003722 ! glycopeptide resistance gene cluster VanI synonym: "vanX-I" EXACT [] synonym: "vanXI" EXACT [] synonym: "vanX_in_vanI_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3003726 name: vanS gene in vanI cluster namespace: antibiotic_resistance def: "Also known as vanSI, is a vanS variant found in the vanI gene cluster; it is a histidine kinase." [PMID:16513756, PMID:19414574] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3003722 ! glycopeptide resistance gene cluster VanI synonym: "vanS-I" EXACT [] synonym: "vanSI" EXACT [] synonym: "vanS_in_vanI_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3003727 name: vanK gene in vanI cluster namespace: antibiotic_resistance def: "Also known as vanKI, is a peptidoglycan bridge formation protein also known as FemAB that is part of the vanI glycopeptide resistance gene cluster." [PMID:25042042, PMID:19414574] is_a: ARO:3002915 ! vanK relationship: part_of ARO:3003722 ! glycopeptide resistance gene cluster VanI synonym: "vanK-I" EXACT [] synonym: "vanKI" EXACT [] synonym: "vanK_in_vanI_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3003728 name: vanR gene in vanI cluster namespace: antibiotic_resistance def: "Also known as vanRI, is the regulatory transcriptional activator in the vanSR regulator within the vanI glycopeptide resistance gene cluster." [PMID:19414574, PMID:25042042] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3003722 ! glycopeptide resistance gene cluster VanI synonym: "vanR-I" EXACT [] synonym: "vanRI" EXACT [] synonym: "vanR_in_vanI_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3003731 name: fusD namespace: antibiotic_resistance def: "A specific fusidic acid resistance gene conferring intrinsic resistance in the bacteria Staphylococcus saprophyticus. FusD behaves by causing dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. It is considered a FusB-type protein." [PMID:17325218] is_a: ARO:3005086 ! Target protecting FusB-type protein conferring resistance to Fusidic acid relationship: confers_resistance_to_antibiotic ARO:3000759 ! fusidic acid synonym: "fusD" EXACT CARD_Short_Name [] [Term] id: ARO:3003733 name: fusC namespace: antibiotic_resistance def: "FusC is a fusidic acid resistance gene enabling ribosomal translocase EF-G dissociation from the ribosome that has been detected in Staphylococcus aureus and Staphylococcus intermedius. Its mechanism is believed to be similar to fusB due to its high level of sequence homology. It is considered a FusB-type protein." [PMID:17325218] is_a: ARO:3005086 ! Target protecting FusB-type protein conferring resistance to Fusidic acid relationship: confers_resistance_to_antibiotic ARO:3000759 ! fusidic acid synonym: "fusC" EXACT CARD_Short_Name [] [Term] id: ARO:3003734 name: antibiotic resistant fusA namespace: antibiotic_resistance def: "Antibiotic resistant fusA is caused by mutations to the elongation factor G (EF-G) and confers resistance to fusidic acid." [PMID:19289529] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007153 ! fusidane antibiotic [Term] id: ARO:3003735 name: Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid namespace: antibiotic_resistance def: "The mutations to this gene are involved in altering the translation elongation factor G (EF-G) in association with the ribosome to prevent fusidic acid from binding EF-G and preventing translation." [PMID:33353175, PMID:20430787, PMID:12519196, PMID:11309125, PMID:19289529, PMID:20566766] is_a: ARO:3003734 ! antibiotic resistant fusA relationship: confers_resistance_to_antibiotic ARO:3000759 ! fusidic acid synonym: "Saur_fusA_FA" EXACT CARD_Short_Name [] [Term] id: ARO:3003736 name: antibiotic resistant fusE namespace: antibiotic_resistance def: "Antibiotic resistant fusE is caused by mutations in a region of the rplF gene encoding riboprotein L6, and confers resistance to fusidic acid." [PMID:19289529] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007153 ! fusidane antibiotic [Term] id: ARO:3003737 name: Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid namespace: antibiotic_resistance def: "The mutations to the rplF gene encoding riboprotein L6 have been shown to cause fusidic acid resistance, demonstrating a potential secondary site of action of the antibiotic that is blocked through these mutations. Several types of mutations have been identified that cause resistance, including SNPs, frameshift mutations and early stop codons." [PMID:20729356, PMID:19289529, PMID:17923494, PMID:20430787] is_a: ARO:3003736 ! antibiotic resistant fusE relationship: confers_resistance_to_antibiotic ARO:3000759 ! fusidic acid synonym: "50S ribosomal subunit protein L6" EXACT [] synonym: "Saur_fusE_FA" EXACT CARD_Short_Name [] synonym: "rplF" EXACT [] [Term] id: ARO:3003741 name: mphE namespace: antibiotic_resistance def: "mphE is a macrolide phosphotransferase and resistance gene identified on a plasmid, pRSB105." [PMID:29317655, PMID:17261525] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "mphE" EXACT CARD_Short_Name [] [Term] id: ARO:3003742 name: mphG namespace: antibiotic_resistance def: "The mphG gene encodes a macrolide 2'-phosphotransferase found in Photobacterium damselae sharing sequence similarity to mphA in E. coli." [PMID:29317655, PMID:25765542] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "mphG" EXACT CARD_Short_Name [] [Term] id: ARO:3003744 name: vatF namespace: antibiotic_resistance def: "vatF is a streptogramin A acetyl transferase gene isolated from the chromosome of Yersinia enterocolitica." [PMID:10722489] is_a: ARO:3000453 ! streptogramin vat acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "vatF" EXACT CARD_Short_Name [] [Term] id: ARO:3003762 name: lnuE namespace: antibiotic_resistance def: "lnuE encodes a lincosamide resistance gene isolated from Streptococcus suis that was truncated by an ISEnfa5-cfr-ISEnfa5 segment insertion. It shares the closest sequence similarity to lnuA." [PMID:24366733] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin synonym: "linE" EXACT [] synonym: "lnuE" EXACT CARD_Short_Name [] [Term] id: ARO:3003745 name: mef(C) namespace: antibiotic_resistance def: "mef(C) is a macrolide efflux gene isolated from a plasmid in Photobacterium damselae." [PMID:22446310] is_a: ARO:3000747 ! mef relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "mef(C)" EXACT CARD_Short_Name [] synonym: "mefC" EXACT [] [Term] id: ARO:3003746 name: optrA namespace: antibiotic_resistance def: "OptrA is a member of the ABC-F protein subfamily that confers resistance to oxazolidinones. The gene encoding the protein was originally isolated from a plasmid in Enterococcus faecalis and Enterococcus faecium." [PMID:25977397] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol relationship: confers_resistance_to_antibiotic ARO:3003897 ! tedizolid synonym: "optrA" EXACT CARD_Short_Name [] [Term] id: ARO:3003748 name: oleC namespace: antibiotic_resistance def: "oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion." [PMID:8326867] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000867 ! oleandomycin synonym: "oleC" EXACT CARD_Short_Name [] [Term] id: ARO:3003749 name: salA namespace: antibiotic_resistance def: "salA is an ABC-F subfamily protein gene isolated from the chromosome of Mammaliicoccus sciuri conferring resistance to lincosamides and streptogramins." [PMID:24687494, PMID:25891423] is_a: ARO:3007030 ! sal-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin synonym: "sal(A)" EXACT [] synonym: "salA" EXACT CARD_Short_Name [] [Term] id: ARO:3003751 name: Escherichia coli nfsA mutations conferring resistance to nitrofurantoin namespace: antibiotic_resistance def: "nfsA encodes the major oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA." [PMID:15684426, PMID:18544599, PMID:26552976] is_a: ARO:3003754 ! antibiotic resistant nfsA relationship: confers_resistance_to_antibiotic ARO:0000075 ! nitrofurantoin synonym: "Ecol_nfsA_NIT" EXACT CARD_Short_Name [] [Term] id: ARO:3003761 name: eatAv namespace: antibiotic_resistance def: "eatAv is a mutated form of the wildtype eatA ABC-F subfamily protein isolated from Enterococcus faecium conferring resistance to lincosamides, streptogramin A's and pleuromutilins (LSaP phenotype)." [PMID:22366422, PMID:23836170] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:3001317 ! pleuromutilin synonym: "eatAv" EXACT CARD_Short_Name [] [Term] id: ARO:3003754 name: antibiotic resistant nfsA namespace: antibiotic_resistance def: "The nfsA-encoded nitroreductase is the major oxygen-insensitive nitroreductase present in E. coli. NfsA uses only NADPH and has broad electron acceptor specificity. Mutations in nfsA cause resistance to nitrofurazone and furazolidone. Resistance to nitrofurantoin via mutation of nfsA reduces the fitness of clinical isolates of E. coli." [PMID:15684426, PMID:18544599, PMID:9791100, PMID:338576] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3004116 ! nitrofuran antibiotic [Term] id: ARO:3003755 name: Antibiotic resistant nfsB namespace: antibiotic_resistance def: "The nsfB gene encodes a minor oxygen-insensitive nitroreductase. NfsB reduces a broad range of nitroaromatic compounds including the antibiotics nitrofurazone and nitrofurantoin. NfsB is a flavin mononucleotide (FMN)-containing protein and uses both NADH and NADPH as a source of reducing equivalents. Mutations in nfsB lead to increased resistance to nitrofurazone and furazolidone in an nfsA mutant background." [PMID:9791100, PMID:7011517, PMID:338576, PMID:8947835] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3004116 ! nitrofuran antibiotic [Term] id: ARO:3003756 name: Escherichia coli nfsB with mutation conferring resistance to nitrofurantoin namespace: antibiotic_resistance def: "nfsB encodes the minor oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA, while the increased resistance associated with second step mutants is a consequence of nfsB mutation." [PMID:26552976, PMID:18544599, PMID:9791100] is_a: ARO:3003755 ! Antibiotic resistant nfsB relationship: confers_resistance_to_antibiotic ARO:0000075 ! nitrofurantoin synonym: "Ecol_nfsB_NIT" EXACT CARD_Short_Name [] [Term] id: ARO:3003760 name: Enterococcus faecalis cls with mutation conferring resistance to daptomycin namespace: antibiotic_resistance def: "Cardiolipin synthase (cls) is an inner membrane protein involved in membrane synthesis and phosopholipid metabolism, with mutations to the gene being capable of conferring daptomycin resistance." [PMID:23114777, PMID:23959318, PMID:24957825] is_a: ARO:3003272 ! daptomycin resistant cls relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: derives_from ARO:3003275 ! Daptomycin sensitive cardiolipin synthetase synonym: "Efae_cls_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003729 name: Staphylococcus aureus ileS with mutation conferring resistance to mupirocin namespace: antibiotic_resistance def: "Point mutations to the isoleucyl-tRNA synthetase (ileS) in Staphylococcus aureus that confer resistance to mupirocin." [PMID:11796355] is_a: ARO:3000446 ! antibiotic-resistant isoleucyl-tRNA synthetase (ileS) relationship: confers_resistance_to_antibiotic ARO:3000554 ! mupirocin synonym: "Saur_ileS_MUP" EXACT CARD_Short_Name [] [Term] id: ARO:3003730 name: Bifidobacterium bifidum ileS conferring resistance to mupirocin namespace: antibiotic_resistance def: "Bifidobacteria have an intrinsically resistant form of ileS (isoleucyl-tRNA synthetase) that confers resistance to mupirocin." [PMID:21421794] is_a: ARO:3000446 ! antibiotic-resistant isoleucyl-tRNA synthetase (ileS) relationship: confers_resistance_to_antibiotic ARO:3000554 ! mupirocin synonym: "Bbif_ileS_MUP" EXACT CARD_Short_Name [] [Term] id: ARO:3003764 name: resistance by absence namespace: antibiotic_resistance def: "Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin)." [] is_a: ARO:1000002 ! mechanism of antibiotic resistance [Term] id: ARO:3003767 name: mphM namespace: antibiotic_resistance def: "mphM is a chromosomally-encoded macrolide phosphotransferases that inactivate 14-, 15- and 16-membered macrolides." [PMID:29317655, PMID:25059531] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "mphM" EXACT CARD_Short_Name [] [Term] id: ARO:3003768 name: gene conferring resistance via absence namespace: antibiotic_resistance def: "Deletion of gene or gene product results in resistance. For example, deletion of a porin gene blocks drug from entering the cell." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:3003764 ! resistance by absence [Term] id: ARO:3003769 name: Staphylococcus aureus mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. A point mutation in the putative mprF synthase domain is associated with enhanced expression, increased synthesis and reduced daptomycin surface binding. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins." [PMID:14769468, PMID:20498310, PMID:19915718] is_a: ARO:3000863 ! defensin resistant mprF relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "Saur_mprF" EXACT CARD_Short_Name [] [Term] id: ARO:3003770 name: Listeria monocytogenes mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins." [PMID:19915718, PMID:17042784] is_a: ARO:3000863 ! defensin resistant mprF relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "Lmon_mprF" EXACT CARD_Short_Name [] [Term] id: ARO:3003772 name: Brucella suis mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins." [PMID:19915718] is_a: ARO:3000863 ! defensin resistant mprF relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "Bsui_mprF" EXACT CARD_Short_Name [] [Term] id: ARO:3003773 name: Clostridium perfringens mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins." [PMID:19915718] is_a: ARO:3000863 ! defensin resistant mprF relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "Cper_mprF" EXACT CARD_Short_Name [] [Term] id: ARO:3003774 name: Streptococcus agalactiae mprF namespace: antibiotic_resistance def: "MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins." [PMID:19915718] is_a: ARO:3000863 ! defensin resistant mprF relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "Saga_mprF" EXACT CARD_Short_Name [] [Term] id: ARO:3003775 name: Escherichia coli murA with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species." [PMID:8281938, PMID:20071153, PMID:8664284, PMID:23143172] is_a: ARO:3002811 ! antibiotic-resistant murA transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Ecol_murA_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003776 name: Staphylococcus aureus murA with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance." [PMID:26793179] is_a: ARO:3002811 ! antibiotic-resistant murA transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Saur_murA_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003777 name: Borreliella burgdorferi murA with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Mutations to the murA enzyme confers resistance to the antibiotic." [PMID:21294548] is_a: ARO:3002811 ! antibiotic-resistant murA transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Bbur_mur_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003778 name: Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations in the Mycolicibacterium smegmatis ndh gene that results in increased resistance to isoniazid." [PMID:15673755] is_a: ARO:3003460 ! antibiotic resistant ndh relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Msme_ndh_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3003779 name: Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations in the Mycobacterium tuberculosis variant bovis ndh gene that results in increased resistance to isoniazid." [PMID:15673755] is_a: ARO:3003460 ! antibiotic resistant ndh relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mbov_ndh_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3003780 name: nybomycin namespace: antibiotic_resistance def: "A heterocyclic antibiotic that targets mutant gyrA (type II topoisomerase) containing an S84L substitution, counteracting acquired quinolone resistance. It is effective against quinolone-resistant Gram-positive bacteria including S. aureus and E. faecalis. Due to its ability to counteract quinolone resistance by targeting the mutant form of the gyrA protein, it is classified as a reverse antibiotic (RA)." [PMID:22534508, PMID:16589716] is_a: ARO:3007157 ! nybomycin-like antibiotic xref: pubchem.compound:169159 [Term] id: ARO:3003784 name: Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin namespace: antibiotic_resistance def: "Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance." [PMID:10589726, PMID:22404577] is_a: ARO:3002811 ! antibiotic-resistant murA transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Mtub_murA_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003785 name: Chlamydia trachomatis intrinsic murA conferring resistance to fosfomycin namespace: antibiotic_resistance def: "Chlamydia murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 119 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance." [PMID:12562791] is_a: ARO:3002811 ! antibiotic-resistant murA transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Ctra_murA_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003786 name: fluoroquinolone self resistant parC namespace: antibiotic_resistance def: "Inherent parC resistance to fluoroquinolone from an antibiotic producer. The presence of these genes confers self-resistance to the antibiotic it produces." [] is_a: ARO:3000492 ! gene involved in self-resistance to antibiotic relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic [Term] id: ARO:3003787 name: aminocoumarin self resistant parY namespace: antibiotic_resistance def: "Inherent ParY resistant to aminocoumarin from an antibiotic producer. The presence of these genes confers self resistance to the antibiotic it produces." [] is_a: ARO:3000492 ! gene involved in self-resistance to antibiotic relationship: confers_resistance_to_drug_class ARO:3000103 ! aminocoumarin antibiotic [Term] id: ARO:3003788 name: Bacillus subtilis pgsA with mutation conferring resistance to daptomycin namespace: antibiotic_resistance def: "Point mutations that occur within the Bacillus subtilis pgsA gene resulting in resistance to daptomycin." [PMID:21709092, PMID:12044378] is_a: ARO:3003080 ! daptomycin resistant pgsA relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Bsub_pgsA_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003789 name: Campylobacter jejuni gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Campylobacter jejuni is a major bacterial infectious agent associated with gastroenteritis. Quinolone resistance is reportedly conferred by a single C-257-T nucleotide substitution in the gyrA gene." [PMID:26658311] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Cjej_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003790 name: Enterococcus faecium liaF mutant conferring daptomycin resistance namespace: antibiotic_resistance def: "liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance." [PMID:21899450, PMID:15793168] is_a: ARO:3003279 ! antibiotic resistant liaFSR system is_a: ARO:3004262 ! daptomycin resistant liaF relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efac_liaF_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003791 name: Enterococcus faecalis liaS mutant conferring daptomycin resistance namespace: antibiotic_resistance def: "liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance." [PMID:21899450] is_a: ARO:3003279 ! antibiotic resistant liaFSR system is_a: ARO:3004264 ! daptomycin resistant liaS relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efae_liaS_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003792 name: Enterococcus faecalis liaR mutant conferring daptomycin resistance namespace: antibiotic_resistance def: "liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance." [PMID:23959318] is_a: ARO:3003279 ! antibiotic resistant liaFSR system is_a: ARO:3004263 ! daptomycin resistant liaR relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efae_liaR_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003793 name: SPM-1 namespace: antibiotic_resistance def: "Plasmid-mediated SPM metallo-beta-lactamase conferring resistance to carbapenem. Originally isolated from Pseudomonas aeruginosa. Responsible for carbapenem-resistant Pseudomonas aeruginosa (CRPA) outbreaks in Brazil." [PMID:12407123, PMID:16239284] is_a: ARO:3000580 ! SPM beta-lactamase synonym: "SPM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003794 name: Staphylococcus aureus walK with mutation conferring resistance to daptomycin namespace: antibiotic_resistance def: "walK is the histidine kinase sensor of a two-component regulatory system controlling peptidoglycan metabolism through regulation of the expression of most of the peptidoglycan hydrolase genes. Mutations in the gene have been found that confer daptomycin resistance." [PMID:16723576, PMID:23554895] is_a: ARO:3003795 ! daptomycin resistant walK relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Saur_walK_DAP" EXACT CARD_Short_Name [] synonym: "vicK" EXACT [] synonym: "yycG" EXACT [] [Term] id: ARO:3003795 name: daptomycin resistant walK namespace: antibiotic_resistance def: "Mutations to the walK gene, part of a cell wall metabolism 2-component regulatory system, confers resistance to antibiotics, specifically daptomycin." [PMID:23554895] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003796 name: Acinetobacter baumannii ampC beta-lactamase namespace: antibiotic_resistance def: "A class C beta-lactamase found in Acinetobacter baumannii that confers resistance to piperacillin and cefepime." [PMID:21304033] is_a: ARO:3004232 ! ampC-type beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin synonym: "Abau_ampC_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3003797 name: Enterococcus faecalis YybT with mutation conferring daptomycin resistance namespace: antibiotic_resistance def: "YybT has phosphodiesterase activity towards cyclic dinucleotides using a c-di-GMP hydrolyzing phosphodiesterase domain. Mutations to the gene confer resistance to daptomycin." [PMID:19901023, PMID:23959318] is_a: ARO:3003798 ! daptomycin resistant YybT relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efae_YybT_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003798 name: daptomycin resistant YybT namespace: antibiotic_resistance def: "Mutations to the YybT gene confers daptomycin resistance." [PMID:19901023, PMID:23959318] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003800 name: Enterococcus faecalis gdpD with mutation conferring daptomycin resistance namespace: antibiotic_resistance def: "gdpD is a glycerolphosphodiesterase whose mutations confer resistance to daptomycin." [PMID:23959318] is_a: ARO:3003802 ! daptomycin resistant gdpD relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efae_gdpD_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003801 name: bcr-1 namespace: antibiotic_resistance def: "Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene." [PMID:26093374, PMID:25085655] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000055 ! bicyclomycin synonym: "bcr-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003802 name: daptomycin resistant gdpD namespace: antibiotic_resistance def: "Mutations to the gdpD glycerolphosphodiesterase confer resistance to daptomycin." [PMID:23959318] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003803 name: Staphylococcus aureus agrA with mutation conferring resistance to daptomycin namespace: antibiotic_resistance def: "agrA is an autoinducer in a peptide-quorum two-component regulatory system whose mutations confer daptomycin resistance." [PMID:22685286, PMID:23554895] is_a: ARO:3003804 ! daptomycin resistant agrA relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Saur_agrA_DAP" EXACT CARD_Short_Name [] synonym: "accessory gene regulator protein A" EXACT [] [Term] id: ARO:3003804 name: daptomycin resistant agrA namespace: antibiotic_resistance def: "Mutations to the regulatory gene agrA confer daptomycin resistance." [PMID:22685286, PMID:23554895] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003805 name: Enterococcus faecalis gshF with mutation conferring daptomycin resistance namespace: antibiotic_resistance def: "gshF is a bifunctional glutamate-cysteine ligase/ glutathione synthetase that when mutated, confers daptomycin resistance." [PMID:23959318] is_a: ARO:3003806 ! daptomycin resistant gshF relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efae_gshF_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003806 name: daptomycin resistant gshF namespace: antibiotic_resistance def: "Mutations to the glutathione synthetase gshF confers daptomycin resistance." [PMID:23959318] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003807 name: Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime namespace: antibiotic_resistance def: "AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli." [PMID:16189130] is_a: ARO:3000702 ! acrR relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "Ecol_AcrR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3003808 name: carO namespace: antibiotic_resistance def: "carO is a transmembrane beta-barrel involved in the influx of carbapenem antibiotics in Acinetobacter baumannii. Disruption of the carO gene by distinct insertion elements results in a loss of carO expression causing resistance to carbapenem antibiotics. Homologs of carO have been identified in genera Acinetobacter, Moraxella and Psychrobacter." [PMID:15793123] is_a: ARO:3003768 ! gene conferring resistance via absence is_a: ARO:3004283 ! CarO porin relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem synonym: "carO" EXACT CARD_Short_Name [] [Term] id: ARO:3003809 name: Acinetobacter baumannii OprD conferring resistance to imipenem namespace: antibiotic_resistance def: "An outer member protein (OMP) found in Acinetobacter baumannii involved in the uptake of imipenem and basic amino acids. This porin is homologous to Pseudomonas aeruginosa OprD, which performs an identical function." [PMID:16335991] is_a: ARO:3003768 ! gene conferring resistance via absence is_a: ARO:3004278 ! Outer Membrane Porin (Opr) relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem synonym: "Abau_OprD_IPM" EXACT CARD_Short_Name [] [Term] id: ARO:3003810 name: kirromycin self resistant EF-Tu namespace: antibiotic_resistance def: "Natural producers of kirromycin and kirromycin-like antibiotics (i.e., kirrothrycin) possess self-resistance, which is classified here." [PMID:9043138] is_a: ARO:3000492 ! gene involved in self-resistance to antibiotic relationship: confers_resistance_to_drug_class ARO:3001219 ! elfamycin antibiotic [Term] id: ARO:3003811 name: adeC namespace: antibiotic_resistance def: "AdeC is the outer membrane factor of the AdeABC multidrug efflux complex. It can be replaced by other outer membrane channels, and is not essential for antibiotic resistance." [PMID:21173183] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000770 ! AdeABC synonym: "adeC" EXACT CARD_Short_Name [] [Term] id: ARO:3003813 name: Enterococcus faecalis drmA with mutation conferring daptomycin resistance namespace: antibiotic_resistance def: "drmA is an uncharacterized 6-pass membrane protein, with mutations to the protein causing modest resistance to daptomycin." [PMID:23959318] is_a: ARO:3003814 ! daptomycin resistant drmA relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efae_drmA_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003814 name: daptomycin resistant drmA namespace: antibiotic_resistance def: "Mutations to drmA confer daptomycin resistance." [PMID:23959318] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003815 name: Enterococcus faecalis YvlB with mutation conferring daptomycin resistance namespace: antibiotic_resistance def: "YvlB is a putative target of the liaFSR signalling pathway, whose mutations confer daptomycin resistance." [PMID:23959318] is_a: ARO:3003816 ! daptomycin resistant YvlB relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Efae_YvlB_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3003816 name: daptomycin resistant YvlB namespace: antibiotic_resistance def: "Mutations to the putative liaFSR target YvlB confer daptomycin resistance." [PMID:23959318] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003817 name: Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Mutations in the A subunit of DNA gyrase reduce its affinity for fluoroquinolones, thereby conferring resistance." [PMID:15282231, PMID:21304033] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Abau_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003818 name: Acinetobacter baumannii parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Mutations in Acinetobacter baumannii parC that result in resistance to fluoroquinolones." [PMID:36010006, PMID:27175500] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000660 ! lomefloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000664 ! trovafloxacin relationship: confers_resistance_to_antibiotic ARO:3000665 ! grepafloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3000762 ! pefloxacin synonym: "Abau_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003820 name: mgrB namespace: antibiotic_resistance def: "mgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae." [PMID:25190723] is_a: ARO:3007684 ! transmembrane protein conferring colistin resistance relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "YobG" EXACT [] synonym: "mgrB" EXACT CARD_Short_Name [] [Term] id: ARO:3003821 name: BAL30072 namespace: antibiotic_resistance def: "BAL30072 is a monocyclic beta-lactam antibiotic belonging to the sulfactams. BAL30072 was found to trigger the spheroplasting and lysis of Escherichia coli rather than the formation of extensive filaments." [PMID:23449829, PMID:20308379] is_a: ARO:0000004 ! monobactam xref: pubchem.compound:52942440 [Term] id: ARO:3003822 name: battacin namespace: antibiotic_resistance def: "Battacin is a cationic lipopeptide antibiotic produced from a Paenibacillus tianmuensis soil isolate. Battacin kills bacteria in vitro and has potent activity against Gram-negative bacteria, including multidrug-resistant and extremely drug-resistant clinical isolates. The bactericidal kinetics of battacin correlate with the depolarization of the cell membrane, suggesting that battacin kills bacteria by disrupting the cytoplasmic membrane." [PMID:22183171] is_a: ARO:3000035 ! lipopeptide antibiotic synonym: "octapeptin B5" EXACT [] [Term] id: ARO:3003823 name: benzalkonium chloride namespace: antibiotic_resistance def: "Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent." [PMID:9079913] is_a: ARO:3005386 ! disinfecting agents and antiseptics synonym: "8001-54-5" EXACT [] synonym: "Benzalkonium" EXACT [] synonym: "D00857" EXACT [] synonym: "Zephiran chloride" EXACT [] xref: pubchem.compound:2330 [Term] id: ARO:3003830 name: Aminocoumarin resistant alaS namespace: antibiotic_resistance def: "An alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli." [PMID:10217798] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_drug_class ARO:3000103 ! aminocoumarin antibiotic [Term] id: ARO:3003831 name: temocillin namespace: antibiotic_resistance def: "Temocillin is a beta-lactamase resistant carboxypenicillin. It is primarily used for the treatment of multiple drug resistant, Gram-negative bacteria, specifically Enterobacteriaceae." [PMID:22115539, PMID:22294983] is_a: ARO:3000008 ! penam synonym: "BRL 17421" EXACT [] synonym: "Temocilline" EXACT [] synonym: "Temocillinum" EXACT [] xref: pubchem.compound:171758 [Term] id: ARO:3003832 name: ticarcillin namespace: antibiotic_resistance def: "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death." [PMID:22252797, PMID:21504594] is_a: ARO:3003706 ! penem synonym: "Ticarcilina" EXACT [] synonym: "Ticarcilline" EXACT [] synonym: "Ticarcillinum" EXACT [] xref: pubchem.compound:36921 [Term] id: ARO:3003835 name: cdeA namespace: antibiotic_resistance def: "Clostridioides difficile and Escherichia coli multidrug efflux transporter with antiporter function. Confers resistance to fluoroquinolones in E. coli and acriflavin in Clostridioides difficile." [PMID:15383161] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "cdeA" EXACT CARD_Short_Name [] [Term] id: ARO:3003836 name: qacH namespace: antibiotic_resistance def: "qacH is a subunit of the qac multidrug efflux pump in Staphylococcus saprophyticus." [PMID:9631545] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics synonym: "qacH" EXACT CARD_Short_Name [] [Term] id: ARO:3003838 name: gadW namespace: antibiotic_resistance def: "GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and, in situations where GadX is missing, activates gadA and gadBC." [PMID:12446650, PMID:16980449] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000788 ! MdtEF-TolC synonym: "YhiW" EXACT [] synonym: "gadW" EXACT CARD_Short_Name [] [Term] id: ARO:3003839 name: Mrx namespace: antibiotic_resistance def: "Mrx is part of the macrolide inactivation gene cluster in Aeromonas hydrophila." [PMID:16339607] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Mrx" EXACT CARD_Short_Name [] [Term] id: ARO:3003840 name: aminocoumarin resistant cysB namespace: antibiotic_resistance def: "Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin, an aminocoumarin antibiotic, in Escherichia coli." [PMID:1886615] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_drug_class ARO:3000103 ! aminocoumarin antibiotic [Term] id: ARO:3003841 name: kdpE namespace: antibiotic_resistance def: "kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding." [PMID:12618449, PMID:23555240] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004046 ! kdpDE synonym: "kdpE" EXACT CARD_Short_Name [] [Term] id: ARO:3003842 name: MUS-2 namespace: antibiotic_resistance def: "MUS-2 is a chromosome-encoded beta-lactamase from Myroides odoratimimus." [PMID:26257915] is_a: ARO:3004067 ! MUS beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "MUS-2" EXACT CARD_Short_Name [] [Term] id: ARO:3003843 name: leuO namespace: antibiotic_resistance def: "leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump." [PMID:21883529, PMID:19429622] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3004101 ! MdtNOP synonym: "leuO" EXACT CARD_Short_Name [] [Term] id: ARO:3003844 name: mfd namespace: antibiotic_resistance def: "mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor, is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions." [PMID:18535657, PMID:17239578] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "mfd" EXACT CARD_Short_Name [] [Term] id: ARO:3003846 name: ADC beta-lactamase without carbapenemase activity namespace: antibiotic_resistance def: "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis." [PMID:15980372] is_a: ARO:3005459 ! ADC beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3003847 name: ADC-1 namespace: antibiotic_resistance def: "ADC-1 is a beta-lactamase found in Acinetobacter baumannii." [PMID:10639377] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3003848 name: ADC-2 namespace: antibiotic_resistance def: "ADC-2 is a beta-lactamase found in Oligella urethralis." [PMID:12709319] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-2" EXACT CARD_Short_Name [] [Term] id: ARO:3003849 name: ADC-3 namespace: antibiotic_resistance def: "ADC-3 is a beta-lactamase found in Acinetobacter baumannii." [PMID:12709319] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-3" EXACT CARD_Short_Name [] [Term] id: ARO:3003850 name: ADC-4 namespace: antibiotic_resistance def: "ADC-4 is a beta-lactamase found in Acinetobacter baumannii." [PMID:12709319] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-4" EXACT CARD_Short_Name [] [Term] id: ARO:3003851 name: ADC-5 namespace: antibiotic_resistance def: "ADC-5 is a beta-lactamase found in Acinetobacter pittii." [PMID:15047547] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-5" EXACT CARD_Short_Name [] [Term] id: ARO:3003852 name: ADC-6 namespace: antibiotic_resistance def: "ADC-6 is a beta-lactamase found in Acinetobacter baumannii." [PMID:14742218] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-6" EXACT CARD_Short_Name [] [Term] id: ARO:3003853 name: ADC-7 namespace: antibiotic_resistance def: "ADC-7 is a beta-lactamase that is found in Acinetobacter baumannii." [PMID:15980372] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-7" EXACT CARD_Short_Name [] [Term] id: ARO:3003854 name: ADC-8 namespace: antibiotic_resistance def: "ADC-8 is a beta-lactamase found in Acinetobacter sp." [PMID:17403709] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-8" EXACT CARD_Short_Name [] [Term] id: ARO:3003855 name: ADC-10 namespace: antibiotic_resistance def: "ADC-10 is a beta-lactamase found in Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-10" EXACT CARD_Short_Name [] [Term] id: ARO:3003856 name: ADC-12 namespace: antibiotic_resistance def: "ADC-12 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-12" EXACT CARD_Short_Name [] [Term] id: ARO:3003857 name: ADC-13 namespace: antibiotic_resistance def: "ADC-13 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-13" EXACT CARD_Short_Name [] [Term] id: ARO:3003858 name: ADC-14 namespace: antibiotic_resistance def: "ADC-14 is a beta-lactamase found in Acinetobacter pittii." [PMID:18065824, PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-14" EXACT CARD_Short_Name [] [Term] id: ARO:3003859 name: ADC-15 namespace: antibiotic_resistance def: "ADC-15 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-15" EXACT CARD_Short_Name [] [Term] id: ARO:3003860 name: ADC-16 namespace: antibiotic_resistance def: "ADC-16 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-16" EXACT CARD_Short_Name [] [Term] id: ARO:3003861 name: ADC-17 namespace: antibiotic_resistance def: "ADC-17 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-17" EXACT CARD_Short_Name [] [Term] id: ARO:3003862 name: ADC-18 namespace: antibiotic_resistance def: "ADC-18 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-18" EXACT CARD_Short_Name [] [Term] id: ARO:3003863 name: ADC-19 namespace: antibiotic_resistance def: "ADC-19 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-19" EXACT CARD_Short_Name [] [Term] id: ARO:3003864 name: ADC-20 namespace: antibiotic_resistance def: "ADC-20 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-20" EXACT CARD_Short_Name [] [Term] id: ARO:3003865 name: ADC-21 namespace: antibiotic_resistance def: "ADC-21 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-21" EXACT CARD_Short_Name [] [Term] id: ARO:3003866 name: ADC-22 namespace: antibiotic_resistance def: "ADC-22 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-22" EXACT CARD_Short_Name [] [Term] id: ARO:3003867 name: ADC-23 namespace: antibiotic_resistance def: "ADC-23 is a beta-lactamase found in Acinetobacter pittii." [PMID:19029333] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-23" EXACT CARD_Short_Name [] [Term] id: ARO:3003868 name: ADC-25 namespace: antibiotic_resistance def: "ADC-25 is a beta-lactamase found in Acinetobacter baumannii." [PMID:18077141] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-25" EXACT CARD_Short_Name [] [Term] id: ARO:3003870 name: ADC-31 namespace: antibiotic_resistance def: "ADC-31 is a beta-lactamase found in Acinetobacter baumannii." [PMID:22038960] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-31" EXACT CARD_Short_Name [] [Term] id: ARO:3003871 name: ADC-39 namespace: antibiotic_resistance def: "ADC-39 is a beta-lactamase found in Acinetobacter baumannii." [PMID:18765689] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-39" EXACT CARD_Short_Name [] [Term] id: ARO:3003872 name: ADC-41 namespace: antibiotic_resistance def: "ADC-41 is a beta-lactamase found in Acinetobacter pittii." [PMID:20368407] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-41" EXACT CARD_Short_Name [] [Term] id: ARO:3003873 name: ADC-42 namespace: antibiotic_resistance def: "ADC-42 is a beta-lactamase found in Acinetobacter pittii." [PMID:20368407] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-42" EXACT CARD_Short_Name [] [Term] id: ARO:3003874 name: ADC-43 namespace: antibiotic_resistance def: "ADC-43 is a beta-lactamase found in Acinetobacter pittii." [PMID:20368407] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-43" EXACT CARD_Short_Name [] [Term] id: ARO:3003875 name: Enterococcus faecium EF-Tu mutants conferring resistance to elfamycin namespace: antibiotic_resistance def: "Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to elfamycin antibiotics." [PMID:7989561] is_a: ARO:3001312 ! elfamycin resistant EF-Tu [Term] id: ARO:3003876 name: ADC-44 namespace: antibiotic_resistance def: "ADC-44 is a beta-lactamase found in Acinetobacter pittii." [PMID:20368407] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-44" EXACT CARD_Short_Name [] [Term] id: ARO:3003878 name: ADC-56 namespace: antibiotic_resistance def: "ADC-56 is a beta-lactamase found in Acinetobacter baumannii." [PMID:21788456] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-56" EXACT CARD_Short_Name [] [Term] id: ARO:3003879 name: ADC-61 namespace: antibiotic_resistance def: "ADC-61 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26125919] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-61" EXACT CARD_Short_Name [] [Term] id: ARO:3003880 name: ADC-74 namespace: antibiotic_resistance def: "ADC-74 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26824943] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-74" EXACT CARD_Short_Name [] [Term] id: ARO:3003881 name: ADC-75 namespace: antibiotic_resistance def: "ADC-75 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26824943] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-75" EXACT CARD_Short_Name [] [Term] id: ARO:3003882 name: ADC-76 namespace: antibiotic_resistance def: "ADC-76 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26824943] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-76" EXACT CARD_Short_Name [] [Term] id: ARO:3003883 name: ADC-77 namespace: antibiotic_resistance def: "ADC-77 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26824943] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-77" EXACT CARD_Short_Name [] [Term] id: ARO:3003884 name: ADC-78 namespace: antibiotic_resistance def: "ADC-78 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26824943] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-78" EXACT CARD_Short_Name [] [Term] id: ARO:3003885 name: ADC-79 namespace: antibiotic_resistance def: "ADC-79 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26824943] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-79" EXACT CARD_Short_Name [] [Term] id: ARO:3003886 name: ADC-80 namespace: antibiotic_resistance def: "ADC-80 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26824943] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-80" EXACT CARD_Short_Name [] [Term] id: ARO:3003887 name: ADC-81 namespace: antibiotic_resistance def: "ADC-81 is a beta-lactamase found in Acinetobacter baumannii." [PMID:26824943] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-81" EXACT CARD_Short_Name [] [Term] id: ARO:3003888 name: ADC-82 namespace: antibiotic_resistance def: "ADC-82 is a beta-lactamase found in Acinetobacter baumannii." [PMID:21398552, PMID:22952140] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-82" EXACT CARD_Short_Name [] [Term] id: ARO:3003889 name: Escherichia coli GlpT with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria." [PMID:20071153, PMID:12936984] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004247 ! antibiotic-resistant GlpT relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Ecol_GlpT_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003890 name: Escherichia coli UhpT with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria." [PMID:20071153] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004248 ! antibiotic-resistant UhpT relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Ecol_UhpT_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003893 name: Escherichia coli uhpA with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "uhpA is a positive activator of the fosfomycin importer uhpT, thus mutations to uhpA confer fosfomycin resistance by reducing uhpT expression. Both knockout and amino acid substitution mutations have been found that confer resistance, with the Protein Knockout model describing the large, knockout mutations causing loss of function of the gene, and the Protein Variant model describing the amino acid substitutions." [PMID:20071153] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004249 ! UhpA relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Ecol_uhpA_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003894 name: Rm3 namespace: antibiotic_resistance def: "Rm3 is a class B3 metallo-beta-lactamase isolated from a metagenomic soil sample in Yorkshire, United Kingdom, shown to confer resistance to clinically used penicillins, cephalosporins, and carbapenems." [PMID:27431213] is_a: ARO:3004225 ! Rm3 family beta-lactamase synonym: "Rm3" EXACT CARD_Short_Name [] [Term] id: ARO:3003895 name: Pseudomonas mutant PhoP conferring resistance to colistin namespace: antibiotic_resistance def: "Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin." [PMID:24412662] is_a: ARO:3000834 ! phoP relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "Paer_PhoP_CST" EXACT CARD_Short_Name [] [Term] id: ARO:3003896 name: Pseudomonas mutant PhoQ conferring resistance to colistin namespace: antibiotic_resistance def: "Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin." [PMID:24412662] is_a: ARO:3000835 ! phoQ relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "Paer_PhoQ_CST" EXACT CARD_Short_Name [] [Term] id: ARO:3003897 name: tedizolid namespace: antibiotic_resistance def: "Tedizolid is a synthetic oxazolidinone antibiotic that is administered to the patient as a prodrug that is activated in vivo. It acts as an inhibitor of protein synthesis by binding the 50S subunit of the ribosome and preventing formation of the 70S initiation complex. It is active against Gram-positive pathogens." [PMID:27904526, PMID:22324973] is_a: ARO:3000079 ! oxazolidinone antibiotic xref: pubchem.compound:11234049 [Term] id: ARO:3003898 name: lugdunin namespace: antibiotic_resistance def: "Lugdunin is a thiazolidine-containing cyclic peptide antibiotic isolated from nasal Staphylococcus lugnunensis that prohibits Staphylococcus aureus colony formation. It is a human commensal bacteria, indicating the potential for further antibiotic discoveries from human microbiota." [PMID:27466123] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:121596231 [Term] id: ARO:3003899 name: Escherichia coli PtsI with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "PtsI (phosphoenolpyruvate-protein phosphotransferase) is involved in cyclic AMP synthesis, which regulates glpT expression. As a result, mutations to ptsI confer resistance to fosfomycin by affecting the regulation of fosfomycin import." [PMID:20071153] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004250 ! antibiotic-resistant ptsI phosphotransferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Ecol_PtsI_FOF" EXACT CARD_Short_Name [] synonym: "phosphoenolpyruvate-protein phosphotransferase" EXACT [] [Term] id: ARO:3003900 name: Escherichia coli cyaA with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "CyaA (adenylate cyclase) is involved with the synthesis of cyclic AMP which regulates the fosfomycin transporter glpT. As a result, mutations to cyaA confer resistance to fosfomycin." [PMID:14519998, PMID:20071153] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004251 ! antibiotic-resistant cya adenylate cyclase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Ecol_cyaA_FOF" EXACT CARD_Short_Name [] synonym: "adenylate cyclase" EXACT [] [Term] id: ARO:3003901 name: Staphylococcus aureus GlpT with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "Mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria." [PMID:26793179] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004247 ! antibiotic-resistant GlpT relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Saur_GlpT_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003902 name: Staphylococcus aureus UhpT with mutation conferring resistance to fosfomycin namespace: antibiotic_resistance def: "Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria." [PMID:26793179] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004248 ! antibiotic-resistant UhpT relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Saur_UhpT_FOF" EXACT CARD_Short_Name [] [Term] id: ARO:3003903 name: thusin namespace: antibiotic_resistance def: "Thusin is a two-component lantibiotic isolated from B. thuringiensis strain BGSC 4BT1, exhibiting antimicrobial activity against several Gram-positive pathogens. Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus (MRSA), Mammaliicoccus sciuri, Enterococcus faecalis, and Streptococcus pneumoniae have all shown susceptibility to Thusin, with inhibition activities greater than Vancomycin or other lantibiotics." [PMID:27486447] is_a: ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003904 name: formicin namespace: antibiotic_resistance def: "Formicin is a two-component broad-spectrum lantibiotic produced by Bacillus paralicheniformis APC 1576, exhibiting antimicrobial activity against several Gram-positive species, including Staphylococcus aureus, Clostridioides difficile and Listeria monocytogenes." [PMID:27450592] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:69365 [Term] id: ARO:3003905 name: ANT(4')-Ib namespace: antibiotic_resistance def: "Aminoglycoside nucleotidyltransferase sequence from Staphylococcus aureus plasmid." [PMID:20585117, PMID:12654668] is_a: ARO:3007403 ! ANT(4')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000652 ! isepamicin synonym: "ANT(4')-Ib" EXACT CARD_Short_Name [] synonym: "aadD2" EXACT [] [Term] id: ARO:3003907 name: cipA namespace: antibiotic_resistance def: "Cfr-like methyltransferase enzyme conferring resistance to multiple clinically relevant antibiotic classes." [PMID:23752511] is_a: ARO:3004609 ! cfr(B) Group relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3000672 ! madumycin II relationship: confers_resistance_to_antibiotic ARO:3000673 ! griseoviridin relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin synonym: "cipA" EXACT CARD_Short_Name [] [Term] id: ARO:3003908 name: Erm(47) namespace: antibiotic_resistance def: "Chromosome-encoded gene conferring MLSB resistance. Identified from Helcococcus kunzii." [PMID:27494920] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin synonym: "Erm(47)" EXACT CARD_Short_Name [] [Term] id: ARO:3003915 name: Lysocin E namespace: antibiotic_resistance def: "A drug which binds to menaquinone in the bacterial cell membrane. Binding of Lysocin to menaquinone facilitates lysis of the cell." [PMID:25485686] is_a: ARO:3003919 ! lysocin xref: pubchem.compound:53373747 [Term] id: ARO:3003916 name: menaquinone namespace: antibiotic_resistance def: "A molecule involved in electron transport in bacterial cell membrane." [PMID:25485686] is_a: ARO:3000708 ! antibiotic target is_a: ARO:3000710 ! cell membrane component targeted by antibiotic relationship: targeted_by_antibiotic ARO:3003915 ! Lysocin E synonym: "Vitamin K2" EXACT [] xref: pubchem.compound:5287554 [Term] id: ARO:3003917 name: Staphylococcus aureus menA with mutation conferring resistance to lysocin namespace: antibiotic_resistance def: "menA encodes a 1,4-dihydroxy-2-naphthoate octaprenyltransferase, with mutations to the protein conferring resistance to lysocin E." [PMID:25485686] is_a: ARO:3004265 ! lysocin resistant menA relationship: confers_resistance_to_antibiotic ARO:3003915 ! Lysocin E synonym: "Saur_menA_LYS" EXACT CARD_Short_Name [] [Term] id: ARO:3003918 name: apmA namespace: antibiotic_resistance def: "Plasmid-borne apramycin-resistant aminocyclitol acetyltransferase gene identified from bovine MRSA." [PMID:20876371, PMID:33563840, PMID:37973888] is_a: ARO:3000341 ! AAC(2') relationship: confers_resistance_to_antibiotic ARO:0000037 ! apramycin synonym: "apmA" EXACT CARD_Short_Name [] [Term] id: ARO:3003919 name: lysocin namespace: antibiotic_resistance def: "Lysocin family of peptide antibiotics isolated from Lysobacter spp." [PMID:25485686] is_a: ARO:3000053 ! peptide antibiotic [Term] id: ARO:3003920 name: pgpB namespace: antibiotic_resistance def: "A gene that produces the protein lipid A 4'-phosphatase." [PMID:20657724] is_a: ARO:3004287 ! lipid A phosphatase relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B synonym: "PGN-0524" EXACT [] synonym: "pgpB" EXACT CARD_Short_Name [] [Term] id: ARO:3003921 name: oqxAB namespace: antibiotic_resistance def: "oqxAB encodes for OqxAB, a plasmid-encoded efflux pump, which confer resistance to multiple agents including fluoroquinolones." [PMID:19528276] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000075 ! nitrofurantoin relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "oqxAB" EXACT CARD_Short_Name [] [Term] id: ARO:3003922 name: oqxA namespace: antibiotic_resistance def: "RND efflux pump conferring resistance to fluoroquinolone." [PMID:19528276] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003921 ! oqxAB synonym: "oqxA" EXACT CARD_Short_Name [] [Term] id: ARO:3003923 name: oqxB namespace: antibiotic_resistance def: "RND efflux pump conferring resistance to fluoroquinolone." [PMID:19528276] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003921 ! oqxAB synonym: "oqxB" EXACT CARD_Short_Name [] [Term] id: ARO:3003924 name: Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation of Haemophilus parainfluenzae gyrA resulted in the lowered affinity between fluoroquinolones and GyrA. Thus, conferring resistance. Both Ser and Tyr are hydrophilic amino acids, however Tyr has an additional bulky hydrophobic group which could affect the interaction between the DNA gyrase with quinolones." [PMID:27497656] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Hpin_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003925 name: Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation of Haemophilus parainfluenzae parC resulted in the lowered affinity between fluoroquinolones and ParC. Thus, conferring resistance." [PMID:27497656] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Hpin_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003926 name: Salmonella enterica gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid, a fluoroquinolone antibiotic. These mutations have also been shown to reduce susceptibility to ciprofloxacin." [PMID:27559761, PMID:27630841] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid synonym: "Sent_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003927 name: ceftolozane namespace: antibiotic_resistance def: "A fifth generation cephalosporin antibiotic." [PMID:27522066] is_a: ARO:0000032 ! cephalosporin synonym: "Zerbaxa" EXACT [] xref: pubchem.compound:53234134 [Term] id: ARO:3003928 name: Neisseria gonorrhoeae gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Neisseria gonorrhoeae DNA gyrase subunit A. Decreases affinity between fluoroquinolone antibiotic molecule and gyrA, thereby conferring resistance to fluoroquinolone." [PMID:30961546, PMID:27506605] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Ngon_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003929 name: Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in Neisseria gonorrhoeae parC protein that confer resistance to fluoroquinolone by reducing affinity to antibiotic binding site." [PMID:27506605, PMID:30961546] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Ngon_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003930 name: rpsJ namespace: antibiotic_resistance def: "rpsJ is a tetracycline resistance protein identified in Neisseria gonorrhoeae. Tetracycline resistance is conferred by binding to the ribosome as a 30S ribosomal protection protein." [PMID:27506605] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "nusE" EXACT [] synonym: "rpsJ" EXACT CARD_Short_Name [] [Term] id: ARO:3003931 name: Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Capnocytophaga gingivalis that decreases binding affinity of fluoroquinolone antibiotics to gyrA, thereby conferring resistance." [PMID:27531625] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "Cgin_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003932 name: antibiotic efflux inhibitor namespace: antibiotic_resistance def: "Compounds and molecules that inhibit the action of antibiotic efflux proteins, thereby decreasing resistance caused by efflux pumps." [] is_a: ARO:3007224 ! adjuvants inhibiting antibiotic removal [Term] id: ARO:3003933 name: Berberine namespace: antibiotic_resistance def: "Berberine is a benzylisoquinoline alkaloid shown to reduce MexXY-dependent antibiotic resistance of cephalosporins, macrolides, lincosamides and aminoglycosides in Pseudomonas, Burkholderia and Achromobacter." [PMID:27547203] is_a: ARO:3003932 ! antibiotic efflux inhibitor xref: pubchem.compound:2353 [Term] id: ARO:3003936 name: Omadacycline namespace: antibiotic_resistance def: "An aminomethylcycline antibiotic that targets 16s rRNA in gram positive and gram negative bacteria." [PMID:27669321] is_a: ARO:3000050 ! tetracycline antibiotic xref: pubchem.compound:54697325 [Term] id: ARO:3003937 name: Neisseria meningititis PBP2 conferring resistance to beta-lactam namespace: antibiotic_resistance def: "Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2, thereby conferring resistance to beta-lactam." [PMID:16940068, PMID:27690121, PMID:26787702, PMID:18986991, PMID:25987627, PMID:25199775] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000646 ! cefixime synonym: "Nmen_PBP2_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3003938 name: Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics namespace: antibiotic_resistance def: "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3003040 ! beta-lactam resistant penicillin-binding proteins relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3003939 name: Salmonella enterica parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in Salmonella parC gene implicated in decreased susceptibility to fluoroquinolone antibiotics, primarily ciprofloxacin and nalidixic acid." [PMID:27630841] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid synonym: "Sent_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003940 name: Shigella flexneri gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in Shigella flexneri gyrA observed to confer resistance to fluoroquinolone antibiotics." [PMID:27620866] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "Sfle_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003941 name: Shigella flexneri parC conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in parC conferring resistance to fluoroquinolone antibiotics in Shigella flexneri,." [PMID:27620866] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "Sfle_parC_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003942 name: abcA namespace: antibiotic_resistance def: "AbcA is a multidrug resistant ABC transporter that confers resistance to methicillin, daptomycin, cefotaxime, and moenomycin." [PMID:24509312, PMID:26160745, PMID:19800843] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000015 ! methicillin relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3000697 ! moenomycin A1 synonym: "abcA" EXACT CARD_Short_Name [] [Term] id: ARO:3003947 name: EfrAB namespace: antibiotic_resistance def: "EfrAB is a heterodimeric ABC transporter efflux pump found in Enterococcus faecalis and Enterococcus faecium that confers resistance to ciprofloxacin, erythromycin, rifampicin, quinupristine." [PMID:14638474, PMID:25084670] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin [Term] id: ARO:3003948 name: efrA namespace: antibiotic_resistance def: "efrA is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer drug resistance." [PMID:14638474, PMID:25084670] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003947 ! EfrAB synonym: "efrA" EXACT CARD_Short_Name [] [Term] id: ARO:3003949 name: efrB namespace: antibiotic_resistance def: "efrB is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer multidrug resistance." [PMID:25084670, PMID:14638474] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003947 ! EfrAB synonym: "efrB" EXACT CARD_Short_Name [] [Term] id: ARO:3003950 name: msbA namespace: antibiotic_resistance def: "MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability." [PMID:19678712, PMID:12358070, PMID:27499013, PMID:12195740] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "msbA" EXACT CARD_Short_Name [] [Term] id: ARO:3003951 name: microcin J25 namespace: antibiotic_resistance def: "Microcin J25 is a peptide antibiotic that inhibits transcription by bacterial RNA polymerase. MccJ25 is produced by Escherichia coli strains that harbor a plasmid-borne antibiotic-synthesis and antibiotic-export cassette, consisting of a gene for MccJ25 precursor (a 58 residue linear peptide), two genes for factors that process MccJ25 precursor into MccJ25, and one gene for export of MccJ25." [PMID:15200952] is_a: ARO:3000053 ! peptide antibiotic synonym: "MccJ25" EXACT [] xref: pubchem.compound:10793809 [Term] id: ARO:3003952 name: YojI namespace: antibiotic_resistance def: "YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI." [PMID:15866933] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3003951 ! microcin J25 synonym: "YojI" EXACT CARD_Short_Name [] [Term] id: ARO:3003953 name: hmrM namespace: antibiotic_resistance def: "hmrM is a multidrug efflux pump belonging to the MATE family and functions as a Na+/drug antiporter." [PMID:14695443, PMID:16614254] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "hmrM" EXACT CARD_Short_Name [] [Term] id: ARO:3003954 name: efmA namespace: antibiotic_resistance def: "efmA is an MFS transporter permease in E. faecium." [PMID:19252300] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "efmA" EXACT CARD_Short_Name [] [Term] id: ARO:3003955 name: efpA namespace: antibiotic_resistance def: "efpA is an MFS transporter found in Mycobacterium tuberculosis." [PMID:9008277, PMID:15215089, PMID:21871582] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "efpA" EXACT CARD_Short_Name [] [Term] id: ARO:3003956 name: antibacterial free fatty acids namespace: antibiotic_resistance def: "Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to kill or inhibit the growth of bacteria. The antibacterial properties of FFAs are used by many organisms to defend against parasitic or pathogenic bacteria. The prime target of FFA action is the cell membrane, where FFAs disrupt the electron transport chain and oxidative phosphorylation. Besides interfering with cellular energy production, FFA action may also result from the inhibition of enzyme activity, impairment of nutrient uptake, generation of peroxidation and auto-oxidation degradation products or direct lysis of bacterial cells." [PMID:19956944] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3003957 name: palmitic acid namespace: antibiotic_resistance def: "Palmitic acid is the most common saturated fatty acid found in animals, plants, and microorganisms. Palmitic acid is found to have antibacterial properties." [PMID:11744302, PMID:19956944, PMID:10447892] is_a: ARO:3003956 ! antibacterial free fatty acids synonym: "Cetylic acid" EXACT [] synonym: "Hexadecanoic acid" EXACT [] synonym: "N-Hexadecanoic acid" EXACT [] synonym: "Palmitate" EXACT [] xref: pubchem.compound:985 [Term] id: ARO:3003958 name: oleic acid namespace: antibiotic_resistance def: "Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. Oleic acid is found to have antibacterial activity, particularly in inhibiting the growth of several Gram-positive bacterial species." [PMID:18754790, PMID:19956944, PMID:10447892, PMID:10925024, PMID:393631] is_a: ARO:3003956 ! antibacterial free fatty acids synonym: "Cis-9-Octadecenoic acid" EXACT [] synonym: "Cis-Oleic acid" EXACT [] synonym: "Elaidoic acid" EXACT [] synonym: "Oleate" EXACT [] xref: pubchem.compound:445639 [Term] id: ARO:3003959 name: linoleic acid namespace: antibiotic_resistance def: "Linoleic acid is a polyunsaturated omega-6 fatty acid. Linoleic acid has been found to have antibacterial activity, particularly in inhibiting the growth of Gram-positive bacterial species." [PMID:93615, PMID:19956944, PMID:10447892, PMID:10925024] is_a: ARO:3003956 ! antibacterial free fatty acids synonym: "Linoleate" EXACT [] synonym: "Linolic acid" EXACT [] synonym: "Telfairic acid" EXACT [] xref: pubchem.compound:5280450 [Term] id: ARO:3003960 name: farAB namespace: antibiotic_resistance def: "farAB is an MFS efflux pump found in gonococci that is involved in antibacterial fatty acid resistance. Moreover, expression of the tandemly linked farA and farB genes was positively associated with the presence of the MtrR transcriptional regulatory protein that normally downregulates the expression of mtrCDE." [PMID:10447892] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3003957 ! palmitic acid relationship: confers_resistance_to_antibiotic ARO:3003958 ! oleic acid relationship: confers_resistance_to_antibiotic ARO:3003959 ! linoleic acid [Term] id: ARO:3003961 name: farA namespace: antibiotic_resistance def: "farA is the membrane fusion protein that is part of the farAB efflux pump." [PMID:10447892] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003960 ! farAB synonym: "farA" EXACT CARD_Short_Name [] [Term] id: ARO:3003962 name: farB namespace: antibiotic_resistance def: "farB is the cytoplasmic transporter protein that is part of the farAB efflux pump. farB corresponds to 3 loci in Pseudomonas aeruginosa PAO1 and 3 loci in Pseudomonas aeruginosa LESB58." [PMID:10447892] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3003960 ! farAB synonym: "farB" EXACT CARD_Short_Name [] [Term] id: ARO:3003963 name: flo namespace: antibiotic_resistance def: "The Flo transporters can be plasmid- or chromosome-encoded. flo is an important determinant of florfenicol resistance in animal isolates of E. coli but is also found in human pathogens (e.g. Salmonella enterica and V. cholerae)." [PMID:15914491, PMID:11101601, PMID:10639375] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol [Term] id: ARO:3003964 name: hp1181 namespace: antibiotic_resistance def: "hp1181 is a translocase that is part of the MFS efflux pump family. It is found in H. pylori and has role in the active efflux of antibiotics." [PMID:27303615] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "hp1181" EXACT CARD_Short_Name [] [Term] id: ARO:3003965 name: hp1184 namespace: antibiotic_resistance def: "hp1184 is a translocase that belongs to the MATE efflux pump family. It is found in H. pylori and is involved in the active efflux of antibiotics." [PMID:15793129, PMID:27303615] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "hp1184" EXACT CARD_Short_Name [] [Term] id: ARO:3003966 name: Klebsiella pneumoniae OmpK35 namespace: antibiotic_resistance def: "Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK35 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism." [PMID:27645385] is_a: ARO:3003768 ! gene conferring resistance via absence is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3003999 ! cefamandole synonym: "Kpne_OmpK35" EXACT CARD_Short_Name [] [Term] id: ARO:3003967 name: lfrA namespace: antibiotic_resistance def: "lfrA is involved in the active efflux of quinolones and is found in Mycobacteroides abscessus." [PMID:8682782] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "lfrA" EXACT CARD_Short_Name [] [Term] id: ARO:3003968 name: Klebsiella pneumoniae OmpK36 namespace: antibiotic_resistance def: "Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism." [PMID:27645385] is_a: ARO:3003768 ! gene conferring resistance via absence is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "Kpne_OmpK36" EXACT CARD_Short_Name [] [Term] id: ARO:3003969 name: lmrP namespace: antibiotic_resistance def: "lmrP is a proton motive force-dependent drug transporter that is part of the MFS efflux pump family." [PMID:11577166, PMID:7592810, PMID:10532389] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000667 ! demeclocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline relationship: confers_resistance_to_antibiotic ARO:3000674 ! dalfopristin relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic relationship: confers_resistance_to_drug_class ARO:3000050 ! tetracycline antibiotic synonym: "lmrP" EXACT CARD_Short_Name [] [Term] id: ARO:3003970 name: D-Ala-D-Ala ligase namespace: antibiotic_resistance def: "Non-van ligases that synthesize D-Ala-D-Ala, the default cell wall precursor that makes a cell vulnerable to glycopeptide antibiotics. Mutations in the ddl gene can cause the production of nonfunctional/inactivated D-Ala-D-Ala ligases, which can render bacteria glycopeptide dependent depending on the presence of vancomycin resistance clusters." [PMID:11274474, PMID:16323116] is_a: ARO:3002906 ! Van ligase relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "Ddl" EXACT CARD_Short_Name [] [Term] id: ARO:3003971 name: Erm(44)v namespace: antibiotic_resistance def: "Variant of Erm(44)v isolated from Staphylococcus saprophyticus, confers resistance to lincosamide and macrolide antibiotics but not streptogramins." [PMID:27799208] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "Erm(44)v" EXACT CARD_Short_Name [] [Term] id: ARO:3003972 name: Solithromycin namespace: antibiotic_resistance def: "A clinically developed Macrolide antibiotic targeting gram positive and gram negative bacteria." [PMID:27909995] is_a: ARO:0000000 ! macrolide antibiotic synonym: "CEM-101" EXACT [] xref: pubchem.compound:72734351 [Term] id: ARO:3003974 name: Cutibacterium acnes gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in Cutibacterium acnes gyrA protein known to confer resistance to fluoroquinolone antibiotics." [PMID:27793740] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin synonym: "Cacn_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003975 name: pactamycin namespace: antibiotic_resistance def: "Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor." [PMID:9398510] is_a: ARO:3007158 ! pactamycin-like antibiotic xref: pubchem.compound:5289124 [Term] id: ARO:3003976 name: 16S rRNA with mutation conferring resistance to pactamycin namespace: antibiotic_resistance def: "Point mutations in bacterial 16S rRNA that confer resistance to antibiotic pactamycin." [PMID:9398510] is_a: ARO:3003211 ! 16S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:3007158 ! pactamycin-like antibiotic [Term] id: ARO:3003977 name: Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin namespace: antibiotic_resistance def: "Point mutations in Halobacterium 16S rRNA that confer resistance to pactamycin antibiotic." [PMID:9398510] is_a: ARO:3003976 ! 16S rRNA with mutation conferring resistance to pactamycin relationship: confers_resistance_to_antibiotic ARO:3003975 ! pactamycin synonym: "Hsal_16S_PAC" EXACT CARD_Short_Name [] [Term] id: ARO:3003978 name: Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin namespace: antibiotic_resistance def: "Point mutation in C. reinhardtii rrnS conferring resistance to streptomycin antibiotic." [PMID:2583478] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Crei_16rrnS_STR" EXACT CARD_Short_Name [] [Term] id: ARO:3003979 name: Eravacycline namespace: antibiotic_resistance def: "A fluorocycline that acts to inhibit the bacterial ribosome." [PMID:23979750] is_a: ARO:3000050 ! tetracycline antibiotic synonym: "7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline" EXACT [] synonym: "TP-434" EXACT [] xref: pubchem.compound:54726192 [Term] id: ARO:3003980 name: tetA(58) namespace: antibiotic_resistance def: "TetA(58) is a Tetracycline efflux pump described in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tetA(58)" EXACT CARD_Short_Name [] [Term] id: ARO:3003981 name: tetB(58) namespace: antibiotic_resistance def: "Tetracycline resistant TetB(58) efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tetB(58)" EXACT CARD_Short_Name [] [Term] id: ARO:3003982 name: LlmA 23S ribosomal RNA methyltransferase namespace: antibiotic_resistance def: "Lincosamide (Clindamycin) resistant (putative) ribosomal methyltransferase related to the RlmK 23S rRNA methyltransferase COG family. Detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus found in Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3004273 ! Llm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "LlmA_23S_CLI" EXACT CARD_Short_Name [] [Term] id: ARO:3003983 name: CatU namespace: antibiotic_resistance def: "Chloramphenicol acetyltransferase conferring resistance to phenicol antibiotics detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000382 ! azidamfenicol relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol synonym: "CatU" EXACT CARD_Short_Name [] [Term] id: ARO:3003984 name: BahA namespace: antibiotic_resistance def: "Bacitracin amidohydrolase found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance by bacitracin inactivation through amidohydrolysis. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3004260 ! Bah amidohydrolase relationship: confers_resistance_to_antibiotic ARO:0000041 ! bacitracin relationship: participates_in ARO:3003985 ! amidohydrolysis of bacitracin undecaprenyl pyrophosphate synonym: "BahA" EXACT CARD_Short_Name [] [Term] id: ARO:3003985 name: amidohydrolysis of bacitracin undecaprenyl pyrophosphate namespace: antibiotic_resistance def: "Hydrolysis of amido side-chain of asparagine-12 forming hydrogen bond with undecaprenyl pyrophosphate in bacitracin leading to antibiotic inactivation." [] is_a: ARO:3000040 ! hydrolysis of antibiotic conferring resistance [Term] id: ARO:3003986 name: TaeA namespace: antibiotic_resistance def: "Pleuromutilin (Tiamulin) ABC efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to pleuromutilin antibiotics. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3001317 ! pleuromutilin synonym: "TaeA" EXACT CARD_Short_Name [] [Term] id: ARO:3003987 name: VatI namespace: antibiotic_resistance def: "Streptogramin A acetyltransferase found in Paenibacillus sp. LC231, isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin A antibiotics. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3000453 ! streptogramin vat acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 synonym: "VatI" EXACT CARD_Short_Name [] [Term] id: ARO:3003988 name: AAC(2')-IIb namespace: antibiotic_resistance def: "AAC(2')-IIb is an intrinsic Kasugamycin 2' acetyltransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics, including kasugamycin. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3007394 ! AAC(2')-II relationship: confers_resistance_to_antibiotic ARO:3001296 ! kasugamycin synonym: "AAC(2')-IIb" EXACT CARD_Short_Name [] [Term] id: ARO:3003989 name: AAC(6')-34 namespace: antibiotic_resistance def: "AAC(6')-34 is an aminoglycoside 6'-phosphotransferase found in Paenibacillus sp. LC231, a strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "AAC(6')-34" EXACT CARD_Short_Name [] [Term] id: ARO:3003990 name: vgbC namespace: antibiotic_resistance def: "VgbC is a streptogramin B-type lyase found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin B-type antibiotics by linearization of the lactone ring on an ester bond, resulting in antibiotic inactivation. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3000376 ! streptogramin vgb lyase relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000584 ! quinupristin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3000678 ! pristinamycin IC relationship: confers_resistance_to_antibiotic ARO:3000679 ! vernamycin C relationship: confers_resistance_to_antibiotic ARO:3000680 ! patricin A relationship: confers_resistance_to_antibiotic ARO:3000681 ! patricin B relationship: confers_resistance_to_antibiotic ARO:3000682 ! ostreogrycin B3 synonym: "vgbC" EXACT CARD_Short_Name [] [Term] id: ARO:3003991 name: mphI namespace: antibiotic_resistance def: "mphI is a macrolide phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to macrolide antibiotics. Described by Pawlowski et al. 2016." [PMID:29317655, PMID:27929110] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin synonym: "mphI" EXACT CARD_Short_Name [] [Term] id: ARO:3003992 name: rphB namespace: antibiotic_resistance def: "rphB is a rifampin phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to rifamycin antibiotics, specifically rifampin, through rifampin inactivation. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3004040 ! rifampin phosphotransferase relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "rphB" EXACT CARD_Short_Name [] [Term] id: ARO:3003993 name: capreomycin namespace: antibiotic_resistance def: "Capreomycin is an aminoglycoside antibiotic, capable of treating a large number of infections but in particular used for killing bacteria causing tuberculosis." [PMID:73540] is_a: ARO:0000016 ! aminoglycoside antibiotic xref: pubchem.compound:122130878 [Term] id: ARO:3003994 name: cpaA namespace: antibiotic_resistance def: "cpaA is a capreomycin acetyltransferase protein found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus in Lechuguilla Cave, NM, USA. Confers resistance to capreomycin, an aminoglycoside antibiotic. Described by Pawlowski et al. 2016." [PMID:27929110] is_a: ARO:3004257 ! cpa acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3003993 ! capreomycin synonym: "cpaA" EXACT CARD_Short_Name [] [Term] id: ARO:3003995 name: Clostridioides difficile gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Amino acid substitutions in Clostridioides difficile gyrase subunit A which when present confer functional resistance to fluoroquinolone antibiotics." [PMID:12384345, PMID:11451695, PMID:18480338, PMID:20226332, PMID:19818865, PMID:27842877, PMID:19364867, PMID:12848728, PMID:22508299] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000659 ! gatifloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin synonym: "Cdif_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3003997 name: amoxicillin-clavulanic acid namespace: antibiotic_resistance def: "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate)." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000064 ! amoxicillin relationship: has_part ARO:0000079 ! clavulanic acid synonym: "AMC" EXACT [] synonym: "amoxicillin-clavulanate" EXACT [] synonym: "clavamox" EXACT [] synonym: "co-amoxiclav" EXACT [] xref: pubchem.compound:23665637 [Term] id: ARO:3003998 name: ampicillin-sulbactam namespace: antibiotic_resistance def: "An antibiotic mixture containing the penicillin-derived beta-lactam antibiotic Ampicillin and the beta-lactamase inhibitor Sulbactam. Also known as Unasyn and/or Ampictam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000587 ! sulbactam relationship: has_part ARO:3000637 ! ampicillin synonym: "Ampictam" EXACT [] synonym: "SAM" EXACT [] synonym: "Unasyn" EXACT [] [Term] id: ARO:3003999 name: cefamandole namespace: antibiotic_resistance def: "Cefamandole is a second-generation cephalosporin-class beta-lactam antibiotic." [] is_a: ARO:0000032 ! cephalosporin synonym: "FAM" EXACT [] xref: pubchem.compound:456255 [Term] id: ARO:3004000 name: cefetamet namespace: antibiotic_resistance def: "Cefetamet is a third-generation semi-synthetic beta-lactam antibiotic that inactivates inner cell wall PBPs through targeting binding, resulting in cell lysis." [PMID:2504597] is_a: ARO:0000032 ! cephalosporin synonym: "FET" EXACT [] synonym: "cefetametum" EXACT [] xref: pubchem.compound:5487888 [Term] id: ARO:3004001 name: cefmetazole namespace: antibiotic_resistance def: "Cefmetazole is a semi-synthetic cephamycin antibiotic with broad spectrum antibiotic activity against both gram-positive and gram-negative bacteria, that disrupt cell wall synthesis through binding to PBPs causing cell lysis." [] is_a: ARO:0000044 ! cephamycin synonym: "CMZ" EXACT [] xref: pubchem.compound:42008 [Term] id: ARO:3004002 name: cefonicid namespace: antibiotic_resistance def: "Cefonicid is a second-generation cephalosporin-class beta-lactam antibiotic with broad spectrum activity. Particularly used against urinary tract infections and lower respiratory infections. Causes cell lysis by inactivation of PBPs through binding, inhibiting peptidoglycan synthesis." [] is_a: ARO:0000032 ! cephalosporin synonym: "CID" EXACT [] synonym: "cefonicide" EXACT [] xref: pubchem.compound:43594 [Term] id: ARO:3004003 name: cefoperazone namespace: antibiotic_resistance def: "Cefoperazone is a semi-synthetic cephalosporin containing a tetrazolyl moiety that is resistant to beta-lactamases. Particularly used for treatment of Pseudomonas spp. infections." [PMID:6221381] is_a: ARO:0000032 ! cephalosporin synonym: "CFP" EXACT [] synonym: "cefoperazine" EXACT [] xref: pubchem.compound:44187 [Term] id: ARO:3004004 name: cefotetan namespace: antibiotic_resistance def: "Cefotetan is a cephamycin-class beta-lactam antibiotic that is highly resistant to beta-lactamases and effective against a wide range of gram-negative and gram-positive bacteria." [] is_a: ARO:0000044 ! cephamycin synonym: "CTT" EXACT [] synonym: "Cefotetanum" EXACT [] xref: pubchem.compound:53025 [Term] id: ARO:3004005 name: cefprozil namespace: antibiotic_resistance def: "Cefprozil is a cephalosporin and beta-lactam antibiotic with bactericidal activity. It selectively binds to PBPs and inhibits peptidoglycan synthesis, a major cell wall component, resulting in cell lysis." [PMID:12841400] is_a: ARO:0000032 ! cephalosporin synonym: "Brisoral" EXACT [] synonym: "CPR" EXACT [] synonym: "Cefzil" EXACT [] xref: pubchem.compound:5281006 [Term] id: ARO:3004006 name: ceftiofur namespace: antibiotic_resistance def: "Ceftiofur is a third-generation broad spectrum cephalosporin and beta-lactam antibiotic. It causes cell lysis by disrupting peptidoglycan cross-linkage and cell wall formation by binding to PBPs." [PMID:3631686] is_a: ARO:0000032 ! cephalosporin synonym: "Excenel" EXACT [] synonym: "Naxcel" EXACT [] xref: pubchem.compound:6328657 [Term] id: ARO:3004007 name: ceftizoxime namespace: antibiotic_resistance def: "Ceftizoxime is a third-generation cephalosporin and broad spectrum beta-lactam antibiotic. Ceftizoxime causes bacterial cell lysis through peptidoglycan cross-linking inhibition by binding to PBPs." [PMID:6326062] is_a: ARO:0000032 ! cephalosporin synonym: "ZOX" EXACT [] xref: pubchem.compound:6533629 [Term] id: ARO:3004008 name: cephapirin namespace: antibiotic_resistance def: "Cephapirin is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Inactivation of penicillin-binding proteins through cephapirin binding disrupts peptidoglycan cross-linking, resulting in cell lysis." [] is_a: ARO:0000032 ! cephalosporin synonym: "HAP" EXACT [] synonym: "cefadyl" EXACT [] synonym: "cefapirin" EXACT [] xref: pubchem.compound:30699 [Term] id: ARO:3004009 name: cefradine namespace: antibiotic_resistance def: "Cefradine is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Cefradine binding to penicillin-binding proteins disrupts cell wall peptidoglycan cross-linkage, resulting in cell lysis." [PMID:4572639] is_a: ARO:0000032 ! cephalosporin synonym: "Cephradine" EXACT [] synonym: "RAD" EXACT [] xref: pubchem.compound:38103 [Term] id: ARO:3004010 name: cinoxacin namespace: antibiotic_resistance def: "Cinoxacin is a fluoroquinolone antibiotic primarily used for the treatment of urinary tract infections in adults. Cinoxacin binds to DNA gyrase, resulting in double-stranded DNA breaks and cell death." [PMID:7017171] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Azolinic acid" EXACT [] synonym: "CIN" EXACT [] xref: pubchem.compound:2762 [Term] id: ARO:3004011 name: clinafloxacin namespace: antibiotic_resistance def: "Clinafloxacin is a fluoroquinolone antibiotic and gyrase (DNA topoisomerase II) inhibitor. It binds to DNA gyrase and disrupts replication by causing double-stranded DNA breaks, resulting in cell death." [PMID:3142350] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "CLX" EXACT [] xref: pubchem.compound:60063 [Term] id: ARO:3004012 name: clofazimine namespace: antibiotic_resistance def: "Clofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death." [PMID:7829710] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Lampren" EXACT [] synonym: "Lamprene" EXACT [] xref: pubchem.compound:2794 [Term] id: ARO:3004013 name: fleroxacin namespace: antibiotic_resistance def: "Fleroxacin is a broad spectrum fluoroquinolone antibiotic that inhibits the DNA supercoiling activity of bacterial DNA gyrase, resulting in double-stranded DNA breaks and subsequent cell death." [PMID:2112571] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Megalocin" EXACT [] synonym: "Quinodis" EXACT [] xref: pubchem.compound:3357 [Term] id: ARO:3004014 name: flomoxef namespace: antibiotic_resistance def: "Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria." [PMID:37610203, PMID:4008339] is_a: ARO:3007676 ! oxacephem xref: pubchem.compound:65864 [Term] id: ARO:3004015 name: gentamicin A namespace: antibiotic_resistance def: "Gentamicin A is part of a complex of broad spectrum aminoglycoside antibiotics. Gentamicin inhibits protein synthesis, resulting in bacterial cell death." [PMID:10103173, PMID:11083623] is_a: ARO:3007382 ! gentamicin synonym: "Garamycin" EXACT [] xref: pubchem.compound:12810388 [Term] id: ARO:3004016 name: loracarbef namespace: antibiotic_resistance def: "Loracarbef is a second-generation cephalosporin (carbacephem) and broad spectrum beta-lactam antibiotic. Loracarbef inhibits PBPs through binding, disrupting peptidoglycan cell wall cross-linkage and resulting in cell death." [PMID:8453172, PMID:3501757] is_a: ARO:0000032 ! cephalosporin synonym: "Lorabid" EXACT [] synonym: "Loracarbefum" EXACT [] xref: pubchem.compound:5284585 [Term] id: ARO:3004017 name: moxalactam namespace: antibiotic_resistance def: "Moxalactam (Latamoxef) is a broad spectrum cephalosporin (oxacephem) and beta-lactam antibiotic. Moxalactam binding to PBPs inhibits peptidoglycan cross-linkage in the cell wall, resulting in cell death. Moxalactam is proposed to be effective against meningitides as it passes the blood-brain barrier." [PMID:315938, PMID:6218558] is_a: ARO:0000032 ! cephalosporin synonym: "Latamoxef" EXACT [] xref: pubchem.compound:47499 [Term] id: ARO:3004018 name: nafcillin namespace: antibiotic_resistance def: "Nafcillin is a penicillin-class narrow-spectrum beta-lactam antibiotic. It inhibits cell wall synthesis and peptidoglycan cross-linkage through binding to PBPs, similarly to other penicillin-like antibiotics." [] is_a: ARO:3000008 ! penam synonym: "Nafcil" EXACT [] xref: pubchem.compound:8982 [Term] id: ARO:3004019 name: para-aminosalicylic acid namespace: antibiotic_resistance def: "Para-aminosalicylic acid (PAS) is an anti-tubercular antibiotic agent, often used in conjunction with Isoniazid for treatment of M. tuberculosis infections. PAS diminishes bacterial cell growth by limiting folic acid production." [] is_a: ARO:3007159 ! salicylic acid antibiotic synonym: "4-aminosalicylic acid" EXACT [] xref: pubchem.compound:4649 [Term] id: ARO:3004020 name: piperacillin-sulbactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the beta-lactam penam antibiotic Piperacillin and the beta-lactamase inhibitor sulbactam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000078 ! piperacillin relationship: has_part ARO:3000587 ! sulbactam [Term] id: ARO:3004021 name: piperacillin-tazobactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the penam beta-lactam antibiotic Piperacillin and the beta-lactamase inhibitor Tazobactam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000077 ! tazobactam relationship: has_part ARO:0000078 ! piperacillin synonym: "Tazocin" EXACT [] synonym: "Zosyn" EXACT [] xref: pubchem.compound:23724843 [Term] id: ARO:3004022 name: quinupristin-dalfopristin namespace: antibiotic_resistance def: "An antibiotic cocktail of the streptogramin A dalfopristin and the streptogramin B quinupristin antibiotics. Used particularly to treat MRSA and vancomycin-resistant Enterococcus." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000584 ! quinupristin relationship: has_part ARO:3000674 ! dalfopristin synonym: "Synercid" EXACT [] xref: pubchem.compound:25199981 [Term] id: ARO:3004023 name: ticarcillin-clavulanic acid namespace: antibiotic_resistance def: "An antibiotic cocktail containing the beta-lactam antibiotic ticarcillin and the beta-lactamase inhibitor clavulanic acid (clavulanate)." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000079 ! clavulanic acid relationship: has_part ARO:3003832 ! ticarcillin synonym: "co-ticarclav" EXACT [] xref: pubchem.compound:6437075 [Term] id: ARO:3004024 name: trimethoprim-sulfamethoxazole namespace: antibiotic_resistance def: "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX)." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000188 ! trimethoprim relationship: has_part ARO:3000329 ! sulfamethoxazole synonym: "cotrimoxazole" EXACT [] xref: pubchem.compound:358641 [Term] id: ARO:3004025 name: prothionamide namespace: antibiotic_resistance def: "Prothionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections." [PMID:6459296] is_a: ARO:3007156 ! thioamide antibiotic synonym: "protionamide" EXACT [] xref: pubchem.compound:666418 [Term] id: ARO:3004026 name: tinidazole namespace: antibiotic_resistance def: "Tinidazole is a nitroimidazole anti-parasitic drug. It is used in the treatment of protozoan infections." [PMID:3733593] is_a: ARO:3004115 ! nitroimidazole antibiotic synonym: "Fasigyn" EXACT [] synonym: "Simplotan" EXACT [] synonym: "Sporinex" EXACT [] synonym: "Tindamax" EXACT [] xref: pubchem.compound:5479 [Term] id: ARO:3004030 name: RosAB namespace: antibiotic_resistance def: "An efflux pump/potassium antiporter system (RosAB) formed by the RosA and RosB proteins found in Yersinia." [PMID:12010497, PMID:10931306] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000625 ! polymyxin B1 relationship: confers_resistance_to_antibiotic ARO:3000626 ! polymyxin B2 relationship: confers_resistance_to_antibiotic ARO:3000627 ! polymyxin B3 relationship: confers_resistance_to_antibiotic ARO:3000628 ! polymyxin B4 [Term] id: ARO:3004031 name: tetAB(46) namespace: antibiotic_resistance def: "tetAB(46) is a heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. Both tetA(46) and tetB(46) genes are required for resistance." [PMID:22941900] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline [Term] id: ARO:3004032 name: tetA(46) namespace: antibiotic_resistance def: "tetA(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity." [PMID:22941900] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004031 ! tetAB(46) synonym: "tetA(46)" EXACT CARD_Short_Name [] [Term] id: ARO:3004033 name: tetB(46) namespace: antibiotic_resistance def: "tetB(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity." [PMID:22941900] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004031 ! tetAB(46) synonym: "tetB(46)" EXACT CARD_Short_Name [] [Term] id: ARO:3004034 name: tetAB(60) namespace: antibiotic_resistance def: "tetAB(60) is an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli. Both tetA(60) and tetB(60) are required for resistance." [PMID:27999567] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline [Term] id: ARO:3004035 name: tetA(60) namespace: antibiotic_resistance def: "tetA(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance." [PMID:27999567] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004034 ! tetAB(60) synonym: "tetA(60)" EXACT CARD_Short_Name [] [Term] id: ARO:3004036 name: tetB(60) namespace: antibiotic_resistance def: "tetB(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance." [PMID:27999567] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004034 ! tetAB(60) synonym: "tetB(60)" EXACT CARD_Short_Name [] [Term] id: ARO:3004038 name: Pseudomonas aeruginosa emrE namespace: antibiotic_resistance def: "EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. Confers resistance to tetraphenylphosphonium, methyl viologen, gentamicin, kanamycin, and neomycin." [PMID:12499164] is_a: ARO:3000264 ! emrE relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C synonym: "PAsmr" EXACT [] synonym: "Pae-Emre" EXACT [] synonym: "Paer_emrE" EXACT CARD_Short_Name [] xref: PDB:3B61 [Term] id: ARO:3004039 name: Escherichia coli emrE namespace: antibiotic_resistance def: "Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation." [PMID:1936950] is_a: ARO:3000264 ! emrE relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Ecol_emrE" EXACT CARD_Short_Name [] xref: PDB:3B61 [Term] id: ARO:3004040 name: rifampin phosphotransferase namespace: antibiotic_resistance def: "Enzymes, protein or other gene products that inactivate rifampin (rifamycin) antibiotics through phosphorylation of the antibiotic at the 21-OH position." [] is_a: ARO:3000576 ! rifampin inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic relationship: participates_in ARO:3000105 ! phosphorylation of antibiotic conferring resistance synonym: "rph" EXACT [] [Term] id: ARO:3004041 name: Klebsiella pneumoniae acrA namespace: antibiotic_resistance def: "AcrA is a subunit of the AcrAB multidrug efflux system that is found in K. pneumoniae, which is encoded by the acrRAB operon." [PMID:24327941, PMID:19858254] is_a: ARO:3000207 ! acrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Kpne_acrA" EXACT CARD_Short_Name [] xref: PDB:2F1M [Term] id: ARO:3004042 name: Enterobacter cloacae acrA namespace: antibiotic_resistance def: "AcrA is a subunit of the AcrAB-TolC multidrug efflux system in E. cloacae." [PMID:12121946, PMID:17536927] is_a: ARO:3000207 ! acrA relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline synonym: "Eclo_acrA" EXACT CARD_Short_Name [] xref: PDB:2F1M [Term] id: ARO:3004043 name: Escherichia coli acrA namespace: antibiotic_resistance def: "AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli." [PMID:11321576, PMID:24747401, PMID:12363006] is_a: ARO:3000207 ! acrA synonym: "Ecol_acrA" EXACT CARD_Short_Name [] xref: PDB:2F1M [Term] id: ARO:3004044 name: antibiotic sensitive fabI namespace: antibiotic_resistance def: "fabI is a bacterial enoyl-acyl carrier reductase (ENR) isozyme. As with other ENRs, mutations in fabI can confer resistance to the biocide triclosan." [] is_a: ARO:3000872 ! antibiotic sensitive enoyl-acyl carrier reductase [Term] id: ARO:3004045 name: Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan namespace: antibiotic_resistance def: "fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid." [PMID:27577999] is_a: ARO:3004270 ! antibiotic resistant fabI relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan synonym: "Ecol_fabI_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004046 name: kdpDE namespace: antibiotic_resistance def: "kdpDE is a two-component regulatory system in Escherichia coli, well studied for its role in potassium transport and homeostasis. kdpE is also implicated in virulence loci regulation and overexpression of kdpE is shown to confer resistance to aminoglycoside antibiotics." [PMID:23555240] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004047 name: kdpD namespace: antibiotic_resistance def: "kdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE." [PMID:23555240] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004046 ! kdpDE synonym: "kdpD" EXACT CARD_Short_Name [] [Term] id: ARO:3004048 name: MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin namespace: antibiotic_resistance def: "MexAB-OprM efflux pump system with a prematurely terminated MexR confers resistance to meropenem and ciprofloxacin." [PMID:26866484] is_a: ARO:3000386 ! MexAB-OprM relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem synonym: "Paer_tMexR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004049 name: Escherichia coli fabG mutations conferring resistance to triclosan namespace: antibiotic_resistance def: "fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis.The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan." [PMID:27577999] is_a: ARO:3004284 ! antibiotic resistant fabG relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan synonym: "Ecol_fabG_TRC" EXACT CARD_Short_Name [] [Term] id: ARO:3004050 name: antibiotic sensitive fabG namespace: antibiotic_resistance def: "fabG is a bacterial 3-oxoacyl enoyl-acyl carrier reductase (ENR) isozyme. As with other ENRs, mutations in fabG are shown to confer resistance to the biocide triclosan." [PMID:27577999] is_a: ARO:3000872 ! antibiotic sensitive enoyl-acyl carrier reductase [Term] id: ARO:3004051 name: MexAB-OprM with NalC mutations conferring resistance to aztreonam namespace: antibiotic_resistance def: "MexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains." [PMID:15387820, PMID:27412168] is_a: ARO:3000386 ! MexAB-OprM relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3004024 ! trimethoprim-sulfamethoxazole synonym: "Paer_NalC_ATM" EXACT CARD_Short_Name [] [Term] id: ARO:3004052 name: MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics namespace: antibiotic_resistance def: "MexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC." [PMID:15855496] is_a: ARO:3000386 ! MexAB-OprM relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin relationship: confers_resistance_to_antibiotic ARO:3004024 ! trimethoprim-sulfamethoxazole synonym: "Paer_NalD_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004053 name: MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam namespace: antibiotic_resistance def: "CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR." [PMID:27736975] is_a: ARO:3000386 ! MexAB-OprM relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3004024 ! trimethoprim-sulfamethoxazole synonym: "Paer_CpxR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004054 name: Pseudomonas aeruginosa CpxR namespace: antibiotic_resistance def: "CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR." [PMID:27736975] is_a: ARO:3000831 ! CpxR relationship: part_of ARO:3004053 ! MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam synonym: "Paer_CpxR" EXACT CARD_Short_Name [] [Term] id: ARO:3004055 name: Escherichia coli CpxR namespace: antibiotic_resistance def: "The Escherichia coli CpxR/CpxA system responds to general periplasmic stress and has been used as a model two-component system for transcription regulation in bacteria. CpxR/CpxA system facilitates Salmonella and E. coli resistance to cationic antimicrobial peptides.The CpxR/CpxA system can activate transcription of marRAB operon, thus facilitating multidrug-resistant regulator to enhance expression of TolC-dependent tripartite multidrug transporters." [PMID:25294881] is_a: ARO:3000831 ! CpxR synonym: "Ecol_CpxR" EXACT CARD_Short_Name [] [Term] id: ARO:3004056 name: ArmR namespace: antibiotic_resistance def: "ArmR, a 53-amino-acid antirepressor, allosterically inhibits MexR dimer-DNA binding by occupying a hydrophobic binding cavity within the center of the MexR dimer. ArmR up-regulation and MexR-ArmR complex formation have previously been shown to upregulate MexAB-OprM." [PMID:17545281, PMID:18812515] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000386 ! MexAB-OprM synonym: "ArmR" EXACT CARD_Short_Name [] [Term] id: ARO:3004057 name: 23S rRNA with mutation conferring resistance to linezolid antibiotics namespace: antibiotic_resistance def: "Point mutations in the 23S rRNA subunit may confer resistance to linezolid and other oxazolidinone antibiotics." [PMID:27727405] is_a: ARO:3000336 ! 23S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic relationship: confers_resistance_to_drug_class ARO:3000079 ! oxazolidinone antibiotic relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic relationship: confers_resistance_to_drug_class ARO:3000387 ! phenicol antibiotic relationship: confers_resistance_to_drug_class ARO:3000670 ! pleuromutilin antibiotic [Term] id: ARO:3004058 name: Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid namespace: antibiotic_resistance def: "Point mutations in the 23S rRNA subunit of the large ribosomal bacterial subunit in Staphylococcus aureus, which confer resistance to linezolid by disrupting antibiotic target binding." [PMID:27727405] is_a: ARO:3004057 ! 23S rRNA with mutation conferring resistance to linezolid antibiotics relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid synonym: "Saur_23S_LZD" EXACT CARD_Short_Name [] [Term] id: ARO:3004059 name: Type A NfxB namespace: antibiotic_resistance def: "Type A NfxB mutants are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB)." [PMID:8849250] is_a: ARO:3000820 ! NfxB relationship: part_of ARO:3004061 ! MexCD-OprJ with type A NfxB mutation relationship: regulates ARO:3000797 ! MexCD-OprJ synonym: "Type_A_NfxB" EXACT CARD_Short_Name [] synonym: "esrC" EXACT [] [Term] id: ARO:3004060 name: Type B NfxB namespace: antibiotic_resistance def: "Type B NfxB mutants are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. The mutation at the 46th amino acid position is sufficient for overproduction of OprJ and the multidrug resistance. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB)." [PMID:9449262, PMID:8849250] is_a: ARO:3000820 ! NfxB relationship: part_of ARO:3004062 ! MexCD-OprJ with type B NfxB mutation relationship: regulates ARO:3000797 ! MexCD-OprJ synonym: "Type_B_NfxB" EXACT CARD_Short_Name [] synonym: "esrC" EXACT [] [Term] id: ARO:3004061 name: MexCD-OprJ with type A NfxB mutation namespace: antibiotic_resistance def: "MexCD–OprJ with type A NfxB phenotype are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1." [PMID:8849250] is_a: ARO:3000797 ! MexCD-OprJ relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin synonym: "Paer_NfxBa_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004062 name: MexCD-OprJ with type B NfxB mutation namespace: antibiotic_resistance def: "MexCD-OprJ with Type B NfxB mutions are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1." [PMID:8849250] is_a: ARO:3000797 ! MexCD-OprJ relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin synonym: "Paer_NfxBb_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004063 name: EdeQ namespace: antibiotic_resistance def: "EdeQ is an N-acetyltransferase enzyme that confers high-level self-resistance to edeine in Brevibacillus brevis, a natural edeine producer. EdeQ converts active edeine to N-acetyledeine, which is ineffective in vivo." [PMID:23891151] is_a: ARO:3000492 ! gene involved in self-resistance to antibiotic is_a: ARO:3004064 ! Edeine acetyltransferase relationship: confers_resistance_to_antibiotic ARO:3000130 ! edeine A relationship: confers_resistance_to_antibiotic ARO:3000134 ! edeine B relationship: confers_resistance_to_antibiotic ARO:3000135 ! edeine D relationship: confers_resistance_to_antibiotic ARO:3000136 ! edeine F synonym: "EdeQ" EXACT CARD_Short_Name [] [Term] id: ARO:3004064 name: Edeine acetyltransferase namespace: antibiotic_resistance def: "Edeine acetyltransferase enzymes catalyze the transfer of an acetyl group to active edeine, converting it to an inactive form in vivo. This mechanism is used for high-level self-resistance in edeine-producing Brevibacillus spp." [PMID:23891151] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:3000130 ! edeine A relationship: confers_resistance_to_antibiotic ARO:3000134 ! edeine B relationship: confers_resistance_to_antibiotic ARO:3000135 ! edeine D relationship: confers_resistance_to_antibiotic ARO:3000136 ! edeine F relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic relationship: participates_in ARO:3000106 ! acylation of antibiotic conferring resistance [Term] id: ARO:3004066 name: MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim namespace: antibiotic_resistance def: "The MexEF–OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin." [PMID:26833155] is_a: ARO:3000798 ! MexEF-OprN relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Paer_MexT_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004067 name: MUS beta-lactamase namespace: antibiotic_resistance def: "Subclass B1 (metallo-) beta-lactamases found in Myroides spp., which confer resistance to carbapenam class beta-lactamase antibiotics." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004068 name: MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim namespace: antibiotic_resistance def: "The MexEF–OprN efflux pump with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin. The model includes the MexT regulator, as MexS is suggested to inactivate MexT." [PMID:26833155] is_a: ARO:3000798 ! MexEF-OprN relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Paer_MexS_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004069 name: MvaT namespace: antibiotic_resistance def: "MvaT, a global regulator of virulence genes in P. aeruginosa, has also shown to be able to repress the expression of the MexEF-OprN pump." [PMID:16448502] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004070 ! MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin relationship: regulates ARO:3000798 ! MexEF-OprN synonym: "MvaT" EXACT CARD_Short_Name [] [Term] id: ARO:3004070 name: MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin namespace: antibiotic_resistance def: "A deletion of MvaT results in the overexpression of MexEF-OprN conferring resistance to chloramphenicol and norfloxacin." [PMID:21911574, PMID:16448502] is_a: ARO:3000798 ! MexEF-OprN relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "Paer_MvaT_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004072 name: OpmB namespace: antibiotic_resistance def: "OpmB is an outer membrane efflux protein in Pseudomonas aeruginosa that shows functional cooperation with MuxABC, to form the efflux pump system MuxABC-OpmB." [PMID:12445646] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004076 ! MuxABC-OpmB synonym: "OpmB" EXACT CARD_Short_Name [] synonym: "PA2525" EXACT [] [Term] id: ARO:3004073 name: MuxA namespace: antibiotic_resistance def: "MuxA is a membrane fusion protein component of the efflux pump system MuxABC-OpmB in Pseudomonas aeruginosa." [PMID:19713238] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004076 ! MuxABC-OpmB synonym: "MuxA" EXACT CARD_Short_Name [] synonym: "PA2528" EXACT [] [Term] id: ARO:3004074 name: MuxB namespace: antibiotic_resistance def: "MuxB is one of the two necessary RND components in the Pseudomonas aeruginosa efflux pump system MuxABC-OpmB." [PMID:19713238] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004076 ! MuxABC-OpmB synonym: "MuxB" EXACT CARD_Short_Name [] synonym: "PA2527" EXACT [] [Term] id: ARO:3004075 name: MuxC namespace: antibiotic_resistance def: "MuxC is one of the two necessary RND components of the MuxABC-OpmB efflux pumps system in Pseudomonas aeruginosa." [PMID:19713238] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004076 ! MuxABC-OpmB synonym: "MuxC" EXACT CARD_Short_Name [] synonym: "PA2526" EXACT [] [Term] id: ARO:3004076 name: MuxABC-OpmB namespace: antibiotic_resistance def: "MuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin." [PMID:19713238] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3001227 ! kitasamycin relationship: confers_resistance_to_antibiotic ARO:3003701 ! rokitamycin synonym: "MuxABC-OpmB" EXACT CARD_Short_Name [] [Term] id: ARO:3004077 name: PmpM namespace: antibiotic_resistance def: "PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G." [PMID:14679249] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:3003823 ! benzalkonium chloride relationship: confers_resistance_to_antibiotic ARO:3007039 ! chlorhexidine relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "PA1361" EXACT [] synonym: "PmpM" EXACT CARD_Short_Name [] [Term] id: ARO:3004080 name: MexAB-OprM with MexR mutations confers resistance to multiple antibiotics namespace: antibiotic_resistance def: "MexAB-OprM efflux pump system with MexR mutations confers resistance to multiple antibiotics in P. aeruginosa." [PMID:17586626, PMID:9449262] is_a: ARO:3000386 ! MexAB-OprM relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3003708 ! panipenem relationship: confers_resistance_to_antibiotic ARO:3004024 ! trimethoprim-sulfamethoxazole relationship: confers_resistance_to_drug_class ARO:3000282 ! sulfonamide antibiotic relationship: confers_resistance_to_drug_class ARO:3003706 ! penem synonym: "Paer_MexR_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004082 name: AcrAD-TolC namespace: antibiotic_resistance def: "AcrAD-TolC efflux pump system in E. coli from the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides." [PMID:14706082, PMID:10692383] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic synonym: "AcrAD-TolC" EXACT CARD_Short_Name [] [Term] id: ARO:3004083 name: AcrEF-TolC confers resistance to ciprofloxacin namespace: antibiotic_resistance def: "AcrEF-TolC efflux pump system of E. coli confers resistance to fluoroquinolones (ciprofloxacin)." [PMID:10952561, PMID:16267305] is_a: ARO:3000503 ! AcrEF-TolC relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "AcrEF_TolC_CIP" EXACT CARD_Short_Name [] [Term] id: ARO:3004085 name: lnuG namespace: antibiotic_resistance def: "lnuG is a transposon-mediated lincosamide nucleotidyltransferase found in Enterococcus faecalis on Tn6260." [PMID:28039271] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin synonym: "lnuG" EXACT CARD_Short_Name [] [Term] id: ARO:3004086 name: APH(3')-VIIIb namespace: antibiotic_resistance def: "APH(3')-VIIIb is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Acinetobacter rudis." [PMID:27965516] is_a: ARO:3000126 ! APH(3') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "APH(3')-VIIIb" EXACT CARD_Short_Name [] [Term] id: ARO:3004087 name: APH(3')-IXa namespace: antibiotic_resistance def: "APH(3')-IXa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides." [PMID:27965516] is_a: ARO:3000126 ! APH(3') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "APH(3')-IXa" EXACT CARD_Short_Name [] [Term] id: ARO:3004088 name: lefamulin namespace: antibiotic_resistance def: "Lefamulin is a semi-synthetic pleuromutilin compound highly active against multi-resistant pathogens." [PMID:27958389, PMID:32493034] is_a: ARO:3000670 ! pleuromutilin antibiotic xref: pubchem.compound:25185057 [Term] id: ARO:3004089 name: ANT(3'')-IIa namespace: antibiotic_resistance def: "ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms." [PMID:28152054] is_a: ARO:3004275 ! ANT(3'') relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "ANT(3'')-IIa" EXACT CARD_Short_Name [] synonym: "ANT(9)(3'')" EXACT [] synonym: "aadA1-pm" EXACT [] [Term] id: ARO:3004090 name: ANT(3'')-IIb namespace: antibiotic_resistance def: "ANT(3'')-IIb is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms." [PMID:28152054] is_a: ARO:3004275 ! ANT(3'') relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "ANT(3'')-IIb" EXACT CARD_Short_Name [] [Term] id: ARO:3004091 name: ANT(3'')-IIc namespace: antibiotic_resistance def: "ANT(3'')-IIc is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms." [PMID:28152054] is_a: ARO:3004275 ! ANT(3'') relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "ANT(3'')-IIc" EXACT CARD_Short_Name [] [Term] id: ARO:3004092 name: HMB-1 namespace: antibiotic_resistance def: "Shotgun cloning of beta-lactam resistant P. aeruginosa NRZ-03096 yielded a clone producing a novel subclass B1 enzyme with only 74.3% identity to the next nearest relative, KHM-1. The novel MBL was named HMB-1 (for Hamburg MBL). HMB-1 gene was chromosomally located as part of a Tn 3 family transposon that was named Tn 6345, where expression of bla HMB-1 in E. coli TOP10 led to increased resistance to beta-lactams." [PMID:28065891] is_a: ARO:3004209 ! HMB beta-lactamase synonym: "HMB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004093 name: NDM-17 namespace: antibiotic_resistance def: "NDM-17 is a metallo-beta-lactamase isolated from Escherichia coli with enhanced carbapenemase activity compared to NDM-1." [PMID:28242668] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-17" EXACT CARD_Short_Name [] [Term] id: ARO:3004094 name: Erm(48) namespace: antibiotic_resistance def: "Erm(48) is a macrolide-lincosamide-streptogramin resistance gene identified on resistance plasmid pJW2311." [PMID:28438941] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA synonym: "Erm(48)" EXACT CARD_Short_Name [] [Term] id: ARO:3004096 name: daptomycin resistant CdsA namespace: antibiotic_resistance def: "Mutations to the CdsA phosphatidate cytidylyltransferase conferring resistance to daptomycin." [PMID:28115347] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004097 name: Streptococcus mitis CdsA with mutation conferring daptomycin resistance namespace: antibiotic_resistance def: "CdsA is a phosphatidate cytidylyltransferase which plays a role in the production of membrane phosphatidylglycerol and cardiolipin." [PMID:28115347] is_a: ARO:3004096 ! daptomycin resistant CdsA relationship: confers_resistance_to_antibiotic ARO:0000068 ! daptomycin synonym: "Smit_CdsA_DAP" EXACT CARD_Short_Name [] [Term] id: ARO:3004098 name: LpeAB namespace: antibiotic_resistance def: "LpeAB are components of an efflux pump, which is a macrolide resistance determinant in L. pneumophila Paris strain. Mutations observed in the upstream sequence of lpeAB operon in resistant lineages led to an overexpression of this efflux pump. Sub-inhibitory concentrations of macrolides themselves participated in upregulating this efflux and could constitute a first step in the acquisition of a high macrolide resistance level. As Lpp2879–Lpp2880 is homologous to Escherichia coli AcrAB, lpp2879–lpp2880 was renamed to lpeAB." [PMID:28137939] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic synonym: "lpp2879-lpp2880" EXACT [] [Term] id: ARO:3004099 name: LpeA namespace: antibiotic_resistance def: "LpeA is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrA in E. coli." [PMID:28137939] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004098 ! LpeAB synonym: "LpeA" EXACT CARD_Short_Name [] synonym: "lpp2879" EXACT [] [Term] id: ARO:3004100 name: LpeB namespace: antibiotic_resistance def: "LpeB is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrB in E. coli." [PMID:28137939] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004098 ! LpeAB synonym: "LpeB" EXACT CARD_Short_Name [] synonym: "lpp2880" EXACT [] [Term] id: ARO:3004101 name: MdtNOP namespace: antibiotic_resistance def: "MdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type." [PMID:19429622, PMID:8021163] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000047 ! puromycin synonym: "MdtNOP" EXACT CARD_Short_Name [] synonym: "sdsRQP" EXACT [] synonym: "ycjRQP" EXACT [] [Term] id: ARO:3004102 name: kamB namespace: antibiotic_resistance def: "Methyltransferase enzyme first described in Streptoalloteichus tenebrarius. Confers resistance to aminoglycoside antibiotics (esp. apramycin) through methylation of the 16S rRNA at A1408, thereby modifying the antibiotic target." [PMID:19589804, PMID:24963996] is_a: ARO:3004272 ! 16S rRNA methyltransferase (A1408) relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000037 ! apramycin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "kamB" EXACT CARD_Short_Name [] [Term] id: ARO:3004103 name: QepA2 namespace: antibiotic_resistance def: "QepA2 is a plasmid-mediated quinolone resistance pump found in an Escherichia coli isolate from France." [PMID:18644958] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "QepA2" EXACT CARD_Short_Name [] [Term] id: ARO:3004104 name: TMB beta-lactamase namespace: antibiotic_resistance def: "TMB-1, the first known member of the Tripoli metallo-beta-lactamase family (TMB) was isolated from Achromobacter xylosoxidans in a Tripoli central hospital. TMB-1 was located on a class 1 integron and is a chromosomally-encoded beta-lactamase capable of hydrolyzing multiple antibiotics." [PMID:22290947] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin [Term] id: ARO:3004105 name: TMB-1 namespace: antibiotic_resistance def: "TMB-1 is a TMB metallo-beta-lactamase found in Achromobacter sp." [PMID:22290947] is_a: ARO:3004104 ! TMB beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TMB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004106 name: TMB-2 namespace: antibiotic_resistance def: "TMB-2 is a TMB metallo-beta-lactamase found in Acinetobacter sp." [PMID:23390208] is_a: ARO:3004104 ! TMB beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TMB-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004107 name: Pseudomonas aeruginosa soxR namespace: antibiotic_resistance def: "SoxR is a redox-sensitive transcriptional activator that induces expression of a small regulon that includes the RND efflux pump-encoding operon mexGHI-opmD. SoxR was shown to be activated by pyocyanin." [PMID:15845502, PMID:16879411, PMID:27274079] is_a: ARO:3000836 ! soxR relationship: regulates ARO:3000799 ! MexGHI-OpmD synonym: "Paer_soxR" EXACT CARD_Short_Name [] [Term] id: ARO:3004108 name: Enterobacter cloacae rob namespace: antibiotic_resistance def: "rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA." [PMID:23006750] is_a: ARO:3000825 ! rob relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin synonym: "Eclo_rob" EXACT CARD_Short_Name [] synonym: "robA" EXACT [] [Term] id: ARO:3004109 name: Escherichia coli rob namespace: antibiotic_resistance def: "rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA." [PMID:12791142, PMID:9324261] is_a: ARO:3000825 ! rob synonym: "Ecol_rob" EXACT CARD_Short_Name [] synonym: "robA" EXACT [] [Term] id: ARO:3004110 name: MCR-2.1 namespace: antibiotic_resistance def: "MCR-2 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting in reduction of the negative charge of the cell membrane. Originally identified in a Belgian sample of Escherichia coli by Xavier et al, (2016)." [PMID:30053115, PMID:27416987, PMID:28487432] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-2" EXACT [] synonym: "MCR-2.1" EXACT CARD_Short_Name [] [Term] id: ARO:3004111 name: FosA6 namespace: antibiotic_resistance def: "FosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule." [PMID:27261267] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosA6" EXACT CARD_Short_Name [] [Term] id: ARO:3004112 name: phosphoethanolamine transferase conferring colistin resistance namespace: antibiotic_resistance def: "This group of enzymes catalyzes the addition of a phosphoethanolamine group to another molecule. The addition of this moiety to lipid A in bacterial species is often associated with polymyxin (otherwise known as colistin) resistance." [PMID:28487432, PMID:26603172] is_a: ARO:3003580 ! gene altering cell wall charge synonym: "PEtN transferase" EXACT [] [Term] id: ARO:3004113 name: FosA7 namespace: antibiotic_resistance def: "FosA7 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule." [PMID:28533247] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosA7" EXACT CARD_Short_Name [] [Term] id: ARO:3004114 name: porin OmpC namespace: antibiotic_resistance def: "In the presence of antibiotic stress, there is a coupled down-regulation of the porin OmpC with the OmpF. Mutants both lacking both OmpC and OmpF proteins are resistant to cephaloridine and cefazolin. Analyses of genes involved in the increased resistance to tetracycline suggest that the up-regulation of efflux pump genes is accompanied by a decrease of OmpF and OmpC synthesis. Homologs of OmpC have been identified in Escherichia coli, Salmonella enterica, Klebsiella aerogenes and Serratia marcescens." [PMID:17426813, PMID:23034325, PMID:6760806] is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:3004129 ! cephaloridine synonym: "porin_OmpC" EXACT CARD_Short_Name [] [Term] id: ARO:3004115 name: nitroimidazole antibiotic namespace: antibiotic_resistance def: "Nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity, classified with respect to the location of the nitro functional group." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3004116 name: nitrofuran antibiotic namespace: antibiotic_resistance def: "Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3004117 name: Vibrio cholerae OmpU namespace: antibiotic_resistance def: "A ToxR-Regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpU. OmpU also confers resistance to polymyxin B sulfate." [PMID:24943244, PMID:15155667] is_a: ARO:3004282 ! General Bacterial Porin with reduced permeability to peptide antibiotics relationship: confers_resistance_to_antibiotic ARO:3004121 ! BPI synonym: "Vcho_OmpU" EXACT CARD_Short_Name [] [Term] id: ARO:3004118 name: Vibrio cholerae OmpT namespace: antibiotic_resistance def: "A ToxR negatively regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpT, especially in the absence of OmpU." [PMID:10632889, PMID:15155667] is_a: ARO:3004282 ! General Bacterial Porin with reduced permeability to peptide antibiotics relationship: confers_resistance_to_antibiotic ARO:3004121 ! BPI synonym: "Vcho_OmpT" EXACT CARD_Short_Name [] [Term] id: ARO:3004120 name: CBP C1-aminomethylene vancomycin namespace: antibiotic_resistance def: "CBP C1-aminomethylene vancomycin is a synthetic vancomycin derivative which exhibits multiple synergistic mechanisms of action, allowing it to effectively inhibit otherwise-glycopeptide resistant Gram-positive bacteria (notably those with functioning VanA clusters)." [PMID:28559345] is_a: ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3004121 name: BPI namespace: antibiotic_resistance def: "Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. The potent (nM) cytotoxicity of BPI is limited to gram-negative bacteria (GNB), reflecting the high affinity (<10 nM) of BPI for bacterial lipopolysaccharides (LPS). Binding of BPI to live bacteria via LPS causes immediate growth arrest, actual killing coincides with later damage to the inner membrane." [PMID:9665269, PMID:28336464] is_a: ARO:3000053 ! peptide antibiotic xref: PDB:1EWF [Term] id: ARO:3004122 name: Klebsiella pneumoniae OmpK37 namespace: antibiotic_resistance def: "Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35." [PMID:10217760] is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime synonym: "Kpne_OmpK37" EXACT CARD_Short_Name [] [Term] id: ARO:3004123 name: Burkholderia pseudomallei Omp38 namespace: antibiotic_resistance def: "Heterologous expression of Burkholderia pseudomallei Omp38 (BpsOmp38) in Omp-deficient E. coli host cells lowers their permeability and in consequence, their antimicrobial susceptibility to penicillin G, cefoxitin, ceftazidime and imipenem." [PMID:14567756, PMID:24788109] is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin synonym: "Bpse_Omp38" EXACT CARD_Short_Name [] [Term] id: ARO:3004124 name: Moraxella catarrhalis M35 namespace: antibiotic_resistance def: "The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Down-regulation of M35 significantly increases the MICs of aminopenicillins, specifically amoxicillin." [PMID:20801781, PMID:16159786] is_a: ARO:3003768 ! gene conferring resistance via absence is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin synonym: "Mcat_M35_AMX" EXACT CARD_Short_Name [] [Term] id: ARO:3004125 name: 23S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Nucleotide point mutations in the 23S rRNA subunit may confer resistance to macrolide antibiotics." [PMID:11120937] is_a: ARO:3000336 ! 23S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic [Term] id: ARO:3004126 name: Escherichia coli LamB namespace: antibiotic_resistance def: "LamB is a negative regulator for antibiotic resistance, it serves as a porin to influx antibiotic. When down-regulated, it increases resistance to chlortetracycline, ciprofloxacin, balofloxacin and nalidixic acid. It also interacts with Odp1, an energy metabolic enzyme, creating a complex that decreases in antibiotic-resistant strains." [PMID:18620846, PMID:10734605, PMID:24412198] is_a: ARO:3003768 ! gene conferring resistance via absence is_a: ARO:3004279 ! Sugar Porin (SP) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3004130 ! balofloxacin synonym: "Ecol_LamB" EXACT CARD_Short_Name [] [Term] id: ARO:3004127 name: Escherichia coli mipA namespace: antibiotic_resistance def: "MltA-interacting protein (mipA), is an antibiotic resistance-related outer membrane protein. Deletion of mipA increases kanamycin, nalidixic acid and streptomycin resistance." [PMID:25940639] is_a: ARO:3003768 ! gene conferring resistance via absence is_a: ARO:3004280 ! MipA-interacting Protein relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid synonym: "Ecol_mipA" EXACT CARD_Short_Name [] [Term] id: ARO:3004128 name: Serratia marcescens Omp1 namespace: antibiotic_resistance def: "Omp1 is an outer membrane porin that confers resistance by absence in S. marcescens. Knockout, deletion or other inhibition of the omp1 gene confers resistance to certain beta-lactamase antibiotics - including Cefoxitin, Ceftriaxone, Cefotaxime, and Moxalactam - as well as Ciprofloxacin, Tetracycline, and Chloramphenicol, by preventing passage of the antibiotic into the cell." [PMID:25856195, PMID:9353750] is_a: ARO:3003768 ! gene conferring resistance via absence is_a: ARO:3004281 ! General Bacterial Porin with reduced permeability to beta-lactams relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3004017 ! moxalactam synonym: "Smar_Omp1" EXACT CARD_Short_Name [] [Term] id: ARO:3004129 name: cephaloridine namespace: antibiotic_resistance def: "Cephaloridine is a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." [PMID:5175748, PMID:2907014] is_a: ARO:0000032 ! cephalosporin synonym: "Cefaloridin" EXACT [] synonym: "Cefaloridine" EXACT [] synonym: "Cefalorizin" EXACT [] synonym: "Cephalomycine" EXACT [] synonym: "Cephaloridin" EXACT [] synonym: "Cephaloridinum" EXACT [] synonym: "Ceporin" EXACT [] xref: pubchem.compound:5773 [Term] id: ARO:3004130 name: balofloxacin namespace: antibiotic_resistance def: "Balofloxacin is an 8-methoxy fluoroquinolone antibiotic. It shows potent bactericidal activity and inhibits the supercoiling activity of DNA gyrase of S. aureus, E. coli, and P. aeruginosa." [PMID:1329626, PMID:7492097] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminopiperidine-1-yl)-4-oxoquinoline-3-carboxylic acid" EXACT [] synonym: "Q 35" EXACT [] synonym: "Q-35" EXACT [] xref: pubchem.compound:65958 [Term] id: ARO:3004131 name: Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to the macrolide-class antibiotics erythromycin and telithromycin." [PMID:1569089, PMID:3886627, PMID:10027979, PMID:6330677, PMID:11120937] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin synonym: "Ecol_23S_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004132 name: Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin namespace: antibiotic_resistance def: "Point mutation in 23S rRNA of C. reinhardtii chloroplast shown clinically to confer resistance to Erythromycin, a macrolide antibiotic." [PMID:11120937, PMID:2583478] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Crei_23S_ERY" EXACT CARD_Short_Name [] [Term] id: ARO:3004133 name: Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin namespace: antibiotic_resistance def: "Point mutation in B. hyodysenteriae 23S rRNA shown to confer resistance to tylosin and erythromycin." [PMID:11120937] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin synonym: "Bhyo_23S_TYL" EXACT CARD_Short_Name [] [Term] id: ARO:3004134 name: Helicobacter pylori 23S rRNA with mutation conferring resistance to clarithromycin namespace: antibiotic_resistance def: "Point mutations in Helicobacter pylori shown to confer resistance to clarithromycin, a macrolide antibiotic." [PMID:32708761, PMID:37485536, PMID:11120937, PMID:35002447] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Hpyl_23S_CLR" EXACT CARD_Short_Name [] [Term] id: ARO:3004135 name: Mycobacterium tuberculosis iniB with mutation conferring resistance to ethambutol namespace: antibiotic_resistance def: "Point mutations in M. tuberculosis iniB shown to confer resistance to ethambutol." [PMID:10639358] is_a: ARO:3004136 ! Ethambutol resistant iniB relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_iniB_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3004136 name: Ethambutol resistant iniB namespace: antibiotic_resistance def: "Point mutations occurring in the iniB region of the iniBAC operon shown to confer resistance to ethambutol." [PMID:10639358] is_a: ARO:3004137 ! Antibiotic resistant iniB relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic [Term] id: ARO:3004137 name: Antibiotic resistant iniB namespace: antibiotic_resistance def: "iniB, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance [Term] id: ARO:3004138 name: Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Point mutations in the 23S ribosomal RNA subunit of M. catarrhalis shown clinically to confer resistance to macrolide class antibiotics." [PMID:25923017] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Mcat_23S_MAC" EXACT CARD_Short_Name [] [Term] id: ARO:3004139 name: MCR-3.1 namespace: antibiotic_resistance def: "MCR-3 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. Originally described by Yin et al. 2017, from a porcine Escherichia coli plasmid pWJ1." [PMID:28655818] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.1" EXACT CARD_Short_Name [] [Term] id: ARO:3004140 name: hydrolysis of fusidic acid to inactive lactone derivative namespace: antibiotic_resistance def: "Enzymes shown to inactivate fusidic acid by hydrolytic cleavage from the 16 beta-position of fusidic acid and its derivatives. This converts fusidic acid to an inactivate lactone derivative, thus conferring resistance to fusidic acid." [] is_a: ARO:3000040 ! hydrolysis of antibiotic conferring resistance [Term] id: ARO:3004141 name: AxyXY-OprZ namespace: antibiotic_resistance def: "An RND-type efflux system that confers innate aminoglycoside resistance to Achromobacter spp. It has a transcriptional regulator encoded by the axyZ gene located upstream of axyXY-oprZ. In-frame axyZ gene deletion assay led to increased MICs of antibiotic substrates of the efflux system: aminoglycosides, cefepime, fluoroquinolones, tetracyclines and erythromycin, indicating that the product of axyZ negatively regulates expression of axyXY-oprZ. Moreover a 45 amino-acid substitution at position 29 of AxyZ (V29G) was identified in a clinical Achromobacter strain that occurred during the course of chronic respiratory tract colonization in a cystic fibrosis (CF) patient. This substitution, also detected in 3 other strains exposed in vitro to tobramycin, led to the increase in axyY transcription level (5 to 17-fold) together with the increase in antibiotic resistance level." [PMID:28584156] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004142 name: OprZ namespace: antibiotic_resistance def: "OprZ is the outer membrane component of the AxyXY-OprZ efflux pump system in Achromobacter spp." [PMID:28584156] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004141 ! AxyXY-OprZ synonym: "OprZ" EXACT CARD_Short_Name [] [Term] id: ARO:3004143 name: AxyX namespace: antibiotic_resistance def: "AxyX is the inner membrane transporter of the AxyXY-OprZ efflux pump system in Achromobacter spp." [PMID:28584156] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004141 ! AxyXY-OprZ synonym: "AxyX" EXACT CARD_Short_Name [] [Term] id: ARO:3004144 name: AxyY namespace: antibiotic_resistance def: "AxyY is the periplasmic adaptor protein of the AxyXY-OprZ efflux pump system in Achromobacter spp." [PMID:28584156] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3004141 ! AxyXY-OprZ synonym: "AxyY" EXACT CARD_Short_Name [] [Term] id: ARO:3004145 name: AxyZ namespace: antibiotic_resistance def: "AxyZ is a transcriptional regulator of the AxyXY-OprZ efflux pump system." [PMID:28584156] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3004141 ! AxyXY-OprZ synonym: "AxyZ" EXACT CARD_Short_Name [] [Term] id: ARO:3004146 name: cfrC namespace: antibiotic_resistance def: "A cfr-like 23S rRNA methyltransferase shown to confer resistance to linezolid and phenicol antibiotics, including florfenicol and chloramphenicol, in Clostridium." [PMID:28663118] is_a: ARO:3004610 ! cfr(C) Group relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol synonym: "cfr(C)" EXACT [] synonym: "cfrC" EXACT CARD_Short_Name [] [Term] id: ARO:3004149 name: Escherichia coli 23S rRNA with mutation conferring resistance to clindamycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clindamycin, a lincosamide antibiotic." [PMID:1531223] is_a: ARO:3004187 ! 23S rRNA with mutation conferring resistance to lincosamide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "Ecol_23S_CLI" EXACT CARD_Short_Name [] [Term] id: ARO:3004150 name: Escherichia coli 23S rRNA with mutation conferring resistance to chloramphenicol namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to chloramphenicol." [PMID:3886627] is_a: ARO:3004188 ! 23S rRNA with mutation conferring resistance to phenicol antibiotics relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Ecol_23S_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004152 name: aminosalicylate resistant thymidylate synthase namespace: antibiotic_resistance def: "Antibiotic resistant form of thymidylate synthase (synthetase), an enzyme that catalyzes the conversion of dUMP to dTMP in nucleotide biosynthesis. Loss-of-function mutations in thymidylate synthase confer resistance to p-aminosalicylic acid by disrupting the substrate-binding affinity and catalytic activity." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007159 ! salicylic acid antibiotic relationship: derives_from ARO:3004154 ! antibiotic sensitive thymidylate synthase [Term] id: ARO:3004153 name: Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid namespace: antibiotic_resistance def: "Point mutations in the thymidylate synthetase thyA gene shown clinically to confer resistance to para-aminosalicylic acid. Loss-of-function mutations in thyA disrupt the catalytic activity and substrate-binding affinity, thus conferring resistance." [PMID:25421465] is_a: ARO:3004152 ! aminosalicylate resistant thymidylate synthase relationship: confers_resistance_to_antibiotic ARO:3004019 ! para-aminosalicylic acid synonym: "Mtub_thyA_PAS" EXACT CARD_Short_Name [] [Term] id: ARO:3004154 name: antibiotic sensitive thymidylate synthase namespace: antibiotic_resistance def: "Thymidylate synthase (synthetase) catalyzes the conversion of dUMP to dTMP in the nucleic acid biosynthesis pathway. Inhibition of thyA imbalances the cellular concentration of dUMP causing DNA damage." [PMID:25421465] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic synonym: "antibiotic sensitive thyA" EXACT [] [Term] id: ARO:3004155 name: aminosalicylate resistant dihydrofolate synthase namespace: antibiotic_resistance def: "Dihydrofolate synthase (synthetase) enzymes resistant to aminosalicylates (inc. para-aminosalicylic acid) caused by mutation. Dihydrofolate synthase is required for bioactivation of p-aminosalicylic acid, and mutation in dihydrofolate synthase inhibits production of the dihydrofolate analog hydroxyl-dihydrofolate, thus preventing activation and conferring resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007159 ! salicylic acid antibiotic relationship: derives_from ARO:3004156 ! antibiotic sensitive dihydrofolate synthase [Term] id: ARO:3004156 name: antibiotic sensitive dihydrofolate synthase namespace: antibiotic_resistance def: "Wild-type form of dihydrofolate synthase (synthetase) enzymes. Bioactivation of p-aminosalicylic acid occurs during the folate pathway when dihydrofolate and its analog hydroxyl-dihydrofolate are produced by dihydrofolate synthase. Disruption of this pathway by PAS results in cell damage and death." [] is_a: ARO:3000714 ! folate synthesis enzyme targeted by antibiotic [Term] id: ARO:3004157 name: Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid namespace: antibiotic_resistance def: "Point mutations in the dihydrofolate synthetase folC gene shown clinically to confer resistance to p-aminosalicylic acid or other aminosalicylates. Mutations in folC inhibit bioactivation of PAS and thus confer resistance." [PMID:25421465] is_a: ARO:3004155 ! aminosalicylate resistant dihydrofolate synthase relationship: confers_resistance_to_antibiotic ARO:3004019 ! para-aminosalicylic acid synonym: "Mtub_folC_PAS" EXACT CARD_Short_Name [] [Term] id: ARO:3004159 name: Mycoplasma gallisepticum 23S rRNA mutation conferring resistance to pleuromutilin antibiotics namespace: antibiotic_resistance def: "Point mutations in the 23S rRNA (domain V) of Mycoplasma gallisepticum can confer resistance to pleuromutilin antibiotics (tiamulin and valnemulin). The mutants also show cross-resistance to lincomycin, chloramphenicol and florfenicol." [PMID:19154331, PMID:20487023] is_a: ARO:3004178 ! 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics relationship: confers_resistance_to_antibiotic ARO:3001317 ! pleuromutilin synonym: "Mgal_23S_PLM" EXACT CARD_Short_Name [] [Term] id: ARO:3004160 name: Escherichia coli 23S rRNA with mutation conferring resistance to clarithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clarithromycin, a macrolide antibiotic." [PMID:1531223] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Ecol_23S_CLR" EXACT CARD_Short_Name [] [Term] id: ARO:3004161 name: Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Propionibacteria shown clinically to confer resistance to macrolides." [PMID:9145890] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Prop_23S_MAC" EXACT CARD_Short_Name [] [Term] id: ARO:3004163 name: Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycobacteroides abscessus shown to confer resistance to clarithromycin, a macrolide type antibiotic." [PMID:27799212, PMID:8807061] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Mabs_23S_CLR" EXACT CARD_Short_Name [] [Term] id: ARO:3004164 name: Mycobacterium avium 23S rRNA with mutation conferring resistance to clarithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycobacterium avium shown to confer resistance to clarithromycin, a macrolide type antibiotic." [PMID:8592991] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Mavi_23S_CLR" EXACT CARD_Short_Name [] [Term] id: ARO:3004165 name: Mycobacteroides chelonae 23S rRNA with mutation conferring resistance to clarithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycobacteroides chelonae shown to confer resistance to clarithromycin, a macrolide type antibiotic." [PMID:11120937] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Mche_23S_CLR" EXACT CARD_Short_Name [] [Term] id: ARO:3004166 name: Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to clarithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycobacterium intracellulare shown to confer resistance to clarithromycin, a macrolide type antibiotic." [PMID:8192472] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Mint_23S_CLR" EXACT CARD_Short_Name [] [Term] id: ARO:3004167 name: Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to azithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycobaccterium avium shown to confer resistance to azithromycin, a macrolide type antibiotic." [PMID:8192472] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Mint_23S_AZM" EXACT CARD_Short_Name [] [Term] id: ARO:3004168 name: Mycobacterium kansasii 23S rRNA with mutation conferring resistance to clarithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycobacterium kansasii shown to confer resistance to clarithromycin, a macrolide type antibiotic." [PMID:9635911] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Mkan_23S_CLR" EXACT CARD_Short_Name [] [Term] id: ARO:3004169 name: Mycolicibacterium smegmatis 23S rRNA with mutation conferring resistance to clarithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycolicibacterium smegmatis shown to confer resistance to clarithromycin, a macrolide type antibiotic." [PMID:9402018] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Msme_23S_CLR" EXACT CARD_Short_Name [] [Term] id: ARO:3004170 name: Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolide type antibiotics." [PMID:10898684] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin synonym: "Spne_23S_MAC" EXACT CARD_Short_Name [] [Term] id: ARO:3004171 name: Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Streptomyces ambofaciens shown to confer resistance to macrolide type antibiotics." [PMID:2834204] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin synonym: "Samb_23S_MAC" EXACT CARD_Short_Name [] [Term] id: ARO:3004172 name: 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics namespace: antibiotic_resistance def: "Point mutations in the 23S rRNA subunit may confer resistance to oxazolidinone antibiotics." [PMID:10986233] is_a: ARO:3000336 ! 23S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:3000079 ! oxazolidinone antibiotic [Term] id: ARO:3004173 name: Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics." [PMID:10986233] is_a: ARO:3004172 ! 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid synonym: "Ecol_23S_OXZ" EXACT CARD_Short_Name [] [Term] id: ARO:3004174 name: Chlamydia trachomatis 23S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Chlamydia trachomatis shown to confer resistance to macrolide type antibiotics." [PMID:15047540, PMID:26622462, PMID:17908942] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3001221 ! josamycin synonym: "Ctra_23S_MAC" EXACT CARD_Short_Name [] [Term] id: ARO:3004176 name: Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycoplasma hominis shown to confer resistance to macrolide type antibiotics." [PMID:12234836] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Mhom_23S_MAC" EXACT CARD_Short_Name [] [Term] id: ARO:3004177 name: Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycoplasmopsis fermentans shown to confer resistance to macrolide type antibiotics." [PMID:12234836] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin synonym: "Mfer_23S_MAC" EXACT CARD_Short_Name [] [Term] id: ARO:3004178 name: 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics namespace: antibiotic_resistance def: "Point mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics." [PMID:20487023, PMID:19154331] is_a: ARO:3000336 ! 23S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:3000670 ! pleuromutilin antibiotic [Term] id: ARO:3004179 name: Mycoplasma pneumoniae 23S rRNA mutation conferring resistance to erythromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Mycoplasma pneumoniae shown to confer resistance to erythromycin." [PMID:8593017] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Mpne_23S_ERY" EXACT CARD_Short_Name [] [Term] id: ARO:3004180 name: Halobacterium halobium 23S rRNA mutation conferring resistance to chloramphenicol namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Halobacterium halobium shown to confer resistance to chloramphenicol." [PMID:2045374] is_a: ARO:3004188 ! 23S rRNA with mutation conferring resistance to phenicol antibiotics relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Hhal_23S_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004181 name: Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolides and streptogramins types of antibiotics." [PMID:11120988] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics is_a: ARO:3004182 ! 23S rRNA with mutation conferring resistance to streptogramins antibiotics relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3001221 ! josamycin synonym: "Spne_23S_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004182 name: 23S rRNA with mutation conferring resistance to streptogramins antibiotics namespace: antibiotic_resistance def: "Nucleotide point mutations in the 23S rRNA subunit may confer resistance to streptogramins antibiotics." [PMID:11120988] is_a: ARO:3000336 ! 23S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic [Term] id: ARO:3004183 name: aminosalicylate resistant dihydrofolate reductase namespace: antibiotic_resistance def: "Antibiotic target replacement dihydrofolate reductase enzymes or domains with catalytic activity that confer resistance to aminosalicylates, esp. p-aminosalicylic acid." [] is_a: ARO:3003425 ! antibiotic resistant dihydrofolate reductase relationship: confers_resistance_to_drug_class ARO:3007159 ! salicylic acid antibiotic [Term] id: ARO:3004184 name: Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid namespace: antibiotic_resistance def: "ribD is a Mycobacterium tuberculosis riboflavin biosynthesis enzyme. Point mutations in ribD cause enzyme overexpression, which allows the C-terminal reductase domain to act as an alternative dihydrofolate reductase. Thus, mutations in ribD confer resistance to DHFR inhibitors such as para-aminosalicylic acid." [PMID:25421465] is_a: ARO:3004183 ! aminosalicylate resistant dihydrofolate reductase relationship: confers_resistance_to_antibiotic ARO:3004019 ! para-aminosalicylic acid synonym: "Mtub_ribD_PAS" EXACT CARD_Short_Name [] [Term] id: ARO:3004185 name: mecD namespace: antibiotic_resistance def: "mecD is a PBP2a variant identified on a genomic resistance island in Macrococcus caseolyticus. MecD confers resistance to methicillin and other beta-lactam antibiotics through the production of an alternative low-affinity PBP. First described by Schwendener et al. 2017 and identified from canine and bovine sources." [PMID:28272476] is_a: ARO:3001208 ! methicillin resistant PBP2 relationship: confers_resistance_to_antibiotic ARO:0000015 ! methicillin synonym: "mecD" EXACT CARD_Short_Name [] [Term] id: ARO:3004187 name: 23S rRNA with mutation conferring resistance to lincosamide antibiotics namespace: antibiotic_resistance def: "Point mutations in the 23S rRNA subunit may confer resistance to lincosamide antibiotics by reducing antibiotic binding-site affinity." [] is_a: ARO:3000336 ! 23S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic [Term] id: ARO:3004188 name: 23S rRNA with mutation conferring resistance to phenicol antibiotics namespace: antibiotic_resistance def: "Point mutations in the 23S rRNA subunit shown clinically to confer resistance to phenicol class antibiotics, including chloramphenicol and florfenicol, by disrupting antibiotic binding-site affinity." [] is_a: ARO:3000336 ! 23S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:3000387 ! phenicol antibiotic [Term] id: ARO:3004189 name: Bla2 namespace: antibiotic_resistance def: "Bla2 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which has penicillin, cephalosporin, and carbapenem-hydrolizing abilities." [PMID:12533457, PMID:27557855, PMID:12760895] is_a: ARO:3004230 ! subclass B1 Bacillus anthracis Bla beta-lactamase synonym: "Bla2" EXACT CARD_Short_Name [] [Term] id: ARO:3004190 name: BlaA beta-lactamase namespace: antibiotic_resistance def: "BlaA beta-lactamases are Class A beta-lactamases first identified in Yersinia enterocolitica and have the ability to hydrolize penicilins and cephalosporins." [PMID:1756974, PMID:11897607, PMID:237976, PMID:16553870] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004191 name: APH(2'')-If namespace: antibiotic_resistance def: "Aminoglycoside 2''-phosphotransferase identified from the gram-negative pathogen Campylobacter jejuni. APH(2'')-If was shown to confer resistance to 4,6-disubstituted antibiotics kanamycin, tobramycin, dibekacin, gentamicin and sisomicin through antibiotic phosphorylation. Described by Toth et al. 2013." [PMID:23129050] is_a: ARO:3000128 ! APH(2'') relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "APH(2'')-If" EXACT CARD_Short_Name [] [Term] id: ARO:3004192 name: CepA beta-lactamase namespace: antibiotic_resistance def: "CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin." [PMID:8285623, PMID:7517394] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004193 name: Sed beta-lactamase namespace: antibiotic_resistance def: "Sed beta-lactamases are Class A beta-lactamases that are capable of hydrolyzing benzypenicillin, cephalothin, and cloxacillin." [PMID:7517394] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004194 name: MCR-1.2 namespace: antibiotic_resistance def: "A plasmid-borne novel MCR-1 functional variant detected in a Klebsiella pneumoniae isolate collected from a rectal swab in Italy. MCR-1.2 differs from MCR-1 by a single amino acid substitution from Glutamine to Leucine at position 3 in the N-terminal region. Described by DiPilato et al. 2016." [PMID:27401575] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.2" EXACT CARD_Short_Name [] [Term] id: ARO:3004195 name: NmcA beta-lactamase namespace: antibiotic_resistance def: "nmcA beta-lactamases are chromosomal-encoded Class A beta-lactamases first isolated from Enterobacter cloacae, specifically a clinical strain known as NOR-1. nmcA beta-lactamases have been shown to hydrolyze carbapenems." [PMID:8052644] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004196 name: VCC beta-lactamase namespace: antibiotic_resistance def: "VCC beta-lactamases are Class A beta-lactamases." [PMID:26824956] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004197 name: BlaZ beta-lactamase namespace: antibiotic_resistance def: "BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus." [PMID:26305782, PMID:6793593] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004198 name: R39 beta-lactamase namespace: antibiotic_resistance def: "R39 beta-lactamases are Class A beta-lactamases encoded in Actinomadura R39 with the ability to hydrolyze penicillins." [PMID:2515104] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004199 name: CepS beta-lactamase namespace: antibiotic_resistance def: "CepS beta-lactamases are Class C beta-lactamases capable of hydrolyzing cephalosporin." [PMID:8537283] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004200 name: CfiA beta-lactamase namespace: antibiotic_resistance def: "CfiA beta-lactamases are chromosomal-encoded carbapenemase commonly found in Bacteroides fragilis isolates." [PMID:1510410] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004201 name: BlaB beta-lactamase namespace: antibiotic_resistance def: "BlaB beta-lactamases are class B beta-lactamases that are found in a variety of species and have the ability to hydrolyze penams and carbapenems." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004202 name: JOHN beta-lactamase namespace: antibiotic_resistance def: "JOHN beta-lactamases hydrolyse penicillins, narrow- and expanded-spectrum cephalosporins, and carbapenems." [PMID:12562690] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004203 name: CGB beta-lactamase namespace: antibiotic_resistance def: "CGB beta-lactamases are Class B beta-lactamases found in Chryseobacterium gleu that can hydrolyze penicillins; narrow- and expanded-spectrum cephalosporins; and carbapenems." [PMID:12183230] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004204 name: EBR beta-lactamase namespace: antibiotic_resistance def: "EBR beta-lactamases are Class B beta-lactamases first isolated from Empedobacter brevis and are able to hydrolyze penicillins, cephalosporins, and carbapenems." [PMID:12234848] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004205 name: TUS beta-lactamase namespace: antibiotic_resistance def: "TUS beta-lactamases are Class B beta-lactamases that can hydrolyze a variety of beta-lactams, such as cephems and carbapenems." [PMID:12384365, PMID:24031236] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin [Term] id: ARO:3004206 name: SIM beta-lactamase namespace: antibiotic_resistance def: "SIM beta-lactamases are Class B beta-lactamases that are capable of hydrolyzing a wide variety of beta-lactams, including penicillins, narrow- to expanded-spectrum cephalosporins, and carbapenem. The SIM family of beta-lactamases appear to be transferable through integrons." [PMID:20498315, PMID:16251286] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004207 name: KHM beta-lactamase namespace: antibiotic_resistance def: "KHM beta-lactamases are Class B beta-lactamases that can confer resistance to all classes of beta-lactams, except the monobactams." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3004208 name: DIM beta-lactamase namespace: antibiotic_resistance def: "DIM type beta-lactamases were first identified from a carbapenem-resistant Pseudomonas stutzeri strain isolated from a Dutch patient. Encoded in mobile elements, these MBLs significantly hydrolyze broad-spectrum cephalosporins and carbapenems." [PMID:20308383] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004209 name: HMB beta-lactamase namespace: antibiotic_resistance def: "First identified from a multi-drug resistant Pseudomonas aeruginosa clinical isolate in 2012, HMB type beta-lactamases can be encoded in transposons and hydrolyze carbapenems." [PMID:28065891] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004210 name: SFH beta-lactamase namespace: antibiotic_resistance def: "This type of Subclass B2 beta-lactamases was first identified from a Serratia fonticola environmental isolate." [PMID:12821491] is_a: ARO:3000570 ! subclass B2 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004211 name: FEZ beta-lactamase namespace: antibiotic_resistance def: "The FEZ family of beta-lactamases are subclass B3 beta-lactamases that hydrolyze penicillins, cephalosporins, and carbapenems." [PMID:18563261] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004212 name: GOB beta-lactamase namespace: antibiotic_resistance def: "The GOB family of beta-lactamases have been discovered in the Elizabethkingia meningoseptica and are classified as subclass B3 beta-lactamase. They confer resistance to cephalosporins, penicillins, and carbapenems." [PMID:27458232, PMID:17403673, PMID:10858348] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004213 name: GOB-18 namespace: antibiotic_resistance def: "GOB-18 is a member of subclass B3 GOB family of beta-lactamases isolated from Elizabethkingia meningoseptica. GOB-18 is unlike other subclass B3 beta-lactamases as it is fully active against a broad range of beta-lactam substrates using a single Zn(II) ion in its active site." [PMID:17403673, PMID:27458232] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-18" EXACT CARD_Short_Name [] [Term] id: ARO:3004214 name: THIN-B beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases that are part of the THIN-B family, which is a subclass B3 beta-lactamase family and hydrolyze a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems." [PMID:11181369, PMID:15561856] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004215 name: L1 family beta-lactamase namespace: antibiotic_resistance def: "This subclass B3 of beta-lactamses have the ability to hydrolyze cephalosporins." [PMID:9811546] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004216 name: AIM beta-lactamase namespace: antibiotic_resistance def: "A subclass B3 family of beta-lactamases that confer resistance to a range of beta-lactam antibiotics including penams, cephamycins, and cephalosporins." [PMID:22664968] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004217 name: SMB beta-lactamase namespace: antibiotic_resistance def: "SMB beta-lactamases are a subclass B3 beta-lactamases that hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems." [PMID:22442240] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004218 name: CAU beta-lactamase namespace: antibiotic_resistance def: "CAU beta-lactamases are a subclass B3 family." [PMID:12019096] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004219 name: BJP beta-lactamase namespace: antibiotic_resistance def: "BJP beta-lactamases are a subclass B3 family." [PMID:16723554] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004220 name: subclass B3 PEDO beta-lactamase namespace: antibiotic_resistance def: "PEDO family enzymes that are classified under subclass B3 (metallo-) beta-lactamases." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004221 name: CPS beta-lactamase namespace: antibiotic_resistance def: "CPS beta-lactamases are a subclass B3 family." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004222 name: ESP beta-lactamase namespace: antibiotic_resistance def: "ESP family beta-lactamases are subclass B3 (metallo-) beta-lactamases." [PMID:26482314] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004223 name: MSI beta-lactamase namespace: antibiotic_resistance def: "MSI beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases." [PMID:26482314] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004224 name: SPG beta-lactamase namespace: antibiotic_resistance def: "SPG beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases." [PMID:26482314] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004225 name: Rm3 family beta-lactamase namespace: antibiotic_resistance def: "A family encompassing subclass B3 Rm3-like beta-lactamases." [PMID:27431213] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004226 name: subclass B3 LRA beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases that are part of the LRA gene family and are classified as B3 (metallo-) beta-lactamases." [PMID:18843302] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004227 name: subclass B1 PEDO beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases that are part of the PEDO gene family and are classified as subclass B1 (metallo-) beta-lactamases." [PMID:26482314] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004228 name: class A LRA beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases that are part of the LRA gene family and are classified as Class A beta-lactamases." [PMID:18843302] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004229 name: class A Bacillus anthracis Bla beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as class A beta-lactamases." [PMID:12760895] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004230 name: subclass B1 Bacillus anthracis Bla beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as subclass B1 beta-lactamases." [PMID:12760895] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004231 name: class C LRA beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases." [PMID:18843302] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004232 name: ampC-type beta-lactamase namespace: antibiotic_resistance def: "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related." [PMID:21304033] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004233 name: blaF family beta-lactamase namespace: antibiotic_resistance def: "Class A Beta-lactamases first isolated from Mycolicibacterium fortuitum." [PMID:8065266] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004234 name: EXO beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases part of this family discovered in Streptomyces albus G." [PMID:2658780] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004235 name: RCP beta-lactamase namespace: antibiotic_resistance def: "A family of class A beta-lactamases that have been discovered in the Rhodobacter genus." [PMID:2783689, PMID:2788410] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004236 name: gimA family macrolide glycosyltransferase namespace: antibiotic_resistance def: "This family of macrolide glycosyltransferases derive from gimA, which was discovered in Streptomyces ambofaciens." [PMID:9756764] is_a: ARO:3000458 ! macrolide glycosyltransferase relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic [Term] id: ARO:3004237 name: mgt macrolide glycotransferase namespace: antibiotic_resistance def: "The mgt family encompasses macrolide glycotransferases of the Streptomyces genus." [PMID:1612452, PMID:1605601] is_a: ARO:3000458 ! macrolide glycosyltransferase relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic [Term] id: ARO:3004238 name: sulfonamide resistant sul namespace: antibiotic_resistance def: "The sul genes encode forms of dihydropteroate synthase that confer resistance to sulfonamide." [PMID:15673783] is_a: ARO:3000381 ! antibiotic target replacement protein relationship: confers_resistance_to_drug_class ARO:3000282 ! sulfonamide antibiotic [Term] id: ARO:3004239 name: NPS-1 namespace: antibiotic_resistance def: "NPS-1 is a plasmid-encoded class D beta-lactamases identified from two Pseudomonas aeruginosa isolates in 1986." [PMID:11557499, PMID:3089139] is_a: ARO:3004240 ! NPS beta-lactamase synonym: "NPS-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004240 name: NPS beta-lactamase namespace: antibiotic_resistance def: "NPS beta-lactamases are class D beta-lactamases that have partial hydrolyzing abilities against penicillins and cephalosporin." [] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004241 name: class D LRA beta-lactamase namespace: antibiotic_resistance def: "Beta-lactamases that are part of the LRA gene family and are classified as Class D beta-lactamases." [PMID:18843302] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004242 name: MSI-OXA family beta-lactamase namespace: antibiotic_resistance def: "Members of the MSI-OXA family are class D beta-lactamases that encompass hybrids of MSI-1 and putative OXA homologues." [PMID:26482314] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004243 name: RbpA bacterial RNA polymerase-binding protein namespace: antibiotic_resistance def: "RbpA is a family of bacterial RNA polymerase-binding proteins, which acts as a transcription factor and binds to the sigma subunit of RNA polymerase." [PMID:22570422, PMID:16629670] is_a: ARO:3000507 ! rifampin-resistant RNA polymerase-binding protein relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic [Term] id: ARO:3004244 name: DnaA chromosomal replication initiation protein namespace: antibiotic_resistance def: "The DnaA family of replication initiation proteins interact with RNA polymerase to confer resistance against rifampicin anitibiotics." [PMID:19170875, PMID:21527473] is_a: ARO:3000507 ! rifampin-resistant RNA polymerase-binding protein relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic [Term] id: ARO:3004245 name: fosC phosphotransferase family namespace: antibiotic_resistance def: "The fosC family of phosphotransferases phosphorylate fosfomycin to confer resistance and have been found in various bacterial isolates." [PMID:7492106, PMID:20404116] is_a: ARO:3000359 ! fosfomycin phosphotransferase relationship: confers_resistance_to_drug_class ARO:3007149 ! phosphonic acid antibiotic [Term] id: ARO:3004246 name: Fom phosphotransferase family namespace: antibiotic_resistance def: "Two members of the Fom family have been identified, FomA and FomB. FomB must interact with FomA confer resistance to fosfomycin, however FomA is capable of conferring resistance alone." [] is_a: ARO:3000359 ! fosfomycin phosphotransferase relationship: confers_resistance_to_drug_class ARO:3007149 ! phosphonic acid antibiotic [Term] id: ARO:3004247 name: antibiotic-resistant GlpT namespace: antibiotic_resistance def: "Fosfomycin is transported bacterial cells through transporters, one of them being glycerol-3-phosphate, which is encoded by the GlpT gene. Mutations in the GlpT gene can confer resistance to fosfomycin." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007149 ! phosphonic acid antibiotic [Term] id: ARO:3004248 name: antibiotic-resistant UhpT namespace: antibiotic_resistance def: "UhpT encodes a transporter that can import fosfomycin-type drugs into bacterial cells. Mutations to UhpT confer resistance." [PMID:28579984] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007149 ! phosphonic acid antibiotic [Term] id: ARO:3004249 name: UhpA namespace: antibiotic_resistance def: "UhpA acts as a positive regulator of UhpT, which is a transporter to bring fosfomycin drugs into bacterial cells. Mutations in UhpA that negatively impact the expression of UhpT can confer resistance." [PMID:19671590, PMID:20071153] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: regulates ARO:3004248 ! antibiotic-resistant UhpT [Term] id: ARO:3004250 name: antibiotic-resistant ptsI phosphotransferase namespace: antibiotic_resistance def: "PtsI family phosphotransferases are involved in cyclic AMP synthesis, which regulates glpT expression. Mutations in PtsI family genes can negatively affect expression of UhpT, which is needed for fosfomycin import." [PMID:20071153] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007149 ! phosphonic acid antibiotic [Term] id: ARO:3004251 name: antibiotic-resistant cya adenylate cyclase namespace: antibiotic_resistance def: "Adenylate cyclases encoded by cya genes, which are involved in the synthesis cyclic AMP which regulates the fosfomycin transporter glpT. Mutations in cya genes can confer resistance to fosfomycin." [PMID:14519998] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007149 ! phosphonic acid antibiotic [Term] id: ARO:3004253 name: vanU gene in vanG cluster namespace: antibiotic_resistance def: "Also known as vanUG, is a vanG variant found in the vanG gene cluster." [PMID:11036060, PMID:14617152, PMID:16723588] is_a: ARO:3000575 ! vanU relationship: part_of ARO:3000257 ! glycopeptide resistance gene cluster VanG synonym: "vanU-G" EXACT [] synonym: "vanUG" EXACT [] synonym: "vanU_in_vanG_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3004254 name: vanV gene in vanB cluster namespace: antibiotic_resistance def: "Also known as vanVB, is a vanV variant found in the vanB gene cluster. It is found in some but not all vanB operons in E. faecalis, suggesting the existence of varied gene compositions in vanB operons." [PMID:21482081] is_a: ARO:3002916 ! vanV relationship: part_of ARO:3000238 ! glycopeptide resistance gene cluster VanB synonym: "vanV-B" EXACT [] synonym: "vanVB" EXACT [] synonym: "vanV_in_vanB_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3004255 name: vanJ membrane protein namespace: antibiotic_resistance def: "vanJ and vanJ homologue proteins confer resistance to teicoplanin." [PMID:22232274] is_a: ARO:3002976 ! gene(s) or protein(s) associated with a glycopeptide resistance cluster relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3004256 name: Bleomycin resistant protein namespace: antibiotic_resistance def: "Bleomycin resistant proteins (BRP) confer resistance to bleomycin and to bleomycin-like molecules." [PMID:22290943, PMID:18791008] is_a: ARO:3001207 ! gene involved in antibiotic sequestration relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3004257 name: cpa acetyltransferase namespace: antibiotic_resistance def: "Acetyltransferases of the cpa family confer resistance to capreomycin, an aminoglycoside antibiotic." [PMID:27929110] is_a: ARO:3000121 ! aminoglycoside acetyltransferase (AAC) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004260 name: Bah amidohydrolase namespace: antibiotic_resistance def: "Bah amidohydrolases are membrane proteins that inactivate bacitracin." [PMID:27929110] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004261 name: viomycin phosphotransferase namespace: antibiotic_resistance def: "Viomycin family of phosphotransferases confer resistance to viomycin antibiotics." [PMID:2987648] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: participates_in ARO:3000105 ! phosphorylation of antibiotic conferring resistance [Term] id: ARO:3004262 name: daptomycin resistant liaF namespace: antibiotic_resistance def: "Mutations to the liaF accessory protein that confer resistance to daptomycin." [PMID:21899450] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: part_of ARO:3003076 ! daptomycin resistant liaFSR [Term] id: ARO:3004263 name: daptomycin resistant liaR namespace: antibiotic_resistance def: "Mutations to the liaR response regulator that confer resistance to daptomycin." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: part_of ARO:3003076 ! daptomycin resistant liaFSR [Term] id: ARO:3004264 name: daptomycin resistant liaS namespace: antibiotic_resistance def: "Mutations in the liaS histidine kinase that confer daptomycin resistance." [PMID:21899450] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: part_of ARO:3003076 ! daptomycin resistant liaFSR [Term] id: ARO:3004265 name: lysocin resistant menA namespace: antibiotic_resistance def: "Mutations to demA confer lycosin resistance." [PMID:25485686] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004266 name: antibiotic resistant katG namespace: antibiotic_resistance def: "Point mutations in katG confer antibiotic resistance by preventing katG from catalyzing the activation of antibiotics." [PMID:23744165] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004267 name: antibiotic resistant pncA namespace: antibiotic_resistance def: "Point mutations in pncA prevent the enzyme from activating antibiotics, such as pyrazinamide." [PMID:9055989] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004268 name: MCR phosphoethanolamine transferase namespace: antibiotic_resistance def: "A group of mobile colistin resistance genes encode the MCR family of phosphoethanolamine transferases, which catalyze the addition of phosphoethanolamine onto lipid A, thus interfering with the binding of colistin to the cell membrane." [PMID:26603172, PMID:28487432, PMID:28655818, PMID:27401575] is_a: ARO:3004112 ! phosphoethanolamine transferase conferring colistin resistance relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004269 name: pmr phosphoethanolamine transferase namespace: antibiotic_resistance def: "This family of phosphoethanolamine transferase catalyze the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine to lipid A, which impedes the binding of colistin to the cell membrane." [PMID:15205413, PMID:9570402] is_a: ARO:3004112 ! phosphoethanolamine transferase conferring colistin resistance relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004270 name: antibiotic resistant fabI namespace: antibiotic_resistance def: "fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid." [PMID:27577999] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic relationship: derives_from ARO:3004044 ! antibiotic sensitive fabI [Term] id: ARO:3004271 name: 16S rRNA methyltransferase (G1405) namespace: antibiotic_resistance def: "Methyltransferases that methylate the G1405 position of 16S rRNA, which is part of an aminoglycoside binding site." [PMID:21177880] is_a: ARO:3000857 ! 16S ribosomal RNA methyltransferase relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004272 name: 16S rRNA methyltransferase (A1408) namespace: antibiotic_resistance def: "Methyltransferases that methylate the A1408 position of 16S rRNA, which is part of an aminoglycoside binding site." [PMID:19589804, PMID:17875999] is_a: ARO:3000857 ! 16S ribosomal RNA methyltransferase relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004273 name: Llm 23S ribosomal RNA methyltransferase namespace: antibiotic_resistance def: "A family of lincosamide resistant 23S rRNA methyltransferases. The only member of the family discovered so far was isolated from Paenibacillus sp. LC231, a strain found in Lechuguilla Cave, NM, USA." [PMID:27929110] is_a: ARO:3004274 ! 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic [Term] id: ARO:3004274 name: 23S ribosomal RNA methyltransferase namespace: antibiotic_resistance def: "Methyltransferases that modify the 23S rRNA of the 50S subunit of bacterial ribosomes, conferring resistance to drugs that target 23S rRNA." [PMID:20144045, PMID:20618865, PMID:7590303] is_a: ARO:3000164 ! rRNA methyltransferase conferring antibiotic resistance [Term] id: ARO:3004275 name: ANT(3'') namespace: antibiotic_resistance def: "A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound." [PMID:20833577] is_a: ARO:3000218 ! aminoglycoside nucleotidyltransferase (ANT) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004276 name: ANT(2'') namespace: antibiotic_resistance def: "A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 2''-hydroxyl group of the compound." [PMID:25564464] is_a: ARO:3000218 ! aminoglycoside nucleotidyltransferase (ANT) relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004277 name: General Bacterial Porin (GBP) namespace: antibiotic_resistance def: "General bacterial porins are a family of porins found in the outer membrane of Gram-negative bacteria. They catalyze the energy-independent transport of small molecules across the outer membranes of bacteria. Most of the porins of these family are homotrimeric and have variable selectivity, ranging from being cation-selective, anion-selective or selective for different compounds. The most well characterized members of this family are the OmpF and OmpC porins of Escherichia coli. This family is also known as the classical porins." [PMID:18997824] is_a: ARO:3000270 ! protein modulating permeability to antibiotic [Term] id: ARO:3004278 name: Outer Membrane Porin (Opr) namespace: antibiotic_resistance def: "The Opr family consists of porins in Pseudomonas species, and other Gram-negative bacteria, that exhibit a variety of substrate selectivities." [PMID:18997824] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3004279 name: Sugar Porin (SP) namespace: antibiotic_resistance def: "Members of the Sugar Porin family tend to facilitate the transport of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. These porins form a homotrimeric structure." [] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:3000050 ! tetracycline antibiotic [Term] id: ARO:3004280 name: MipA-interacting Protein namespace: antibiotic_resistance def: "The MltA-interacting Protein (MipA) family consists mainly of homologs to MipA and OmpV proteins. Proteins of this family, are predicted to form a beta-barrel." [] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004281 name: General Bacterial Porin with reduced permeability to beta-lactams namespace: antibiotic_resistance def: "These are GBPs that are associated with decreased susceptibility to beta-lactams either through mutations in the porin protein, absence of the porin protein, or expression of the porin protein." [] is_a: ARO:3004277 ! General Bacterial Porin (GBP) relationship: confers_resistance_to_drug_class ARO:0000004 ! monobactam relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3004282 name: General Bacterial Porin with reduced permeability to peptide antibiotics namespace: antibiotic_resistance def: "These are GBPs that are associated with decreased susceptibility to peptide antibiotics either through mutations in the porin protein, absence of the porin protein, or expression of the porin protein." [] is_a: ARO:3004277 ! General Bacterial Porin (GBP) relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004283 name: CarO porin namespace: antibiotic_resistance def: "The imipenum resistance-associated CarO porin family is composed of the CarO porin originally identified in Acinetobacter baumannii. The loss of these porins is associated with imipenem and meropenem multi-drug resistance. The channels formed by CarO porins show slight cation selectivity." [] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004284 name: antibiotic resistant fabG namespace: antibiotic_resistance def: "fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics relationship: derives_from ARO:3004050 ! antibiotic sensitive fabG [Term] id: ARO:3004285 name: tunicamycin resistance protein namespace: antibiotic_resistance def: "A grouping of tunicamycin resistance proteins that are homologous to tmrB found in Bacillus subtilis." [PMID:1624425] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_antibiotic ARO:0000009 ! tunicamycin relationship: confers_resistance_to_drug_class ARO:3000034 ! nucleoside antibiotic [Term] id: ARO:3004286 name: phenotypic variant regulator namespace: antibiotic_resistance def: "Phenotypic variant regulator proteins play a role in controlling the switch between antibiotic-susceptible and antibiotic-resistant forms of bacteria. The characterized member of this family is the PvrR protein in Pseudomonas aeruginosa, which when absent, confers antibiotic resistance." [PMID:22195037] is_a: ARO:3003768 ! gene conferring resistance via absence relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004287 name: lipid A phosphatase namespace: antibiotic_resistance def: "The antimicrobial activity of certain antibiotics, such as peptide antibiotics, is proposed to be initiated through binding to the lipid A moiety of lipopolysaccharides. Thus, covalent modification of Gram-negative bacterial lipid A by phosphatases is a mechanism to reduce the susceptibility of the bacteria to antibiotics." [] is_a: ARO:3003580 ! gene altering cell wall charge relationship: confers_resistance_to_antibiotic ARO:3000625 ! polymyxin B1 relationship: confers_resistance_to_antibiotic ARO:3000626 ! polymyxin B2 relationship: confers_resistance_to_antibiotic ARO:3000627 ! polymyxin B3 relationship: confers_resistance_to_antibiotic ARO:3000628 ! polymyxin B4 relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004288 name: Subclass B1 Vibrio cholerae varG beta-lactamase namespace: antibiotic_resistance def: "varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro." [PMID:28898293] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004289 name: Vibrio cholerae varG namespace: antibiotic_resistance def: "varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. Described by Lin HV et al. 2017." [PMID:28898293] is_a: ARO:3004288 ! Subclass B1 Vibrio cholerae varG beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem synonym: "Vcho_varG" EXACT CARD_Short_Name [] [Term] id: ARO:3004290 name: Escherichia coli ampC beta-lactamase namespace: antibiotic_resistance def: "A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics." [PMID:3055168, PMID:19136439] is_a: ARO:3004232 ! ampC-type beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000054 ! penicillin synonym: "Ecol_ampC_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3004291 name: Rhodobacter sphaeroides ampC beta-lactamase namespace: antibiotic_resistance def: "A periplasmic cephalosporinase described in Rhodobacter sphaeroides shown to contribute to resistance of beta-lactam antibiotics." [PMID:2783689] is_a: ARO:3004232 ! ampC-type beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin synonym: "Rsph_ampC_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3004292 name: Laribacter hongkongensis ampC beta-lactamase namespace: antibiotic_resistance def: "A chromosome-encoded class C beta-lactamase described in the pathogen Laribacter hongkongensis, often associated with gastroenteritis. Laribacter ampC has been shown to confer resistance to non-carbapenem beta-lactamases, as described by Lau et al. 2005." [PMID:15855519] is_a: ARO:3004232 ! ampC-type beta-lactamase synonym: "Lhon_ampC_BLA" EXACT CARD_Short_Name [] synonym: "blaLHK-5" EXACT [] [Term] id: ARO:3004293 name: BUT beta-lactamase namespace: antibiotic_resistance def: "A class C beta-lactamase family of chromosome-encoded antibiotic resistance genes originally described from Buttiauxella spp." [PMID:12127496] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004294 name: BUT-1 namespace: antibiotic_resistance def: "A chromosome-encoded class C cephalosporinase and penicillinase from Buttiauxella spp. shown clinically to confer resistance to beta-lactam antibiotics. Described by Fihman et al. 2002." [PMID:12127496] is_a: ARO:3004293 ! BUT beta-lactamase synonym: "BUT-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004295 name: lassomycin namespace: antibiotic_resistance def: "A ribosomally synthesized cyclic peptide antibiotic. Lassomycin has been shown to be effective against drug-resistant mycobacteria but shows little activity against other bacteria. Lassomycin targets and binds to a region of the ClpC1 ATPase complex and uncouples ATPase from proteolytic activity, an essential function for mycobacterial viability, causing cell death." [PMID:24684906] is_a: ARO:3000157 ! rifamycin antibiotic xref: pubchem.compound:132528125 [Term] id: ARO:3004296 name: bulgecin A namespace: antibiotic_resistance def: "Bulgecin A is a lytic transglycosylase inhibitor and antibiotic potentiator produced from Pseudomonas mesoacidophila. In the presence of some beta-lactam antibiotics, including ampicillin and meropenem, bulgecin A has been shown to restore susceptibility to carbapenems in carbapenem-resistant pathogens." [PMID:27703329] is_a: ARO:3004564 ! unclassified resistance-modifying agents xref: pubchem.compound:444940 [Term] id: ARO:3004299 name: antimicrobial phenotype namespace: antibiotic_resistance def: "Qualitative description of a microbial response to antimicrobial agents and the expected clinical outcome. Bacteria may be susceptible or resistant to a broad range of antibiotic drugs or drug classes, with several intermediate states or phases." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: ARO:3004300 name: intermediate antimicrobial phenotype namespace: antibiotic_resistance def: "Intermediate sensitivity of a bacterial strain to a given antibiotic occurs when it is inhibited by a concentration of the drug that is associated with uncertain therapeutic effect. The elimination of intermediate phenotype bacteria may depend on the site of infection and/or the concentration of the administered drug. Definition from https://clsi.org." [] is_a: ARO:3004440 ! CLSI antimicrobial phenotype [Term] id: ARO:3004301 name: resistant antimicrobial phenotype namespace: antibiotic_resistance def: "A bacterial strain is said to be resistant to a given antibiotic when it is inhibited in vitro by a concentration of this drug that is associated with a high likelihood of therapeutic failure." [PMID:19626213] is_a: ARO:3004440 ! CLSI antimicrobial phenotype [Term] id: ARO:3004302 name: susceptible antimicrobial phenotype namespace: antibiotic_resistance def: "A bacterial strain is said to be susceptible to a given antibiotic when it is inhibited in vitro by a concentration of a drug that is associated with a high likelihood of therapeutic success." [PMID:19626213] is_a: ARO:3004440 ! CLSI antimicrobial phenotype [Term] id: ARO:3004303 name: nonsusceptible antimicrobial phenotype namespace: antibiotic_resistance def: "A bacterial strain is said to be nonsusceptible to a given antibiotic drug if it demonstrates either an intermediate or resistant phenotype when exposed to a concentration of a drug that is associated with a high likelihood of therapeutic failure, i.e. if the bacterial strain is not susceptible to the antibiotic drug but not necessarily totally resistant under all conditions. Definition from https://clsi.org." [] is_a: ARO:3004440 ! CLSI antimicrobial phenotype synonym: "nonsensitive antimicrobial phenotype" EXACT [] [Term] id: ARO:3004304 name: susceptible dose dependent antimicrobial phenotype namespace: antibiotic_resistance def: "A bacterial strain is said to be susceptible-dose dependent (SDD) to a given antibiotic when growth is inhibited with a high likelihood of therapeutic success, but when multiple approved dosing options exist. When a higher or more frequent dose is used, the predicted therapeutic result is the same as for susceptible individuals." [] is_a: ARO:3004440 ! CLSI antimicrobial phenotype synonym: "SDD" EXACT [] synonym: "Sensitive dose dependent antimicrobial phenotype" EXACT [] [Term] id: ARO:3004305 name: multidrug resistance antimicrobial phenotype namespace: antibiotic_resistance def: "Multidrug-resistant organisms are defined as bacterial strains that have become resistant to multiple classes of antibacterial drugs or other agents. The phenotype of these organisms is defined by the spectrum of antibiotic drug classes to which that organism is resistant. Often, these organisms are susceptible to a narrow range of available drugs, making treatment difficult and urgent." [PMID:19626213] is_a: ARO:3004299 ! antimicrobial phenotype synonym: "MDRO" EXACT [] [Term] id: ARO:3004306 name: methicillin-resistant Staphylococcus aureus namespace: antibiotic_resistance def: "Any strain of Staphylococcus aureus that has tested resistant (R) to at least one of methicillin, oxacillin or cefoxitin by standard susceptibility testing methods." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype synonym: "MRSA" EXACT [] [Term] id: ARO:3004307 name: Linezolid-resistant MRSA namespace: antibiotic_resistance def: "Methicillin-resistant Staphylococcus aureus that has additionally tested resistant to the antibiotic drug linezolid." [] is_a: ARO:3004306 ! methicillin-resistant Staphylococcus aureus [Term] id: ARO:3004308 name: Fluoroquinolone-resistant MRSA namespace: antibiotic_resistance def: "Methicillin-resistant Staphylococcus aureus that has additionally tested resistant to the fluoroquinolone antibiotics ciprofloxacin and/or levofloxacin." [] is_a: ARO:3004306 ! methicillin-resistant Staphylococcus aureus [Term] id: ARO:3004309 name: Vancomycin-intermediate MRSA namespace: antibiotic_resistance def: "Methicillin-resistant Staphylococcus aureus that has additionally tested intermediate to vancomycin antibiotics." [] is_a: ARO:3004306 ! methicillin-resistant Staphylococcus aureus [Term] id: ARO:3004310 name: Daptomycin-resistant MRSA namespace: antibiotic_resistance def: "Methicillin-resistant Staphylococcus aureus that has additionally tested non-susceptible (NS, resistant or intermediate) to daptomycin antibiotics." [] is_a: ARO:3004306 ! methicillin-resistant Staphylococcus aureus [Term] id: ARO:3004311 name: carbapenem-resistant Acinetobacter namespace: antibiotic_resistance def: "Any strain of Acinetobacter spp. that has tested either Intermediate or Resistant to at least one of the following carbapenem-class antibiotics by standard testing using approved breakpoints: imipenem, meropenem, doripenem." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004312 name: multidrug-resistant Acinetobacter namespace: antibiotic_resistance def: "Any strain of an Acinetobacter spp. that has either tested Intermediate or Resistant to at least one antibiotic drug in at least 3 of the 6 following categories: 1) Extended-spectrum cephalosporins, 2) Fluoroquinolone, 3) Aminoglycosides, 4) Carbapenems, 5) Piperacillin group, and 6) Ampicillin/sulbactam." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004313 name: carbapenem-resistant Escherichia coli namespace: antibiotic_resistance def: "Any strain of E. coli that has tested resistant to one of the following carbapenem antibiotics: imipenem, meropenem, doripenem, ertapenem." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004314 name: extended-spectrum cephalosporin-resistant Escherichia coli namespace: antibiotic_resistance def: "Any E.coli that has tested resistant (R) to at least one of the following: ceftriaxone, ceftazidime, cefepime, and cefotaxime." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004315 name: fluoroquinolone-resistant Escherichia coli namespace: antibiotic_resistance def: "Any E.coli that has tested resistant (R) to at least one of the following: ciprofloxacin, levofloxacin, and moxifloxacin." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004316 name: multidrug-resistant Escherichia coli namespace: antibiotic_resistance def: "Any E.coli that has tested either intermediate (I) or resistant (R) to at least one drug in at least 3 of the following 5 categories: 1) Extended-spectrum cephalosporins, 2) Fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin), 3) Aminoglycosides (amikacin, gentamicin, tobramycin), 4) Carbapenems (imipenem, meropenem, doripenem, ertapenem), 5) Piperacillin Group (piperacillin, piperacillin/tazobactam)." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004317 name: carbapenem-resistant Enterobacter namespace: antibiotic_resistance def: "Any Enterobacter spp. that has tested resistant to at least one of the following antibiotic drugs: imipenem, meropenem, doripenem, ertapenem." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004318 name: extended-spectrum cephalosporin-resistant Enterobacter namespace: antibiotic_resistance def: "Any Enterobacter spp. that has tested resistant to at least one of the following antibiotics: ceftriaxone, ceftazidime, cefepime, and/or cefotaxime." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004319 name: multidrug-resistant Enterobacter namespace: antibiotic_resistance def: "Any Enterobacter spp. that has tested either Intermediate or Resistant to at least one drug in at least 3 of the following categories: extended-spectrum cephalosporins, fluoroquinolones, aminoglycosides, carbapenems, and/or pipericillin/tazobactam." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004320 name: carbapenem-resistant Klebsiella namespace: antibiotic_resistance def: "Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested resistant to at least one of the following antibiotics: imipenem, meropenem, doripenem, ertapenem." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004321 name: extended-spectrum cephalosporin-resistant Klebsiella namespace: antibiotic_resistance def: "Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested resistant to at least one of the following antibiotics: ceftriaxone, ceftazidime, cefepime, and/or cefotaxime." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004322 name: multidrug-resistant Klebsiella namespace: antibiotic_resistance def: "Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested Intermediate or Resistant in at least 3 of the following categories: extended-spectrum cephalosporins, fluoroquinolones, aminoglycosides, carbapenems, or pipericillin/tazobactam." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004323 name: carbapenem-resistant Pseudomonas aeruginosa namespace: antibiotic_resistance def: "Any strain of Pseudomonas aeruginosa that has tested either Intermediate or Resistant to at least one of the following antibiotics: imipenem, meropenem and/or doripenem." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004324 name: extended-spectrum cephalosporin-resistant Pseudomonas aeruginosa namespace: antibiotic_resistance def: "Any strain of Pseudomonas aeruginosa that has tested Resistant to at least one of the following antibiotics: cefepime and/or ceftazidime." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004325 name: MCR-4.1 namespace: antibiotic_resistance def: "MCR-4 is a plasmid-borne phosphoethanolamine transferase variant of MCR-1, isolated from Salmonella enterica serovar Typhimurium of porcine origin in Italy, Spain and Belgium through 2013 and 2015-2016. MCR-4 confers resistance to collistin via addition of a phosphoethanolamine group to lipid A, reducing the negative charge of the cell membrane. Described by Carattoli et al. 2017." [PMID:28797329] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-4" EXACT [] synonym: "MCR-4.1" EXACT CARD_Short_Name [] [Term] id: ARO:3004326 name: fluoroquinolone-resistant Pseudomonas aeruginosa namespace: antibiotic_resistance def: "Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: ciprofloxacin, levofloxacin." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004327 name: aminoglycoside-resistant Pseudomonas aeruginosa namespace: antibiotic_resistance def: "Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: amikacin, gentamicin, tobramycin." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004328 name: pipericillin-resistant Pseudomonas aeruginosa namespace: antibiotic_resistance def: "Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: piperacillin, piperacillin/tazobactam." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004329 name: vancomycin-resistant Enterococcus namespace: antibiotic_resistance def: "Any Enterococcus faecium or Enterococcus faecalis that has tested resistant (R) to vancomycin." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype synonym: "VRE" EXACT [] [Term] id: ARO:3004330 name: daptomycin-resistant Enterococcus namespace: antibiotic_resistance def: "Any Enterococcus faecium or Enterococcus faecalis that has tested non-susceptible (NS) to daptomycin." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004331 name: vancomycin-resistant coagulase-negative Staphylococci namespace: antibiotic_resistance def: "Coagulase-Negative Staphylococci that has tested resistant(R) or intermediate(I) to vancomycin." [] is_a: ARO:3004305 ! multidrug resistance antimicrobial phenotype [Term] id: ARO:3004332 name: MCR-5.1 namespace: antibiotic_resistance def: "MCR-5 is a transposon-associated phosphoethanolamine transferase gene, identified in Salmonella Paratyphi B dTa+ (d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B) isolates from food-producing animals. The isolates were collected between 2011 and 2013, and retrieved from the German National Reference Laboratory for Salmonella. MCR-5 confers resistance to collistin through the addition of a phosphoethanolamine group to lipid A, causing a reduction in negative charge of the cell membrane. Described by Borowiak et al, 2017." [PMID:30053115, PMID:28962028] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-5.1" EXACT CARD_Short_Name [] [Term] id: ARO:3004333 name: triclosan resistant gyrA namespace: antibiotic_resistance def: "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA." [PMID:29091182] is_a: ARO:3000273 ! antibiotic resistant DNA topoisomerase subunit gyrA relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics [Term] id: ARO:3004334 name: Salmonella enterica gyrA with mutation conferring resistance to triclosan namespace: antibiotic_resistance def: "Point mutations in Salmonella enterica serovar Typhimurium which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in Salmonella gyrA mutants occurs indirectly due to alterations in the stress response pathways." [PMID:29091182] is_a: ARO:3004333 ! triclosan resistant gyrA relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan synonym: "Sent_gyrA_TRC" EXACT CARD_Short_Name [] [Term] id: ARO:3004335 name: Escherichia coli gyrA with mutation conferring resistance to triclosan namespace: antibiotic_resistance def: "Point mutations in Escherichia coli which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in E. coli gyrA mutants occurs indirectly due to alterations in the stress response pathways." [PMID:29091182] is_a: ARO:3004333 ! triclosan resistant gyrA relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan synonym: "Ecol_gyrA_TRC" EXACT CARD_Short_Name [] [Term] id: ARO:3004336 name: PDC-73 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-73" EXACT CARD_Short_Name [] [Term] id: ARO:3004337 name: PDC-74 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-74" EXACT CARD_Short_Name [] [Term] id: ARO:3004338 name: PDC-75 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-75" EXACT CARD_Short_Name [] [Term] id: ARO:3004339 name: PDC-76 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-76" EXACT CARD_Short_Name [] [Term] id: ARO:3004340 name: PDC-77 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-77" EXACT CARD_Short_Name [] [Term] id: ARO:3004341 name: PDC-78 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-78" EXACT CARD_Short_Name [] [Term] id: ARO:3004342 name: PDC-79 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-79" EXACT CARD_Short_Name [] [Term] id: ARO:3004343 name: PDC-80 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-80" EXACT CARD_Short_Name [] [Term] id: ARO:3004344 name: PDC-81 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-81" EXACT CARD_Short_Name [] [Term] id: ARO:3004345 name: PDC-82 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-82" EXACT CARD_Short_Name [] [Term] id: ARO:3004346 name: PDC-83 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-83" EXACT CARD_Short_Name [] [Term] id: ARO:3004347 name: PDC-84 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-84" EXACT CARD_Short_Name [] [Term] id: ARO:3004348 name: PDC-85 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-85" EXACT CARD_Short_Name [] [Term] id: ARO:3004349 name: PDC-86 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-86" EXACT CARD_Short_Name [] [Term] id: ARO:3004350 name: PDC-87 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-87" EXACT CARD_Short_Name [] [Term] id: ARO:3004351 name: PDC-88 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-88" EXACT CARD_Short_Name [] [Term] id: ARO:3004352 name: PDC-89 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-89" EXACT CARD_Short_Name [] [Term] id: ARO:3004353 name: PDC-90 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-90" EXACT CARD_Short_Name [] [Term] id: ARO:3004354 name: PDC-91 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-91" EXACT CARD_Short_Name [] [Term] id: ARO:3004355 name: PDC-92 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-92" EXACT CARD_Short_Name [] [Term] id: ARO:3004356 name: PDC-93 namespace: antibiotic_resistance def: "An AmpC-like beta-lactamase found in Pseudomonas aeruginosa." [PMID:26248364] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-93" EXACT CARD_Short_Name [] [Term] id: ARO:3004357 name: catV namespace: antibiotic_resistance def: "A chloramphenicol acetyltransferase identified in Brevibacillus brevis and shown to confer resistance to chloramphenicol antibiotics. Described by Pawlowski et al. 2017." [PMID:29259290] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "catV" EXACT CARD_Short_Name [] [Term] id: ARO:3004358 name: ACI beta-lactamase namespace: antibiotic_resistance def: "A family of class A beta-lactamase enzymes described in the gram-negative cocci Acidaminococcus fermentans." [PMID:11036038] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004359 name: ACI-1 namespace: antibiotic_resistance def: "A class A beta-lactamase described in Acidaminococcus fermentans. ACI-1 was the first description of a beta-lactamase enzyme in a gram-negative anaerobic cocci. Described by Galan et al 2000." [PMID:30014616, PMID:11036038] is_a: ARO:3004358 ! ACI beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000054 ! penicillin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "ACI-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004360 name: antimicrobial resistance testing reference standard namespace: antibiotic_resistance def: "Uses breakpoints to create standards for interpreting the clinical outcome of an MIC value for a particular microbial species and antimicrobial agent." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: ARO:3004361 name: sul4 namespace: antibiotic_resistance def: "sul4 is a dihydropteroate synthase gene and mobile sulfonamide resistance gene shown to confer resistance when expressed in E. coli." [PMID:29246178] is_a: ARO:3004238 ! sulfonamide resistant sul relationship: confers_resistance_to_antibiotic ARO:3000329 ! sulfamethoxazole synonym: "sul4" EXACT CARD_Short_Name [] [Term] id: ARO:3004362 name: OXA-535 namespace: antibiotic_resistance def: "A chromosome-carried OXA-48-like beta-lactamase, OXA-535, identified in Shewanella spp. JAB-1. Likely the progenitor to the plasmid-carried OXA-436. Expression of OXA-535 in E. coli demonstrated carbapenem-hydrolyzing activity. Described by Jousset et al. 2017." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-535" EXACT CARD_Short_Name [] [Term] id: ARO:3004363 name: lipid A acyltransferase namespace: antibiotic_resistance def: "Lipid A acyltransferase genes confer resistance to certain types of peptide antibiotics such as polymyxins through the aminoacylation of lipopolysaccharide, thereby decreasing the negative charge of the outer membrane surface." [PMID:29101229] is_a: ARO:3003580 ! gene altering cell wall charge is_a: ARO:3007429 ! gene(s) or protein(s) associated with polymyxin resistance operon relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004364 name: almG namespace: antibiotic_resistance def: "A member of the AlmEFG operon, responsible for polymyxin resistance in Vibrio cholerae. AlmG is a glycyltransferase closely related to lipid A acyltransferases. Described by Henderson JC et al. 2017." [PMID:29101229] is_a: ARO:3004363 ! lipid A acyltransferase relationship: part_of ARO:3007434 ! almEFG synonym: "almG" EXACT CARD_Short_Name [] [Term] id: ARO:3004365 name: British Society for Antimicrobial Chemotherapy (BSAC) namespace: antibiotic_resistance def: "BSAC is a British inter-professional organisation involved in antibiotic education, research and leadership. Baquero F. found that the BSAC system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG)." [PMID:2226478] is_a: ARO:3004360 ! antimicrobial resistance testing reference standard [Term] id: ARO:3004366 name: Clinical and Laboratory Standards Institute (CLSI) namespace: antibiotic_resistance def: "The Clinical and Laboratory Standards Institute develops and implements clinical laboratory testing standards." [] is_a: ARO:3004360 ! antimicrobial resistance testing reference standard [Term] id: ARO:3004367 name: Deutsches Institut für Normung (DIN) namespace: antibiotic_resistance def: "DIN is recognized by the Federal Government of Germany as the competent standards organization for Germany and as the national standards body representing Germany in non-governmental international standards organizations. Baquero F. found that the DIN system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG)." [PMID:2226478] is_a: ARO:3004360 ! antimicrobial resistance testing reference standard [Term] id: ARO:3004368 name: European Committee on Antimicrobial Susceptibility Testing (EUCAST) namespace: antibiotic_resistance def: "EUCAST is a standing committee jointly organized by ESCMID, ECDC and European national breakpoint committees; it deals with breakpoints and technical aspects of phenotypic in-vitro antimicrobial susceptibility testing." [] is_a: ARO:3004360 ! antimicrobial resistance testing reference standard [Term] id: ARO:3004369 name: Société Française de Microbiologie (SFM) namespace: antibiotic_resistance def: "The French Society of Microbiology (SFM) is a non-profit association which aims to bring together microbiologists from French-speaking countries, working in the domains of bacteria, viruses, Fungi and parasites, and related medical, industrial and environmental microbiology, physiology, genetics, taxonomy, hygiene, and antimicrobial agents. Baquero F. found that the SFM system recommends higher breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG)." [PMID:2226478] is_a: ARO:3004360 ! antimicrobial resistance testing reference standard [Term] id: ARO:3004370 name: minimum inhibitory concentration (MIC) namespace: antibiotic_resistance def: "Minimum inhibitory concentration (MIC), in microbiology, is the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation." [PMID:19626213] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: ARO:3004371 name: MIC value namespace: antibiotic_resistance def: "The measured or quantified MIC." [PMID:19626213] is_a: ARO:3004439 ! component of AMR phenotype measurement relationship: part_of ARO:3004370 ! minimum inhibitory concentration (MIC) [Term] id: ARO:3004372 name: MIC unit namespace: antibiotic_resistance def: "Unit for measurement of minimum inhibitory concentration (MIC)." [PMID:19626213] is_a: ARO:3004439 ! component of AMR phenotype measurement relationship: part_of ARO:3004370 ! minimum inhibitory concentration (MIC) [Term] id: ARO:3004374 name: malacidin A namespace: antibiotic_resistance def: "A calcium-dependent cyclic lipopeptide found to be effective against multidrug-resistant Staphylococcus aureus in cutaneous wound infections." [PMID:29434326] is_a: ARO:3000035 ! lipopeptide antibiotic xref: pubchem.compound:132274667 [Term] id: ARO:3004375 name: malacidin biosynthesis namespace: antibiotic_resistance def: "Biosynthesis of malacidin A and malacidin B calcium-dependent cyclic lipopeptide antibiotics from uncultured soil bacteria." [PMID:29434326] is_a: ARO:3000082 ! antibiotic biosynthesis [Term] id: ARO:3004376 name: bicyclomycin biosynthesis namespace: antibiotic_resistance def: "Biosynthesis of the broad-spectrum Rho transcription factor inhibitor bicyclomycin by hydroxylation of a tRNA-dependent cyclodipeptide synthase core." [PMID:29053243] is_a: ARO:3000082 ! antibiotic biosynthesis [Term] id: NCIT:85540 name: microbial susceptibility test namespace: antibiotic_resistance def: "A method to determine whether microbial growth is affected by an antimicrobial compound." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: ARO:3004378 name: QepA3 namespace: antibiotic_resistance def: "A plasmid-mediate quinolone efflux pump described in Klebsiella aerogenes and Escherichia coli. QepA3 confers resistance to fluoroquinolone antibiotics by expelling the antibiotic molecules from the cell. This is distinct from the usual chromosomal mutation mechanism of quinolone resistance. Described by Wang et al. 2017." [PMID:26947590] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "QepA3" EXACT CARD_Short_Name [] [Term] id: ARO:3004379 name: QepA4 namespace: antibiotic_resistance def: "A plasmid-mediated quinolone efflux pump variant described in Escherichia coli. QepA4 confers resistance to quinolone and fluoroquinolone antibiotics by expulsion from the cell. Described by Manageiro et al. 2017." [PMID:29062302] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "QepA4" EXACT CARD_Short_Name [] [Term] id: ARO:3004380 name: vaborbactam namespace: antibiotic_resistance def: "Antibiotic adjuvant and serine beta-lactamase inhibitor, often paired with meropenem for clinical use." [PMID:29232103] is_a: ARO:3007131 ! boronic acid beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3001064 ! SHV-5 relationship: is_small_molecule_inhibitor ARO:3001076 ! SHV-18 relationship: is_small_molecule_inhibitor ARO:3001866 ! CTX-M-3 relationship: is_small_molecule_inhibitor ARO:3001877 ! CTX-M-14 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3002013 ! CMY-2 relationship: is_small_molecule_inhibitor ARO:3002132 ! DHA-1 relationship: is_small_molecule_inhibitor ARO:3002166 ! MIR-1 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 relationship: is_small_molecule_inhibitor ARO:3002313 ! KPC-3 relationship: is_small_molecule_inhibitor ARO:3002380 ! SME-2 relationship: is_small_molecule_inhibitor ARO:3003589 ! NmcA xref: pubchem.compound:56649692 [Term] id: ARO:3004387 name: in-vivo microbial susceptibility test namespace: antibiotic_resistance def: "An experimental test conducted inside of a living organism, none of which currently exist for antimicrobial resistance testing." [] is_a: NCIT:85540 ! microbial susceptibility test [Term] id: ARO:3004388 name: in-vitro microbial susceptibility test namespace: antibiotic_resistance def: "An experimental test conducted outside of a living organism, usually in a tube or plate." [] is_a: NCIT:85540 ! microbial susceptibility test [Term] id: ARO:3004389 name: reagent or protocol used for testing AMR namespace: antibiotic_resistance def: "Reagents and procedures used during microbial susceptibility testing." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology relationship: part_of NCIT:85540 ! microbial susceptibility test [Term] id: ARO:3004390 name: antimicrobial resistance test platform namespace: antibiotic_resistance def: "System of analysis for determining antimicrobial susceptibility." [] is_a: NCIT:85540 ! microbial susceptibility test [Term] id: ARO:3004391 name: diffusion method namespace: antibiotic_resistance def: "Microbial species are inoculated in a growth medium onto which antimicrobial agents are transferred by diffusion." [PMID:29403965] is_a: ARO:3004388 ! in-vitro microbial susceptibility test [Term] id: ARO:3004392 name: thin-layer chromatography (TLC)-bioautography namespace: antibiotic_resistance def: "Components of complex mixtures such as plant extracts are separated across a TLC plate and tested for anti-microbial activity." [PMID:29403965] is_a: ARO:3004388 ! in-vitro microbial susceptibility test [Term] id: ARO:3004393 name: time-kill test namespace: antibiotic_resistance def: "Allows for time-dependent or concentration-dependent analysis of antimicrobial effects. Several tubes of broth culture medium containing a suspension of the test microbe are treated with varying concentrations of the antimicrobial agent and the percentage of dead cells determined at various time points." [PMID:29403965] is_a: ARO:3004388 ! in-vitro microbial susceptibility test synonym: "time kill curve" EXACT [] [Term] id: ARO:3004394 name: ATP bioluminescence assay namespace: antibiotic_resistance def: "Relies on the indirect measurement of microbe populations by quantifying microbial ATP production." [PMID:29403965] is_a: ARO:3004388 ! in-vitro microbial susceptibility test [Term] id: ARO:3004395 name: flow cytofluorometric method namespace: antibiotic_resistance def: "Microbes exposed to antimicrobial agents are then stained with the intercalating agent propidium iodide. Damaged cells emit a positive signal that is detected by flow cytometry analysis. Flow cytometry can also be used to discriminate between dead, damaged and live cells." [PMID:29403965] is_a: ARO:3004388 ! in-vitro microbial susceptibility test [Term] id: ARO:3004396 name: mechanism-specific test namespace: antibiotic_resistance def: "Test that directly detect the presence of a particular resistance mechanism." [] is_a: ARO:3004388 ! in-vitro microbial susceptibility test [Term] id: ARO:3004397 name: broth dilution method namespace: antibiotic_resistance def: "The microbial species are inoculated in liquid growth medium containing incremental dilutions (usually 2-fold) of the antimicrobial agent." [PMID:29403965] is_a: ARO:3004388 ! in-vitro microbial susceptibility test [Term] id: ARO:3004398 name: automated testing platform namespace: antibiotic_resistance def: "Automated system of analysis for determining antimicrobial susceptibility." [] is_a: ARO:3004390 ! antimicrobial resistance test platform [Term] id: ARO:3004399 name: manual testing platform namespace: antibiotic_resistance def: "Non-automated system of analysis for determining antimicrobial susceptibility." [] is_a: ARO:3004390 ! antimicrobial resistance test platform synonym: "noncommercial testing platform" EXACT [] [Term] id: ARO:3004400 name: MicroScan namespace: antibiotic_resistance def: "Specific automated system of analysis for determining antimicrobial susceptibility developed by Omron." [] is_a: ARO:3004398 ! automated testing platform [Term] id: ARO:3004401 name: Phoenix namespace: antibiotic_resistance def: "Specific automated system of analysis for determining antimicrobial susceptibility developed by Becton Dickinson." [] is_a: ARO:3004398 ! automated testing platform [Term] id: ARO:3004402 name: Sensitire namespace: antibiotic_resistance def: "Specific automated system of analysis for determining antimicrobial susceptibility developed by Trek, Thermo Fisher Scientific." [] is_a: ARO:3004398 ! automated testing platform [Term] id: ARO:3004403 name: Vitek System namespace: antibiotic_resistance def: "Specific automated system of analysis for determining antimicrobial susceptibility developed by bioMérieux." [] is_a: ARO:3004398 ! automated testing platform [Term] id: ARO:3004404 name: automated testing platform vendor namespace: antibiotic_resistance def: "Vendor of automated system of analysis for determining antimicrobial susceptibility." [] is_a: ARO:3004438 ! AMR testing vendor [Term] id: ARO:3004405 name: Becton Dickinson namespace: antibiotic_resistance def: "Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in New Jersey, USA. Becton Dickinson is the developer of the Phoenix automated testing platform." [] is_a: ARO:3004404 ! automated testing platform vendor [Term] id: ARO:3004406 name: bioMérieux namespace: antibiotic_resistance def: "Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in France. bioMérieux is the developer of the Vitek automated testing platform." [] is_a: ARO:3004404 ! automated testing platform vendor [Term] id: ARO:3004407 name: Siemens namespace: antibiotic_resistance def: "Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in Berlin and Munich." [] is_a: ARO:3004404 ! automated testing platform vendor [Term] id: ARO:3004408 name: Omron namespace: antibiotic_resistance def: "Specific vendor of automated system of analysis for determining antimicrobial susceptibility based in Japan. Omron is the developer of the MicroScan automated testing platform." [] is_a: ARO:3004404 ! automated testing platform vendor [Term] id: ARO:3004409 name: Trek namespace: antibiotic_resistance def: "Specific vendor of automated system of analysis for determining antimicrobial susceptibility that was acquired by Thermo Fisher Scientific Inc. Thermo Fisher Scienfiic Inc. is headquartered in Massachusetts, USA. Trek is the developer of the Sensitire automated testing platform." [] is_a: ARO:3004404 ! automated testing platform vendor synonym: "Thermo Fisher Scientific" EXACT [] [Term] id: NCIT:85701 name: macro broth dilution method namespace: antibiotic_resistance def: "A method to determine the minimum inhibitory concentration (MIC) of antibiotics in which growth media is pipetted into a multi-well plate. Each well contains a known concentration of drug which is inoculated with a known quantity of bacteria. The plate is incubated for a specified period of time and each well is assessed for bacterial cell growth. The drug concentration in the first well showing no growth is known as the MIC for that antibiotic. Minimum 2 mL total broth dilution volume." [PMID:29403965] is_a: ARO:3004397 ! broth dilution method [Term] id: ARO:3004410 name: micro broth dilution method namespace: antibiotic_resistance def: "Broth dilution conducted on 96-well microtiter plates (≤200 µL per well)." [PMID:29403965] is_a: ARO:3004397 ! broth dilution method [Term] id: NCIT:85595 name: disk-diffusion method namespace: antibiotic_resistance def: "A method to determine microbial susceptibility to antibiotics wherein bacteria are inoculated onto agar plates and the antimicrobial agent diffused onto the agar plate from a filter paper disk. An approximate, but not exact, MIC is determined by the diameter of growth inhibition zones. This method has been found to have good correlation between in-vivo data and in-vitro data." [PMID:29403965] is_a: ARO:3004391 ! diffusion method synonym: "Kirby-Bauer disk assay" EXACT [] [Term] id: NCIT:85596 name: antimicrobial gradient method (E-test) namespace: antibiotic_resistance def: "A method to determine microbial susceptibility to antibiotics in which a plastic strip impregnated with the antibiotic of interest is placed on an agar plate that has been inoculated with bacteria. The antibiotic diffuses from the strip producing a concentration gradient of drug on the agar. The point at which the elliptical shaped area of growth inhibition meets the strip is the minimum inhibitory concentration of the drug of interest." [PMID:29403965] is_a: ARO:3004391 ! diffusion method [Term] id: ARO:3004411 name: agar well diffusion method namespace: antibiotic_resistance def: "This test is a common method of evaluating the antimicrobial activity of plants or microbial extracts. In this method, bacteria are inoculated onto agar plates and the antimicrobial agent is injected into the plate and allowed to diffuse." [PMID:29403965] is_a: ARO:3004391 ! diffusion method [Term] id: ARO:3004412 name: agar plug diffusion method namespace: antibiotic_resistance def: "This method is commonly used to study the antagonism between microorganisms. The first bacterial strain is inoculated onto agar plates in tight streaks. The bacteria will secrete molecules that diffuse in the agar medium; this medium is cut and placed on another agar plate inoculated with another microorganism." [PMID:29403965] is_a: ARO:3004391 ! diffusion method [Term] id: ARO:3004413 name: cross streak method namespace: antibiotic_resistance def: "This method is commonly used to study the antagonism between microorganisms. The microbial strain of interest is seeded by a single streak in the center of the agar plate. After incubation, the plate is seeded with the second microorganism by single streak perpendicular to the central streak." [PMID:29403965] is_a: ARO:3004391 ! diffusion method [Term] id: ARO:3004414 name: agar diffusion bioautography namespace: antibiotic_resistance def: "The antimicrobial agent is transferred from a chromatogram to an agar plate previously inoculated with the test microorganism." [PMID:29403965] is_a: ARO:3004392 ! thin-layer chromatography (TLC)-bioautography [Term] id: ARO:3004415 name: direct bioautography namespace: antibiotic_resistance def: "A developed TLC plate is dipped into or sprayed with a microbial suspension and then incubated. Live microbial cells are visualized using tetrazolium salts." [PMID:29403965] is_a: ARO:3004392 ! thin-layer chromatography (TLC)-bioautography [Term] id: ARO:3004416 name: agar overlay bioautography namespace: antibiotic_resistance def: "The TLC plate is covered with a molten agar medium seeded with the test microbe and the antimicrobial compounds are allowed to diffuse onto the agar medium. Tetrazolium dye staining allows for visualization." [PMID:29403965] is_a: ARO:3004392 ! thin-layer chromatography (TLC)-bioautography synonym: "agar overlay bioassay" EXACT [] [Term] id: ARO:3004417 name: inoculum namespace: antibiotic_resistance def: "Concentration at which bacterial cells in suspension, calculated with respect to final volume (colony forming units/milliliter (cfu/mL)). The standard for broth dilution is 5 x 105cfu/mL. The standard for agar dilution is 104cfu/mL." [PMID:18274517] is_a: ARO:3004389 ! reagent or protocol used for testing AMR [Term] id: ARO:3004418 name: growth medium namespace: antibiotic_resistance def: "Medium that supports microorganism growth." [] is_a: ARO:3004389 ! reagent or protocol used for testing AMR [Term] id: ARO:3004419 name: chromogenic cephalosporinase test namespace: antibiotic_resistance def: "Assay for beta lactamase detection." [PMID:34624] is_a: ARO:3004396 ! mechanism-specific test [Term] id: ARO:3004420 name: chloramphenicol acetyltransferase assay (CAT) namespace: antibiotic_resistance def: "Commercial colorimetric assay for detection of chloramphenicol modifying enzyme chloramphenicol acetyltransferase." [PMID:20439409] is_a: ARO:3004396 ! mechanism-specific test [Term] id: ARO:3004421 name: greater than standard inoculum namespace: antibiotic_resistance def: "Greater than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution." [PMID:18274517] is_a: ARO:3004417 ! inoculum [Term] id: ARO:3004422 name: less than standard inoculum namespace: antibiotic_resistance def: "Less than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution." [PMID:18274517] is_a: ARO:3004417 ! inoculum [Term] id: ARO:3004423 name: = standard inoculum namespace: antibiotic_resistance def: "Around equal to 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution." [PMID:18274517] is_a: ARO:3004417 ! inoculum [Term] id: ARO:3004424 name: Mueller-Hinton Broth namespace: antibiotic_resistance def: "General purpose medium used for culture of nonfastidious microorganisms." [] is_a: ARO:3004418 ! growth medium [Term] id: ARO:3004425 name: CO2 supplemented medium namespace: antibiotic_resistance def: "Incubation atmosphere supplemented with CO2." [] is_a: ARO:3004418 ! growth medium [Term] id: ARO:3004426 name: divalent cation supplemented medium namespace: antibiotic_resistance def: "Medium supplementation with 20–25 mg Ca2+ and 10–12.5 mg Mg2+ per liter, which is representative of the divalent cation concentration in blood. Divalent cation supplemented medium is correct to use for susceptibility testing of tetracyclines, daptomycin for gram-positive bacteria and aminoglycosides for Pseudomonas aeruginosarequires." [PMID:1551973] is_a: ARO:3004418 ! growth medium [Term] id: ARO:3004427 name: NaCl supplemented medium namespace: antibiotic_resistance def: "Growth medium supplemented with 2% (wt/vol) sodium chloride for testing susceptibility of Staphylococcus aureus to methicillin, oxacillin and nafcillin." [PMID:12691545] is_a: ARO:3004418 ! growth medium [Term] id: ARO:3004428 name: Difco Mueller-Hinton Broth namespace: antibiotic_resistance def: "Low thymine and thymidine content." [] is_a: ARO:3004424 ! Mueller-Hinton Broth [Term] id: ARO:3004429 name: BBL Mueller-Hinton Broth namespace: antibiotic_resistance def: "High thymine and thymidine content." [] is_a: ARO:3004424 ! Mueller-Hinton Broth [Term] id: ARO:3004430 name: antimicrobial resistance tissue specificity namespace: antibiotic_resistance def: "The tissue type used to select breakpoints from a particular standard, for the interpretation of MIC results." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: HP:0031292 name: cutaneous abscess namespace: antibiotic_resistance def: "A circumscribed area of pus or necrotic debris in the skin." [] is_a: ARO:3004430 ! antimicrobial resistance tissue specificity [Term] id: DOID:13148 name: acute cystitis namespace: antibiotic_resistance def: "A cystitis characterized by a sudden onset or severe symptoms." [] is_a: ARO:3004430 ! antimicrobial resistance tissue specificity [Term] id: UBERON:0003134 name: female reproductive organ namespace: antibiotic_resistance def: "A female organ involved in reproduction." [] is_a: ARO:3004430 ! antimicrobial resistance tissue specificity [Term] id: UBERON:0003135 name: male reproductive organ namespace: antibiotic_resistance def: "A male organ involved in reproduction." [] is_a: ARO:3004430 ! antimicrobial resistance tissue specificity [Term] id: DOID:1579 name: respiratory system disease namespace: antibiotic_resistance def: "A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm." [] is_a: ARO:3004430 ! antimicrobial resistance tissue specificity [Term] id: DOID:37 name: skin disease namespace: antibiotic_resistance def: "An integumentary system disease that is located in the skin." [] is_a: ARO:3004430 ! antimicrobial resistance tissue specificity [Term] id: UBERON:0001003 name: skin epidermis namespace: antibiotic_resistance def: "The outer epithelial layer of the skin that is superficial to the dermis." [] is_a: ARO:3004430 ! antimicrobial resistance tissue specificity [Term] id: SYMP:0000092 name: skin lesion namespace: antibiotic_resistance def: "Skin lesion is a skin and integumentary tissue symptom characterized as an abnormal change in structure of the skin that is especially circumscribed and well defined due to injury or disease." [] is_a: ARO:3004430 ! antimicrobial resistance tissue specificity [Term] id: DOID:0050161 name: lower respiratory tract disease namespace: antibiotic_resistance def: "A respiratory system disease which involves the lower respiratory tract." [] is_a: DOID:1579 ! respiratory system disease [Term] id: DOID:850 name: lung disease namespace: antibiotic_resistance def: "A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide." [] is_a: DOID:0050161 ! lower respiratory tract disease [Term] id: DOID:11162 name: respiratory failure namespace: antibiotic_resistance def: "A lung disease characterized by inadequate gas exchange by the respiratory system." [] is_a: DOID:850 ! lung disease [Term] id: DOID:11394 name: adult respiratory distress sydrome namespace: antibiotic_resistance def: "A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia." [] is_a: DOID:11162 ! respiratory failure [Term] id: DOID:12716 name: newborn respiratory distress syndrome namespace: antibiotic_resistance def: "A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts." [] is_a: DOID:11162 ! respiratory failure [Term] id: ARO:3004431 name: EUCAST antimicrobial phenotype namespace: antibiotic_resistance def: "Qualitative description of a microbial response to antimicrobial agents as described by EUCAST using breakpoints determined through in-vitro testing. These breakpoints are determined irrespective of tissue specificity of infection." [] is_a: ARO:3004299 ! antimicrobial phenotype [Term] id: ARO:3004432 name: wild-type namespace: antibiotic_resistance def: "A microbe whose susceptibility to antibiotics is comparable to that of a reference susceptible microbe, meaning that the microbe is sensitive to the particular antibiotic." [] is_a: ARO:3004431 ! EUCAST antimicrobial phenotype [Term] id: ARO:3004433 name: non wild-type namespace: antibiotic_resistance def: "A microbe whose susceptibility to antibiotics differs from that of a reference susceptible microbe, meaning that the microbe is resistant to the particular antibiotic." [] is_a: ARO:3004431 ! EUCAST antimicrobial phenotype [Term] id: ARO:3004438 name: AMR testing vendor namespace: antibiotic_resistance def: "Vendor of AMR testing equipment and reagents." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: ARO:3004439 name: component of AMR phenotype measurement namespace: antibiotic_resistance def: "Details required in reporting antimicrobial resistance." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: ARO:3004440 name: CLSI antimicrobial phenotype namespace: antibiotic_resistance def: "Qualitative description of a microbial response to antimicrobial agents as described by CLSI using breakpoints that take into consideration tissue specificity of infection." [] is_a: ARO:3004299 ! antimicrobial phenotype [Term] id: ARO:3004441 name: tet(59) namespace: antibiotic_resistance def: "Tet(59) is a chromosome-encoded tetracycline efflux pump described from a Chinese pig manure sample." [PMID:27565618] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(59)" EXACT CARD_Short_Name [] synonym: "tet59" EXACT [] [Term] id: ARO:3004442 name: tet(W/N/W) namespace: antibiotic_resistance def: "tet(W/N/W) is a mosaic tetracycline resistance gene and ribosomal protection protein." [PMID:27565618] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000528 ! chlortetracycline synonym: "tet(W/N/W)" EXACT CARD_Short_Name [] synonym: "tetWNW" EXACT [] [Term] id: ARO:3004443 name: RSA beta-lactamase namespace: antibiotic_resistance def: "A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity." [PMID:29316517] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004444 name: RSA1-1 namespace: antibiotic_resistance def: "RSA1-1 is a class A beta-lactamase resistance enzyme identified from a functional metagenomic study of contaminated river sediments." [PMID:29316517] is_a: ARO:3004443 ! RSA beta-lactamase synonym: "RSA1-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004446 name: Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics namespace: antibiotic_resistance def: "PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics." [PMID:29352811] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000644 ! cefaclor relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3000649 ! cefditoren relationship: confers_resistance_to_antibiotic ARO:3000650 ! cefdinir synonym: "Hinf_PBP3_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3004447 name: HERA beta-lactamase namespace: antibiotic_resistance def: "A class A beta-lactamase family shown to hydrolyze penicillin but without cephalosporinase activity." [PMID:12878539] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004448 name: HERA-1 namespace: antibiotic_resistance def: "A class A beta-lactamase with penicillinase activity described in Atlantibacter (Escherichia) hermannii." [PMID:12878539] is_a: ARO:3004447 ! HERA beta-lactamase synonym: "HER-1" EXACT [] synonym: "HERA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004449 name: TRU beta-lactamase namespace: antibiotic_resistance def: "A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi)." [PMID:20124004] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004450 name: TRU-1 namespace: antibiotic_resistance def: "A class C beta-lactamase enzyme identified from Aeromonas enteropelogenes. TRU-1 confers resistance to penicillin and cephalosporin antibiotics." [PMID:20124004] is_a: ARO:3004449 ! TRU beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "TRU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004451 name: Agrobacterium fabrum chloramphenicol acetyltransferase namespace: antibiotic_resistance def: "A chloramphenicol resistance determinant described in the Gram-negative bacterium Agrobacterium fabrum." [PMID:2013403] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Afab_ACT_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004452 name: Alkalihalobacillus clausii chloramphenicol acetyltransferase namespace: antibiotic_resistance def: "A chloramphenicol resistance determinant described in Alkalihalobacillus clausii." [PMID:19459958] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Acla_ACT_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004454 name: Campylobacter coli chloramphenicol acetyltransferase namespace: antibiotic_resistance def: "A chloramphenicol resistance determinant described in Campylobacter coli." [PMID:2227449] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Ccol_ACT_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004455 name: Streptococcus suis chloramphenicol acetyltransferase namespace: antibiotic_resistance def: "A chloramphenicol resistance determinant described in Streptococcus suis." [PMID:12726767] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Ssui_ACT_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004456 name: Enterococcus faecium chloramphenicol acetyltransferase namespace: antibiotic_resistance def: "A chloramphenicol resistance determinant described in an Enterococcus faecium plasmid." [PMID:12603745] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Efac_ACT_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004457 name: Staphylococcus intermedius chloramphenicol acetyltransferase namespace: antibiotic_resistance def: "A chloramphenicol resistance determinant described in Staphylococcus intermedius." [PMID:1713259] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Sint_ACT_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004458 name: Enterococcus faecalis chloramphenicol acetyltransferase namespace: antibiotic_resistance def: "A chloramphenicol acetyltransferase and resistance determinant described in Enterococcus faecalis." [PMID:11735367] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Efae_ACT_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004460 name: Vibrio anguillarum chloramphenicol acetyltransferase namespace: antibiotic_resistance def: "A chloramphenicol resistance determinant described in a Vibrio anguillarum plasmid sequence." [PMID:1406372] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Vang_ACT_CHL" EXACT CARD_Short_Name [] [Term] id: ARO:3004462 name: delafloxacin namespace: antibiotic_resistance def: "Delafloxacin is a novel fluoroquinolone antibiotic, differentiated from other on-market fluoroquinolones by the absence of a protonatable substituent conferring a weakly acidic character to the molecule. This property results in increased intracellular penetration and enhanced bactericidal activity under acidic conditions." [PMID:29605887] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:487101 [Term] id: ARO:3004463 name: EBR-2 namespace: antibiotic_resistance def: "EBR-2 is a novel EBR-like class B beta-lactamase isolated from an extensively drug-resistant strain of Empedobacter falsenii." [PMID:29687150] is_a: ARO:3004204 ! EBR beta-lactamase synonym: "EBR-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004464 name: CFE-2 namespace: antibiotic_resistance def: "CFE-2 is a plasmid-encoded AmpC beta-lactamase first described from Citrobacter freundii by Chen et al. 2018." [PMID:29944954] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CFE-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004465 name: intrinsic colistin resistant phosphoethanolamine transferase namespace: antibiotic_resistance def: "Chromosomally-encoded phosphoethanolamine (PEtN) transferases shown to confer resistance to polymyxin antibiotics, including colistin." [] is_a: ARO:3004112 ! phosphoethanolamine transferase conferring colistin resistance relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3004466 name: ICR-Mc namespace: antibiotic_resistance def: "A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella catarrhalis. ICR-Mc is the protein that represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases." [PMID:29631403] is_a: ARO:3004465 ! intrinsic colistin resistant phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "ICR-Mc" EXACT CARD_Short_Name [] [Term] id: ARO:3004467 name: ciprofloxacin phosphotransferase namespace: antibiotic_resistance def: "A class of phosphotransferase enzymes shown to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation. The sole example, CrpP, was thought to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation, however in the paper by Zubyk & Wright (2021) this was discovered to not be the case. There are no known experimentally validated examples of enzymes with this function." [PMID:34001507, PMID:29581123] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: participates_in ARO:3000105 ! phosphorylation of antibiotic conferring resistance synonym: "CrpP" EXACT [] [Term] id: ARO:3004469 name: ABC-F ATP-binding cassette ribosomal protection protein namespace: antibiotic_resistance def: "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins." [PMID:29376318, PMID:27006457] is_a: ARO:3000185 ! antibiotic target protection protein [Term] id: ARO:3004470 name: poxtA namespace: antibiotic_resistance def: "PoxtA is an ABC-F subfamily ATP-binding cassette protein that confers resistance to tetracycline, -phenicol, and oxazolidinone via modification of the bacterial ribosome. The encoding gene was isolated from a methicillin-resistant Staphylococcus aureus strain." [PMID:29635422] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol synonym: "poxtA" EXACT CARD_Short_Name [] [Term] id: ARO:3004471 name: msr-type ABC-F protein namespace: antibiotic_resistance def: "msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms." [] is_a: ARO:3004469 ! ABC-F ATP-binding cassette ribosomal protection protein relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic [Term] id: ARO:3004472 name: lsa-type ABC-F protein namespace: antibiotic_resistance def: "A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome." [] is_a: ARO:3004469 ! ABC-F ATP-binding cassette ribosomal protection protein relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic relationship: confers_resistance_to_drug_class ARO:0000026 ! streptogramin antibiotic relationship: confers_resistance_to_drug_class ARO:3000670 ! pleuromutilin antibiotic [Term] id: ARO:3004473 name: tebipenem namespace: antibiotic_resistance def: "A carbapenem antibiotic, administered as the oral drug tebipenem-pivoxil, shown to be effective at treating bacterial infections." [PMID:30014729] is_a: ARO:0000020 ! carbapenem xref: pubchem.compound:9800194 [Term] id: ARO:3004474 name: cefiderocol namespace: antibiotic_resistance def: "A siderophore cephalosporin with antibiotic activity against Gram-negative pathogens including and specifically Pseudomonas aeruginosa." [PMID:29960205] is_a: ARO:0000032 ! cephalosporin xref: pubchem.compound:77843966 [Term] id: ARO:3004476 name: vmlR namespace: antibiotic_resistance def: "vmlR is an ABC-F ATPase ribosomal protection protein identified in Bacillus subtilus. Shown to confer resistance to lincomycin and streptogramin A virginiamycin. Described by Crowe-McAuliffe et al. 2018." [PMID:30126986, PMID:36951104] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3000677 ! virginiamycin S2 relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin relationship: confers_resistance_to_antibiotic ARO:3007636 ! iboxamycin relationship: confers_resistance_to_antibiotic ARO:3007638 ! hygromycin A relationship: confers_resistance_to_antibiotic ARO:3007639 ! A201A synonym: "vmlR" EXACT CARD_Short_Name [] [Term] id: ARO:3004477 name: eremomycin pyrrolidide namespace: antibiotic_resistance def: "Eremomycin pyrrolidide 3, 4, 5, and 6 are semisynthetic glycopeptide derived from vancomycin or eremomycin. There have high activity against staphylococci and enterococci, including vancomycin-resistant strains." [PMID:30237697] is_a: ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3004478 name: OXA-665 namespace: antibiotic_resistance def: "Beta-lactamase found in Acinetobacter rudis efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins." [PMID:30247543] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-665" EXACT CARD_Short_Name [] [Term] id: ARO:3004479 name: OXA-664 namespace: antibiotic_resistance def: "Beta-lactamase found in Acinetobacter spp. efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins." [PMID:30247543] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-664" EXACT CARD_Short_Name [] [Term] id: ARO:3004480 name: Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin namespace: antibiotic_resistance def: "Bifidobacterium are antibiotic resistant probiotics are prescribed to upkeep the population beneficial bacteria in the gut microbiome. However, horizontal gene transfer among gut microbes could create harmful antibiotic-resistant pathogenic bacteria, such as Mycobacterium tuberculosis. Lokesh et al. analyzed Bifidobacterium antitubercular drug resistance and mutations in rpoB. They found that B. animalis, B. longum and B. adolescentis showed considerable resistance to pyrazinamide, isoniazid, and streptomycin, while B. adolescentis had mutations both in the rifampicin (RIF) pocket and in regions outside the pockets, and also showed considerable resistance to RIF." [PMID:30093677] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "Bado_rpoB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3004489 name: OXA-663 namespace: antibiotic_resistance def: "An OXA-10 family class beta-lactamase identified from a Klebsiella pneumoniae BIDMC 35 isolate." [PMID:30126962] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-663" EXACT CARD_Short_Name [] [Term] id: ARO:3004490 name: delamanid namespace: antibiotic_resistance def: "A novel nitroimidazole antibiotic for treating Mycobacterium tuberculosis infection. Delamanid inhibits bacterial cell wall growth by mycolic acid synthesis disruption and is particularly effective in combination therapies against multidrug-resistant tuberculosis." [PMID:25210407] is_a: ARO:3004115 ! nitroimidazole antibiotic synonym: "deltyba" EXACT [] xref: pubchem.compound:6480466 [Term] id: ARO:3004491 name: diarylquinoline antibiotic namespace: antibiotic_resistance def: "A class of antibiotics used to treat specifically Mycobacterium tuberculosis infection; therefore, referred to as an antimycobacterial. Diarylquinoline antibiotics inhibit ATP synthesis in tuberculosis cells by disruption of mycobacterial ATP synthase." [PMID:24130398] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3004492 name: bedaquiline namespace: antibiotic_resistance def: "A diarylquinoline antibiotic drug sold under the brand name Sirturo, used to treat infection from Mycobacterium spp., particularly multidrug-resistant tuberculosis. Bedaquiline disrupts ATP synthase by proton pump blockage, inhibiting ATP synthesis." [PMID:24130398] is_a: ARO:3004491 ! diarylquinoline antibiotic synonym: "Sirturo" EXACT [] xref: pubchem.compound:5388906 [Term] id: ARO:3004493 name: ADC-68 namespace: antibiotic_resistance def: "A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii." [PMID:25372683] is_a: ARO:3004545 ! ADC beta-lactamase with carbapenemase activity synonym: "ADC-68" EXACT CARD_Short_Name [] [Term] id: ARO:3004494 name: IMP-55 namespace: antibiotic_resistance def: "An IMP class B metallo-beta-lactamase enzyme identified from Acinetobacter baumannii." [PMID:28336429] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-55" EXACT CARD_Short_Name [] [Term] id: ARO:3004495 name: IMP-56 namespace: antibiotic_resistance def: "An IMP class B metallo-beta-lactamase enzyme identified from carbapenem-resistant Pseudomonas aeruginosa." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-56" EXACT CARD_Short_Name [] [Term] id: ARO:3004496 name: KPC-24 namespace: antibiotic_resistance def: "A KPC class A beta-lactamase and carbapenemase identified from Chilean isolates of Klebsiella pneumoniae." [PMID:27436389] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-24" EXACT CARD_Short_Name [] [Term] id: ARO:3004498 name: dfrB4 namespace: antibiotic_resistance def: "A trimethoprim-resistant dihydrofolate reductase characterized on a class I integron from an E. coli isolate." [PMID:28242670] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA2d" EXACT [] synonym: "dfrB4" EXACT CARD_Short_Name [] [Term] id: ARO:3004499 name: Tosufloxacin namespace: antibiotic_resistance def: "Tosufloxacin is a fluoroquinolone antibiotic with an extended spectrum of activity." [PMID:1906696] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:5517 [Term] id: ARO:3004500 name: MCR-3.11 namespace: antibiotic_resistance def: "An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant differing by 2 amino acid substitutions, identified from an Escherichia coli isolate." [PMID:29760138] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.11" EXACT CARD_Short_Name [] [Term] id: ARO:3004501 name: MCR-6.1 namespace: antibiotic_resistance def: "An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in the United Kingdom." [PMID:30053008] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-6.1" EXACT CARD_Short_Name [] [Term] id: ARO:3004502 name: MCR-2.2 namespace: antibiotic_resistance def: "An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in Great Britain." [PMID:29091227, PMID:29091193] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004110 ! MCR-2.1 synonym: "MCR-2.2" EXACT CARD_Short_Name [] [Term] id: ARO:3004503 name: MCR-3.6 namespace: antibiotic_resistance def: "An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Aeromonas." [PMID:29394397] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.6" EXACT CARD_Short_Name [] [Term] id: ARO:3004504 name: MCR-3.10 namespace: antibiotic_resistance def: "An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from Aeromonas, Proteus and Escherichia coli." [PMID:29203482] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.10" EXACT CARD_Short_Name [] [Term] id: ARO:3004505 name: MCR-3.5 namespace: antibiotic_resistance def: "An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an extensively-resistant Escherichia coli clinical isolate." [PMID:30053115, PMID:28971871] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.5" EXACT CARD_Short_Name [] [Term] id: ARO:3004506 name: MCR-1.10 namespace: antibiotic_resistance def: "An MCR-1 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an Escherichia porcine isolate in Great Britain." [PMID:29091227] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.10" EXACT CARD_Short_Name [] [Term] id: ARO:3004507 name: MCR-1.9 namespace: antibiotic_resistance def: "An MCR-1 phosphoethanolamine transferase and polymyxin resistance gene variant identified from an enterotoxigenic Escherichia coli clinical isolate." [PMID:29922243] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.9" EXACT CARD_Short_Name [] [Term] id: ARO:3004508 name: MCR-3.9 namespace: antibiotic_resistance def: "An MCR-3 polymyxin (incl. colistin) resistance gene variant isolated from an Aeromonas isolate." [PMID:29394397] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.9" EXACT CARD_Short_Name [] [Term] id: ARO:3004509 name: MCR-3.8 namespace: antibiotic_resistance def: "An MCR-3 polymyxin (incl. colistin) resistance gene variant identified from an Aeromonas isolate." [PMID:29394397] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.8" EXACT CARD_Short_Name [] [Term] id: ARO:3004510 name: MCR-3.7 namespace: antibiotic_resistance def: "An MCR polymyxin (colistin) resistance gene variant identified in Aeromonas." [PMID:29394397] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.7" EXACT CARD_Short_Name [] [Term] id: ARO:3004511 name: MCR-3.2 namespace: antibiotic_resistance def: "An MCR-3 polymyxin resistance gene variant identified in a colistin-resistant Salmonella isolate from Canada, located on an IncHI-2 plasmid." [PMID:30351266] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.2" EXACT CARD_Short_Name [] [Term] id: ARO:3004513 name: MCR-1.6 namespace: antibiotic_resistance def: "An MCR-1 polymyxin resistance gene variant identified from colistin-resistant Salmonella enterica (serovar typhimurium) isolate, carried by an IncP plasmid." [PMID:28264851] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.6" EXACT CARD_Short_Name [] [Term] id: ARO:3004514 name: MCR-1.3 namespace: antibiotic_resistance def: "An MCR-1 polymyxin resistance gene variant identified from a poultry Raoultella planticola isolate." [PMID:29778190, PMID:28242671] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.3" EXACT CARD_Short_Name [] [Term] id: ARO:3004515 name: MCR-1.4 namespace: antibiotic_resistance def: "An MCR-1 polymyxin resistance gene variant identified from a colistin-resistant Escherichia coli isolate." [PMID:29118748] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.4" EXACT CARD_Short_Name [] [Term] id: ARO:3004516 name: MCR-8.1 namespace: antibiotic_resistance def: "A novel phosphoethanolamine transferase and mobile colistin resistance gene identified from carbapenem-resistant NDM-1-producing Klebsiella pneumoniae." [PMID:29970891] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-8.1" EXACT CARD_Short_Name [] [Term] id: ARO:3004517 name: MCR-7.1 namespace: antibiotic_resistance def: "A novel plasmid-mediated colistin-resistant phosphoethanolamine transferase identified from a poultry isolate of Klebsiella pneumoniae." [PMID:29912417] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-7.1" EXACT CARD_Short_Name [] [Term] id: ARO:3004519 name: MIC sign namespace: antibiotic_resistance def: "MIC sign (>, <, =) of the MIC value." [] is_a: ARO:3004439 ! component of AMR phenotype measurement relationship: part_of ARO:3004370 ! minimum inhibitory concentration (MIC) [Term] id: ARO:3004520 name: > namespace: antibiotic_resistance def: "Greater than MIC value." [] is_a: ARO:3004519 ! MIC sign [Term] id: ARO:3004521 name: < namespace: antibiotic_resistance def: "Less than MIC value." [] is_a: ARO:3004519 ! MIC sign [Term] id: ARO:3004522 name: = namespace: antibiotic_resistance def: "Equal to MIC value." [] is_a: ARO:3004519 ! MIC sign [Term] id: ARO:3004523 name: MIC range namespace: antibiotic_resistance def: "MIC is a range of two MIC values (e.g., given 10 clinical isolates with a resistance determinant, there are 5 that have an MIC of 25ug/mL and 5 that have an MIC of 100ug/mL agaisnt tobramycin)." [] is_a: ARO:3004519 ! MIC sign [Term] id: ARO:3004524 name: strain type namespace: antibiotic_resistance def: "Strain type used for antibiotic susceptibility testing." [] is_a: ARO:3004389 ! reagent or protocol used for testing AMR [Term] id: ARO:3004525 name: resistance determinant in strain namespace: antibiotic_resistance def: "Resistant determinant is identified in strain without any experimental methods." [] is_a: ARO:3004524 ! strain type [Term] id: ARO:3004526 name: deletion of resistance determinant namespace: antibiotic_resistance def: "Experimental deletion of resistance determinant in the chromosome of the strain initially with this resistance determinant." [] is_a: ARO:3004524 ! strain type [Term] id: ARO:3004527 name: deletion of resistance determinant with plasmid harbouring resistance determinant namespace: antibiotic_resistance def: "Experimental protocol where there is a deletion of resistance determinant and the transformation of a plasmid harbouring resistance determinant into the same strain." [] is_a: ARO:3004524 ! strain type [Term] id: ARO:3004528 name: plasmid harbouring resistance determinant namespace: antibiotic_resistance def: "Experimental procedure where plasmid harbouring a resistance determinant is transformed into a strain." [] is_a: ARO:3004524 ! strain type [Term] id: ARO:3004529 name: resistance determinant not in strain namespace: antibiotic_resistance def: "Without any experimental protocol, the resistance determinant is absent from the strain." [] is_a: ARO:3004524 ! strain type [Term] id: ARO:3004530 name: insertion of resistance determinant namespace: antibiotic_resistance def: "Experimental insertion of resistance determinant in the chromosome of the strain initially without this resistance determinant." [] is_a: ARO:3004524 ! strain type [Term] id: ARO:3004531 name: strain namespace: antibiotic_resistance def: "Specific strain of bacteria that was used to perform the antibiotic susceptibility test." [] is_a: ARO:3004389 ! reagent or protocol used for testing AMR [Term] id: ARO:3004532 name: strain source namespace: antibiotic_resistance def: "Source of the strain used in the antibiotic susceptibility test (e.g., clinical, environmental, agriculture)." [] is_a: ARO:3004389 ! reagent or protocol used for testing AMR [Term] id: ARO:3004533 name: clinical source namespace: antibiotic_resistance def: "Strain isolated in a clinical setting (e.g., from a patient)." [] is_a: ARO:3004532 ! strain source [Term] id: ARO:3004534 name: environmental source namespace: antibiotic_resistance def: "Strain collected from environment (e.g., soil, water)." [] is_a: ARO:3004532 ! strain source [Term] id: ARO:3004535 name: agricultural source namespace: antibiotic_resistance def: "Strain collected from agricultural setting (e.g., chicken, pig)." [] is_a: ARO:3004532 ! strain source [Term] id: ARO:3004536 name: antimicrobial susceptibility test control namespace: antibiotic_resistance def: "The control of the antibiotic susceptibility testing, whether there was an experimental control (same strain, with and without resistance determinant) or if there was a group of clinical isolates found to have a resistance determinant compared against a strain without that resistance determinant." [] is_a: ARO:3004389 ! reagent or protocol used for testing AMR [Term] id: ARO:3004537 name: experimental control namespace: antibiotic_resistance def: "Antimicrobial susceptibility testing was performed on the same strain with and without a resistance determinant." [] is_a: ARO:3004536 ! antimicrobial susceptibility test control [Term] id: ARO:3004538 name: correlative control namespace: antibiotic_resistance def: "Antibiotic susceptibility testing is performed on a group of clinical isolates with a resistance determinant compared to different strains that do not have this resistance determinant. No experiment was performed to delete / insert the resistance determinant to determine antibiotic susceptibility using the same genetic background." [] is_a: ARO:3004536 ! antimicrobial susceptibility test control [Term] id: ARO:3004539 name: mphH namespace: antibiotic_resistance def: "A chromosomal macrolide 2'-phosphotransferase and resistance gene identified from a Brachybacterium faecium cave isolate." [PMID:22509370, PMID:29317655] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "mphH" EXACT CARD_Short_Name [] [Term] id: ARO:3004540 name: experimental source namespace: antibiotic_resistance def: "Source is an experimental, commonly used lab strain (e.g., P. aeruginosa PAO1)." [] is_a: ARO:3004532 ! strain source [Term] id: ARO:3004541 name: mphK namespace: antibiotic_resistance def: "A chromosomal macrolide phosphotransferase identified from Bacillus subtilis." [PMID:29317655] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "mphK" EXACT CARD_Short_Name [] [Term] id: ARO:3004542 name: mphN namespace: antibiotic_resistance def: "A macrolide phosphotransferase identified on a plasmid in Exiguobacterium." [PMID:24362420, PMID:29317655] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "mphN" EXACT CARD_Short_Name [] [Term] id: ARO:3004543 name: mphO namespace: antibiotic_resistance def: "A chromosomal macrolide phosphostransferase identified in Brachybacterium paraconglomeratum." [PMID:29317655, PMID:22509370] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "mphO" EXACT CARD_Short_Name [] [Term] id: ARO:3004544 name: mphJ namespace: antibiotic_resistance def: "A chromosomal macrolide phosphotransferase identified in Brevibacillus brevis VM4." [PMID:29317655, PMID:29259290] is_a: ARO:3000333 ! macrolide phosphotransferase (MPH) relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000057 ! telithromycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin synonym: "mphJ" EXACT CARD_Short_Name [] [Term] id: ARO:3004545 name: ADC beta-lactamase with carbapenemase activity namespace: antibiotic_resistance def: "ADC beta-lactamase enzymes with demonstrable carbapenemase activity, an exception amongst these enzymes." [PMID:25372683] is_a: ARO:3005459 ! ADC beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004546 name: Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin namespace: antibiotic_resistance def: "Point mutations in the 23S ribosomal RNA domain of Campylobacter jejuni which confer resistance to macrolide antibiotics, including erythromycin." [PMID:12604552] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Cjej_23S_ERY" EXACT CARD_Short_Name [] [Term] id: ARO:3004547 name: dfrA6 namespace: antibiotic_resistance def: "A dihydrofolate reductase and antibiotic resistance gene identified from an integron in Vibrio cholerae." [PMID:19704128] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfr6" EXACT [] synonym: "dfrA6" EXACT CARD_Short_Name [] [Term] id: ARO:3004548 name: dfrA9 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene identified from porcine isolates of Esherichia coli." [PMID:1659308] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfr9" EXACT [] synonym: "dfrA9" EXACT CARD_Short_Name [] synonym: "dfrIX" EXACT [] [Term] id: ARO:3004549 name: dfrB5 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene identified from an integron in Pseudomonas aeruginosa." [PMID:16048978] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfr-lie" EXACT [] synonym: "dfrB5" EXACT CARD_Short_Name [] [Term] id: ARO:3004550 name: dfrA27 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene from non-O1, non-O139 Vibrio cholerae." [PMID:25870070] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA27" EXACT CARD_Short_Name [] [Term] id: ARO:3004551 name: dfrA28 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene from Aeromonas hydrophilia." [PMID:21764945] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA28" EXACT CARD_Short_Name [] [Term] id: ARO:3004552 name: dfrA30 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene from Klebsiella pneumoniae." [PMID:21595893] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA30" EXACT CARD_Short_Name [] [Term] id: ARO:3004554 name: dfrA29 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene isolated from canine Escherichia coli infection." [PMID:27302904] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA29" EXACT CARD_Short_Name [] [Term] id: ARO:3004555 name: dfrA32 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene identified from non-typhoidal multidrug-resistant Salmonella enterica." [PMID:19921331] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA32" EXACT CARD_Short_Name [] [Term] id: ARO:3004556 name: dfrB7 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene identified on an integron in multidrug-resistant gram-negative bacteria." [PMID:21627486] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrB7" EXACT CARD_Short_Name [] synonym: "dfrB8" EXACT [] [Term] id: ARO:3004558 name: CAM beta-lactamase namespace: antibiotic_resistance def: "CAM (Central Alberta Metallo) beta-lactamases are class B metallo-beta-lactamases and carbapenemases found to confer resistance to broad spectrum antibiotics in Pseudomonas aeruginosa." [PMID:30789204] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004559 name: CAM-1 namespace: antibiotic_resistance def: "CAM-1 is a CAM (Central Alberta Metallo) beta-lactamase and carbapenemase identified from 4 clinical isolates of Pseudomonas aeruginosa from a Canadian hospital." [PMID:30789204] is_a: ARO:3004558 ! CAM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000640 ! doripenem relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3003927 ! ceftolozane synonym: "CAM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004560 name: murG transferase namespace: antibiotic_resistance def: "murG acetylglucosaminyltransferase enzymes inhibited by vancomycin. Mutations in murG confer resistance to vancomycin through antibiotic target alteration." [PMID:23887866] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3004561 name: Clostridioides difficile murG with mutation conferring resistance to vancomycin namespace: antibiotic_resistance def: "Mutations in murG which confer resistance to vancomycin in Clostridioides difficile." [PMID:23887866] is_a: ARO:3004560 ! murG transferase relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "Cdif_murG_VAN" EXACT CARD_Short_Name [] [Term] id: ARO:3004562 name: Clostridioides difficile gyrB conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in gyrB of Clostridioides difficile conferring resistance to fluoroquinolone antibiotics." [PMID:27842877, PMID:22508299, PMID:20226332, PMID:18480338, PMID:12384345] is_a: ARO:3000864 ! fluoroquinolone resistant gyrB relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3007165 ! gemifloxacin synonym: "Cdif_gyrB_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3004563 name: Clostridioides difficile rpoB with mutation conferring resistance to rifampicin namespace: antibiotic_resistance def: "Point mutations in the rpoB region of Clostridioides difficile which confer resistance to rifampin and rifampicin antibiotics." [PMID:18559647, PMID:23887866, PMID:19140738, PMID:22908175, PMID:29383668, PMID:22361457, PMID:21998414] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin synonym: "Cdif_rpoB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3004564 name: unclassified resistance-modifying agents namespace: antibiotic_resistance def: "Resistance-modifying agent (RMA) without characterized mechanism which do not exhibit antibiotic activity on their own, but improve the performance of antibiotic drugs." [PMID:27657810, PMID:29264917] is_a: ARO:0000076 ! resistance-modifying agents [Term] id: ARO:3004565 name: tetracyclic indoline namespace: antibiotic_resistance def: "A class of resistance-modifying agents and beta-lactam potentiators which selectively potentiate beta-lactam antibiotics, specifically Amoxicillin-clavulanic acid, in methicillin-resistant Staphylococcus aureus (MRSA) without their own antimicrobial activity." [PMID:27657810] is_a: ARO:3004564 ! unclassified resistance-modifying agents [Term] id: ARO:3004566 name: Rifalazil namespace: antibiotic_resistance def: "Rifalazil is a rifamycin derivative antibiotic, sometimes used for treating Clostridioides difficile infections." [PMID:12556219] is_a: ARO:3000157 ! rifamycin antibiotic xref: pubchem.compound:135431094 [Term] id: ARO:3004567 name: Ramoplanin namespace: antibiotic_resistance def: "Ramoplanin is a glycolipodepsipeptide antibiotic derived from gram-positive Actinoplanes used to treat infection with Clostridioides difficile." [PMID:25182650] is_a: ARO:3000035 ! lipopeptide antibiotic xref: pubchem.compound:16132338 [Term] id: ARO:3004568 name: dfrA18 namespace: antibiotic_resistance def: "A trimethoprim-resistant dihydrofolate reductase identified from Vibrio cholerae." [PMID:11600347] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfr18" EXACT [] synonym: "dfrA18" EXACT CARD_Short_Name [] [Term] id: ARO:3004569 name: ICR-Mo namespace: antibiotic_resistance def: "A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella osloensis. ICR-Mo represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases." [PMID:29758020] is_a: ARO:3004465 ! intrinsic colistin resistant phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "ICR-Mo" EXACT CARD_Short_Name [] [Term] id: ARO:3004570 name: PNGM beta-lactamase namespace: antibiotic_resistance def: "PNGM is a family of metallo-beta-lactamases first identified from a deep-sea sediment metagenome and shown to reduce antibiotic susceptibility by hydrolysis of penicillins, carbapenems and extended- and broad-spectrum cephalosporins." [PMID:29842976] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004571 name: PNGM-1 namespace: antibiotic_resistance def: "PNGM-1 is a subclass B3 metallo-beta-lactamase first identified from a deep-sea sediment meta-genome. PNGM-1 is shown to reduce susceptibility to extended- and broad-spectrum cephalosporins, carbapenems, and penicillins. PNGM-1 is a novel metallo-beta-lactamase which predates the current antibiotic era." [PMID:29842976] is_a: ARO:3004570 ! PNGM beta-lactamase synonym: "PNGM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004572 name: Staphylococcus aureus LmrS namespace: antibiotic_resistance def: "MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid." [PMID:20855745] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol synonym: "A0A3M7YRP9" EXACT [] synonym: "A0A3P0BBR7" EXACT [] synonym: "F6MF49" EXACT [] synonym: "Saur_LmrS" EXACT CARD_Short_Name [] [Term] id: ARO:3004573 name: Acinetobacter baumannii AbaF namespace: antibiotic_resistance def: "Expression of abaF in E. coli resulted in increased resistance to fosfomycin." [PMID:27650185] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Abau_AbaF" EXACT CARD_Short_Name [] synonym: "P0DPR5" EXACT [] [Term] id: ARO:3004574 name: Acinetobacter baumannii AbaQ namespace: antibiotic_resistance def: "AbaQ is an MFS transporter mainly involved in the extrusion of quinolone-type drugs in A. baumannii." [PMID:29941648] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic synonym: "Abau_AbaQ" EXACT CARD_Short_Name [] synonym: "P0DPR4" EXACT [] [Term] id: ARO:3004575 name: S-adenosylmethionine (SAM) superfamily namespace: antibiotic_resistance def: "Members of the radical SAM superfamily are involved in a wide variety of reactions, including unusual methylations, isomerization, sulfur insertion, ring formation, anaerobic oxidation, and protein radical formation." [] is_a: ARO:3004274 ! 23S ribosomal RNA methyltransferase [Term] id: ARO:3004576 name: tet(61) namespace: antibiotic_resistance def: "A tetracycline-resistance ribosomal protection protein." [PMID:33866063] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline synonym: "tet(61)" EXACT CARD_Short_Name [] [Term] id: ARO:3004577 name: Acinetobacter baumannii AmvA namespace: antibiotic_resistance def: "AmvA has 14 alpha-helical transmembrane segments, qualifying it as a member of the DHA2 transporter family of the major facilitator superfamily (MFS). When AmvA was expressed in E. coli, the cells had at least four-fold decreased susceptibility to erythromycin, acridine orange, acriflavine, deoxycholate and methyl viologen. AmvA from the AC0037 strain of A. baumannii was tested." [PMID:20573661] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine synonym: "Abau_AmvA" EXACT CARD_Short_Name [] synonym: "B0V737" EXACT [] [Term] id: ARO:3004578 name: Acinetobacter baumannii AbuO namespace: antibiotic_resistance def: "AbuO is akin to the TolC outer membrane efflux protein. Deletion in A. baumannii results in increased susceptibility to antibiotics including amikacin, carbenicillin, ceftriaxone, meropenem, streptomycin, and tigecycline as well as disinfectants benzyalkonium chloride and chlorhexidine." [PMID:25512405] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000043 ! carbenicillin relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3003823 ! benzalkonium chloride relationship: confers_resistance_to_antibiotic ARO:3007039 ! chlorhexidine relationship: confers_resistance_to_drug_class ARO:3000008 ! penam synonym: "A0A225SC95" EXACT [] synonym: "Abau_AbuO" EXACT CARD_Short_Name [] synonym: "Q2FD57" EXACT [] [Term] id: ARO:3004580 name: Klebsiella pneumoniae KpnE namespace: antibiotic_resistance def: "KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan." [PMID:23836167] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: part_of ARO:3004585 ! Klebsiella pneumoniae KpnEF synonym: "A6T8S5" EXACT [] synonym: "Kpne_KpnE" EXACT CARD_Short_Name [] [Term] id: ARO:3004581 name: tet(48) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(48)" EXACT CARD_Short_Name [] [Term] id: ARO:3004582 name: tet(49) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(49)" EXACT CARD_Short_Name [] [Term] id: ARO:3004583 name: Klebsiella pneumoniae KpnF namespace: antibiotic_resistance def: "KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan." [PMID:23836167] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: part_of ARO:3004585 ! Klebsiella pneumoniae KpnEF synonym: "A6T8S6" EXACT [] synonym: "Kpne_KpnF" EXACT CARD_Short_Name [] [Term] id: ARO:3004584 name: tet(50) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(50)" EXACT CARD_Short_Name [] [Term] id: ARO:3004585 name: Klebsiella pneumoniae KpnEF namespace: antibiotic_resistance def: "KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan." [PMID:23836167] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: confers_resistance_to_antibiotic ARO:3000870 ! triclosan relationship: confers_resistance_to_antibiotic ARO:3003823 ! benzalkonium chloride relationship: confers_resistance_to_antibiotic ARO:3007039 ! chlorhexidine [Term] id: ARO:3004586 name: tet(51) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(51)" EXACT CARD_Short_Name [] [Term] id: ARO:3004587 name: tet(52) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(52)" EXACT CARD_Short_Name [] [Term] id: ARO:3004588 name: Klebsiella pneumoniae KpnG namespace: antibiotic_resistance def: "KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin." [PMID:24823362] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: part_of ARO:3004598 ! Klebsiella pneumoniae KpnGH-TolC synonym: "C8T8U1" EXACT [] synonym: "Kpne_KpnG" EXACT CARD_Short_Name [] [Term] id: ARO:3004589 name: tet(53) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(53)" EXACT CARD_Short_Name [] [Term] id: ARO:3004590 name: tet(54) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(54)" EXACT CARD_Short_Name [] [Term] id: ARO:3004591 name: tet(55) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(55)" EXACT CARD_Short_Name [] [Term] id: ARO:3004592 name: erm(32) namespace: antibiotic_resistance def: "erm(32) is a rRNA methyltransferase. Encodes methyltransferases that modify 23S rRNA." [PMID:10348045] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:3001226 ! narbomycin relationship: confers_resistance_to_antibiotic ARO:3001232 ! methymycin relationship: confers_resistance_to_antibiotic ARO:3001233 ! pikromycin synonym: "erm(32)" EXACT CARD_Short_Name [] [Term] id: ARO:3004595 name: erm(45) namespace: antibiotic_resistance def: "Erm45 is an rRNA methylase that confers resistances to macrolide, lincosamide, and streptogramin B." [PMID:25779586] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA synonym: "erm(45)" EXACT CARD_Short_Name [] [Term] id: ARO:3004596 name: erm(46) namespace: antibiotic_resistance def: "erm(46) is transferable determinant that confers resistance to macrolides." [PMID:26377866] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "ErmREQ" EXACT [] synonym: "erm(46)" EXACT CARD_Short_Name [] [Term] id: ARO:3004597 name: Klebsiella pneumoniae KpnH namespace: antibiotic_resistance def: "KpnH consists of ~511 residues, resembles EmrB of E. coli, and is probably a translocase in the KpnGH-TolC efflux protein in K. pneumoniae. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin." [PMID:24823362] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: part_of ARO:3004598 ! Klebsiella pneumoniae KpnGH-TolC synonym: "A0A3F3BH25" EXACT [] synonym: "Kpne_KpnH" EXACT CARD_Short_Name [] [Term] id: ARO:3004598 name: Klebsiella pneumoniae KpnGH-TolC namespace: antibiotic_resistance def: "Disruption of the pump components KpnGH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin." [PMID:24823362] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000014 ! gentamicin C relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000625 ! polymyxin B1 relationship: confers_resistance_to_antibiotic ARO:3000626 ! polymyxin B2 relationship: confers_resistance_to_antibiotic ARO:3000627 ! polymyxin B3 relationship: confers_resistance_to_antibiotic ARO:3000628 ! polymyxin B4 relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004599 name: clcD namespace: antibiotic_resistance def: "clcD gene can provide resistance to representatives of five of the six antibiotic groups previously shown to be affected by Cfr. clcD was originally found in Clostridioides difficile and is cfr-like." [PMID:26149991] is_a: ARO:3004607 ! Cfr Group relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3004022 ! quinupristin-dalfopristin synonym: "clcD" EXACT CARD_Short_Name [] [Term] id: ARO:3004600 name: LnuH namespace: antibiotic_resistance def: "LnuH is a lincosamide nucleotidyltransferase transferase." [PMID:28843817] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "LnuH" EXACT CARD_Short_Name [] [Term] id: ARO:3004601 name: LnuP namespace: antibiotic_resistance def: "LnuP is a lincosamide nucleotidyltransferase major efflux facilitator." [PMID:19684139] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin synonym: "LnuP" EXACT CARD_Short_Name [] [Term] id: ARO:3004603 name: tet(56) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(56)" EXACT CARD_Short_Name [] [Term] id: ARO:3004605 name: ermZ namespace: antibiotic_resistance def: "ermZ is an methyltransferase modifying 23S rRNA conferring resistance to Spiramycin." [PMID:18048924] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin synonym: "ermZ" EXACT CARD_Short_Name [] synonym: "srm7" EXACT [] synonym: "srmD" EXACT [] [Term] id: ARO:3004606 name: erm(40) namespace: antibiotic_resistance def: "erm(40) is an adenine RNA methylase and confers intrinsic resistance in Mycobacteria." [PMID:17005837] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin synonym: "erm(40)" EXACT CARD_Short_Name [] [Term] id: ARO:3004607 name: Cfr Group namespace: antibiotic_resistance def: "The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr." [PMID:28663118] is_a: ARO:3000202 ! Cfr 23S ribosomal RNA methyltransferase synonym: "cfr(A) Group" EXACT [] [Term] id: ARO:3004608 name: EreD namespace: antibiotic_resistance def: "EreD is an erythromycin esterase protein." [PMID:26107936] is_a: ARO:3000320 ! macrolide esterase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Ere(D)" EXACT [] synonym: "EreD" EXACT CARD_Short_Name [] [Term] id: ARO:3004609 name: cfr(B) Group namespace: antibiotic_resistance def: "The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr." [PMID:28663118] is_a: ARO:3000202 ! Cfr 23S ribosomal RNA methyltransferase [Term] id: ARO:3004610 name: cfr(C) Group namespace: antibiotic_resistance def: "The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr." [PMID:28663118] is_a: ARO:3000202 ! Cfr 23S ribosomal RNA methyltransferase [Term] id: ARO:3004613 name: tet(47) namespace: antibiotic_resistance def: "A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics." [PMID:26097034] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(47)" EXACT CARD_Short_Name [] synonym: "tet47" EXACT [] [Term] id: ARO:3004615 name: ADC-11 namespace: antibiotic_resistance def: "ADC-11 is a class C beta-lactamase found in Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-11" EXACT CARD_Short_Name [] [Term] id: ARO:3004616 name: Mycoplasma genitalium 23S rRNA mutations confers resistance to fluoroquinolone and macrolide antibiotics namespace: antibiotic_resistance def: "Mycoplasma genitalium strain M6320 contains mutations that lead to resistance to fluoroquinolone and macrolide antibiotics." [PMID:18990060, PMID:22532861, PMID:23658265] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Mgen_23S_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004617 name: ADC-30 namespace: antibiotic_resistance def: "An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-30" EXACT CARD_Short_Name [] [Term] id: ARO:3004618 name: ADC-58 namespace: antibiotic_resistance def: "An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-58" EXACT CARD_Short_Name [] [Term] id: ARO:3004619 name: ADC-59 namespace: antibiotic_resistance def: "An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-59" EXACT CARD_Short_Name [] [Term] id: ARO:3004620 name: ADC-60 namespace: antibiotic_resistance def: "An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-60" EXACT CARD_Short_Name [] [Term] id: ARO:3004621 name: AAC(3)-IIe namespace: antibiotic_resistance def: "AAC(3)-IIe is a plasmid-encoded aminoglycoside acetyltransferase in E. coli." [PMID:20185552] is_a: ARO:3007385 ! AAC(3)-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IIe" EXACT CARD_Short_Name [] synonym: "aacC2e" EXACT [] [Term] id: ARO:3004622 name: QnrS10 namespace: antibiotic_resistance def: "QnrS10 is a plasmid-mediated quinolone resistance protein." [PMID:23648253] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS10" EXACT CARD_Short_Name [] [Term] id: ARO:3004623 name: AAC(3)-IId namespace: antibiotic_resistance def: "AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli." [PMID:20185552] is_a: ARO:3007385 ! AAC(3)-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IId" EXACT CARD_Short_Name [] synonym: "aacC2d" EXACT [] [Term] id: ARO:3004624 name: QnrS11 namespace: antibiotic_resistance def: "QnrS11 is a plasmid-mediated quinolone resistance protein." [PMID:22470007] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS11" EXACT CARD_Short_Name [] [Term] id: ARO:3004625 name: QnrS12 namespace: antibiotic_resistance def: "QnrS12 is a plasmid-mediated quinolone resistance protein." [PMID:29415140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS12" EXACT CARD_Short_Name [] [Term] id: ARO:3004626 name: Erm(49) namespace: antibiotic_resistance def: "Erm(49) is an rRNA methylase gene." [PMID:29500262, PMID:23882264] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "Erm(49)" EXACT CARD_Short_Name [] [Term] id: ARO:3004627 name: QnrS15 namespace: antibiotic_resistance def: "QnrS15 is a plasmid-mediated quinolone resistance protein." [PMID:29415140] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrS15" EXACT CARD_Short_Name [] [Term] id: ARO:3004628 name: AAC(2')-IIa namespace: antibiotic_resistance def: "AAC(2')-IIa is a kasugamycin 2' N-acetyltransferase protein found in Burkholderia glumae and Acidovorax avenae isolates." [PMID:22660700] is_a: ARO:3007394 ! AAC(2')-II relationship: confers_resistance_to_antibiotic ARO:3001296 ! kasugamycin synonym: "AAC(2')-IIa" EXACT CARD_Short_Name [] [Term] id: ARO:3004629 name: AAC(6')-Im namespace: antibiotic_resistance def: "AAC(6')-Im is an aminoglycoside acetyltransferase encoded by plasmids in E. coli, and E. faecium." [PMID:11557456] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Im" EXACT CARD_Short_Name [] [Term] id: ARO:3004630 name: Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin namespace: antibiotic_resistance def: "Mycoplasma genitalium exhibits multiple mutations in parC which confers resistance to Moxifloxacin." [PMID:19567408, PMID:29883482, PMID:23658265, PMID:15728924, PMID:20580532] is_a: ARO:3000619 ! fluoroquinolone resistant parC relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin synonym: "Mgen_parC_MXF" EXACT CARD_Short_Name [] [Term] id: ARO:3004631 name: Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones namespace: antibiotic_resistance def: "Mycoplasma Genitalium GyrA mutations confers resistance to fluoroquinolones such as Moxifloxacin." [PMID:23658265, PMID:14506049, PMID:15728924, PMID:29883482] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin synonym: "Mgen_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3004632 name: ADC-62 namespace: antibiotic_resistance def: "A class ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-62" EXACT CARD_Short_Name [] [Term] id: ARO:3004633 name: ADC-67 namespace: antibiotic_resistance def: "A class C beta-lactamase and cephalosporinase from Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-67" EXACT CARD_Short_Name [] [Term] id: ARO:3004634 name: ADC-73 namespace: antibiotic_resistance def: "A class C ADC beta-lactamase and cephalosporinase found in Acinetobacter baumannii." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-73" EXACT CARD_Short_Name [] [Term] id: ARO:3004635 name: AAC(6')-Il namespace: antibiotic_resistance def: "AAC(6')-Il is an aminoglycoside acetyltransferase encoded by plasmids and integrons in Enterobacter cloaecae and Klebsiella aerogenes." [PMID:7793874] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Il" EXACT CARD_Short_Name [] synonym: "aacA7" EXACT [] [Term] id: ARO:3004636 name: qnrE1 namespace: antibiotic_resistance def: "qnrE1 is a member of the qnrE family of plasmid-borne (fluoro)quinolone-resistance genes, with chromosomal origins from Enterobacter spp." [PMID:28193666] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "qnrE1" EXACT CARD_Short_Name [] [Term] id: ARO:3004637 name: qnrE2 namespace: antibiotic_resistance def: "qnrE2 is a qnrE-member of plasmid-borne (fluoro)quinolone-resistance genes." [PMID:34097486] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "qnrE2" EXACT CARD_Short_Name [] [Term] id: ARO:3004638 name: AAC(6')-I-48 namespace: antibiotic_resistance def: "AAC(6')-I-48 (AAC(6')-Iag) is an aminoglycoside acetyltransferase encoded by integrons in Pseudomonas aeruginosa." [PMID:23950962] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-I-48" EXACT CARD_Short_Name [] synonym: "AAC(6')-Iag" EXACT [] synonym: "aacA48" EXACT [] [Term] id: ARO:3004639 name: Corynebacterium striatum tetA namespace: antibiotic_resistance def: "The tetAB genes of the Corynebacterium striatum R-plasmid encode an ABC transporter and confer tetracycline, oxytetracycline, and oxalic resistance." [PMID:10732668] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000056 ! oxacillin relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "Cstr_tetA" EXACT CARD_Short_Name [] [Term] id: ARO:3004640 name: dfrA15b namespace: antibiotic_resistance def: "A dihydrofolate reductase found in Salmonella Enterica." [PMID:15761062] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA15b" EXACT CARD_Short_Name [] [Term] id: ARO:3004641 name: AAC(6')-I-43 namespace: antibiotic_resistance def: "AAC(6')-I-43 (aacA43) is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae." [PMID:21422220] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-I-43" EXACT CARD_Short_Name [] [Term] id: ARO:3004642 name: dfrA3b namespace: antibiotic_resistance def: "A dihydrofolate reductase that confers resistance to trimethoprim." [PMID:14638506] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA3b" EXACT CARD_Short_Name [] [Term] id: ARO:3004643 name: Erm(K) namespace: antibiotic_resistance def: "A 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K) [Alkalihalobacillus halodurans]." [PMID:1713206] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Erm(K)" EXACT CARD_Short_Name [] [Term] id: ARO:3004644 name: dfrA6 from Proteus mirabilis namespace: antibiotic_resistance def: "dfrA6 is a dihydrofolate reductase that confers resistance to trimethoprim. Found in Proteus mirabilis." [PMID:1941991] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "Pmir_dfrA6" EXACT CARD_Short_Name [] [Term] id: ARO:3004645 name: dfrI namespace: antibiotic_resistance def: "dfrI is a dihydrofolate reductase that is resistant to trimethoprim." [PMID:17375195] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrI" EXACT CARD_Short_Name [] [Term] id: ARO:3004647 name: AQU-2 namespace: antibiotic_resistance def: "AQU-2 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from Aeromonas." [] is_a: ARO:3002992 ! AQU beta-lactamase synonym: "AQU-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004648 name: AQU-3 namespace: antibiotic_resistance def: "AQU-3 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from." [] is_a: ARO:3002992 ! AQU beta-lactamase synonym: "AQU-3" EXACT CARD_Short_Name [] [Term] id: ARO:3004649 name: cfr(B) namespace: antibiotic_resistance def: "cfr(B) has been observed in mobile genetic elements in E. faecium and Clostridioides difficile and confers resistance to linezolid, clindamycin, erythromycin, chloramphenicol, and retapamulin." [PMID:26248384] is_a: ARO:3004609 ! cfr(B) Group relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cfr(B)" EXACT CARD_Short_Name [] [Term] id: ARO:3004650 name: tet(U) namespace: antibiotic_resistance def: "Initially reported as a tetracycline-resistant determinant encoded on the plasmid pKQ10 in Enterococcus faecium, tet(U) has since been determined to be a misannotation of a gene product not involved in tetracycline resistance." [PMID:8700968, PMID:22491689] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump synonym: "tetU" EXACT [] [Term] id: ARO:3004651 name: lin namespace: antibiotic_resistance def: "Listeria monocytogenes EGD-e lin gene for lincomycin resistance ABC-F type ribosomal protection protein, complete CDS." [PMID:32615922] is_a: ARO:3000221 ! lincosamide nucleotidyltransferase (LNU) relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin synonym: "lin" EXACT CARD_Short_Name [] [Term] id: ARO:3004652 name: Erm(O)-lrm namespace: antibiotic_resistance def: "ErmO (gene lrm) lincomycin resistance methylase [Streptomyces lividans]." [PMID:1761231] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3000145 ! tylosin synonym: "Erm(O)-lrm" EXACT CARD_Short_Name [] synonym: "lrm" EXACT [] [Term] id: ARO:3004653 name: tetR(G) namespace: antibiotic_resistance def: "Class G tetracycline resistance determinant from Vibrio anguillarum." [PMID:1479961] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tetR(G)" EXACT CARD_Short_Name [] [Term] id: ARO:3004654 name: Clostridioides difficile 23S rRNA with mutation conferring resistance to erythromycin and clindamycin namespace: antibiotic_resistance def: "SNP causing high-level ERY resistance and low-level CLI resistance." [PMID:17509804] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "Cdif_23S_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3004655 name: nimB namespace: antibiotic_resistance def: "nimB is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment." [PMID:8067736, PMID:10970359] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimB" EXACT CARD_Short_Name [] [Term] id: ARO:3004656 name: catII from Escherichia coli K-12 namespace: antibiotic_resistance def: "catII is a chloramphenicol acetyltransferase. This particular catII is found in E.coli K-12. Confers resistance to chloramphenicol." [PMID:2268278] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "Ecol_catII" EXACT CARD_Short_Name [] [Term] id: ARO:3004657 name: catA4 namespace: antibiotic_resistance def: "catA4 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol." [PMID:3900035] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "catA4" EXACT CARD_Short_Name [] [Term] id: ARO:3004658 name: catA8 namespace: antibiotic_resistance def: "catA8 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol." [PMID:9349809, PMID:11257023, PMID:11735367] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "catA8" EXACT CARD_Short_Name [] [Term] id: ARO:3004659 name: Mef(En2) namespace: antibiotic_resistance def: "NBU2-encoded resistance gene. An MefE homolog in Bacteroides species. Macrolide efflux MFS transporter." [PMID:10852890] is_a: ARO:3000747 ! mef relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin synonym: "Mef(En2)" EXACT CARD_Short_Name [] [Term] id: ARO:3004660 name: catB11 namespace: antibiotic_resistance def: "catB11 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol." [PMID:19416365] is_a: ARO:3000122 ! chloramphenicol acetyltransferase (CAT) relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "catB11" EXACT CARD_Short_Name [] [Term] id: ARO:3004661 name: Staphylococcus aureus FosB namespace: antibiotic_resistance def: "The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein." [PMID:11244082] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "Saur_FosB" EXACT CARD_Short_Name [] [Term] id: ARO:3004662 name: MCR-3.3 namespace: antibiotic_resistance def: "MCR-3.3 is a colistin resistance gene variant in the chromosome of an Aeromonas veronii. Conferred polymyxin resistance in both E. Coli and Aeromonas salmonicida." [PMID:28848017] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.3" EXACT CARD_Short_Name [] [Term] id: ARO:3004663 name: FusF namespace: antibiotic_resistance def: "A fusidic acid resistance determinant in Staphylococcus cohnii. This protein behaves akin to FusB as it is a FusB-type protein. It mediates dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid." [PMID:25313205] is_a: ARO:3005086 ! Target protecting FusB-type protein conferring resistance to Fusidic acid relationship: confers_resistance_to_antibiotic ARO:3000759 ! fusidic acid synonym: "FusF" EXACT CARD_Short_Name [] [Term] id: ARO:3004665 name: cmlA8 namespace: antibiotic_resistance def: "cmlA8 is a plasmid that confers resistance to chloramphenicol." [PMID:19107398] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "cmlA8" EXACT CARD_Short_Name [] [Term] id: ARO:3004666 name: pexA namespace: antibiotic_resistance def: "pexA is a florfenicol and chloramphenicol resistance gene discovered in Alaskan soil." [PMID:20543056] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol synonym: "pexA" EXACT CARD_Short_Name [] [Term] id: ARO:3004667 name: Staphylococcus aureus norA namespace: antibiotic_resistance def: "NorA gene cloned from Staphylococcus aureus conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus and Escherichia coli. Had low or no resistance at all to hydrophobic ones such as nalidixic acid, oxolinic acid, and sparfloxacin in S. aureus and Escherichia coli." [PMID:2174864] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000023 ! enoxacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin synonym: "Saur_norA" EXACT CARD_Short_Name [] [Term] id: ARO:3004668 name: QnrAS namespace: antibiotic_resistance def: "Located on the chromosome of Aliivibrio salmonicida. Provides low-level resistance to quinolones." [PMID:20947314] is_a: ARO:3000419 ! quinolone resistance protein (qnr) synonym: "QnrAS" EXACT CARD_Short_Name [] [Term] id: ARO:3004669 name: emtA namespace: antibiotic_resistance def: "A rRNA methyltransferase conferring high-level evernimicin resistance." [PMID:11580839] is_a: ARO:3001298 ! non-erm 23S ribosomal RNA methyltransferase (G748) relationship: confers_resistance_to_antibiotic ARO:3007167 ! evernimicin synonym: "emtA" EXACT CARD_Short_Name [] [Term] id: ARO:3004670 name: FosB1 namespace: antibiotic_resistance def: "Subtype of FosB, fosfomycin resistant. S.aureus SA1129 carried a FosB1 identical to S. haemolyticus." [PMID:27144405] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosB1" EXACT CARD_Short_Name [] [Term] id: ARO:3004671 name: FosB4 namespace: antibiotic_resistance def: "Fosfomycin resistance gene. Shares a high homology with FosB1 and FosB3." [PMID:27144405] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosB4" EXACT CARD_Short_Name [] [Term] id: ARO:3004672 name: FosB5 namespace: antibiotic_resistance def: "Fosfomycin resistance gene. High homology with FosB1 and FosB3." [PMID:27144405] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosB5" EXACT CARD_Short_Name [] [Term] id: ARO:3004673 name: FosB6 namespace: antibiotic_resistance def: "Fosfomycin resistance gene. High homology with FosB1 and FosB3." [PMID:27144405] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosB6" EXACT CARD_Short_Name [] [Term] id: ARO:3004674 name: FosD namespace: antibiotic_resistance def: "A fosfomycin resistance gene." [PMID:18539327] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosD" EXACT CARD_Short_Name [] [Term] id: ARO:3004675 name: aphA15 namespace: antibiotic_resistance def: "Expression of cloned aphA15 gene in Escherichia coli reduced the susceptibility to kanamycin and neomycin, as well as to amikacin, netilmicin, and streptomycin." [PMID:11257042] is_a: ARO:3007406 ! APH(3')-I relationship: confers_resistance_to_antibiotic ARO:0000005 ! neomycin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "aphA15" EXACT CARD_Short_Name [] [Term] id: ARO:3004677 name: rmtD2 namespace: antibiotic_resistance def: "The first allele of a 16S rRNA methyltransferase gene, rmtD2, confers a high resistance to all clinically available aminoglycosides." [PMID:21078935] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "rmtD2" EXACT CARD_Short_Name [] [Term] id: ARO:3004678 name: rmtE namespace: antibiotic_resistance def: "Aminoglycoside-resistance gene." [PMID:20368404] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "rmtE" EXACT CARD_Short_Name [] [Term] id: ARO:3004679 name: rmtE2 namespace: antibiotic_resistance def: "A 16S rRNA mathyltransferase gene with a single nucleotide mutation compared to rmtE." [PMID:26392485] is_a: ARO:3004271 ! 16S rRNA methyltransferase (G1405) relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "rmtE2" EXACT CARD_Short_Name [] [Term] id: ARO:3004680 name: APH(3')-VIIIa namespace: antibiotic_resistance def: "APH(3')-VIIIa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Streptomyces rimosus." [PMID:23240563] is_a: ARO:3000126 ! APH(3') relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "APH(3')-VIIIa" EXACT CARD_Short_Name [] [Term] id: ARO:3004681 name: Clostridioides difficile rpoC with mutation conferring resistance to vancomycin namespace: antibiotic_resistance def: "Point mutations in the rpoC region of Clostridioides difficile which confer resistance to vancomycin." [PMID:23887866] is_a: ARO:3004725 ! vancomycin-resistant beta prime subunit of RNA polymerase (rpoC) relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin synonym: "Cdif_rpoC_VAN" EXACT CARD_Short_Name [] [Term] id: ARO:3004682 name: aadA27 namespace: antibiotic_resistance def: "Small mobilizable plasmid pALWED1.8 containing a novel variant of the streptomycin/spectinomycin resistance gene." [PMID:26896789] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA27" EXACT CARD_Short_Name [] [Term] id: ARO:3004683 name: aadS namespace: antibiotic_resistance def: "A novel Tn4551 streptomycin-resistance gene that was phenotypically silent in wild-type Bacteroides; expression could be activated by a trans-acting chromosomal mutation." [PMID:1328814] is_a: ARO:3007399 ! ANT(6)-I relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadS" EXACT CARD_Short_Name [] [Term] id: ARO:3004684 name: MCR-9.1 namespace: antibiotic_resistance def: "A mobilized and plasmid-mediated colistin resistance gene and phosphoethanolamine transferase identified from a Salmonella enterica isolate." [PMID:31064835] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-9" EXACT [] synonym: "MCR-9.1" EXACT CARD_Short_Name [] [Term] id: ARO:3004685 name: MCR-1.5 namespace: antibiotic_resistance def: "A plasmid-mediated MCR-1 variant identified from polyclonal clinical Escherichia coli." [PMID:28678874] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.5" EXACT CARD_Short_Name [] [Term] id: ARO:3004686 name: MCR-1.7 namespace: antibiotic_resistance def: "A plasmid-mediated MCR-1 variant identified from Escherichia coli." [PMID:29118748] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.7" EXACT CARD_Short_Name [] [Term] id: ARO:3004687 name: MCR-1.8 namespace: antibiotic_resistance def: "An unpublished MCR-1 variant included in NCBI and indicated by Partridge et al. 2018." [PMID:30053115] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.8" EXACT CARD_Short_Name [] [Term] id: ARO:3004688 name: MCR-1.11 namespace: antibiotic_resistance def: "A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli as conferring resistance to colistin antibiotics." [PMID:30053115] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.11" EXACT CARD_Short_Name [] [Term] id: ARO:3004689 name: MCR-1.12 namespace: antibiotic_resistance def: "A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli and conferring resistance to colistin antibiotics." [PMID:30053115, PMID:29052266] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.12" EXACT CARD_Short_Name [] [Term] id: ARO:3004690 name: MCR-1.13 namespace: antibiotic_resistance def: "A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli." [PMID:30053115] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.13" EXACT CARD_Short_Name [] [Term] id: ARO:3004691 name: MCR-3.4 namespace: antibiotic_resistance def: "A plasmid-mediated MCR-3.1 variant." [PMID:30053115] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.4" EXACT CARD_Short_Name [] [Term] id: ARO:3004692 name: aadA10 namespace: antibiotic_resistance def: "aadA10 is a aminoglycoside nucleotidyltransferase gene encoded by plasmids in P. aeruginosa." [PMID:12121911] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA10" EXACT CARD_Short_Name [] [Term] id: ARO:3004693 name: MCR-3.12 namespace: antibiotic_resistance def: "A plasmid-mediated phosphoethanolamine transferase and MCR-3 variant conferring resistance to colistin antibiotics." [PMID:30053115, PMID:29712655] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004139 ! MCR-3.1 synonym: "MCR-3.12" EXACT CARD_Short_Name [] [Term] id: ARO:3004694 name: MCR-4.2 namespace: antibiotic_resistance def: "A plasmid-mediated MCR-4 variant which confers resistance to colistin antibiotics." [PMID:30053115, PMID:29635007] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004325 ! MCR-4.1 synonym: "MCR-4.2" EXACT CARD_Short_Name [] [Term] id: ARO:3004695 name: MCR-4.3 namespace: antibiotic_resistance def: "A plasmid-mediated MCR-4 variant and colistin resistance gene from clinical Enterobacteriaceae." [PMID:30053115, PMID:29237785] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004325 ! MCR-4.1 synonym: "MCR-4.3" EXACT CARD_Short_Name [] [Term] id: ARO:3004696 name: MCR-4.4 namespace: antibiotic_resistance def: "A plasmid-mediated MCR-4 variant and colistin resistance gene." [PMID:30053115, PMID:29635007] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004325 ! MCR-4.1 synonym: "MCR-4.4" EXACT CARD_Short_Name [] [Term] id: ARO:3004697 name: MCR-4.5 namespace: antibiotic_resistance def: "A plasmid-mediated MCR-4 variant and colistin resistance gene." [PMID:30053115, PMID:29635007] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004325 ! MCR-4.1 synonym: "MCR-4.5" EXACT CARD_Short_Name [] [Term] id: ARO:3004698 name: MCR-5.2 namespace: antibiotic_resistance def: "A plasmid-mediated MCR-5 variant from Escheichia coli which confers resistance to colistin antibiotics." [PMID:30053115, PMID:29444245] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3004332 ! MCR-5.1 synonym: "MCR-5.2" EXACT CARD_Short_Name [] [Term] id: ARO:3004699 name: sta namespace: antibiotic_resistance def: "Streptothricin acetyltransferase gene (STAT gene) that confers streptothricin resistance on Escherichia coli and Bacillus subtilis." [PMID:3106324] is_a: ARO:3000869 ! streptothricin acetyltransferase (SAT) relationship: confers_resistance_to_antibiotic ARO:0000012 ! streptothricin synonym: "sta" EXACT CARD_Short_Name [] [Term] id: ARO:3004700 name: mutation in resistance determinant namespace: antibiotic_resistance def: "Mutation in a resistance determinant rendering it non-functional." [] is_a: ARO:3004524 ! strain type [Term] id: ARO:3004701 name: ceftazidime-cloxacillin namespace: antibiotic_resistance def: "An antibiotic cocktail containing beta-lactam penam antibiotic cloxacillin and the cephalosporin ceftazidime." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000011 ! cloxacillin relationship: has_part ARO:0000060 ! ceftazidime [Term] id: ARO:3004702 name: cefepime-cloxacillin namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephalosporin cefepime and the penicillin cloxacillin." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000011 ! cloxacillin relationship: has_part ARO:0000059 ! cefepime [Term] id: ARO:3004703 name: imipenem-cloxacillin namespace: antibiotic_resistance def: "An antibiotic cocktail containing beta-lactam penam antibiotic cloxacillin and the beta-lactam carbapenam antibiotic imipenam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000011 ! cloxacillin relationship: has_part ARO:3000170 ! imipenem [Term] id: ARO:3004704 name: aadA8b namespace: antibiotic_resistance def: "aadA8b is an aminoglycoside nucleotidyltransferase gene encoded by plasmids in E. coli; can be created by a recombination event between aadA1 and aadA2." [PMID:16291869] is_a: ARO:3000232 ! ANT(3'')-Ia relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "aadA8b" EXACT CARD_Short_Name [] [Term] id: ARO:3004705 name: ceftazidime-clavulanic acid namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephalosporin antibiotic ceftazidime and the beta-lactamase inhibitor clavulanic acid." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000060 ! ceftazidime relationship: has_part ARO:0000079 ! clavulanic acid synonym: "ceftazidime-clavulanate" EXACT [] xref: pubchem.compound:9575352 [Term] id: ARO:3004706 name: mutation in resistance determinant with plasmid harbouring resistance determinant namespace: antibiotic_resistance def: "Experimental protocol where there is a mutation of resistance determinant and the transformation of a plasmid harbouring resistance determinant into the same strain." [] is_a: ARO:3004524 ! strain type [Term] id: ARO:3004707 name: cefoxitin-clavulanate namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor clavulanate." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000008 ! cefoxitin relationship: has_part ARO:0000079 ! clavulanic acid [Term] id: ARO:3004708 name: cefoxitin-sulbactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor sulbactam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000008 ! cefoxitin relationship: has_part ARO:3000587 ! sulbactam [Term] id: ARO:3004709 name: cefoxitin-tazobactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor tazobactam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000008 ! cefoxitin relationship: has_part ARO:0000077 ! tazobactam [Term] id: ARO:3004710 name: cefotaxime-clavulanic acid namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephalosporin antibiotic cefotaxime and the beta-lactamase inhibitor clavulanic acid." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000079 ! clavulanic acid relationship: has_part ARO:3000645 ! cefotaxime synonym: "cefotaxime-clavulante" EXACT [] [Term] id: ARO:3004711 name: cefotaxime-tazobactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephalosporin antibiotic cefotaxime and the beta-lactamase inhibitor Tazobactam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000077 ! tazobactam relationship: has_part ARO:3000645 ! cefotaxime [Term] id: ARO:3004712 name: ceftazidime-tazobactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephalosporin antibiotic ceftazidime and the beta-lactamase inhibitor tazobactam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000060 ! ceftazidime relationship: has_part ARO:0000077 ! tazobactam [Term] id: ARO:3004713 name: aztreonam-clavulanate namespace: antibiotic_resistance def: "An antibiotic cocktail containing the beta-lactam antibiotic aztreonam and the conjugate base of the beta-lactamase inhibitor clavulanic acid (clavulanate)." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000079 ! clavulanic acid relationship: has_part ARO:3000550 ! aztreonam synonym: "aztreonam-clavulanic acid" EXACT [] [Term] id: ARO:3004714 name: aztreonam-tazobactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the beta-lactam antibiotic aztreonam and the beta-lactamase inhibitor tazobactam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000077 ! tazobactam relationship: has_part ARO:3000550 ! aztreonam [Term] id: ARO:3004715 name: vga(E) Staphylococcus cohnii namespace: antibiotic_resistance def: "vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci." [PMID:24324222] is_a: ARO:3000113 ! vga-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin relationship: confers_resistance_to_antibiotic ARO:3001315 ! valnemulin synonym: "Scoh_vga(E)" EXACT CARD_Short_Name [] [Term] id: ARO:3004716 name: Vanillobiocin namespace: antibiotic_resistance def: "Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid." [PMID:15152806] is_a: ARO:3000103 ! aminocoumarin antibiotic [Term] id: ARO:3004717 name: Isovanillobiocin namespace: antibiotic_resistance def: "Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. different from vanillobiocin by the [psition of the pyrrole unit attached to the sugar moiety of the antibiotic." [PMID:15152806] is_a: ARO:3000103 ! aminocoumarin antibiotic [Term] id: ARO:3004718 name: Declovanillobiocin namespace: antibiotic_resistance def: "Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. Declovanillobiocin lacks the chlorine atom at the aminocoumarin ring compared to vanillobiocin." [PMID:15152806] is_a: ARO:3000103 ! aminocoumarin antibiotic [Term] id: ARO:3004719 name: tet(X3) namespace: antibiotic_resistance def: "A tetracyline resistance gene located on an approximately 300-kb plasmid, designated p47AB. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid." [PMID:31133751] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(X3)" EXACT CARD_Short_Name [] synonym: "tetX3" EXACT [] [Term] id: ARO:3004720 name: tet(X4) namespace: antibiotic_resistance def: "A tetracyline resistance gene located on an approximately 180-kb plasmid, designated p47EC. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid." [PMID:31133751] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(X4)" EXACT CARD_Short_Name [] synonym: "tetX4" EXACT [] [Term] id: ARO:3004721 name: Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide namespace: antibiotic_resistance def: "RpsA, the 30S ribosomal protein S1 of Mycobacterium tuberculosis, is involved in trans-translation and is targeted by pyrazinonic acid, the active form of the antibiotic pyrazinamide, which disrupts the initiation of mRNA translation. Mutations in the amino acid sequence of rpsA can confer resistance to pyrazinamide maintaining rpsA function." [PMID:29921403, PMID:30402208, PMID:30858213, PMID:31097767] is_a: ARO:3004722 ! pyrazinamide resistant rpsA relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_rpsA_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004722 name: pyrazinamide resistant rpsA namespace: antibiotic_resistance def: "The 30S ribosomal protein S1 of Mycobacterium tuberculosis is required for mRNA translation initiation, playing a particular role in trans-translation. Mutations to rpsA prevent pyrazinoic acid, the active form of pyrazinamide catalyzed by pncA, from targeting RpsA to inhibit translation." [PMID:29921403, PMID:21835980] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic synonym: "Ribosomal protein S1" EXACT [] [Term] id: ARO:3004723 name: gradient plate method namespace: antibiotic_resistance def: "A method to determine microbial susceptibility to antibiotics in which test bacteria is inoculated onto an agar plate that contains a concentration gradient of antibiotic. The minimum inhibitory concentration of antibiotic is assessed." [PMID:12999676] is_a: ARO:3004388 ! in-vitro microbial susceptibility test [Term] id: ARO:3004724 name: ceftolozane-tazobactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the cephalosporin antibiotic ceftolozane and the beta-lactamase inhibitor tazobactam." [] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000077 ! tazobactam relationship: has_part ARO:3003927 ! ceftolozane [Term] id: ARO:3004725 name: vancomycin-resistant beta prime subunit of RNA polymerase (rpoC) namespace: antibiotic_resistance def: "Point mutations in rpoC, an RNA polymerase subunit, which confer resistance to vancomycin." [] is_a: ARO:3003289 ! antibiotic resistant rpoC relationship: confers_resistance_to_drug_class ARO:3000081 ! glycopeptide antibiotic [Term] id: ARO:3004726 name: cefpirome namespace: antibiotic_resistance def: "Cefpirome is a fourth generation cephalosporin with activity against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci and viridans group streptococci, and in vitro activity towards Streptococcus pneumoniae." [PMID:9211085] is_a: ARO:0000032 ! cephalosporin xref: pubchem.compound:5479539 [Term] id: ARO:3004727 name: cefsulodin namespace: antibiotic_resistance def: "Cefsulodin is a third generation cephalosporin with with activity against Pseudomonas spp., but little activity against other Gram-negative bacteria." [PMID:119787] is_a: ARO:0000032 ! cephalosporin xref: pubchem.compound:5284530 [Term] id: ARO:3004728 name: carumonam namespace: antibiotic_resistance def: "Carumonam is a monobactam antibiotic. It has activity towards Gram-negative bacteria with negligible activity towards Gram-postitive bacteria." [PMID:4073864] is_a: ARO:0000004 ! monobactam xref: pubchem.compound:6540466 [Term] id: ARO:3004729 name: LYS228 namespace: antibiotic_resistance def: "A monobactam with potent activity against Enterobacteriaceae. Stable to metallo-B-lactamases and serine carbapenemases resulting in potency against the majority of extended-spectrum B-lactamase-producing and carbapenem-resistant Enterobacteriaceae strains tested." [PMID:30038040] is_a: ARO:0000004 ! monobactam xref: pubchem.compound:118380292 [Term] id: ARO:3004730 name: tva(A) namespace: antibiotic_resistance def: "A pleuromutilin resistance gene encoding a predicted ABC-F transporter. The presence of inhibitory or sub-inhibitory concentrations of tiamulin showed that tva(A) confers reduced pleuromutilin susceptibility that does not lead to clinical resistance but facilitates the development of higher-level resistance via mutations in genes encoding ribosome-associated functions." [PMID:29971045] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:3001317 ! pleuromutilin synonym: "tva(A)" EXACT CARD_Short_Name [] [Term] id: ARO:3004731 name: Zabofloxacin namespace: antibiotic_resistance def: "A fluoroquinolone with potent activity against Gram-positive pathogens. Showed the most potent in vitro and in vivo activities against drug-resistant Streptococcus pneumoniae. One of the most potent antibacterial agent against penicillin-resistant S. pneumoniae in a murine systemic infection model." [PMID:27869677, PMID:16873394] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:54556623 [Term] id: ARO:3004732 name: Finafloxacin namespace: antibiotic_resistance def: "An 8-cyano-substituted fluoroquinolone with increased antibacterial activity in acidic conditions in contrast to other fluoroquinolones which demonstrate reduced activity in lower pH. Finafloxacin showed increased bactericidal activity at pH 5 in comparison to pH 7 and ciprofloxacin at pH 5 in vitro." [PMID:21596526, PMID:28438936] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:11567473 [Term] id: ARO:3004733 name: Nemonoxacin namespace: antibiotic_resistance def: "A C-8-methoxy non-fluorinated quinolone exhibiting potent antibacterial activities against Gram-positive, including MRSA and fluoroquinolone-resistant MRSA, Gram-negative, and atypical pathogens, especially methicillin-resistant Staphylococcus aureus." [PMID:22650326, PMID:25529577] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:11993740 [Term] id: ARO:3004734 name: ARL-1 namespace: antibiotic_resistance def: "ARL-1 is a beta-lactamase gene found in Staphylococcus Arlettae." [PMID:28497118] is_a: ARO:3004742 ! ARL Beta-lactamase synonym: "ARL-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004735 name: ARL-2 namespace: antibiotic_resistance def: "ARL-2 is a beta-lactamase gene found in Staphylococcus Arlettae." [PMID:28497118] is_a: ARO:3004742 ! ARL Beta-lactamase synonym: "ARL-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004736 name: ARL-3 namespace: antibiotic_resistance def: "ARL-3 is a beta-lactamase gene found in Staphylococcus arlettae." [PMID:28497118] is_a: ARO:3004742 ! ARL Beta-lactamase synonym: "ARL-3" EXACT CARD_Short_Name [] [Term] id: ARO:3004737 name: ARL-4 namespace: antibiotic_resistance def: "ARL-4 is a beta-lactamase gene found in Staphylococcus arlettae." [PMID:28497118] is_a: ARO:3004742 ! ARL Beta-lactamase synonym: "ARL-4" EXACT CARD_Short_Name [] [Term] id: ARO:3004738 name: ARL-5 namespace: antibiotic_resistance def: "ARL-5 is a beta-lactamase gene found in Staphylococcus arlettae." [PMID:28497118] is_a: ARO:3004742 ! ARL Beta-lactamase synonym: "ARL-5" EXACT CARD_Short_Name [] [Term] id: ARO:3004739 name: ARL-6 namespace: antibiotic_resistance def: "ARL-6 is a beta-lactamase gene found in Staphylococcus arlettae." [PMID:28497118] is_a: ARO:3004742 ! ARL Beta-lactamase synonym: "ARL-6" EXACT CARD_Short_Name [] [Term] id: ARO:3004740 name: AST-1 namespace: antibiotic_resistance def: "AST-1 is a broad-spectrum beta-lactamase gene found in Nocardia asteroides." [PMID:11181374] is_a: ARO:3004741 ! AST Beta-lactamase synonym: "AST-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004741 name: AST Beta-lactamase namespace: antibiotic_resistance def: "A family of beta-lactamase known for their broad spectrum resistance profile." [PMID:11181374] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004742 name: ARL Beta-lactamase namespace: antibiotic_resistance def: "ARL beta-lactamase is an AMR Gene Family associated with Staphylococcus arlettae." [PMID:28497118] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004745 name: MIR-23 namespace: antibiotic_resistance def: "MIR-23, originally described as AZECL-25, is a class C beta-lactamase that is found in Enterobacter cloacae." [PMID:25022578] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "AZECL-25" EXACT [] synonym: "MIR-23" EXACT CARD_Short_Name [] [Term] id: ARO:3004746 name: BAT Beta-lactamase namespace: antibiotic_resistance def: "BAT is a class D beta-lactamase." [PMID:21464989] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004747 name: BAT-1 namespace: antibiotic_resistance def: "BAT-1 is a class D beta-lactamase found in Bacillus atrophaeus." [PMID:21464989, PMID:22843588] is_a: ARO:3004746 ! BAT Beta-lactamase synonym: "BAT-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004748 name: BCL Beta-lactamase namespace: antibiotic_resistance def: "BCL beta-lactamase is a class A beta-lactamase." [PMID:17846134, PMID:12654668] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004749 name: BCL-1 namespace: antibiotic_resistance def: "BCL-1 is a class A beta-lactamase found in Alkalihalobacillus clausii." [PMID:12654668, PMID:17846134] is_a: ARO:3004748 ! BCL Beta-lactamase synonym: "BCL-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004750 name: BES Beta-lactamase namespace: antibiotic_resistance def: "BES beta-lactamase is a class A beta-lactamase family." [PMID:11036023] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004751 name: BES-1 namespace: antibiotic_resistance def: "BES-1 is a class A beta-lactamase that is found in Serratia marcescens." [PMID:11036023] is_a: ARO:3004750 ! BES Beta-lactamase synonym: "BES-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004752 name: BIC Beta-lactamase namespace: antibiotic_resistance def: "BIC is a class A beta-lactamase conferring resistance to carbapenem." [PMID:19901091] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004753 name: BIC-1 namespace: antibiotic_resistance def: "BIC-1 is a beta-lactamase conferring resistance to carbapenems that is found in Pseudomonas fluorescens." [PMID:19901091] is_a: ARO:3004752 ! BIC Beta-lactamase synonym: "BIC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004754 name: BIL Beta-lactamase namespace: antibiotic_resistance def: "BIL beta-lactamase is plasmid-borne and is a class C beta-lactamase." [PMID:8067761] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004755 name: BIL-1 namespace: antibiotic_resistance def: "BIL-1 is a plasmid-borne beta-lactamase that is also a class C beta-lactamase." [PMID:8067761] is_a: ARO:3004754 ! BIL Beta-lactamase synonym: "BIL-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004756 name: BKC Beta-lactamase namespace: antibiotic_resistance def: "BKC beta-lactamase is a class A beta-lactamase." [PMID:26055384] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3004757 name: BKC-1 namespace: antibiotic_resistance def: "BKC-1 is a beta-lactamase conferring resistance to carbapenem and is found in Brazilian Klebsiella." [PMID:26055384] is_a: ARO:3004756 ! BKC Beta-lactamase synonym: "BKC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004758 name: BPU Beta-lactamase namespace: antibiotic_resistance def: "BPU is a class D beta lactamase gene family." [PMID:23799069, PMID:23812891, PMID:17895969] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004759 name: BPU-1 namespace: antibiotic_resistance def: "BPU-1 is a class D beta-lactamase found in Bacillus pumilus." [PMID:29884123, PMID:23812891, PMID:17895969, PMID:23799069, PMID:27351589] is_a: ARO:3004758 ! BPU Beta-lactamase synonym: "BPU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004760 name: BRO Beta-lactamase namespace: antibiotic_resistance def: "BRO is a class A beta-lactamase that is found in M.catarrhalis." [PMID:8849261] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004761 name: BRO-1 namespace: antibiotic_resistance def: "BRO-1 is a class A beta-lactamase found in M.catarrhalis." [PMID:8849261] is_a: ARO:3004760 ! BRO Beta-lactamase synonym: "BRO-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004762 name: BRO-2 namespace: antibiotic_resistance def: "BRO-2 is a class A beta-lactamase found in M.catarrhalis." [PMID:8849261] is_a: ARO:3004760 ! BRO Beta-lactamase synonym: "BRO-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004763 name: CBP beta-lactamase namespace: antibiotic_resistance def: "CBP is a class A beta-lactamase family found in C. botulinum." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004764 name: CBP-1 namespace: antibiotic_resistance def: "CBP-1 is a class A beta-lactamase gene found in C. botulinum." [] is_a: ARO:3004763 ! CBP beta-lactamase synonym: "CBP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004765 name: CGA beta-lactamase namespace: antibiotic_resistance def: "CGA is a class A beta-lactamase family that is found in Chryseobacterium gleum." [PMID:11897576] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004766 name: CGA-1 namespace: antibiotic_resistance def: "CGA-1 is a class A beta-lactamase gene found in Chryseobacterium gleum." [PMID:11897576] is_a: ARO:3004765 ! CGA beta-lactamase synonym: "CGA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004767 name: CIA beta-lactamase namespace: antibiotic_resistance def: "CIA is a class A beta-lactamase gene family found in Chryseobacterium indologenes." [PMID:22083470] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004768 name: CIA-1 namespace: antibiotic_resistance def: "CIA-1 is a class A beta-lactamase gene found in Chryseobacterium indologenes." [PMID:22083470] is_a: ARO:3004767 ! CIA beta-lactamase synonym: "CIA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004769 name: CIA-2 namespace: antibiotic_resistance def: "CIA-2 is a class A beta-lactamase gene found in Chryseobacterium indologenes." [PMID:22083470] is_a: ARO:3004767 ! CIA beta-lactamase synonym: "CIA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004770 name: CIA-3 namespace: antibiotic_resistance def: "CIA-3 is a class A beta-lactamase gene found in Chryseobacterium indologenes." [PMID:22083470] is_a: ARO:3004767 ! CIA beta-lactamase synonym: "CIA-3" EXACT CARD_Short_Name [] [Term] id: ARO:3004771 name: CIA-4 namespace: antibiotic_resistance def: "CIA-4 is a class A beta-lactamase gene found in Chryseobacterium indologenes." [PMID:22083470] is_a: ARO:3004767 ! CIA beta-lactamase synonym: "CIA-4" EXACT CARD_Short_Name [] [Term] id: ARO:3004772 name: CKO beta-lactamase namespace: antibiotic_resistance def: "CKO is a class A beta-lactamase gene family found in Citrobacter koseri." [PMID:16445758] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004773 name: CKO-1 namespace: antibiotic_resistance def: "CKO-1 is a class A beta-lactamase gene found in Citrobacter koseri." [PMID:16445758] is_a: ARO:3004772 ! CKO beta-lactamase synonym: "CKO-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004774 name: CME beta-lactamase namespace: antibiotic_resistance def: "CME is a class A beta-lactamase gene family belonging to Chryseobacterium meningosepticum." [PMID:10471563] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004775 name: CME-1 namespace: antibiotic_resistance def: "CME-1 is a class A beta-lactamase gene belonging to Chryseobacterium meningosepticum." [PMID:10471563] is_a: ARO:3004774 ! CME beta-lactamase synonym: "CME-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004776 name: CMH beta-lactamase namespace: antibiotic_resistance def: "CMH is a class C beta-lactamase gene family belonging to Enterobacter cloacae." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004777 name: CMH-1 namespace: antibiotic_resistance def: "CMH-1 is a class C beta-lactamase gene found in Enterobacter cloacae." [] is_a: ARO:3004776 ! CMH beta-lactamase synonym: "CMH-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004778 name: CMY-135 namespace: antibiotic_resistance def: "CMY-135 is a class C beta-lactamase that confers resistance to cephamycin." [PMID:26126492] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-135" EXACT CARD_Short_Name [] [Term] id: ARO:3004779 name: DES beta-lactamase namespace: antibiotic_resistance def: "DES is a class A beta-lactamase gene family found in Desulfovibrio desulfuricans." [PMID:12234847] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004780 name: DES-1 namespace: antibiotic_resistance def: "DES-1 is a class A beta-lactamase gene found in Desulfovibrio desulfuricans." [PMID:12234847] is_a: ARO:3004779 ! DES beta-lactamase synonym: "DES-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004781 name: ERP beta-lactamase namespace: antibiotic_resistance def: "ERP is a class A beta-lactamase gene family found in Erwinia persicina." [PMID:12384342] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004782 name: ERP-1 namespace: antibiotic_resistance def: "ERP-1 is a class A beta-lactamase gene found in Erwinia persicina." [PMID:12384342] is_a: ARO:3004781 ! ERP beta-lactamase synonym: "ERP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004783 name: FAR beta-lactamase namespace: antibiotic_resistance def: "FAR is a class A extended spectrum beta-lactamase gene family found in Nocardia farcinica." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004784 name: FAR-1 namespace: antibiotic_resistance def: "FAR-1 is a class A beta-lactamase gene found in Nocardia farcinica." [] is_a: ARO:3004783 ! FAR beta-lactamase synonym: "FAR-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004785 name: FIM beta-lactamase namespace: antibiotic_resistance def: "FIM is a metallo-beta-lactamase gene family found in Pseudomonas aeruginosa." [PMID:23114762] is_a: ARO:3000004 ! class B (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3004786 name: FIM-1 namespace: antibiotic_resistance def: "FIM-1 is a metallo-beta-lactamase gene found in Pseudomonas aeruginosa from isolates in Italy." [PMID:23114762] is_a: ARO:3004785 ! FIM beta-lactamase synonym: "FIM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004787 name: FONA beta-lactamase namespace: antibiotic_resistance def: "FONA is a class A beta-lactamase gene family found in Serratia fonticola." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004788 name: FONA-1 namespace: antibiotic_resistance def: "FONA-1 is a class A beta-lactamase gene found in Serratia fonticola." [] is_a: ARO:3004787 ! FONA beta-lactamase synonym: "FONA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004789 name: FONA-2 namespace: antibiotic_resistance def: "FONA-2 is a class A beta-lactamase gene found in Serratia fonticola." [] is_a: ARO:3004787 ! FONA beta-lactamase synonym: "FONA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004790 name: FONA-3 namespace: antibiotic_resistance def: "FONA-3 is a class A beta-lactamase gene found in Serratia fonticola." [] is_a: ARO:3004787 ! FONA beta-lactamase synonym: "FONA-3" EXACT CARD_Short_Name [] [Term] id: ARO:3004791 name: FONA-4 namespace: antibiotic_resistance def: "FONA-4 is a class A beta-lactamase gene found in Serratia fonticola." [] is_a: ARO:3004787 ! FONA beta-lactamase synonym: "FONA-4" EXACT CARD_Short_Name [] [Term] id: ARO:3004792 name: FONA-5 namespace: antibiotic_resistance def: "FONA-5 is a class A beta-lactamase gene found in Serratia fonticola." [] is_a: ARO:3004787 ! FONA beta-lactamase synonym: "FONA-5" EXACT CARD_Short_Name [] [Term] id: ARO:3004793 name: FONA-6 namespace: antibiotic_resistance def: "FONA-6 is a class A beta-lactamase gene found in Serratia fonticola." [] is_a: ARO:3004787 ! FONA beta-lactamase synonym: "FONA-6" EXACT CARD_Short_Name [] [Term] id: ARO:3004794 name: FPH beta-lactamase namespace: antibiotic_resistance def: "FPH is a carbapenem-hydrolyzing class A beta-lactamase found in Francisella philomiragia." [PMID:25931589] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004795 name: FPH-1 namespace: antibiotic_resistance def: "FPH-1 is a carbapenem-hydrolyzing class A beta-lactamase gene found in Francisella philomiragia." [PMID:25931589] is_a: ARO:3004794 ! FPH beta-lactamase synonym: "FPH-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004796 name: FRI beta-lactamase namespace: antibiotic_resistance def: "FRI is a carbapenem-Hydrolyzing Class A beta-Lactamase from Enterobacter cloacae." [PMID:26392482] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004797 name: FRI-1 namespace: antibiotic_resistance def: "FRI-1 is a carbapenem-hydrolyzing Class A beta-lactamase found in Enterobacter cloacae." [PMID:26392482] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004798 name: FRI-2 namespace: antibiotic_resistance def: "FRI-2 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae." [PMID:30060114] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004799 name: FRI-3 namespace: antibiotic_resistance def: "FRI-3 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae." [] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-3" EXACT CARD_Short_Name [] [Term] id: ARO:3004800 name: FTU beta-lactamase namespace: antibiotic_resistance def: "FTU is a class A beta-lactamase gene family found in Francisella tularensis." [PMID:15640799] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004801 name: FTU-1 namespace: antibiotic_resistance def: "FTU-1 is a class A beta-lactamase gene found in Francisella tularensis. It causes Tularemia." [PMID:15640799, PMID:20140244] is_a: ARO:3004800 ! FTU beta-lactamase synonym: "FTU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004802 name: GOB-10 namespace: antibiotic_resistance def: "GOB-10 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum." [PMID:20571954] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-10" EXACT CARD_Short_Name [] [Term] id: ARO:3004803 name: GOB-11 namespace: antibiotic_resistance def: "GOB-11 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum." [PMID:20571954] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-11" EXACT CARD_Short_Name [] [Term] id: ARO:3004804 name: GOB-12 namespace: antibiotic_resistance def: "GOB-12 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:20571954] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-12" EXACT CARD_Short_Name [] [Term] id: ARO:3004805 name: GOB-13 namespace: antibiotic_resistance def: "GOB-13 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:20571954] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-13" EXACT CARD_Short_Name [] [Term] id: ARO:3004806 name: GOB-14 namespace: antibiotic_resistance def: "GOB-14 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-14" EXACT CARD_Short_Name [] [Term] id: ARO:3004807 name: GOB-15 namespace: antibiotic_resistance def: "GOB-15 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:20571954] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-15" EXACT CARD_Short_Name [] [Term] id: ARO:3004808 name: GOB-16 namespace: antibiotic_resistance def: "GOB-16 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-16" EXACT CARD_Short_Name [] [Term] id: ARO:3004809 name: GOB-2 namespace: antibiotic_resistance def: "GOB-2 is class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:10858348] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004810 name: GOB-3 namespace: antibiotic_resistance def: "GOB-3 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:10858348] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-3" EXACT CARD_Short_Name [] [Term] id: ARO:3004811 name: GOB-4 namespace: antibiotic_resistance def: "GOB-4 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:10858348] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-4" EXACT CARD_Short_Name [] [Term] id: ARO:3004812 name: GOB-5 namespace: antibiotic_resistance def: "GOB-5 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:10858348] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-5" EXACT CARD_Short_Name [] [Term] id: ARO:3004813 name: GOB-6 namespace: antibiotic_resistance def: "GOB-6 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:10858348] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-6" EXACT CARD_Short_Name [] [Term] id: ARO:3004814 name: GOB-7 namespace: antibiotic_resistance def: "GOB-7 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:10858348] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-7" EXACT CARD_Short_Name [] [Term] id: ARO:3004815 name: GOB-8 namespace: antibiotic_resistance def: "GOB-8 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:20571954] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-8" EXACT CARD_Short_Name [] [Term] id: ARO:3004816 name: GOB-9 namespace: antibiotic_resistance def: "GOB-9 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica." [PMID:20571954] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-9" EXACT CARD_Short_Name [] [Term] id: ARO:3004817 name: HERA-2 namespace: antibiotic_resistance def: "HERA-2 is a class A beta-lactamase found in Atlantibacter hermannii." [PMID:12878539] is_a: ARO:3004447 ! HERA beta-lactamase synonym: "HERA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004818 name: HERA-3 namespace: antibiotic_resistance def: "HERA-3 is a class A beta-lactamase found in Escherichia hermannii." [PMID:12878539] is_a: ARO:3004447 ! HERA beta-lactamase synonym: "HERA-3" EXACT CARD_Short_Name [] [Term] id: ARO:3004819 name: HERA-4 namespace: antibiotic_resistance def: "HERA-4 is a class A beta-lactamase found in Escherichia hermannii." [PMID:12878539] is_a: ARO:3004447 ! HERA beta-lactamase synonym: "HERA-4" EXACT CARD_Short_Name [] [Term] id: ARO:3004820 name: HERA-5 namespace: antibiotic_resistance def: "HERA-5 is a class A beta-lactamase found in Escherichia hermannii." [PMID:12878539] is_a: ARO:3004447 ! HERA beta-lactamase synonym: "HERA-5" EXACT CARD_Short_Name [] [Term] id: ARO:3004821 name: HERA-6 namespace: antibiotic_resistance def: "HERA-6 is a class A beta-lactamase found in Escherichia hermannii." [PMID:12878539] is_a: ARO:3004447 ! HERA beta-lactamase synonym: "HERA-6" EXACT CARD_Short_Name [] [Term] id: ARO:3004822 name: HERA-8 namespace: antibiotic_resistance def: "HERA-8 is a class A beta-lactamase found in Escherichia hermannii." [PMID:12878539] is_a: ARO:3004447 ! HERA beta-lactamase synonym: "HERA-8" EXACT CARD_Short_Name [] [Term] id: ARO:3004823 name: IMP-52 namespace: antibiotic_resistance def: "IMP-52 is a class B metallo-beta-lactamase found in Escherichia coli." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-52" EXACT CARD_Short_Name [] [Term] id: ARO:3004824 name: LAP beta-lactamase namespace: antibiotic_resistance def: "LAP is a Ambler Class A beta-lactamase gene family that confers resistance to beta-lactams." [PMID:16982792, PMID:17116662] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3004825 name: LAP-1 namespace: antibiotic_resistance def: "LAP-1 is an Ambler Class A beta-lactamase gene." [PMID:17116662, PMID:16982792] is_a: ARO:3004824 ! LAP beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "LAP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3004826 name: LAP-2 namespace: antibiotic_resistance def: "LAP-2 is an Ambler Class A beta-lactamase gene." [PMID:18550213] is_a: ARO:3004824 ! LAP beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "LAP-2" EXACT CARD_Short_Name [] [Term] id: ARO:3004827 name: LEN-35 namespace: antibiotic_resistance def: "LEN-35 is a Class A beta-lactamase gene found in Klebsiella variicola." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-35" EXACT CARD_Short_Name [] [Term] id: ARO:3004828 name: LEN-36 namespace: antibiotic_resistance def: "LEN-36 is a class A beta-lactamase gene found in Klebsiella variicola." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-36" EXACT CARD_Short_Name [] [Term] id: ARO:3004829 name: LEN-37 namespace: antibiotic_resistance def: "LEN-37 is a Class A beta-lactamase gene found in Klebsiella variicola." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-37" EXACT CARD_Short_Name [] [Term] id: ARO:3004832 name: Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics namespace: antibiotic_resistance def: "PBP2 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the penA gene, due to mutations can cause resistance to various drugs such as Penicillin and Ceftriaxone." [PMID:25845238, PMID:20511367, PMID:23587946, PMID:22155830, PMID:25403720, PMID:34013864] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000646 ! cefixime synonym: "Ngon_PBP2_BLA" EXACT CARD_Short_Name [] synonym: "penA" EXACT [] [Term] id: ARO:3004833 name: Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics namespace: antibiotic_resistance def: "Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics." [PMID:11850260] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000054 ! penicillin synonym: "Ngon_PBP1_BLA" EXACT CARD_Short_Name [] synonym: "ponA" EXACT [] [Term] id: ARO:3004835 name: Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam namespace: antibiotic_resistance def: "PilQ is an important gonococcal outer membrane component, member of secretin protein family, and involved in Type IV pilus formation." [PMID:16101998] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone synonym: "Ngon_pilQ_BLA" EXACT CARD_Short_Name [] synonym: "penC mutation" EXACT [] [Term] id: ARO:3004836 name: Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin namespace: antibiotic_resistance def: "Point mutation in the 23S rRNA of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic." [PMID:34013864, PMID:26601852, PMID:20585125, PMID:25394255, PMID:10508026, PMID:30917979] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Ngon_23S_AZM" EXACT CARD_Short_Name [] [Term] id: ARO:3004837 name: OXA-724 namespace: antibiotic_resistance def: "An OXA-12-family class D beta-lactamase identified from Aeromonas hydrophila." [PMID:11062187] is_a: ARO:3007699 ! OXA-12-like beta-lactamase synonym: "Aeromonas ampH" EXACT [] synonym: "OXA-724" EXACT CARD_Short_Name [] [Term] id: ARO:3004838 name: LEN-30 namespace: antibiotic_resistance def: "A class-A beta-lactamase from Klebsiella pneumoniae." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-30" EXACT CARD_Short_Name [] [Term] id: ARO:3004839 name: LEN-32 namespace: antibiotic_resistance def: "A class-A beta-lactamase from Klebsiella variicola." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-32" EXACT CARD_Short_Name [] [Term] id: ARO:3004840 name: LEN-34 namespace: antibiotic_resistance def: "A class-A beta-lactamase from Klebsiella variicola." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-34" EXACT CARD_Short_Name [] [Term] id: ARO:3004841 name: LEN-38 namespace: antibiotic_resistance def: "A class-A beta-lactamase from Klebsiella." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-38" EXACT CARD_Short_Name [] [Term] id: ARO:3004842 name: LEN-39 namespace: antibiotic_resistance def: "A class-A broad-spectrum beta-lactamase identified from Klebsiella sp." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-39" EXACT CARD_Short_Name [] [Term] id: ARO:3004843 name: LEN-40 namespace: antibiotic_resistance def: "A class-A broad-spectrum beta-lactamase identified from Klebsiella sp." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-40" EXACT CARD_Short_Name [] [Term] id: ARO:3004844 name: LEN-41 namespace: antibiotic_resistance def: "A class-A broad-spectrum beta-lactamase identified from Klebsiella." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-41" EXACT CARD_Short_Name [] [Term] id: ARO:3004845 name: LEN-42 namespace: antibiotic_resistance def: "A class-A broad-spectrum beta-lactamase from Klebsiella." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-42" EXACT CARD_Short_Name [] [Term] id: ARO:3004846 name: LEN-43 namespace: antibiotic_resistance def: "A class-A broad-spectrum beta-lactamase from Klebsiella." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-43" EXACT CARD_Short_Name [] [Term] id: ARO:3004847 name: LEN-51 namespace: antibiotic_resistance def: "A class-A broad-spectrum beta-lactamase from Klebsiella." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-51" EXACT CARD_Short_Name [] [Term] id: ARO:3004848 name: LEN-55 namespace: antibiotic_resistance def: "A class-A broad-spectrum beta-lactamase from Klebsiella." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-55" EXACT CARD_Short_Name [] [Term] id: ARO:3004849 name: LEN-58 namespace: antibiotic_resistance def: "A class-A broad-spectrum beta-lactamase from Klebsiella." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-58" EXACT CARD_Short_Name [] [Term] id: ARO:3004851 name: Neisseria gonorrhoeae mtrR with mutation conferring resistance namespace: antibiotic_resistance def: "MtrR is a repressor of mtrCDE efflux pump expression, point mutations in mtrR confer resistance to azithromycin and other drugs." [PMID:10508026, PMID:18761689] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Ngon_mtrR_AZM" EXACT CARD_Short_Name [] [Term] id: ARO:3004852 name: SYN-1012 namespace: antibiotic_resistance def: "An experimental serine beta-lactamase inhibitor comparable to clavulanic acid, tazobactam and sulbactam." [] is_a: ARO:3007130 ! beta-lactam derived beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000873 ! TEM-1 relationship: is_small_molecule_inhibitor ARO:3000875 ! TEM-3 relationship: is_small_molecule_inhibitor ARO:3001396 ! OXA-1 xref: pubchem.compound:23676494 [Term] id: ARO:3004853 name: Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to capreomycin namespace: antibiotic_resistance def: "Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin." [PMID:24953243] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:3003993 ! capreomycin synonym: "Mtub_16S_CAP" EXACT CARD_Short_Name [] [Term] id: ARO:3004854 name: CMY-136 namespace: antibiotic_resistance def: "A CMY-2-like beta-lactamase which confers resistance to cephalosporin antibiotics, and is also capable of hydrolyzing the CMY-2 inhibitors ticarcillin and cloxacillin." [PMID:30788955] is_a: ARO:3000069 ! CMY beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3003927 ! ceftolozane synonym: "CMY-136" EXACT CARD_Short_Name [] [Term] id: ARO:3004855 name: SCO beta-lactamase namespace: antibiotic_resistance def: "SCOs are Class A beta-lactamases that confer resistance to a narrow range of penams, with some minor activity on cephalosporins and carbapenems." [PMID:20956594, PMID:17420213, PMID:17353248] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3004856 name: SCO-1 namespace: antibiotic_resistance def: "Narrow-spectrum beta-lactamase isolated from several Acinetobacter spp. isolates from Argentina, as well as E. Coli. Hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level." [PMID:20956594, PMID:17420213, PMID:17353248] is_a: ARO:3004855 ! SCO beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000054 ! penicillin relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "A1E3K9" EXACT [] synonym: "SCO-1" EXACT CARD_Short_Name [] synonym: "blaSCO-1" EXACT [] [Term] id: ARO:3004858 name: Zoliflodacin namespace: antibiotic_resistance def: "Experimental antibiotic in phase two trial for Neisseria gonorrhoeae treatment." [PMID:31730160] is_a: ARO:3007160 ! zoliflodacin-like antibiotic xref: pubchem.compound:76685216 [Term] id: ARO:3004859 name: Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin namespace: antibiotic_resistance def: "Point mutation in Neisseria gonorrhoea gyrase B decreases affinity to zoliflodacin antibiotic." [PMID:31730160] is_a: ARO:3005000 ! Zoliflodacin resistant gyrB relationship: confers_resistance_to_antibiotic ARO:3004858 ! Zoliflodacin synonym: "Ngon_gyrB_ZOL" EXACT CARD_Short_Name [] synonym: "Ngon_gyrB_ZOL" EXACT [] [Term] id: ARO:3004860 name: Burkholderia dolosa gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in Burkholderia gyrA that confer resistance to ciprofloxacin, a fluoroquinolone antibiotic." [PMID:25153194, PMID:25931592] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Bdol_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3004861 name: NDM-18 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase and NDM-1 variant." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-18" EXACT CARD_Short_Name [] [Term] id: ARO:3004862 name: NDM-19 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase and NDM-1 variant." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-19" EXACT CARD_Short_Name [] [Term] id: ARO:3004863 name: NDM-20 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-20" EXACT CARD_Short_Name [] [Term] id: ARO:3004864 name: NDM-21 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase and NDM-1 variant." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-21" EXACT CARD_Short_Name [] [Term] id: ARO:3004865 name: NDM-22 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase and NDM-1 variant." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-22" EXACT CARD_Short_Name [] [Term] id: ARO:3004866 name: NDM-23 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-23" EXACT CARD_Short_Name [] [Term] id: ARO:3004867 name: NDM-24 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-24" EXACT CARD_Short_Name [] [Term] id: ARO:3004868 name: NDM-25 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-25" EXACT CARD_Short_Name [] [Term] id: ARO:3004869 name: NDM-26 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase and NDM-1 variant." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-26" EXACT CARD_Short_Name [] [Term] id: ARO:3004870 name: NDM-27 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase and NDM-1 variant." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-27" EXACT CARD_Short_Name [] [Term] id: ARO:3004871 name: NDM-28 namespace: antibiotic_resistance def: "A class B New Delhi metallo-beta-lactamase and NDM-1 variant." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-28" EXACT CARD_Short_Name [] [Term] id: ARO:3004873 name: Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides namespace: antibiotic_resistance def: "Point mutations in Neisseria gonorrhoeae dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance." [PMID:31358980] is_a: ARO:3003415 ! sulfonamide resistant dihydropteroate synthase folP relationship: confers_resistance_to_antibiotic ARO:3000330 ! sulfisoxazole synonym: "Ngon_folP_SLF" EXACT CARD_Short_Name [] [Term] id: ARO:3004874 name: isoniazid resistant inhA namespace: antibiotic_resistance def: "Genes with mutations in inhA which confer resistance to isoniazid class antibiotics." [] is_a: ARO:3003417 ! antibiotic resistant inhA relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004875 name: inhA with mutations with conferring resistance to ethionamide namespace: antibiotic_resistance def: "Genes with mutations in inhA which confer resistance to ethionamide class antibiotics." [] is_a: ARO:3003417 ! antibiotic resistant inhA relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3004876 name: Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide namespace: antibiotic_resistance def: "inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by ethionamide. Mutations in the promoter region or multiple copies of the inhA show marked resistance to ethionamide mediated inhibition of mycolic acid biosynthesis." [PMID:14623976, PMID:25568071, PMID:19581462] is_a: ARO:3004875 ! inhA with mutations with conferring resistance to ethionamide relationship: confers_resistance_to_antibiotic ARO:3003474 ! ethionamide synonym: "Mtub_inhA_ETO" EXACT CARD_Short_Name [] [Term] id: ARO:3004877 name: antibiotic resistant clpC1 namespace: antibiotic_resistance def: "Mutations that occur in the clp protease subunit clpC1 that increases resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004878 name: pyrazinamide resistant clpC1 namespace: antibiotic_resistance def: "clpC1 is a subunit of the clp protease that is ATP-dependent. It functions to direct the clp protease to specific substrates. In the presence of ATP it hydrolyses proteins and may be involved in the degradation of denatured proteins." [] is_a: ARO:3004877 ! antibiotic resistant clpC1 relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3004879 name: antibiotic resistant gpsI namespace: antibiotic_resistance def: "Mutations that occur in gpsI that increases resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004880 name: pyrazinamide resistant gpsI namespace: antibiotic_resistance def: "gpsI codes for polyribonucleotide nucleotidyltransferase which is a protein involved in mRNA degradation. It catalyzes the phosphorolysis of single-stranded polyribonucleotides in the 3'- to 5'-direction." [] is_a: ARO:3004879 ! antibiotic resistant gpsI relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3004881 name: antibiotic resistant mas namespace: antibiotic_resistance def: "Mutations that occur in the mas that increases resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004882 name: pyrazinamide resistant mas namespace: antibiotic_resistance def: "Mas is a multifunctional mycocerosic acid synthase membrane-associated mas. It catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA as the elongating agent to form mycocerosyl fatty acids present in mycobacterium." [] is_a: ARO:3004881 ! antibiotic resistant mas relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3004883 name: antibiotic resistant ppsC namespace: antibiotic_resistance def: "Mutations that occur in the ppsC that increases resistance to antibiotics." [] is_a: ARO:3005002 ! antibiotic resistant polyketide synthase genes [Term] id: ARO:3004884 name: pyrazinamide resistant ppsC namespace: antibiotic_resistance def: "ppsC codes for the phthiocerol synthesis polyketide synthase type 1. It is involved in the elongation of C22-24 fatty acids by the addition of methylmalonyl-CoA extender units to yield phthiocerol derivatives in a complete reduction. Research has pointed towards this protein to be a high confidence drug target." [] is_a: ARO:3004883 ! antibiotic resistant ppsC [Term] id: ARO:3004885 name: antibiotic resistant ppsD namespace: antibiotic_resistance def: "Mutations that occur in the ppsD that increases resistance to antibiotics." [] is_a: ARO:3005002 ! antibiotic resistant polyketide synthase genes [Term] id: ARO:3004886 name: pyrazinamide resistant ppsD namespace: antibiotic_resistance def: "ppsD codes for the phthiocerol synthesis polyketide synthase type 1. It is involved in the elongation of C22-24 fatty acids by the addition of malonyl-CoA extender units to yield phthiocerol derivatives in a partial reduction." [] is_a: ARO:3004885 ! antibiotic resistant ppsD [Term] id: ARO:3004887 name: antibiotic resistant fabG1 namespace: antibiotic_resistance def: "Mutations that occur in the fabg1 gene resulting in the inability for the antibiotic to inhibit mycolic acid biosynthesis." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004888 name: Ethionamide resistant fabG1 namespace: antibiotic_resistance def: "fabG1 is involved in the fatty acid synthesis pathway, acting in the first reduction step for mycolic acid. It is associated with ethionamide resistance." [] is_a: ARO:3004887 ! antibiotic resistant fabG1 relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3004889 name: antibiotic resistant mshC namespace: antibiotic_resistance def: "Mutations that occur on the mshC gene resulting in the inability for antibiotic to function." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004890 name: ethionamide resistant mshC namespace: antibiotic_resistance def: "Mutations that occur in mshC which is involved in the third step of mycothiol biosynthesis. It catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins. The gene exhibits resistance to ethionamide." [] is_a: ARO:3004889 ! antibiotic resistant mshC relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3004891 name: antibiotic resistant nudC namespace: antibiotic_resistance def: "Mutations that occur on the nudC gene resulting in the inability for antibiotic to function." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004892 name: ethionamide resistant nudC namespace: antibiotic_resistance def: "nudC is a NADH pyrophosphatase that is involved in nicotinate and nicotinamide metabolism. Mutations that occur on the nudC gene resulting in the inability for ethionamide to function." [] is_a: ARO:3004891 ! antibiotic resistant nudC relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3004893 name: antibiotic resistant ahpC namespace: antibiotic_resistance def: "Mutations in ahpC that contribute to antibiotic resistance by preventing ahpC from activating antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004894 name: Isoniazid resistant ahpC namespace: antibiotic_resistance def: "An alkyl hydroperoxide reductase that catalyzes the reduction of organic hydrogen peroxide to water and organic alcohols. Plays a role in protecting oxidative stress." [] is_a: ARO:3004893 ! antibiotic resistant ahpC relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004895 name: isoniazid resistant fabG1 namespace: antibiotic_resistance def: "fabG1 is involved in the fatty acid synthesis pathway, acting in the first reduction step for mycolic acid. It is associated with isoniazid resistance." [] is_a: ARO:3004887 ! antibiotic resistant fabG1 relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004896 name: antibiotic resistant furA namespace: antibiotic_resistance def: "Mutations that occur in furA which is in the regulatory region of katG. Mutations within the gene contribute to antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004897 name: isoniazid resistant furA namespace: antibiotic_resistance def: "Transcriptional regulator furA, represses the transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region." [] is_a: ARO:3004896 ! antibiotic resistant furA relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004898 name: antibiotic resistant inbR namespace: antibiotic_resistance def: "Mutations in inbR that contribute to antibiotic resistance by preventing antibiotic activation." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004899 name: isoniazid resistant inbR namespace: antibiotic_resistance def: "inbR is part of the transcriptional factor family TetR. It acts as a repressor to regulate efflux pumps involved in antibiotic resistance." [] is_a: ARO:3004898 ! antibiotic resistant inbR relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic synonym: "Rv0275c" EXACT [] [Term] id: ARO:3004900 name: antibiotic resistant mshA namespace: antibiotic_resistance def: "Mutations that occur in the mshA gene resulting in the inability for antibiotic to activate." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004901 name: isoniazid resistant mshA namespace: antibiotic_resistance def: "mshA is a glycosyltransferase and is involved in the first step of mycothiol biosynthesis. This is a step that is required for growth in mycobacterium tuberculosis. Resistance has been shown in the gene to isoniazid." [] is_a: ARO:3004900 ! antibiotic resistant mshA relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004902 name: antibiotic resistant mshB namespace: antibiotic_resistance def: "Mutations that occur in the mshB gene that results in antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004903 name: isoniazid resistant mshB namespace: antibiotic_resistance def: "mshB is a deacetylase that is involved in the second step of mycothiol synthesis. GlcNAc-Ins is deacetylated by MshB to produce GlcN-Ins." [] is_a: ARO:3004902 ! antibiotic resistant mshB relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004904 name: isoniazid resistant mshC namespace: antibiotic_resistance def: "Mutations that occur on the mshC gene resulting in the inability for isoniazid to function. It catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins." [] is_a: ARO:3004889 ! antibiotic resistant mshC relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004905 name: antibiotic resistant mymA namespace: antibiotic_resistance def: "Mutations that occur within the coding region of mymA that prevent effective antibiotic function." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004906 name: isoniazid resistant mymA namespace: antibiotic_resistance def: "mymA is an operon that begins at Rv3083 and ends at Rv3089 and is required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. It has shown to be resistant to isoniazid." [] is_a: ARO:3004905 ! antibiotic resistant mymA relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004907 name: antibiotic resistant mmaA3 namespace: antibiotic_resistance def: "Mutations that occur in mmaA3 which decreases effective functioning of antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004908 name: isoniazid resistant mmaA3 namespace: antibiotic_resistance def: "Methoxy mycolic acid synthase 3 is involved in the modification of mycolic acids. It represents a major part of the mycobacterial cell wall complex." [] is_a: ARO:3004907 ! antibiotic resistant mmaA3 relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004909 name: Antibiotic resistant nat namespace: antibiotic_resistance def: "Mutations that occur in nat inactivate antibiotic functioning and contribute to antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004910 name: isoniazid resistant nat namespace: antibiotic_resistance def: "Arylamine N-acetyltransferase catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines. Reports have shown that overexpression of this enzyme may be responsible for increased resistance to isoniazid." [] is_a: ARO:3004909 ! Antibiotic resistant nat relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004911 name: isoniazid resistant nudC namespace: antibiotic_resistance def: "nudC is a NADH pyrophosphatase that is involved in nicotinate and nicotinamide metabolism. Mutations that occur on the nudC gene resulting in the inability for isoniazid to function." [] is_a: ARO:3004891 ! antibiotic resistant nudC relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004912 name: antibiotic resistant sigI namespace: antibiotic_resistance def: "Mutations that occur in SigI sigma factor that increase resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004913 name: isoniazid resistant sigI namespace: antibiotic_resistance def: "A sigma factor that acts as an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. Transcriptional analyses indicate that katG is also regulated by the sigma factor sigl and indicate resistance to isoniaizd." [] is_a: ARO:3004912 ! antibiotic resistant sigI relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3004915 name: fluoroquinolone-resistant ESX5 secretion system namespace: antibiotic_resistance def: "ESX-5 secretion system is are important for virulence of mycobacteria and is required for mycobacterial cell wall stability and host cell lysis. The system is comprised of genes that encode the structural components of the secretion system. The system secrets mycobacterial proteins involved in virulence and pathogenicity and important for mycobacterium viability. Resistance has been shown to specific antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004916 name: subunits of secretion system conferring antibiotic resistance namespace: antibiotic_resistance def: "Subunits of the secretion system complex that secretes proteins that contribute to resistance." [] is_a: ARO:3000000 ! determinant of antibiotic resistance [Term] id: ARO:3004917 name: fluoroquinolone resistant eccB5 namespace: antibiotic_resistance def: "Mutations in the eccB5 gene contributing to antibiotic resistance to fluoroquinolone." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004916 ! subunits of secretion system conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: part_of ARO:3004915 ! fluoroquinolone-resistant ESX5 secretion system [Term] id: ARO:3004918 name: Mycobacterium tuberculosis eccB5 conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "eccB5 is a transmembrane protein within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane." [PMID:34161790] is_a: ARO:3004917 ! fluoroquinolone resistant eccB5 relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin synonym: "Mtub_eccB5_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3004919 name: Mycobacterium tuberculosis eccC5 conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "eccC5 is a membrane-bound ATPase within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane, yet the Relational Sequencing Tuberculosis Data platform (ReSeqTB, https://platform.reseqtb.org) finds no evidence of an association between eccC5 mutations and drug resistance." [PMID:30337678] is_a: ARO:3004920 ! fluoroquinolone resistant eccC5 relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin synonym: "Mtub_eccC5_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3004920 name: fluoroquinolone resistant eccC5 namespace: antibiotic_resistance def: "Mutations in the eccC5 gene contributing to antibiotic resistance to fluoroquinolone." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3004916 ! subunits of secretion system conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: part_of ARO:3004915 ! fluoroquinolone-resistant ESX5 secretion system [Term] id: ARO:3004921 name: Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in ahpC that result in ahpC overexpression thus conferring or contributing to resistance to isoniazid." [PMID:8830260] is_a: ARO:3004894 ! Isoniazid resistant ahpC relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_ahpC_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004922 name: Mycobacterium tuberculosis fabG1 mutations confer resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in fabG1 resulting in or contributing to resistance in isoniazid." [PMID:16189082] is_a: ARO:3004895 ! isoniazid resistant fabG1 relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_fabG1_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004923 name: Mycobacterium tuberculosis furA mutations confer resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in furA that result in or contribute to antibiotic resistance to isoniazid." [PMID:25092698, PMID:24055765] is_a: ARO:3004897 ! isoniazid resistant furA relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_furA_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004924 name: Mycobacterium tuberculosis inbR mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in inbR that result in or contribute to antibiotic resistance to isoniazid." [PMID:26353937] is_a: ARO:3004899 ! isoniazid resistant inbR relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_inbR_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004925 name: Mycobacterium tuberculosis mshA mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in Mycobacterium tuberculosis mshA that result in or contribute to antibiotic resistance to isoniazid." [PMID:30583053] is_a: ARO:3004901 ! isoniazid resistant mshA relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_mshA_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004927 name: Mycobacterium tuberculosis mshC mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in mshC that result in or contribute to antibiotic resistance to isoniazid." [PMID:26104204] is_a: ARO:3004904 ! isoniazid resistant mshC relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_mshC_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004928 name: Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in the mymA operon that result in or contribute to antibiotic resistance to isoniazid." [PMID:30082293] is_a: ARO:3004906 ! isoniazid resistant mymA relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_mymA_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004929 name: Mycobacterium tuberculosis mmaA3 mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in mmaA3 that result in or contribute to antibiotic resistance to isoniazid." [PMID:33055230, PMID:21426023] is_a: ARO:3004908 ! isoniazid resistant mmaA3 relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_mmaA3_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004930 name: Mycobacterium tuberculosis nat mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in nat which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid." [PMID:26104204] is_a: ARO:3004910 ! isoniazid resistant nat relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_nat_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004931 name: Mycobacterium tuberculosis nudC mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations that occur in nudC which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid." [PMID:26104204] is_a: ARO:3004911 ! isoniazid resistant nudC relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_nudC_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004932 name: Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid." [PMID:26104204] is_a: ARO:3004913 ! isoniazid resistant sigI relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_sigI_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3004933 name: Mycobacterium tuberculosis fabG1 mutation conferring resistance to ethionamide namespace: antibiotic_resistance def: "Mutations that occur in Mycobacterium tuberculosis fabG1 resulting in or contributing to resistance in ethionamide." [PMID:16189082] is_a: ARO:3004888 ! Ethionamide resistant fabG1 relationship: confers_resistance_to_antibiotic ARO:3003474 ! ethionamide synonym: "Mtub_fabG1_ETO" EXACT CARD_Short_Name [] [Term] id: ARO:3004934 name: Mycobacterium tuberculosis mshC mutations conferring resistance to ethionamide namespace: antibiotic_resistance def: "Mutations that occur in mshC resulting in or contributing to conferring resistance to ethionamide." [PMID:26104204] is_a: ARO:3004890 ! ethionamide resistant mshC relationship: confers_resistance_to_antibiotic ARO:3003474 ! ethionamide synonym: "Mtub_mshC_ETO" EXACT CARD_Short_Name [] [Term] id: ARO:3004935 name: Mycobacterium tuberculosis nudC mutations conferring resistance to ethionamide namespace: antibiotic_resistance def: "Mutations that occur in nudC resulting in or contributing to conferring resistance to ethionamide." [PMID:26104204] is_a: ARO:3004892 ! ethionamide resistant nudC relationship: confers_resistance_to_antibiotic ARO:3003474 ! ethionamide synonym: "Mtub_nudC_ETO" EXACT CARD_Short_Name [] [Term] id: ARO:3004936 name: 23s rRNA with mutation conferring resistance to aminoglycoside antibiotics namespace: antibiotic_resistance def: "Point mutations in the 23S rRNA of bacteria can confer resistance to aminoglycosides." [] is_a: ARO:3000336 ! 23S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004937 name: Mycobacterium tuberculosis 23S rRNA mutation conferring resistance to capreomycin namespace: antibiotic_resistance def: "Point mutations in 23S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin." [PMID:16857584] is_a: ARO:3004936 ! 23s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:3003993 ! capreomycin synonym: "Mtub_23S_CAP" EXACT CARD_Short_Name [] [Term] id: ARO:3004938 name: antibiotic resistant ddlA namespace: antibiotic_resistance def: "Mutations in the D-alanine synthase of Mycobacterium tuberculosis can confer resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3000723 ! cycloserine sensitive D-alanine synthetase [Term] id: ARO:3004939 name: cycloserine resistant ddlA namespace: antibiotic_resistance def: "ddlA catalyzes the ATP-driven ligation of two D-alanine molecules to form the D-alanyl-D-alanine dipeptide, key in forming the cell wall. Cycloserine has a similar structure to d-alanine and inhibits the growth of the cell wall." [] is_a: ARO:3004938 ! antibiotic resistant ddlA relationship: confers_resistance_to_drug_class ARO:3007154 ! cycloserine-like antibiotic [Term] id: ARO:3004941 name: Mycobacterium tuberculosis ddlA mutations confer resistance to cycloserine namespace: antibiotic_resistance def: "Point mutations that occur within Mycobacterium tuberculosis ddlA gene resulting in resistance to cycloserine." [PMID:28231674] is_a: ARO:3004939 ! cycloserine resistant ddlA relationship: confers_resistance_to_antibiotic ARO:3000760 ! cycloserine synonym: "Mtub_ddlA_DCS" EXACT CARD_Short_Name [] [Term] id: ARO:3004942 name: antibiotic resistant ald namespace: antibiotic_resistance def: "Mutations that occur in ald which decreases effective functioning of antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004943 name: cycloserine resistant ald namespace: antibiotic_resistance def: "ald plays a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer. Resistance due to mutations in ald can cause cycloserine to not function." [] is_a: ARO:3004942 ! antibiotic resistant ald relationship: confers_resistance_to_drug_class ARO:3007154 ! cycloserine-like antibiotic [Term] id: ARO:3004944 name: antibiotic resistant alr namespace: antibiotic_resistance def: "Mutations that occur in alr which decreases effective functioning of antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004945 name: Mycobacterium tuberculosis ald mutations confer resistance to cycloserine namespace: antibiotic_resistance def: "Mutations in the ald gene that contribute to or confer resistance to cycloserine." [PMID:27064254] is_a: ARO:3004943 ! cycloserine resistant ald relationship: confers_resistance_to_antibiotic ARO:3000760 ! cycloserine synonym: "Mtub_ald_DCS" EXACT CARD_Short_Name [] [Term] id: ARO:3004946 name: cycloserine resistant alr namespace: antibiotic_resistance def: "Provides the D-alanine required for cell wall biosynthesis. Transforms L-alanine to D-alanine. Can confer resistance to cycloserine." [] is_a: ARO:3004944 ! antibiotic resistant alr relationship: confers_resistance_to_drug_class ARO:3007154 ! cycloserine-like antibiotic [Term] id: ARO:3004947 name: Mycobacterium tuberculosis alr with mutation conferring resistance to cycloserine namespace: antibiotic_resistance def: "Mutations in the alr mutation contribute to or confer resistance to cycloserine." [PMID:28971867] is_a: ARO:3004946 ! cycloserine resistant alr relationship: confers_resistance_to_antibiotic ARO:3000760 ! cycloserine synonym: "Mtub_alr_DCS" EXACT CARD_Short_Name [] [Term] id: ARO:3004948 name: antibiotic resistant ubiA namespace: antibiotic_resistance def: "Decaprenylphosphoryl-5-phosphoribose (DPPR) synthase involved in arabinogalactan synthesis." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004949 name: ethambutol resistant ubiA namespace: antibiotic_resistance def: "DDPR synthase involved in arabinogalactan synthesis. Mutations can confer resistance to ethambutol." [] is_a: ARO:3004948 ! antibiotic resistant ubiA relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic [Term] id: ARO:3004950 name: Mycobacterium tuberculosis ubiA mutations confer resistance to ethambutol namespace: antibiotic_resistance def: "Mutations in the ubiA gene contribute to or confer resistance to ethambutol." [PMID:30711156] is_a: ARO:3004949 ! ethambutol resistant ubiA relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_ubiA_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3004951 name: Mycobacterium tuberculosis aftA mutations confer resistance to ethambutol namespace: antibiotic_resistance def: "Mutations in aftA gene contribute to or confer resistance to ethamutol." [PMID:29084750, PMID:23995136] is_a: ARO:3002876 ! ethambutol resistant aftA relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol synonym: "Mtub_aftA_EMB" EXACT CARD_Short_Name [] [Term] id: ARO:3004952 name: thioacetazone namespace: antibiotic_resistance def: "Thioacetazone is an inexpensive, antitubercular, bacteriostatic drug that has been widely used in combination with isoniazid in Africa and South America. This drug is rarely in use." [PMID:18094751] is_a: ARO:3007161 ! thiosemicarbazone antibiotic synonym: "amithiozone" EXACT [] synonym: "thiacetazone" EXACT [] xref: pubchem.compound:9568512 [Term] id: ARO:3004953 name: antibiotic resistant Rv0565c namespace: antibiotic_resistance def: "Rv0565c is a bacterial monoxygenase that has been newly uncovered in recent literature to show resistance to antibiotic." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004954 name: Ethionamide resistant Rv0565c namespace: antibiotic_resistance def: "Mycobacterial monoxygenase has been shown to confer resistance to ethionamide in recent literature." [] is_a: ARO:3004953 ! antibiotic resistant Rv0565c relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3004955 name: Mycobacterium tuberculosis Rv0565c mutation conferring resistance to ethionamide namespace: antibiotic_resistance def: "Mutations in a bacterial monooxygenase, Rv0565c, are significantly associated with ethionamide resistance as an activator of ethionamide." [PMID:31015328] is_a: ARO:3004954 ! Ethionamide resistant Rv0565c relationship: confers_resistance_to_antibiotic ARO:3003474 ! ethionamide synonym: "Mtub_Rv0565_ETO" EXACT CARD_Short_Name [] [Term] id: ARO:3004956 name: Neisseria gonorrhoeae rpld namespace: antibiotic_resistance def: "rpld encodes for the 50S L4 ribosomal protein, is a macrolide resistance protein identified in Neisseria gonorrhoeae." [PMID:27638945, PMID:26935729] is_a: ARO:3005001 ! 50S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "Ngon_rpld" EXACT CARD_Short_Name [] [Term] id: ARO:3004957 name: Mycobacterium tuberculosis clpC1 with mutation conferring resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations that occur in clpC1 that result in or contribute to antibiotic resistance to pyrazinamide." [PMID:28271875, PMID:33722890] is_a: ARO:3004878 ! pyrazinamide resistant clpC1 relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_clpC1_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004958 name: antibiotic resistant ponA1 namespace: antibiotic_resistance def: "A probable bifunctional penicillin-binding protein that is involved in the final stages of peptidoglycan synthesis. It has been shown to cause resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004959 name: rifamycin resistant ponA1 namespace: antibiotic_resistance def: "Mutations in the ponA1 gene that can contribute to or confer resistance to rifamycin-class antibiotics." [] is_a: ARO:3004958 ! antibiotic resistant ponA1 relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic [Term] id: ARO:3004960 name: Mycobacterium tuberculosis ponA1 mutations confer resistance to rifabutin namespace: antibiotic_resistance def: "Mutations in ponA1 that contribute to or confer resistance to rifabutin antibiotic." [PMID:24962424, PMID:23995135] is_a: ARO:3004959 ! rifamycin resistant ponA1 relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin synonym: "Mtub_ponA1_RFB" EXACT CARD_Short_Name [] [Term] id: ARO:3004961 name: antibiotic resistant eis namespace: antibiotic_resistance def: "Mutations in the eis gene that can contribute to antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004962 name: kanamycin resistant eis namespace: antibiotic_resistance def: "Involved in acetylation and intracellular survival. Associated with the cell surface and secretion proteins." [] is_a: ARO:3004961 ! antibiotic resistant eis relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004963 name: Mycobacterium tuberculosis eis mutations confer resistance to kanamycin namespace: antibiotic_resistance def: "Mutations in eis that contribute to or confer resistance to kanamycin." [PMID:19906990] is_a: ARO:3004962 ! kanamycin resistant eis relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Mtub_eis_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3004964 name: antibiotic resistant whib7 namespace: antibiotic_resistance def: "Mutations in the whib7 gene that cause antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004965 name: streptomycin resistant whib7 namespace: antibiotic_resistance def: "A protein involved in transcriptional mechanisms. Mutations in the gene can cause resistance to streptomycin." [] is_a: ARO:3004964 ! antibiotic resistant whib7 relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004966 name: Kanamycin resistant whib7 namespace: antibiotic_resistance def: "whib7 is a protein involved in transcriptional mechanisms. Mutations in the gene can cause resistance to kanamycin." [] is_a: ARO:3004964 ! antibiotic resistant whib7 relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004967 name: Mycobacterium tuberculosis whib7 mutations confer resistance to kanamycin namespace: antibiotic_resistance def: "Mutations in whib7 that can contribute to or confer resistance to kanamycin." [PMID:23380727] is_a: ARO:3004966 ! Kanamycin resistant whib7 relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Mtub_whib7_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3004968 name: Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin namespace: antibiotic_resistance def: "Mutations in whib7 that can contribute to or confer resistance to streptomycin." [PMID:23380727] is_a: ARO:3004965 ! streptomycin resistant whib7 relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Mtub_whib7_STR" EXACT CARD_Short_Name [] synonym: "whmC" EXACT [] [Term] id: ARO:3004970 name: streptomycin resistant Rv1258c namespace: antibiotic_resistance def: "An efflux pump in mycobacterium that contributes to intrinsic antibiotic resistance. The pump uses the electrochemical gradient as a source of energy." [] is_a: ARO:3007183 ! antibiotic resistant Rv1258c relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3004971 name: Mycobacterium tuberculosis Rv1258c mutations confer resistance to streptomycin namespace: antibiotic_resistance def: "Mutations in the Rv1258c (Tap) gene that can contribute to or confer resistance to streptomycin." [PMID:30837962] is_a: ARO:3004970 ! streptomycin resistant Rv1258c relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "Mtub_tap_STR" EXACT CARD_Short_Name [] [Term] id: ARO:3004972 name: antibiotic resistant ppsA namespace: antibiotic_resistance def: "Mutations in ppsA can result in antibiotic resistance." [] is_a: ARO:3005002 ! antibiotic resistant polyketide synthase genes [Term] id: ARO:3004973 name: pyrazinamide resistant ppsA namespace: antibiotic_resistance def: "Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. Mutations in the gene may confer resistance to pyrazinamide." [] is_a: ARO:3004972 ! antibiotic resistant ppsA [Term] id: ARO:3004975 name: Mycobacterium tuberculosis ppsC mutations confer resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations in ppsC can contribute to or confer resistance to pyrazinamide." [PMID:29686155] is_a: ARO:3004884 ! pyrazinamide resistant ppsC relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_ppsC_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004976 name: Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations in ppsD can contribute to or confer resistance to pyrazinamide." [PMID:30333483] is_a: ARO:3004886 ! pyrazinamide resistant ppsD relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_ppsD_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004977 name: Mycobacterium tuberculosis gpsI with mutations conferring resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations in gpsI that can contribute to or confer resistance to pyrazinamide." [PMID:29020922] is_a: ARO:3004880 ! pyrazinamide resistant gpsI relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_gpsI_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004978 name: Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations in mas that can contribute to or confer resistance to pyrazinamide." [PMID:27759369] is_a: ARO:3004882 ! pyrazinamide resistant mas relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_mas_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004979 name: antibiotic resistant Rv0191 namespace: antibiotic_resistance def: "Mutations in the gene can contribute to antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant synonym: "Chloramphenicol efflux pump" EXACT [] synonym: "Rv0191" EXACT [] [Term] id: ARO:3004980 name: pyrazinamide resistant Rv0191 namespace: antibiotic_resistance def: "A probable conserved integral membrane protein that acts as an active efflux pump. Overexpression causes pyrazinamide resistance." [] is_a: ARO:3004979 ! antibiotic resistant Rv0191 relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3004981 name: Mycobacterium tuberculosis Rv0191 mutations confer resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations in the Rv0191 gene contribute to or confer resistance to pyrazinamide." [PMID:28584158] is_a: ARO:3004980 ! pyrazinamide resistant Rv0191 relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_Rv0191_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004982 name: antibiotic resistant Rv1667 namespace: antibiotic_resistance def: "Mutations in the Rv1667 gene can contribute or confer resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004983 name: pyrazinamide resistant Rv1667 namespace: antibiotic_resistance def: "A probable transport protein thought to be involved in the active transport of macrolide across the membrane in mycobacterium." [] is_a: ARO:3004982 ! antibiotic resistant Rv1667 relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3004984 name: Mycobacterium tuberculosis Rv1667 mutations confer resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations in the Rv1667 gene that can contribute to or confer resistance to pyrazinamide. Resistance may be due to an antibiotic export mechanism." [PMID:28584158] is_a: ARO:3004983 ! pyrazinamide resistant Rv1667 relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_Rv1667_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004985 name: antibiotic resistant Rv2731 namespace: antibiotic_resistance def: "Mutations in the Rv2731 gene that contribute to antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004986 name: pyrazinamide resistant Rv2731 namespace: antibiotic_resistance def: "A conserved alanine and arginine-rich protein with an unknown function. The protein has shown to contribute to or confer resistance to pyrazinamide." [] is_a: ARO:3004985 ! antibiotic resistant Rv2731 relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3004987 name: Mycobacterium tuberculosis Rv2731 mutations confer resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations in the Rv2731 gene that contribute to or confer resistance to pyrazinamide." [PMID:29020922] is_a: ARO:3004986 ! pyrazinamide resistant Rv2731 relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_Rv2731_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004988 name: antibiotic resistant Rv3008 namespace: antibiotic_resistance def: "Mutations in Rv3008 can contribute to or confer resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004989 name: pyrazinamide resistant Rv3008 namespace: antibiotic_resistance def: "A hypothetical protein for which it has been predicted but no experimental evidence exists to determine its function. May contribute to pyrazinamide resistance." [] is_a: ARO:3004988 ! antibiotic resistant Rv3008 relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3004991 name: antibiotic resistant Rv3169 namespace: antibiotic_resistance def: "Mutations in the Rv3169 gene contribute to or confer resistance to antibiotics." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3004992 name: pyrazinamide resistant Rv3169 namespace: antibiotic_resistance def: "A conserved protein with an unknown function determined through proteomics study. May contribute or confer resistance to pyrazinamide resistance." [] is_a: ARO:3004991 ! antibiotic resistant Rv3169 relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3004993 name: Mycobacterium tuberculosis Rv3169 mutations confer resistance to pyrazinamide namespace: antibiotic_resistance def: "Mutations in the Rv3169 gene that can contribute to or confer resistance to pyrazinamide resistance." [PMID:29020922] is_a: ARO:3004992 ! pyrazinamide resistant Rv3169 relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_Rv3169_PZA" EXACT CARD_Short_Name [] [Term] id: ARO:3004994 name: Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin namespace: antibiotic_resistance def: "Mutations in rpoC that contribute to or confer resistance to rifampicin antibiotic." [PMID:23208709] is_a: ARO:3004995 ! rifampicin resistant rpoC relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin synonym: "Mtub_rpoC_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3004995 name: rifampicin resistant rpoC namespace: antibiotic_resistance def: "rpoC catalyzes the transcription of DNA into RNA and mutations confer resistance to rifampicin." [] is_a: ARO:3003289 ! antibiotic resistant rpoC relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic [Term] id: ARO:3004996 name: antibiotic sensitive beta-prime subunit of RNA polymerase (rpoA) namespace: antibiotic_resistance def: "RNA polymerase is a multisubunit enzyme that is necessary for transcription. Catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates." [] is_a: ARO:3000712 ! nucleic acid synthesis machinery targeted by antibiotic [Term] id: ARO:3004997 name: antibiotic resistant rpoA namespace: antibiotic_resistance def: "RNA polymerase is a multisubunit enzyme that is necessary for transcription. Mutations in rpoA gene confer antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: derives_from ARO:3004996 ! antibiotic sensitive beta-prime subunit of RNA polymerase (rpoA) [Term] id: ARO:3004998 name: rifampicin resistant rpoA namespace: antibiotic_resistance def: "rpoA catalyzes the transcription of DNA into RNA and mutations confer resistance to rifampicin." [] is_a: ARO:3004997 ! antibiotic resistant rpoA relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic [Term] id: ARO:3004999 name: Mycobacterium tuberculosis rpoA mutations confer resistance to rifampicin namespace: antibiotic_resistance def: "Mutations in rpoA that contribute to or confer resistance to rifampicin antibiotic." [PMID:23208709] is_a: ARO:3004998 ! rifampicin resistant rpoA relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "Mtub_rpoA_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3005000 name: Zoliflodacin resistant gyrB namespace: antibiotic_resistance def: "Point mutations in DNA gyrase subunit B (gyrB) of Neisseria gonorrhoeae can result in resistance to Zoliflodacin." [] is_a: ARO:3000220 ! antibiotic resistant DNA topoisomerase subunit gyrB relationship: confers_resistance_to_drug_class ARO:3007160 ! zoliflodacin-like antibiotic [Term] id: ARO:3005001 name: 50S rRNA with mutation conferring resistance to macrolide antibiotics namespace: antibiotic_resistance def: "Nucleotide point mutations in the 50S rRNA subunit (not in the 23s rRNA range) may confer resistance to macrolide antibiotics." [] is_a: ARO:3005003 ! 50S rRNA with mutation conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic [Term] id: ARO:3005002 name: antibiotic resistant polyketide synthase genes namespace: antibiotic_resistance def: "Genes ppsA-E constitute an operon encoding enzymes involved in the biosynthesis of phthiocerol dimycocerosate and other lipids in Mycobacterium tuberculosis. Mutations within this region can result in resistance to pyrazinamide." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3005003 name: 50S rRNA with mutation conferring antibiotic resistance namespace: antibiotic_resistance def: "Mutations in the prokaryotic 50S ribosomal RNA subunit which disrupt binding sites and thereby reduce antibiotic efficacy." [] is_a: ARO:3000328 ! rRNA with mutation conferring antibiotic resistance [Term] id: ARO:3005004 name: Neisseria gonorrhoeae mtrC with mutation conferring resistance to azithromycin namespace: antibiotic_resistance def: "Mutation in the mtrC efflux pump of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic." [PMID:21933917] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3000369 ! MtrCDE synonym: "Ngon_mtrC_AZM" EXACT CARD_Short_Name [] [Term] id: ARO:3005005 name: antibiotic-resistant emb arabinosyltransferase namespace: antibiotic_resistance def: "Known antibiotic-resistant variants of emb arabinosyltransferases, primarily in Mycobacterium and conferring resistance to ethambutol through point mutation." [PMID:18174142] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3005006 name: tet(57) namespace: antibiotic_resistance def: "A tetracycline efflux MFS Transporter from Providencia sp. Y14." [PMID:11381101] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(57)" EXACT CARD_Short_Name [] [Term] id: ARO:3005007 name: QnrVC2 namespace: antibiotic_resistance def: "QnrVC2 is a class 1 integron found in Ciprofloxacin-resistant Vibro choleraeO1." [PMID:18598639] is_a: ARO:3000419 ! quinolone resistance protein (qnr) relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "QnrVC2" EXACT CARD_Short_Name [] [Term] id: ARO:3005008 name: TxR namespace: antibiotic_resistance def: "TxR is a putative transcription regulator that plays a role in conferring tetracycline resistance. It is required for proper functioning of Tet35." [PMID:11897587] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000481 ! tet(35) synonym: "TxR" EXACT CARD_Short_Name [] [Term] id: ARO:3005009 name: qacE namespace: antibiotic_resistance def: "QacE is a resistance gene conferring resistance to antiseptics." [PMID:10339831] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics synonym: "qacE" EXACT CARD_Short_Name [] [Term] id: ARO:3005010 name: qacEdelta1 namespace: antibiotic_resistance def: "QacEdelta1 is a resistance gene conferring resistance to antiseptics. It is different from QacE only at the 3'-terminus." [PMID:10339831] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics synonym: "qacEdelta1" EXACT CARD_Short_Name [] [Term] id: ARO:3005011 name: IDC beta-lactamase namespace: antibiotic_resistance def: "IDC beta-lactamases are class C beta-lactamases inc. cephalosporinases and carbapenemases." [PMID:32183280] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005012 name: IDC-1 namespace: antibiotic_resistance def: "IDC-2 is an IDC beta-lactamase and an integron cephalosprinase." [PMID:32183280] is_a: ARO:3005011 ! IDC beta-lactamase synonym: "IDC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3005013 name: IDC-2 namespace: antibiotic_resistance def: "IDC-2 is an IDC beta-lactamase and an integron cephalosprinase." [PMID:32183280] is_a: ARO:3005011 ! IDC beta-lactamase synonym: "IDC-2" EXACT CARD_Short_Name [] [Term] id: ARO:3005014 name: VMB beta-lactamase namespace: antibiotic_resistance def: "Vibro metallo-B-lactamase, also known as VMB is a carbapenemase beta-lactamase gene family." [PMID:32293144] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005015 name: VMB-1 namespace: antibiotic_resistance def: "Vibrio metallo-B-lactamase 1, also known as VMB-1, is carbapenemase beta-lactamase that is found in plasmid pVB1796 from Vibrio alginolyticus." [PMID:32293144] is_a: ARO:3005014 ! VMB beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime synonym: "VMB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3005016 name: CMY-150 namespace: antibiotic_resistance def: "CMY-150 is a CMY-2 variant differing by 15 amino-acid substitutions. It confers higher resistance levels to ceftazidime and aztreonam compared to CMY-2." [PMID:31785341] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-150" EXACT CARD_Short_Name [] [Term] id: ARO:3005017 name: LMB beta-lactamase namespace: antibiotic_resistance def: "LMB is an AMR Gene family belonging to subclass B3 metallo-beta-lactamases." [PMID:31785341] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3005018 name: LMB-1 namespace: antibiotic_resistance def: "LMB-1 is a subclass B3 metallo-beta-lactamase that confers resistance to penams, cephalosporins, and carbapenems." [PMID:31785341] is_a: ARO:3005017 ! LMB beta-lactamase synonym: "LMB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3005019 name: IMP-68 namespace: antibiotic_resistance def: "IMP-68 is a subclass B1 metallo-beta-lactamase that confers resistance to carbapenems." [PMID:31666316] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-68" EXACT CARD_Short_Name [] [Term] id: ARO:3005020 name: cfr(D) Group namespace: antibiotic_resistance def: "The cfr(D) group are cfr(D) genes found in Enterococcus faecium that confer resistance to vancomycin, teicoplanin and linezolid." [PMID:32277823, PMID:31685464] is_a: ARO:3000202 ! Cfr 23S ribosomal RNA methyltransferase [Term] id: ARO:3005021 name: cfr(D) namespace: antibiotic_resistance def: "cfr(D) is found in Enterococcus faecium. It confers resistance to vancomycin, teicoplanin, and linezolid." [PMID:31685464, PMID:32277823] is_a: ARO:3005020 ! cfr(D) Group relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_antibiotic ARO:0000029 ! teicoplanin relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid synonym: "cfr(D)" EXACT CARD_Short_Name [] [Term] id: ARO:3005022 name: cfr(E) Group namespace: antibiotic_resistance def: "cfr(E) is a cfr-like gene described by (Stojkovic et al, 2019). It is found on transposon Tn6218 and found in Clostridioides difficile." [PMID:31685464] is_a: ARO:3000202 ! Cfr 23S ribosomal RNA methyltransferase [Term] id: ARO:3005023 name: cfrE namespace: antibiotic_resistance def: "The gene cfr(E) is a cfr-like gene found in Clostridioides difficile isolate DF11. It confers resistance to antibiotics targeting to the 23s rRNA through hypermethylation of nucleotide A2503." [PMID:31685464] is_a: ARO:3005022 ! cfr(E) Group relationship: confers_resistance_to_antibiotic ARO:3000456 ! thiamphenicol relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin synonym: "cfr(E)" EXACT [] synonym: "cfrE" EXACT CARD_Short_Name [] [Term] id: ARO:3005024 name: FosL1 namespace: antibiotic_resistance def: "FosL1 is related to FosA-like genes. It is a plasmid-encoded fosfomycin resistant gene found in E. coli." [PMID:31932373] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosL1" EXACT CARD_Short_Name [] [Term] id: ARO:3005025 name: ATP synthase inhibitor namespace: antibiotic_resistance def: "Antibiotic adjuvants shown to inhibit the action of ATP synthase, restoring antibiotic activity by depolarizing the bacterial membrane." [] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry [Term] id: ARO:3005026 name: venturicidin A namespace: antibiotic_resistance def: "Venturicidin A is an ATP synthase inhibitor and antibiotic adjuvant produced in actinomycetes. In the presence of aminoglycoside antibiotics such as gentamicin, Venturicidin A showed to restore susceptibility to aminoglycosides in resistant bacteria." [PMID:32424122] is_a: ARO:3005025 ! ATP synthase inhibitor synonym: "VentA" EXACT [] xref: pubchem.compound:6438066 [Term] id: ARO:3005027 name: FRI-4 namespace: antibiotic_resistance def: "FRI-4 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae." [PMID:30060114] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-4" EXACT CARD_Short_Name [] [Term] id: ARO:3005028 name: FRI-5 namespace: antibiotic_resistance def: "FRI-5 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae." [] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-5" EXACT CARD_Short_Name [] [Term] id: ARO:3005029 name: FRI-6 namespace: antibiotic_resistance def: "FRI-6 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae." [PMID:31725164] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-6" EXACT CARD_Short_Name [] [Term] id: ARO:3005030 name: FRI-7 namespace: antibiotic_resistance def: "FRI-7 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae." [] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-7" EXACT CARD_Short_Name [] [Term] id: ARO:3005031 name: FRI-8 namespace: antibiotic_resistance def: "FRI-8 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter sp. 18A13. It is from a plasmid." [] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-8" EXACT CARD_Short_Name [] [Term] id: ARO:3005032 name: FRI-9 namespace: antibiotic_resistance def: "FRI-9 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae." [] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-9" EXACT CARD_Short_Name [] [Term] id: ARO:3005033 name: FLC-1 namespace: antibiotic_resistance def: "FLC-1 is part of the FRI beta-lactamase family. It is a class A carbapenem-hydrolyzing beta-lactamase from Enterobacter cloacae." [] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FLC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3005034 name: YRC Beta-lactamase namespace: antibiotic_resistance def: "YRC is a ambler class C beta-lactamase from Yersinia ruckeri. It confers resistance penams and cephalosporins." [PMID:16553832] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3005035 name: Yrc-1 namespace: antibiotic_resistance def: "Yrc-1 is a ampC-like beta-lactamase that confers resistance to penams and cephalosporins. It is an ambler class C beta-lactamase." [PMID:16553832] is_a: ARO:3005034 ! YRC Beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "Yrc-1" EXACT CARD_Short_Name [] [Term] id: ARO:3005036 name: BLMT namespace: antibiotic_resistance def: "BLMT is a bleomycin (Bm) resistance protein, encoded by the ble gene on the transposon Tn5. This protein confers a survival advantage to Escherichia coli host cells. BLMT confers resistance to bleomycin." [PMID:9923599] is_a: ARO:3004256 ! Bleomycin resistant protein relationship: confers_resistance_to_antibiotic ARO:0000053 ! bleomycin synonym: "BLMT" EXACT CARD_Short_Name [] [Term] id: ARO:3005037 name: ADC-159 namespace: antibiotic_resistance def: "ADC-159 is an ADC beta-lactamase and a ambler class C beta-lactamase." [] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC-159" EXACT CARD_Short_Name [] [Term] id: ARO:3005038 name: PDC-65 namespace: antibiotic_resistance def: "PDC-65 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-65" EXACT CARD_Short_Name [] [Term] id: ARO:3005039 name: PDC-55 namespace: antibiotic_resistance def: "PDC-55 is an ambler class C beta-lactamase from Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-55" EXACT CARD_Short_Name [] [Term] id: ARO:3005040 name: YajC namespace: antibiotic_resistance def: "YajC interacts with the AcrAB-TolC efflux pump in a way that in uncharacterized but is shown to grant increased fitness in the presence of linezolid, rifampicin, and vancomycin." [PMID:31871033] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_antibiotic ARO:0000072 ! linezolid relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: participates_in ARO:3000384 ! AcrAB-TolC synonym: "YajC" EXACT CARD_Short_Name [] [Term] id: ARO:3005041 name: mlaF namespace: antibiotic_resistance def: "mlaF from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaF are shown to confer resistance to linezolid." [PMID:31871033] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3005058 ! mlaFEDB synonym: "mlaF" EXACT CARD_Short_Name [] [Term] id: ARO:3005042 name: mlaD namespace: antibiotic_resistance def: "mlaD from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaD are shown to confer resistance to linezolid." [PMID:31871033] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3005058 ! mlaFEDB synonym: "mlaD" EXACT CARD_Short_Name [] [Term] id: ARO:3005043 name: cmlA9 namespace: antibiotic_resistance def: "cmlA9 is a Major Facilitator Superfamily efflux gene that is found in Salmonella enterica." [PMID:25315365] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000385 ! chloramphenicol synonym: "FloR2" EXACT [] synonym: "cmlA9" EXACT CARD_Short_Name [] [Term] id: ARO:3005044 name: OmpA namespace: antibiotic_resistance def: "OmpA is a porin that confers resistance to beta-lactam antibiotics." [PMID:25341126] is_a: ARO:3004282 ! General Bacterial Porin with reduced permeability to peptide antibiotics relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "OmpA" EXACT CARD_Short_Name [] [Term] id: ARO:3005045 name: SatA namespace: antibiotic_resistance def: "SatA is part of the Streptothricin acetyltransferase gene family. It confers resistance to nucleoside antibiotics." [PMID:12721629] is_a: ARO:3000869 ! streptothricin acetyltransferase (SAT) relationship: confers_resistance_to_antibiotic ARO:0000012 ! streptothricin synonym: "SatA" EXACT CARD_Short_Name [] [Term] id: ARO:3005046 name: MecC-type methicillin resistance repressor MecI namespace: antibiotic_resistance def: "This MecI is a methicillin-resistant repressor resembling MecC. It confers resistance to penams." [PMID:21641281] is_a: ARO:3001208 ! methicillin resistant PBP2 relationship: confers_resistance_to_antibiotic ARO:0000015 ! methicillin synonym: "MecI_rep" EXACT CARD_Short_Name [] [Term] id: ARO:3005047 name: eptB namespace: antibiotic_resistance def: "eptB is a phosphoethanolamine transferase. It confers resistance to peptide antibiotics." [PMID:21629720] is_a: ARO:3004269 ! pmr phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "eptB" EXACT CARD_Short_Name [] [Term] id: ARO:3005049 name: CrcB namespace: antibiotic_resistance def: "CrcB is part of the Camphor Resistance Protein Family. It confers resistance to aminoglycoside antibiotics." [PMID:23405357, PMID:35631066] is_a: ARO:3000112 ! multidrug and toxic compound extrusion (MATE) transporter relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic synonym: "CrcB" EXACT CARD_Short_Name [] [Term] id: ARO:3005050 name: Intrinsic peptide antibiotic resistant Lps namespace: antibiotic_resistance def: "LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins." [PMID:23230287] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3005051 name: LpsB namespace: antibiotic_resistance def: "LpsB is involved in lipopolysaccharide synthesis. It confers intrinsic resistance to colistin and other peptide antibiotics." [PMID:23230287] is_a: ARO:3005050 ! Intrinsic peptide antibiotic resistant Lps relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "LpsB" EXACT CARD_Short_Name [] [Term] id: ARO:3005052 name: LpsA namespace: antibiotic_resistance def: "LpsA plays a role in Lipooligosaccharide biosynthesis. LpsA confers resistance to polymyxin antibiotics." [PMID:32284036, PMID:23980106, PMID:16847057] is_a: ARO:3005050 ! Intrinsic peptide antibiotic resistant Lps relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B relationship: confers_resistance_to_antibiotic ARO:3000693 ! defensin synonym: "LpsA" EXACT CARD_Short_Name [] [Term] id: ARO:3005053 name: ArnT namespace: antibiotic_resistance def: "ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics." [PMID:25341126] is_a: ARO:3004269 ! pmr phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "ArnT" EXACT CARD_Short_Name [] [Term] id: ARO:3005056 name: tet(X6) namespace: antibiotic_resistance def: "Tet(X6) is a tetracycline inactivating enzyme. It is a tet(X) variant." [PMID:32068864] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(X6)" EXACT CARD_Short_Name [] synonym: "tetX6" EXACT [] [Term] id: ARO:3005057 name: tet(X5) namespace: antibiotic_resistance def: "Tet(X5) is a tetracycline inactivating enzyme. It is a variant of tet(X)." [PMID:31611352] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(X5)" EXACT CARD_Short_Name [] synonym: "tetX5" EXACT [] [Term] id: ARO:3005058 name: mlaFEDB namespace: antibiotic_resistance def: "ABC transporter complex which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane." [PMID:19383799, PMID:27529189, PMID:31871033] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_drug_class ARO:3000079 ! oxazolidinone antibiotic [Term] id: ARO:3005059 name: LptD namespace: antibiotic_resistance def: "LptD is involved in LPS transport in a ABC Transporter efflux system. It confers resistance to rifamycin, aminocoumarin, and peptide antibiotics." [PMID:31281307, PMID:22914622] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000111 ! novobiocin relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000454 ! polymyxin B relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic relationship: confers_resistance_to_drug_class ARO:3000103 ! aminocoumarin antibiotic relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic synonym: "LptD" EXACT CARD_Short_Name [] [Term] id: ARO:3005060 name: OXA-837 namespace: antibiotic_resistance def: "A class D OXA-like beta-lactamase described in the emerging pathogen Cupriavidus gilardii." [PMID:31578249] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-837" EXACT CARD_Short_Name [] [Term] id: ARO:3005061 name: AAC(3)-IVb namespace: antibiotic_resistance def: "A novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin." [PMID:31578249] is_a: ARO:3007387 ! AAC(3)-IV relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3004015 ! gentamicin A synonym: "AAC(3)-IVb" EXACT CARD_Short_Name [] synonym: "aacC10" EXACT [] [Term] id: ARO:3005062 name: ANT(3'')-Ib namespace: antibiotic_resistance def: "A novel aminoglycoside 3''-adenyltransferase gene and aminoglycoside resistance gene identified from Cupriavidus gilardii. ANT(3'')-Ib / aadA32 confers resistance to spectinomycin and streptomycin." [PMID:31578249] is_a: ARO:3007407 ! ANT(3'')-I relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin synonym: "ANT(3'')-Ib" EXACT CARD_Short_Name [] synonym: "aadA32" EXACT [] [Term] id: ARO:3005063 name: cprR namespace: antibiotic_resistance def: "cprR is one part of a two-component regulatory system. It with its counterpart cprS induce the Arn operon to confer resistance to peptide antibiotics." [PMID:23006746] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3005065 ! cprRS synonym: "cprR" EXACT CARD_Short_Name [] [Term] id: ARO:3005064 name: cprS namespace: antibiotic_resistance def: "cprS is part of a two-component regulatory system that, with its counterpart cprR, induces the Arn operon in the presence of cationic peptides to confer resistance." [PMID:23006746] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3005065 ! cprRS synonym: "cprS" EXACT CARD_Short_Name [] [Term] id: ARO:3005065 name: cprRS namespace: antibiotic_resistance def: "cprRS is a two-component regulatory system. In the presence of cationic peptides, it induces the Arn operon to confer resistance." [PMID:10984043, PMID:15608211, PMID:23006746, PMID:18978025] is_a: ARO:3004269 ! pmr phosphoethanolamine transferase relationship: regulates ARO:3002985 ! arnA relationship: regulates ARO:3003578 ! PmrF relationship: regulates ARO:3005053 ! ArnT [Term] id: ARO:3005066 name: parRS namespace: antibiotic_resistance def: "parRS is a two-component sensor that mediates MexXY/OprM and porin OprD to confer resistance to polycationic antibiotics. It has multiple mechanisms of resistance such as LPS modification, efflux mediation and reduced porin pathway." [PMID:15608211, PMID:10984043, PMID:21149619, PMID:18978025] is_a: ARO:0010004 ! resistance-nodulation-cell division (RND) antibiotic efflux pump is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3003032 ! MexXY-OprM relationship: regulates ARO:3003686 ! Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem [Term] id: ARO:3005067 name: ParS namespace: antibiotic_resistance def: "ParS is the sensor component of the two-component ParRS system. Alongside its counterpart ParR, it confers resistance to polycationic antibiotics though regulation of efflux pumps and porins." [PMID:10984043, PMID:15608211, PMID:21149619, PMID:18978025] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3005066 ! parRS synonym: "ParS" EXACT CARD_Short_Name [] [Term] id: ARO:3005068 name: ParR namespace: antibiotic_resistance def: "ParR is a component of the two-component sensor ParRS. Alongside its counterpart ParS, it confers resistance to polycationic antibiotics through the regulation of efflux components and porins." [PMID:15608211, PMID:10984043, PMID:21149619, PMID:18978025] is_a: ARO:3000750 ! protein of two-component regulatory system modulating antibiotic efflux relationship: part_of ARO:3005066 ! parRS synonym: "ParR" EXACT CARD_Short_Name [] [Term] id: ARO:3005069 name: rsmA namespace: antibiotic_resistance def: "rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA." [PMID:16622241, PMID:11673439] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux relationship: regulates ARO:3000798 ! MexEF-OprN synonym: "csrA" EXACT [] synonym: "rsmA" EXACT CARD_Short_Name [] [Term] id: ARO:3005070 name: complestatin namespace: antibiotic_resistance def: "A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and inhibited cell wall remodelling during growth." [PMID:32051588] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:16134403 [Term] id: ARO:3005071 name: corbomycin namespace: antibiotic_resistance def: "A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and cell wall remodelling." [PMID:32051588] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:163285731 [Term] id: ARO:3005072 name: ROB-13 namespace: antibiotic_resistance def: "ROB-13 is a beta-lactamase from the blaROB AMR gene family. It was found in Bibersteinia trehalosi." [] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-13" EXACT CARD_Short_Name [] [Term] id: ARO:3005073 name: ROB-3 namespace: antibiotic_resistance def: "ROB-3 is a beta-lactamase from the blaROB AMR gene family. It was found in Moraxella pluranimalium." [] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-3" EXACT CARD_Short_Name [] [Term] id: ARO:3005074 name: ROB-4 namespace: antibiotic_resistance def: "ROB-4 is a beta-lactamase from the blaROB AMR gene family. It was found in Moraxella porci." [] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-4" EXACT CARD_Short_Name [] [Term] id: ARO:3005075 name: ROB-5 namespace: antibiotic_resistance def: "ROB-5 is a class A beta-lactamase from the blaROB AMR gene family. It was found in Moraxella sp. RCAD0137." [] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-5" EXACT CARD_Short_Name [] [Term] id: ARO:3005076 name: ROB-6 namespace: antibiotic_resistance def: "ROB-6 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al." [PMID:26229982] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-6" EXACT CARD_Short_Name [] [Term] id: ARO:3005077 name: ROB-7 namespace: antibiotic_resistance def: "ROB-7 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al." [PMID:26229982] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-7" EXACT CARD_Short_Name [] [Term] id: ARO:3005078 name: ROB-8 namespace: antibiotic_resistance def: "ROB-8 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al." [PMID:26229982] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-8" EXACT CARD_Short_Name [] [Term] id: ARO:3005079 name: ROB-2 namespace: antibiotic_resistance def: "ROB-2 is an extended spectrum class A beta-lactamase from the blaROB AMR gene family It is described by Kadlec et al." [PMID:30561662] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-2" EXACT CARD_Short_Name [] [Term] id: ARO:3005080 name: ROB-10 namespace: antibiotic_resistance def: "ROB-10 is a class A beta-lactamase from the blaROB AMR gene family. It was found in Glaesserella parasuis." [] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-10" EXACT CARD_Short_Name [] [Term] id: ARO:3005081 name: Thermus thermophilus uL3 mutations conferring resistance to pleuromutilin antibiotics namespace: antibiotic_resistance def: "Thermus thermophilus ribosomal protein uL3 containing various mutations conferring resistance to tiamulin. Mutations in the ribosomal protein of uL3 acts by interfering with local rRNA conformation thus conferring resistance." [PMID:32526926] is_a: ARO:3005082 ! Ribosomal protein mutation conferring resistance to pleuromutilin antibiotics relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin synonym: "Tthe_uL3_PLM" EXACT CARD_Short_Name [] [Term] id: ARO:3005082 name: Ribosomal protein mutation conferring resistance to pleuromutilin antibiotics namespace: antibiotic_resistance def: "Ribosomal protein mutations that interfere with the rRNA conformation at the active site thus conferring antibiotic resistance." [PMID:32526926] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3000670 ! pleuromutilin antibiotic [Term] id: ARO:3005083 name: Thermus thermophilus 23s rRNA conferring resistance to pleuromutilin antibiotics namespace: antibiotic_resistance def: "Mutations in the 23s rRNA of Thermus thermophilus confers resistance to pleuromutilin antibiotics such as tiamulin." [PMID:32526926] is_a: ARO:3004178 ! 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin synonym: "Tthe_23S_PLM" EXACT CARD_Short_Name [] [Term] id: ARO:3005084 name: dfrA31 namespace: antibiotic_resistance def: "dfrA31 is an antibiotic resistance dihydrofolate reductase from an integron found from Vibrio cholerae." [PMID:22782487, PMID:23162539] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA31" EXACT CARD_Short_Name [] [Term] id: ARO:3005085 name: AAC(3)-IIg namespace: antibiotic_resistance def: "AAC(3)-IIg is part of the AAC(3) family. It was initially found in clinical isolates of Enterobacter cloacae." [PMID:32571822] is_a: ARO:3007385 ! AAC(3)-II relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007377 ! 6'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "AAC(3)-IIg" EXACT CARD_Short_Name [] [Term] id: ARO:3005086 name: Target protecting FusB-type protein conferring resistance to Fusidic acid namespace: antibiotic_resistance def: "Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid." [PMID:22308410, PMID:26781961, PMID:21968364] is_a: ARO:3000185 ! antibiotic target protection protein relationship: confers_resistance_to_drug_class ARO:3007153 ! fusidane antibiotic [Term] id: ARO:3005087 name: msrF namespace: antibiotic_resistance def: "msrF is an ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics." [PMID:32122903] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "msrF" EXACT CARD_Short_Name [] [Term] id: ARO:3005088 name: msrH namespace: antibiotic_resistance def: "msrH is a ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics." [PMID:32122903] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "msrH" EXACT CARD_Short_Name [] [Term] id: ARO:3005089 name: mef(D) namespace: antibiotic_resistance def: "mef(D) is a major facilitator superfamily efflux pump protein. It works together with the msr proteins to confer resistance to macrolide antibiotics." [PMID:32122903] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic synonym: "mef(D)" EXACT CARD_Short_Name [] [Term] id: ARO:3005090 name: RanB namespace: antibiotic_resistance def: "RanB is the determinant of antibiotic resistance within the RanARanB ABC-type efflux system. It confers resistance to aminoglycoside antibiotics." [PMID:32273020] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3005092 ! RanARanB synonym: "RanB" EXACT CARD_Short_Name [] [Term] id: ARO:3005091 name: RanA namespace: antibiotic_resistance def: "RanA is a part of the RanARanB ABC-type efflux system. Alongside RanB, it confers resistance to aminoglycoside antibiotics." [PMID:32273020] is_a: ARO:3000748 ! subunit of efflux pump conferring antibiotic resistance relationship: part_of ARO:3005092 ! RanARanB synonym: "RanA" EXACT CARD_Short_Name [] [Term] id: ARO:3005092 name: RanARanB namespace: antibiotic_resistance def: "RanARanB is the combination of both RanA and RanB to form an ABC-type efflux system. RanB confers resistance to aminoglycoside antibiotics." [PMID:32273020] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3005093 name: OXA-899 namespace: antibiotic_resistance def: "OXA-899 is a class D beta-lactamase and part of the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii." [PMID:32169680] is_a: ARO:3007708 ! OXA-22-like beta-lactamase synonym: "OXA-899" EXACT CARD_Short_Name [] [Term] id: ARO:3005094 name: OXA-898 namespace: antibiotic_resistance def: "OXA-898 is a class D beta-lactamase from the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii." [PMID:32169680] is_a: ARO:3007729 ! OXA-60-like beta-lactamase synonym: "OXA-898" EXACT CARD_Short_Name [] [Term] id: ARO:3005095 name: GPC beta-lactamase namespace: antibiotic_resistance def: "GPC is a class A beta-lactamase family. It is found initially in Pseudomonas aeruginosa. It confers resistance to B-lactams." [PMID:31960033] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005096 name: GPC-1 namespace: antibiotic_resistance def: "GPC-1 is a class A beta-lactamase. It is part of the GPC beta-lactamase gene family. Originally found in Pseudomonas aeruginosa. Confers resistance to B-lactams." [PMID:31960033] is_a: ARO:3005095 ! GPC beta-lactamase synonym: "GPC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3005097 name: mecC-type BlaZ namespace: antibiotic_resistance def: "A blaZ-like beta-lactamase found in S. Aureus." [PMID:21636525] is_a: ARO:3004197 ! BlaZ beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000054 ! penicillin synonym: "mecC-type_BlaZ" EXACT CARD_Short_Name [] [Term] id: ARO:3005098 name: qacL namespace: antibiotic_resistance def: "A subunit of the qac multidrug efflux pump in Vibrio cholerae." [PMID:16801431] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics synonym: "qacL" EXACT CARD_Short_Name [] [Term] id: ARO:3005099 name: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) namespace: antibiotic_resistance def: "Variant of ErmA (ARO:3000347) found in Streptococcus pyogenes. Confers the MLSb phenotype." [PMID:9527769] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Spyo_ErmA_MLSb" EXACT CARD_Short_Name [] synonym: "ermTR" EXACT [] [Term] id: ARO:3005100 name: FosB2 namespace: antibiotic_resistance def: "Subtype of FosB (ARO:3000172). Present in multiple species." [PMID:12721629] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosB2" EXACT CARD_Short_Name [] [Term] id: ARO:3005101 name: prothionamide resistant katG namespace: antibiotic_resistance def: "Mutations associated with katG conferring resistance to prothionamide, an analogue of isoniazid. Like isoniazid, prothionamide targets lnhA." [PMID:30583053] is_a: ARO:3004266 ! antibiotic resistant katG relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3005102 name: Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide namespace: antibiotic_resistance def: "Mutations in Mycobacterium tuberculosis katG conferring resistance to prothionamide, an analogue of isoniazid." [PMID:30583053] is_a: ARO:3005101 ! prothionamide resistant katG relationship: confers_resistance_to_antibiotic ARO:3004025 ! prothionamide synonym: "Mtub_katG_PTO" EXACT CARD_Short_Name [] [Term] id: ARO:3005103 name: isoniazid resistant ethA namespace: antibiotic_resistance def: "Mutations in ethA conferring resistance to isoniazid." [PMID:30583053] is_a: ARO:3003456 ! antibiotic resistant ethA relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic [Term] id: ARO:3005104 name: prothionamide resistant ethA namespace: antibiotic_resistance def: "Mutations in ethA conferring resistance to prothionamide, an analogue of isoniazid." [PMID:30583053] is_a: ARO:3003456 ! antibiotic resistant ethA relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3005105 name: Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid namespace: antibiotic_resistance def: "Mutations in Mycobacterium tuberculosis ethA conferring resistance to isoniazid." [PMID:30583053, PMID:19486070] is_a: ARO:3005103 ! isoniazid resistant ethA relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid synonym: "Mtub_ethA_INH" EXACT CARD_Short_Name [] [Term] id: ARO:3005106 name: Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide namespace: antibiotic_resistance def: "Mutations in Mycobacterium tuberculosis ethA conferring resistance to prothionamide, an analogue to isoniazid." [PMID:30583053] is_a: ARO:3005104 ! prothionamide resistant ethA relationship: confers_resistance_to_antibiotic ARO:3004025 ! prothionamide synonym: "Mtub_ethA_PTO" EXACT CARD_Short_Name [] [Term] id: ARO:3005107 name: prothionamide resistant mshA namespace: antibiotic_resistance def: "Mutations in mshA conferring resistance to prothionamide, an analogue of isoniazid." [] is_a: ARO:3004900 ! antibiotic resistant mshA relationship: confers_resistance_to_drug_class ARO:3007156 ! thioamide antibiotic [Term] id: ARO:3005108 name: Mycobacterium tuberculosis mshA mutations conferring resistance to prothionamide namespace: antibiotic_resistance def: "Mutations in Mycobacterium tuberculosis mshA conferring resistance to prothionamide, an analogue to isoniazid." [PMID:30583053] is_a: ARO:3005107 ! prothionamide resistant mshA relationship: confers_resistance_to_antibiotic ARO:3004025 ! prothionamide synonym: "Mtub_mshA_PTO" EXACT CARD_Short_Name [] [Term] id: ARO:3005110 name: blaS namespace: antibiotic_resistance def: "A class A beta-lactamase in Mycolicibacterium smegmatis." [PMID:15699201, PMID:9103972] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3005111 name: blaS1 namespace: antibiotic_resistance def: "Predominant beta-lactamase in Mycolicibacterium smegmatis." [PMID:9103972, PMID:15699201] is_a: ARO:3005110 ! blaS relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000043 ! carbenicillin relationship: confers_resistance_to_antibiotic ARO:0000056 ! oxacillin relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000639 ! mezlocillin relationship: confers_resistance_to_antibiotic ARO:3000646 ! cefixime synonym: "blaS1" EXACT CARD_Short_Name [] [Term] id: ARO:3005112 name: AAC(6')-Ib-cr3 namespace: antibiotic_resistance def: "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Aeromonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics." [PMID:25691640] is_a: ARO:3005113 ! AAC(6')-Ib-cr relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-cr3" EXACT CARD_Short_Name [] [Term] id: ARO:3005113 name: AAC(6')-Ib-cr namespace: antibiotic_resistance def: "A subfamily of aminoglycoside 6'-N-acetyltransferases, AAC(6'), which doubly confer resistance to aminoglycoside and fluoroquinolone antibiotics through fluoroquinolone-acetylating activity." [] is_a: ARO:3000345 ! AAC(6') relationship: confers_resistance_to_drug_class ARO:0000001 ! fluoroquinolone antibiotic relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3005114 name: AAC(6')-Ib-cr4 namespace: antibiotic_resistance def: "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Enterobacter. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics." [PMID:23361643] is_a: ARO:3005113 ! AAC(6')-Ib-cr relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-cr4" EXACT CARD_Short_Name [] [Term] id: ARO:3005115 name: AAC(6')-Ib-cr5 namespace: antibiotic_resistance def: "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Pseudomonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics." [PMID:34909689] is_a: ARO:3005113 ! AAC(6')-Ib-cr relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-cr5" EXACT CARD_Short_Name [] [Term] id: ARO:3005116 name: AAC(6')-Ib-cr6 namespace: antibiotic_resistance def: "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Escherichia coli. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics." [PMID:33295867] is_a: ARO:3005113 ! AAC(6')-Ib-cr relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-cr6" EXACT CARD_Short_Name [] [Term] id: ARO:3005117 name: AAC(6')-Ib-cr7 namespace: antibiotic_resistance def: "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Klebsiella. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics." [PMID:25691640] is_a: ARO:3005113 ! AAC(6')-Ib-cr relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-cr7" EXACT CARD_Short_Name [] [Term] id: ARO:3005118 name: AAC(6')-Ib-cr8 namespace: antibiotic_resistance def: "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant, identified from Salmonella. These variants confers resistance to both aminoglycoside and fluoroquinolone antibiotics." [] is_a: ARO:3005113 ! AAC(6')-Ib-cr relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-cr8" EXACT CARD_Short_Name [] [Term] id: ARO:3005119 name: AAC(6')-Ib-cr9 namespace: antibiotic_resistance def: "A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant, identified from Serratia. These variants confers resistance to both aminoglycoside and fluoroquinolone antibiotics." [] is_a: ARO:3005113 ! AAC(6')-Ib-cr relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin synonym: "AAC(6')-Ib-cr9" EXACT CARD_Short_Name [] [Term] id: ARO:3005120 name: levonadifloxacin namespace: antibiotic_resistance def: "A novel broad-spectrum anti-MRSA benzoquinolizine antibiotic effective against gram-positive and gram-negative pathogens." [PMID:31920285] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:9850038 [Term] id: ARO:3005121 name: lsaD namespace: antibiotic_resistance def: "The lsa(D) gene represents an ABC-F subfamily protein expressed in Lactococcus garvieae. It confers resistance to Streptogramins A, Pleuromutilins and Lincosamides." [PMID:32706619] is_a: ARO:3004472 ! lsa-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin synonym: "lsa(D)" EXACT [] synonym: "lsaD" EXACT CARD_Short_Name [] [Term] id: ARO:3005122 name: PDC-68 namespace: antibiotic_resistance def: "PDC-68 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-68" EXACT CARD_Short_Name [] [Term] id: ARO:3005123 name: PDC-70 namespace: antibiotic_resistance def: "PDC-70 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-70" EXACT CARD_Short_Name [] [Term] id: ARO:3005124 name: PDC-63 namespace: antibiotic_resistance def: "PDC-63 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-63" EXACT CARD_Short_Name [] [Term] id: ARO:3005125 name: PDC-57 namespace: antibiotic_resistance def: "PDC-57 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-57" EXACT CARD_Short_Name [] [Term] id: ARO:3005126 name: PDC-66 namespace: antibiotic_resistance def: "PDC-66 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-66" EXACT CARD_Short_Name [] [Term] id: ARO:3005127 name: PDC-14 namespace: antibiotic_resistance def: "PDC-14 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-14" EXACT CARD_Short_Name [] [Term] id: ARO:3005128 name: PDC-47 namespace: antibiotic_resistance def: "PDC-47 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-47" EXACT CARD_Short_Name [] [Term] id: ARO:3005129 name: PDC-51 namespace: antibiotic_resistance def: "PDC-51 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-51" EXACT CARD_Short_Name [] [Term] id: ARO:3005130 name: OXA-846 namespace: antibiotic_resistance def: "OXA-846 is a class D beta-lactamase found in Pseudomonas aeruginosa. It is part of the OXA-50 family of oxacillin-hydrolyzing beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-846" EXACT CARD_Short_Name [] [Term] id: ARO:3005131 name: NDM-29 namespace: antibiotic_resistance def: "An NDM metallo-beta-lactamase variant reported in Klebsiella pneumoniae. Sourced from NCBI's Pathogen Reference Gene Browser; no peer-reviewed article." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-29" EXACT CARD_Short_Name [] [Term] id: ARO:3005132 name: PDC-11 namespace: antibiotic_resistance def: "PDC-11 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-11" EXACT CARD_Short_Name [] [Term] id: ARO:3005133 name: PDC-62 namespace: antibiotic_resistance def: "PDC-62 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-62" EXACT CARD_Short_Name [] [Term] id: ARO:3005134 name: PDC-43 namespace: antibiotic_resistance def: "PDC-43 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-43" EXACT CARD_Short_Name [] [Term] id: ARO:3005135 name: PDC-54 namespace: antibiotic_resistance def: "PDC-54 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-54" EXACT CARD_Short_Name [] [Term] id: ARO:3005136 name: OXA-906 namespace: antibiotic_resistance def: "OXA-906 is a class D beta-lactamase from the OXA-50 family found in Pseudomonas aeruginosa." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-906" EXACT CARD_Short_Name [] [Term] id: ARO:3005137 name: PDC-59 namespace: antibiotic_resistance def: "PDC-59 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-59" EXACT CARD_Short_Name [] [Term] id: ARO:3005138 name: OXA-850 namespace: antibiotic_resistance def: "Pseudomonas aeruginosa strain OXA-50 family oxacillin-hydrolyzing class D beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-850" EXACT CARD_Short_Name [] [Term] id: ARO:3005139 name: PDC-67 namespace: antibiotic_resistance def: "PDC-67 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 5065." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-67" EXACT CARD_Short_Name [] [Term] id: ARO:3005140 name: PDC-56 namespace: antibiotic_resistance def: "PDC-56 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 4883." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-56" EXACT CARD_Short_Name [] [Term] id: ARO:3005141 name: PDC-52 namespace: antibiotic_resistance def: "PDC-52 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-52" EXACT CARD_Short_Name [] [Term] id: ARO:3005142 name: PDC-44 namespace: antibiotic_resistance def: "PDC-44 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-44" EXACT CARD_Short_Name [] [Term] id: ARO:3005143 name: PDC-240 namespace: antibiotic_resistance def: "PDC-240 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-240" EXACT CARD_Short_Name [] [Term] id: ARO:3005144 name: PDC-61 namespace: antibiotic_resistance def: "PDC-61 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-61" EXACT CARD_Short_Name [] [Term] id: ARO:3005145 name: PDC-45 namespace: antibiotic_resistance def: "PDC-45 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-45" EXACT CARD_Short_Name [] [Term] id: ARO:3005146 name: PDC-49 namespace: antibiotic_resistance def: "PDC-49 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-49" EXACT CARD_Short_Name [] [Term] id: ARO:3005147 name: PDC-50 namespace: antibiotic_resistance def: "PDC-50 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-50" EXACT CARD_Short_Name [] [Term] id: ARO:3005148 name: PDC-48 namespace: antibiotic_resistance def: "PDC-48 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-48" EXACT CARD_Short_Name [] [Term] id: ARO:3005149 name: PAC beta-lactamase namespace: antibiotic_resistance def: "PAC beta-lactamase is an inhibitior-resistant cephalosporin-hydrolyzing class C beta-lactamase." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005150 name: PAC-1 namespace: antibiotic_resistance def: "PAC-1 is an ambler class C beta-lactamase from the PAC beta-lactamase family. It is found in Pseudomonas aeruginosa." [] is_a: ARO:3005149 ! PAC beta-lactamase synonym: "PAC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3005151 name: PDC-53 namespace: antibiotic_resistance def: "PDC-53 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-53" EXACT CARD_Short_Name [] [Term] id: ARO:3005152 name: PDC-72 namespace: antibiotic_resistance def: "PDC-72 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-72" EXACT CARD_Short_Name [] [Term] id: ARO:3005153 name: PDC-69 namespace: antibiotic_resistance def: "PDC-69 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-69" EXACT CARD_Short_Name [] [Term] id: ARO:3005155 name: PDC-23 namespace: antibiotic_resistance def: "PDC-23 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-23" EXACT CARD_Short_Name [] [Term] id: ARO:3005156 name: PDC-28 namespace: antibiotic_resistance def: "PDC-28 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-28" EXACT CARD_Short_Name [] [Term] id: ARO:3005157 name: PDC-41 namespace: antibiotic_resistance def: "PDC-41 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa." [PMID:25022578] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-41" EXACT CARD_Short_Name [] [Term] id: ARO:3005158 name: OXA-668 namespace: antibiotic_resistance def: "OXA-668 is a class D beta-lactamase from the OXA-274 family of OXA beta-lactamases." [] is_a: ARO:3007713 ! OXA-274-like beta-lactamase synonym: "OXA-668" EXACT CARD_Short_Name [] [Term] id: ARO:3005159 name: OXA-818 namespace: antibiotic_resistance def: "OXA-818 is a class D beta-lactamase from the OXA-23 family of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-818" EXACT CARD_Short_Name [] [Term] id: ARO:3005160 name: OXA-812 namespace: antibiotic_resistance def: "OXA-812 is a class D beta-lactamase from the OXA-23 family of OXA beta-lactamases." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-812" EXACT CARD_Short_Name [] [Term] id: ARO:3005162 name: FosA7.5 namespace: antibiotic_resistance def: "FosA7.5 is a variant of the FosA7 gene. This gene is unique from FosA7 in that it is found in Escherichia coli as opposed to Salmonella enterica. It confers resistance to fosfomycin." [PMID:33077665] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosA7.5" EXACT CARD_Short_Name [] [Term] id: ARO:3005163 name: ionophore with antibiotic activity namespace: antibiotic_resistance def: "Ionophores are chemical entities which reversibly bind ions. Many ionophores display antibacterial and antifungal properties. An ionophore will bind and transport ions through a cell membrane, thereby potentially disrupting membrane potential and modifying permeability." [PMID:22849267] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3005164 name: dfrA35 namespace: antibiotic_resistance def: "dfrA35 is a trimethoprim resistant dihydrofolate reductase gene found in the lncC plasmid pEc158 from E.coli." [PMID:30989199] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrA35" EXACT CARD_Short_Name [] [Term] id: ARO:3005165 name: antibiotic drug class namespace: antibiotic_resistance def: "In an antimicrobial context, a drug class is a set of antibiotic molecules, including antibiotic/adjuvant combination medications, with similar chemical structures, molecular targets, and/or modes and mechanisms of action." [] is_a: ARO:3004299 ! antimicrobial phenotype [Term] id: ARO:3005166 name: tet(X1) namespace: antibiotic_resistance def: "Tetracycline resistance gene tet(X) ortholog described by Fang et al. 2020." [PMID:32567703] is_a: ARO:3000036 ! tetracycline inactivation enzyme relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3000152 ! minocycline relationship: confers_resistance_to_antibiotic ARO:3000668 ! oxytetracycline synonym: "tet(X1)" EXACT CARD_Short_Name [] synonym: "tetX1" EXACT [] [Term] id: ARO:3005167 name: quinone with antibiotic activity namespace: antibiotic_resistance def: "A class of organic compounds derived from aromatic compounds and exhibiting antibiotic activity." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3005168 name: ansamycin antibiotic namespace: antibiotic_resistance def: "A class of compounds containing an aromatic moiety and an aliphatic chain, produced as a bacterial metabolite and exhibiting antibiotic properties to many gram-positive pathogens." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3005169 name: alkaloids with antibiotic activity namespace: antibiotic_resistance def: "Alkaloids are naturally occurring organic compounds containing the element nitrogen. Some alkaloid compounds exhibit specific antibacterial activity." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3005170 name: metallophores with antibiotic activity namespace: antibiotic_resistance def: "A metallophore is any organic substance capable of carrying a metallic element such as zinc or iron, typically through chelation. Some metallophores exhibit specific antibiotic activity." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3005171 name: polyketide with antibiotic activity namespace: antibiotic_resistance def: "Polyketides are a large group of secondary metabolites. Some polyketide compounds have been shown to possess antibiotic activity and qualities." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3005172 name: terpene with antibiotic activity namespace: antibiotic_resistance def: "Terpenes are a large class of naturally produced organic compounds, predominantly produced by plants such as conifers. Some terpenes have been shown to possess antibiotic qualities or activity." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3005174 name: thiacalixarene derivatives namespace: antibiotic_resistance def: "Derivatives of thiacalixarene exhibit antiseptic and antibacterial activity." [PMID:33310546] is_a: ARO:3005386 ! disinfecting agents and antiseptics xref: pubchem.compound:335377 [Term] id: ARO:3005175 name: perchlozone namespace: antibiotic_resistance def: "Perchlozone is a novel thiosemicarbazone used for the treatment of multidrug-resistant tuberculosis. It is similar to thiacetazone with only a different side chain attached to the thiosemicarbazone moiety. Perchlozone is a prodrug that is activated by ethA and inhibits the HadABC complex." [PMID:33022959, PMID:25704063] is_a: ARO:3007161 ! thiosemicarbazone antibiotic synonym: "4-thioureido-iminomethylpyridinium perchlorate" EXACT [] xref: pubchem.compound:5374694 [Term] id: ARO:3005176 name: CMY-158 namespace: antibiotic_resistance def: "CMY-158 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 06-NOV-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-158" EXACT CARD_Short_Name [] [Term] id: ARO:3005177 name: CMY-173 namespace: antibiotic_resistance def: "CMY-173 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-SEP-2020." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-173" EXACT CARD_Short_Name [] [Term] id: ARO:3005178 name: Mycobacterium tuberculosis ethA mutations conferring resistance to perchlozone namespace: antibiotic_resistance def: "Mutations in ethA conferring resistance to perchlozone, a novel thiosemicarbazone." [PMID:33022959] is_a: ARO:3005205 ! perchlozone resistant ethA relationship: confers_resistance_to_antibiotic ARO:3005175 ! perchlozone synonym: "Mtub_ethA_PCL" EXACT CARD_Short_Name [] [Term] id: ARO:3005180 name: CMY-147 namespace: antibiotic_resistance def: "CMY-147 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-FEB-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-147" EXACT CARD_Short_Name [] [Term] id: ARO:3005181 name: CMY-146 namespace: antibiotic_resistance def: "CMY-146 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-JAN-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-146" EXACT CARD_Short_Name [] [Term] id: ARO:3005182 name: CMY-156 namespace: antibiotic_resistance def: "CMY-156 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 14-FEB-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-156" EXACT CARD_Short_Name [] [Term] id: ARO:3005183 name: CMY-160 namespace: antibiotic_resistance def: "CMY-160 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 29-MAY-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-160" EXACT CARD_Short_Name [] [Term] id: ARO:3005184 name: CMY-162 namespace: antibiotic_resistance def: "CMY-162 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 21-JUN-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-162" EXACT CARD_Short_Name [] [Term] id: ARO:3005185 name: CMY-140 namespace: antibiotic_resistance def: "CMY-140 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-JUN-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-140" EXACT CARD_Short_Name [] [Term] id: ARO:3005186 name: CMY-164 namespace: antibiotic_resistance def: "CMY-164 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 26-JUN-2019." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-164" EXACT CARD_Short_Name [] [Term] id: ARO:3005187 name: CMY-161 namespace: antibiotic_resistance def: "CMY-161 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 24-MAY-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-161" EXACT CARD_Short_Name [] [Term] id: ARO:3005188 name: CMY-165 namespace: antibiotic_resistance def: "CMY-165 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-AUG-2019." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-165" EXACT CARD_Short_Name [] [Term] id: ARO:3005189 name: CMY-166 namespace: antibiotic_resistance def: "CMY-166 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-AUG-2019." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-166" EXACT CARD_Short_Name [] [Term] id: ARO:3005190 name: CMY-149 namespace: antibiotic_resistance def: "CMY-149 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-MAY-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-149" EXACT CARD_Short_Name [] [Term] id: ARO:3005191 name: CMY-139 namespace: antibiotic_resistance def: "CMY-139 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-139" EXACT CARD_Short_Name [] [Term] id: ARO:3005192 name: CMY-148 namespace: antibiotic_resistance def: "CMY-148 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-MAY-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-148" EXACT CARD_Short_Name [] [Term] id: ARO:3005193 name: CMY-163 namespace: antibiotic_resistance def: "CMY-163 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 25-JUN-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-163" EXACT CARD_Short_Name [] [Term] id: ARO:3005194 name: CMY-154 namespace: antibiotic_resistance def: "CMY-154 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 21-JUN-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-154" EXACT CARD_Short_Name [] [Term] id: ARO:3005195 name: CMY-142 namespace: antibiotic_resistance def: "CMY-142 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 05-JUN-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-142" EXACT CARD_Short_Name [] [Term] id: ARO:3005196 name: CMY-141 namespace: antibiotic_resistance def: "CMY-141 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-JUN-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-141" EXACT CARD_Short_Name [] [Term] id: ARO:3005197 name: CMY-145 namespace: antibiotic_resistance def: "CMY-145 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-JAN-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-145" EXACT CARD_Short_Name [] [Term] id: ARO:3005198 name: CMY-157 namespace: antibiotic_resistance def: "CMY-96 is a beta-lactamase found in Citrobacter sp. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-NOV-2018." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-157" EXACT CARD_Short_Name [] [Term] id: ARO:3005199 name: CMY-171 namespace: antibiotic_resistance def: "CMY-171 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 14-APR-2020." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-171" EXACT CARD_Short_Name [] [Term] id: ARO:3005200 name: CMY-155 namespace: antibiotic_resistance def: "CMY-155 is a beta-lactamase found in Klebsiella sp. KF07. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-AUG-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-155" EXACT CARD_Short_Name [] [Term] id: ARO:3005201 name: bispicen namespace: antibiotic_resistance def: "An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor." [PMID:33285370] is_a: ARO:3007133 ! polypyridine metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002272 ! VIM-2 synonym: "N,N'-bis(2-pyridylmethyl)-ethylenediamine" EXACT [] xref: pubchem.compound:10890081 [Term] id: ARO:3005202 name: trispicen namespace: antibiotic_resistance def: "An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor." [PMID:33285370] is_a: ARO:3007133 ! polypyridine metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000582 ! L1 beta-lactamase relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002272 ! VIM-2 synonym: "N,N,N'-tris(2-pyridylmethyl)-ethylenediamine" EXACT [] xref: pubchem.compound:15845745 [Term] id: ARO:3005204 name: CMY-143 namespace: antibiotic_resistance def: "CMY-143 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 16-NOV-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-143" EXACT CARD_Short_Name [] [Term] id: ARO:3005205 name: perchlozone resistant ethA namespace: antibiotic_resistance def: "Genetic variants of ethA from Mycobacterium spp. including tuberculosis, which confer resistance to the antibiotic perchlozone." [] is_a: ARO:3003456 ! antibiotic resistant ethA relationship: confers_resistance_to_drug_class ARO:3007161 ! thiosemicarbazone antibiotic [Term] id: ARO:3005207 name: SHV-205 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-Nov-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-205" EXACT CARD_Short_Name [] [Term] id: ARO:3005208 name: SHV-222 namespace: antibiotic_resistance def: "A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-222" EXACT CARD_Short_Name [] [Term] id: ARO:3005209 name: SHV-198 namespace: antibiotic_resistance def: "A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 10-AGU-2017." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-198" EXACT CARD_Short_Name [] [Term] id: ARO:3005210 name: SHV-195 namespace: antibiotic_resistance def: "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-195" EXACT CARD_Short_Name [] [Term] id: ARO:3005211 name: SHV-201 namespace: antibiotic_resistance def: "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-201" EXACT CARD_Short_Name [] [Term] id: ARO:3005212 name: SHV-212 namespace: antibiotic_resistance def: "A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-212" EXACT CARD_Short_Name [] [Term] id: ARO:3005213 name: SHV-204 namespace: antibiotic_resistance def: "A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 26-JUN-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-204" EXACT CARD_Short_Name [] [Term] id: ARO:3005214 name: SHV-197 namespace: antibiotic_resistance def: "A beta-lactamase gene from Escherichia coli. Directly submitted to NCBI without publication on 05-JAN-2017." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-197" EXACT CARD_Short_Name [] [Term] id: ARO:3005215 name: SHV-216 namespace: antibiotic_resistance def: "A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-216" EXACT CARD_Short_Name [] [Term] id: ARO:3005216 name: CMY-152 namespace: antibiotic_resistance def: "CMY-152 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 25-APR-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-152" EXACT CARD_Short_Name [] [Term] id: ARO:3005217 name: CMY-151 namespace: antibiotic_resistance def: "CMY-151 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 17-MAR-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-151" EXACT CARD_Short_Name [] [Term] id: ARO:3005218 name: CMY-153 namespace: antibiotic_resistance def: "CMY-89 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-MAY-2017." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-153" EXACT CARD_Short_Name [] [Term] id: ARO:3005219 name: CMY-144 namespace: antibiotic_resistance def: "CMY-144 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-NOV-2016." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-144" EXACT CARD_Short_Name [] [Term] id: ARO:3005220 name: CMY-138 namespace: antibiotic_resistance def: "CMY-138 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 04-NOV-2015." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-138" EXACT CARD_Short_Name [] [Term] id: ARO:3005221 name: MCR-3.41 namespace: antibiotic_resistance def: "Novel mcr-3.41 gene identified in an Aeromonas veronii C198 isolate from a patient with Septicemia in Thailand by Hatrongjit et. al." [PMID:33317051] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.41" EXACT CARD_Short_Name [] [Term] id: ARO:3005222 name: OXA-544 namespace: antibiotic_resistance def: "OXA-544 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-544" EXACT CARD_Short_Name [] [Term] id: ARO:3005223 name: SHV-194 namespace: antibiotic_resistance def: "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 04-AUG-2016." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-194" EXACT CARD_Short_Name [] [Term] id: ARO:3005224 name: SHV-220 namespace: antibiotic_resistance def: "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-220" EXACT CARD_Short_Name [] [Term] id: ARO:3005225 name: SHV-210 namespace: antibiotic_resistance def: "Beta-lactamase gene from Klebsiella pneumoniae. Directed submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-210" EXACT CARD_Short_Name [] [Term] id: ARO:3005226 name: SHV-208 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly added to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-208" EXACT CARD_Short_Name [] [Term] id: ARO:3005227 name: SHV-206 namespace: antibiotic_resistance def: "A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-206" EXACT CARD_Short_Name [] [Term] id: ARO:3005228 name: SHV-226 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-226" EXACT CARD_Short_Name [] [Term] id: ARO:3005229 name: SHV-196 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 19-SEP-2016." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-196" EXACT CARD_Short_Name [] [Term] id: ARO:3005230 name: SHV-211 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 7-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-211" EXACT CARD_Short_Name [] [Term] id: ARO:3005231 name: SHV-219 namespace: antibiotic_resistance def: "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-219" EXACT CARD_Short_Name [] [Term] id: ARO:3005232 name: SHV-199 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Escherichia coli. Directly submitted to NCBI without publication on 10-AUG-2017." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-199" EXACT CARD_Short_Name [] [Term] id: ARO:3005233 name: SHV-227 namespace: antibiotic_resistance def: "Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-227" EXACT CARD_Short_Name [] [Term] id: ARO:3005234 name: SHV-223 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumonia. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-223" EXACT CARD_Short_Name [] [Term] id: ARO:3005235 name: SHV-214 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-214" EXACT CARD_Short_Name [] [Term] id: ARO:3005236 name: SHV-207 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella penumoniae. Directly submitted to NCBI without publications on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-207" EXACT CARD_Short_Name [] [Term] id: ARO:3005237 name: SHV-1b-b namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 08-JUN-2016." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-1b-b" EXACT CARD_Short_Name [] [Term] id: ARO:3005238 name: SHV-218 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-218" EXACT CARD_Short_Name [] [Term] id: ARO:3005239 name: SHV-193 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 08-JUN-2016." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-193" EXACT CARD_Short_Name [] [Term] id: ARO:3005240 name: SHV-224 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-224" EXACT CARD_Short_Name [] [Term] id: ARO:3005241 name: SHV-225 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-225" EXACT CARD_Short_Name [] [Term] id: ARO:3005242 name: SHV-209 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-209" EXACT CARD_Short_Name [] [Term] id: ARO:3005243 name: SHV-215 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-215" EXACT CARD_Short_Name [] [Term] id: ARO:3005244 name: ADC-181 namespace: antibiotic_resistance def: "ADC ortholog described by Nodari et al. 2020." [PMID:33329450] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC 181" EXACT [] synonym: "ADC-181" EXACT CARD_Short_Name [] [Term] id: ARO:3005245 name: ADC-182 namespace: antibiotic_resistance def: "ADC ortholog described by Nodari et al. 2020." [PMID:33329450] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC 182" EXACT [] synonym: "ADC-182" EXACT CARD_Short_Name [] [Term] id: ARO:3005246 name: ADC-183 namespace: antibiotic_resistance def: "ADC ortholog described by Nodari et al. 2020." [PMID:33329450] is_a: ARO:3003846 ! ADC beta-lactamase without carbapenemase activity synonym: "ADC 183" EXACT [] synonym: "ADC-183" EXACT CARD_Short_Name [] [Term] id: ARO:3005247 name: SHV-228 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-228" EXACT CARD_Short_Name [] [Term] id: ARO:3005248 name: SHV-200 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 21-DEC-2017." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-200" EXACT CARD_Short_Name [] [Term] id: ARO:3005249 name: SHV-203 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 21-DEC-2017." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-203" EXACT CARD_Short_Name [] [Term] id: ARO:3005250 name: SHV-217 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-217" EXACT CARD_Short_Name [] [Term] id: ARO:3005251 name: SHV-213 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-213" EXACT CARD_Short_Name [] [Term] id: ARO:3005252 name: SHV-221 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumonia. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-221" EXACT CARD_Short_Name [] [Term] id: ARO:3005253 name: SHV-202 namespace: antibiotic_resistance def: "A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018." [] is_a: ARO:3000015 ! SHV beta-lactamase synonym: "SHV-202" EXACT CARD_Short_Name [] [Term] id: ARO:3005255 name: TEM-224 namespace: antibiotic_resistance def: "TEM-224 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-224" EXACT CARD_Short_Name [] [Term] id: ARO:3005256 name: TEM-225 namespace: antibiotic_resistance def: "TEM-225 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-225" EXACT CARD_Short_Name [] [Term] id: ARO:3005257 name: TEM-226 namespace: antibiotic_resistance def: "TEM-226 is a beta lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-226" EXACT CARD_Short_Name [] [Term] id: ARO:3005258 name: TEM-227 namespace: antibiotic_resistance def: "TEM-227 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-227" EXACT CARD_Short_Name [] [Term] id: ARO:3005259 name: TEM-228 namespace: antibiotic_resistance def: "TEM-228 is a beta lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-228" EXACT CARD_Short_Name [] [Term] id: ARO:3005260 name: TEM-229 namespace: antibiotic_resistance def: "TEM-229 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-229" EXACT CARD_Short_Name [] [Term] id: ARO:3005261 name: TEM-230 namespace: antibiotic_resistance def: "TEM-230 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-230" EXACT CARD_Short_Name [] [Term] id: ARO:3005262 name: TEM-231 namespace: antibiotic_resistance def: "TEM-231 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-231" EXACT CARD_Short_Name [] [Term] id: ARO:3005263 name: TEM-232 namespace: antibiotic_resistance def: "TEM-232 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-232" EXACT CARD_Short_Name [] [Term] id: ARO:3005264 name: TEM-233 namespace: antibiotic_resistance def: "TEM-233 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-233" EXACT CARD_Short_Name [] [Term] id: ARO:3005265 name: TEM-234 namespace: antibiotic_resistance def: "TEM-234 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-234" EXACT CARD_Short_Name [] [Term] id: ARO:3005266 name: TEM-235 namespace: antibiotic_resistance def: "TEM-235 is a beta-lactamase." [PMID:19713526] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-235" EXACT CARD_Short_Name [] [Term] id: ARO:3005267 name: TEM-236 namespace: antibiotic_resistance def: "TEM-236 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-236" EXACT CARD_Short_Name [] [Term] id: ARO:3005268 name: TEM-237 namespace: antibiotic_resistance def: "TEM-237 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-237" EXACT CARD_Short_Name [] [Term] id: ARO:3005269 name: TEM-238 namespace: antibiotic_resistance def: "TEM-238 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-238" EXACT CARD_Short_Name [] [Term] id: ARO:3005270 name: TEM-240 namespace: antibiotic_resistance def: "TEM-240 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-240" EXACT CARD_Short_Name [] [Term] id: ARO:3005271 name: TEM-241 namespace: antibiotic_resistance def: "TEM-241 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-241" EXACT CARD_Short_Name [] [Term] id: ARO:3005272 name: TEM-242 namespace: antibiotic_resistance def: "TEM-242 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-242" EXACT CARD_Short_Name [] [Term] id: ARO:3005273 name: TEM-243 namespace: antibiotic_resistance def: "TEM-243 is a beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-243" EXACT CARD_Short_Name [] [Term] id: ARO:3005274 name: PDC-225 namespace: antibiotic_resistance def: "PDC-225 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-225" EXACT CARD_Short_Name [] [Term] id: ARO:3005275 name: PDC-438 namespace: antibiotic_resistance def: "PDC-438 is class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-438" EXACT CARD_Short_Name [] [Term] id: ARO:3005276 name: PDC-284 namespace: antibiotic_resistance def: "PDC-284 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-284" EXACT CARD_Short_Name [] [Term] id: ARO:3005277 name: PDC-105 namespace: antibiotic_resistance def: "PDC-105 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-105" EXACT CARD_Short_Name [] [Term] id: ARO:3005278 name: PDC-118 namespace: antibiotic_resistance def: "PDC-118 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-118" EXACT CARD_Short_Name [] [Term] id: ARO:3005279 name: PDC-324 namespace: antibiotic_resistance def: "PDC-324 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-324" EXACT CARD_Short_Name [] [Term] id: ARO:3005280 name: PDC-323 namespace: antibiotic_resistance def: "PDC-323 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-323" EXACT CARD_Short_Name [] [Term] id: ARO:3005281 name: PDC-258 namespace: antibiotic_resistance def: "PDC-258 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-258" EXACT CARD_Short_Name [] [Term] id: ARO:3005282 name: PDC-413 namespace: antibiotic_resistance def: "PDC-413 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-413" EXACT CARD_Short_Name [] [Term] id: ARO:3005283 name: PDC-384 namespace: antibiotic_resistance def: "PDC-384 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-384" EXACT CARD_Short_Name [] [Term] id: ARO:3005284 name: PDC-264 namespace: antibiotic_resistance def: "PDC-264 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-264" EXACT CARD_Short_Name [] [Term] id: ARO:3005285 name: PDC-201 namespace: antibiotic_resistance def: "PDC-201 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-201" EXACT CARD_Short_Name [] [Term] id: ARO:3005286 name: PDC-346 namespace: antibiotic_resistance def: "PDC-346 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-346" EXACT CARD_Short_Name [] [Term] id: ARO:3005287 name: PDC-285 namespace: antibiotic_resistance def: "PDC-285 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-285" EXACT CARD_Short_Name [] [Term] id: ARO:3005288 name: PDC-337 namespace: antibiotic_resistance def: "PDC-337 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-337" EXACT CARD_Short_Name [] [Term] id: ARO:3005289 name: PDC-212 namespace: antibiotic_resistance def: "PDC-212 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-212" EXACT CARD_Short_Name [] [Term] id: ARO:3005290 name: PDC-352 namespace: antibiotic_resistance def: "PDC-352 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-352" EXACT CARD_Short_Name [] [Term] id: ARO:3005291 name: PDC-464 namespace: antibiotic_resistance def: "PDC-464 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-464" EXACT CARD_Short_Name [] [Term] id: ARO:3005292 name: PDC-19b namespace: antibiotic_resistance def: "PDC-19b is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-19b" EXACT CARD_Short_Name [] [Term] id: ARO:3005293 name: PDC-380 namespace: antibiotic_resistance def: "PDC-380 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-380" EXACT CARD_Short_Name [] [Term] id: ARO:3005294 name: PDC-461 namespace: antibiotic_resistance def: "PDC-461 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-461" EXACT CARD_Short_Name [] [Term] id: ARO:3005295 name: PDC-19a namespace: antibiotic_resistance def: "PDC-19a is a class C beta-lactamase found in Pseudomonas (multispecies)." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-19a" EXACT CARD_Short_Name [] [Term] id: ARO:3005296 name: PDC-272 namespace: antibiotic_resistance def: "PDC-272 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-272" EXACT CARD_Short_Name [] [Term] id: ARO:3005297 name: PDC-255 namespace: antibiotic_resistance def: "PDC-255 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-255" EXACT CARD_Short_Name [] [Term] id: ARO:3005298 name: PDC-293 namespace: antibiotic_resistance def: "PDC-293 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-293" EXACT CARD_Short_Name [] [Term] id: ARO:3005299 name: PDC-183 namespace: antibiotic_resistance def: "PDC-183 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-183" EXACT CARD_Short_Name [] [Term] id: ARO:3005300 name: PDC-207 namespace: antibiotic_resistance def: "PDC-207 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-207" EXACT CARD_Short_Name [] [Term] id: ARO:3005301 name: PDC-306 namespace: antibiotic_resistance def: "PDC-306 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-306" EXACT CARD_Short_Name [] [Term] id: ARO:3005302 name: PDC-376 namespace: antibiotic_resistance def: "PDC-376 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-376" EXACT CARD_Short_Name [] [Term] id: ARO:3005303 name: PDC-117 namespace: antibiotic_resistance def: "PDC-117 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-117" EXACT CARD_Short_Name [] [Term] id: ARO:3005304 name: PDC-231 namespace: antibiotic_resistance def: "PDC-231 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-231" EXACT CARD_Short_Name [] [Term] id: ARO:3005305 name: PDC-104 namespace: antibiotic_resistance def: "PDC-104 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-104" EXACT CARD_Short_Name [] [Term] id: ARO:3005306 name: PDC-173 namespace: antibiotic_resistance def: "PDC-173 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-173" EXACT CARD_Short_Name [] [Term] id: ARO:3005307 name: PDC-292 namespace: antibiotic_resistance def: "PDC-292 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-292" EXACT CARD_Short_Name [] [Term] id: ARO:3005308 name: PDC-393 namespace: antibiotic_resistance def: "PDC-393 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-393" EXACT CARD_Short_Name [] [Term] id: ARO:3005309 name: PDC-119 namespace: antibiotic_resistance def: "PDC-119 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-119" EXACT CARD_Short_Name [] [Term] id: ARO:3005310 name: PDC-313 namespace: antibiotic_resistance def: "PDC-313 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-313" EXACT CARD_Short_Name [] [Term] id: ARO:3005311 name: PDC-257 namespace: antibiotic_resistance def: "PDC-257 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-257" EXACT CARD_Short_Name [] [Term] id: ARO:3005312 name: PDC-429 namespace: antibiotic_resistance def: "PDC-429 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-429" EXACT CARD_Short_Name [] [Term] id: ARO:3005313 name: PDC-449 namespace: antibiotic_resistance def: "PDC-449 is a class C beta-lactamase found in Pseudomonas aeruginosa." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-449" EXACT CARD_Short_Name [] [Term] id: ARO:3005314 name: OXA-540 namespace: antibiotic_resistance def: "OXA-540 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-540" EXACT CARD_Short_Name [] [Term] id: ARO:3005315 name: OXA-779 namespace: antibiotic_resistance def: "OXA-779 is a beta-lactamase in the OXA-46 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007720 ! OXA-46-like beta-lactamase synonym: "OXA-779" EXACT CARD_Short_Name [] [Term] id: ARO:3005316 name: OXA-838 namespace: antibiotic_resistance def: "OXA-838 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-838" EXACT CARD_Short_Name [] [Term] id: ARO:3005317 name: OXA-539 namespace: antibiotic_resistance def: "OXA-539 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [PMID:28674059] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-539" EXACT CARD_Short_Name [] [Term] id: ARO:3005318 name: OXA-543 namespace: antibiotic_resistance def: "OXA-543 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-543" EXACT CARD_Short_Name [] [Term] id: ARO:3005319 name: OXA-681 namespace: antibiotic_resistance def: "OXA-681 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-681" EXACT CARD_Short_Name [] [Term] id: ARO:3005320 name: OXA-737 namespace: antibiotic_resistance def: "OXA-737 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-737" EXACT CARD_Short_Name [] [Term] id: ARO:3005321 name: OXA-541 namespace: antibiotic_resistance def: "OXA-541 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007704 ! OXA-2-like beta-lactamase synonym: "OXA-541" EXACT CARD_Short_Name [] [Term] id: ARO:3005322 name: OXA-835 namespace: antibiotic_resistance def: "OXA-835 is a beta-lactamase in the OXA-46 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007720 ! OXA-46-like beta-lactamase synonym: "OXA-835" EXACT CARD_Short_Name [] [Term] id: ARO:3005323 name: OXA-926 namespace: antibiotic_resistance def: "OXA-926 is a class D beta-lactamase in the family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-926" EXACT CARD_Short_Name [] [Term] id: ARO:3005324 name: OXA-570 namespace: antibiotic_resistance def: "OXA-570 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007729 ! OXA-60-like beta-lactamase synonym: "OXA-570" EXACT CARD_Short_Name [] [Term] id: ARO:3005325 name: OXA-573 namespace: antibiotic_resistance def: "OXA-573 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007729 ! OXA-60-like beta-lactamase synonym: "OXA-573" EXACT CARD_Short_Name [] [Term] id: ARO:3005326 name: OXA-571 namespace: antibiotic_resistance def: "OXA-571 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007729 ! OXA-60-like beta-lactamase synonym: "OXA-571" EXACT CARD_Short_Name [] [Term] id: ARO:3005327 name: OXA-672 namespace: antibiotic_resistance def: "OXA-672 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-672" EXACT CARD_Short_Name [] [Term] id: ARO:3005328 name: OXA-671 namespace: antibiotic_resistance def: "OXA-671 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-671" EXACT CARD_Short_Name [] [Term] id: ARO:3005329 name: OXA-673 namespace: antibiotic_resistance def: "OXA-673 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-673" EXACT CARD_Short_Name [] [Term] id: ARO:3005330 name: OXA-931 namespace: antibiotic_resistance def: "OXA-931 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-931" EXACT CARD_Short_Name [] [Term] id: ARO:3005331 name: OXA-930 namespace: antibiotic_resistance def: "OXA-930 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-930" EXACT CARD_Short_Name [] [Term] id: ARO:3005332 name: OXA-895 namespace: antibiotic_resistance def: "OXA-895 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007709 ! OXA-229-like beta-lactamase synonym: "OXA-895" EXACT CARD_Short_Name [] [Term] id: ARO:3005333 name: OXA-641 namespace: antibiotic_resistance def: "OXA-641 is a beta-lactamase in the OXA-372 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007717 ! OXA-372-like beta-lactamase synonym: "OXA-641" EXACT CARD_Short_Name [] [Term] id: ARO:3005334 name: Trimethoprim-resistant dihydrofolate reductase DfrA42 namespace: antibiotic_resistance def: "DfrA42 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication." [PMID:33593833] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "DfrA42" EXACT [] synonym: "DfrA42_TMP" EXACT CARD_Short_Name [] [Term] id: ARO:3005335 name: OXA-496 namespace: antibiotic_resistance def: "OXA-496 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [PMID:30150791] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-496" EXACT CARD_Short_Name [] [Term] id: ARO:3005336 name: OXA-915 namespace: antibiotic_resistance def: "OXA-915 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-915" EXACT CARD_Short_Name [] [Term] id: ARO:3005337 name: OXA-647 namespace: antibiotic_resistance def: "OXA-647 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-647" EXACT CARD_Short_Name [] [Term] id: ARO:3005338 name: OXA-648 namespace: antibiotic_resistance def: "OXA-648 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-648" EXACT CARD_Short_Name [] [Term] id: ARO:3005339 name: OXA-646 namespace: antibiotic_resistance def: "OXA-646 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-646" EXACT CARD_Short_Name [] [Term] id: ARO:3005340 name: OXA-649 namespace: antibiotic_resistance def: "OXA-649 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-649" EXACT CARD_Short_Name [] [Term] id: ARO:3005341 name: OXA-897 namespace: antibiotic_resistance def: "OXA-897 is a beta-lactamase in the OXA-24 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-897" EXACT CARD_Short_Name [] [Term] id: ARO:3005342 name: OXA-653 namespace: antibiotic_resistance def: "OXA-653 is a beta-lactamase in the OXA-24 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007711 ! OXA-24-like beta-lactamase synonym: "OXA-653" EXACT CARD_Short_Name [] [Term] id: ARO:3005343 name: OXA-499 namespace: antibiotic_resistance def: "OXA-499 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [PMID:28264850] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-499" EXACT CARD_Short_Name [] [Term] id: ARO:3005344 name: OXA-825 namespace: antibiotic_resistance def: "OXA-825 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin." [] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-825" EXACT CARD_Short_Name [] [Term] id: ARO:3005345 name: Trimethoprim-resistant dihydrofolate reductase DfrA43 namespace: antibiotic_resistance def: "DfrA43 is a dihydrofolate reductase that confers resistance to Trimethoprim. Originially described by Shi YZ et al, 2016, and isolated from Proteus penneri." [PMID:33593833] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "DfrA43" EXACT [] synonym: "DfrA43_TMP" EXACT CARD_Short_Name [] [Term] id: ARO:3005346 name: DfrA34 namespace: antibiotic_resistance def: "DfrA34 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication." [PMID:30202900] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "DfrA34" EXACT CARD_Short_Name [] synonym: "trimethoprim resistant dfra34" EXACT [] [Term] id: ARO:3005347 name: DfrA37 namespace: antibiotic_resistance def: "DfrA37 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication." [PMID:32318052] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "DfrA37" EXACT CARD_Short_Name [] synonym: "trimethoprim resistant dihydrofolate reductase dfra37" EXACT [] [Term] id: ARO:3005348 name: DfrA36 namespace: antibiotic_resistance def: "DfrA36 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally described by Wuthrich et al., 2019, and isolated from Escherichia coli." [PMID:31068437] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "DfrA36" EXACT CARD_Short_Name [] synonym: "trimethoprim-resistant dihydrofolate reductase DfrA36" EXACT [] [Term] id: ARO:3005349 name: DfrA38 namespace: antibiotic_resistance def: "DfrA38 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication." [PMID:32929451] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "DfrA38" EXACT CARD_Short_Name [] synonym: "trimethoprim-resistant dihydrofolate reductase DfrA38" EXACT [] [Term] id: ARO:3005350 name: DfrB9 namespace: antibiotic_resistance def: "DfrB9 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication." [PMID:33924456, PMID:33214838] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "DfrB9" EXACT CARD_Short_Name [] synonym: "trimethoprim-resistant dihydrofolate reductase DfrB9" EXACT [] [Term] id: ARO:3005351 name: DfrA39 namespace: antibiotic_resistance def: "DfrA39 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication." [PMID:34180526] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "DfrA39" EXACT CARD_Short_Name [] synonym: "trimethoprim-resistant dihydrofolate reductase DfrA39" EXACT [] [Term] id: ARO:3005354 name: dfr22 namespace: antibiotic_resistance def: "Dfr22 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally detected by Grape et al., (2005) and isolated from Escherichia coli." [PMID:15715715] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfr22" EXACT CARD_Short_Name [] synonym: "trimethoprim-resistance dihydrofolate reductase type 22" EXACT [] [Term] id: ARO:3005356 name: KPC-23 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-23 [Klebsiella pneumoniae] Accession: WP_111672911.1." [PMID:30928562] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-23" EXACT CARD_Short_Name [] [Term] id: ARO:3005357 name: KPC-25 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-25 [Klebsiella pneumoniae] Accession: WP_065419571.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-25" EXACT CARD_Short_Name [] [Term] id: ARO:3005358 name: KPC-26 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-26 [Klebsiella pneumoniae] Accession: WP_068981634.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-26" EXACT CARD_Short_Name [] [Term] id: ARO:3005359 name: KPC-27 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-27 [Klebsiella pneumoniae] Accession: WP_077064886.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-27" EXACT CARD_Short_Name [] [Term] id: ARO:3005360 name: KPC-29 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-29 [Klebsiella pneumoniae] Accession: WP_096807439.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-29" EXACT CARD_Short_Name [] [Term] id: ARO:3005361 name: KPC-28 namespace: antibiotic_resistance def: "Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-28 [Escherichia coli] Accession: WP_072081992.1." [PMID:31127297] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-28" EXACT CARD_Short_Name [] [Term] id: ARO:3005362 name: KPC-31 namespace: antibiotic_resistance def: "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-31 [Klebsiella] Accession: WP_073668892.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-31" EXACT CARD_Short_Name [] [Term] id: ARO:3005363 name: KPC-32 namespace: antibiotic_resistance def: "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-32 [Klebsiella pneumoniae] Accession: WP_073800284.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-32" EXACT CARD_Short_Name [] [Term] id: ARO:3005364 name: KPC-30 namespace: antibiotic_resistance def: "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-30 [Klebsiella pneumoniae] Accession: WP_085562399.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-30" EXACT CARD_Short_Name [] [Term] id: ARO:3005365 name: KPC-33 namespace: antibiotic_resistance def: "Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-33 [Klebsiella pneumoniae] Accession: WP_101140102.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-33" EXACT CARD_Short_Name [] [Term] id: ARO:3005366 name: KPC-34 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-34 [Klebsiella pneumoniae] Accession: WP_109545044.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-34" EXACT CARD_Short_Name [] [Term] id: ARO:3005367 name: KPC-35 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-35 [Klebsiella pneumoniae] Accession: WP_111273852.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-35" EXACT CARD_Short_Name [] [Term] id: ARO:3005368 name: KPC-36 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-36 [Klebsiella pneumoniae] Accession: WP_114699267.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-36" EXACT CARD_Short_Name [] [Term] id: ARO:3005369 name: KPC-37 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-37 [Klebsiella pneumoniae] Accession: WP_116786832.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-37" EXACT CARD_Short_Name [] [Term] id: ARO:3005370 name: KPC-38 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-38 [Klebsiella pneumoniae] Accession: WP_123002101.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-38" EXACT CARD_Short_Name [] [Term] id: ARO:3005371 name: KPC-39 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-39 [Klebsiella pneumoniae] Accession: WP_128268237.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-39" EXACT CARD_Short_Name [] [Term] id: ARO:3005372 name: KPC-40 namespace: antibiotic_resistance def: "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-40 [Enterobacter hormaechei] Accession: WP_115470049.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-40" EXACT CARD_Short_Name [] [Term] id: ARO:3005373 name: KPC-41 namespace: antibiotic_resistance def: "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-41 [Klebsiella pneumoniae] Accession: WP_148044419.1." [PMID:31527032] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-41" EXACT CARD_Short_Name [] [Term] id: ARO:3005374 name: KPC-42 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-42 [Klebsiella pneumoniae] Accession: WP_136512070.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-42" EXACT CARD_Short_Name [] [Term] id: ARO:3005375 name: KPC-43 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-43 [Klebsiella pneumoniae] Accession: WP_136512071.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-43" EXACT CARD_Short_Name [] [Term] id: ARO:3005376 name: KPC-45 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-45 [Enterobacter cloacae] Accession: WP_148044420.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-45" EXACT CARD_Short_Name [] [Term] id: ARO:3005377 name: KPC-46 namespace: antibiotic_resistance def: "Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-46 [Klebsiella pneumoniae] Accession: WP_148044421.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-46" EXACT CARD_Short_Name [] [Term] id: ARO:3005378 name: KPC-49 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-49 [Escherichia coli] Accession: WP_197749402.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-49" EXACT CARD_Short_Name [] [Term] id: ARO:3005379 name: KPC-50 namespace: antibiotic_resistance def: "Inhibitor-resistant class A beta-lactamase kpc-50 [Klebsiella pneumoniae] Accession: WP_171476788.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-50" EXACT CARD_Short_Name [] [Term] id: ARO:3005380 name: KPC-51 namespace: antibiotic_resistance def: "Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-51 [Klebsiella pneumoniae] Accession: WP_158208923.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-51" EXACT CARD_Short_Name [] [Term] id: ARO:3005381 name: KPC-52 namespace: antibiotic_resistance def: "Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-52 [Klebsiella pneumoniae] Accession: WP_158208806.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-52" EXACT CARD_Short_Name [] [Term] id: ARO:3005382 name: KPC-54 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-54 [Klebsiella pneumoniae] Accession: WP_160164839.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-54" EXACT CARD_Short_Name [] [Term] id: ARO:3005383 name: KPC-55 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-55 [Klebsiella pneumoniae] Accession: WP_168247883.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-55" EXACT CARD_Short_Name [] [Term] id: ARO:3005384 name: KPC-56 namespace: antibiotic_resistance def: "Carbapenem-hydrolyzing class A beta-lactamase kpc-56 [Klebsiella pneumoniae] Accession: WP_087744800.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-56" EXACT CARD_Short_Name [] [Term] id: ARO:3005385 name: KPC-57 namespace: antibiotic_resistance def: "Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-57 [Klebsiella pneumoniae] Accession: WP_171476789.1." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-57" EXACT CARD_Short_Name [] [Term] id: ARO:3005386 name: disinfecting agents and antiseptics namespace: antibiotic_resistance def: "Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3005387 name: AAK beta-lactamase namespace: antibiotic_resistance def: "AAK beta-lactamases are a group of class A beta-lactamases found in Klebsiella pneumoniae." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005388 name: AFM beta-lactamase namespace: antibiotic_resistance def: "AFM beta-lactamases are class B1 beta-lactamases found in proteobacteria like Pseudomonas aeruginosa." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005389 name: ALG11 beta-lactamase namespace: antibiotic_resistance def: "ALG11 beta-lactamases are class B3 beta-lactamases." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005390 name: ALG6 beta-lactamases namespace: antibiotic_resistance def: "ALG6 beta-lactamases are class B3 beta-lactamases." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005391 name: ALI beta-lactamase namespace: antibiotic_resistance def: "ALI beta-lactamases are class B1 beta-lactamases found in species of the Aliivibrio genus." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005392 name: ANA beta-lactamase namespace: antibiotic_resistance def: "ANA beta-lactamases are class B1 beta-lactamases found in Anaeromyxobacter." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005393 name: AXC beta-lactamase namespace: antibiotic_resistance def: "AXC beta-lactamases are class A beta-lactamase found in the Anaeromyxobacter genus." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005394 name: BSU beta-lactamase namespace: antibiotic_resistance def: "BSU beta-lactamases are class D beta-lactamases found in Bacillus inaquosorum." [] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005395 name: CAR beta-lactamase namespace: antibiotic_resistance def: "CAR beta-lactamases are class B3 beta-lactamases found in Pectobacterium atrosepticum." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005396 name: CDD beta-lactamase namespace: antibiotic_resistance def: "CDD beta-lactamases are class D beta-lactamases found in Clostridioides difficile." [] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005397 name: CMA beta-lactamase namespace: antibiotic_resistance def: "CMA beta-lactamases are class C beta-lactamases found in Cronobacter malonaticus." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005398 name: CRD3 beta-lactamase namespace: antibiotic_resistance def: "CRD3 beta-lactamases are class B3 beta-lactamases." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005399 name: CRH beta-lactamase namespace: antibiotic_resistance def: "CRH beta-lactamases are class A beta-lactamases found in Chromobacterium haemolyticum." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005400 name: CRP beta-lactamase namespace: antibiotic_resistance def: "CRP beta-lactamases are class A beta-lactamase found in Chromobacterium piscinae." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005401 name: CSA beta-lactamase namespace: antibiotic_resistance def: "CSA beta-lactamases are class C beta-lactamases found in Cronobacter sakazakii." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005402 name: CSP beta-lactamase namespace: antibiotic_resistance def: "CSP beta-lactamases are class A beta-lactamases found in Capnocytophaga sputigena." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005403 name: CVI beta-lactamase namespace: antibiotic_resistance def: "CVI beta-lactamases are a class B2 beta-lactamase found in Chromobacterium violaceum." [] is_a: ARO:3000570 ! subclass B2 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005404 name: DHT2 beta-lactamase namespace: antibiotic_resistance def: "DHT2 beta-lactamases are class B3 beta-lactamases." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005405 name: EAM beta-lactamase namespace: antibiotic_resistance def: "EAM beta-lactamase are class B3 beta-lactamases found in Qipengyuania aquimaris." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005406 name: EC beta-lactamase namespace: antibiotic_resistance def: "EC beta-lactamases are class C beta-lactamases found in Escherichia coli." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005407 name: ECM beta-lactamase namespace: antibiotic_resistance def: "ECM beta-lactamases are class B3 beta-lactamases found in Qipengyuania citrea." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005408 name: ECV beta-lactamase namespace: antibiotic_resistance def: "ECV beta-lactamases are class B1 beta-lactamases found in Echinicola vietnamensis." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005409 name: EFM beta-lactamase namespace: antibiotic_resistance def: "EFM beta-lactamases are class B3 beta-lactamase found in Qipengyuania flava." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005410 name: ELM beta-lactamase namespace: antibiotic_resistance def: "ELM beta-lactamases are class B3 beta-lactamases found in Erythrobacter longus." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005411 name: EVM beta-lactamase namespace: antibiotic_resistance def: "EVM beta-lactamases are class B3 beta-lactamases found in Qipengyuania vulgaris." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005412 name: FIA beta-lactamase namespace: antibiotic_resistance def: "FIA beta-lactamases are class B1 beta-lactamases found in Fibrella aestuarina." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005413 name: GIL beta-lactamase namespace: antibiotic_resistance def: "GIL-beta-lactamases are class A beta-lactamases found in Citrobacter gillenii." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005414 name: GMB beta-lactamase namespace: antibiotic_resistance def: "GMB beta-lactamases are class B1 beta-lactamases found in Citrobacter freundii." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005415 name: GRD23 beta-lactamase namespace: antibiotic_resistance def: "GRD23 beta-lactamases are class B1 beta-lactamases." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005416 name: GRD33 beta-lactamase namespace: antibiotic_resistance def: "GRD33 beta-lactamases are class B3 beta-lactamase." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005417 name: KLUC beta-lactamase namespace: antibiotic_resistance def: "KLUC beta-lactamases are class A beta-lactamases found in Kluyvera cryocrescens, Escherichia coli and Enterobacteriaceae." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005418 name: LHK beta-lactamase namespace: antibiotic_resistance def: "LHK beta-lactamases are class C beta-lactamases found in Laribacter hongkongensis." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005419 name: LRG beta-lactamase namespace: antibiotic_resistance def: "LRG beta-lactamases are class A beta-lactamases." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005420 name: LUS beta-lactamase namespace: antibiotic_resistance def: "LUS beta-lactamases are class A beta-lactamases found in Pedobacter lusitanus." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005421 name: LUT beta-lactamase namespace: antibiotic_resistance def: "LUT beta-lactamases are class A beta lactamases found in Pseudomonas luteola." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005422 name: MAL beta-lactamase namespace: antibiotic_resistance def: "MAL beta-lactamase are class A beta-lactamases found in Citrobacter koseri." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005423 name: MBL beta-lactamase namespace: antibiotic_resistance def: "MBL beta-lactamases are class B3 beta-lactamases found in Caulobacter vibrioides." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005424 name: MOC beta-lactamase namespace: antibiotic_resistance def: "MOC beta-lactamases are class B1 beta-lactamase found in Myroides odoratus." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005425 name: MOR beta-lactamase namespace: antibiotic_resistance def: "MOR beta-lactamases are class C beta-lactamases found in Morganella morganii." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005426 name: MYO beta-lactamase namespace: antibiotic_resistance def: "MYO beta-lactamases are class B1 beta-lactamases found in Myroides odoratimimus." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005427 name: MYX beta-lactamase namespace: antibiotic_resistance def: "MYX beta-lactamases are class B1 beta-lactamases found in Myxococcus." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005428 name: OHIO beta-lactamase namespace: antibiotic_resistance def: "OHIO beta-lactamases are class A beta-lactamases." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005429 name: ORN beta-lactamase namespace: antibiotic_resistance def: "ORN beta-lactamases are class A beta-lactamases found in Raoultella ornithinolytica." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005430 name: ORR beta-lactamase namespace: antibiotic_resistance def: "ORR beta-lactamases are class B1 beta-lactamases found in Ornithobacterium rhinotracheale." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005431 name: PAU beta-lactamase namespace: antibiotic_resistance def: "PAU beta-lactamases are class A beta-lactamases found in Pseudomonas aeruginosa." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005432 name: PFM beta-lactamase namespace: antibiotic_resistance def: "PFM beta-lactamases are class B2 beta-lactamases found in Pseudomonas fluorescens." [] is_a: ARO:3000570 ! subclass B2 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005433 name: PLA beta-lactamase namespace: antibiotic_resistance def: "PLA beta-lactamases are class A beta-lactamase found in Raoultella planticola." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005434 name: PLN beta-lactamase namespace: antibiotic_resistance def: "PLN beta-lactamases are class B3 beta-lactamases found in Pedobacter lusitanus." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005435 name: PME beta-lactamase namespace: antibiotic_resistance def: "PME beta-lactamases are class A beta-lactamases found in Gammaproteobacteria." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005436 name: POM beta-lactamase namespace: antibiotic_resistance def: "POM beta-lactamases are class B3 beta-lactamases found in Pseudomonas otitidis." [] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005437 name: PST beta-lactamase namespace: antibiotic_resistance def: "PST bea-lactamases are class B1 beta-lactamases found in Pseudomonas stutzeri." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005438 name: PSV beta-lactamase namespace: antibiotic_resistance def: "PSV beta-lactamases are class A beta-lactamases found in Pseudovibrio." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005439 name: RAHN beta-lactamase namespace: antibiotic_resistance def: "RAHN beta-lactamases are class A beta-lactamases found in Rahnella aquatilis." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005440 name: RSA2 beta-lactamase namespace: antibiotic_resistance def: "RSA2 beta-lactamases are class A beta-lactamases." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005441 name: RSD2 beta-lactamase namespace: antibiotic_resistance def: "RSD2 beta-lactamases are class D beta-lactamases." [] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005442 name: RUB beta-lactamase namespace: antibiotic_resistance def: "RUB beta-lactamases are class A beta-lactamases found in Serratia rubidaea." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005443 name: SFC beta-lactamase namespace: antibiotic_resistance def: "SFC beta-lactamases are class A beta-lactamases found in Serratia fonticola." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005444 name: SFO beta-lactamase namespace: antibiotic_resistance def: "SFO beta-lactamases are class A beta-lactamases found in Gammaproteobacteria." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005445 name: SGM beta-lactamase namespace: antibiotic_resistance def: "SGM beta-lactamases are class A beta-lactamases found in members of the Sphingobium genus." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005446 name: SHN beta-lactamase namespace: antibiotic_resistance def: "SHN beta-lactamases are class B1 beta-lactamases found in Shewanella denitrificans." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005447 name: SPN79 beta-lactamase namespace: antibiotic_resistance def: "SPN beta-lactamases are class B1 beta-lactamases." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005448 name: SPR beta-lactamase namespace: antibiotic_resistance def: "SPR beta-lactamases are class B beta-lactamases found in Serratia proteamaculans." [] is_a: ARO:3000004 ! class B (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005449 name: SPS beta-lactamase namespace: antibiotic_resistance def: "SPS beta-lactamases are class B1 beta lactamases found in Sediminispirochaeta smaragdinae." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005450 name: SPU beta-lactamase namespace: antibiotic_resistance def: "SPU beta-lactamases are class A beta-lactamases found in Capnocytophaga sputigena." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005451 name: SST beta-lactamase namespace: antibiotic_resistance def: "SST beta-lactamases are class C beta-lactamases found in Serratia marcescens." [] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005452 name: STA beta-lactamase namespace: antibiotic_resistance def: "STA beta-lactamases are class B1 beta-lactamases found in Stigmatella aurantiaca." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005453 name: TER beta-lactamase namespace: antibiotic_resistance def: "TER beta-lactamases are class A beta-lactamases found in Raoultella terrigena." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005454 name: TTU beta-lactamase namespace: antibiotic_resistance def: "TTU beta-lactamases are class B1 beta-lactamases found in Teredinibacter turnerae." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005455 name: VHH beta-lactamase namespace: antibiotic_resistance def: "VHH beta-lactamases are class A beta-lactamases found in Vibrio harveyi." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005456 name: VHW beta-lactamase namespace: antibiotic_resistance def: "VHW beta-lactamases are class A beta-lactamases found Vibrio harveyi." [] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005457 name: YEM beta-lactamase namespace: antibiotic_resistance def: "YEM beta-lactamases are class B2 beta-lactamases found in Yersinia mollaretii." [] is_a: ARO:3000570 ! subclass B2 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005458 name: ZOG beta-lactamase namespace: antibiotic_resistance def: "ZOG beta-lactamases are class B1 beta-lactamases found in Zobellia galactanivorans." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3005459 name: ADC beta-lactamase namespace: antibiotic_resistance def: "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins and may or may not cause resistance to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis." [] is_a: ARO:3000076 ! class C beta-lactamase [Term] id: ARO:3005460 name: ADC beta-lactamases pending classification for carbapenemase activity namespace: antibiotic_resistance def: "ADC beta-lactamases with undetermined carbapenemase activity." [] is_a: ARO:3005459 ! ADC beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3005461 name: EBR-3 namespace: antibiotic_resistance def: "EBR-3 is a EBR beta-lactamase." [] is_a: ARO:3004204 ! EBR beta-lactamase synonym: "EBR-3" EXACT CARD_Short_Name [] [Term] id: ARO:3005462 name: EBR-4 namespace: antibiotic_resistance def: "EBR-4 is a EBR beta-lactamase." [] is_a: ARO:3004204 ! EBR beta-lactamase synonym: "EBR-4" EXACT CARD_Short_Name [] [Term] id: ARO:3005463 name: IMP-53 namespace: antibiotic_resistance def: "IMP-53 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-53" EXACT CARD_Short_Name [] [Term] id: ARO:3005464 name: IMP-54 namespace: antibiotic_resistance def: "IMP-54 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-54" EXACT CARD_Short_Name [] [Term] id: ARO:3005465 name: IMP-58 namespace: antibiotic_resistance def: "IMP-58 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-58" EXACT CARD_Short_Name [] [Term] id: ARO:3005466 name: IMP-59 namespace: antibiotic_resistance def: "IMP-59 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-59" EXACT CARD_Short_Name [] [Term] id: ARO:3005467 name: IMP-60 namespace: antibiotic_resistance def: "IMP-60 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-60" EXACT CARD_Short_Name [] [Term] id: ARO:3005468 name: IMP-61 namespace: antibiotic_resistance def: "IMP-61 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-61" EXACT CARD_Short_Name [] [Term] id: ARO:3005469 name: IMP-62 namespace: antibiotic_resistance def: "IMP-62 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-62" EXACT CARD_Short_Name [] [Term] id: ARO:3005470 name: IMP-63 namespace: antibiotic_resistance def: "IMP-63 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-63" EXACT CARD_Short_Name [] [Term] id: ARO:3005471 name: IMP-64 namespace: antibiotic_resistance def: "IMP-64 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-64" EXACT CARD_Short_Name [] [Term] id: ARO:3005472 name: IMP-65 namespace: antibiotic_resistance def: "IMP-65 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-65" EXACT CARD_Short_Name [] [Term] id: ARO:3005473 name: IMP-66 namespace: antibiotic_resistance def: "IMP-66 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-66" EXACT CARD_Short_Name [] [Term] id: ARO:3005474 name: IMP-67 namespace: antibiotic_resistance def: "IMP-67 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-67" EXACT CARD_Short_Name [] [Term] id: ARO:3005475 name: IMP-69 namespace: antibiotic_resistance def: "IMP-69 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-69" EXACT CARD_Short_Name [] [Term] id: ARO:3005476 name: IMP-70 namespace: antibiotic_resistance def: "IMP-70 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-70" EXACT CARD_Short_Name [] [Term] id: ARO:3005477 name: IMP-71 namespace: antibiotic_resistance def: "IMP-71 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-71" EXACT CARD_Short_Name [] [Term] id: ARO:3005478 name: IMP-73 namespace: antibiotic_resistance def: "IMP-73 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-73" EXACT CARD_Short_Name [] [Term] id: ARO:3005479 name: IMP-74 namespace: antibiotic_resistance def: "IMP-74 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-74" EXACT CARD_Short_Name [] [Term] id: ARO:3005480 name: IMP-75 namespace: antibiotic_resistance def: "IMP-75 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-75" EXACT CARD_Short_Name [] [Term] id: ARO:3005481 name: IMP-76 namespace: antibiotic_resistance def: "IMP-76 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-76" EXACT CARD_Short_Name [] [Term] id: ARO:3005482 name: IMP-77 namespace: antibiotic_resistance def: "IMP-77 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-77" EXACT CARD_Short_Name [] [Term] id: ARO:3005483 name: IMP-78 namespace: antibiotic_resistance def: "IMP-78 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-78" EXACT CARD_Short_Name [] [Term] id: ARO:3005484 name: IMP-79 namespace: antibiotic_resistance def: "IMP-79 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-79" EXACT CARD_Short_Name [] [Term] id: ARO:3005485 name: IMP-80 namespace: antibiotic_resistance def: "IMP-80 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-80" EXACT CARD_Short_Name [] [Term] id: ARO:3005486 name: IMP-81 namespace: antibiotic_resistance def: "IMP-81 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-81" EXACT CARD_Short_Name [] [Term] id: ARO:3005487 name: IMP-82 namespace: antibiotic_resistance def: "IMP-82 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-82" EXACT CARD_Short_Name [] [Term] id: ARO:3005488 name: IMP-83 namespace: antibiotic_resistance def: "IMP-83 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-83" EXACT CARD_Short_Name [] [Term] id: ARO:3005489 name: IMP-84 namespace: antibiotic_resistance def: "IMP-84 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-84" EXACT CARD_Short_Name [] [Term] id: ARO:3005490 name: IMP-85 namespace: antibiotic_resistance def: "IMP-85 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-85" EXACT CARD_Short_Name [] [Term] id: ARO:3005491 name: IMP-88 namespace: antibiotic_resistance def: "IMP-88 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-88" EXACT CARD_Short_Name [] [Term] id: ARO:3005492 name: IMP-89 namespace: antibiotic_resistance def: "IMP-89 is a IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-89" EXACT CARD_Short_Name [] [Term] id: ARO:3005493 name: IND-16 namespace: antibiotic_resistance def: "IND-16 is a IND beta-lactamase." [] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-16" EXACT CARD_Short_Name [] [Term] id: ARO:3005494 name: SIM-2 namespace: antibiotic_resistance def: "SIM-2 is a SIM beta-lactamase." [] is_a: ARO:3004206 ! SIM beta-lactamase synonym: "SIM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3005495 name: VIM-47 namespace: antibiotic_resistance def: "VIM-47 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-47" EXACT CARD_Short_Name [] [Term] id: ARO:3005496 name: VIM-48 namespace: antibiotic_resistance def: "VIM-48 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-48" EXACT CARD_Short_Name [] [Term] id: ARO:3005497 name: VIM-49 namespace: antibiotic_resistance def: "VIM-49 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-49" EXACT CARD_Short_Name [] [Term] id: ARO:3005498 name: VIM-50 namespace: antibiotic_resistance def: "VIM-50 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-50" EXACT CARD_Short_Name [] [Term] id: ARO:3005499 name: VIM-51 namespace: antibiotic_resistance def: "VIM-51 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-51" EXACT CARD_Short_Name [] [Term] id: ARO:3005500 name: VIM-52 namespace: antibiotic_resistance def: "VIM-52 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-52" EXACT CARD_Short_Name [] [Term] id: ARO:3005501 name: VIM-53 namespace: antibiotic_resistance def: "VIM-53 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-53" EXACT CARD_Short_Name [] [Term] id: ARO:3005502 name: VIM-54 namespace: antibiotic_resistance def: "VIM-54 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-54" EXACT CARD_Short_Name [] [Term] id: ARO:3005503 name: VIM-55 namespace: antibiotic_resistance def: "VIM-55 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-55" EXACT CARD_Short_Name [] [Term] id: ARO:3005504 name: VIM-56 namespace: antibiotic_resistance def: "VIM-56 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-56" EXACT CARD_Short_Name [] [Term] id: ARO:3005505 name: VIM-57 namespace: antibiotic_resistance def: "VIM-57 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-57" EXACT CARD_Short_Name [] [Term] id: ARO:3005506 name: VIM-58 namespace: antibiotic_resistance def: "VIM-58 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-58" EXACT CARD_Short_Name [] [Term] id: ARO:3005507 name: VIM-59 namespace: antibiotic_resistance def: "VIM-59 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-59" EXACT CARD_Short_Name [] [Term] id: ARO:3005508 name: VIM-60 namespace: antibiotic_resistance def: "VIM-60 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-60" EXACT CARD_Short_Name [] [Term] id: ARO:3005509 name: VIM-61 namespace: antibiotic_resistance def: "VIM-61 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-61" EXACT CARD_Short_Name [] [Term] id: ARO:3005510 name: VIM-62 namespace: antibiotic_resistance def: "VIM-62 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-62" EXACT CARD_Short_Name [] [Term] id: ARO:3005511 name: VIM-63 namespace: antibiotic_resistance def: "VIM-63 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3003707 ! faropenem synonym: "VIM-63" EXACT CARD_Short_Name [] [Term] id: ARO:3005512 name: VIM-64 namespace: antibiotic_resistance def: "VIM-64 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-64" EXACT CARD_Short_Name [] [Term] id: ARO:3005513 name: VIM-65 namespace: antibiotic_resistance def: "VIM-65 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-65" EXACT CARD_Short_Name [] [Term] id: ARO:3005514 name: VIM-66 namespace: antibiotic_resistance def: "VIM-66 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-66" EXACT CARD_Short_Name [] [Term] id: ARO:3005515 name: VIM-67 namespace: antibiotic_resistance def: "VIM-67 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-67" EXACT CARD_Short_Name [] [Term] id: ARO:3005516 name: VIM-68 namespace: antibiotic_resistance def: "VIM-68 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-68" EXACT CARD_Short_Name [] [Term] id: ARO:3005517 name: VIM-69 namespace: antibiotic_resistance def: "VIM-69 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-69" EXACT CARD_Short_Name [] [Term] id: ARO:3005518 name: VIM-70 namespace: antibiotic_resistance def: "VIM-70 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-70" EXACT CARD_Short_Name [] [Term] id: ARO:3005519 name: VIM-71 namespace: antibiotic_resistance def: "VIM-71 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-71" EXACT CARD_Short_Name [] [Term] id: ARO:3005520 name: VIM-72 namespace: antibiotic_resistance def: "VIM-72 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-72" EXACT CARD_Short_Name [] [Term] id: ARO:3005521 name: VIM-73 namespace: antibiotic_resistance def: "VIM-73 is a VIM beta-lactamase." [] is_a: ARO:3000021 ! VIM beta-lactamase synonym: "VIM-73" EXACT CARD_Short_Name [] [Term] id: ARO:3005522 name: BlaB-1 namespace: antibiotic_resistance def: "BlaB-1 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3005523 name: BlaB-10 namespace: antibiotic_resistance def: "BlaB-10 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-10" EXACT CARD_Short_Name [] [Term] id: ARO:3005524 name: BlaB-11 namespace: antibiotic_resistance def: "BlaB-11 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-11" EXACT CARD_Short_Name [] [Term] id: ARO:3005525 name: BlaB-12 namespace: antibiotic_resistance def: "BlaB-12 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-12" EXACT CARD_Short_Name [] [Term] id: ARO:3005526 name: BlaB-13 namespace: antibiotic_resistance def: "BlaB-13 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-13" EXACT CARD_Short_Name [] [Term] id: ARO:3005527 name: BlaB-14 namespace: antibiotic_resistance def: "BlaB-14 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-14" EXACT CARD_Short_Name [] [Term] id: ARO:3005528 name: BlaB-15 namespace: antibiotic_resistance def: "BlaB-15 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-15" EXACT CARD_Short_Name [] [Term] id: ARO:3005529 name: BlaB-16 namespace: antibiotic_resistance def: "BlaB-16 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-16" EXACT CARD_Short_Name [] [Term] id: ARO:3005530 name: BlaB-17 namespace: antibiotic_resistance def: "BlaB-17 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-17" EXACT CARD_Short_Name [] [Term] id: ARO:3005531 name: BlaB-18 namespace: antibiotic_resistance def: "BlaB-18 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-18" EXACT CARD_Short_Name [] [Term] id: ARO:3005532 name: BlaB-19 namespace: antibiotic_resistance def: "BlaB-19 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-19" EXACT CARD_Short_Name [] [Term] id: ARO:3005533 name: BlaB-2 namespace: antibiotic_resistance def: "BlaB-2 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-2" EXACT CARD_Short_Name [] [Term] id: ARO:3005534 name: BlaB-20 namespace: antibiotic_resistance def: "BlaB-20 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-20" EXACT CARD_Short_Name [] [Term] id: ARO:3005535 name: BlaB-22 namespace: antibiotic_resistance def: "BlaB-22 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-22" EXACT CARD_Short_Name [] [Term] id: ARO:3005536 name: BlaB-23 namespace: antibiotic_resistance def: "BlaB-23 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-23" EXACT CARD_Short_Name [] [Term] id: ARO:3005537 name: BlaB-24 namespace: antibiotic_resistance def: "BlaB-24 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-24" EXACT CARD_Short_Name [] [Term] id: ARO:3005538 name: BlaB-25 namespace: antibiotic_resistance def: "BlaB-25 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-25" EXACT CARD_Short_Name [] [Term] id: ARO:3005539 name: BlaB-26 namespace: antibiotic_resistance def: "BlaB-26 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-26" EXACT CARD_Short_Name [] [Term] id: ARO:3005540 name: BlaB-27 namespace: antibiotic_resistance def: "BlaB-27 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-27" EXACT CARD_Short_Name [] [Term] id: ARO:3005541 name: BlaB-28 namespace: antibiotic_resistance def: "BlaB-28 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-28" EXACT CARD_Short_Name [] [Term] id: ARO:3005542 name: BlaB-29 namespace: antibiotic_resistance def: "BlaB-29 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-29" EXACT CARD_Short_Name [] [Term] id: ARO:3005543 name: BlaB-3 namespace: antibiotic_resistance def: "BlaB-3 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-3" EXACT CARD_Short_Name [] [Term] id: ARO:3005544 name: BlaB-30 namespace: antibiotic_resistance def: "BlaB-30 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-30" EXACT CARD_Short_Name [] [Term] id: ARO:3005545 name: BlaB-31 namespace: antibiotic_resistance def: "BlaB-31 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-31" EXACT CARD_Short_Name [] [Term] id: ARO:3005546 name: BlaB-32 namespace: antibiotic_resistance def: "BlaB-32 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-32" EXACT CARD_Short_Name [] [Term] id: ARO:3005547 name: BlaB-33 namespace: antibiotic_resistance def: "BlaB-33 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-33" EXACT CARD_Short_Name [] [Term] id: ARO:3005548 name: BlaB-34 namespace: antibiotic_resistance def: "BlaB-34 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-34" EXACT CARD_Short_Name [] [Term] id: ARO:3005549 name: BlaB-35 namespace: antibiotic_resistance def: "BlaB-35 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-35" EXACT CARD_Short_Name [] [Term] id: ARO:3005550 name: BlaB-36 namespace: antibiotic_resistance def: "BlaB-36 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-36" EXACT CARD_Short_Name [] [Term] id: ARO:3005551 name: BlaB-38 namespace: antibiotic_resistance def: "BlaB-38 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-38" EXACT CARD_Short_Name [] [Term] id: ARO:3005552 name: BlaB-39 namespace: antibiotic_resistance def: "BlaB-39 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-39" EXACT CARD_Short_Name [] [Term] id: ARO:3005553 name: BlaB-5 namespace: antibiotic_resistance def: "BlaB-5 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-5" EXACT CARD_Short_Name [] [Term] id: ARO:3005554 name: BlaB-6 namespace: antibiotic_resistance def: "BlaB-6 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-6" EXACT CARD_Short_Name [] [Term] id: ARO:3005555 name: BlaB-7 namespace: antibiotic_resistance def: "BlaB-7 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-7" EXACT CARD_Short_Name [] [Term] id: ARO:3005556 name: BlaB-8 namespace: antibiotic_resistance def: "BlaB-8 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-8" EXACT CARD_Short_Name [] [Term] id: ARO:3005557 name: BlaB-9 namespace: antibiotic_resistance def: "BlaB-9 is a BlaB beta-lactamase." [] is_a: ARO:3004201 ! BlaB beta-lactamase synonym: "BlaB-9" EXACT CARD_Short_Name [] [Term] id: ARO:3005558 name: BUT-2 namespace: antibiotic_resistance def: "BUT-2 is a BUT beta-lactamase." [] is_a: ARO:3004293 ! BUT beta-lactamase synonym: "BUT-2" EXACT CARD_Short_Name [] [Term] id: ARO:3005559 name: CARB-11 namespace: antibiotic_resistance def: "CARB-11 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-11" EXACT CARD_Short_Name [] [Term] id: ARO:3005560 name: CARB-24 namespace: antibiotic_resistance def: "CARB-24 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-24" EXACT CARD_Short_Name [] [Term] id: ARO:3005561 name: CARB-25 namespace: antibiotic_resistance def: "CARB-25 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-25" EXACT CARD_Short_Name [] [Term] id: ARO:3005562 name: CARB-26 namespace: antibiotic_resistance def: "CARB-26 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-26" EXACT CARD_Short_Name [] [Term] id: ARO:3005563 name: CARB-27 namespace: antibiotic_resistance def: "CARB-27 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-27" EXACT CARD_Short_Name [] [Term] id: ARO:3005564 name: CARB-28 namespace: antibiotic_resistance def: "CARB-28 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-28" EXACT CARD_Short_Name [] [Term] id: ARO:3005565 name: CARB-29 namespace: antibiotic_resistance def: "CARB-29 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-29" EXACT CARD_Short_Name [] [Term] id: ARO:3005566 name: CARB-30 namespace: antibiotic_resistance def: "CARB-30 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-30" EXACT CARD_Short_Name [] [Term] id: ARO:3005567 name: CARB-31 namespace: antibiotic_resistance def: "CARB-31 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-31" EXACT CARD_Short_Name [] [Term] id: ARO:3005568 name: CARB-32 namespace: antibiotic_resistance def: "CARB-32 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-32" EXACT CARD_Short_Name [] [Term] id: ARO:3005569 name: CARB-33 namespace: antibiotic_resistance def: "CARB-33 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-33" EXACT CARD_Short_Name [] [Term] id: ARO:3005570 name: CARB-34 namespace: antibiotic_resistance def: "CARB-34 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-34" EXACT CARD_Short_Name [] [Term] id: ARO:3005571 name: CARB-35 namespace: antibiotic_resistance def: "CARB-35 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-35" EXACT CARD_Short_Name [] [Term] id: ARO:3005572 name: CARB-36 namespace: antibiotic_resistance def: "CARB-36 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-36" EXACT CARD_Short_Name [] [Term] id: ARO:3005573 name: CARB-38 namespace: antibiotic_resistance def: "CARB-38 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-38" EXACT CARD_Short_Name [] [Term] id: ARO:3005574 name: CARB-40 namespace: antibiotic_resistance def: "CARB-40 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-40" EXACT CARD_Short_Name [] [Term] id: ARO:3005575 name: CARB-41 namespace: antibiotic_resistance def: "CARB-41 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-41" EXACT CARD_Short_Name [] [Term] id: ARO:3005576 name: CARB-42 namespace: antibiotic_resistance def: "CARB-42 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-42" EXACT CARD_Short_Name [] [Term] id: ARO:3005577 name: CARB-43 namespace: antibiotic_resistance def: "CARB-43 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-43" EXACT CARD_Short_Name [] [Term] id: ARO:3005578 name: CARB-44 namespace: antibiotic_resistance def: "CARB-44 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-44" EXACT CARD_Short_Name [] [Term] id: ARO:3005579 name: CARB-45 namespace: antibiotic_resistance def: "CARB-45 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-45" EXACT CARD_Short_Name [] [Term] id: ARO:3005580 name: CARB-46 namespace: antibiotic_resistance def: "CARB-46 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-46" EXACT CARD_Short_Name [] [Term] id: ARO:3005581 name: CARB-47 namespace: antibiotic_resistance def: "CARB-47 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-47" EXACT CARD_Short_Name [] [Term] id: ARO:3005582 name: CARB-48 namespace: antibiotic_resistance def: "CARB-48 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-48" EXACT CARD_Short_Name [] [Term] id: ARO:3005583 name: CARB-49 namespace: antibiotic_resistance def: "CARB-49 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-49" EXACT CARD_Short_Name [] [Term] id: ARO:3005584 name: CARB-50 namespace: antibiotic_resistance def: "CARB-50 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-50" EXACT CARD_Short_Name [] [Term] id: ARO:3005585 name: CARB-51 namespace: antibiotic_resistance def: "CARB-51 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-51" EXACT CARD_Short_Name [] [Term] id: ARO:3005586 name: CARB-52 namespace: antibiotic_resistance def: "CARB-52 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-52" EXACT CARD_Short_Name [] [Term] id: ARO:3005587 name: CARB-53 namespace: antibiotic_resistance def: "CARB-53 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-53" EXACT CARD_Short_Name [] [Term] id: ARO:3005588 name: CARB-54 namespace: antibiotic_resistance def: "CARB-54 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-54" EXACT CARD_Short_Name [] [Term] id: ARO:3005589 name: CARB-55 namespace: antibiotic_resistance def: "CARB-55 is a CARB beta-lactamase." [] is_a: ARO:3000091 ! CARB beta-lactamase synonym: "CARB-55" EXACT CARD_Short_Name [] [Term] id: ARO:3005590 name: CTX-M-167 namespace: antibiotic_resistance def: "CTX-M-167 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-167" EXACT CARD_Short_Name [] [Term] id: ARO:3005591 name: CTX-M-168 namespace: antibiotic_resistance def: "CTX-M-168 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-168" EXACT CARD_Short_Name [] [Term] id: ARO:3005592 name: CTX-M-169 namespace: antibiotic_resistance def: "CTX-M-169 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-169" EXACT CARD_Short_Name [] [Term] id: ARO:3005593 name: CTX-M-170 namespace: antibiotic_resistance def: "CTX-M-170 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-170" EXACT CARD_Short_Name [] [Term] id: ARO:3005594 name: CTX-M-171 namespace: antibiotic_resistance def: "CTX-M-171 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-171" EXACT CARD_Short_Name [] [Term] id: ARO:3005595 name: CTX-M-172 namespace: antibiotic_resistance def: "CTX-M-172 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-172" EXACT CARD_Short_Name [] [Term] id: ARO:3005596 name: CTX-M-173 namespace: antibiotic_resistance def: "CTX-M-173 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-173" EXACT CARD_Short_Name [] [Term] id: ARO:3005597 name: CTX-M-174 namespace: antibiotic_resistance def: "CTX-M-174 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-174" EXACT CARD_Short_Name [] [Term] id: ARO:3005598 name: CTX-M-175 namespace: antibiotic_resistance def: "CTX-M-175 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-175" EXACT CARD_Short_Name [] [Term] id: ARO:3005599 name: CTX-M-176 namespace: antibiotic_resistance def: "CTX-M-176 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-176" EXACT CARD_Short_Name [] [Term] id: ARO:3005600 name: CTX-M-177 namespace: antibiotic_resistance def: "CTX-M-177 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-177" EXACT CARD_Short_Name [] [Term] id: ARO:3005601 name: CTX-M-178 namespace: antibiotic_resistance def: "CTX-M-178 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-178" EXACT CARD_Short_Name [] [Term] id: ARO:3005602 name: CTX-M-179 namespace: antibiotic_resistance def: "CTX-M-179 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-179" EXACT CARD_Short_Name [] [Term] id: ARO:3005603 name: CTX-M-180 namespace: antibiotic_resistance def: "CTX-M-180 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-180" EXACT CARD_Short_Name [] [Term] id: ARO:3005604 name: CTX-M-181 namespace: antibiotic_resistance def: "CTX-M-181 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-181" EXACT CARD_Short_Name [] [Term] id: ARO:3005605 name: CTX-M-182 namespace: antibiotic_resistance def: "CTX-M-182 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-182" EXACT CARD_Short_Name [] [Term] id: ARO:3005606 name: CTX-M-183 namespace: antibiotic_resistance def: "CTX-M-183 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-183" EXACT CARD_Short_Name [] [Term] id: ARO:3005607 name: CTX-M-184 namespace: antibiotic_resistance def: "CTX-M-184 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-184" EXACT CARD_Short_Name [] [Term] id: ARO:3005608 name: CTX-M-185 namespace: antibiotic_resistance def: "CTX-M-185 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-185" EXACT CARD_Short_Name [] [Term] id: ARO:3005609 name: CTX-M-186 namespace: antibiotic_resistance def: "CTX-M-186 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-186" EXACT CARD_Short_Name [] [Term] id: ARO:3005610 name: CTX-M-187 namespace: antibiotic_resistance def: "CTX-M-187 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-187" EXACT CARD_Short_Name [] [Term] id: ARO:3005611 name: CTX-M-188 namespace: antibiotic_resistance def: "CTX-M-188 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-188" EXACT CARD_Short_Name [] [Term] id: ARO:3005612 name: CTX-M-189 namespace: antibiotic_resistance def: "CTX-M-189 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-189" EXACT CARD_Short_Name [] [Term] id: ARO:3005613 name: CTX-M-190 namespace: antibiotic_resistance def: "CTX-M-190 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-190" EXACT CARD_Short_Name [] [Term] id: ARO:3005614 name: CTX-M-191 namespace: antibiotic_resistance def: "CTX-M-191 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-191" EXACT CARD_Short_Name [] [Term] id: ARO:3005615 name: CTX-M-192 namespace: antibiotic_resistance def: "CTX-M-192 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-192" EXACT CARD_Short_Name [] [Term] id: ARO:3005616 name: CTX-M-193 namespace: antibiotic_resistance def: "CTX-M-193 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-193" EXACT CARD_Short_Name [] [Term] id: ARO:3005617 name: CTX-M-194 namespace: antibiotic_resistance def: "CTX-M-194 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-194" EXACT CARD_Short_Name [] [Term] id: ARO:3005618 name: CTX-M-195 namespace: antibiotic_resistance def: "CTX-M-195 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-195" EXACT CARD_Short_Name [] [Term] id: ARO:3005619 name: CTX-M-196 namespace: antibiotic_resistance def: "CTX-M-196 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-196" EXACT CARD_Short_Name [] [Term] id: ARO:3005620 name: CTX-M-197 namespace: antibiotic_resistance def: "CTX-M-197 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-197" EXACT CARD_Short_Name [] [Term] id: ARO:3005621 name: CTX-M-198 namespace: antibiotic_resistance def: "CTX-M-198 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-198" EXACT CARD_Short_Name [] [Term] id: ARO:3005622 name: CTX-M-199 namespace: antibiotic_resistance def: "CTX-M-199 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-199" EXACT CARD_Short_Name [] [Term] id: ARO:3005623 name: CTX-M-200 namespace: antibiotic_resistance def: "CTX-M-200 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-200" EXACT CARD_Short_Name [] [Term] id: ARO:3005624 name: CTX-M-201 namespace: antibiotic_resistance def: "CTX-M-201 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-201" EXACT CARD_Short_Name [] [Term] id: ARO:3005625 name: CTX-M-202 namespace: antibiotic_resistance def: "CTX-M-202 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-202" EXACT CARD_Short_Name [] [Term] id: ARO:3005626 name: CTX-M-203 namespace: antibiotic_resistance def: "CTX-M-203 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-203" EXACT CARD_Short_Name [] [Term] id: ARO:3005627 name: CTX-M-204 namespace: antibiotic_resistance def: "CTX-M-204 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-204" EXACT CARD_Short_Name [] [Term] id: ARO:3005628 name: CTX-M-205 namespace: antibiotic_resistance def: "CTX-M-205 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-205" EXACT CARD_Short_Name [] [Term] id: ARO:3005629 name: CTX-M-206 namespace: antibiotic_resistance def: "CTX-M-206 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-206" EXACT CARD_Short_Name [] [Term] id: ARO:3005630 name: CTX-M-207 namespace: antibiotic_resistance def: "CTX-M-207 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-207" EXACT CARD_Short_Name [] [Term] id: ARO:3005631 name: CTX-M-208 namespace: antibiotic_resistance def: "CTX-M-208 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-208" EXACT CARD_Short_Name [] [Term] id: ARO:3005632 name: CTX-M-209 namespace: antibiotic_resistance def: "CTX-M-209 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-209" EXACT CARD_Short_Name [] [Term] id: ARO:3005633 name: CTX-M-210 namespace: antibiotic_resistance def: "CTX-M-210 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-210" EXACT CARD_Short_Name [] [Term] id: ARO:3005634 name: CTX-M-211 namespace: antibiotic_resistance def: "CTX-M-211 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-211" EXACT CARD_Short_Name [] [Term] id: ARO:3005635 name: CTX-M-212 namespace: antibiotic_resistance def: "CTX-M-212 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-212" EXACT CARD_Short_Name [] [Term] id: ARO:3005636 name: CTX-M-213 namespace: antibiotic_resistance def: "CTX-M-213 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-213" EXACT CARD_Short_Name [] [Term] id: ARO:3005637 name: CTX-M-214 namespace: antibiotic_resistance def: "CTX-M-214 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-214" EXACT CARD_Short_Name [] [Term] id: ARO:3005638 name: CTX-M-215 namespace: antibiotic_resistance def: "CTX-M-215 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-215" EXACT CARD_Short_Name [] [Term] id: ARO:3005639 name: CTX-M-216 namespace: antibiotic_resistance def: "CTX-M-216 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-216" EXACT CARD_Short_Name [] [Term] id: ARO:3005640 name: CTX-M-217 namespace: antibiotic_resistance def: "CTX-M-217 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-217" EXACT CARD_Short_Name [] [Term] id: ARO:3005641 name: CTX-M-218 namespace: antibiotic_resistance def: "CTX-M-218 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-218" EXACT CARD_Short_Name [] [Term] id: ARO:3005642 name: CTX-M-219 namespace: antibiotic_resistance def: "CTX-M-219 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-219" EXACT CARD_Short_Name [] [Term] id: ARO:3005643 name: CTX-M-220 namespace: antibiotic_resistance def: "CTX-M-220 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-220" EXACT CARD_Short_Name [] [Term] id: ARO:3005644 name: CTX-M-221 namespace: antibiotic_resistance def: "CTX-M-221 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-221" EXACT CARD_Short_Name [] [Term] id: ARO:3005645 name: CTX-M-222 namespace: antibiotic_resistance def: "CTX-M-222 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-222" EXACT CARD_Short_Name [] [Term] id: ARO:3005646 name: CTX-M-223 namespace: antibiotic_resistance def: "CTX-M-223 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-223" EXACT CARD_Short_Name [] [Term] id: ARO:3005647 name: CTX-M-224 namespace: antibiotic_resistance def: "CTX-M-224 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-224" EXACT CARD_Short_Name [] [Term] id: ARO:3005648 name: CTX-M-225 namespace: antibiotic_resistance def: "CTX-M-225 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-225" EXACT CARD_Short_Name [] [Term] id: ARO:3005649 name: CTX-M-226 namespace: antibiotic_resistance def: "CTX-M-226 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-226" EXACT CARD_Short_Name [] [Term] id: ARO:3005650 name: CTX-M-227 namespace: antibiotic_resistance def: "CTX-M-227 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-227" EXACT CARD_Short_Name [] [Term] id: ARO:3005651 name: CTX-M-228 namespace: antibiotic_resistance def: "CTX-M-228 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-228" EXACT CARD_Short_Name [] [Term] id: ARO:3005652 name: CTX-M-229 namespace: antibiotic_resistance def: "CTX-M-229 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-229" EXACT CARD_Short_Name [] [Term] id: ARO:3005653 name: CTX-M-230 namespace: antibiotic_resistance def: "CTX-M-230 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-230" EXACT CARD_Short_Name [] [Term] id: ARO:3005654 name: CTX-M-231 namespace: antibiotic_resistance def: "CTX-M-231 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-231" EXACT CARD_Short_Name [] [Term] id: ARO:3005655 name: CTX-M-232 namespace: antibiotic_resistance def: "CTX-M-232 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-232" EXACT CARD_Short_Name [] [Term] id: ARO:3005656 name: CTX-M-233 namespace: antibiotic_resistance def: "CTX-M-233 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-233" EXACT CARD_Short_Name [] [Term] id: ARO:3005657 name: CTX-M-234 namespace: antibiotic_resistance def: "CTX-M-234 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-234" EXACT CARD_Short_Name [] [Term] id: ARO:3005658 name: CTX-M-235 namespace: antibiotic_resistance def: "CTX-M-235 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-235" EXACT CARD_Short_Name [] [Term] id: ARO:3005659 name: CTX-M-236 namespace: antibiotic_resistance def: "CTX-M-236 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-236" EXACT CARD_Short_Name [] [Term] id: ARO:3005660 name: CTX-M-237 namespace: antibiotic_resistance def: "CTX-M-237 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-237" EXACT CARD_Short_Name [] [Term] id: ARO:3005661 name: CTX-M-238 namespace: antibiotic_resistance def: "CTX-M-238 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-238" EXACT CARD_Short_Name [] [Term] id: ARO:3005662 name: CTX-M-239 namespace: antibiotic_resistance def: "CTX-M-239 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-239" EXACT CARD_Short_Name [] [Term] id: ARO:3005663 name: CTX-M-240 namespace: antibiotic_resistance def: "CTX-M-240 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-240" EXACT CARD_Short_Name [] [Term] id: ARO:3005664 name: CTX-M-241 namespace: antibiotic_resistance def: "CTX-M-241 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-241" EXACT CARD_Short_Name [] [Term] id: ARO:3005665 name: CTX-M-242 namespace: antibiotic_resistance def: "CTX-M-242 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-242" EXACT CARD_Short_Name [] [Term] id: ARO:3005666 name: CTX-M-244 namespace: antibiotic_resistance def: "CTX-M-244 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-244" EXACT CARD_Short_Name [] [Term] id: ARO:3005667 name: CTX-M-97 namespace: antibiotic_resistance def: "CTX-M-97 is a CTX-M beta-lactamase." [] is_a: ARO:3000016 ! CTX-M beta-lactamase synonym: "CTX-M-97" EXACT CARD_Short_Name [] [Term] id: ARO:3005668 name: GOB-19 namespace: antibiotic_resistance def: "GOB-19 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-19" EXACT CARD_Short_Name [] [Term] id: ARO:3005669 name: GOB-20 namespace: antibiotic_resistance def: "GOB-20 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-20" EXACT CARD_Short_Name [] [Term] id: ARO:3005670 name: GOB-21 namespace: antibiotic_resistance def: "GOB-21 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-21" EXACT CARD_Short_Name [] [Term] id: ARO:3005671 name: GOB-22 namespace: antibiotic_resistance def: "GOB-22 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-22" EXACT CARD_Short_Name [] [Term] id: ARO:3005672 name: GOB-23 namespace: antibiotic_resistance def: "GOB-23 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-23" EXACT CARD_Short_Name [] [Term] id: ARO:3005673 name: GOB-24 namespace: antibiotic_resistance def: "GOB-24 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-24" EXACT CARD_Short_Name [] [Term] id: ARO:3005674 name: GOB-25 namespace: antibiotic_resistance def: "GOB-25 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-25" EXACT CARD_Short_Name [] [Term] id: ARO:3005675 name: GOB-26 namespace: antibiotic_resistance def: "GOB-26 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-26" EXACT CARD_Short_Name [] [Term] id: ARO:3005676 name: GOB-27 namespace: antibiotic_resistance def: "GOB-27 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-27" EXACT CARD_Short_Name [] [Term] id: ARO:3005677 name: GOB-28 namespace: antibiotic_resistance def: "GOB-28 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-28" EXACT CARD_Short_Name [] [Term] id: ARO:3005678 name: GOB-29 namespace: antibiotic_resistance def: "GOB-29 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-29" EXACT CARD_Short_Name [] [Term] id: ARO:3005679 name: GOB-30 namespace: antibiotic_resistance def: "GOB-30 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-30" EXACT CARD_Short_Name [] [Term] id: ARO:3005680 name: GOB-31 namespace: antibiotic_resistance def: "GOB-31 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-31" EXACT CARD_Short_Name [] [Term] id: ARO:3005681 name: GOB-32 namespace: antibiotic_resistance def: "GOB-32 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-32" EXACT CARD_Short_Name [] [Term] id: ARO:3005682 name: GOB-33 namespace: antibiotic_resistance def: "GOB-33 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-33" EXACT CARD_Short_Name [] [Term] id: ARO:3005683 name: GOB-34 namespace: antibiotic_resistance def: "GOB-34 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-34" EXACT CARD_Short_Name [] [Term] id: ARO:3005684 name: GOB-35 namespace: antibiotic_resistance def: "GOB-35 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-35" EXACT CARD_Short_Name [] [Term] id: ARO:3005685 name: GOB-36 namespace: antibiotic_resistance def: "GOB-36 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-36" EXACT CARD_Short_Name [] [Term] id: ARO:3005686 name: GOB-37 namespace: antibiotic_resistance def: "GOB-37 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-37" EXACT CARD_Short_Name [] [Term] id: ARO:3005687 name: GOB-38 namespace: antibiotic_resistance def: "GOB-38 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-38" EXACT CARD_Short_Name [] [Term] id: ARO:3005688 name: GOB-39 namespace: antibiotic_resistance def: "GOB-39 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-39" EXACT CARD_Short_Name [] [Term] id: ARO:3005689 name: GOB-40 namespace: antibiotic_resistance def: "GOB-40 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-40" EXACT CARD_Short_Name [] [Term] id: ARO:3005690 name: GOB-41 namespace: antibiotic_resistance def: "GOB-41 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-41" EXACT CARD_Short_Name [] [Term] id: ARO:3005691 name: GOB-42 namespace: antibiotic_resistance def: "GOB-42 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-42" EXACT CARD_Short_Name [] [Term] id: ARO:3005692 name: GOB-43 namespace: antibiotic_resistance def: "GOB-43 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-43" EXACT CARD_Short_Name [] [Term] id: ARO:3005693 name: GOB-44 namespace: antibiotic_resistance def: "GOB-44 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-44" EXACT CARD_Short_Name [] [Term] id: ARO:3005694 name: GOB-45 namespace: antibiotic_resistance def: "GOB-45 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-45" EXACT CARD_Short_Name [] [Term] id: ARO:3005695 name: GOB-46 namespace: antibiotic_resistance def: "GOB-46 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-46" EXACT CARD_Short_Name [] [Term] id: ARO:3005696 name: GOB-48 namespace: antibiotic_resistance def: "GOB-48 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-48" EXACT CARD_Short_Name [] [Term] id: ARO:3005697 name: GOB-49 namespace: antibiotic_resistance def: "GOB-49 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-49" EXACT CARD_Short_Name [] [Term] id: ARO:3005698 name: GOB-50 namespace: antibiotic_resistance def: "GOB-50 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-50" EXACT CARD_Short_Name [] [Term] id: ARO:3005699 name: GOB-51 namespace: antibiotic_resistance def: "GOB-51 is a GOB beta-lactamase." [] is_a: ARO:3004212 ! GOB beta-lactamase synonym: "GOB-51" EXACT CARD_Short_Name [] [Term] id: ARO:3005700 name: NDM-30 namespace: antibiotic_resistance def: "NDM-30 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-30" EXACT CARD_Short_Name [] [Term] id: ARO:3005701 name: NDM-31 namespace: antibiotic_resistance def: "NDM-31 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-31" EXACT CARD_Short_Name [] [Term] id: ARO:3005702 name: OXA-114b namespace: antibiotic_resistance def: "OXA-114b is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114b" EXACT CARD_Short_Name [] [Term] id: ARO:3005703 name: OXA-114c namespace: antibiotic_resistance def: "OXA-114c is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114c" EXACT CARD_Short_Name [] [Term] id: ARO:3005704 name: OXA-114d namespace: antibiotic_resistance def: "OXA-114d is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114d" EXACT CARD_Short_Name [] [Term] id: ARO:3005705 name: OXA-114e namespace: antibiotic_resistance def: "OXA-114e is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114e" EXACT CARD_Short_Name [] [Term] id: ARO:3005706 name: OXA-114f namespace: antibiotic_resistance def: "OXA-114f is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114f" EXACT CARD_Short_Name [] [Term] id: ARO:3005707 name: OXA-114g namespace: antibiotic_resistance def: "OXA-114g is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114g" EXACT CARD_Short_Name [] [Term] id: ARO:3005708 name: OXA-114h namespace: antibiotic_resistance def: "OXA-114h is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114h" EXACT CARD_Short_Name [] [Term] id: ARO:3005709 name: OXA-114i namespace: antibiotic_resistance def: "OXA-114i is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114i" EXACT CARD_Short_Name [] [Term] id: ARO:3005710 name: OXA-114j namespace: antibiotic_resistance def: "OXA-114j is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114j" EXACT CARD_Short_Name [] [Term] id: ARO:3005711 name: OXA-114k namespace: antibiotic_resistance def: "OXA-114k is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114k" EXACT CARD_Short_Name [] [Term] id: ARO:3005712 name: OXA-114l namespace: antibiotic_resistance def: "OXA-114l is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114l" EXACT CARD_Short_Name [] [Term] id: ARO:3005713 name: OXA-114m namespace: antibiotic_resistance def: "OXA-114m is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114m" EXACT CARD_Short_Name [] [Term] id: ARO:3005714 name: OXA-114n namespace: antibiotic_resistance def: "OXA-114n is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114n" EXACT CARD_Short_Name [] [Term] id: ARO:3005715 name: OXA-114p namespace: antibiotic_resistance def: "OXA-114p is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114p" EXACT CARD_Short_Name [] [Term] id: ARO:3005716 name: OXA-114q namespace: antibiotic_resistance def: "OXA-114q is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114q" EXACT CARD_Short_Name [] [Term] id: ARO:3005717 name: OXA-114r namespace: antibiotic_resistance def: "OXA-114r is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114r" EXACT CARD_Short_Name [] [Term] id: ARO:3005718 name: OXA-114s namespace: antibiotic_resistance def: "OXA-114s is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114s" EXACT CARD_Short_Name [] [Term] id: ARO:3005719 name: OXA-114t namespace: antibiotic_resistance def: "OXA-114t is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114t" EXACT CARD_Short_Name [] [Term] id: ARO:3005720 name: OXA-114u namespace: antibiotic_resistance def: "OXA-114u is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114u" EXACT CARD_Short_Name [] [Term] id: ARO:3005721 name: OXA-114v namespace: antibiotic_resistance def: "OXA-114v is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114v" EXACT CARD_Short_Name [] [Term] id: ARO:3005722 name: OXA-114w namespace: antibiotic_resistance def: "OXA-114w is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114w" EXACT CARD_Short_Name [] [Term] id: ARO:3005723 name: OXA-114x namespace: antibiotic_resistance def: "OXA-114x is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-114x" EXACT CARD_Short_Name [] [Term] id: ARO:3005724 name: OXA-489 namespace: antibiotic_resistance def: "OXA-489 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-489" EXACT CARD_Short_Name [] [Term] id: ARO:3005725 name: OXA-491 namespace: antibiotic_resistance def: "OXA-491 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-491" EXACT CARD_Short_Name [] [Term] id: ARO:3005726 name: OXA-493 namespace: antibiotic_resistance def: "OXA-493 is a OXA beta-lactamase." [] is_a: ARO:3007722 ! OXA-493-like beta-lactamase synonym: "OXA-493" EXACT CARD_Short_Name [] [Term] id: ARO:3005727 name: OXA-494 namespace: antibiotic_resistance def: "OXA-494 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-494" EXACT CARD_Short_Name [] [Term] id: ARO:3005728 name: OXA-497 namespace: antibiotic_resistance def: "OXA-497 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-497" EXACT CARD_Short_Name [] [Term] id: ARO:3005729 name: OXA-498 namespace: antibiotic_resistance def: "OXA-498 is a OXA beta-lactamase." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-498" EXACT CARD_Short_Name [] [Term] id: ARO:3005730 name: OXA-500 namespace: antibiotic_resistance def: "OXA-500 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-500" EXACT CARD_Short_Name [] [Term] id: ARO:3005731 name: OXA-501 namespace: antibiotic_resistance def: "OXA-501 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-501" EXACT CARD_Short_Name [] [Term] id: ARO:3005732 name: OXA-502 namespace: antibiotic_resistance def: "OXA-502 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-502" EXACT CARD_Short_Name [] [Term] id: ARO:3005733 name: OXA-503 namespace: antibiotic_resistance def: "OXA-503 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-503" EXACT CARD_Short_Name [] [Term] id: ARO:3005734 name: OXA-504 namespace: antibiotic_resistance def: "OXA-504 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-504" EXACT CARD_Short_Name [] [Term] id: ARO:3005735 name: OXA-505 namespace: antibiotic_resistance def: "OXA-505 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-505" EXACT CARD_Short_Name [] [Term] id: ARO:3005736 name: OXA-506 namespace: antibiotic_resistance def: "OXA-506 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-506" EXACT CARD_Short_Name [] [Term] id: ARO:3005737 name: OXA-507 namespace: antibiotic_resistance def: "OXA-507 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-507" EXACT CARD_Short_Name [] [Term] id: ARO:3005738 name: OXA-508 namespace: antibiotic_resistance def: "OXA-508 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-508" EXACT CARD_Short_Name [] [Term] id: ARO:3005739 name: OXA-509 namespace: antibiotic_resistance def: "OXA-509 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-509" EXACT CARD_Short_Name [] [Term] id: ARO:3005740 name: OXA-510 namespace: antibiotic_resistance def: "OXA-510 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-510" EXACT CARD_Short_Name [] [Term] id: ARO:3005741 name: OXA-511 namespace: antibiotic_resistance def: "OXA-511 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-511" EXACT CARD_Short_Name [] [Term] id: ARO:3005742 name: OXA-512 namespace: antibiotic_resistance def: "OXA-512 is a OXA beta-lactamase." [] is_a: ARO:3007728 ! OXA-58-like beta-lactamase synonym: "OXA-512" EXACT CARD_Short_Name [] [Term] id: ARO:3005743 name: OXA-513 namespace: antibiotic_resistance def: "OXA-513 is a OXA beta-lactamase." [] is_a: ARO:3007716 ! OXA-364-like beta-lactamase synonym: "OXA-513" EXACT CARD_Short_Name [] [Term] id: ARO:3005744 name: OXA-514 namespace: antibiotic_resistance def: "OXA-514 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-514" EXACT CARD_Short_Name [] [Term] id: ARO:3005745 name: OXA-515 namespace: antibiotic_resistance def: "OXA-515 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-515" EXACT CARD_Short_Name [] [Term] id: ARO:3005746 name: OXA-516 namespace: antibiotic_resistance def: "OXA-516 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-516" EXACT CARD_Short_Name [] [Term] id: ARO:3005747 name: OXA-517 namespace: antibiotic_resistance def: "OXA-517 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-517" EXACT CARD_Short_Name [] [Term] id: ARO:3005748 name: OXA-518 namespace: antibiotic_resistance def: "OXA-518 is a OXA beta-lactamase." [] is_a: ARO:3007722 ! OXA-493-like beta-lactamase synonym: "OXA-518" EXACT CARD_Short_Name [] [Term] id: ARO:3005749 name: OXA-519 namespace: antibiotic_resistance def: "OXA-519 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-519" EXACT CARD_Short_Name [] [Term] id: ARO:3005750 name: OXA-520 namespace: antibiotic_resistance def: "OXA-520 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-520" EXACT CARD_Short_Name [] [Term] id: ARO:3005751 name: OXA-521 namespace: antibiotic_resistance def: "OXA-521 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-521" EXACT CARD_Short_Name [] [Term] id: ARO:3005752 name: OXA-522 namespace: antibiotic_resistance def: "OXA-522 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-522" EXACT CARD_Short_Name [] [Term] id: ARO:3005753 name: OXA-523 namespace: antibiotic_resistance def: "OXA-523 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-523" EXACT CARD_Short_Name [] [Term] id: ARO:3005754 name: OXA-524 namespace: antibiotic_resistance def: "OXA-524 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-524" EXACT CARD_Short_Name [] [Term] id: ARO:3005755 name: OXA-525 namespace: antibiotic_resistance def: "OXA-525 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-525" EXACT CARD_Short_Name [] [Term] id: ARO:3005756 name: OXA-526 namespace: antibiotic_resistance def: "OXA-526 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-526" EXACT CARD_Short_Name [] [Term] id: ARO:3005757 name: OXA-527 namespace: antibiotic_resistance def: "OXA-527 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-527" EXACT CARD_Short_Name [] [Term] id: ARO:3005758 name: OXA-528 namespace: antibiotic_resistance def: "OXA-528 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-528" EXACT CARD_Short_Name [] [Term] id: ARO:3005759 name: OXA-529 namespace: antibiotic_resistance def: "OXA-529 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-529" EXACT CARD_Short_Name [] [Term] id: ARO:3005760 name: OXA-530 namespace: antibiotic_resistance def: "OXA-530 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-530" EXACT CARD_Short_Name [] [Term] id: ARO:3005761 name: OXA-531 namespace: antibiotic_resistance def: "OXA-531 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-531" EXACT CARD_Short_Name [] [Term] id: ARO:3005762 name: OXA-532 namespace: antibiotic_resistance def: "OXA-532 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-532" EXACT CARD_Short_Name [] [Term] id: ARO:3005763 name: OXA-533 namespace: antibiotic_resistance def: "OXA-533 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-533" EXACT CARD_Short_Name [] [Term] id: ARO:3005764 name: OXA-534 namespace: antibiotic_resistance def: "OXA-534 is a OXA beta-lactamase." [] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-534" EXACT CARD_Short_Name [] [Term] id: ARO:3005765 name: OXA-536 namespace: antibiotic_resistance def: "OXA-536 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-536" EXACT CARD_Short_Name [] [Term] id: ARO:3005766 name: OXA-537 namespace: antibiotic_resistance def: "OXA-537 is a OXA beta-lactamase." [] is_a: ARO:3007700 ! OXA-134-like beta-lactamase synonym: "OXA-537" EXACT CARD_Short_Name [] [Term] id: ARO:3005767 name: OXA-538 namespace: antibiotic_resistance def: "OXA-538 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-538" EXACT CARD_Short_Name [] [Term] id: ARO:3005768 name: OXA-542 namespace: antibiotic_resistance def: "OXA-542 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-542" EXACT CARD_Short_Name [] [Term] id: ARO:3005769 name: OXA-545 namespace: antibiotic_resistance def: "OXA-545 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-545" EXACT CARD_Short_Name [] [Term] id: ARO:3005770 name: OXA-546 namespace: antibiotic_resistance def: "OXA-546 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-546" EXACT CARD_Short_Name [] [Term] id: ARO:3005771 name: OXA-547 namespace: antibiotic_resistance def: "OXA-547 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-547" EXACT CARD_Short_Name [] [Term] id: ARO:3005772 name: OXA-548 namespace: antibiotic_resistance def: "OXA-548 is a OXA beta-lactamase." [] is_a: ARO:3007726 ! OXA-548-like beta-lactamase synonym: "OXA-548" EXACT CARD_Short_Name [] [Term] id: ARO:3005773 name: OXA-549 namespace: antibiotic_resistance def: "OXA-549 is a OXA beta-lactamase." [] is_a: ARO:3007726 ! OXA-548-like beta-lactamase synonym: "OXA-549" EXACT CARD_Short_Name [] [Term] id: ARO:3005774 name: OXA-550 namespace: antibiotic_resistance def: "OXA-550 is a OXA beta-lactamase." [] is_a: ARO:3007726 ! OXA-548-like beta-lactamase synonym: "OXA-550" EXACT CARD_Short_Name [] [Term] id: ARO:3005775 name: OXA-551 namespace: antibiotic_resistance def: "OXA-551 is a OXA beta-lactamase." [] is_a: ARO:3007726 ! OXA-548-like beta-lactamase synonym: "OXA-551" EXACT CARD_Short_Name [] [Term] id: ARO:3005776 name: OXA-552 namespace: antibiotic_resistance def: "OXA-552 is a OXA beta-lactamase." [] is_a: ARO:3007726 ! OXA-548-like beta-lactamase synonym: "OXA-552" EXACT CARD_Short_Name [] [Term] id: ARO:3005777 name: OXA-553 namespace: antibiotic_resistance def: "OXA-553 is a OXA beta-lactamase." [] is_a: ARO:3007726 ! OXA-548-like beta-lactamase synonym: "OXA-553" EXACT CARD_Short_Name [] [Term] id: ARO:3005778 name: OXA-554 namespace: antibiotic_resistance def: "OXA-554 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-554" EXACT CARD_Short_Name [] [Term] id: ARO:3005779 name: OXA-555 namespace: antibiotic_resistance def: "OXA-555 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-555" EXACT CARD_Short_Name [] [Term] id: ARO:3005780 name: OXA-556 namespace: antibiotic_resistance def: "OXA-556 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-556" EXACT CARD_Short_Name [] [Term] id: ARO:3005781 name: OXA-557 namespace: antibiotic_resistance def: "OXA-557 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-557" EXACT CARD_Short_Name [] [Term] id: ARO:3005782 name: OXA-558 namespace: antibiotic_resistance def: "OXA-558 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-558" EXACT CARD_Short_Name [] [Term] id: ARO:3005783 name: OXA-559 namespace: antibiotic_resistance def: "OXA-559 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-559" EXACT CARD_Short_Name [] [Term] id: ARO:3005784 name: OXA-560 namespace: antibiotic_resistance def: "OXA-560 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-560" EXACT CARD_Short_Name [] [Term] id: ARO:3005785 name: OXA-561 namespace: antibiotic_resistance def: "OXA-561 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-561" EXACT CARD_Short_Name [] [Term] id: ARO:3005786 name: OXA-562 namespace: antibiotic_resistance def: "OXA-562 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-562" EXACT CARD_Short_Name [] [Term] id: ARO:3005787 name: OXA-563 namespace: antibiotic_resistance def: "OXA-563 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-563" EXACT CARD_Short_Name [] [Term] id: ARO:3005788 name: OXA-564 namespace: antibiotic_resistance def: "OXA-564 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-564" EXACT CARD_Short_Name [] [Term] id: ARO:3005789 name: OXA-565 namespace: antibiotic_resistance def: "OXA-565 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-565" EXACT CARD_Short_Name [] [Term] id: ARO:3005790 name: OXA-566 namespace: antibiotic_resistance def: "OXA-566 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-566" EXACT CARD_Short_Name [] [Term] id: ARO:3005791 name: OXA-567 namespace: antibiotic_resistance def: "OXA-567 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-567" EXACT CARD_Short_Name [] [Term] id: ARO:3005792 name: OXA-568 namespace: antibiotic_resistance def: "OXA-568 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-568" EXACT CARD_Short_Name [] [Term] id: ARO:3005793 name: OXA-569 namespace: antibiotic_resistance def: "OXA-569 is a OXA beta-lactamase." [] is_a: ARO:3007708 ! OXA-22-like beta-lactamase synonym: "OXA-569" EXACT CARD_Short_Name [] [Term] id: ARO:3005794 name: OXA-572 namespace: antibiotic_resistance def: "OXA-572 is a OXA beta-lactamase." [] is_a: ARO:3007708 ! OXA-22-like beta-lactamase synonym: "OXA-572" EXACT CARD_Short_Name [] [Term] id: ARO:3005795 name: OXA-574 namespace: antibiotic_resistance def: "OXA-574 is a OXA beta-lactamase." [] is_a: ARO:3007708 ! OXA-22-like beta-lactamase synonym: "OXA-574" EXACT CARD_Short_Name [] [Term] id: ARO:3005796 name: OXA-575 namespace: antibiotic_resistance def: "OXA-575 is a OXA beta-lactamase." [] is_a: ARO:3007707 ! OXA-214-like beta-lactamase synonym: "OXA-575" EXACT CARD_Short_Name [] [Term] id: ARO:3005797 name: OXA-576 namespace: antibiotic_resistance def: "OXA-576 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-576" EXACT CARD_Short_Name [] [Term] id: ARO:3005798 name: OXA-577 namespace: antibiotic_resistance def: "OXA-577 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-577" EXACT CARD_Short_Name [] [Term] id: ARO:3005799 name: OXA-578 namespace: antibiotic_resistance def: "OXA-578 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-578" EXACT CARD_Short_Name [] [Term] id: ARO:3005800 name: OXA-579 namespace: antibiotic_resistance def: "OXA-579 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-579" EXACT CARD_Short_Name [] [Term] id: ARO:3005801 name: OXA-580 namespace: antibiotic_resistance def: "OXA-580 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-580" EXACT CARD_Short_Name [] [Term] id: ARO:3005802 name: OXA-581 namespace: antibiotic_resistance def: "OXA-581 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-581" EXACT CARD_Short_Name [] [Term] id: ARO:3005803 name: OXA-582 namespace: antibiotic_resistance def: "OXA-582 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-582" EXACT CARD_Short_Name [] [Term] id: ARO:3005804 name: OXA-583 namespace: antibiotic_resistance def: "OXA-583 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-583" EXACT CARD_Short_Name [] [Term] id: ARO:3005805 name: OXA-584 namespace: antibiotic_resistance def: "OXA-584 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-584" EXACT CARD_Short_Name [] [Term] id: ARO:3005806 name: OXA-585 namespace: antibiotic_resistance def: "OXA-585 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-585" EXACT CARD_Short_Name [] [Term] id: ARO:3005807 name: OXA-586 namespace: antibiotic_resistance def: "OXA-586 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-586" EXACT CARD_Short_Name [] [Term] id: ARO:3005808 name: OXA-587 namespace: antibiotic_resistance def: "OXA-587 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-587" EXACT CARD_Short_Name [] [Term] id: ARO:3005809 name: OXA-588 namespace: antibiotic_resistance def: "OXA-588 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-588" EXACT CARD_Short_Name [] [Term] id: ARO:3005810 name: OXA-589 namespace: antibiotic_resistance def: "OXA-589 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-589" EXACT CARD_Short_Name [] [Term] id: ARO:3005811 name: OXA-590 namespace: antibiotic_resistance def: "OXA-590 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-590" EXACT CARD_Short_Name [] [Term] id: ARO:3005812 name: OXA-591 namespace: antibiotic_resistance def: "OXA-591 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-591" EXACT CARD_Short_Name [] [Term] id: ARO:3005813 name: OXA-592 namespace: antibiotic_resistance def: "OXA-592 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-592" EXACT CARD_Short_Name [] [Term] id: ARO:3005814 name: OXA-593 namespace: antibiotic_resistance def: "OXA-593 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-593" EXACT CARD_Short_Name [] [Term] id: ARO:3005815 name: OXA-594 namespace: antibiotic_resistance def: "OXA-594 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-594" EXACT CARD_Short_Name [] [Term] id: ARO:3005816 name: OXA-595 namespace: antibiotic_resistance def: "OXA-595 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-595" EXACT CARD_Short_Name [] [Term] id: ARO:3005817 name: OXA-596 namespace: antibiotic_resistance def: "OXA-596 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-596" EXACT CARD_Short_Name [] [Term] id: ARO:3005818 name: OXA-597 namespace: antibiotic_resistance def: "OXA-597 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-597" EXACT CARD_Short_Name [] [Term] id: ARO:3005819 name: OXA-598 namespace: antibiotic_resistance def: "OXA-598 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-598" EXACT CARD_Short_Name [] [Term] id: ARO:3005820 name: OXA-599 namespace: antibiotic_resistance def: "OXA-599 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-599" EXACT CARD_Short_Name [] [Term] id: ARO:3005821 name: OXA-600 namespace: antibiotic_resistance def: "OXA-600 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-600" EXACT CARD_Short_Name [] [Term] id: ARO:3005822 name: OXA-601 namespace: antibiotic_resistance def: "OXA-601 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-601" EXACT CARD_Short_Name [] [Term] id: ARO:3005823 name: OXA-602 namespace: antibiotic_resistance def: "OXA-602 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-602" EXACT CARD_Short_Name [] [Term] id: ARO:3005824 name: OXA-603 namespace: antibiotic_resistance def: "OXA-603 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-603" EXACT CARD_Short_Name [] [Term] id: ARO:3005825 name: OXA-604 namespace: antibiotic_resistance def: "OXA-604 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-604" EXACT CARD_Short_Name [] [Term] id: ARO:3005826 name: OXA-605 namespace: antibiotic_resistance def: "OXA-605 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-605" EXACT CARD_Short_Name [] [Term] id: ARO:3005827 name: OXA-606 namespace: antibiotic_resistance def: "OXA-606 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-606" EXACT CARD_Short_Name [] [Term] id: ARO:3005828 name: OXA-607 namespace: antibiotic_resistance def: "OXA-607 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-607" EXACT CARD_Short_Name [] [Term] id: ARO:3005829 name: OXA-608 namespace: antibiotic_resistance def: "OXA-608 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-608" EXACT CARD_Short_Name [] [Term] id: ARO:3005830 name: OXA-609 namespace: antibiotic_resistance def: "OXA-609 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-609" EXACT CARD_Short_Name [] [Term] id: ARO:3005831 name: OXA-610 namespace: antibiotic_resistance def: "OXA-610 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-610" EXACT CARD_Short_Name [] [Term] id: ARO:3005832 name: OXA-611 namespace: antibiotic_resistance def: "OXA-611 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-611" EXACT CARD_Short_Name [] [Term] id: ARO:3005833 name: OXA-612 namespace: antibiotic_resistance def: "OXA-612 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-612" EXACT CARD_Short_Name [] [Term] id: ARO:3005834 name: OXA-613 namespace: antibiotic_resistance def: "OXA-613 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-613" EXACT CARD_Short_Name [] [Term] id: ARO:3005835 name: OXA-614 namespace: antibiotic_resistance def: "OXA-614 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-614" EXACT CARD_Short_Name [] [Term] id: ARO:3005836 name: OXA-615 namespace: antibiotic_resistance def: "OXA-615 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-615" EXACT CARD_Short_Name [] [Term] id: ARO:3005837 name: OXA-616 namespace: antibiotic_resistance def: "OXA-616 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-616" EXACT CARD_Short_Name [] [Term] id: ARO:3005838 name: OXA-617 namespace: antibiotic_resistance def: "OXA-617 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-617" EXACT CARD_Short_Name [] [Term] id: ARO:3005839 name: OXA-618 namespace: antibiotic_resistance def: "OXA-618 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-618" EXACT CARD_Short_Name [] [Term] id: ARO:3005840 name: OXA-619 namespace: antibiotic_resistance def: "OXA-619 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-619" EXACT CARD_Short_Name [] [Term] id: ARO:3005841 name: OXA-620 namespace: antibiotic_resistance def: "OXA-620 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-620" EXACT CARD_Short_Name [] [Term] id: ARO:3005842 name: OXA-621 namespace: antibiotic_resistance def: "OXA-621 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-621" EXACT CARD_Short_Name [] [Term] id: ARO:3005843 name: OXA-622 namespace: antibiotic_resistance def: "OXA-622 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-622" EXACT CARD_Short_Name [] [Term] id: ARO:3005844 name: OXA-623 namespace: antibiotic_resistance def: "OXA-623 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-623" EXACT CARD_Short_Name [] [Term] id: ARO:3005845 name: OXA-624 namespace: antibiotic_resistance def: "OXA-624 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-624" EXACT CARD_Short_Name [] [Term] id: ARO:3005846 name: OXA-625 namespace: antibiotic_resistance def: "OXA-625 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-625" EXACT CARD_Short_Name [] [Term] id: ARO:3005847 name: OXA-626 namespace: antibiotic_resistance def: "OXA-626 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-626" EXACT CARD_Short_Name [] [Term] id: ARO:3005848 name: OXA-627 namespace: antibiotic_resistance def: "OXA-627 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-627" EXACT CARD_Short_Name [] [Term] id: ARO:3005849 name: OXA-628 namespace: antibiotic_resistance def: "OXA-628 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-628" EXACT CARD_Short_Name [] [Term] id: ARO:3005850 name: OXA-629 namespace: antibiotic_resistance def: "OXA-629 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-629" EXACT CARD_Short_Name [] [Term] id: ARO:3005851 name: OXA-630 namespace: antibiotic_resistance def: "OXA-630 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-630" EXACT CARD_Short_Name [] [Term] id: ARO:3005852 name: OXA-631 namespace: antibiotic_resistance def: "OXA-631 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-631" EXACT CARD_Short_Name [] [Term] id: ARO:3005853 name: OXA-632 namespace: antibiotic_resistance def: "OXA-632 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-632" EXACT CARD_Short_Name [] [Term] id: ARO:3005854 name: OXA-633 namespace: antibiotic_resistance def: "OXA-633 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-633" EXACT CARD_Short_Name [] [Term] id: ARO:3005855 name: OXA-634 namespace: antibiotic_resistance def: "OXA-634 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-634" EXACT CARD_Short_Name [] [Term] id: ARO:3005856 name: OXA-635 namespace: antibiotic_resistance def: "OXA-635 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-635" EXACT CARD_Short_Name [] [Term] id: ARO:3005857 name: OXA-636 namespace: antibiotic_resistance def: "OXA-636 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-636" EXACT CARD_Short_Name [] [Term] id: ARO:3005858 name: OXA-637 namespace: antibiotic_resistance def: "OXA-637 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-637" EXACT CARD_Short_Name [] [Term] id: ARO:3005859 name: OXA-638 namespace: antibiotic_resistance def: "OXA-638 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-638" EXACT CARD_Short_Name [] [Term] id: ARO:3005860 name: OXA-639 namespace: antibiotic_resistance def: "OXA-639 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-639" EXACT CARD_Short_Name [] [Term] id: ARO:3005861 name: OXA-640 namespace: antibiotic_resistance def: "OXA-640 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-640" EXACT CARD_Short_Name [] [Term] id: ARO:3005862 name: OXA-642 namespace: antibiotic_resistance def: "OXA-642 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-642" EXACT CARD_Short_Name [] [Term] id: ARO:3005863 name: OXA-643 namespace: antibiotic_resistance def: "OXA-643 is a OXA beta-lactamase." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-643" EXACT CARD_Short_Name [] [Term] id: ARO:3005864 name: OXA-644 namespace: antibiotic_resistance def: "OXA-644 is a OXA beta-lactamase." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-644" EXACT CARD_Short_Name [] [Term] id: ARO:3005865 name: OXA-645 namespace: antibiotic_resistance def: "OXA-645 is a OXA beta-lactamase." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-645" EXACT CARD_Short_Name [] [Term] id: ARO:3005866 name: OXA-650 namespace: antibiotic_resistance def: "OXA-650 is a OXA beta-lactamase." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-650" EXACT CARD_Short_Name [] [Term] id: ARO:3005867 name: OXA-651 namespace: antibiotic_resistance def: "OXA-651 is a OXA beta-lactamase." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-651" EXACT CARD_Short_Name [] [Term] id: ARO:3005868 name: OXA-652 namespace: antibiotic_resistance def: "OXA-652 is a OXA beta-lactamase." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-652" EXACT CARD_Short_Name [] [Term] id: ARO:3005869 name: OXA-654 namespace: antibiotic_resistance def: "OXA-654 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-654" EXACT CARD_Short_Name [] [Term] id: ARO:3005870 name: OXA-655 namespace: antibiotic_resistance def: "OXA-655 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-655" EXACT CARD_Short_Name [] [Term] id: ARO:3005871 name: OXA-656 namespace: antibiotic_resistance def: "OXA-656 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-656" EXACT CARD_Short_Name [] [Term] id: ARO:3005872 name: OXA-657 namespace: antibiotic_resistance def: "OXA-657 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-657" EXACT CARD_Short_Name [] [Term] id: ARO:3005873 name: OXA-658 namespace: antibiotic_resistance def: "OXA-658 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-658" EXACT CARD_Short_Name [] [Term] id: ARO:3005874 name: OXA-659 namespace: antibiotic_resistance def: "OXA-659 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-659" EXACT CARD_Short_Name [] [Term] id: ARO:3005875 name: OXA-660 namespace: antibiotic_resistance def: "OXA-660 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-660" EXACT CARD_Short_Name [] [Term] id: ARO:3005876 name: OXA-661 namespace: antibiotic_resistance def: "OXA-661 is a OXA beta-lactamase." [] is_a: ARO:3007712 ! OXA-266-like beta-lactamase synonym: "OXA-661" EXACT CARD_Short_Name [] [Term] id: ARO:3005877 name: OXA-662 namespace: antibiotic_resistance def: "OXA-662 is a OXA beta-lactamase." [] is_a: ARO:3007705 ! OXA-211-like beta-lactamase synonym: "OXA-662" EXACT CARD_Short_Name [] [Term] id: ARO:3005878 name: OXA-666 namespace: antibiotic_resistance def: "OXA-666 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-666" EXACT CARD_Short_Name [] [Term] id: ARO:3005879 name: OXA-667 namespace: antibiotic_resistance def: "OXA-667 is a OXA beta-lactamase." [] is_a: ARO:3007713 ! OXA-274-like beta-lactamase synonym: "OXA-667" EXACT CARD_Short_Name [] [Term] id: ARO:3005880 name: OXA-669 namespace: antibiotic_resistance def: "OXA-669 is a OXA beta-lactamase." [] is_a: ARO:3007713 ! OXA-274-like beta-lactamase synonym: "OXA-669" EXACT CARD_Short_Name [] [Term] id: ARO:3005881 name: OXA-670 namespace: antibiotic_resistance def: "OXA-670 is a OXA beta-lactamase." [] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-670" EXACT CARD_Short_Name [] [Term] id: ARO:3005882 name: OXA-674 namespace: antibiotic_resistance def: "OXA-674 is a OXA beta-lactamase." [] is_a: ARO:3007714 ! OXA-286-like beta-lactamase synonym: "OXA-674" EXACT CARD_Short_Name [] [Term] id: ARO:3005883 name: OXA-675 namespace: antibiotic_resistance def: "OXA-675 is a OXA beta-lactamase." [] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-675" EXACT CARD_Short_Name [] [Term] id: ARO:3005884 name: OXA-676 namespace: antibiotic_resistance def: "OXA-676 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-676" EXACT CARD_Short_Name [] [Term] id: ARO:3005885 name: OXA-677 namespace: antibiotic_resistance def: "OXA-677 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-677" EXACT CARD_Short_Name [] [Term] id: ARO:3005886 name: OXA-678 namespace: antibiotic_resistance def: "OXA-678 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-678" EXACT CARD_Short_Name [] [Term] id: ARO:3005887 name: OXA-679 namespace: antibiotic_resistance def: "OXA-679 is a OXA beta-lactamase." [] is_a: ARO:3007733 ! OXA-679-like beta-lactamase synonym: "OXA-679" EXACT CARD_Short_Name [] [Term] id: ARO:3005888 name: OXA-680 namespace: antibiotic_resistance def: "OXA-680 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-680" EXACT CARD_Short_Name [] [Term] id: ARO:3005889 name: OXA-682 namespace: antibiotic_resistance def: "OXA-682 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-682" EXACT CARD_Short_Name [] [Term] id: ARO:3005890 name: OXA-683 namespace: antibiotic_resistance def: "OXA-683 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-683" EXACT CARD_Short_Name [] [Term] id: ARO:3005891 name: OXA-684 namespace: antibiotic_resistance def: "OXA-684 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-684" EXACT CARD_Short_Name [] [Term] id: ARO:3005892 name: OXA-685 namespace: antibiotic_resistance def: "OXA-685 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-685" EXACT CARD_Short_Name [] [Term] id: ARO:3005893 name: OXA-686 namespace: antibiotic_resistance def: "OXA-686 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-686" EXACT CARD_Short_Name [] [Term] id: ARO:3005894 name: OXA-687 namespace: antibiotic_resistance def: "OXA-687 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-687" EXACT CARD_Short_Name [] [Term] id: ARO:3005895 name: OXA-688 namespace: antibiotic_resistance def: "OXA-688 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-688" EXACT CARD_Short_Name [] [Term] id: ARO:3005896 name: OXA-689 namespace: antibiotic_resistance def: "OXA-689 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-689" EXACT CARD_Short_Name [] [Term] id: ARO:3005897 name: OXA-690 namespace: antibiotic_resistance def: "OXA-690 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-690" EXACT CARD_Short_Name [] [Term] id: ARO:3005898 name: OXA-691 namespace: antibiotic_resistance def: "OXA-691 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-691" EXACT CARD_Short_Name [] [Term] id: ARO:3005899 name: OXA-692 namespace: antibiotic_resistance def: "OXA-692 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-692" EXACT CARD_Short_Name [] [Term] id: ARO:3005900 name: OXA-693 namespace: antibiotic_resistance def: "OXA-693 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-693" EXACT CARD_Short_Name [] [Term] id: ARO:3005901 name: OXA-694 namespace: antibiotic_resistance def: "OXA-694 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-694" EXACT CARD_Short_Name [] [Term] id: ARO:3005902 name: OXA-695 namespace: antibiotic_resistance def: "OXA-695 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-695" EXACT CARD_Short_Name [] [Term] id: ARO:3005903 name: OXA-696 namespace: antibiotic_resistance def: "OXA-696 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-696" EXACT CARD_Short_Name [] [Term] id: ARO:3005904 name: OXA-697 namespace: antibiotic_resistance def: "OXA-697 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-697" EXACT CARD_Short_Name [] [Term] id: ARO:3005905 name: OXA-698 namespace: antibiotic_resistance def: "OXA-698 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-698" EXACT CARD_Short_Name [] [Term] id: ARO:3005906 name: OXA-699 namespace: antibiotic_resistance def: "OXA-699 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-699" EXACT CARD_Short_Name [] [Term] id: ARO:3005907 name: OXA-700 namespace: antibiotic_resistance def: "OXA-700 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-700" EXACT CARD_Short_Name [] [Term] id: ARO:3005908 name: OXA-701 namespace: antibiotic_resistance def: "OXA-701 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-701" EXACT CARD_Short_Name [] [Term] id: ARO:3005909 name: OXA-702 namespace: antibiotic_resistance def: "OXA-702 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-702" EXACT CARD_Short_Name [] [Term] id: ARO:3005910 name: OXA-703 namespace: antibiotic_resistance def: "OXA-703 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-703" EXACT CARD_Short_Name [] [Term] id: ARO:3005911 name: OXA-704 namespace: antibiotic_resistance def: "OXA-704 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-704" EXACT CARD_Short_Name [] [Term] id: ARO:3005912 name: OXA-705 namespace: antibiotic_resistance def: "OXA-705 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-705" EXACT CARD_Short_Name [] [Term] id: ARO:3005913 name: OXA-706 namespace: antibiotic_resistance def: "OXA-706 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-706" EXACT CARD_Short_Name [] [Term] id: ARO:3005914 name: OXA-707 namespace: antibiotic_resistance def: "OXA-707 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-707" EXACT CARD_Short_Name [] [Term] id: ARO:3005915 name: OXA-708 namespace: antibiotic_resistance def: "OXA-708 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-708" EXACT CARD_Short_Name [] [Term] id: ARO:3005916 name: OXA-709 namespace: antibiotic_resistance def: "OXA-709 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-709" EXACT CARD_Short_Name [] [Term] id: ARO:3005917 name: OXA-710 namespace: antibiotic_resistance def: "OXA-710 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-710" EXACT CARD_Short_Name [] [Term] id: ARO:3005918 name: OXA-711 namespace: antibiotic_resistance def: "OXA-711 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-711" EXACT CARD_Short_Name [] [Term] id: ARO:3005919 name: OXA-712 namespace: antibiotic_resistance def: "OXA-712 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-712" EXACT CARD_Short_Name [] [Term] id: ARO:3005920 name: OXA-713 namespace: antibiotic_resistance def: "OXA-713 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-713" EXACT CARD_Short_Name [] [Term] id: ARO:3005921 name: OXA-714 namespace: antibiotic_resistance def: "OXA-714 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-714" EXACT CARD_Short_Name [] [Term] id: ARO:3005922 name: OXA-715 namespace: antibiotic_resistance def: "OXA-715 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-715" EXACT CARD_Short_Name [] [Term] id: ARO:3005923 name: OXA-716 namespace: antibiotic_resistance def: "OXA-716 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-716" EXACT CARD_Short_Name [] [Term] id: ARO:3005924 name: OXA-717 namespace: antibiotic_resistance def: "OXA-717 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-717" EXACT CARD_Short_Name [] [Term] id: ARO:3005925 name: OXA-718 namespace: antibiotic_resistance def: "OXA-718 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-718" EXACT CARD_Short_Name [] [Term] id: ARO:3005926 name: OXA-719 namespace: antibiotic_resistance def: "OXA-719 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-719" EXACT CARD_Short_Name [] [Term] id: ARO:3005927 name: OXA-720 namespace: antibiotic_resistance def: "OXA-720 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-720" EXACT CARD_Short_Name [] [Term] id: ARO:3005928 name: OXA-721 namespace: antibiotic_resistance def: "OXA-721 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-721" EXACT CARD_Short_Name [] [Term] id: ARO:3005929 name: OXA-722 namespace: antibiotic_resistance def: "OXA-722 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-722" EXACT CARD_Short_Name [] [Term] id: ARO:3005930 name: OXA-723 namespace: antibiotic_resistance def: "OXA-723 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-723" EXACT CARD_Short_Name [] [Term] id: ARO:3005931 name: OXA-726 namespace: antibiotic_resistance def: "OXA-726 is a OXA beta-lactamase." [] is_a: ARO:3007699 ! OXA-12-like beta-lactamase synonym: "OXA-726" EXACT CARD_Short_Name [] [Term] id: ARO:3005932 name: OXA-727 namespace: antibiotic_resistance def: "OXA-727 is a OXA beta-lactamase." [] is_a: ARO:3007734 ! OXA-727-like beta-lactamase synonym: "OXA-727" EXACT CARD_Short_Name [] [Term] id: ARO:3005933 name: OXA-728 namespace: antibiotic_resistance def: "OXA-728 is a OXA beta-lactamase." [] is_a: ARO:3007734 ! OXA-727-like beta-lactamase synonym: "OXA-728" EXACT CARD_Short_Name [] [Term] id: ARO:3005934 name: OXA-729 namespace: antibiotic_resistance def: "OXA-729 is a OXA beta-lactamase." [] is_a: ARO:3007727 ! OXA-55-like beta-lactamase synonym: "OXA-729" EXACT CARD_Short_Name [] [Term] id: ARO:3005935 name: OXA-730 namespace: antibiotic_resistance def: "OXA-730 is a OXA beta-lactamase." [] is_a: ARO:3007733 ! OXA-679-like beta-lactamase synonym: "OXA-730" EXACT CARD_Short_Name [] [Term] id: ARO:3005936 name: OXA-731 namespace: antibiotic_resistance def: "OXA-731 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-731" EXACT CARD_Short_Name [] [Term] id: ARO:3005937 name: OXA-732 namespace: antibiotic_resistance def: "OXA-732 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-732" EXACT CARD_Short_Name [] [Term] id: ARO:3005938 name: OXA-733 namespace: antibiotic_resistance def: "OXA-733 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-733" EXACT CARD_Short_Name [] [Term] id: ARO:3005939 name: OXA-734 namespace: antibiotic_resistance def: "OXA-734 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-734" EXACT CARD_Short_Name [] [Term] id: ARO:3005940 name: OXA-735 namespace: antibiotic_resistance def: "OXA-735 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-735" EXACT CARD_Short_Name [] [Term] id: ARO:3005941 name: OXA-736 namespace: antibiotic_resistance def: "OXA-736 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-736" EXACT CARD_Short_Name [] [Term] id: ARO:3005942 name: OXA-738 namespace: antibiotic_resistance def: "OXA-738 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-738" EXACT CARD_Short_Name [] [Term] id: ARO:3005943 name: OXA-739 namespace: antibiotic_resistance def: "OXA-739 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-739" EXACT CARD_Short_Name [] [Term] id: ARO:3005944 name: OXA-740 namespace: antibiotic_resistance def: "OXA-740 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-740" EXACT CARD_Short_Name [] [Term] id: ARO:3005945 name: OXA-741 namespace: antibiotic_resistance def: "OXA-741 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-741" EXACT CARD_Short_Name [] [Term] id: ARO:3005946 name: OXA-742 namespace: antibiotic_resistance def: "OXA-742 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-742" EXACT CARD_Short_Name [] [Term] id: ARO:3005947 name: OXA-743 namespace: antibiotic_resistance def: "OXA-743 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-743" EXACT CARD_Short_Name [] [Term] id: ARO:3005948 name: OXA-744 namespace: antibiotic_resistance def: "OXA-744 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-744" EXACT CARD_Short_Name [] [Term] id: ARO:3005949 name: OXA-745 namespace: antibiotic_resistance def: "OXA-745 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-745" EXACT CARD_Short_Name [] [Term] id: ARO:3005950 name: OXA-746 namespace: antibiotic_resistance def: "OXA-746 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-746" EXACT CARD_Short_Name [] [Term] id: ARO:3005951 name: OXA-747 namespace: antibiotic_resistance def: "OXA-747 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-747" EXACT CARD_Short_Name [] [Term] id: ARO:3005952 name: OXA-748 namespace: antibiotic_resistance def: "OXA-748 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-748" EXACT CARD_Short_Name [] [Term] id: ARO:3005953 name: OXA-749 namespace: antibiotic_resistance def: "OXA-749 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-749" EXACT CARD_Short_Name [] [Term] id: ARO:3005954 name: OXA-750 namespace: antibiotic_resistance def: "OXA-750 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-750" EXACT CARD_Short_Name [] [Term] id: ARO:3005955 name: OXA-751 namespace: antibiotic_resistance def: "OXA-751 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-751" EXACT CARD_Short_Name [] [Term] id: ARO:3005956 name: OXA-752 namespace: antibiotic_resistance def: "OXA-752 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-752" EXACT CARD_Short_Name [] [Term] id: ARO:3005957 name: OXA-753 namespace: antibiotic_resistance def: "OXA-753 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-753" EXACT CARD_Short_Name [] [Term] id: ARO:3005958 name: OXA-754 namespace: antibiotic_resistance def: "OXA-754 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-754" EXACT CARD_Short_Name [] [Term] id: ARO:3005959 name: OXA-755 namespace: antibiotic_resistance def: "OXA-755 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-755" EXACT CARD_Short_Name [] [Term] id: ARO:3005960 name: OXA-756 namespace: antibiotic_resistance def: "OXA-756 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-756" EXACT CARD_Short_Name [] [Term] id: ARO:3005961 name: OXA-757 namespace: antibiotic_resistance def: "OXA-757 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-757" EXACT CARD_Short_Name [] [Term] id: ARO:3005962 name: OXA-758 namespace: antibiotic_resistance def: "OXA-758 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-758" EXACT CARD_Short_Name [] [Term] id: ARO:3005963 name: OXA-759 namespace: antibiotic_resistance def: "OXA-759 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-759" EXACT CARD_Short_Name [] [Term] id: ARO:3005964 name: OXA-760 namespace: antibiotic_resistance def: "OXA-760 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-760" EXACT CARD_Short_Name [] [Term] id: ARO:3005965 name: OXA-761 namespace: antibiotic_resistance def: "OXA-761 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-761" EXACT CARD_Short_Name [] [Term] id: ARO:3005966 name: OXA-762 namespace: antibiotic_resistance def: "OXA-762 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-762" EXACT CARD_Short_Name [] [Term] id: ARO:3005967 name: OXA-763 namespace: antibiotic_resistance def: "OXA-763 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-763" EXACT CARD_Short_Name [] [Term] id: ARO:3005968 name: OXA-764 namespace: antibiotic_resistance def: "OXA-764 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-764" EXACT CARD_Short_Name [] [Term] id: ARO:3005969 name: OXA-765 namespace: antibiotic_resistance def: "OXA-765 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-765" EXACT CARD_Short_Name [] [Term] id: ARO:3005970 name: OXA-766 namespace: antibiotic_resistance def: "OXA-766 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-766" EXACT CARD_Short_Name [] [Term] id: ARO:3005971 name: OXA-767 namespace: antibiotic_resistance def: "OXA-767 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-767" EXACT CARD_Short_Name [] [Term] id: ARO:3005972 name: OXA-768 namespace: antibiotic_resistance def: "OXA-768 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-768" EXACT CARD_Short_Name [] [Term] id: ARO:3005973 name: OXA-769 namespace: antibiotic_resistance def: "OXA-769 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-769" EXACT CARD_Short_Name [] [Term] id: ARO:3005974 name: OXA-770 namespace: antibiotic_resistance def: "OXA-770 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-770" EXACT CARD_Short_Name [] [Term] id: ARO:3005975 name: OXA-771 namespace: antibiotic_resistance def: "OXA-771 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-771" EXACT CARD_Short_Name [] [Term] id: ARO:3005976 name: OXA-772 namespace: antibiotic_resistance def: "OXA-772 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-772" EXACT CARD_Short_Name [] [Term] id: ARO:3005977 name: OXA-773 namespace: antibiotic_resistance def: "OXA-773 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-773" EXACT CARD_Short_Name [] [Term] id: ARO:3005978 name: OXA-774 namespace: antibiotic_resistance def: "OXA-774 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-774" EXACT CARD_Short_Name [] [Term] id: ARO:3005979 name: OXA-775 namespace: antibiotic_resistance def: "OXA-775 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-775" EXACT CARD_Short_Name [] [Term] id: ARO:3005980 name: OXA-776 namespace: antibiotic_resistance def: "OXA-776 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-776" EXACT CARD_Short_Name [] [Term] id: ARO:3005981 name: OXA-777 namespace: antibiotic_resistance def: "OXA-777 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-777" EXACT CARD_Short_Name [] [Term] id: ARO:3005982 name: OXA-778 namespace: antibiotic_resistance def: "OXA-778 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-778" EXACT CARD_Short_Name [] [Term] id: ARO:3005983 name: OXA-780 namespace: antibiotic_resistance def: "OXA-780 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-780" EXACT CARD_Short_Name [] [Term] id: ARO:3005984 name: OXA-781 namespace: antibiotic_resistance def: "OXA-781 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-781" EXACT CARD_Short_Name [] [Term] id: ARO:3005985 name: OXA-782 namespace: antibiotic_resistance def: "OXA-782 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-782" EXACT CARD_Short_Name [] [Term] id: ARO:3005986 name: OXA-783 namespace: antibiotic_resistance def: "OXA-783 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-783" EXACT CARD_Short_Name [] [Term] id: ARO:3005987 name: OXA-784 namespace: antibiotic_resistance def: "OXA-784 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-784" EXACT CARD_Short_Name [] [Term] id: ARO:3005988 name: OXA-785 namespace: antibiotic_resistance def: "OXA-785 is a OXA beta-lactamase." [] is_a: ARO:3007702 ! OXA-184-like beta-lactamase synonym: "OXA-785" EXACT CARD_Short_Name [] [Term] id: ARO:3005989 name: OXA-786 namespace: antibiotic_resistance def: "OXA-786 is a OXA beta-lactamase." [] is_a: ARO:3007730 ! OXA-61-like beta-lactamase synonym: "OXA-786" EXACT CARD_Short_Name [] [Term] id: ARO:3005990 name: OXA-787 namespace: antibiotic_resistance def: "OXA-787 is a OXA beta-lactamase." [] is_a: ARO:3007716 ! OXA-364-like beta-lactamase synonym: "OXA-787" EXACT CARD_Short_Name [] [Term] id: ARO:3005991 name: OXA-788 namespace: antibiotic_resistance def: "OXA-788 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-788" EXACT CARD_Short_Name [] [Term] id: ARO:3005992 name: OXA-789 namespace: antibiotic_resistance def: "OXA-789 is a OXA beta-lactamase." [] is_a: ARO:3007716 ! OXA-364-like beta-lactamase synonym: "OXA-789" EXACT CARD_Short_Name [] [Term] id: ARO:3005993 name: OXA-793 namespace: antibiotic_resistance def: "OXA-793 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-793" EXACT CARD_Short_Name [] [Term] id: ARO:3005994 name: OXA-794 namespace: antibiotic_resistance def: "OXA-794 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-794" EXACT CARD_Short_Name [] [Term] id: ARO:3005995 name: OXA-795 namespace: antibiotic_resistance def: "OXA-795 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-795" EXACT CARD_Short_Name [] [Term] id: ARO:3005996 name: OXA-796 namespace: antibiotic_resistance def: "OXA-796 is a OXA beta-lactamase." [] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-796" EXACT CARD_Short_Name [] [Term] id: ARO:3005997 name: OXA-797 namespace: antibiotic_resistance def: "OXA-797 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-797" EXACT CARD_Short_Name [] [Term] id: ARO:3005998 name: OXA-798 namespace: antibiotic_resistance def: "OXA-798 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-798" EXACT CARD_Short_Name [] [Term] id: ARO:3005999 name: OXA-799 namespace: antibiotic_resistance def: "OXA-799 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-799" EXACT CARD_Short_Name [] [Term] id: ARO:3006000 name: OXA-800 namespace: antibiotic_resistance def: "OXA-800 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-800" EXACT CARD_Short_Name [] [Term] id: ARO:3006001 name: OXA-801 namespace: antibiotic_resistance def: "OXA-801 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-801" EXACT CARD_Short_Name [] [Term] id: ARO:3006002 name: OXA-802 namespace: antibiotic_resistance def: "OXA-802 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-802" EXACT CARD_Short_Name [] [Term] id: ARO:3006003 name: OXA-803 namespace: antibiotic_resistance def: "OXA-803 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-803" EXACT CARD_Short_Name [] [Term] id: ARO:3006004 name: OXA-804 namespace: antibiotic_resistance def: "OXA-804 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-804" EXACT CARD_Short_Name [] [Term] id: ARO:3006005 name: OXA-805 namespace: antibiotic_resistance def: "OXA-805 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-805" EXACT CARD_Short_Name [] [Term] id: ARO:3006006 name: OXA-806 namespace: antibiotic_resistance def: "OXA-806 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-806" EXACT CARD_Short_Name [] [Term] id: ARO:3006007 name: OXA-807 namespace: antibiotic_resistance def: "OXA-807 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-807" EXACT CARD_Short_Name [] [Term] id: ARO:3006008 name: OXA-808 namespace: antibiotic_resistance def: "OXA-808 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-808" EXACT CARD_Short_Name [] [Term] id: ARO:3006009 name: OXA-809 namespace: antibiotic_resistance def: "OXA-809 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-809" EXACT CARD_Short_Name [] [Term] id: ARO:3006010 name: OXA-810 namespace: antibiotic_resistance def: "OXA-810 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-810" EXACT CARD_Short_Name [] [Term] id: ARO:3006011 name: OXA-811 namespace: antibiotic_resistance def: "OXA-811 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-811" EXACT CARD_Short_Name [] [Term] id: ARO:3006012 name: OXA-813 namespace: antibiotic_resistance def: "OXA-813 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-813" EXACT CARD_Short_Name [] [Term] id: ARO:3006013 name: OXA-814 namespace: antibiotic_resistance def: "OXA-814 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-814" EXACT CARD_Short_Name [] [Term] id: ARO:3006014 name: OXA-815 namespace: antibiotic_resistance def: "OXA-815 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-815" EXACT CARD_Short_Name [] [Term] id: ARO:3006015 name: OXA-816 namespace: antibiotic_resistance def: "OXA-816 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-816" EXACT CARD_Short_Name [] [Term] id: ARO:3006016 name: OXA-817 namespace: antibiotic_resistance def: "OXA-817 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-817" EXACT CARD_Short_Name [] [Term] id: ARO:3006017 name: OXA-819 namespace: antibiotic_resistance def: "OXA-819 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-819" EXACT CARD_Short_Name [] [Term] id: ARO:3006018 name: OXA-820 namespace: antibiotic_resistance def: "OXA-820 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-820" EXACT CARD_Short_Name [] [Term] id: ARO:3006019 name: OXA-821 namespace: antibiotic_resistance def: "OXA-821 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-821" EXACT CARD_Short_Name [] [Term] id: ARO:3006020 name: OXA-822 namespace: antibiotic_resistance def: "OXA-822 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-822" EXACT CARD_Short_Name [] [Term] id: ARO:3006021 name: OXA-823 namespace: antibiotic_resistance def: "OXA-823 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-823" EXACT CARD_Short_Name [] [Term] id: ARO:3006022 name: OXA-824 namespace: antibiotic_resistance def: "OXA-824 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-824" EXACT CARD_Short_Name [] [Term] id: ARO:3006023 name: OXA-826 namespace: antibiotic_resistance def: "OXA-826 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-826" EXACT CARD_Short_Name [] [Term] id: ARO:3006024 name: OXA-827 namespace: antibiotic_resistance def: "OXA-827 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-827" EXACT CARD_Short_Name [] [Term] id: ARO:3006025 name: OXA-828 namespace: antibiotic_resistance def: "OXA-828 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-828" EXACT CARD_Short_Name [] [Term] id: ARO:3006026 name: OXA-829 namespace: antibiotic_resistance def: "OXA-829 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-829" EXACT CARD_Short_Name [] [Term] id: ARO:3006027 name: OXA-830 namespace: antibiotic_resistance def: "OXA-830 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-830" EXACT CARD_Short_Name [] [Term] id: ARO:3006028 name: OXA-831 namespace: antibiotic_resistance def: "OXA-831 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-831" EXACT CARD_Short_Name [] [Term] id: ARO:3006029 name: OXA-832 namespace: antibiotic_resistance def: "OXA-832 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-832" EXACT CARD_Short_Name [] [Term] id: ARO:3006030 name: OXA-833 namespace: antibiotic_resistance def: "OXA-833 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-833" EXACT CARD_Short_Name [] [Term] id: ARO:3006031 name: OXA-834 namespace: antibiotic_resistance def: "OXA-834 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-834" EXACT CARD_Short_Name [] [Term] id: ARO:3006032 name: OXA-836 namespace: antibiotic_resistance def: "OXA-836 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-836" EXACT CARD_Short_Name [] [Term] id: ARO:3006033 name: OXA-839 namespace: antibiotic_resistance def: "OXA-839 is a OXA beta-lactamase." [] is_a: ARO:3007698 ! OXA-114-like beta-lactamase synonym: "OXA-839" EXACT CARD_Short_Name [] [Term] id: ARO:3006034 name: OXA-840 namespace: antibiotic_resistance def: "OXA-840 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-840" EXACT CARD_Short_Name [] [Term] id: ARO:3006035 name: OXA-841 namespace: antibiotic_resistance def: "OXA-841 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-841" EXACT CARD_Short_Name [] [Term] id: ARO:3006036 name: OXA-842 namespace: antibiotic_resistance def: "OXA-842 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-842" EXACT CARD_Short_Name [] [Term] id: ARO:3006037 name: OXA-843 namespace: antibiotic_resistance def: "OXA-843 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-843" EXACT CARD_Short_Name [] [Term] id: ARO:3006038 name: OXA-844 namespace: antibiotic_resistance def: "OXA-844 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-844" EXACT CARD_Short_Name [] [Term] id: ARO:3006039 name: OXA-845 namespace: antibiotic_resistance def: "OXA-845 is a OXA beta-lactamase." [] is_a: ARO:3007707 ! OXA-214-like beta-lactamase synonym: "OXA-845" EXACT CARD_Short_Name [] [Term] id: ARO:3006040 name: OXA-847 namespace: antibiotic_resistance def: "OXA-847 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-847" EXACT CARD_Short_Name [] [Term] id: ARO:3006041 name: OXA-848 namespace: antibiotic_resistance def: "OXA-848 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-848" EXACT CARD_Short_Name [] [Term] id: ARO:3006042 name: OXA-849 namespace: antibiotic_resistance def: "OXA-849 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-849" EXACT CARD_Short_Name [] [Term] id: ARO:3006043 name: OXA-851 namespace: antibiotic_resistance def: "OXA-851 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-851" EXACT CARD_Short_Name [] [Term] id: ARO:3006044 name: OXA-852 namespace: antibiotic_resistance def: "OXA-852 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-852" EXACT CARD_Short_Name [] [Term] id: ARO:3006045 name: OXA-853 namespace: antibiotic_resistance def: "OXA-853 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-853" EXACT CARD_Short_Name [] [Term] id: ARO:3006046 name: OXA-854 namespace: antibiotic_resistance def: "OXA-854 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-854" EXACT CARD_Short_Name [] [Term] id: ARO:3006047 name: OXA-855 namespace: antibiotic_resistance def: "OXA-855 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-855" EXACT CARD_Short_Name [] [Term] id: ARO:3006048 name: OXA-856 namespace: antibiotic_resistance def: "OXA-856 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-856" EXACT CARD_Short_Name [] [Term] id: ARO:3006049 name: OXA-857 namespace: antibiotic_resistance def: "OXA-857 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-857" EXACT CARD_Short_Name [] [Term] id: ARO:3006050 name: OXA-858 namespace: antibiotic_resistance def: "OXA-858 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-858" EXACT CARD_Short_Name [] [Term] id: ARO:3006051 name: OXA-859 namespace: antibiotic_resistance def: "OXA-859 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-859" EXACT CARD_Short_Name [] [Term] id: ARO:3006052 name: OXA-860 namespace: antibiotic_resistance def: "OXA-860 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-860" EXACT CARD_Short_Name [] [Term] id: ARO:3006053 name: OXA-861 namespace: antibiotic_resistance def: "OXA-861 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-861" EXACT CARD_Short_Name [] [Term] id: ARO:3006054 name: OXA-862 namespace: antibiotic_resistance def: "OXA-862 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-862" EXACT CARD_Short_Name [] [Term] id: ARO:3006055 name: OXA-863 namespace: antibiotic_resistance def: "OXA-863 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-863" EXACT CARD_Short_Name [] [Term] id: ARO:3006056 name: OXA-864 namespace: antibiotic_resistance def: "OXA-864 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-864" EXACT CARD_Short_Name [] [Term] id: ARO:3006057 name: OXA-865 namespace: antibiotic_resistance def: "OXA-865 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-865" EXACT CARD_Short_Name [] [Term] id: ARO:3006058 name: OXA-866 namespace: antibiotic_resistance def: "OXA-866 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-866" EXACT CARD_Short_Name [] [Term] id: ARO:3006059 name: OXA-867 namespace: antibiotic_resistance def: "OXA-867 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-867" EXACT CARD_Short_Name [] [Term] id: ARO:3006060 name: OXA-868 namespace: antibiotic_resistance def: "OXA-868 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-868" EXACT CARD_Short_Name [] [Term] id: ARO:3006061 name: OXA-869 namespace: antibiotic_resistance def: "OXA-869 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-869" EXACT CARD_Short_Name [] [Term] id: ARO:3006062 name: OXA-870 namespace: antibiotic_resistance def: "OXA-870 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-870" EXACT CARD_Short_Name [] [Term] id: ARO:3006063 name: OXA-871 namespace: antibiotic_resistance def: "OXA-871 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-871" EXACT CARD_Short_Name [] [Term] id: ARO:3006064 name: OXA-872 namespace: antibiotic_resistance def: "OXA-872 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-872" EXACT CARD_Short_Name [] [Term] id: ARO:3006065 name: OXA-873 namespace: antibiotic_resistance def: "OXA-873 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-873" EXACT CARD_Short_Name [] [Term] id: ARO:3006066 name: OXA-874 namespace: antibiotic_resistance def: "OXA-874 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-874" EXACT CARD_Short_Name [] [Term] id: ARO:3006067 name: OXA-875 namespace: antibiotic_resistance def: "OXA-875 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-875" EXACT CARD_Short_Name [] [Term] id: ARO:3006068 name: OXA-876 namespace: antibiotic_resistance def: "OXA-876 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-876" EXACT CARD_Short_Name [] [Term] id: ARO:3006069 name: OXA-877 namespace: antibiotic_resistance def: "OXA-877 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-877" EXACT CARD_Short_Name [] [Term] id: ARO:3006070 name: OXA-878 namespace: antibiotic_resistance def: "OXA-878 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-878" EXACT CARD_Short_Name [] [Term] id: ARO:3006071 name: OXA-879 namespace: antibiotic_resistance def: "OXA-879 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-879" EXACT CARD_Short_Name [] [Term] id: ARO:3006072 name: OXA-880 namespace: antibiotic_resistance def: "OXA-880 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-880" EXACT CARD_Short_Name [] [Term] id: ARO:3006073 name: OXA-881 namespace: antibiotic_resistance def: "OXA-881 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-881" EXACT CARD_Short_Name [] [Term] id: ARO:3006074 name: OXA-882 namespace: antibiotic_resistance def: "OXA-882 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-882" EXACT CARD_Short_Name [] [Term] id: ARO:3006075 name: OXA-883 namespace: antibiotic_resistance def: "OXA-883 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-883" EXACT CARD_Short_Name [] [Term] id: ARO:3006076 name: OXA-884 namespace: antibiotic_resistance def: "OXA-884 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-884" EXACT CARD_Short_Name [] [Term] id: ARO:3006077 name: OXA-885 namespace: antibiotic_resistance def: "OXA-885 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-885" EXACT CARD_Short_Name [] [Term] id: ARO:3006078 name: OXA-886 namespace: antibiotic_resistance def: "OXA-886 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-886" EXACT CARD_Short_Name [] [Term] id: ARO:3006079 name: OXA-887 namespace: antibiotic_resistance def: "OXA-887 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-887" EXACT CARD_Short_Name [] [Term] id: ARO:3006080 name: OXA-888 namespace: antibiotic_resistance def: "OXA-888 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-888" EXACT CARD_Short_Name [] [Term] id: ARO:3006081 name: OXA-889 namespace: antibiotic_resistance def: "OXA-889 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-889" EXACT CARD_Short_Name [] [Term] id: ARO:3006082 name: OXA-890 namespace: antibiotic_resistance def: "OXA-890 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-890" EXACT CARD_Short_Name [] [Term] id: ARO:3006083 name: OXA-891 namespace: antibiotic_resistance def: "OXA-891 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-891" EXACT CARD_Short_Name [] [Term] id: ARO:3006084 name: OXA-892 namespace: antibiotic_resistance def: "OXA-892 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-892" EXACT CARD_Short_Name [] [Term] id: ARO:3006085 name: OXA-893 namespace: antibiotic_resistance def: "OXA-893 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-893" EXACT CARD_Short_Name [] [Term] id: ARO:3006086 name: OXA-894 namespace: antibiotic_resistance def: "OXA-894 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-894" EXACT CARD_Short_Name [] [Term] id: ARO:3006087 name: OXA-896 namespace: antibiotic_resistance def: "OXA-896 is a OXA beta-lactamase." [] is_a: ARO:3007735 ! OXA-9-like beta-lactamase synonym: "OXA-896" EXACT CARD_Short_Name [] [Term] id: ARO:3006088 name: OXA-900 namespace: antibiotic_resistance def: "OXA-900 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-900" EXACT CARD_Short_Name [] [Term] id: ARO:3006089 name: OXA-901 namespace: antibiotic_resistance def: "OXA-901 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-901" EXACT CARD_Short_Name [] [Term] id: ARO:3006090 name: OXA-902 namespace: antibiotic_resistance def: "OXA-902 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-902" EXACT CARD_Short_Name [] [Term] id: ARO:3006091 name: OXA-903 namespace: antibiotic_resistance def: "OXA-903 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-903" EXACT CARD_Short_Name [] [Term] id: ARO:3006092 name: OXA-904 namespace: antibiotic_resistance def: "OXA-904 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-904" EXACT CARD_Short_Name [] [Term] id: ARO:3006093 name: OXA-905 namespace: antibiotic_resistance def: "OXA-905 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-905" EXACT CARD_Short_Name [] [Term] id: ARO:3006094 name: OXA-907 namespace: antibiotic_resistance def: "OXA-907 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-907" EXACT CARD_Short_Name [] [Term] id: ARO:3006095 name: OXA-908 namespace: antibiotic_resistance def: "OXA-908 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-908" EXACT CARD_Short_Name [] [Term] id: ARO:3006096 name: OXA-909 namespace: antibiotic_resistance def: "OXA-909 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-909" EXACT CARD_Short_Name [] [Term] id: ARO:3006097 name: OXA-910 namespace: antibiotic_resistance def: "OXA-910 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-910" EXACT CARD_Short_Name [] [Term] id: ARO:3006098 name: OXA-911 namespace: antibiotic_resistance def: "OXA-911 is a OXA beta-lactamase." [] is_a: ARO:3007710 ! OXA-23-like beta-lactamase synonym: "OXA-911" EXACT CARD_Short_Name [] [Term] id: ARO:3006099 name: OXA-912 namespace: antibiotic_resistance def: "OXA-912 is a OXA beta-lactamase." [] is_a: ARO:3007699 ! OXA-12-like beta-lactamase synonym: "OXA-912" EXACT CARD_Short_Name [] [Term] id: ARO:3006100 name: OXA-913 namespace: antibiotic_resistance def: "OXA-913 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-913" EXACT CARD_Short_Name [] [Term] id: ARO:3006101 name: OXA-914 namespace: antibiotic_resistance def: "OXA-914 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-914" EXACT CARD_Short_Name [] [Term] id: ARO:3006102 name: OXA-916 namespace: antibiotic_resistance def: "OXA-916 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-916" EXACT CARD_Short_Name [] [Term] id: ARO:3006103 name: OXA-917 namespace: antibiotic_resistance def: "OXA-917 is a OXA beta-lactamase." [] is_a: ARO:3007719 ! OXA-427-like beta-lactamase synonym: "OXA-917" EXACT CARD_Short_Name [] [Term] id: ARO:3006104 name: OXA-918 namespace: antibiotic_resistance def: "OXA-918 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-918" EXACT CARD_Short_Name [] [Term] id: ARO:3006105 name: OXA-919 namespace: antibiotic_resistance def: "OXA-919 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-919" EXACT CARD_Short_Name [] [Term] id: ARO:3006106 name: OXA-920 namespace: antibiotic_resistance def: "OXA-920 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-920" EXACT CARD_Short_Name [] [Term] id: ARO:3006107 name: OXA-921 namespace: antibiotic_resistance def: "OXA-921 is a OXA beta-lactamase." [] is_a: ARO:3007696 ! OXA-1-like beta-lactamase synonym: "OXA-921" EXACT CARD_Short_Name [] [Term] id: ARO:3006108 name: OXA-922 namespace: antibiotic_resistance def: "OXA-922 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-922" EXACT CARD_Short_Name [] [Term] id: ARO:3006109 name: OXA-923 namespace: antibiotic_resistance def: "OXA-923 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-923" EXACT CARD_Short_Name [] [Term] id: ARO:3006110 name: OXA-924 namespace: antibiotic_resistance def: "OXA-924 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-924" EXACT CARD_Short_Name [] [Term] id: ARO:3006111 name: OXA-925 namespace: antibiotic_resistance def: "OXA-925 is a OXA beta-lactamase." [] is_a: ARO:3000017 ! OXA beta-lactamase synonym: "OXA-925" EXACT CARD_Short_Name [] [Term] id: ARO:3006112 name: OXA-927 namespace: antibiotic_resistance def: "OXA-927 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-927" EXACT CARD_Short_Name [] [Term] id: ARO:3006113 name: OXA-928 namespace: antibiotic_resistance def: "OXA-928 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-928" EXACT CARD_Short_Name [] [Term] id: ARO:3006114 name: OXA-929 namespace: antibiotic_resistance def: "OXA-929 is a OXA beta-lactamase." [] is_a: ARO:3007721 ! OXA-48-like beta-lactamase synonym: "OXA-929" EXACT CARD_Short_Name [] [Term] id: ARO:3006115 name: OXA-932 namespace: antibiotic_resistance def: "OXA-932 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-932" EXACT CARD_Short_Name [] [Term] id: ARO:3006116 name: OXA-935 namespace: antibiotic_resistance def: "OXA-935 is a OXA beta-lactamase." [] is_a: ARO:3007697 ! OXA-10-like beta-lactamase synonym: "OXA-935" EXACT CARD_Short_Name [] [Term] id: ARO:3006117 name: OXA-937 namespace: antibiotic_resistance def: "OXA-937 is a OXA beta-lactamase." [] is_a: ARO:3007724 ! OXA-50-like beta-lactamase synonym: "OXA-937" EXACT CARD_Short_Name [] [Term] id: ARO:3006118 name: OXA-938 namespace: antibiotic_resistance def: "OXA-938 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-938" EXACT CARD_Short_Name [] [Term] id: ARO:3006119 name: OXA-939 namespace: antibiotic_resistance def: "OXA-939 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-939" EXACT CARD_Short_Name [] [Term] id: ARO:3006120 name: OXA-940 namespace: antibiotic_resistance def: "OXA-940 is a OXA beta-lactamase." [] is_a: ARO:3007725 ! OXA-51-like beta-lactamase synonym: "OXA-940" EXACT CARD_Short_Name [] [Term] id: ARO:3006121 name: OXA-941 namespace: antibiotic_resistance def: "OXA-941 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-941" EXACT CARD_Short_Name [] [Term] id: ARO:3006122 name: OXA-942 namespace: antibiotic_resistance def: "OXA-942 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-942" EXACT CARD_Short_Name [] [Term] id: ARO:3006123 name: OXA-943 namespace: antibiotic_resistance def: "OXA-943 is a OXA beta-lactamase." [] is_a: ARO:3007706 ! OXA-213-like beta-lactamase synonym: "OXA-943" EXACT CARD_Short_Name [] [Term] id: ARO:3006124 name: OXA-945 namespace: antibiotic_resistance def: "OXA-945 is a OXA beta-lactamase." [] is_a: ARO:3007701 ! OXA-143-like beta-lactamase synonym: "OXA-945" EXACT CARD_Short_Name [] [Term] id: ARO:3006125 name: OXA-946 namespace: antibiotic_resistance def: "OXA-946 is a OXA beta-lactamase." [] is_a: ARO:3007733 ! OXA-679-like beta-lactamase synonym: "OXA-946" EXACT CARD_Short_Name [] [Term] id: ARO:3006126 name: OXA-947 namespace: antibiotic_resistance def: "OXA-947 is a OXA beta-lactamase." [] is_a: ARO:3007733 ! OXA-679-like beta-lactamase synonym: "OXA-947" EXACT CARD_Short_Name [] [Term] id: ARO:3006127 name: OXA-948 namespace: antibiotic_resistance def: "OXA-948 is a OXA beta-lactamase." [] is_a: ARO:3007733 ! OXA-679-like beta-lactamase synonym: "OXA-948" EXACT CARD_Short_Name [] [Term] id: ARO:3006128 name: OXA-949 namespace: antibiotic_resistance def: "OXA-949 is a OXA beta-lactamase." [] is_a: ARO:3007733 ! OXA-679-like beta-lactamase synonym: "OXA-949" EXACT CARD_Short_Name [] [Term] id: ARO:3006129 name: OXY-2-14 namespace: antibiotic_resistance def: "OXY-2-14 is a OXY beta-lactamase." [] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-14" EXACT CARD_Short_Name [] [Term] id: ARO:3006130 name: OXY-2-15 namespace: antibiotic_resistance def: "OXY-2-15 is a OXY beta-lactamase." [] is_a: ARO:3002388 ! OXY beta-lactamase synonym: "OXY-2-15" EXACT CARD_Short_Name [] [Term] id: ARO:3006131 name: PER-10 namespace: antibiotic_resistance def: "PER-10 is a PER beta-lactamase." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-10" EXACT CARD_Short_Name [] [Term] id: ARO:3006132 name: PER-11 namespace: antibiotic_resistance def: "PER-11 is a PER beta-lactamase." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-11" EXACT CARD_Short_Name [] [Term] id: ARO:3006133 name: PER-12 namespace: antibiotic_resistance def: "PER-12 is a PER beta-lactamase." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-12" EXACT CARD_Short_Name [] [Term] id: ARO:3006134 name: PER-13 namespace: antibiotic_resistance def: "PER-13 is a PER beta-lactamase." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-13" EXACT CARD_Short_Name [] [Term] id: ARO:3006135 name: PER-14 namespace: antibiotic_resistance def: "PER-14 is a PER beta-lactamase." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-14" EXACT CARD_Short_Name [] [Term] id: ARO:3006136 name: PER-15 namespace: antibiotic_resistance def: "PER-15 is a PER beta-lactamase." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-15" EXACT CARD_Short_Name [] [Term] id: ARO:3006137 name: PER-16 namespace: antibiotic_resistance def: "PER-16 is a PER beta-lactamase." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-16" EXACT CARD_Short_Name [] [Term] id: ARO:3006138 name: PER-9 namespace: antibiotic_resistance def: "PER-9 is a PER beta-lactamase." [] is_a: ARO:3000056 ! PER beta-lactamase synonym: "PER-9" EXACT CARD_Short_Name [] [Term] id: ARO:3006139 name: TEM-98 namespace: antibiotic_resistance def: "TEM-98 is a TEM beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-98" EXACT CARD_Short_Name [] [Term] id: ARO:3006140 name: TEM-99 namespace: antibiotic_resistance def: "TEM-99 is a TEM beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-99" EXACT CARD_Short_Name [] [Term] id: ARO:3006141 name: OKP-A-17 namespace: antibiotic_resistance def: "OKP-A-17 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-A-17" EXACT CARD_Short_Name [] [Term] id: ARO:3006142 name: OKP-B-16 namespace: antibiotic_resistance def: "OKP-B-16 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-16" EXACT CARD_Short_Name [] [Term] id: ARO:3006143 name: OKP-B-21 namespace: antibiotic_resistance def: "OKP-B-21 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-21" EXACT CARD_Short_Name [] [Term] id: ARO:3006144 name: OKP-B-22 namespace: antibiotic_resistance def: "OKP-B-22 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-22" EXACT CARD_Short_Name [] [Term] id: ARO:3006145 name: OKP-B-23 namespace: antibiotic_resistance def: "OKP-B-23 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-23" EXACT CARD_Short_Name [] [Term] id: ARO:3006146 name: OKP-B-24 namespace: antibiotic_resistance def: "OKP-B-24 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-24" EXACT CARD_Short_Name [] [Term] id: ARO:3006147 name: OKP-B-34 namespace: antibiotic_resistance def: "OKP-B-34 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-34" EXACT CARD_Short_Name [] [Term] id: ARO:3006148 name: OKP-B-36 namespace: antibiotic_resistance def: "OKP-B-36 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-36" EXACT CARD_Short_Name [] [Term] id: ARO:3006149 name: OKP-B-40 namespace: antibiotic_resistance def: "OKP-B-40 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-40" EXACT CARD_Short_Name [] [Term] id: ARO:3006150 name: OKP-B-41 namespace: antibiotic_resistance def: "OKP-B-41 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-41" EXACT CARD_Short_Name [] [Term] id: ARO:3006151 name: OKP-B-45 namespace: antibiotic_resistance def: "OKP-B-45 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-B-45" EXACT CARD_Short_Name [] [Term] id: ARO:3006152 name: OKP-C-1 namespace: antibiotic_resistance def: "OKP-C-1 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-C-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006153 name: OKP-D-1 namespace: antibiotic_resistance def: "OKP-D-1 is a OKP beta-lactamase." [] is_a: ARO:3002417 ! OKP beta-lactamase synonym: "OKP-D-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006154 name: BEL-4 namespace: antibiotic_resistance def: "BEL-4 is a BEL beta-lactamase." [] is_a: ARO:3002384 ! BEL beta-lactamase synonym: "BEL-4" EXACT CARD_Short_Name [] [Term] id: ARO:3006155 name: CME-2 namespace: antibiotic_resistance def: "CME-2 is a CME beta-lactamase." [] is_a: ARO:3004774 ! CME beta-lactamase synonym: "CME-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006156 name: GES-27 namespace: antibiotic_resistance def: "GES-27 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-27" EXACT CARD_Short_Name [] [Term] id: ARO:3006157 name: GES-28 namespace: antibiotic_resistance def: "GES-28 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-28" EXACT CARD_Short_Name [] [Term] id: ARO:3006158 name: GES-29 namespace: antibiotic_resistance def: "GES-29 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-29" EXACT CARD_Short_Name [] [Term] id: ARO:3006159 name: GES-30 namespace: antibiotic_resistance def: "GES-30 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-30" EXACT CARD_Short_Name [] [Term] id: ARO:3006160 name: GES-31 namespace: antibiotic_resistance def: "GES-31 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-31" EXACT CARD_Short_Name [] [Term] id: ARO:3006161 name: GES-32 namespace: antibiotic_resistance def: "GES-32 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-32" EXACT CARD_Short_Name [] [Term] id: ARO:3006162 name: GES-33 namespace: antibiotic_resistance def: "GES-33 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-33" EXACT CARD_Short_Name [] [Term] id: ARO:3006163 name: GES-34 namespace: antibiotic_resistance def: "GES-34 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-34" EXACT CARD_Short_Name [] [Term] id: ARO:3006164 name: GES-35 namespace: antibiotic_resistance def: "GES-35 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-35" EXACT CARD_Short_Name [] [Term] id: ARO:3006165 name: GES-36 namespace: antibiotic_resistance def: "GES-36 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-36" EXACT CARD_Short_Name [] [Term] id: ARO:3006166 name: GES-37 namespace: antibiotic_resistance def: "GES-37 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-37" EXACT CARD_Short_Name [] [Term] id: ARO:3006167 name: GES-38 namespace: antibiotic_resistance def: "GES-38 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-38" EXACT CARD_Short_Name [] [Term] id: ARO:3006168 name: GES-39 namespace: antibiotic_resistance def: "GES-39 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-39" EXACT CARD_Short_Name [] [Term] id: ARO:3006169 name: GES-40 namespace: antibiotic_resistance def: "GES-40 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-40" EXACT CARD_Short_Name [] [Term] id: ARO:3006170 name: GES-41 namespace: antibiotic_resistance def: "GES-41 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-41" EXACT CARD_Short_Name [] [Term] id: ARO:3006171 name: GES-42 namespace: antibiotic_resistance def: "GES-42 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-42" EXACT CARD_Short_Name [] [Term] id: ARO:3006172 name: GES-43 namespace: antibiotic_resistance def: "GES-43 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-43" EXACT CARD_Short_Name [] [Term] id: ARO:3006173 name: GES-44 namespace: antibiotic_resistance def: "GES-44 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-44" EXACT CARD_Short_Name [] [Term] id: ARO:3006174 name: GES-45 namespace: antibiotic_resistance def: "GES-45 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-45" EXACT CARD_Short_Name [] [Term] id: ARO:3006175 name: GES-46 namespace: antibiotic_resistance def: "GES-46 is a GES beta-lactamase." [] is_a: ARO:3000066 ! GES beta-lactamase synonym: "GES-46" EXACT CARD_Short_Name [] [Term] id: ARO:3006176 name: IMI-12 namespace: antibiotic_resistance def: "IMI-12 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-12" EXACT CARD_Short_Name [] [Term] id: ARO:3006177 name: IMI-13 namespace: antibiotic_resistance def: "IMI-13 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-13" EXACT CARD_Short_Name [] [Term] id: ARO:3006178 name: IMI-14 namespace: antibiotic_resistance def: "IMI-14 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-14" EXACT CARD_Short_Name [] [Term] id: ARO:3006179 name: IMI-15 namespace: antibiotic_resistance def: "IMI-15 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-15" EXACT CARD_Short_Name [] [Term] id: ARO:3006180 name: IMI-16 namespace: antibiotic_resistance def: "IMI-16 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-16" EXACT CARD_Short_Name [] [Term] id: ARO:3006181 name: IMI-17 namespace: antibiotic_resistance def: "IMI-17 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-17" EXACT CARD_Short_Name [] [Term] id: ARO:3006182 name: IMI-18 namespace: antibiotic_resistance def: "IMI-18 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-18" EXACT CARD_Short_Name [] [Term] id: ARO:3006183 name: IMI-19 namespace: antibiotic_resistance def: "IMI-19 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-19" EXACT CARD_Short_Name [] [Term] id: ARO:3006184 name: IMI-20 namespace: antibiotic_resistance def: "IMI-20 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-20" EXACT CARD_Short_Name [] [Term] id: ARO:3006185 name: IMI-21 namespace: antibiotic_resistance def: "IMI-21 is a IMI beta-lactamase." [] is_a: ARO:3000018 ! IMI beta-lactamase synonym: "IMI-21" EXACT CARD_Short_Name [] [Term] id: ARO:3006186 name: KPC-44 namespace: antibiotic_resistance def: "KPC-44 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-44" EXACT CARD_Short_Name [] [Term] id: ARO:3006187 name: KPC-58 namespace: antibiotic_resistance def: "KPC-58 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-58" EXACT CARD_Short_Name [] [Term] id: ARO:3006188 name: KPC-59 namespace: antibiotic_resistance def: "KPC-59 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-59" EXACT CARD_Short_Name [] [Term] id: ARO:3006189 name: KPC-60 namespace: antibiotic_resistance def: "KPC-60 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-60" EXACT CARD_Short_Name [] [Term] id: ARO:3006190 name: KPC-61 namespace: antibiotic_resistance def: "KPC-61 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-61" EXACT CARD_Short_Name [] [Term] id: ARO:3006191 name: KPC-62 namespace: antibiotic_resistance def: "KPC-62 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-62" EXACT CARD_Short_Name [] [Term] id: ARO:3006192 name: KPC-63 namespace: antibiotic_resistance def: "KPC-63 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-63" EXACT CARD_Short_Name [] [Term] id: ARO:3006193 name: KPC-64 namespace: antibiotic_resistance def: "KPC-64 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-64" EXACT CARD_Short_Name [] [Term] id: ARO:3006194 name: KPC-65 namespace: antibiotic_resistance def: "KPC-65 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-65" EXACT CARD_Short_Name [] [Term] id: ARO:3006195 name: KPC-66 namespace: antibiotic_resistance def: "KPC-66 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-66" EXACT CARD_Short_Name [] [Term] id: ARO:3006196 name: KPC-71 namespace: antibiotic_resistance def: "KPC-71 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-71" EXACT CARD_Short_Name [] [Term] id: ARO:3006197 name: KPC-72 namespace: antibiotic_resistance def: "KPC-72 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-72" EXACT CARD_Short_Name [] [Term] id: ARO:3006198 name: KPC-73 namespace: antibiotic_resistance def: "KPC-73 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-73" EXACT CARD_Short_Name [] [Term] id: ARO:3006199 name: KPC-74 namespace: antibiotic_resistance def: "KPC-74 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-74" EXACT CARD_Short_Name [] [Term] id: ARO:3006200 name: KPC-75 namespace: antibiotic_resistance def: "KPC-75 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-75" EXACT CARD_Short_Name [] [Term] id: ARO:3006201 name: KPC-76 namespace: antibiotic_resistance def: "KPC-76 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-76" EXACT CARD_Short_Name [] [Term] id: ARO:3006202 name: KPC-77 namespace: antibiotic_resistance def: "KPC-77 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-77" EXACT CARD_Short_Name [] [Term] id: ARO:3006203 name: KPC-78 namespace: antibiotic_resistance def: "KPC-78 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-78" EXACT CARD_Short_Name [] [Term] id: ARO:3006204 name: KPC-79 namespace: antibiotic_resistance def: "KPC-79 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-79" EXACT CARD_Short_Name [] [Term] id: ARO:3006205 name: KPC-80 namespace: antibiotic_resistance def: "KPC-80 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-80" EXACT CARD_Short_Name [] [Term] id: ARO:3006206 name: KPC-81 namespace: antibiotic_resistance def: "KPC-81 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-81" EXACT CARD_Short_Name [] [Term] id: ARO:3006207 name: KPC-82 namespace: antibiotic_resistance def: "KPC-82 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-82" EXACT CARD_Short_Name [] [Term] id: ARO:3006208 name: VEB-11 namespace: antibiotic_resistance def: "VEB-11 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-11" EXACT CARD_Short_Name [] [Term] id: ARO:3006209 name: VEB-12 namespace: antibiotic_resistance def: "VEB-12 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-12" EXACT CARD_Short_Name [] [Term] id: ARO:3006210 name: VEB-13 namespace: antibiotic_resistance def: "VEB-13 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-13" EXACT CARD_Short_Name [] [Term] id: ARO:3006211 name: VEB-14 namespace: antibiotic_resistance def: "VEB-14 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-14" EXACT CARD_Short_Name [] [Term] id: ARO:3006212 name: VEB-15 namespace: antibiotic_resistance def: "VEB-15 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-15" EXACT CARD_Short_Name [] [Term] id: ARO:3006213 name: VEB-17 namespace: antibiotic_resistance def: "VEB-17 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-17" EXACT CARD_Short_Name [] [Term] id: ARO:3006214 name: VEB-19 namespace: antibiotic_resistance def: "VEB-19 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-19" EXACT CARD_Short_Name [] [Term] id: ARO:3006215 name: VEB-20 namespace: antibiotic_resistance def: "VEB-20 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-20" EXACT CARD_Short_Name [] [Term] id: ARO:3006216 name: VEB-21 namespace: antibiotic_resistance def: "VEB-21 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-21" EXACT CARD_Short_Name [] [Term] id: ARO:3006217 name: VEB-22 namespace: antibiotic_resistance def: "VEB-22 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-22" EXACT CARD_Short_Name [] [Term] id: ARO:3006218 name: VEB-23 namespace: antibiotic_resistance def: "VEB-23 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-23" EXACT CARD_Short_Name [] [Term] id: ARO:3006219 name: VEB-24 namespace: antibiotic_resistance def: "VEB-24 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-24" EXACT CARD_Short_Name [] [Term] id: ARO:3006220 name: VEB-25 namespace: antibiotic_resistance def: "VEB-25 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-25" EXACT CARD_Short_Name [] [Term] id: ARO:3006221 name: VEB-26 namespace: antibiotic_resistance def: "VEB-26 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-26" EXACT CARD_Short_Name [] [Term] id: ARO:3006222 name: VEB-27 namespace: antibiotic_resistance def: "VEB-27 is a VEB beta-lactamase." [] is_a: ARO:3000043 ! VEB beta-lactamase synonym: "VEB-27" EXACT CARD_Short_Name [] [Term] id: ARO:3006223 name: BKC-2 namespace: antibiotic_resistance def: "BKC-2 is a BKC beta-lactamase." [] is_a: ARO:3004756 ! BKC Beta-lactamase synonym: "BKC-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006224 name: CepA-29 namespace: antibiotic_resistance def: "CepA-29 is a CepA beta-lactamase." [] is_a: ARO:3004192 ! CepA beta-lactamase synonym: "CepA-29" EXACT CARD_Short_Name [] [Term] id: ARO:3006225 name: CepA-44 namespace: antibiotic_resistance def: "CepA-44 is a CepA beta-lactamase." [] is_a: ARO:3004192 ! CepA beta-lactamase synonym: "CepA-44" EXACT CARD_Short_Name [] [Term] id: ARO:3006226 name: CepA-49 namespace: antibiotic_resistance def: "CepA-49 is a CepA beta-lactamase." [] is_a: ARO:3004192 ! CepA beta-lactamase synonym: "CepA-49" EXACT CARD_Short_Name [] [Term] id: ARO:3006227 name: FRI-10 namespace: antibiotic_resistance def: "FRI-10 is a FRI beta-lactamase." [] is_a: ARO:3004796 ! FRI beta-lactamase synonym: "FRI-10" EXACT CARD_Short_Name [] [Term] id: ARO:3006228 name: ACC-1a namespace: antibiotic_resistance def: "ACC-1a is a ACC beta-lactamase." [] is_a: ARO:3001815 ! ACC-1 relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "ACC-1a" EXACT CARD_Short_Name [] [Term] id: ARO:3006229 name: ACC-1b namespace: antibiotic_resistance def: "ACC-1b is a ACC beta-lactamase." [] is_a: ARO:3001815 ! ACC-1 relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "ACC-1b" EXACT CARD_Short_Name [] [Term] id: ARO:3006230 name: ACC-1c namespace: antibiotic_resistance def: "ACC-1c is a ACC beta-lactamase." [] is_a: ARO:3001815 ! ACC-1 relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "ACC-1c" EXACT CARD_Short_Name [] [Term] id: ARO:3006231 name: ACC-1d namespace: antibiotic_resistance def: "ACC-1d is a ACC beta-lactamase." [] is_a: ARO:3001815 ! ACC-1 relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "ACC-1d" EXACT CARD_Short_Name [] [Term] id: ARO:3006232 name: ACC-7 namespace: antibiotic_resistance def: "ACC-7 is a ACC beta-lactamase." [] is_a: ARO:3000073 ! ACC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "ACC-7" EXACT CARD_Short_Name [] [Term] id: ARO:3006233 name: ACC-8 namespace: antibiotic_resistance def: "ACC-8 is a ACC beta-lactamase." [] is_a: ARO:3000073 ! ACC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "ACC-8" EXACT CARD_Short_Name [] [Term] id: ARO:3006234 name: ACT-39 namespace: antibiotic_resistance def: "ACT-39 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-39" EXACT CARD_Short_Name [] [Term] id: ARO:3006235 name: ACT-40 namespace: antibiotic_resistance def: "ACT-40 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-40" EXACT CARD_Short_Name [] [Term] id: ARO:3006236 name: ACT-41 namespace: antibiotic_resistance def: "ACT-41 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-41" EXACT CARD_Short_Name [] [Term] id: ARO:3006237 name: ACT-42 namespace: antibiotic_resistance def: "ACT-42 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-42" EXACT CARD_Short_Name [] [Term] id: ARO:3006238 name: ACT-43 namespace: antibiotic_resistance def: "ACT-43 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-43" EXACT CARD_Short_Name [] [Term] id: ARO:3006239 name: ACT-44 namespace: antibiotic_resistance def: "ACT-44 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-44" EXACT CARD_Short_Name [] [Term] id: ARO:3006240 name: ACT-45 namespace: antibiotic_resistance def: "ACT-45 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-45" EXACT CARD_Short_Name [] [Term] id: ARO:3006241 name: ACT-46 namespace: antibiotic_resistance def: "ACT-46 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-46" EXACT CARD_Short_Name [] [Term] id: ARO:3006242 name: ACT-47 namespace: antibiotic_resistance def: "ACT-47 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-47" EXACT CARD_Short_Name [] [Term] id: ARO:3006243 name: ACT-48 namespace: antibiotic_resistance def: "ACT-48 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-48" EXACT CARD_Short_Name [] [Term] id: ARO:3006244 name: ACT-49 namespace: antibiotic_resistance def: "ACT-49 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-49" EXACT CARD_Short_Name [] [Term] id: ARO:3006245 name: ACT-50 namespace: antibiotic_resistance def: "ACT-50 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-50" EXACT CARD_Short_Name [] [Term] id: ARO:3006246 name: ACT-51 namespace: antibiotic_resistance def: "ACT-51 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-51" EXACT CARD_Short_Name [] [Term] id: ARO:3006247 name: ACT-52 namespace: antibiotic_resistance def: "ACT-52 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-52" EXACT CARD_Short_Name [] [Term] id: ARO:3006248 name: ACT-53 namespace: antibiotic_resistance def: "ACT-53 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-53" EXACT CARD_Short_Name [] [Term] id: ARO:3006249 name: ACT-54 namespace: antibiotic_resistance def: "ACT-54 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-54" EXACT CARD_Short_Name [] [Term] id: ARO:3006250 name: ACT-55 namespace: antibiotic_resistance def: "ACT-55 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-55" EXACT CARD_Short_Name [] [Term] id: ARO:3006251 name: ACT-56 namespace: antibiotic_resistance def: "ACT-56 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-56" EXACT CARD_Short_Name [] [Term] id: ARO:3006252 name: ACT-57 namespace: antibiotic_resistance def: "ACT-57 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-57" EXACT CARD_Short_Name [] [Term] id: ARO:3006253 name: ACT-58 namespace: antibiotic_resistance def: "ACT-58 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-58" EXACT CARD_Short_Name [] [Term] id: ARO:3006254 name: ACT-59 namespace: antibiotic_resistance def: "ACT-59 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-59" EXACT CARD_Short_Name [] [Term] id: ARO:3006255 name: ACT-60 namespace: antibiotic_resistance def: "ACT-60 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-60" EXACT CARD_Short_Name [] [Term] id: ARO:3006256 name: ACT-61 namespace: antibiotic_resistance def: "ACT-61 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-61" EXACT CARD_Short_Name [] [Term] id: ARO:3006257 name: ACT-62 namespace: antibiotic_resistance def: "ACT-62 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-62" EXACT CARD_Short_Name [] [Term] id: ARO:3006258 name: ACT-63 namespace: antibiotic_resistance def: "ACT-63 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-63" EXACT CARD_Short_Name [] [Term] id: ARO:3006259 name: ACT-64 namespace: antibiotic_resistance def: "ACT-64 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-64" EXACT CARD_Short_Name [] [Term] id: ARO:3006260 name: ACT-65 namespace: antibiotic_resistance def: "ACT-65 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-65" EXACT CARD_Short_Name [] [Term] id: ARO:3006261 name: ACT-66 namespace: antibiotic_resistance def: "ACT-66 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-66" EXACT CARD_Short_Name [] [Term] id: ARO:3006262 name: ACT-67 namespace: antibiotic_resistance def: "ACT-67 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-67" EXACT CARD_Short_Name [] [Term] id: ARO:3006263 name: ACT-68 namespace: antibiotic_resistance def: "ACT-68 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-68" EXACT CARD_Short_Name [] [Term] id: ARO:3006264 name: ACT-69 namespace: antibiotic_resistance def: "ACT-69 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-69" EXACT CARD_Short_Name [] [Term] id: ARO:3006265 name: ACT-70 namespace: antibiotic_resistance def: "ACT-70 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-70" EXACT CARD_Short_Name [] [Term] id: ARO:3006266 name: ACT-72 namespace: antibiotic_resistance def: "ACT-72 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-72" EXACT CARD_Short_Name [] [Term] id: ARO:3006267 name: ACT-73 namespace: antibiotic_resistance def: "ACT-73 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-73" EXACT CARD_Short_Name [] [Term] id: ARO:3006268 name: ACT-74 namespace: antibiotic_resistance def: "ACT-74 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-74" EXACT CARD_Short_Name [] [Term] id: ARO:3006269 name: ACT-75 namespace: antibiotic_resistance def: "ACT-75 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-75" EXACT CARD_Short_Name [] [Term] id: ARO:3006270 name: ACT-76 namespace: antibiotic_resistance def: "ACT-76 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-76" EXACT CARD_Short_Name [] [Term] id: ARO:3006271 name: ACT-77 namespace: antibiotic_resistance def: "ACT-77 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-77" EXACT CARD_Short_Name [] [Term] id: ARO:3006272 name: ACT-78 namespace: antibiotic_resistance def: "ACT-78 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-78" EXACT CARD_Short_Name [] [Term] id: ARO:3006273 name: ACT-79 namespace: antibiotic_resistance def: "ACT-79 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-79" EXACT CARD_Short_Name [] [Term] id: ARO:3006274 name: ACT-80 namespace: antibiotic_resistance def: "ACT-80 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-80" EXACT CARD_Short_Name [] [Term] id: ARO:3006275 name: ACT-81 namespace: antibiotic_resistance def: "ACT-81 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-81" EXACT CARD_Short_Name [] [Term] id: ARO:3006276 name: ACT-82 namespace: antibiotic_resistance def: "ACT-82 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-82" EXACT CARD_Short_Name [] [Term] id: ARO:3006277 name: ACT-83 namespace: antibiotic_resistance def: "ACT-83 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-83" EXACT CARD_Short_Name [] [Term] id: ARO:3006278 name: ACT-84 namespace: antibiotic_resistance def: "ACT-84 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-84" EXACT CARD_Short_Name [] [Term] id: ARO:3006279 name: ACT-87 namespace: antibiotic_resistance def: "ACT-87 is a ACT beta-lactamase." [] is_a: ARO:3000072 ! ACT beta-lactamase synonym: "ACT-87" EXACT CARD_Short_Name [] [Term] id: ARO:3006280 name: ADC-100 namespace: antibiotic_resistance def: "ADC-100 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-100" EXACT CARD_Short_Name [] [Term] id: ARO:3006281 name: ADC-101 namespace: antibiotic_resistance def: "ADC-101 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-101" EXACT CARD_Short_Name [] [Term] id: ARO:3006282 name: ADC-102 namespace: antibiotic_resistance def: "ADC-102 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-102" EXACT CARD_Short_Name [] [Term] id: ARO:3006283 name: ADC-103 namespace: antibiotic_resistance def: "ADC-103 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-103" EXACT CARD_Short_Name [] [Term] id: ARO:3006284 name: ADC-104 namespace: antibiotic_resistance def: "ADC-104 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-104" EXACT CARD_Short_Name [] [Term] id: ARO:3006285 name: ADC-105 namespace: antibiotic_resistance def: "ADC-105 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-105" EXACT CARD_Short_Name [] [Term] id: ARO:3006286 name: ADC-106 namespace: antibiotic_resistance def: "ADC-106 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-106" EXACT CARD_Short_Name [] [Term] id: ARO:3006287 name: ADC-107 namespace: antibiotic_resistance def: "ADC-107 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-107" EXACT CARD_Short_Name [] [Term] id: ARO:3006288 name: ADC-109 namespace: antibiotic_resistance def: "ADC-109 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-109" EXACT CARD_Short_Name [] [Term] id: ARO:3006289 name: ADC-110 namespace: antibiotic_resistance def: "ADC-110 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-110" EXACT CARD_Short_Name [] [Term] id: ARO:3006290 name: ADC-112 namespace: antibiotic_resistance def: "ADC-112 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-112" EXACT CARD_Short_Name [] [Term] id: ARO:3006291 name: ADC-113 namespace: antibiotic_resistance def: "ADC-113 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-113" EXACT CARD_Short_Name [] [Term] id: ARO:3006292 name: ADC-114 namespace: antibiotic_resistance def: "ADC-114 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-114" EXACT CARD_Short_Name [] [Term] id: ARO:3006293 name: ADC-115 namespace: antibiotic_resistance def: "ADC-115 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-115" EXACT CARD_Short_Name [] [Term] id: ARO:3006294 name: ADC-116 namespace: antibiotic_resistance def: "ADC-116 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-116" EXACT CARD_Short_Name [] [Term] id: ARO:3006295 name: ADC-117 namespace: antibiotic_resistance def: "ADC-117 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-117" EXACT CARD_Short_Name [] [Term] id: ARO:3006296 name: ADC-119 namespace: antibiotic_resistance def: "ADC-119 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-119" EXACT CARD_Short_Name [] [Term] id: ARO:3006297 name: ADC-120 namespace: antibiotic_resistance def: "ADC-120 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-120" EXACT CARD_Short_Name [] [Term] id: ARO:3006298 name: ADC-121 namespace: antibiotic_resistance def: "ADC-121 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-121" EXACT CARD_Short_Name [] [Term] id: ARO:3006299 name: ADC-122 namespace: antibiotic_resistance def: "ADC-122 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-122" EXACT CARD_Short_Name [] [Term] id: ARO:3006300 name: ADC-123 namespace: antibiotic_resistance def: "ADC-123 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-123" EXACT CARD_Short_Name [] [Term] id: ARO:3006301 name: ADC-125 namespace: antibiotic_resistance def: "ADC-125 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-125" EXACT CARD_Short_Name [] [Term] id: ARO:3006302 name: ADC-127 namespace: antibiotic_resistance def: "ADC-127 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-127" EXACT CARD_Short_Name [] [Term] id: ARO:3006303 name: ADC-128 namespace: antibiotic_resistance def: "ADC-128 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-128" EXACT CARD_Short_Name [] [Term] id: ARO:3006304 name: ADC-129 namespace: antibiotic_resistance def: "ADC-129 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-129" EXACT CARD_Short_Name [] [Term] id: ARO:3006305 name: ADC-130 namespace: antibiotic_resistance def: "ADC-130 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-130" EXACT CARD_Short_Name [] [Term] id: ARO:3006306 name: ADC-131 namespace: antibiotic_resistance def: "ADC-131 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-131" EXACT CARD_Short_Name [] [Term] id: ARO:3006307 name: ADC-132 namespace: antibiotic_resistance def: "ADC-132 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-132" EXACT CARD_Short_Name [] [Term] id: ARO:3006308 name: ADC-133 namespace: antibiotic_resistance def: "ADC-133 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-133" EXACT CARD_Short_Name [] [Term] id: ARO:3006309 name: ADC-134 namespace: antibiotic_resistance def: "ADC-134 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-134" EXACT CARD_Short_Name [] [Term] id: ARO:3006310 name: ADC-135 namespace: antibiotic_resistance def: "ADC-135 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-135" EXACT CARD_Short_Name [] [Term] id: ARO:3006311 name: ADC-136 namespace: antibiotic_resistance def: "ADC-136 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-136" EXACT CARD_Short_Name [] [Term] id: ARO:3006312 name: ADC-137 namespace: antibiotic_resistance def: "ADC-137 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-137" EXACT CARD_Short_Name [] [Term] id: ARO:3006313 name: ADC-138 namespace: antibiotic_resistance def: "ADC-138 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-138" EXACT CARD_Short_Name [] [Term] id: ARO:3006314 name: ADC-139 namespace: antibiotic_resistance def: "ADC-139 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-139" EXACT CARD_Short_Name [] [Term] id: ARO:3006315 name: ADC-140 namespace: antibiotic_resistance def: "ADC-140 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-140" EXACT CARD_Short_Name [] [Term] id: ARO:3006316 name: ADC-141 namespace: antibiotic_resistance def: "ADC-141 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-141" EXACT CARD_Short_Name [] [Term] id: ARO:3006317 name: ADC-143 namespace: antibiotic_resistance def: "ADC-143 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-143" EXACT CARD_Short_Name [] [Term] id: ARO:3006318 name: ADC-144 namespace: antibiotic_resistance def: "ADC-144 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-144" EXACT CARD_Short_Name [] [Term] id: ARO:3006319 name: ADC-145 namespace: antibiotic_resistance def: "ADC-145 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-145" EXACT CARD_Short_Name [] [Term] id: ARO:3006320 name: ADC-146 namespace: antibiotic_resistance def: "ADC-146 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-146" EXACT CARD_Short_Name [] [Term] id: ARO:3006321 name: ADC-147 namespace: antibiotic_resistance def: "ADC-147 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-147" EXACT CARD_Short_Name [] [Term] id: ARO:3006322 name: ADC-148 namespace: antibiotic_resistance def: "ADC-148 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-148" EXACT CARD_Short_Name [] [Term] id: ARO:3006323 name: ADC-149 namespace: antibiotic_resistance def: "ADC-149 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-149" EXACT CARD_Short_Name [] [Term] id: ARO:3006324 name: ADC-150 namespace: antibiotic_resistance def: "ADC-150 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-150" EXACT CARD_Short_Name [] [Term] id: ARO:3006325 name: ADC-151 namespace: antibiotic_resistance def: "ADC-151 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-151" EXACT CARD_Short_Name [] [Term] id: ARO:3006326 name: ADC-152 namespace: antibiotic_resistance def: "ADC-152 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-152" EXACT CARD_Short_Name [] [Term] id: ARO:3006327 name: ADC-153 namespace: antibiotic_resistance def: "ADC-153 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-153" EXACT CARD_Short_Name [] [Term] id: ARO:3006328 name: ADC-154 namespace: antibiotic_resistance def: "ADC-154 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-154" EXACT CARD_Short_Name [] [Term] id: ARO:3006329 name: ADC-155 namespace: antibiotic_resistance def: "ADC-155 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-155" EXACT CARD_Short_Name [] [Term] id: ARO:3006330 name: ADC-156 namespace: antibiotic_resistance def: "ADC-156 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-156" EXACT CARD_Short_Name [] [Term] id: ARO:3006331 name: ADC-157 namespace: antibiotic_resistance def: "ADC-157 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-157" EXACT CARD_Short_Name [] [Term] id: ARO:3006332 name: ADC-158 namespace: antibiotic_resistance def: "ADC-158 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-158" EXACT CARD_Short_Name [] [Term] id: ARO:3006333 name: ADC-160 namespace: antibiotic_resistance def: "ADC-160 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-160" EXACT CARD_Short_Name [] [Term] id: ARO:3006334 name: ADC-162 namespace: antibiotic_resistance def: "ADC-162 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-162" EXACT CARD_Short_Name [] [Term] id: ARO:3006335 name: ADC-163 namespace: antibiotic_resistance def: "ADC-163 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-163" EXACT CARD_Short_Name [] [Term] id: ARO:3006336 name: ADC-164 namespace: antibiotic_resistance def: "ADC-164 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-164" EXACT CARD_Short_Name [] [Term] id: ARO:3006337 name: ADC-165 namespace: antibiotic_resistance def: "ADC-165 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-165" EXACT CARD_Short_Name [] [Term] id: ARO:3006338 name: ADC-166 namespace: antibiotic_resistance def: "ADC-166 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-166" EXACT CARD_Short_Name [] [Term] id: ARO:3006339 name: ADC-167 namespace: antibiotic_resistance def: "ADC-167 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-167" EXACT CARD_Short_Name [] [Term] id: ARO:3006340 name: ADC-168 namespace: antibiotic_resistance def: "ADC-168 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-168" EXACT CARD_Short_Name [] [Term] id: ARO:3006341 name: ADC-169 namespace: antibiotic_resistance def: "ADC-169 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-169" EXACT CARD_Short_Name [] [Term] id: ARO:3006342 name: ADC-170 namespace: antibiotic_resistance def: "ADC-170 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-170" EXACT CARD_Short_Name [] [Term] id: ARO:3006343 name: ADC-171 namespace: antibiotic_resistance def: "ADC-171 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-171" EXACT CARD_Short_Name [] [Term] id: ARO:3006344 name: ADC-172 namespace: antibiotic_resistance def: "ADC-172 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-172" EXACT CARD_Short_Name [] [Term] id: ARO:3006345 name: ADC-173 namespace: antibiotic_resistance def: "ADC-173 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-173" EXACT CARD_Short_Name [] [Term] id: ARO:3006346 name: ADC-174 namespace: antibiotic_resistance def: "ADC-174 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-174" EXACT CARD_Short_Name [] [Term] id: ARO:3006347 name: ADC-175 namespace: antibiotic_resistance def: "ADC-175 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-175" EXACT CARD_Short_Name [] [Term] id: ARO:3006348 name: ADC-176 namespace: antibiotic_resistance def: "ADC-176 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-176" EXACT CARD_Short_Name [] [Term] id: ARO:3006349 name: ADC-177 namespace: antibiotic_resistance def: "ADC-177 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-177" EXACT CARD_Short_Name [] [Term] id: ARO:3006350 name: ADC-178 namespace: antibiotic_resistance def: "ADC-178 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-178" EXACT CARD_Short_Name [] [Term] id: ARO:3006351 name: ADC-179 namespace: antibiotic_resistance def: "ADC-179 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-179" EXACT CARD_Short_Name [] [Term] id: ARO:3006352 name: ADC-180 namespace: antibiotic_resistance def: "ADC-180 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-180" EXACT CARD_Short_Name [] [Term] id: ARO:3006353 name: ADC-184 namespace: antibiotic_resistance def: "ADC-184 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-184" EXACT CARD_Short_Name [] [Term] id: ARO:3006354 name: ADC-185 namespace: antibiotic_resistance def: "ADC-185 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-185" EXACT CARD_Short_Name [] [Term] id: ARO:3006355 name: ADC-186 namespace: antibiotic_resistance def: "ADC-186 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-186" EXACT CARD_Short_Name [] [Term] id: ARO:3006356 name: ADC-187 namespace: antibiotic_resistance def: "ADC-187 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-187" EXACT CARD_Short_Name [] [Term] id: ARO:3006357 name: ADC-188 namespace: antibiotic_resistance def: "ADC-188 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-188" EXACT CARD_Short_Name [] [Term] id: ARO:3006358 name: ADC-189 namespace: antibiotic_resistance def: "ADC-189 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-189" EXACT CARD_Short_Name [] [Term] id: ARO:3006359 name: ADC-190 namespace: antibiotic_resistance def: "ADC-190 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-190" EXACT CARD_Short_Name [] [Term] id: ARO:3006360 name: ADC-191 namespace: antibiotic_resistance def: "ADC-191 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-191" EXACT CARD_Short_Name [] [Term] id: ARO:3006361 name: ADC-192 namespace: antibiotic_resistance def: "ADC-192 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-192" EXACT CARD_Short_Name [] [Term] id: ARO:3006362 name: ADC-193 namespace: antibiotic_resistance def: "ADC-193 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-193" EXACT CARD_Short_Name [] [Term] id: ARO:3006363 name: ADC-194 namespace: antibiotic_resistance def: "ADC-194 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-194" EXACT CARD_Short_Name [] [Term] id: ARO:3006364 name: ADC-195 namespace: antibiotic_resistance def: "ADC-195 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-195" EXACT CARD_Short_Name [] [Term] id: ARO:3006365 name: ADC-196 namespace: antibiotic_resistance def: "ADC-196 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-196" EXACT CARD_Short_Name [] [Term] id: ARO:3006366 name: ADC-197 namespace: antibiotic_resistance def: "ADC-197 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-197" EXACT CARD_Short_Name [] [Term] id: ARO:3006367 name: ADC-198 namespace: antibiotic_resistance def: "ADC-198 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-198" EXACT CARD_Short_Name [] [Term] id: ARO:3006368 name: ADC-199 namespace: antibiotic_resistance def: "ADC-199 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-199" EXACT CARD_Short_Name [] [Term] id: ARO:3006369 name: ADC-200 namespace: antibiotic_resistance def: "ADC-200 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-200" EXACT CARD_Short_Name [] [Term] id: ARO:3006370 name: ADC-201 namespace: antibiotic_resistance def: "ADC-201 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-201" EXACT CARD_Short_Name [] [Term] id: ARO:3006371 name: ADC-202 namespace: antibiotic_resistance def: "ADC-202 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-202" EXACT CARD_Short_Name [] [Term] id: ARO:3006372 name: ADC-203 namespace: antibiotic_resistance def: "ADC-203 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-203" EXACT CARD_Short_Name [] [Term] id: ARO:3006373 name: ADC-204 namespace: antibiotic_resistance def: "ADC-204 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-204" EXACT CARD_Short_Name [] [Term] id: ARO:3006374 name: ADC-205 namespace: antibiotic_resistance def: "ADC-205 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-205" EXACT CARD_Short_Name [] [Term] id: ARO:3006375 name: ADC-206 namespace: antibiotic_resistance def: "ADC-206 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-206" EXACT CARD_Short_Name [] [Term] id: ARO:3006376 name: ADC-207 namespace: antibiotic_resistance def: "ADC-207 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-207" EXACT CARD_Short_Name [] [Term] id: ARO:3006377 name: ADC-208 namespace: antibiotic_resistance def: "ADC-208 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-208" EXACT CARD_Short_Name [] [Term] id: ARO:3006378 name: ADC-209 namespace: antibiotic_resistance def: "ADC-209 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-209" EXACT CARD_Short_Name [] [Term] id: ARO:3006379 name: ADC-210 namespace: antibiotic_resistance def: "ADC-210 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-210" EXACT CARD_Short_Name [] [Term] id: ARO:3006380 name: ADC-211 namespace: antibiotic_resistance def: "ADC-211 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-211" EXACT CARD_Short_Name [] [Term] id: ARO:3006381 name: ADC-212 namespace: antibiotic_resistance def: "ADC-212 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-212" EXACT CARD_Short_Name [] [Term] id: ARO:3006382 name: ADC-213 namespace: antibiotic_resistance def: "ADC-213 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-213" EXACT CARD_Short_Name [] [Term] id: ARO:3006383 name: ADC-214 namespace: antibiotic_resistance def: "ADC-214 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-214" EXACT CARD_Short_Name [] [Term] id: ARO:3006384 name: ADC-215 namespace: antibiotic_resistance def: "ADC-215 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-215" EXACT CARD_Short_Name [] [Term] id: ARO:3006385 name: ADC-216 namespace: antibiotic_resistance def: "ADC-216 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-216" EXACT CARD_Short_Name [] [Term] id: ARO:3006386 name: ADC-217 namespace: antibiotic_resistance def: "ADC-217 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-217" EXACT CARD_Short_Name [] [Term] id: ARO:3006387 name: ADC-218 namespace: antibiotic_resistance def: "ADC-218 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-218" EXACT CARD_Short_Name [] [Term] id: ARO:3006388 name: ADC-219 namespace: antibiotic_resistance def: "ADC-219 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-219" EXACT CARD_Short_Name [] [Term] id: ARO:3006389 name: ADC-220 namespace: antibiotic_resistance def: "ADC-220 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-220" EXACT CARD_Short_Name [] [Term] id: ARO:3006390 name: ADC-221 namespace: antibiotic_resistance def: "ADC-221 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-221" EXACT CARD_Short_Name [] [Term] id: ARO:3006391 name: ADC-222 namespace: antibiotic_resistance def: "ADC-222 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-222" EXACT CARD_Short_Name [] [Term] id: ARO:3006392 name: ADC-223 namespace: antibiotic_resistance def: "ADC-223 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-223" EXACT CARD_Short_Name [] [Term] id: ARO:3006393 name: ADC-224 namespace: antibiotic_resistance def: "ADC-224 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-224" EXACT CARD_Short_Name [] [Term] id: ARO:3006394 name: ADC-225 namespace: antibiotic_resistance def: "ADC-225 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-225" EXACT CARD_Short_Name [] [Term] id: ARO:3006395 name: ADC-226 namespace: antibiotic_resistance def: "ADC-226 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-226" EXACT CARD_Short_Name [] [Term] id: ARO:3006396 name: ADC-227 namespace: antibiotic_resistance def: "ADC-227 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-227" EXACT CARD_Short_Name [] [Term] id: ARO:3006397 name: ADC-228 namespace: antibiotic_resistance def: "ADC-228 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-228" EXACT CARD_Short_Name [] [Term] id: ARO:3006398 name: ADC-229 namespace: antibiotic_resistance def: "ADC-229 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-229" EXACT CARD_Short_Name [] [Term] id: ARO:3006399 name: ADC-230 namespace: antibiotic_resistance def: "ADC-230 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-230" EXACT CARD_Short_Name [] [Term] id: ARO:3006400 name: ADC-231 namespace: antibiotic_resistance def: "ADC-231 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-231" EXACT CARD_Short_Name [] [Term] id: ARO:3006401 name: ADC-232 namespace: antibiotic_resistance def: "ADC-232 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-232" EXACT CARD_Short_Name [] [Term] id: ARO:3006402 name: ADC-233 namespace: antibiotic_resistance def: "ADC-233 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-233" EXACT CARD_Short_Name [] [Term] id: ARO:3006403 name: ADC-234 namespace: antibiotic_resistance def: "ADC-234 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-234" EXACT CARD_Short_Name [] [Term] id: ARO:3006404 name: ADC-235 namespace: antibiotic_resistance def: "ADC-235 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-235" EXACT CARD_Short_Name [] [Term] id: ARO:3006405 name: ADC-236 namespace: antibiotic_resistance def: "ADC-236 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-236" EXACT CARD_Short_Name [] [Term] id: ARO:3006406 name: ADC-237 namespace: antibiotic_resistance def: "ADC-237 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-237" EXACT CARD_Short_Name [] [Term] id: ARO:3006407 name: ADC-238 namespace: antibiotic_resistance def: "ADC-238 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-238" EXACT CARD_Short_Name [] [Term] id: ARO:3006408 name: ADC-239 namespace: antibiotic_resistance def: "ADC-239 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-239" EXACT CARD_Short_Name [] [Term] id: ARO:3006409 name: ADC-24 namespace: antibiotic_resistance def: "ADC-24 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-24" EXACT CARD_Short_Name [] [Term] id: ARO:3006410 name: ADC-240 namespace: antibiotic_resistance def: "ADC-240 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-240" EXACT CARD_Short_Name [] [Term] id: ARO:3006411 name: ADC-241 namespace: antibiotic_resistance def: "ADC-241 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-241" EXACT CARD_Short_Name [] [Term] id: ARO:3006412 name: ADC-242 namespace: antibiotic_resistance def: "ADC-242 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-242" EXACT CARD_Short_Name [] [Term] id: ARO:3006413 name: ADC-243 namespace: antibiotic_resistance def: "ADC-243 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-243" EXACT CARD_Short_Name [] [Term] id: ARO:3006414 name: ADC-244 namespace: antibiotic_resistance def: "ADC-244 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-244" EXACT CARD_Short_Name [] [Term] id: ARO:3006415 name: ADC-245 namespace: antibiotic_resistance def: "ADC-245 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-245" EXACT CARD_Short_Name [] [Term] id: ARO:3006416 name: ADC-246 namespace: antibiotic_resistance def: "ADC-246 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-246" EXACT CARD_Short_Name [] [Term] id: ARO:3006417 name: ADC-247 namespace: antibiotic_resistance def: "ADC-247 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-247" EXACT CARD_Short_Name [] [Term] id: ARO:3006418 name: ADC-248 namespace: antibiotic_resistance def: "ADC-248 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-248" EXACT CARD_Short_Name [] [Term] id: ARO:3006419 name: ADC-249 namespace: antibiotic_resistance def: "ADC-249 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-249" EXACT CARD_Short_Name [] [Term] id: ARO:3006420 name: ADC-250 namespace: antibiotic_resistance def: "ADC-250 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-250" EXACT CARD_Short_Name [] [Term] id: ARO:3006421 name: ADC-251 namespace: antibiotic_resistance def: "ADC-251 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-251" EXACT CARD_Short_Name [] [Term] id: ARO:3006422 name: ADC-252 namespace: antibiotic_resistance def: "ADC-252 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-252" EXACT CARD_Short_Name [] [Term] id: ARO:3006423 name: ADC-253 namespace: antibiotic_resistance def: "ADC-253 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-253" EXACT CARD_Short_Name [] [Term] id: ARO:3006424 name: ADC-254 namespace: antibiotic_resistance def: "ADC-254 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-254" EXACT CARD_Short_Name [] [Term] id: ARO:3006425 name: ADC-255 namespace: antibiotic_resistance def: "ADC-255 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-255" EXACT CARD_Short_Name [] [Term] id: ARO:3006426 name: ADC-256 namespace: antibiotic_resistance def: "ADC-256 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-256" EXACT CARD_Short_Name [] [Term] id: ARO:3006427 name: ADC-29 namespace: antibiotic_resistance def: "ADC-29 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-29" EXACT CARD_Short_Name [] [Term] id: ARO:3006428 name: ADC-32 namespace: antibiotic_resistance def: "ADC-32 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-32" EXACT CARD_Short_Name [] [Term] id: ARO:3006429 name: ADC-33 namespace: antibiotic_resistance def: "ADC-33 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-33" EXACT CARD_Short_Name [] [Term] id: ARO:3006430 name: ADC-38 namespace: antibiotic_resistance def: "ADC-38 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-38" EXACT CARD_Short_Name [] [Term] id: ARO:3006431 name: ADC-51 namespace: antibiotic_resistance def: "ADC-51 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-51" EXACT CARD_Short_Name [] [Term] id: ARO:3006432 name: ADC-52 namespace: antibiotic_resistance def: "ADC-52 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-52" EXACT CARD_Short_Name [] [Term] id: ARO:3006433 name: ADC-53 namespace: antibiotic_resistance def: "ADC-53 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-53" EXACT CARD_Short_Name [] [Term] id: ARO:3006434 name: ADC-54 namespace: antibiotic_resistance def: "ADC-54 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-54" EXACT CARD_Short_Name [] [Term] id: ARO:3006435 name: ADC-57 namespace: antibiotic_resistance def: "ADC-57 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-57" EXACT CARD_Short_Name [] [Term] id: ARO:3006436 name: ADC-63 namespace: antibiotic_resistance def: "ADC-63 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-63" EXACT CARD_Short_Name [] [Term] id: ARO:3006437 name: ADC-65 namespace: antibiotic_resistance def: "ADC-65 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-65" EXACT CARD_Short_Name [] [Term] id: ARO:3006438 name: ADC-66 namespace: antibiotic_resistance def: "ADC-66 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-66" EXACT CARD_Short_Name [] [Term] id: ARO:3006439 name: ADC-70 namespace: antibiotic_resistance def: "ADC-70 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-70" EXACT CARD_Short_Name [] [Term] id: ARO:3006440 name: ADC-83 namespace: antibiotic_resistance def: "ADC-83 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-83" EXACT CARD_Short_Name [] [Term] id: ARO:3006441 name: ADC-84 namespace: antibiotic_resistance def: "ADC-84 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-84" EXACT CARD_Short_Name [] [Term] id: ARO:3006442 name: ADC-85 namespace: antibiotic_resistance def: "ADC-85 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-85" EXACT CARD_Short_Name [] [Term] id: ARO:3006443 name: ADC-86 namespace: antibiotic_resistance def: "ADC-86 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-86" EXACT CARD_Short_Name [] [Term] id: ARO:3006444 name: ADC-87 namespace: antibiotic_resistance def: "ADC-87 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-87" EXACT CARD_Short_Name [] [Term] id: ARO:3006445 name: ADC-88 namespace: antibiotic_resistance def: "ADC-88 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-88" EXACT CARD_Short_Name [] [Term] id: ARO:3006446 name: ADC-89 namespace: antibiotic_resistance def: "ADC-89 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-89" EXACT CARD_Short_Name [] [Term] id: ARO:3006447 name: ADC-90 namespace: antibiotic_resistance def: "ADC-90 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-90" EXACT CARD_Short_Name [] [Term] id: ARO:3006448 name: ADC-91 namespace: antibiotic_resistance def: "ADC-91 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-91" EXACT CARD_Short_Name [] [Term] id: ARO:3006449 name: ADC-92 namespace: antibiotic_resistance def: "ADC-92 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-92" EXACT CARD_Short_Name [] [Term] id: ARO:3006450 name: ADC-93 namespace: antibiotic_resistance def: "ADC-93 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-93" EXACT CARD_Short_Name [] [Term] id: ARO:3006451 name: ADC-94 namespace: antibiotic_resistance def: "ADC-94 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-94" EXACT CARD_Short_Name [] [Term] id: ARO:3006452 name: ADC-95 namespace: antibiotic_resistance def: "ADC-95 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-95" EXACT CARD_Short_Name [] [Term] id: ARO:3006453 name: ADC-96 namespace: antibiotic_resistance def: "ADC-96 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-96" EXACT CARD_Short_Name [] [Term] id: ARO:3006454 name: ADC-97 namespace: antibiotic_resistance def: "ADC-97 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-97" EXACT CARD_Short_Name [] [Term] id: ARO:3006455 name: ADC-98 namespace: antibiotic_resistance def: "ADC-98 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-98" EXACT CARD_Short_Name [] [Term] id: ARO:3006456 name: ADC-99 namespace: antibiotic_resistance def: "ADC-99 is a ADC beta-lactamase." [] is_a: ARO:3005460 ! ADC beta-lactamases pending classification for carbapenemase activity synonym: "ADC-99" EXACT CARD_Short_Name [] [Term] id: ARO:3006457 name: CMY-137 namespace: antibiotic_resistance def: "CMY-137 is a CMY beta-lactamase." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-137" EXACT CARD_Short_Name [] [Term] id: ARO:3006458 name: CMY-159 namespace: antibiotic_resistance def: "CMY-159 is a CMY beta-lactamase." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-159" EXACT CARD_Short_Name [] [Term] id: ARO:3006459 name: CMY-167 namespace: antibiotic_resistance def: "CMY-167 is a CMY beta-lactamase." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-167" EXACT CARD_Short_Name [] [Term] id: ARO:3006460 name: CMY-168 namespace: antibiotic_resistance def: "CMY-168 is a CMY beta-lactamase." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-168" EXACT CARD_Short_Name [] [Term] id: ARO:3006461 name: CMY-169 namespace: antibiotic_resistance def: "CMY-169 is a CMY beta-lactamase." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-169" EXACT CARD_Short_Name [] [Term] id: ARO:3006462 name: CMY-170 namespace: antibiotic_resistance def: "CMY-170 is a CMY beta-lactamase." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-170" EXACT CARD_Short_Name [] [Term] id: ARO:3006463 name: CMY-174 namespace: antibiotic_resistance def: "CMY-174 is a CMY beta-lactamase." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-174" EXACT CARD_Short_Name [] [Term] id: ARO:3006464 name: CMY-8b namespace: antibiotic_resistance def: "CMY-8b is a CMY beta-lactamase." [] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-8b" EXACT CARD_Short_Name [] [Term] id: ARO:3006465 name: DHA-24 namespace: antibiotic_resistance def: "DHA-24 is a DHA beta-lactamase." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-24" EXACT CARD_Short_Name [] [Term] id: ARO:3006466 name: DHA-25 namespace: antibiotic_resistance def: "DHA-25 is a DHA beta-lactamase." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-25" EXACT CARD_Short_Name [] [Term] id: ARO:3006467 name: DHA-26 namespace: antibiotic_resistance def: "DHA-26 is a DHA beta-lactamase." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-26" EXACT CARD_Short_Name [] [Term] id: ARO:3006468 name: DHA-27 namespace: antibiotic_resistance def: "DHA-27 is a DHA beta-lactamase." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-27" EXACT CARD_Short_Name [] [Term] id: ARO:3006469 name: DHA-28 namespace: antibiotic_resistance def: "DHA-28 is a DHA beta-lactamase." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-28" EXACT CARD_Short_Name [] [Term] id: ARO:3006470 name: DHA-29 namespace: antibiotic_resistance def: "DHA-29 is a DHA beta-lactamase." [] is_a: ARO:3000068 ! DHA beta-lactamase synonym: "DHA-29" EXACT CARD_Short_Name [] [Term] id: ARO:3006471 name: FOX-13 namespace: antibiotic_resistance def: "FOX-13 is a FOX beta-lactamase." [] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-13" EXACT CARD_Short_Name [] [Term] id: ARO:3006472 name: FOX-14 namespace: antibiotic_resistance def: "FOX-14 is a FOX beta-lactamase." [] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-14" EXACT CARD_Short_Name [] [Term] id: ARO:3006473 name: FOX-15 namespace: antibiotic_resistance def: "FOX-15 is a FOX beta-lactamase." [] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-15" EXACT CARD_Short_Name [] [Term] id: ARO:3006474 name: FOX-16 namespace: antibiotic_resistance def: "FOX-16 is a FOX beta-lactamase." [] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-16" EXACT CARD_Short_Name [] [Term] id: ARO:3006475 name: FOX-17 namespace: antibiotic_resistance def: "FOX-17 is a FOX beta-lactamase." [] is_a: ARO:3000067 ! FOX beta-lactamase synonym: "FOX-17" EXACT CARD_Short_Name [] [Term] id: ARO:3006477 name: MOX-12 namespace: antibiotic_resistance def: "MOX-12 is a MOX beta-lactamase." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-12" EXACT CARD_Short_Name [] [Term] id: ARO:3006478 name: MOX-13 namespace: antibiotic_resistance def: "MOX-13 is a MOX beta-lactamase." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-13" EXACT CARD_Short_Name [] [Term] id: ARO:3006479 name: MOX-14 namespace: antibiotic_resistance def: "MOX-14 is a MOX beta-lactamase." [] is_a: ARO:3000083 ! MOX beta-lactamase synonym: "MOX-14" EXACT CARD_Short_Name [] [Term] id: ARO:3006480 name: PDC-100 namespace: antibiotic_resistance def: "PDC-100 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-100" EXACT CARD_Short_Name [] [Term] id: ARO:3006481 name: PDC-101 namespace: antibiotic_resistance def: "PDC-101 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-101" EXACT CARD_Short_Name [] [Term] id: ARO:3006482 name: PDC-102 namespace: antibiotic_resistance def: "PDC-102 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-102" EXACT CARD_Short_Name [] [Term] id: ARO:3006483 name: PDC-103 namespace: antibiotic_resistance def: "PDC-103 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-103" EXACT CARD_Short_Name [] [Term] id: ARO:3006484 name: PDC-106 namespace: antibiotic_resistance def: "PDC-106 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-106" EXACT CARD_Short_Name [] [Term] id: ARO:3006485 name: PDC-107 namespace: antibiotic_resistance def: "PDC-107 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-107" EXACT CARD_Short_Name [] [Term] id: ARO:3006486 name: PDC-108 namespace: antibiotic_resistance def: "PDC-108 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-108" EXACT CARD_Short_Name [] [Term] id: ARO:3006487 name: PDC-109 namespace: antibiotic_resistance def: "PDC-109 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-109" EXACT CARD_Short_Name [] [Term] id: ARO:3006488 name: PDC-110 namespace: antibiotic_resistance def: "PDC-110 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-110" EXACT CARD_Short_Name [] [Term] id: ARO:3006489 name: PDC-111 namespace: antibiotic_resistance def: "PDC-111 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-111" EXACT CARD_Short_Name [] [Term] id: ARO:3006490 name: PDC-112 namespace: antibiotic_resistance def: "PDC-112 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-112" EXACT CARD_Short_Name [] [Term] id: ARO:3006491 name: PDC-113 namespace: antibiotic_resistance def: "PDC-113 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-113" EXACT CARD_Short_Name [] [Term] id: ARO:3006492 name: PDC-114 namespace: antibiotic_resistance def: "PDC-114 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-114" EXACT CARD_Short_Name [] [Term] id: ARO:3006493 name: PDC-115 namespace: antibiotic_resistance def: "PDC-115 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-115" EXACT CARD_Short_Name [] [Term] id: ARO:3006494 name: PDC-116 namespace: antibiotic_resistance def: "PDC-116 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-116" EXACT CARD_Short_Name [] [Term] id: ARO:3006495 name: PDC-12 namespace: antibiotic_resistance def: "PDC-12 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-12" EXACT CARD_Short_Name [] [Term] id: ARO:3006496 name: PDC-120 namespace: antibiotic_resistance def: "PDC-120 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-120" EXACT CARD_Short_Name [] [Term] id: ARO:3006497 name: PDC-121 namespace: antibiotic_resistance def: "PDC-121 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-121" EXACT CARD_Short_Name [] [Term] id: ARO:3006498 name: PDC-122 namespace: antibiotic_resistance def: "PDC-122 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-122" EXACT CARD_Short_Name [] [Term] id: ARO:3006499 name: PDC-123 namespace: antibiotic_resistance def: "PDC-123 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-123" EXACT CARD_Short_Name [] [Term] id: ARO:3006500 name: PDC-124 namespace: antibiotic_resistance def: "PDC-124 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-124" EXACT CARD_Short_Name [] [Term] id: ARO:3006501 name: PDC-125 namespace: antibiotic_resistance def: "PDC-125 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-125" EXACT CARD_Short_Name [] [Term] id: ARO:3006502 name: PDC-126 namespace: antibiotic_resistance def: "PDC-126 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-126" EXACT CARD_Short_Name [] [Term] id: ARO:3006503 name: PDC-127 namespace: antibiotic_resistance def: "PDC-127 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-127" EXACT CARD_Short_Name [] [Term] id: ARO:3006504 name: PDC-128 namespace: antibiotic_resistance def: "PDC-128 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-128" EXACT CARD_Short_Name [] [Term] id: ARO:3006505 name: PDC-129 namespace: antibiotic_resistance def: "PDC-129 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-129" EXACT CARD_Short_Name [] [Term] id: ARO:3006506 name: PDC-13 namespace: antibiotic_resistance def: "PDC-13 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-13" EXACT CARD_Short_Name [] [Term] id: ARO:3006507 name: PDC-130 namespace: antibiotic_resistance def: "PDC-130 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-130" EXACT CARD_Short_Name [] [Term] id: ARO:3006508 name: PDC-131 namespace: antibiotic_resistance def: "PDC-131 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-131" EXACT CARD_Short_Name [] [Term] id: ARO:3006509 name: PDC-132 namespace: antibiotic_resistance def: "PDC-132 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-132" EXACT CARD_Short_Name [] [Term] id: ARO:3006510 name: PDC-133 namespace: antibiotic_resistance def: "PDC-133 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-133" EXACT CARD_Short_Name [] [Term] id: ARO:3006511 name: PDC-134 namespace: antibiotic_resistance def: "PDC-134 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-134" EXACT CARD_Short_Name [] [Term] id: ARO:3006512 name: PDC-135 namespace: antibiotic_resistance def: "PDC-135 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-135" EXACT CARD_Short_Name [] [Term] id: ARO:3006513 name: PDC-136 namespace: antibiotic_resistance def: "PDC-136 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-136" EXACT CARD_Short_Name [] [Term] id: ARO:3006514 name: PDC-137 namespace: antibiotic_resistance def: "PDC-137 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-137" EXACT CARD_Short_Name [] [Term] id: ARO:3006515 name: PDC-138 namespace: antibiotic_resistance def: "PDC-138 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-138" EXACT CARD_Short_Name [] [Term] id: ARO:3006516 name: PDC-139 namespace: antibiotic_resistance def: "PDC-139 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-139" EXACT CARD_Short_Name [] [Term] id: ARO:3006517 name: PDC-140 namespace: antibiotic_resistance def: "PDC-140 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-140" EXACT CARD_Short_Name [] [Term] id: ARO:3006518 name: PDC-141 namespace: antibiotic_resistance def: "PDC-141 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-141" EXACT CARD_Short_Name [] [Term] id: ARO:3006519 name: PDC-142 namespace: antibiotic_resistance def: "PDC-142 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-142" EXACT CARD_Short_Name [] [Term] id: ARO:3006520 name: PDC-143 namespace: antibiotic_resistance def: "PDC-143 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-143" EXACT CARD_Short_Name [] [Term] id: ARO:3006521 name: PDC-144 namespace: antibiotic_resistance def: "PDC-144 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-144" EXACT CARD_Short_Name [] [Term] id: ARO:3006522 name: PDC-145 namespace: antibiotic_resistance def: "PDC-145 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-145" EXACT CARD_Short_Name [] [Term] id: ARO:3006523 name: PDC-146 namespace: antibiotic_resistance def: "PDC-146 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-146" EXACT CARD_Short_Name [] [Term] id: ARO:3006524 name: PDC-147 namespace: antibiotic_resistance def: "PDC-147 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-147" EXACT CARD_Short_Name [] [Term] id: ARO:3006525 name: PDC-148 namespace: antibiotic_resistance def: "PDC-148 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-148" EXACT CARD_Short_Name [] [Term] id: ARO:3006526 name: PDC-149 namespace: antibiotic_resistance def: "PDC-149 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-149" EXACT CARD_Short_Name [] [Term] id: ARO:3006527 name: PDC-15 namespace: antibiotic_resistance def: "PDC-15 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-15" EXACT CARD_Short_Name [] [Term] id: ARO:3006528 name: PDC-150 namespace: antibiotic_resistance def: "PDC-150 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-150" EXACT CARD_Short_Name [] [Term] id: ARO:3006529 name: PDC-151 namespace: antibiotic_resistance def: "PDC-151 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-151" EXACT CARD_Short_Name [] [Term] id: ARO:3006530 name: PDC-152 namespace: antibiotic_resistance def: "PDC-152 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-152" EXACT CARD_Short_Name [] [Term] id: ARO:3006531 name: PDC-153 namespace: antibiotic_resistance def: "PDC-153 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-153" EXACT CARD_Short_Name [] [Term] id: ARO:3006532 name: PDC-154 namespace: antibiotic_resistance def: "PDC-154 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-154" EXACT CARD_Short_Name [] [Term] id: ARO:3006533 name: PDC-155 namespace: antibiotic_resistance def: "PDC-155 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-155" EXACT CARD_Short_Name [] [Term] id: ARO:3006534 name: PDC-156 namespace: antibiotic_resistance def: "PDC-156 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-156" EXACT CARD_Short_Name [] [Term] id: ARO:3006535 name: PDC-157 namespace: antibiotic_resistance def: "PDC-157 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-157" EXACT CARD_Short_Name [] [Term] id: ARO:3006536 name: PDC-158 namespace: antibiotic_resistance def: "PDC-158 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-158" EXACT CARD_Short_Name [] [Term] id: ARO:3006537 name: PDC-159 namespace: antibiotic_resistance def: "PDC-159 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-159" EXACT CARD_Short_Name [] [Term] id: ARO:3006538 name: PDC-16 namespace: antibiotic_resistance def: "PDC-16 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-16" EXACT CARD_Short_Name [] [Term] id: ARO:3006539 name: PDC-160 namespace: antibiotic_resistance def: "PDC-160 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-160" EXACT CARD_Short_Name [] [Term] id: ARO:3006540 name: PDC-161 namespace: antibiotic_resistance def: "PDC-161 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-161" EXACT CARD_Short_Name [] [Term] id: ARO:3006541 name: PDC-162 namespace: antibiotic_resistance def: "PDC-162 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-162" EXACT CARD_Short_Name [] [Term] id: ARO:3006542 name: PDC-163 namespace: antibiotic_resistance def: "PDC-163 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-163" EXACT CARD_Short_Name [] [Term] id: ARO:3006543 name: PDC-164 namespace: antibiotic_resistance def: "PDC-164 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-164" EXACT CARD_Short_Name [] [Term] id: ARO:3006544 name: PDC-165 namespace: antibiotic_resistance def: "PDC-165 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-165" EXACT CARD_Short_Name [] [Term] id: ARO:3006545 name: PDC-166 namespace: antibiotic_resistance def: "PDC-166 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-166" EXACT CARD_Short_Name [] [Term] id: ARO:3006546 name: PDC-167 namespace: antibiotic_resistance def: "PDC-167 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-167" EXACT CARD_Short_Name [] [Term] id: ARO:3006547 name: PDC-168 namespace: antibiotic_resistance def: "PDC-168 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-168" EXACT CARD_Short_Name [] [Term] id: ARO:3006548 name: PDC-169 namespace: antibiotic_resistance def: "PDC-169 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-169" EXACT CARD_Short_Name [] [Term] id: ARO:3006549 name: PDC-17 namespace: antibiotic_resistance def: "PDC-17 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-17" EXACT CARD_Short_Name [] [Term] id: ARO:3006550 name: PDC-170 namespace: antibiotic_resistance def: "PDC-170 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-170" EXACT CARD_Short_Name [] [Term] id: ARO:3006551 name: PDC-171 namespace: antibiotic_resistance def: "PDC-171 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-171" EXACT CARD_Short_Name [] [Term] id: ARO:3006552 name: PDC-172 namespace: antibiotic_resistance def: "PDC-172 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-172" EXACT CARD_Short_Name [] [Term] id: ARO:3006553 name: PDC-174 namespace: antibiotic_resistance def: "PDC-174 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-174" EXACT CARD_Short_Name [] [Term] id: ARO:3006554 name: PDC-175 namespace: antibiotic_resistance def: "PDC-175 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-175" EXACT CARD_Short_Name [] [Term] id: ARO:3006555 name: PDC-176 namespace: antibiotic_resistance def: "PDC-176 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-176" EXACT CARD_Short_Name [] [Term] id: ARO:3006556 name: PDC-177 namespace: antibiotic_resistance def: "PDC-177 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-177" EXACT CARD_Short_Name [] [Term] id: ARO:3006557 name: PDC-178 namespace: antibiotic_resistance def: "PDC-178 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-178" EXACT CARD_Short_Name [] [Term] id: ARO:3006558 name: PDC-179 namespace: antibiotic_resistance def: "PDC-179 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-179" EXACT CARD_Short_Name [] [Term] id: ARO:3006559 name: PDC-18 namespace: antibiotic_resistance def: "PDC-18 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-18" EXACT CARD_Short_Name [] [Term] id: ARO:3006560 name: PDC-180 namespace: antibiotic_resistance def: "PDC-180 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-180" EXACT CARD_Short_Name [] [Term] id: ARO:3006561 name: PDC-181 namespace: antibiotic_resistance def: "PDC-181 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-181" EXACT CARD_Short_Name [] [Term] id: ARO:3006562 name: PDC-182 namespace: antibiotic_resistance def: "PDC-182 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-182" EXACT CARD_Short_Name [] [Term] id: ARO:3006563 name: PDC-184 namespace: antibiotic_resistance def: "PDC-184 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-184" EXACT CARD_Short_Name [] [Term] id: ARO:3006564 name: PDC-185 namespace: antibiotic_resistance def: "PDC-185 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-185" EXACT CARD_Short_Name [] [Term] id: ARO:3006565 name: PDC-186 namespace: antibiotic_resistance def: "PDC-186 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-186" EXACT CARD_Short_Name [] [Term] id: ARO:3006566 name: PDC-187 namespace: antibiotic_resistance def: "PDC-187 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-187" EXACT CARD_Short_Name [] [Term] id: ARO:3006567 name: PDC-188 namespace: antibiotic_resistance def: "PDC-188 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-188" EXACT CARD_Short_Name [] [Term] id: ARO:3006568 name: PDC-189 namespace: antibiotic_resistance def: "PDC-189 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-189" EXACT CARD_Short_Name [] [Term] id: ARO:3006569 name: PDC-190 namespace: antibiotic_resistance def: "PDC-190 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-190" EXACT CARD_Short_Name [] [Term] id: ARO:3006570 name: PDC-191 namespace: antibiotic_resistance def: "PDC-191 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-191" EXACT CARD_Short_Name [] [Term] id: ARO:3006571 name: PDC-192 namespace: antibiotic_resistance def: "PDC-192 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-192" EXACT CARD_Short_Name [] [Term] id: ARO:3006572 name: PDC-193 namespace: antibiotic_resistance def: "PDC-193 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-193" EXACT CARD_Short_Name [] [Term] id: ARO:3006573 name: PDC-194 namespace: antibiotic_resistance def: "PDC-194 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-194" EXACT CARD_Short_Name [] [Term] id: ARO:3006574 name: PDC-195 namespace: antibiotic_resistance def: "PDC-195 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-195" EXACT CARD_Short_Name [] [Term] id: ARO:3006575 name: PDC-196 namespace: antibiotic_resistance def: "PDC-196 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-196" EXACT CARD_Short_Name [] [Term] id: ARO:3006576 name: PDC-197 namespace: antibiotic_resistance def: "PDC-197 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-197" EXACT CARD_Short_Name [] [Term] id: ARO:3006577 name: PDC-198 namespace: antibiotic_resistance def: "PDC-198 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-198" EXACT CARD_Short_Name [] [Term] id: ARO:3006578 name: PDC-199 namespace: antibiotic_resistance def: "PDC-199 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-199" EXACT CARD_Short_Name [] [Term] id: ARO:3006579 name: PDC-20 namespace: antibiotic_resistance def: "PDC-20 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-20" EXACT CARD_Short_Name [] [Term] id: ARO:3006580 name: PDC-200 namespace: antibiotic_resistance def: "PDC-200 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-200" EXACT CARD_Short_Name [] [Term] id: ARO:3006581 name: PDC-202 namespace: antibiotic_resistance def: "PDC-202 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-202" EXACT CARD_Short_Name [] [Term] id: ARO:3006582 name: PDC-203 namespace: antibiotic_resistance def: "PDC-203 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-203" EXACT CARD_Short_Name [] [Term] id: ARO:3006583 name: PDC-204 namespace: antibiotic_resistance def: "PDC-204 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-204" EXACT CARD_Short_Name [] [Term] id: ARO:3006584 name: PDC-205 namespace: antibiotic_resistance def: "PDC-205 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-205" EXACT CARD_Short_Name [] [Term] id: ARO:3006585 name: PDC-206 namespace: antibiotic_resistance def: "PDC-206 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-206" EXACT CARD_Short_Name [] [Term] id: ARO:3006586 name: PDC-208 namespace: antibiotic_resistance def: "PDC-208 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-208" EXACT CARD_Short_Name [] [Term] id: ARO:3006587 name: PDC-209 namespace: antibiotic_resistance def: "PDC-209 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-209" EXACT CARD_Short_Name [] [Term] id: ARO:3006588 name: PDC-210 namespace: antibiotic_resistance def: "PDC-210 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-210" EXACT CARD_Short_Name [] [Term] id: ARO:3006589 name: PDC-211 namespace: antibiotic_resistance def: "PDC-211 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-211" EXACT CARD_Short_Name [] [Term] id: ARO:3006590 name: PDC-213 namespace: antibiotic_resistance def: "PDC-213 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-213" EXACT CARD_Short_Name [] [Term] id: ARO:3006591 name: PDC-214 namespace: antibiotic_resistance def: "PDC-214 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-214" EXACT CARD_Short_Name [] [Term] id: ARO:3006592 name: PDC-215 namespace: antibiotic_resistance def: "PDC-215 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-215" EXACT CARD_Short_Name [] [Term] id: ARO:3006593 name: PDC-216 namespace: antibiotic_resistance def: "PDC-216 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-216" EXACT CARD_Short_Name [] [Term] id: ARO:3006594 name: PDC-217 namespace: antibiotic_resistance def: "PDC-217 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-217" EXACT CARD_Short_Name [] [Term] id: ARO:3006595 name: PDC-218 namespace: antibiotic_resistance def: "PDC-218 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-218" EXACT CARD_Short_Name [] [Term] id: ARO:3006596 name: PDC-219 namespace: antibiotic_resistance def: "PDC-219 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-219" EXACT CARD_Short_Name [] [Term] id: ARO:3006597 name: PDC-21a namespace: antibiotic_resistance def: "PDC-21a is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-21a" EXACT CARD_Short_Name [] [Term] id: ARO:3006598 name: PDC-21b namespace: antibiotic_resistance def: "PDC-21b is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-21b" EXACT CARD_Short_Name [] [Term] id: ARO:3006599 name: PDC-22 namespace: antibiotic_resistance def: "PDC-22 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-22" EXACT CARD_Short_Name [] [Term] id: ARO:3006600 name: PDC-220 namespace: antibiotic_resistance def: "PDC-220 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-220" EXACT CARD_Short_Name [] [Term] id: ARO:3006601 name: PDC-221 namespace: antibiotic_resistance def: "PDC-221 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-221" EXACT CARD_Short_Name [] [Term] id: ARO:3006602 name: PDC-222 namespace: antibiotic_resistance def: "PDC-222 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-222" EXACT CARD_Short_Name [] [Term] id: ARO:3006603 name: PDC-223 namespace: antibiotic_resistance def: "PDC-223 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-223" EXACT CARD_Short_Name [] [Term] id: ARO:3006604 name: PDC-224 namespace: antibiotic_resistance def: "PDC-224 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-224" EXACT CARD_Short_Name [] [Term] id: ARO:3006605 name: PDC-226 namespace: antibiotic_resistance def: "PDC-226 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-226" EXACT CARD_Short_Name [] [Term] id: ARO:3006606 name: PDC-227 namespace: antibiotic_resistance def: "PDC-227 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-227" EXACT CARD_Short_Name [] [Term] id: ARO:3006607 name: PDC-228 namespace: antibiotic_resistance def: "PDC-228 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-228" EXACT CARD_Short_Name [] [Term] id: ARO:3006608 name: PDC-229 namespace: antibiotic_resistance def: "PDC-229 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-229" EXACT CARD_Short_Name [] [Term] id: ARO:3006609 name: PDC-230 namespace: antibiotic_resistance def: "PDC-230 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-230" EXACT CARD_Short_Name [] [Term] id: ARO:3006610 name: PDC-232 namespace: antibiotic_resistance def: "PDC-232 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-232" EXACT CARD_Short_Name [] [Term] id: ARO:3006611 name: PDC-233 namespace: antibiotic_resistance def: "PDC-233 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-233" EXACT CARD_Short_Name [] [Term] id: ARO:3006612 name: PDC-234 namespace: antibiotic_resistance def: "PDC-234 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-234" EXACT CARD_Short_Name [] [Term] id: ARO:3006613 name: PDC-235 namespace: antibiotic_resistance def: "PDC-235 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-235" EXACT CARD_Short_Name [] [Term] id: ARO:3006614 name: PDC-236 namespace: antibiotic_resistance def: "PDC-236 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-236" EXACT CARD_Short_Name [] [Term] id: ARO:3006615 name: PDC-237 namespace: antibiotic_resistance def: "PDC-237 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-237" EXACT CARD_Short_Name [] [Term] id: ARO:3006616 name: PDC-238 namespace: antibiotic_resistance def: "PDC-238 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-238" EXACT CARD_Short_Name [] [Term] id: ARO:3006617 name: PDC-239 namespace: antibiotic_resistance def: "PDC-239 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-239" EXACT CARD_Short_Name [] [Term] id: ARO:3006618 name: PDC-24 namespace: antibiotic_resistance def: "PDC-24 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-24" EXACT CARD_Short_Name [] [Term] id: ARO:3006619 name: PDC-241 namespace: antibiotic_resistance def: "PDC-241 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-241" EXACT CARD_Short_Name [] [Term] id: ARO:3006620 name: PDC-242 namespace: antibiotic_resistance def: "PDC-242 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-242" EXACT CARD_Short_Name [] [Term] id: ARO:3006621 name: PDC-243 namespace: antibiotic_resistance def: "PDC-243 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-243" EXACT CARD_Short_Name [] [Term] id: ARO:3006622 name: PDC-244 namespace: antibiotic_resistance def: "PDC-244 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-244" EXACT CARD_Short_Name [] [Term] id: ARO:3006623 name: PDC-245 namespace: antibiotic_resistance def: "PDC-245 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-245" EXACT CARD_Short_Name [] [Term] id: ARO:3006624 name: PDC-246 namespace: antibiotic_resistance def: "PDC-246 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-246" EXACT CARD_Short_Name [] [Term] id: ARO:3006625 name: PDC-247 namespace: antibiotic_resistance def: "PDC-247 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-247" EXACT CARD_Short_Name [] [Term] id: ARO:3006626 name: PDC-248 namespace: antibiotic_resistance def: "PDC-248 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-248" EXACT CARD_Short_Name [] [Term] id: ARO:3006627 name: PDC-249 namespace: antibiotic_resistance def: "PDC-249 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-249" EXACT CARD_Short_Name [] [Term] id: ARO:3006628 name: PDC-25 namespace: antibiotic_resistance def: "PDC-25 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-25" EXACT CARD_Short_Name [] [Term] id: ARO:3006629 name: PDC-250 namespace: antibiotic_resistance def: "PDC-250 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-250" EXACT CARD_Short_Name [] [Term] id: ARO:3006630 name: PDC-251 namespace: antibiotic_resistance def: "PDC-251 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-251" EXACT CARD_Short_Name [] [Term] id: ARO:3006631 name: PDC-252 namespace: antibiotic_resistance def: "PDC-252 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-252" EXACT CARD_Short_Name [] [Term] id: ARO:3006632 name: PDC-253 namespace: antibiotic_resistance def: "PDC-253 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-253" EXACT CARD_Short_Name [] [Term] id: ARO:3006633 name: PDC-254 namespace: antibiotic_resistance def: "PDC-254 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-254" EXACT CARD_Short_Name [] [Term] id: ARO:3006634 name: PDC-256 namespace: antibiotic_resistance def: "PDC-256 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-256" EXACT CARD_Short_Name [] [Term] id: ARO:3006635 name: PDC-259 namespace: antibiotic_resistance def: "PDC-259 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-259" EXACT CARD_Short_Name [] [Term] id: ARO:3006636 name: PDC-26 namespace: antibiotic_resistance def: "PDC-26 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-26" EXACT CARD_Short_Name [] [Term] id: ARO:3006637 name: PDC-260 namespace: antibiotic_resistance def: "PDC-260 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-260" EXACT CARD_Short_Name [] [Term] id: ARO:3006638 name: PDC-261 namespace: antibiotic_resistance def: "PDC-261 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-261" EXACT CARD_Short_Name [] [Term] id: ARO:3006639 name: PDC-262 namespace: antibiotic_resistance def: "PDC-262 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-262" EXACT CARD_Short_Name [] [Term] id: ARO:3006640 name: PDC-263 namespace: antibiotic_resistance def: "PDC-263 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-263" EXACT CARD_Short_Name [] [Term] id: ARO:3006641 name: PDC-265 namespace: antibiotic_resistance def: "PDC-265 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-265" EXACT CARD_Short_Name [] [Term] id: ARO:3006642 name: PDC-266 namespace: antibiotic_resistance def: "PDC-266 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-266" EXACT CARD_Short_Name [] [Term] id: ARO:3006643 name: PDC-267 namespace: antibiotic_resistance def: "PDC-267 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-267" EXACT CARD_Short_Name [] [Term] id: ARO:3006644 name: PDC-268 namespace: antibiotic_resistance def: "PDC-268 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-268" EXACT CARD_Short_Name [] [Term] id: ARO:3006645 name: PDC-270 namespace: antibiotic_resistance def: "PDC-270 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-270" EXACT CARD_Short_Name [] [Term] id: ARO:3006646 name: PDC-271 namespace: antibiotic_resistance def: "PDC-271 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-271" EXACT CARD_Short_Name [] [Term] id: ARO:3006647 name: PDC-273 namespace: antibiotic_resistance def: "PDC-273 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-273" EXACT CARD_Short_Name [] [Term] id: ARO:3006648 name: PDC-274 namespace: antibiotic_resistance def: "PDC-274 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-274" EXACT CARD_Short_Name [] [Term] id: ARO:3006649 name: PDC-275 namespace: antibiotic_resistance def: "PDC-275 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-275" EXACT CARD_Short_Name [] [Term] id: ARO:3006650 name: PDC-276 namespace: antibiotic_resistance def: "PDC-276 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-276" EXACT CARD_Short_Name [] [Term] id: ARO:3006651 name: PDC-277 namespace: antibiotic_resistance def: "PDC-277 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-277" EXACT CARD_Short_Name [] [Term] id: ARO:3006652 name: PDC-278 namespace: antibiotic_resistance def: "PDC-278 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-278" EXACT CARD_Short_Name [] [Term] id: ARO:3006653 name: PDC-279 namespace: antibiotic_resistance def: "PDC-279 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-279" EXACT CARD_Short_Name [] [Term] id: ARO:3006654 name: PDC-280 namespace: antibiotic_resistance def: "PDC-280 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-280" EXACT CARD_Short_Name [] [Term] id: ARO:3006655 name: PDC-281 namespace: antibiotic_resistance def: "PDC-281 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-281" EXACT CARD_Short_Name [] [Term] id: ARO:3006656 name: PDC-282 namespace: antibiotic_resistance def: "PDC-282 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-282" EXACT CARD_Short_Name [] [Term] id: ARO:3006657 name: PDC-283 namespace: antibiotic_resistance def: "PDC-283 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-283" EXACT CARD_Short_Name [] [Term] id: ARO:3006658 name: PDC-286 namespace: antibiotic_resistance def: "PDC-286 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-286" EXACT CARD_Short_Name [] [Term] id: ARO:3006659 name: PDC-287 namespace: antibiotic_resistance def: "PDC-287 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-287" EXACT CARD_Short_Name [] [Term] id: ARO:3006660 name: PDC-288 namespace: antibiotic_resistance def: "PDC-288 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-288" EXACT CARD_Short_Name [] [Term] id: ARO:3006661 name: PDC-289 namespace: antibiotic_resistance def: "PDC-289 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-289" EXACT CARD_Short_Name [] [Term] id: ARO:3006662 name: PDC-290 namespace: antibiotic_resistance def: "PDC-290 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-290" EXACT CARD_Short_Name [] [Term] id: ARO:3006663 name: PDC-291 namespace: antibiotic_resistance def: "PDC-291 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-291" EXACT CARD_Short_Name [] [Term] id: ARO:3006664 name: PDC-294 namespace: antibiotic_resistance def: "PDC-294 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-294" EXACT CARD_Short_Name [] [Term] id: ARO:3006665 name: PDC-295 namespace: antibiotic_resistance def: "PDC-295 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-295" EXACT CARD_Short_Name [] [Term] id: ARO:3006666 name: PDC-296 namespace: antibiotic_resistance def: "PDC-296 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-296" EXACT CARD_Short_Name [] [Term] id: ARO:3006667 name: PDC-297 namespace: antibiotic_resistance def: "PDC-297 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-297" EXACT CARD_Short_Name [] [Term] id: ARO:3006668 name: PDC-298 namespace: antibiotic_resistance def: "PDC-298 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-298" EXACT CARD_Short_Name [] [Term] id: ARO:3006669 name: PDC-299 namespace: antibiotic_resistance def: "PDC-299 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-299" EXACT CARD_Short_Name [] [Term] id: ARO:3006670 name: PDC-30 namespace: antibiotic_resistance def: "PDC-30 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-30" EXACT CARD_Short_Name [] [Term] id: ARO:3006671 name: PDC-300 namespace: antibiotic_resistance def: "PDC-300 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-300" EXACT CARD_Short_Name [] [Term] id: ARO:3006672 name: PDC-301 namespace: antibiotic_resistance def: "PDC-301 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-301" EXACT CARD_Short_Name [] [Term] id: ARO:3006673 name: PDC-302 namespace: antibiotic_resistance def: "PDC-302 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-302" EXACT CARD_Short_Name [] [Term] id: ARO:3006674 name: PDC-303 namespace: antibiotic_resistance def: "PDC-303 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-303" EXACT CARD_Short_Name [] [Term] id: ARO:3006675 name: PDC-304 namespace: antibiotic_resistance def: "PDC-304 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-304" EXACT CARD_Short_Name [] [Term] id: ARO:3006676 name: PDC-305 namespace: antibiotic_resistance def: "PDC-305 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-305" EXACT CARD_Short_Name [] [Term] id: ARO:3006677 name: PDC-307 namespace: antibiotic_resistance def: "PDC-307 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-307" EXACT CARD_Short_Name [] [Term] id: ARO:3006678 name: PDC-308 namespace: antibiotic_resistance def: "PDC-308 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-308" EXACT CARD_Short_Name [] [Term] id: ARO:3006679 name: PDC-309 namespace: antibiotic_resistance def: "PDC-309 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-309" EXACT CARD_Short_Name [] [Term] id: ARO:3006680 name: PDC-31 namespace: antibiotic_resistance def: "PDC-31 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-31" EXACT CARD_Short_Name [] [Term] id: ARO:3006681 name: PDC-310 namespace: antibiotic_resistance def: "PDC-310 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-310" EXACT CARD_Short_Name [] [Term] id: ARO:3006682 name: PDC-311 namespace: antibiotic_resistance def: "PDC-311 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-311" EXACT CARD_Short_Name [] [Term] id: ARO:3006683 name: PDC-312 namespace: antibiotic_resistance def: "PDC-312 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-312" EXACT CARD_Short_Name [] [Term] id: ARO:3006684 name: PDC-314 namespace: antibiotic_resistance def: "PDC-314 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-314" EXACT CARD_Short_Name [] [Term] id: ARO:3006685 name: PDC-315 namespace: antibiotic_resistance def: "PDC-315 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-315" EXACT CARD_Short_Name [] [Term] id: ARO:3006686 name: PDC-316 namespace: antibiotic_resistance def: "PDC-316 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-316" EXACT CARD_Short_Name [] [Term] id: ARO:3006687 name: PDC-317 namespace: antibiotic_resistance def: "PDC-317 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-317" EXACT CARD_Short_Name [] [Term] id: ARO:3006688 name: PDC-318 namespace: antibiotic_resistance def: "PDC-318 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-318" EXACT CARD_Short_Name [] [Term] id: ARO:3006689 name: PDC-319 namespace: antibiotic_resistance def: "PDC-319 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-319" EXACT CARD_Short_Name [] [Term] id: ARO:3006690 name: PDC-32 namespace: antibiotic_resistance def: "PDC-32 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-32" EXACT CARD_Short_Name [] [Term] id: ARO:3006691 name: PDC-320 namespace: antibiotic_resistance def: "PDC-320 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-320" EXACT CARD_Short_Name [] [Term] id: ARO:3006692 name: PDC-321 namespace: antibiotic_resistance def: "PDC-321 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-321" EXACT CARD_Short_Name [] [Term] id: ARO:3006693 name: PDC-322 namespace: antibiotic_resistance def: "PDC-322 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-322" EXACT CARD_Short_Name [] [Term] id: ARO:3006694 name: PDC-325 namespace: antibiotic_resistance def: "PDC-325 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-325" EXACT CARD_Short_Name [] [Term] id: ARO:3006695 name: PDC-326 namespace: antibiotic_resistance def: "PDC-326 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-326" EXACT CARD_Short_Name [] [Term] id: ARO:3006696 name: PDC-327 namespace: antibiotic_resistance def: "PDC-327 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-327" EXACT CARD_Short_Name [] [Term] id: ARO:3006697 name: PDC-328 namespace: antibiotic_resistance def: "PDC-328 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-328" EXACT CARD_Short_Name [] [Term] id: ARO:3006698 name: PDC-329 namespace: antibiotic_resistance def: "PDC-329 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-329" EXACT CARD_Short_Name [] [Term] id: ARO:3006699 name: PDC-33 namespace: antibiotic_resistance def: "PDC-33 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-33" EXACT CARD_Short_Name [] [Term] id: ARO:3006700 name: PDC-330 namespace: antibiotic_resistance def: "PDC-330 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-330" EXACT CARD_Short_Name [] [Term] id: ARO:3006701 name: PDC-331 namespace: antibiotic_resistance def: "PDC-331 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-331" EXACT CARD_Short_Name [] [Term] id: ARO:3006702 name: PDC-332 namespace: antibiotic_resistance def: "PDC-332 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-332" EXACT CARD_Short_Name [] [Term] id: ARO:3006703 name: PDC-333 namespace: antibiotic_resistance def: "PDC-333 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-333" EXACT CARD_Short_Name [] [Term] id: ARO:3006704 name: PDC-334 namespace: antibiotic_resistance def: "PDC-334 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-334" EXACT CARD_Short_Name [] [Term] id: ARO:3006705 name: PDC-335 namespace: antibiotic_resistance def: "PDC-335 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-335" EXACT CARD_Short_Name [] [Term] id: ARO:3006706 name: PDC-336 namespace: antibiotic_resistance def: "PDC-336 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-336" EXACT CARD_Short_Name [] [Term] id: ARO:3006707 name: PDC-338 namespace: antibiotic_resistance def: "PDC-338 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-338" EXACT CARD_Short_Name [] [Term] id: ARO:3006708 name: PDC-339 namespace: antibiotic_resistance def: "PDC-339 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-339" EXACT CARD_Short_Name [] [Term] id: ARO:3006709 name: PDC-34 namespace: antibiotic_resistance def: "PDC-34 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-34" EXACT CARD_Short_Name [] [Term] id: ARO:3006710 name: PDC-340 namespace: antibiotic_resistance def: "PDC-340 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-340" EXACT CARD_Short_Name [] [Term] id: ARO:3006711 name: PDC-341 namespace: antibiotic_resistance def: "PDC-341 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-341" EXACT CARD_Short_Name [] [Term] id: ARO:3006712 name: PDC-342 namespace: antibiotic_resistance def: "PDC-342 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-342" EXACT CARD_Short_Name [] [Term] id: ARO:3006713 name: PDC-343 namespace: antibiotic_resistance def: "PDC-343 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-343" EXACT CARD_Short_Name [] [Term] id: ARO:3006714 name: PDC-344 namespace: antibiotic_resistance def: "PDC-344 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-344" EXACT CARD_Short_Name [] [Term] id: ARO:3006715 name: PDC-345 namespace: antibiotic_resistance def: "PDC-345 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-345" EXACT CARD_Short_Name [] [Term] id: ARO:3006716 name: PDC-347 namespace: antibiotic_resistance def: "PDC-347 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-347" EXACT CARD_Short_Name [] [Term] id: ARO:3006717 name: PDC-348 namespace: antibiotic_resistance def: "PDC-348 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-348" EXACT CARD_Short_Name [] [Term] id: ARO:3006718 name: PDC-349 namespace: antibiotic_resistance def: "PDC-349 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-349" EXACT CARD_Short_Name [] [Term] id: ARO:3006719 name: PDC-35 namespace: antibiotic_resistance def: "PDC-35 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-35" EXACT CARD_Short_Name [] [Term] id: ARO:3006720 name: PDC-350 namespace: antibiotic_resistance def: "PDC-350 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-350" EXACT CARD_Short_Name [] [Term] id: ARO:3006721 name: PDC-351 namespace: antibiotic_resistance def: "PDC-351 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-351" EXACT CARD_Short_Name [] [Term] id: ARO:3006722 name: PDC-353 namespace: antibiotic_resistance def: "PDC-353 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-353" EXACT CARD_Short_Name [] [Term] id: ARO:3006723 name: PDC-354 namespace: antibiotic_resistance def: "PDC-354 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-354" EXACT CARD_Short_Name [] [Term] id: ARO:3006724 name: PDC-355 namespace: antibiotic_resistance def: "PDC-355 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-355" EXACT CARD_Short_Name [] [Term] id: ARO:3006725 name: PDC-356 namespace: antibiotic_resistance def: "PDC-356 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-356" EXACT CARD_Short_Name [] [Term] id: ARO:3006726 name: PDC-357 namespace: antibiotic_resistance def: "PDC-357 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-357" EXACT CARD_Short_Name [] [Term] id: ARO:3006727 name: PDC-358 namespace: antibiotic_resistance def: "PDC-358 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-358" EXACT CARD_Short_Name [] [Term] id: ARO:3006728 name: PDC-359 namespace: antibiotic_resistance def: "PDC-359 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-359" EXACT CARD_Short_Name [] [Term] id: ARO:3006729 name: PDC-36 namespace: antibiotic_resistance def: "PDC-36 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-36" EXACT CARD_Short_Name [] [Term] id: ARO:3006730 name: PDC-360 namespace: antibiotic_resistance def: "PDC-360 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-360" EXACT CARD_Short_Name [] [Term] id: ARO:3006731 name: PDC-361 namespace: antibiotic_resistance def: "PDC-361 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-361" EXACT CARD_Short_Name [] [Term] id: ARO:3006732 name: PDC-362 namespace: antibiotic_resistance def: "PDC-362 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-362" EXACT CARD_Short_Name [] [Term] id: ARO:3006733 name: PDC-363 namespace: antibiotic_resistance def: "PDC-363 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-363" EXACT CARD_Short_Name [] [Term] id: ARO:3006734 name: PDC-364 namespace: antibiotic_resistance def: "PDC-364 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-364" EXACT CARD_Short_Name [] [Term] id: ARO:3006735 name: PDC-365 namespace: antibiotic_resistance def: "PDC-365 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-365" EXACT CARD_Short_Name [] [Term] id: ARO:3006736 name: PDC-366 namespace: antibiotic_resistance def: "PDC-366 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-366" EXACT CARD_Short_Name [] [Term] id: ARO:3006737 name: PDC-367 namespace: antibiotic_resistance def: "PDC-367 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-367" EXACT CARD_Short_Name [] [Term] id: ARO:3006738 name: PDC-368 namespace: antibiotic_resistance def: "PDC-368 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-368" EXACT CARD_Short_Name [] [Term] id: ARO:3006739 name: PDC-369 namespace: antibiotic_resistance def: "PDC-369 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-369" EXACT CARD_Short_Name [] [Term] id: ARO:3006740 name: PDC-37 namespace: antibiotic_resistance def: "PDC-37 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-37" EXACT CARD_Short_Name [] [Term] id: ARO:3006741 name: PDC-370 namespace: antibiotic_resistance def: "PDC-370 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-370" EXACT CARD_Short_Name [] [Term] id: ARO:3006742 name: PDC-371 namespace: antibiotic_resistance def: "PDC-371 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-371" EXACT CARD_Short_Name [] [Term] id: ARO:3006743 name: PDC-372 namespace: antibiotic_resistance def: "PDC-372 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-372" EXACT CARD_Short_Name [] [Term] id: ARO:3006744 name: PDC-373 namespace: antibiotic_resistance def: "PDC-373 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-373" EXACT CARD_Short_Name [] [Term] id: ARO:3006745 name: PDC-374 namespace: antibiotic_resistance def: "PDC-374 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-374" EXACT CARD_Short_Name [] [Term] id: ARO:3006746 name: PDC-375 namespace: antibiotic_resistance def: "PDC-375 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-375" EXACT CARD_Short_Name [] [Term] id: ARO:3006747 name: PDC-377 namespace: antibiotic_resistance def: "PDC-377 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-377" EXACT CARD_Short_Name [] [Term] id: ARO:3006748 name: PDC-378 namespace: antibiotic_resistance def: "PDC-378 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-378" EXACT CARD_Short_Name [] [Term] id: ARO:3006749 name: PDC-379 namespace: antibiotic_resistance def: "PDC-379 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-379" EXACT CARD_Short_Name [] [Term] id: ARO:3006750 name: PDC-38 namespace: antibiotic_resistance def: "PDC-38 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-38" EXACT CARD_Short_Name [] [Term] id: ARO:3006751 name: PDC-381 namespace: antibiotic_resistance def: "PDC-381 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-381" EXACT CARD_Short_Name [] [Term] id: ARO:3006752 name: PDC-382 namespace: antibiotic_resistance def: "PDC-382 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-382" EXACT CARD_Short_Name [] [Term] id: ARO:3006753 name: PDC-383 namespace: antibiotic_resistance def: "PDC-383 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-383" EXACT CARD_Short_Name [] [Term] id: ARO:3006754 name: PDC-385 namespace: antibiotic_resistance def: "PDC-385 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-385" EXACT CARD_Short_Name [] [Term] id: ARO:3006755 name: PDC-386 namespace: antibiotic_resistance def: "PDC-386 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-386" EXACT CARD_Short_Name [] [Term] id: ARO:3006756 name: PDC-387 namespace: antibiotic_resistance def: "PDC-387 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-387" EXACT CARD_Short_Name [] [Term] id: ARO:3006757 name: PDC-388 namespace: antibiotic_resistance def: "PDC-388 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-388" EXACT CARD_Short_Name [] [Term] id: ARO:3006758 name: PDC-389 namespace: antibiotic_resistance def: "PDC-389 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-389" EXACT CARD_Short_Name [] [Term] id: ARO:3006759 name: PDC-39 namespace: antibiotic_resistance def: "PDC-39 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-39" EXACT CARD_Short_Name [] [Term] id: ARO:3006760 name: PDC-390 namespace: antibiotic_resistance def: "PDC-390 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-390" EXACT CARD_Short_Name [] [Term] id: ARO:3006761 name: PDC-391 namespace: antibiotic_resistance def: "PDC-391 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-391" EXACT CARD_Short_Name [] [Term] id: ARO:3006762 name: PDC-392 namespace: antibiotic_resistance def: "PDC-392 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-392" EXACT CARD_Short_Name [] [Term] id: ARO:3006763 name: PDC-394 namespace: antibiotic_resistance def: "PDC-394 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-394" EXACT CARD_Short_Name [] [Term] id: ARO:3006764 name: PDC-395 namespace: antibiotic_resistance def: "PDC-395 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-395" EXACT CARD_Short_Name [] [Term] id: ARO:3006765 name: PDC-396 namespace: antibiotic_resistance def: "PDC-396 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-396" EXACT CARD_Short_Name [] [Term] id: ARO:3006766 name: PDC-397 namespace: antibiotic_resistance def: "PDC-397 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-397" EXACT CARD_Short_Name [] [Term] id: ARO:3006767 name: PDC-398 namespace: antibiotic_resistance def: "PDC-398 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-398" EXACT CARD_Short_Name [] [Term] id: ARO:3006768 name: PDC-399 namespace: antibiotic_resistance def: "PDC-399 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-399" EXACT CARD_Short_Name [] [Term] id: ARO:3006769 name: PDC-40 namespace: antibiotic_resistance def: "PDC-40 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-40" EXACT CARD_Short_Name [] [Term] id: ARO:3006770 name: PDC-400 namespace: antibiotic_resistance def: "PDC-400 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-400" EXACT CARD_Short_Name [] [Term] id: ARO:3006771 name: PDC-401 namespace: antibiotic_resistance def: "PDC-401 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-401" EXACT CARD_Short_Name [] [Term] id: ARO:3006772 name: PDC-402 namespace: antibiotic_resistance def: "PDC-402 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-402" EXACT CARD_Short_Name [] [Term] id: ARO:3006773 name: PDC-403 namespace: antibiotic_resistance def: "PDC-403 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-403" EXACT CARD_Short_Name [] [Term] id: ARO:3006774 name: PDC-404 namespace: antibiotic_resistance def: "PDC-404 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-404" EXACT CARD_Short_Name [] [Term] id: ARO:3006775 name: PDC-405 namespace: antibiotic_resistance def: "PDC-405 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-405" EXACT CARD_Short_Name [] [Term] id: ARO:3006776 name: PDC-406 namespace: antibiotic_resistance def: "PDC-406 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-406" EXACT CARD_Short_Name [] [Term] id: ARO:3006777 name: PDC-407 namespace: antibiotic_resistance def: "PDC-407 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-407" EXACT CARD_Short_Name [] [Term] id: ARO:3006778 name: PDC-408 namespace: antibiotic_resistance def: "PDC-408 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-408" EXACT CARD_Short_Name [] [Term] id: ARO:3006779 name: PDC-409 namespace: antibiotic_resistance def: "PDC-409 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-409" EXACT CARD_Short_Name [] [Term] id: ARO:3006780 name: PDC-410 namespace: antibiotic_resistance def: "PDC-410 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-410" EXACT CARD_Short_Name [] [Term] id: ARO:3006781 name: PDC-411 namespace: antibiotic_resistance def: "PDC-411 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-411" EXACT CARD_Short_Name [] [Term] id: ARO:3006782 name: PDC-412 namespace: antibiotic_resistance def: "PDC-412 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-412" EXACT CARD_Short_Name [] [Term] id: ARO:3006783 name: PDC-414 namespace: antibiotic_resistance def: "PDC-414 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-414" EXACT CARD_Short_Name [] [Term] id: ARO:3006784 name: PDC-415 namespace: antibiotic_resistance def: "PDC-415 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-415" EXACT CARD_Short_Name [] [Term] id: ARO:3006785 name: PDC-416 namespace: antibiotic_resistance def: "PDC-416 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-416" EXACT CARD_Short_Name [] [Term] id: ARO:3006786 name: PDC-417 namespace: antibiotic_resistance def: "PDC-417 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-417" EXACT CARD_Short_Name [] [Term] id: ARO:3006787 name: PDC-418 namespace: antibiotic_resistance def: "PDC-418 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-418" EXACT CARD_Short_Name [] [Term] id: ARO:3006788 name: PDC-419 namespace: antibiotic_resistance def: "PDC-419 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-419" EXACT CARD_Short_Name [] [Term] id: ARO:3006789 name: PDC-42 namespace: antibiotic_resistance def: "PDC-42 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-42" EXACT CARD_Short_Name [] [Term] id: ARO:3006790 name: PDC-420 namespace: antibiotic_resistance def: "PDC-420 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-420" EXACT CARD_Short_Name [] [Term] id: ARO:3006791 name: PDC-421 namespace: antibiotic_resistance def: "PDC-421 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-421" EXACT CARD_Short_Name [] [Term] id: ARO:3006792 name: PDC-422 namespace: antibiotic_resistance def: "PDC-422 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-422" EXACT CARD_Short_Name [] [Term] id: ARO:3006793 name: PDC-423 namespace: antibiotic_resistance def: "PDC-423 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-423" EXACT CARD_Short_Name [] [Term] id: ARO:3006794 name: PDC-424 namespace: antibiotic_resistance def: "PDC-424 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-424" EXACT CARD_Short_Name [] [Term] id: ARO:3006795 name: PDC-425 namespace: antibiotic_resistance def: "PDC-425 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-425" EXACT CARD_Short_Name [] [Term] id: ARO:3006796 name: PDC-426 namespace: antibiotic_resistance def: "PDC-426 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-426" EXACT CARD_Short_Name [] [Term] id: ARO:3006797 name: PDC-427 namespace: antibiotic_resistance def: "PDC-427 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-427" EXACT CARD_Short_Name [] [Term] id: ARO:3006798 name: PDC-428 namespace: antibiotic_resistance def: "PDC-428 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-428" EXACT CARD_Short_Name [] [Term] id: ARO:3006799 name: PDC-430 namespace: antibiotic_resistance def: "PDC-430 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-430" EXACT CARD_Short_Name [] [Term] id: ARO:3006800 name: PDC-431 namespace: antibiotic_resistance def: "PDC-431 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-431" EXACT CARD_Short_Name [] [Term] id: ARO:3006801 name: PDC-432 namespace: antibiotic_resistance def: "PDC-432 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-432" EXACT CARD_Short_Name [] [Term] id: ARO:3006802 name: PDC-433 namespace: antibiotic_resistance def: "PDC-433 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-433" EXACT CARD_Short_Name [] [Term] id: ARO:3006803 name: PDC-434 namespace: antibiotic_resistance def: "PDC-434 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-434" EXACT CARD_Short_Name [] [Term] id: ARO:3006804 name: PDC-435 namespace: antibiotic_resistance def: "PDC-435 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-435" EXACT CARD_Short_Name [] [Term] id: ARO:3006805 name: PDC-436 namespace: antibiotic_resistance def: "PDC-436 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-436" EXACT CARD_Short_Name [] [Term] id: ARO:3006806 name: PDC-437 namespace: antibiotic_resistance def: "PDC-437 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-437" EXACT CARD_Short_Name [] [Term] id: ARO:3006807 name: PDC-439 namespace: antibiotic_resistance def: "PDC-439 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-439" EXACT CARD_Short_Name [] [Term] id: ARO:3006808 name: PDC-440 namespace: antibiotic_resistance def: "PDC-440 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-440" EXACT CARD_Short_Name [] [Term] id: ARO:3006809 name: PDC-441 namespace: antibiotic_resistance def: "PDC-441 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-441" EXACT CARD_Short_Name [] [Term] id: ARO:3006810 name: PDC-442 namespace: antibiotic_resistance def: "PDC-442 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-442" EXACT CARD_Short_Name [] [Term] id: ARO:3006811 name: PDC-443 namespace: antibiotic_resistance def: "PDC-443 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-443" EXACT CARD_Short_Name [] [Term] id: ARO:3006812 name: PDC-444 namespace: antibiotic_resistance def: "PDC-444 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-444" EXACT CARD_Short_Name [] [Term] id: ARO:3006813 name: PDC-445 namespace: antibiotic_resistance def: "PDC-445 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-445" EXACT CARD_Short_Name [] [Term] id: ARO:3006814 name: PDC-446 namespace: antibiotic_resistance def: "PDC-446 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-446" EXACT CARD_Short_Name [] [Term] id: ARO:3006815 name: PDC-447 namespace: antibiotic_resistance def: "PDC-447 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-447" EXACT CARD_Short_Name [] [Term] id: ARO:3006816 name: PDC-448 namespace: antibiotic_resistance def: "PDC-448 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-448" EXACT CARD_Short_Name [] [Term] id: ARO:3006817 name: PDC-450 namespace: antibiotic_resistance def: "PDC-450 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-450" EXACT CARD_Short_Name [] [Term] id: ARO:3006818 name: PDC-451 namespace: antibiotic_resistance def: "PDC-451 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-451" EXACT CARD_Short_Name [] [Term] id: ARO:3006819 name: PDC-452 namespace: antibiotic_resistance def: "PDC-452 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-452" EXACT CARD_Short_Name [] [Term] id: ARO:3006820 name: PDC-453 namespace: antibiotic_resistance def: "PDC-453 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-453" EXACT CARD_Short_Name [] [Term] id: ARO:3006821 name: PDC-454 namespace: antibiotic_resistance def: "PDC-454 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-454" EXACT CARD_Short_Name [] [Term] id: ARO:3006822 name: PDC-455 namespace: antibiotic_resistance def: "PDC-455 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-455" EXACT CARD_Short_Name [] [Term] id: ARO:3006823 name: PDC-456 namespace: antibiotic_resistance def: "PDC-456 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-456" EXACT CARD_Short_Name [] [Term] id: ARO:3006824 name: PDC-457 namespace: antibiotic_resistance def: "PDC-457 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-457" EXACT CARD_Short_Name [] [Term] id: ARO:3006825 name: PDC-458 namespace: antibiotic_resistance def: "PDC-458 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-458" EXACT CARD_Short_Name [] [Term] id: ARO:3006826 name: PDC-459 namespace: antibiotic_resistance def: "PDC-459 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-459" EXACT CARD_Short_Name [] [Term] id: ARO:3006827 name: PDC-46 namespace: antibiotic_resistance def: "PDC-46 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-46" EXACT CARD_Short_Name [] [Term] id: ARO:3006828 name: PDC-460 namespace: antibiotic_resistance def: "PDC-460 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-460" EXACT CARD_Short_Name [] [Term] id: ARO:3006829 name: PDC-462 namespace: antibiotic_resistance def: "PDC-462 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-462" EXACT CARD_Short_Name [] [Term] id: ARO:3006830 name: PDC-463 namespace: antibiotic_resistance def: "PDC-463 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-463" EXACT CARD_Short_Name [] [Term] id: ARO:3006831 name: PDC-465 namespace: antibiotic_resistance def: "PDC-465 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-465" EXACT CARD_Short_Name [] [Term] id: ARO:3006832 name: PDC-466 namespace: antibiotic_resistance def: "PDC-466 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-466" EXACT CARD_Short_Name [] [Term] id: ARO:3006833 name: PDC-467 namespace: antibiotic_resistance def: "PDC-467 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-467" EXACT CARD_Short_Name [] [Term] id: ARO:3006834 name: PDC-468 namespace: antibiotic_resistance def: "PDC-468 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-468" EXACT CARD_Short_Name [] [Term] id: ARO:3006835 name: PDC-469 namespace: antibiotic_resistance def: "PDC-469 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-469" EXACT CARD_Short_Name [] [Term] id: ARO:3006836 name: PDC-470 namespace: antibiotic_resistance def: "PDC-470 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-470" EXACT CARD_Short_Name [] [Term] id: ARO:3006837 name: PDC-471 namespace: antibiotic_resistance def: "PDC-471 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-471" EXACT CARD_Short_Name [] [Term] id: ARO:3006838 name: PDC-472 namespace: antibiotic_resistance def: "PDC-472 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-472" EXACT CARD_Short_Name [] [Term] id: ARO:3006839 name: PDC-473 namespace: antibiotic_resistance def: "PDC-473 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-473" EXACT CARD_Short_Name [] [Term] id: ARO:3006840 name: PDC-474 namespace: antibiotic_resistance def: "PDC-474 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-474" EXACT CARD_Short_Name [] [Term] id: ARO:3006841 name: PDC-475 namespace: antibiotic_resistance def: "PDC-475 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-475" EXACT CARD_Short_Name [] [Term] id: ARO:3006842 name: PDC-476 namespace: antibiotic_resistance def: "PDC-476 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-476" EXACT CARD_Short_Name [] [Term] id: ARO:3006843 name: PDC-58 namespace: antibiotic_resistance def: "PDC-58 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-58" EXACT CARD_Short_Name [] [Term] id: ARO:3006844 name: PDC-60 namespace: antibiotic_resistance def: "PDC-60 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-60" EXACT CARD_Short_Name [] [Term] id: ARO:3006845 name: PDC-64 namespace: antibiotic_resistance def: "PDC-64 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-64" EXACT CARD_Short_Name [] [Term] id: ARO:3006846 name: PDC-71 namespace: antibiotic_resistance def: "PDC-71 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-71" EXACT CARD_Short_Name [] [Term] id: ARO:3006847 name: PDC-94 namespace: antibiotic_resistance def: "PDC-94 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-94" EXACT CARD_Short_Name [] [Term] id: ARO:3006848 name: PDC-95 namespace: antibiotic_resistance def: "PDC-95 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-95" EXACT CARD_Short_Name [] [Term] id: ARO:3006849 name: PDC-96 namespace: antibiotic_resistance def: "PDC-96 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-96" EXACT CARD_Short_Name [] [Term] id: ARO:3006850 name: PDC-97 namespace: antibiotic_resistance def: "PDC-97 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-97" EXACT CARD_Short_Name [] [Term] id: ARO:3006851 name: PDC-98 namespace: antibiotic_resistance def: "PDC-98 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-98" EXACT CARD_Short_Name [] [Term] id: ARO:3006852 name: PDC-99 namespace: antibiotic_resistance def: "PDC-99 is a PDC beta-lactamase." [] is_a: ARO:3000098 ! PDC beta-lactamase synonym: "PDC-99" EXACT CARD_Short_Name [] [Term] id: ARO:3006853 name: SRT-3 namespace: antibiotic_resistance def: "SRT-3 is a SRT beta-lactamase." [] is_a: ARO:3000095 ! SRT beta-lactamase synonym: "SRT-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006854 name: CMH-2 namespace: antibiotic_resistance def: "CMH-2 is a CMH beta-lactamase." [] is_a: ARO:3004776 ! CMH beta-lactamase synonym: "CMH-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006855 name: CMH-3 namespace: antibiotic_resistance def: "CMH-3 is a CMH beta-lactamase." [] is_a: ARO:3004776 ! CMH beta-lactamase synonym: "CMH-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006856 name: CMH-4 namespace: antibiotic_resistance def: "CMH-4 is a CMH beta-lactamase." [] is_a: ARO:3004776 ! CMH beta-lactamase synonym: "CMH-4" EXACT CARD_Short_Name [] [Term] id: ARO:3006857 name: CMH-5 namespace: antibiotic_resistance def: "CMH-5 is a CMH beta-lactamase." [] is_a: ARO:3004776 ! CMH beta-lactamase synonym: "CMH-5" EXACT CARD_Short_Name [] [Term] id: ARO:3006858 name: CMH-6 namespace: antibiotic_resistance def: "CMH-6 is a CMH beta-lactamase." [] is_a: ARO:3004776 ! CMH beta-lactamase synonym: "CMH-6" EXACT CARD_Short_Name [] [Term] id: ARO:3006859 name: MIR-19 namespace: antibiotic_resistance def: "MIR-19 is a MIR beta-lactamase." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-19" EXACT CARD_Short_Name [] [Term] id: ARO:3006860 name: MIR-20 namespace: antibiotic_resistance def: "MIR-20 is a MIR beta-lactamase." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-20" EXACT CARD_Short_Name [] [Term] id: ARO:3006861 name: MIR-21 namespace: antibiotic_resistance def: "MIR-21 is a MIR beta-lactamase." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-21" EXACT CARD_Short_Name [] [Term] id: ARO:3006862 name: MIR-22 namespace: antibiotic_resistance def: "MIR-22 is a MIR beta-lactamase." [] is_a: ARO:3000058 ! MIR beta-lactamase synonym: "MIR-22" EXACT CARD_Short_Name [] [Term] id: ARO:3006863 name: AAK-1 namespace: antibiotic_resistance def: "AAK-1 is a AAK beta-lactamase." [] is_a: ARO:3005387 ! AAK beta-lactamase synonym: "AAK-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006864 name: CRD3-1 namespace: antibiotic_resistance def: "CRD3-1 is a CRD3 beta-lactamase." [] is_a: ARO:3005398 ! CRD3 beta-lactamase synonym: "CRD3-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006865 name: CRH-1 namespace: antibiotic_resistance def: "CRH-1 is a CRH beta-lactamase." [] is_a: ARO:3005399 ! CRH beta-lactamase synonym: "CRH-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006866 name: CRH-2 namespace: antibiotic_resistance def: "CRH-2 is a CRH beta-lactamase." [] is_a: ARO:3005399 ! CRH beta-lactamase synonym: "CRH-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006867 name: CRH-3 namespace: antibiotic_resistance def: "CRH-3 is a CRH beta-lactamase." [] is_a: ARO:3005399 ! CRH beta-lactamase synonym: "CRH-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006868 name: CRP-1 namespace: antibiotic_resistance def: "CRP-1 is a CRP beta-lactamase." [] is_a: ARO:3005400 ! CRP beta-lactamase synonym: "CRP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006869 name: CSA-1 namespace: antibiotic_resistance def: "CSA-1 is a CSA beta-lactamase." [] is_a: ARO:3005401 ! CSA beta-lactamase synonym: "CSA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006870 name: CSA-2 namespace: antibiotic_resistance def: "CSA-2 is a CSA beta-lactamase." [] is_a: ARO:3005401 ! CSA beta-lactamase synonym: "CSA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006871 name: CSP-1 namespace: antibiotic_resistance def: "CSP-1 is a CSP beta-lactamase." [] is_a: ARO:3005402 ! CSP beta-lactamase synonym: "CSP-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006872 name: DHT2-1 namespace: antibiotic_resistance def: "DHT2-1 is a DHT2 beta-lactamase." [] is_a: ARO:3005404 ! DHT2 beta-lactamase synonym: "DHT2-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006873 name: EAM-1 namespace: antibiotic_resistance def: "EAM-1 is a EAM beta-lactamase." [] is_a: ARO:3005405 ! EAM beta-lactamase synonym: "EAM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006874 name: EC-13 namespace: antibiotic_resistance def: "EC-13 is a EC beta-lactamase." [] is_a: ARO:3005406 ! EC beta-lactamase synonym: "EC-13" EXACT CARD_Short_Name [] [Term] id: ARO:3006875 name: EC-14 namespace: antibiotic_resistance def: "EC-14 is a EC beta-lactamase." [] is_a: ARO:3005406 ! EC beta-lactamase synonym: "EC-14" EXACT CARD_Short_Name [] [Term] id: ARO:3006876 name: EC-15 namespace: antibiotic_resistance def: "EC-15 is a EC beta-lactamase." [] is_a: ARO:3005406 ! EC beta-lactamase synonym: "EC-15" EXACT CARD_Short_Name [] [Term] id: ARO:3006877 name: EC-16 namespace: antibiotic_resistance def: "EC-16 is a EC beta-lactamase." [] is_a: ARO:3005406 ! EC beta-lactamase synonym: "EC-16" EXACT CARD_Short_Name [] [Term] id: ARO:3006878 name: EC-18 namespace: antibiotic_resistance def: "EC-18 is a EC beta-lactamase." [] is_a: ARO:3005406 ! EC beta-lactamase synonym: "EC-18" EXACT CARD_Short_Name [] [Term] id: ARO:3006879 name: EC-19 namespace: antibiotic_resistance def: "EC-19 is a EC beta-lactamase." [] is_a: ARO:3005406 ! EC beta-lactamase synonym: "EC-19" EXACT CARD_Short_Name [] [Term] id: ARO:3006880 name: EC-5 namespace: antibiotic_resistance def: "EC-5 is a EC beta-lactamase." [] is_a: ARO:3005406 ! EC beta-lactamase synonym: "EC-5" EXACT CARD_Short_Name [] [Term] id: ARO:3006881 name: EC-8 namespace: antibiotic_resistance def: "EC-8 is a EC beta-lactamase." [] is_a: ARO:3005406 ! EC beta-lactamase synonym: "EC-8" EXACT CARD_Short_Name [] [Term] id: ARO:3006882 name: ECM-1 namespace: antibiotic_resistance def: "ECM-1 is a ECM beta-lactamase." [] is_a: ARO:3005407 ! ECM beta-lactamase synonym: "ECM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006883 name: ECV-1 namespace: antibiotic_resistance def: "ECV-1 is a ECV beta-lactamase." [] is_a: ARO:3005408 ! ECV beta-lactamase synonym: "ECV-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006884 name: EFM-1 namespace: antibiotic_resistance def: "EFM-1 is a EFM beta-lactamase." [] is_a: ARO:3005409 ! EFM beta-lactamase synonym: "EFM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006885 name: ELM-1 namespace: antibiotic_resistance def: "ELM-1 is a ELM beta-lactamase." [] is_a: ARO:3005410 ! ELM beta-lactamase synonym: "ELM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006886 name: EVM-1 namespace: antibiotic_resistance def: "EVM-1 is a EVM beta-lactamase." [] is_a: ARO:3005411 ! EVM beta-lactamase synonym: "EVM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006887 name: FIA-1 namespace: antibiotic_resistance def: "FIA-1 is a FIA beta-lactamase." [] is_a: ARO:3005412 ! FIA beta-lactamase synonym: "FIA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006888 name: GIL-1 namespace: antibiotic_resistance def: "GIL-1 is a GIL beta-lactamase." [] is_a: ARO:3005413 ! GIL beta-lactamase synonym: "GIL-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006889 name: GMB-1 namespace: antibiotic_resistance def: "GMB-1 is a GMB beta-lactamase." [PMID:35257174] is_a: ARO:3005414 ! GMB beta-lactamase synonym: "GMB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006890 name: AFM-1 namespace: antibiotic_resistance def: "AFM-1 is a AFM beta-lactamase." [] is_a: ARO:3005388 ! AFM beta-lactamase synonym: "AFM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006891 name: AFM-2 namespace: antibiotic_resistance def: "AFM-2 is a AFM beta-lactamase." [] is_a: ARO:3005388 ! AFM beta-lactamase synonym: "AFM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006892 name: ALG11-1 namespace: antibiotic_resistance def: "ALG11-1 is a ALG11 beta-lactamase." [] is_a: ARO:3005389 ! ALG11 beta-lactamase synonym: "ALG11-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006893 name: ALG6-1 namespace: antibiotic_resistance def: "ALG6-1 is a ALG6 beta-lactamase." [] is_a: ARO:3005390 ! ALG6 beta-lactamases synonym: "ALG6-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006894 name: ALI-1 namespace: antibiotic_resistance def: "ALI-1 is a ALI beta-lactamase." [] is_a: ARO:3005391 ! ALI beta-lactamase synonym: "ALI-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006895 name: ALI-2 namespace: antibiotic_resistance def: "ALI-2 is a ALI beta-lactamase." [] is_a: ARO:3005391 ! ALI beta-lactamase synonym: "ALI-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006896 name: ANA-1 namespace: antibiotic_resistance def: "ANA-1 is a ANA beta-lactamase." [] is_a: ARO:3005392 ! ANA beta-lactamase synonym: "ANA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006897 name: AXC-1 namespace: antibiotic_resistance def: "AXC-1 is a AXC beta-lactamase." [] is_a: ARO:3005393 ! AXC beta-lactamase synonym: "AXC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006898 name: AXC-2 namespace: antibiotic_resistance def: "AXC-2 is a AXC beta-lactamase." [] is_a: ARO:3005393 ! AXC beta-lactamase synonym: "AXC-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006899 name: AXC-3 namespace: antibiotic_resistance def: "AXC-3 is a AXC beta-lactamase." [] is_a: ARO:3005393 ! AXC beta-lactamase synonym: "AXC-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006900 name: AXC-4 namespace: antibiotic_resistance def: "AXC-4 is a AXC beta-lactamase." [] is_a: ARO:3005393 ! AXC beta-lactamase synonym: "AXC-4" EXACT CARD_Short_Name [] [Term] id: ARO:3006901 name: AXC-5 namespace: antibiotic_resistance def: "AXC-5 is a AXC beta-lactamase." [] is_a: ARO:3005393 ! AXC beta-lactamase synonym: "AXC-5" EXACT CARD_Short_Name [] [Term] id: ARO:3006902 name: BSU-1 namespace: antibiotic_resistance def: "BSU-1 is a BSU beta-lactamase." [] is_a: ARO:3005394 ! BSU beta-lactamase synonym: "BSU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006903 name: CAR-1 namespace: antibiotic_resistance def: "CAR-1 is a CAR beta-lactamase." [] is_a: ARO:3005395 ! CAR beta-lactamase synonym: "CAR-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006904 name: CDD-1 namespace: antibiotic_resistance def: "CDD-1 is a CDD beta-lactamase." [] is_a: ARO:3005396 ! CDD beta-lactamase synonym: "CDD-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006905 name: CDD-2 namespace: antibiotic_resistance def: "CDD-2 is a CDD beta-lactamase." [] is_a: ARO:3005396 ! CDD beta-lactamase synonym: "CDD-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006906 name: CfiA10 namespace: antibiotic_resistance def: "CfiA10 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA10" EXACT CARD_Short_Name [] [Term] id: ARO:3006907 name: CfiA11 namespace: antibiotic_resistance def: "CfiA11 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA11" EXACT CARD_Short_Name [] [Term] id: ARO:3006908 name: CfiA14 namespace: antibiotic_resistance def: "CfiA14 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA14" EXACT CARD_Short_Name [] [Term] id: ARO:3006909 name: CfiA17 namespace: antibiotic_resistance def: "CfiA17 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA17" EXACT CARD_Short_Name [] [Term] id: ARO:3006910 name: CfiA18 namespace: antibiotic_resistance def: "CfiA18 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA18" EXACT CARD_Short_Name [] [Term] id: ARO:3006911 name: CfiA19 namespace: antibiotic_resistance def: "CfiA19 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA19" EXACT CARD_Short_Name [] [Term] id: ARO:3006912 name: CfiA2 namespace: antibiotic_resistance def: "CfiA2 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA2" EXACT CARD_Short_Name [] [Term] id: ARO:3006913 name: CfiA21 namespace: antibiotic_resistance def: "CfiA21 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA21" EXACT CARD_Short_Name [] [Term] id: ARO:3006914 name: CfiA22 namespace: antibiotic_resistance def: "CfiA22 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA22" EXACT CARD_Short_Name [] [Term] id: ARO:3006915 name: CfiA23 namespace: antibiotic_resistance def: "CfiA23 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA23" EXACT CARD_Short_Name [] [Term] id: ARO:3006916 name: CfiA24 namespace: antibiotic_resistance def: "CfiA24 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA24" EXACT CARD_Short_Name [] [Term] id: ARO:3006917 name: CfiA26 namespace: antibiotic_resistance def: "CfiA26 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA26" EXACT CARD_Short_Name [] [Term] id: ARO:3006918 name: CfiA27 namespace: antibiotic_resistance def: "CfiA27 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA27" EXACT CARD_Short_Name [] [Term] id: ARO:3006919 name: CfiA4 namespace: antibiotic_resistance def: "CfiA4 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA4" EXACT CARD_Short_Name [] [Term] id: ARO:3006920 name: CfiA8 namespace: antibiotic_resistance def: "CfiA8 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA8" EXACT CARD_Short_Name [] [Term] id: ARO:3006921 name: CfiA9 namespace: antibiotic_resistance def: "CfiA9 is a CfiA beta-lactamase." [] is_a: ARO:3004200 ! CfiA beta-lactamase synonym: "CfiA9" EXACT CARD_Short_Name [] [Term] id: ARO:3006922 name: CMA-1 namespace: antibiotic_resistance def: "CMA-1 is a CMA beta-lactamase." [] is_a: ARO:3005397 ! CMA beta-lactamase synonym: "CMA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006923 name: CMA-2 namespace: antibiotic_resistance def: "CMA-2 is a CMA beta-lactamase." [] is_a: ARO:3005397 ! CMA beta-lactamase synonym: "CMA-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006924 name: CVI-1 namespace: antibiotic_resistance def: "CVI-1 is a CVI beta-lactamase." [] is_a: ARO:3005403 ! CVI beta-lactamase synonym: "CVI-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006925 name: GRD23-1 namespace: antibiotic_resistance def: "GRD23-1 is a GRD23 beta-lactamase." [] is_a: ARO:3005415 ! GRD23 beta-lactamase synonym: "GRD23-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006926 name: GRD33-1 namespace: antibiotic_resistance def: "GRD33-1 is a GRD33 beta-lactamase." [] is_a: ARO:3005416 ! GRD33 beta-lactamase synonym: "GRD33-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006927 name: KLUC-1 namespace: antibiotic_resistance def: "KLUC-1 is a KLUC beta-lactamase." [] is_a: ARO:3005417 ! KLUC beta-lactamase synonym: "KLUC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006928 name: KLUC-2 namespace: antibiotic_resistance def: "KLUC-2 is a KLUC beta-lactamase." [] is_a: ARO:3005417 ! KLUC beta-lactamase synonym: "KLUC-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006929 name: KLUC-3 namespace: antibiotic_resistance def: "KLUC-3 is a KLUC beta-lactamase." [] is_a: ARO:3005417 ! KLUC beta-lactamase synonym: "KLUC-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006930 name: KLUC-4 namespace: antibiotic_resistance def: "KLUC-4 is a KLUC beta-lactamase." [] is_a: ARO:3005417 ! KLUC beta-lactamase synonym: "KLUC-4" EXACT CARD_Short_Name [] [Term] id: ARO:3006931 name: KLUC-5 namespace: antibiotic_resistance def: "KLUC-5 is a KLUC beta-lactamase." [] is_a: ARO:3005417 ! KLUC beta-lactamase synonym: "KLUC-5" EXACT CARD_Short_Name [] [Term] id: ARO:3006932 name: LEN-27 namespace: antibiotic_resistance def: "LEN-27 is a LEN beta-lactamase." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-27" EXACT CARD_Short_Name [] [Term] id: ARO:3006933 name: LEN-28 namespace: antibiotic_resistance def: "LEN-28 is a LEN beta-lactamase." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-28" EXACT CARD_Short_Name [] [Term] id: ARO:3006934 name: LEN-31 namespace: antibiotic_resistance def: "LEN-31 is a LEN beta-lactamase." [] is_a: ARO:3000097 ! LEN beta-lactamase synonym: "LEN-31" EXACT CARD_Short_Name [] [Term] id: ARO:3006935 name: LHK-1 namespace: antibiotic_resistance def: "LHK-1 is a LHK beta-lactamase." [] is_a: ARO:3005418 ! LHK beta-lactamase synonym: "LHK-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006936 name: LHK-2 namespace: antibiotic_resistance def: "LHK-2 is a LHK beta-lactamase." [] is_a: ARO:3005418 ! LHK beta-lactamase synonym: "LHK-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006937 name: LHK-3 namespace: antibiotic_resistance def: "LHK-3 is a LHK beta-lactamase." [] is_a: ARO:3005418 ! LHK beta-lactamase synonym: "LHK-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006938 name: LHK-4 namespace: antibiotic_resistance def: "LHK-4 is a LHK beta-lactamase." [] is_a: ARO:3005418 ! LHK beta-lactamase synonym: "LHK-4" EXACT CARD_Short_Name [] [Term] id: ARO:3006939 name: LHK-5 namespace: antibiotic_resistance def: "LHK-5 is a LHK beta-lactamase." [] is_a: ARO:3005418 ! LHK beta-lactamase synonym: "LHK-5" EXACT CARD_Short_Name [] [Term] id: ARO:3006940 name: LHK-6 namespace: antibiotic_resistance def: "LHK-6 is a LHK beta-lactamase." [] is_a: ARO:3005418 ! LHK beta-lactamase synonym: "LHK-6" EXACT CARD_Short_Name [] [Term] id: ARO:3006941 name: LRG-1 namespace: antibiotic_resistance def: "LRG-1 is a LRG beta-lactamase." [] is_a: ARO:3005419 ! LRG beta-lactamase synonym: "LRG-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006942 name: LUS-1 namespace: antibiotic_resistance def: "LUS-1 is a LUS beta-lactamase." [] is_a: ARO:3005420 ! LUS beta-lactamase synonym: "LUS-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006943 name: LUT-1 namespace: antibiotic_resistance def: "LUT-1 is a LUT beta-lactamase." [] is_a: ARO:3005421 ! LUT beta-lactamase synonym: "LUT-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006944 name: LUT-2 namespace: antibiotic_resistance def: "LUT-2 is a LUT beta-lactamase." [] is_a: ARO:3005421 ! LUT beta-lactamase synonym: "LUT-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006945 name: LUT-3 namespace: antibiotic_resistance def: "LUT-3 is a LUT beta-lactamase." [] is_a: ARO:3005421 ! LUT beta-lactamase synonym: "LUT-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006946 name: LUT-4 namespace: antibiotic_resistance def: "LUT-4 is a LUT beta-lactamase." [] is_a: ARO:3005421 ! LUT beta-lactamase synonym: "LUT-4" EXACT CARD_Short_Name [] [Term] id: ARO:3006947 name: LUT-5 namespace: antibiotic_resistance def: "LUT-5 is a LUT beta-lactamase." [] is_a: ARO:3005421 ! LUT beta-lactamase synonym: "LUT-5" EXACT CARD_Short_Name [] [Term] id: ARO:3006948 name: LUT-6 namespace: antibiotic_resistance def: "LUT-6 is a LUT beta-lactamase." [] is_a: ARO:3005421 ! LUT beta-lactamase synonym: "LUT-6" EXACT CARD_Short_Name [] [Term] id: ARO:3006949 name: MAL-1 namespace: antibiotic_resistance def: "MAL-1 is a MAL beta-lactamase." [] is_a: ARO:3005422 ! MAL beta-lactamase synonym: "MAL-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006950 name: MAL-2 namespace: antibiotic_resistance def: "MAL-2 is a MAL beta-lactamase." [] is_a: ARO:3005422 ! MAL beta-lactamase synonym: "MAL-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006951 name: MBL1b namespace: antibiotic_resistance def: "MBL1b is a MBL beta-lactamase." [] is_a: ARO:3005423 ! MBL beta-lactamase synonym: "MBL1b" EXACT CARD_Short_Name [] [Term] id: ARO:3006952 name: MOC-1 namespace: antibiotic_resistance def: "MOC-1 is a MOC beta-lactamase." [] is_a: ARO:3005424 ! MOC beta-lactamase synonym: "MOC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006953 name: MOR-2 namespace: antibiotic_resistance def: "MOR-2 is a MOR beta-lactamase." [] is_a: ARO:3005425 ! MOR beta-lactamase synonym: "MOR-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006954 name: MYO-1 namespace: antibiotic_resistance def: "MYO-1 is a MYO beta-lactamase." [] is_a: ARO:3005426 ! MYO beta-lactamase synonym: "MYO-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006955 name: MYX-1 namespace: antibiotic_resistance def: "MYX-1 is a MYX beta-lactamase." [] is_a: ARO:3005427 ! MYX beta-lactamase synonym: "MYX-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006956 name: OHIO-1 namespace: antibiotic_resistance def: "OHIO-1 is a OHIO beta-lactamase." [] is_a: ARO:3005428 ! OHIO beta-lactamase synonym: "OHIO-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006957 name: ORN-1 namespace: antibiotic_resistance def: "ORN-1 is a ORN beta-lactamase." [] is_a: ARO:3005429 ! ORN beta-lactamase synonym: "ORN-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006958 name: ORN-2 namespace: antibiotic_resistance def: "ORN-2 is a ORN beta-lactamase." [] is_a: ARO:3005429 ! ORN beta-lactamase synonym: "ORN-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006959 name: ORN-3 namespace: antibiotic_resistance def: "ORN-3 is a ORN beta-lactamase." [] is_a: ARO:3005429 ! ORN beta-lactamase synonym: "ORN-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006960 name: ORN-4 namespace: antibiotic_resistance def: "ORN-4 is a ORN beta-lactamase." [] is_a: ARO:3005429 ! ORN beta-lactamase synonym: "ORN-4" EXACT CARD_Short_Name [] [Term] id: ARO:3006961 name: ORN-5 namespace: antibiotic_resistance def: "ORN-5 is a ORN beta-lactamase." [] is_a: ARO:3005429 ! ORN beta-lactamase synonym: "ORN-5" EXACT CARD_Short_Name [] [Term] id: ARO:3006962 name: ORN-6 namespace: antibiotic_resistance def: "ORN-6 is a ORN beta-lactamase." [] is_a: ARO:3005429 ! ORN beta-lactamase synonym: "ORN-6" EXACT CARD_Short_Name [] [Term] id: ARO:3006963 name: ORR-1 namespace: antibiotic_resistance def: "ORR-1 is a ORR beta-lactamase." [] is_a: ARO:3005430 ! ORR beta-lactamase synonym: "ORR-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006964 name: PAU-1 namespace: antibiotic_resistance def: "PAU-1 is a PAU beta-lactamase." [] is_a: ARO:3005431 ! PAU beta-lactamase synonym: "PAU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006965 name: PFM-1 namespace: antibiotic_resistance def: "PFM-1 is a PFM beta-lactamase." [] is_a: ARO:3005432 ! PFM beta-lactamase synonym: "PFM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006966 name: PFM-2 namespace: antibiotic_resistance def: "PFM-2 is a PFM beta-lactamase." [] is_a: ARO:3005432 ! PFM beta-lactamase synonym: "PFM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006967 name: PFM-3 namespace: antibiotic_resistance def: "PFM-3 is a PFM beta-lactamase." [] is_a: ARO:3005432 ! PFM beta-lactamase synonym: "PFM-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006968 name: PLA-1 namespace: antibiotic_resistance def: "PLA-1 is a PLA beta-lactamase." [] is_a: ARO:3005433 ! PLA beta-lactamase synonym: "PLA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006969 name: PLA-2a namespace: antibiotic_resistance def: "PLA-2a is a PLA beta-lactamase." [] is_a: ARO:3005433 ! PLA beta-lactamase synonym: "PLA-2a" EXACT CARD_Short_Name [] [Term] id: ARO:3006970 name: PLA-3 namespace: antibiotic_resistance def: "PLA-3 is a PLA beta-lactamase." [] is_a: ARO:3005433 ! PLA beta-lactamase synonym: "PLA-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006971 name: PLA-6 namespace: antibiotic_resistance def: "PLA-6 is a PLA beta-lactamase." [] is_a: ARO:3005433 ! PLA beta-lactamase synonym: "PLA-6" EXACT CARD_Short_Name [] [Term] id: ARO:3006972 name: PLN-1 namespace: antibiotic_resistance def: "PLN-1 is a PLN beta-lactamase." [] is_a: ARO:3005434 ! PLN beta-lactamase synonym: "PLN-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006973 name: PME-1 namespace: antibiotic_resistance def: "PME-1 is a PME beta-lactamase." [] is_a: ARO:3005435 ! PME beta-lactamase synonym: "PME-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006974 name: POM-1 namespace: antibiotic_resistance def: "POM-1 is a POM beta-lactamase." [] is_a: ARO:3005436 ! POM beta-lactamase synonym: "POM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006975 name: POM-2 namespace: antibiotic_resistance def: "POM-2 is a POM beta-lactamase." [] is_a: ARO:3005436 ! POM beta-lactamase synonym: "POM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006976 name: PST-1 namespace: antibiotic_resistance def: "PST-1 is a PST beta-lactamase." [] is_a: ARO:3005437 ! PST beta-lactamase synonym: "PST-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006977 name: PST-2 namespace: antibiotic_resistance def: "PST-2 is a PST beta-lactamase." [] is_a: ARO:3005437 ! PST beta-lactamase synonym: "PST-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006978 name: PSV-1 namespace: antibiotic_resistance def: "PSV-1 is a PSV beta-lactamase." [] is_a: ARO:3005438 ! PSV beta-lactamase synonym: "PSV-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006979 name: RAHN-1 namespace: antibiotic_resistance def: "RAHN-1 is a RAHN beta-lactamase." [] is_a: ARO:3005439 ! RAHN beta-lactamase synonym: "RAHN-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006980 name: RAHN-2 namespace: antibiotic_resistance def: "RAHN-2 is a RAHN beta-lactamase." [] is_a: ARO:3005439 ! RAHN beta-lactamase synonym: "RAHN-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006981 name: RSA2-1 namespace: antibiotic_resistance def: "RSA2-1 is a RSA2 beta-lactamase." [PMID:29316517] is_a: ARO:3005440 ! RSA2 beta-lactamase synonym: "RSA2-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006982 name: RSD2-1 namespace: antibiotic_resistance def: "RSD2-1 is a RSD2 beta-lactamase." [] is_a: ARO:3005441 ! RSD2 beta-lactamase synonym: "RSD2-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006983 name: RSD2-2 namespace: antibiotic_resistance def: "RSD2-2 is a RSD2 beta-lactamase." [] is_a: ARO:3005441 ! RSD2 beta-lactamase synonym: "RSD2-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006984 name: RUB-1 namespace: antibiotic_resistance def: "RUB-1 is a RUB beta-lactamase." [] is_a: ARO:3005442 ! RUB beta-lactamase synonym: "RUB-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006985 name: SFC-1 namespace: antibiotic_resistance def: "SFC-1 is a SFC beta-lactamase." [] is_a: ARO:3005443 ! SFC beta-lactamase synonym: "SFC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006986 name: SFO-1 namespace: antibiotic_resistance def: "SFO-1 is a SFO beta-lactamase." [] is_a: ARO:3005444 ! SFO beta-lactamase synonym: "SFO-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006987 name: SGM-1 namespace: antibiotic_resistance def: "SGM-1 is a SGM beta-lactamase." [] is_a: ARO:3005445 ! SGM beta-lactamase synonym: "SGM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006988 name: SGM-2 namespace: antibiotic_resistance def: "SGM-2 is a SGM beta-lactamase." [] is_a: ARO:3005445 ! SGM beta-lactamase synonym: "SGM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3006989 name: SGM-3 namespace: antibiotic_resistance def: "SGM-3 is a SGM beta-lactamase." [] is_a: ARO:3005445 ! SGM beta-lactamase synonym: "SGM-3" EXACT CARD_Short_Name [] [Term] id: ARO:3006990 name: SGM-4 namespace: antibiotic_resistance def: "SGM-4 is a SGM beta-lactamase." [] is_a: ARO:3005445 ! SGM beta-lactamase synonym: "SGM-4" EXACT CARD_Short_Name [] [Term] id: ARO:3006991 name: SGM-5 namespace: antibiotic_resistance def: "SGM-5 is a SGM beta-lactamase." [] is_a: ARO:3005445 ! SGM beta-lactamase synonym: "SGM-5" EXACT CARD_Short_Name [] [Term] id: ARO:3006992 name: SGM-6 namespace: antibiotic_resistance def: "SGM-6 is a SGM beta-lactamase." [] is_a: ARO:3005445 ! SGM beta-lactamase synonym: "SGM-6" EXACT CARD_Short_Name [] [Term] id: ARO:3006993 name: SGM-7 namespace: antibiotic_resistance def: "SGM-7 is a SGM beta-lactamase." [] is_a: ARO:3005445 ! SGM beta-lactamase synonym: "SGM-7" EXACT CARD_Short_Name [] [Term] id: ARO:3006994 name: SHN-1 namespace: antibiotic_resistance def: "SHN-1 is a SHN beta-lactamase." [] is_a: ARO:3005446 ! SHN beta-lactamase synonym: "SHN-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006995 name: SPN79-1 namespace: antibiotic_resistance def: "SPN79-1 is a SPN79 beta-lactamase." [] is_a: ARO:3005447 ! SPN79 beta-lactamase synonym: "SPN79-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006996 name: SPR-1 namespace: antibiotic_resistance def: "SPR-1 is a SPR beta-lactamase." [] is_a: ARO:3005448 ! SPR beta-lactamase synonym: "SPR-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006997 name: SPS-1 namespace: antibiotic_resistance def: "SPS-1 is a SPS beta-lactamase." [] is_a: ARO:3005449 ! SPS beta-lactamase synonym: "SPS-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006998 name: SPU-1 namespace: antibiotic_resistance def: "SPU-1 is a SPU beta-lactamase." [] is_a: ARO:3005450 ! SPU beta-lactamase synonym: "SPU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3006999 name: SST-1 namespace: antibiotic_resistance def: "SST-1 is a SST beta-lactamase." [] is_a: ARO:3005451 ! SST beta-lactamase synonym: "SST-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007000 name: STA-1 namespace: antibiotic_resistance def: "STA-1 is a STA beta-lactamase." [] is_a: ARO:3005452 ! STA beta-lactamase synonym: "STA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007001 name: TER-1 namespace: antibiotic_resistance def: "TER-1 is a TER beta-lactamase." [] is_a: ARO:3005453 ! TER beta-lactamase synonym: "TER-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007002 name: TTU-1 namespace: antibiotic_resistance def: "TTU-1 is a TTU beta-lactamase." [] is_a: ARO:3005454 ! TTU beta-lactamase synonym: "TTU-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007003 name: VHH-1 namespace: antibiotic_resistance def: "VHH-1 is a VHH beta-lactamase." [] is_a: ARO:3005455 ! VHH beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "VHH-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007004 name: VHW-1 namespace: antibiotic_resistance def: "VHW-1 is a VHW beta-lactamase." [] is_a: ARO:3005456 ! VHW beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "VHW-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007005 name: YEM-1 namespace: antibiotic_resistance def: "YEM-1 is a YEM beta-lactamase." [] is_a: ARO:3005457 ! YEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem synonym: "YEM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007006 name: ZOG-1 namespace: antibiotic_resistance def: "ZOG-1 is a ZOG beta-lactamase." [] is_a: ARO:3005458 ! ZOG beta-lactamase synonym: "ZOG-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007007 name: TER-2 namespace: antibiotic_resistance def: "TER-2 is a TER beta-lactamase." [] is_a: ARO:3005453 ! TER beta-lactamase synonym: "TER-2" EXACT CARD_Short_Name [] [Term] id: ARO:3007008 name: diazabicyclooctane namespace: antibiotic_resistance def: "A class of serine beta-lactamase inhibitors." [] is_a: ARO:3007128 ! serine beta-lactamase inhibitor [Term] id: ARO:3007009 name: ANT3310 namespace: antibiotic_resistance def: "An experimental diazabicyclooctane beta-lactamase inhibitor that contains a fluorine atom in place of the carboxamide." [PMID:33306385] is_a: ARO:3007008 ! diazabicyclooctane relationship: is_small_molecule_inhibitor ARO:3000873 ! TEM-1 relationship: is_small_molecule_inhibitor ARO:3001418 ! OXA-23 relationship: is_small_molecule_inhibitor ARO:3001782 ! OXA-48 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 xref: pubchem.compound:153516440 [Term] id: ARO:3007010 name: norC namespace: antibiotic_resistance def: "NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR." [PMID:16495280, PMID:23929475] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: regulates ARO:3000391 ! norA synonym: "norC" EXACT CARD_Short_Name [] [Term] id: ARO:3007011 name: mdeA namespace: antibiotic_resistance def: "mdeA is a multidrug efflux pump that confers resistance in varying degrees to several unrelated antibiotics, including kanamycin, tetracycline, ampicillin, oxacillin, ciprofloxacin, nalidixic acid, acriflavine, and ethidium bromide." [PMID:23462018] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000056 ! oxacillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid synonym: "mdeA" EXACT CARD_Short_Name [] [Term] id: ARO:3007012 name: sepA namespace: antibiotic_resistance def: "sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes." [PMID:12499635] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000045 ! acriflavine relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics synonym: "sepA" EXACT CARD_Short_Name [] [Term] id: ARO:3007013 name: sdrM namespace: antibiotic_resistance def: "sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene." [PMID:16508166] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_drug_class ARO:3005386 ! disinfecting agents and antiseptics synonym: "SA1972" EXACT [] synonym: "sdrM" EXACT CARD_Short_Name [] [Term] id: ARO:3007014 name: qacJ namespace: antibiotic_resistance def: "qacJ is a small multidrug resistance (SMR) efflux pump that confers resistance to quaternary ammonium compounds." [PMID:14506007] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3003823 ! benzalkonium chloride synonym: "qacJ" EXACT CARD_Short_Name [] [Term] id: ARO:3007015 name: qacG namespace: antibiotic_resistance def: "qacG is a small multidrug resistance efflux pump that confers resistance to benzalkonium chloride and ethidium bromide." [PMID:10196743] is_a: ARO:0010003 ! small multidrug resistance (SMR) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3003823 ! benzalkonium chloride synonym: "qacG" EXACT CARD_Short_Name [] [Term] id: ARO:3007016 name: SHD beta-lactamase namespace: antibiotic_resistance def: "SHD beta-lactamases are class B1 beta-lactamases found in Shewanella denitrificans." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3007017 name: SHD-1 namespace: antibiotic_resistance def: "SHD-1 is a SHD beta-lactamase." [PMID:29020980] is_a: ARO:3007016 ! SHD beta-lactamase synonym: "SHD-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007018 name: CARD Short Name namespace: antibiotic_resistance def: "A CARD-specific abbreviation for AMR gene names associated with Antibiotic Resistance Ontology terms, often not based on the literature. This is used for programmatic and compatibility purposes and is not ontologically relevant. Each ontology term with an associated AMR detection model has a CARD Short Name that appears in CARD data files and output generated by RGI. If the original gene name is less than 15 characters, the CARD short name is identical; if the gene name is greater than 15 characters, the CARD Short Name has been abbreviated by CARD curators specifically to identify the proper gene or protein name. All CARD Short Names are unique and have whitespace characters replaced by underscore characters. The convention for pathogen names is capitalized first letter of the genus followed by the lowercase first three letters of the species name. The antibiotic abbreviations are from https://journals.asm.org/journal/aac/abbreviations plus some custom abbreviations by the CARD curators. Simple CARD Short Names often do not involve either, e.g. CTX-M-15, but where applicable the CARD Short Names follow pathogen_gene or pathogen_gene_drug. The full lists of abbreviations can be found in the CARD Downloads: https://card.mcmaster.ca/latest/data." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: ARO:3007019 name: fexB namespace: antibiotic_resistance def: "FexB is a plasmid-encoded exporter gene which confers resistance to florfenicol. Originally identified in Enterococcus sp. isolated from swine by Liu et al. 2012." [PMID:22096043] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3000461 ! florfenicol synonym: "fexB" EXACT CARD_Short_Name [] [Term] id: ARO:3007021 name: PFM-4 namespace: antibiotic_resistance def: "PFM-4 (BioF) is a class B2 metallo-beta-lactamase first identified in Pseudomonas. It belongs to the PFM-like beta-lactamase gene family. It confers resistance to carbapenems and some cephalosporins." [PMID:34725905] is_a: ARO:3005432 ! PFM beta-lactamase synonym: "BioF" EXACT [] synonym: "PFM-4" EXACT CARD_Short_Name [] [Term] id: ARO:3007022 name: Prulifloxacin namespace: antibiotic_resistance def: "Prulifloxacin is a 6-fluoroquinolone antibiotic with a C-2 sulfur atom. It is hydrolyzed by esterases to produce the active compound Ulifloxacin. The active compound has broad spectrum activity against most Gram-negative bacteria. Prulifloxacin displays strong bactericidal activity against Pseudomonas aeruginosa biofilms and persister cells." [PMID:9531524, PMID:1667252, PMID:34905092] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:65947 [Term] id: ARO:3007023 name: NDM-33 namespace: antibiotic_resistance def: "NDM-33 confers resistance to all beta-lactam antibiotics except aztreonam. It was first identified in an E. coli strain isolated from hospital sewage. It differs from NDM-5 by a single amino acid substitution (A72T)." [PMID:34643418] is_a: ARO:3000057 ! NDM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "NDM-33" EXACT CARD_Short_Name [] [Term] id: ARO:3007024 name: Lascufloxacin namespace: antibiotic_resistance def: "Lascufloxacin is a fluoroquinolone antibiotic." [PMID:28320717] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:71528768 [Term] id: ARO:3007025 name: Sarecycline namespace: antibiotic_resistance def: "Sarecycline is a tetracycline derivative." [PMID:30397052] is_a: ARO:3000050 ! tetracycline antibiotic xref: pubchem.compound:54681908 [Term] id: ARO:3007026 name: salB namespace: antibiotic_resistance def: "salB is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins." [PMID:35137182] is_a: ARO:3007030 ! sal-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin synonym: "sal(B)" EXACT [] synonym: "salB" EXACT CARD_Short_Name [] [Term] id: ARO:3007027 name: salC namespace: antibiotic_resistance def: "salC is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins." [PMID:35137182] is_a: ARO:3007030 ! sal-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin synonym: "sal(C)" EXACT [] synonym: "salC" EXACT CARD_Short_Name [] [Term] id: ARO:3007028 name: salD namespace: antibiotic_resistance def: "salD is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins." [PMID:35137182] is_a: ARO:3007030 ! sal-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin synonym: "salD" EXACT CARD_Short_Name [] [Term] id: ARO:3007029 name: salE namespace: antibiotic_resistance def: "salE is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins." [PMID:35137182] is_a: ARO:3007030 ! sal-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin synonym: "sal(E)" EXACT [] synonym: "salE" EXACT CARD_Short_Name [] [Term] id: ARO:3007030 name: sal-type ABC-F protein namespace: antibiotic_resistance def: "Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection." [PMID:35137182] is_a: ARO:3004469 ! ABC-F ATP-binding cassette ribosomal protection protein relationship: confers_resistance_to_drug_class ARO:0000017 ! lincosamide antibiotic relationship: confers_resistance_to_drug_class ARO:0000034 ! streptogramin A antibiotic relationship: confers_resistance_to_drug_class ARO:3000670 ! pleuromutilin antibiotic [Term] id: ARO:3007031 name: relebactam namespace: antibiotic_resistance def: "A serine beta-lactamase inhibitor that prevents the degradation of imipenem in the body." [] is_a: ARO:3007008 ! diazabicyclooctane relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 relationship: is_small_molecule_inhibitor ARO:3002313 ! KPC-3 relationship: is_small_molecule_inhibitor ARO:3002314 ! KPC-4 relationship: is_small_molecule_inhibitor ARO:3002500 ! PDC-3 xref: pubchem.compound:44129647 [Term] id: ARO:3007032 name: Erm(50) namespace: antibiotic_resistance def: "Erm(50) is an Erm ribosomal RNA methyltransferase." [PMID:31844016] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000027 ! roxithromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "Erm(50)" EXACT CARD_Short_Name [] [Term] id: ARO:3007033 name: Erm(51) namespace: antibiotic_resistance def: "Erm(51) is an Erm ribosomal RNA methyltransferase." [PMID:32291839] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000065 ! clarithromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_antibiotic ARO:3000675 ! pristinamycin IB synonym: "Erm(51)" EXACT CARD_Short_Name [] [Term] id: ARO:3007034 name: tetracenomycin antibiotic namespace: antibiotic_resistance def: "Tetracenomycin antibiotics are aromatic polyketides that inhibit translation by binding to the large ribosomal subunit within the polypeptide exit tunnel." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007035 name: tetracenomycin C namespace: antibiotic_resistance def: "Tetracenomycin C is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone." [PMID:11851469] is_a: ARO:3007034 ! tetracenomycin antibiotic xref: pubchem.compound:73632 [Term] id: ARO:3007036 name: tetracenomycin X namespace: antibiotic_resistance def: "Tetracenomycin X is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone." [PMID:32601485] is_a: ARO:3007034 ! tetracenomycin antibiotic xref: pubchem.compound:129395 [Term] id: ARO:3007037 name: tetracenomycin A2 namespace: antibiotic_resistance def: "Tetracenomycin A2 is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone." [] is_a: ARO:3007034 ! tetracenomycin antibiotic xref: pubchem.compound:134024 [Term] id: ARO:3007039 name: chlorhexidine namespace: antibiotic_resistance def: "Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate)." [] is_a: ARO:3005386 ! disinfecting agents and antiseptics synonym: "chlorhexidine acetate" EXACT [] synonym: "chlorhexidine digluconate" EXACT [] synonym: "chlorhexidine gluconate" EXACT [] xref: pubchem.compound:9552079 [Term] id: ARO:3007040 name: cefotaxime-ceftiofur-tazobactam-clavulanate namespace: antibiotic_resistance def: "A combination therapy for multidrug resistant pathogens consisting of two cephalosporin antibiotics (cefotaxime and ceftiofur) with two beta-lactamase inhibitors (tazobactam and clavulanate) encapsulated in a nanoparticle. They were shown to have efficient antimicrobial activity against multidrug resistant extended-spectrum beta-lactamase producing Enterobacteriaceae." [PMID:34920071] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000077 ! tazobactam relationship: has_part ARO:0000079 ! clavulanic acid relationship: has_part ARO:3000645 ! cefotaxime relationship: has_part ARO:3004006 ! ceftiofur [Term] id: ARO:3007041 name: Erm(52) namespace: antibiotic_resistance def: "Erm(52) is an Erm ribosomal RNA methyltransferase." [PMID:33956520] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin synonym: "Erm(52)" EXACT CARD_Short_Name [] [Term] id: ARO:3007042 name: msr(G) namespace: antibiotic_resistance def: "msr(G) is a part of the msr subfamily of ABC-F ribosomal protection proteins." [PMID:33118027] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "msr(G)" EXACT CARD_Short_Name [] synonym: "msrG" EXACT [] [Term] id: ARO:3007043 name: msr(I) namespace: antibiotic_resistance def: "msr(I) is part of the msr subfamily of ABC-F ribosomal protection proteins." [] is_a: ARO:3004471 ! msr-type ABC-F protein relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "msr(I)" EXACT CARD_Short_Name [] synonym: "msrI" EXACT [] [Term] id: ARO:3007044 name: mef(F) namespace: antibiotic_resistance def: "mef(F) is an mef efflux pump protein." [PMID:33118027] is_a: ARO:3000747 ! mef relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin synonym: "mef(F)" EXACT CARD_Short_Name [] synonym: "mefF" EXACT [] [Term] id: ARO:3007045 name: enrofloxacin namespace: antibiotic_resistance def: "Enrofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats but is sometimes used for other animals." [PMID:9278889] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:71188 [Term] id: ARO:3007046 name: marbofloxacin namespace: antibiotic_resistance def: "Marbofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats." [] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:60651 [Term] id: ARO:3007047 name: mef(H) namespace: antibiotic_resistance def: "mef(H) is an mef efflux pump protein." [PMID:33956520] is_a: ARO:3000747 ! mef synonym: "mef(H)" EXACT CARD_Short_Name [] synonym: "mefH" EXACT [] [Term] id: ARO:3007048 name: Xeruborbactam namespace: antibiotic_resistance def: "Xeruborbactam is an experimental cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lactamases and metallo-beta-lactamases." [PMID:34902261] is_a: ARO:3007131 ! boronic acid beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000882 ! TEM-10 relationship: is_small_molecule_inhibitor ARO:3001071 ! SHV-12 relationship: is_small_molecule_inhibitor ARO:3001418 ! OXA-23 relationship: is_small_molecule_inhibitor ARO:3001782 ! OXA-48 relationship: is_small_molecule_inhibitor ARO:3001877 ! CTX-M-14 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 synonym: "QPX7728" EXACT [] xref: pubchem.compound:140830474 [Term] id: ARO:3007049 name: mef(J) namespace: antibiotic_resistance def: "mef(J) is an mef efflux pump protein." [] is_a: ARO:3000747 ! mef synonym: "mef(J)" EXACT CARD_Short_Name [] synonym: "mefJ" EXACT [] [Term] id: ARO:3007050 name: mreA namespace: antibiotic_resistance def: "mreA is a macrolide efflux pump." [PMID:9420045] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:3000156 ! spiramycin relationship: confers_resistance_to_antibiotic ARO:3000158 ! azithromycin relationship: confers_resistance_to_drug_class ARO:0000000 ! macrolide antibiotic synonym: "mreA" EXACT CARD_Short_Name [] [Term] id: ARO:3007051 name: Helicobacter pylori rpoB mutation conferring resistance to rifampicin namespace: antibiotic_resistance def: "Rifampicin inhibits transcription by binding the beta subunit of RNA polymerase. Helicobacter pylori mutations associated with rifampicin resistance typically occur in the rifampicin resistance determining region of rpoB between codons 525 and 586." [PMID:30815255, PMID:10348780, PMID:17350989, PMID:30774400, PMID:10817737] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "Hpyl_rpoB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3007052 name: Helicobacter pylori gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in the quinolone resistance-determining regions of Helicobacter pylori observed to confer resistance to fluoroquinolone antibiotics." [PMID:32471292, PMID:28018334, PMID:27906990, PMID:38089809, PMID:25499186, PMID:22064536, PMID:22515359, PMID:27809767, PMID:21762270] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin synonym: "Hpyl_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3007053 name: Helicobacter pylori gyrB conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in Helicobacter pylori conferring resistance to fluoroquinolone antibiotics." [PMID:22221614, PMID:25003707, PMID:21793912, PMID:30774400] is_a: ARO:3000864 ! fluoroquinolone resistant gyrB relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin synonym: "Hpyl_gyrB_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3007055 name: Helicobacter pylori rdxA mutation conferring resistance to metronidazole namespace: antibiotic_resistance def: "The rdxA gene in Helicobacter pylori encodes an NADPH nitroreductase. Mutations in this gene are associated with metronidazole resistance." [PMID:30621024, PMID:33593015, PMID:24827414, PMID:31744181, PMID:32099422, PMID:10681326, PMID:27809767, PMID:37485536, PMID:21801504, PMID:9622362] is_a: ARO:3007056 ! Antibiotic resistant Helicobacter pylori nitroreductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "Hpyl_rdxA_MTZ" EXACT CARD_Short_Name [] [Term] id: ARO:3007056 name: Antibiotic resistant Helicobacter pylori nitroreductase namespace: antibiotic_resistance def: "Inactivation of the oxygen-insensitive NADPH nitroreductases in Helicobacter pylori play a role in metronidazole resistance." [PMID:11489869] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole relationship: confers_resistance_to_drug_class ARO:3004115 ! nitroimidazole antibiotic [Term] id: ARO:3007057 name: Helicobacter pylori pbp3 conferring resistance to amoxicillin namespace: antibiotic_resistance def: "Point mutations in Helicobacter pylori pbp3 observed to confer resistance to amoxicillin." [PMID:18276599, PMID:31801839] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin synonym: "Hpyl_pbp3_AMX" EXACT CARD_Short_Name [] [Term] id: ARO:3007058 name: Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin namespace: antibiotic_resistance def: "Point mutations in Helicobacter pylori pbp2 observed to confer resistance to amoxicillin." [PMID:18276599, PMID:31801839] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin synonym: "Hpyl_pbp2_AMX" EXACT CARD_Short_Name [] [Term] id: ARO:3007059 name: Helicobacter pylori frxA mutation conferring resistance to metronidazole namespace: antibiotic_resistance def: "FrxA encodes an NADH-flavin oxidoreductase in Helicobacter pylori. Mutations in this gene confer resistance to nitrofuran antibiotics and metronidazole." [PMID:32099422, PMID:21801504, PMID:25132107, PMID:33593015, PMID:27809767, PMID:30621024] is_a: ARO:3007056 ! Antibiotic resistant Helicobacter pylori nitroreductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "Hpyl_fxrA_MTZ" EXACT CARD_Short_Name [] [Term] id: ARO:3007060 name: Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin namespace: antibiotic_resistance def: "Point mutations in Helicobacter pylori pbp1 observed to confer resistance to amoxicillin." [PMID:37485536, PMID:35114945, PMID:18192681, PMID:32708761, PMID:31801839, PMID:17951983, PMID:32545318] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin synonym: "Hpyl_pbp1_AMX" EXACT CARD_Short_Name [] [Term] id: ARO:3007061 name: hp1165 namespace: antibiotic_resistance def: "Hp1165 is a homolog of the Clostridium perfringes tetP gene and is part of the MFS efflux family but is not considered a true tetracycline resistance gene. Hp1165 confers low level resistance to tetracycline, however cessation of antibiotic treatment results in the host cell reverting to susceptibility." [PMID:16482431] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline [Term] id: ARO:3007062 name: VAM-1 namespace: antibiotic_resistance def: "VAM-1 is a subclass B1 metallo-beta-lactamase, conferring resistance to beta-lactam antibiotics such as carbapenems and cephalosporins." [PMID:34424042] is_a: ARO:3007065 ! VAM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime synonym: "VAM-1" EXACT CARD_Short_Name [] synonym: "VAM1" EXACT [] [Term] id: ARO:3007063 name: cilastatin namespace: antibiotic_resistance def: "Cilastatin is often prescribed with imipenem as a beta-lactam potentiator. Cilastatin inhibits enzymatic renal dehydropeptidase, which hydrolyzes imipenem, thereby preventing the metabolism of imipenem in vivo and maintaining longer antibiotic exposure and effect." [] is_a: ARO:3007226 ! host-related antibiotic adjuvants xref: pubchem.compound:6435415 [Term] id: ARO:3007065 name: VAM beta-lactamase namespace: antibiotic_resistance def: "VAM beta-lactamases are class B1 beta-lactamases found in Vibrio alginolyticus." [] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3007066 name: mg/L namespace: antibiotic_resistance def: "Milligrams per Litre (mg/L)." [] is_a: ARO:3004372 ! MIC unit [Term] id: ARO:3007067 name: mm namespace: antibiotic_resistance def: "Millimeters (mm)." [] is_a: ARO:3004372 ! MIC unit [Term] id: ARO:3007068 name: Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins namespace: antibiotic_resistance def: "ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification." [] is_a: ARO:3004469 ! ABC-F ATP-binding cassette ribosomal protection protein [Term] id: ARO:3007069 name: FosY namespace: antibiotic_resistance def: "A thiol transferase isolated in Staphylococcus aureus that leads to resistance of fosfomycin." [PMID:35332834] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosY" EXACT CARD_Short_Name [] [Term] id: ARO:3007070 name: MCR-1.33 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant, first described in a multi-drug-resistant Escherichia coli isolate recovered from a urinary tract infection, and co-occurring with the carbapenemase NDM-5." [PMID:35411158] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B relationship: evolutionary_variant_of ARO:3003689 ! MCR-1.1 synonym: "MCR-1.33" EXACT CARD_Short_Name [] [Term] id: ARO:3007072 name: ceftazidime-avibactam namespace: antibiotic_resistance def: "An antibiotic-adjuvant admixture of the beta-lactam antibiotic ceftazidime and the non-beta-lactam beta-lactamase inhibitor avibactam." [PMID:29671219, PMID:23371303] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000060 ! ceftazidime relationship: has_part ARO:3000588 ! avibactam xref: pubchem.compound:77050660 [Term] id: ARO:3007073 name: Bacillus subtilis rpoB mutants conferring resistance to rifampin namespace: antibiotic_resistance def: "Point mutations that occur within the Bacillus subtilis rpoB gene resulting in resistance to rifampin." [PMID:7657605, PMID:12169622, PMID:11101662] is_a: ARO:3000210 ! rifamycin-resistant beta-subunit of RNA polymerase (rpoB) relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "Bsub_rpoB_RIF" EXACT CARD_Short_Name [] [Term] id: ARO:3007074 name: capreomycin phosphotransferase namespace: antibiotic_resistance def: "Capreomycin family of phosphotransferases confer resistance to capreomycin antibiotics." [PMID:6163840] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic relationship: participates_in ARO:3000105 ! phosphorylation of antibiotic conferring resistance [Term] id: ARO:3007075 name: cph namespace: antibiotic_resistance def: "cph is a phosphotransferase that confers resistance to capreomycin." [PMID:34994196, PMID:6163840] is_a: ARO:3007074 ! capreomycin phosphotransferase relationship: confers_resistance_to_antibiotic ARO:3003993 ! capreomycin synonym: "cph" EXACT CARD_Short_Name [] [Term] id: ARO:3007076 name: emerione A namespace: antibiotic_resistance def: "A fungal secondary metabolite which inhibits the action of New Delhi metallo-beta-lactamase 1." [PMID:35017068] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 xref: pubchem.compound:146683214 [Term] id: ARO:3007077 name: inhibitors of MsrA efflux pump namespace: antibiotic_resistance def: "Molecules and compounds that decrease resistance by inhibiting the action of the MrsA efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007078 name: Luteolin namespace: antibiotic_resistance def: "Luteolin is a flavonoid produced by a variety of plants that features a wide range of biological effects. It has been shown to inhibit the action of the MsrA drug efflux pump." [PMID:35012652, PMID:18991571] is_a: ARO:3007077 ! inhibitors of MsrA efflux pump synonym: "3',4',5,7-Tetrahydroxyflavone" EXACT [] synonym: "Digitoflavone" EXACT [] synonym: "Luteolol" EXACT [] xref: pubchem.compound:5280445 [Term] id: ARO:3007079 name: Pellitorine namespace: antibiotic_resistance def: "Pellitorine is a metabolite produced mainly in members of the Zanthoxylum, Tetradium, and Piper genera. It has been shown to inhibit the action of the MsrA drug efflux pump." [PMID:32449250] is_a: ARO:3007077 ! inhibitors of MsrA efflux pump synonym: "Pellitorin" EXACT [] xref: pubchem.compound:5318516 [Term] id: ARO:3007080 name: Piperic acid namespace: antibiotic_resistance def: "Piperic acid is a compound produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump." [PMID:32449250] is_a: ARO:3007077 ! inhibitors of MsrA efflux pump synonym: "Piperonic acid" EXACT [] xref: pubchem.compound:5370536 [Term] id: ARO:3007081 name: Tetrahydropiperine namespace: antibiotic_resistance def: "Tetraydropiperine is a derivative of piperine produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump." [PMID:32449250] is_a: ARO:3007077 ! inhibitors of MsrA efflux pump synonym: "Cosmoperine" EXACT [] synonym: "Tetrahydropiperin" EXACT [] xref: pubchem.compound:581676 [Term] id: ARO:3007082 name: Sesamin namespace: antibiotic_resistance def: "Sesamin is a compound isolated from sesame oil and bark from plants in the Zanthoxylum genus. It has been shown to inhibit the action of the MsrA drug efflux pump." [PMID:32449250] is_a: ARO:3007077 ! inhibitors of MsrA efflux pump synonym: "Asarinin" EXACT [] synonym: "Episesamin" EXACT [] synonym: "Fagarol" EXACT [] synonym: "Fsesamin" EXACT [] synonym: "Pseudocubebin" EXACT [] synonym: "Sezamin" EXACT [] xref: pubchem.compound:72307 [Term] id: ARO:3007083 name: biapenem namespace: antibiotic_resistance def: "Biapenem is a broad spectrum injectable antibiotic belonging to the carbapenem subgroup of beta-lactams." [PMID:8031067, PMID:12381221] is_a: ARO:0000020 ! carbapenem synonym: "Biapenern" EXACT [] synonym: "Bipenem" EXACT [] synonym: "Omegacin" EXACT [] xref: pubchem.compound:71339 [Term] id: ARO:3007084 name: PRC beta-lactamase namespace: antibiotic_resistance def: "PRC beta-lactamases are class C beta-lactamases." [PMID:34975778] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007085 name: PRC-1 namespace: antibiotic_resistance def: "PRC-1 is a beta-lactamase that confers resistance to certain cephalosporins and penicillins." [PMID:34975778] is_a: ARO:3007084 ! PRC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime synonym: "PRC-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007086 name: epinecidin-1 namespace: antibiotic_resistance def: "Epinecidin-1 is a peptide antibiotic derived from Epinephelus coioides with broad spectrum activity against a range or Gram positive and Gram negative bacteria." [PMID:17570764] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:49769423 [Term] id: ARO:3007087 name: KPC-90 namespace: antibiotic_resistance def: "KPC-90 is a KPC beta-lactamase." [PMID:35019766] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-90" EXACT CARD_Short_Name [] [Term] id: ARO:3007088 name: murepavadin namespace: antibiotic_resistance def: "A peptidomimetic antibiotic with specific, potent action against members of the Pseudomonas genus. Murepavadin disrupts lipopolysaccharide biosynthesis by binding to lypopolysaccharide transport protein D." [PMID:20167788, PMID:33367642] is_a: ARO:3007162 ! protegrin-1-like antibiotic synonym: "POL7080" EXACT [] xref: pubchem.compound:91824766 [Term] id: ARO:3007089 name: KPC-83 namespace: antibiotic_resistance def: "KPC-83 is a KPC beta-lactamase. Sequence data were made available through NCBI without publication." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-83" EXACT CARD_Short_Name [] [Term] id: ARO:3007090 name: albendazole namespace: antibiotic_resistance def: "Albendazole is a compound used in the treatment of parasitic worm infestations. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis." [PMID:35453279] is_a: ARO:3007163 ! albendazole-like antibiotic synonym: "Albendazol" EXACT [] synonym: "Albendazolum" EXACT [] synonym: "Albenza" EXACT [] synonym: "Bilutac" EXACT [] synonym: "Eskazole" EXACT [] synonym: "Proftril" EXACT [] synonym: "Valbazen" EXACT [] synonym: "Zentel" EXACT [] xref: pubchem.compound:2082 [Term] id: ARO:3007091 name: diflunisal namespace: antibiotic_resistance def: "Diflunisal is a salicylic acid derivative and aspirin analogue typically used as a nonsteroidal anti-inflammatory drug. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis." [PMID:35453279] is_a: ARO:3007159 ! salicylic acid antibiotic synonym: "Adomal" EXACT [] synonym: "Dolobid" EXACT [] synonym: "Dolobis" EXACT [] synonym: "Flovacil" EXACT [] synonym: "Fluniget" EXACT [] synonym: "Fluodonil" EXACT [] synonym: "Flustar" EXACT [] xref: pubchem.compound:3059 [Term] id: ARO:3007092 name: gepotidacin namespace: antibiotic_resistance def: "Gepotidacin is a triazaacenaphthylene bacterial type II topoisomerase inhibitor used experimentally. It has been in phase III of clinical trials since 2019 for the treatment of gonorrhea, however gepotidacin has demonstrated antibiotic activity against a variety of bacteria." [PMID:26729499] is_a: ARO:3007164 ! triazaacenaphthylene antibiotic xref: pubchem.compound:25101874 [Term] id: ARO:3007093 name: klebsidin namespace: antibiotic_resistance def: "Klebsidin is a peptide antibiotic derived from Klebsiella pneumoniae that exhibits activity against members of the Enterobacteriaceae family of Gram-negative bacteria, including Escherichia and Salmonella species. Klebsidin acts by accumulating in the target cell and inhibiting RNA polymerase." [PMID:35315272] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:146684527 [Term] id: ARO:3007094 name: fisetin namespace: antibiotic_resistance def: "Fisetin is a flavonoid produced mainly by plants in the Eudicotidae clade. It exhibits a range of biological activities such as anti-inflammatory and antioxidant properties, and fisetin has been shown to inhibit the action of metallo-beta-lactamases." [PMID:35101651] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 synonym: "Cotinin" EXACT [] synonym: "Fustel" EXACT [] synonym: "Viset" EXACT [] xref: pubchem.compound:5281614 [Term] id: ARO:3007095 name: risedronate namespace: antibiotic_resistance def: "Risedronate is a bisphosphonate used as an oral medication to treat osteoperosis and Paget's disease of bone. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1." [PMID:35209073] is_a: ARO:3007134 ! phosphonate metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 synonym: "Actonel" EXACT [] synonym: "Atelvia" EXACT [] synonym: "Benet" EXACT [] synonym: "Risedronic acid" EXACT [] xref: pubchem.compound:5245 [Term] id: ARO:3007096 name: methotrexate namespace: antibiotic_resistance def: "Methotrexate is an antifolate chemotherapeutic and immune suppressant used to treat a wide variety of cancers and autoimmune diseases. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1." [PMID:35209073] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 synonym: "Otrexup" EXACT [] synonym: "Rheumatrex" EXACT [] synonym: "Trexall" EXACT [] xref: pubchem.compound:126941 [Term] id: ARO:3007097 name: FosM1 namespace: antibiotic_resistance def: "FosM1 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin." [PMID:33199384] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosM1" EXACT CARD_Short_Name [] [Term] id: ARO:3007098 name: FosM2 namespace: antibiotic_resistance def: "FosM2 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin." [PMID:33199384] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosM2" EXACT CARD_Short_Name [] [Term] id: ARO:3007099 name: FosM3 namespace: antibiotic_resistance def: "FosM3 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin." [PMID:33199384] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosM3" EXACT CARD_Short_Name [] [Term] id: ARO:3007100 name: class A Bacillus cereus Bc beta-lactamase namespace: antibiotic_resistance def: "Class A Bacillus cereus Bc beta-lactamases are enzymes that break down beta-lactam antibiotics, particularly penicillins." [PMID:29551437] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3007101 name: BcIII namespace: antibiotic_resistance def: "Bacillus cereus beta-lactamase III is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in Bacillus cereus." [PMID:29551437] is_a: ARO:3007100 ! class A Bacillus cereus Bc beta-lactamase synonym: "BcIII" EXACT CARD_Short_Name [] [Term] id: ARO:3007102 name: KPC-93 namespace: antibiotic_resistance def: "KPC-93 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase synonym: "KPC-93" EXACT CARD_Short_Name [] [Term] id: ARO:3007103 name: nitroimidazole reductase namespace: antibiotic_resistance def: "Nitroimidazole reductases are a group of enzymes that deactivate nitroimidazole antibiotics by reducing their nitro functional group to an amino group. These enzymes are associated with resistance to nitroimidazole derivatives in Bacteroides fragilis but have also been reported in a variety of anaerobic Gram-negative and Gram-positive genera. The minimum inhibitory concentrations for these enzymes vary greatly depending on species, strain, and precise nitroimidazole treatment used." [PMID:10970359, PMID:30316817] is_a: ARO:3000557 ! antibiotic inactivation enzyme relationship: confers_resistance_to_drug_class ARO:3004115 ! nitroimidazole antibiotic [Term] id: ARO:3007104 name: nimA namespace: antibiotic_resistance def: "nimA is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment." [PMID:8067736, PMID:10970359] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimA" EXACT CARD_Short_Name [] [Term] id: ARO:3007105 name: nimC namespace: antibiotic_resistance def: "nimC is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment." [PMID:7773395, PMID:10970359] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimC" EXACT CARD_Short_Name [] [Term] id: ARO:3007106 name: nimD namespace: antibiotic_resistance def: "nimD is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment." [PMID:7773395, PMID:10970359] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimD" EXACT CARD_Short_Name [] [Term] id: ARO:3007107 name: nimE namespace: antibiotic_resistance def: "nimE is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment." [PMID:15273153, PMID:10970359] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimE" EXACT CARD_Short_Name [] [Term] id: ARO:3007108 name: nimF namespace: antibiotic_resistance def: "nimF is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics." [PMID:15728943] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimF" EXACT CARD_Short_Name [] [Term] id: ARO:3007109 name: nimG namespace: antibiotic_resistance def: "nimG is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics." [PMID:15190033] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimG" EXACT CARD_Short_Name [] [Term] id: ARO:3007110 name: nimH namespace: antibiotic_resistance def: "nimH is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment." [PMID:28535278] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimH" EXACT CARD_Short_Name [] [Term] id: ARO:3007111 name: nimI namespace: antibiotic_resistance def: "nimI is a nitroimidazole reductase discovered in the Prevotella baroniae that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Although not found in Bacteroids fragilis, the source organism of most nim genes, nimI shares significant similarity with other nitroimidazole reductases. nimI is chromosomally encoded in P. baroniae, suggesting that it is intrinsic to this species." [PMID:19805556] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimI" EXACT CARD_Short_Name [] [Term] id: ARO:3007112 name: nimJ namespace: antibiotic_resistance def: "nimJ is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment." [PMID:23716049] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimJ" EXACT CARD_Short_Name [] [Term] id: ARO:3007113 name: nimK namespace: antibiotic_resistance def: "nimK is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment." [PMID:29982676] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "nimK" EXACT CARD_Short_Name [] [Term] id: ARO:3007114 name: ornidazole namespace: antibiotic_resistance def: "Ornidazole is a synthetic nitroimidazole derivative mainly used to treat parasitic infections but has also demonstrated antibiotic activity against anaerobic bacteria." [PMID:18220342, PMID:1863621] is_a: ARO:3004115 ! nitroimidazole antibiotic xref: pubchem.compound:28061 [Term] id: ARO:3007115 name: modification to cell morphology namespace: antibiotic_resistance def: "Antibiotic-induced changes to cell morphology, including shape, volume and surface area, which decrease antibiotic susceptibility." [PMID:35616332] is_a: ARO:1000002 ! mechanism of antibiotic resistance [Term] id: ARO:3007116 name: Reduction in surface-to-volume ratio of cell namespace: antibiotic_resistance def: "Changes to cell morphology by activated growth response in the presence of an antibiotic, leading to a decreased surface-to-volume ratio. Such changes decrease antibiotic influx and increase antibiotic dilution in the cell, thereby increasing survivability, particularly in nutrient-poor environments." [PMID:35616332] is_a: ARO:3007115 ! modification to cell morphology [Term] id: ARO:3007117 name: subclass B1 Bacteroides xylanisolvens crx beta-lactamase namespace: antibiotic_resistance def: "Subclass B1 Bacteroides xylanisolvens crx beta-lactamases are zinc metallo-beta-lactamases that hydrolyze carbapenems." [PMID:35296904] is_a: ARO:3000568 ! subclass B1 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3007118 name: crxA namespace: antibiotic_resistance def: "crxA is a subclass B1 metallo-betal-lactamase from Bacteroides xylanisolvens that hydrolyzes carbapenems such as imipenem and meropenem." [PMID:35296904] is_a: ARO:3007117 ! subclass B1 Bacteroides xylanisolvens crx beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem synonym: "crxA" EXACT CARD_Short_Name [] [Term] id: ARO:3007119 name: tet(O/32/O) namespace: antibiotic_resistance def: "Tet(O/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein." [PMID:11600392] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(O/32/O)" EXACT CARD_Short_Name [] [Term] id: ARO:3007120 name: tet(O/M/O) namespace: antibiotic_resistance def: "Tet(O/M/O) is a mosaic tetracycline resistance gene and ribosomal protection protein." [PMID:15470128] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(O/M/O)" EXACT CARD_Short_Name [] [Term] id: ARO:3007121 name: tet(O/W) namespace: antibiotic_resistance def: "Tet(O/W) is a mosaic tetracycline resistance gene and ribosomal protection protein." [PMID:15184185] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(O/W)" EXACT CARD_Short_Name [] [Term] id: ARO:3007122 name: tet(O/W/32/O) namespace: antibiotic_resistance def: "Tet(O/W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein." [PMID:17967912] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(O/W/32/O)" EXACT CARD_Short_Name [] [Term] id: ARO:3007123 name: tet(O/W/O) namespace: antibiotic_resistance def: "Tet(O/W/O) is a mosaic tetracycline resistance gene and ribosomal protection protein." [PMID:12839756] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(O/W/O)" EXACT CARD_Short_Name [] [Term] id: ARO:3007124 name: tet(W/32/O) namespace: antibiotic_resistance def: "Tet(W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein." [PMID:11959557] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(W/32/O)" EXACT CARD_Short_Name [] [Term] id: ARO:3007125 name: ROB-11 namespace: antibiotic_resistance def: "ROB-11 is a class A beta-lactamase from the blaROB AMR gene family." [] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-11" EXACT CARD_Short_Name [] [Term] id: ARO:3007126 name: ROB-12 namespace: antibiotic_resistance def: "ROB-12 is a class A beta-lactamase from the blaROB AMR gene family." [] is_a: ARO:3002994 ! ROB beta-lactamase synonym: "ROB-12" EXACT CARD_Short_Name [] [Term] id: ARO:3007127 name: Streptomyces lividans otr(A) namespace: antibiotic_resistance def: "Streptomyces lividans otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces lividans." [PMID:1510403] is_a: ARO:0000002 ! tetracycline-resistant ribosomal protection protein relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "otr(A)S.liv" EXACT CARD_Short_Name [] synonym: "tet" EXACT [] [Term] id: ARO:3007128 name: serine beta-lactamase inhibitor namespace: antibiotic_resistance def: "Serine beta-lactamase inhibitors are molecules that inhibit the function of Ambler class A, C, and D beta-lactamases, preventing the inactivation of beta-lactam antibiotics by these enzymes." [] is_a: ARO:3000042 ! beta-lactamase inhibitor [Term] id: ARO:3007129 name: metallo-beta-lactamase inhibitor namespace: antibiotic_resistance def: "Metallo-beta-lactamase inhibitors are molecules that inhibit the function of Ambler class B (metallo-) beta-lactamases, preventing the inactivation of beta-lactam antibiotics by these enzymes." [] is_a: ARO:3000042 ! beta-lactamase inhibitor [Term] id: ARO:3007130 name: beta-lactam derived beta-lactamase inhibitor namespace: antibiotic_resistance def: "Beta-lactam derived beta-lactamase inhibitors are molecules possessing structural similarity to beta-lactam antibiotics (i.e. beta-lactam ring) that inhibit the function of serine beta-lactamases." [] is_a: ARO:3007128 ! serine beta-lactamase inhibitor [Term] id: ARO:3007131 name: boronic acid beta-lactamase inhibitor namespace: antibiotic_resistance def: "A class of serine beta-lactamase inhibitors." [] is_a: ARO:3007128 ! serine beta-lactamase inhibitor [Term] id: ARO:3007132 name: unclassified serine beta-lactamase inhibitor namespace: antibiotic_resistance def: "Serine beta-lactamase inhibitors with unknown or undefined classification." [] is_a: ARO:3007128 ! serine beta-lactamase inhibitor [Term] id: ARO:3007133 name: polypyridine metallo-beta-lactamase inhibitor namespace: antibiotic_resistance def: "A class of metallo-beta-lactamase inhibitors." [] is_a: ARO:3007129 ! metallo-beta-lactamase inhibitor [Term] id: ARO:3007134 name: phosphonate metallo-beta-lactamase inhibitor namespace: antibiotic_resistance def: "A class of metallo-beta-lactamase inhibitors." [] is_a: ARO:3007129 ! metallo-beta-lactamase inhibitor [Term] id: ARO:3007135 name: bisthiazolidine metallo-beta-lactamase inhibitor namespace: antibiotic_resistance def: "A class of metallo-beta-lactamase inhibitors." [] is_a: ARO:3007129 ! metallo-beta-lactamase inhibitor [Term] id: ARO:3007136 name: unclassified metallo-beta-lactamase inhibitor namespace: antibiotic_resistance def: "Metallo-beta-lactamase inhibitors with unknown or undefined classification." [] is_a: ARO:3007129 ! metallo-beta-lactamase inhibitor [Term] id: ARO:3007137 name: mcr-10.1 namespace: antibiotic_resistance def: "An MCR-10-type colistin resistance gene variant." [PMID:35695522] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "mcr-10.1" EXACT CARD_Short_Name [] [Term] id: ARO:3007138 name: S02030 namespace: antibiotic_resistance def: "S02030 is an experimental metallo-beta-lactamase inhibitor that exhibits activity against MOX-1." [PMID:34970229] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3002182 ! MOX-1 synonym: "1-{(2r)-2-(Dihydroxyboranyl)-2-[(Thiophen-2-Ylacetyl)amino]ethyl}-1h-1,2,3-Triazole-4-Carboxylic Acid" EXACT [] xref: pubchem.compound:71519576 [Term] id: ARO:3007139 name: cordycepin namespace: antibiotic_resistance def: "Cordycepin is an experimental nucleoside antibiotic which has been shown to exhibit activity against H. pylori. It is produced by the Cordyceps fungus, which is used in traditional Chinese medicine." [PMID:35191475] is_a: ARO:3000034 ! nucleoside antibiotic synonym: "3'-deoxyadenosine" EXACT [] synonym: "cordycepine" EXACT [] xref: pubchem.compound:6303 [Term] id: ARO:3007140 name: unithiol namespace: antibiotic_resistance def: "Unithiol is an experimental chelating agent that forms complexes with heavy metals. It has been shown to inhibit the action of the metallo-beta-lactamases NDM-1 and VIM-2." [PMID:35163756] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002272 ! VIM-2 synonym: "DMPS" EXACT [] xref: pubchem.compound:2724039 [Term] id: ARO:3007141 name: BLI-489 namespace: antibiotic_resistance def: "BLI-489 is an experimental beta-lactamase inhibitor that exhibits broad spectrum activity against class A, B, and D carbapenemases." [PMID:35165715] is_a: ARO:3007130 ! beta-lactam derived beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000467 ! NDM-5 relationship: is_small_molecule_inhibitor ARO:3001418 ! OXA-23 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 xref: pubchem.compound:9972353 [Term] id: ARO:3007142 name: plantacirin A namespace: antibiotic_resistance def: "Plantacirin A is a short cationic bacteriocin that increases permeability of the bacterial outer membrane, thus enhancing the effect of accompanying antibiotics. It is derived from Lactiplantibacillus plantarum." [PMID:35499329] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry synonym: "PlnA" EXACT [] [Term] id: ARO:3007143 name: sulopenem namespace: antibiotic_resistance def: "Sulopenem is a carbapenem derivative in phase III clinical trials (2022) for the treatment of various gram-positive and gram-negative infections." [PMID:35294769] is_a: ARO:0000020 ! carbapenem xref: pubchem.compound:9950244 [Term] id: ARO:3007144 name: PBT2 namespace: antibiotic_resistance def: "PBT2 is a former Alzheimer's and Huntington's disease candidate drug that has since been shown to increase susceptibility to colistin, polymyxin B, and tetracycline in N. gonorrhoeae. It is thought to inactivate lipooligosaccharide phosphoethanolamine transferase A, resulting in alteration of cell membrane charge." [PMID:34450628] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:10016012 [Term] id: ARO:3007145 name: imipenem-cilastatin-relebactam namespace: antibiotic_resistance def: "An antibiotic-adjuvant admixture of the beta-lactam antibiotic imipenem, beta-lactam potentiator cilastatin, and beta-lactamase inhibitor relebactam." [PMID:29230684, PMID:33580649] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000170 ! imipenem relationship: has_part ARO:3007031 ! relebactam relationship: has_part ARO:3007063 ! cilastatin [Term] id: ARO:3007146 name: meropenem-vaborbactam namespace: antibiotic_resistance def: "An antibiotic-adjuvant admixture of the beta-lactam antibiotic meropenem and the beta-lactamase inhibitor vaborbactam." [PMID:29692218, PMID:29230684] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000073 ! meropenem relationship: has_part ARO:3004380 ! vaborbactam synonym: "Carbavance" EXACT [] synonym: "Vabomere" EXACT [] xref: pubchem.compound:86298703 [Term] id: ARO:3007147 name: taniborbactam namespace: antibiotic_resistance def: "Taniborbactam is a broad-spectrum beta-lactamase inhibitor. As of 2022, it is in phase III clinical trials in combination with cefepime and is the only beta-lactamase inhibitor exhibiting activity against all four classes of beta-lactamase." [PMID:31871094] is_a: ARO:3007131 ! boronic acid beta-lactamase inhibitor is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000590 ! NDM-2 relationship: is_small_molecule_inhibitor ARO:3001064 ! SHV-5 relationship: is_small_molecule_inhibitor ARO:3001396 ! OXA-1 relationship: is_small_molecule_inhibitor ARO:3001782 ! OXA-48 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3002013 ! CMY-2 relationship: is_small_molecule_inhibitor ARO:3002192 ! IMP-1 relationship: is_small_molecule_inhibitor ARO:3002272 ! VIM-2 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 synonym: "VNRX-5133" EXACT [] xref: pubchem.compound:76902493 [Term] id: ARO:3007148 name: cefepime-taniborbactam namespace: antibiotic_resistance def: "An antibiotic cocktail containing the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor taniborbactam. As of 2022, this antibiotic-adjuvant mixture is in phase III clinical trials for the treatment of various bacterial infections." [PMID:31871094] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000059 ! cefepime relationship: has_part ARO:3007147 ! taniborbactam [Term] id: ARO:3007149 name: phosphonic acid antibiotic namespace: antibiotic_resistance def: "A group of antibiotics derived from phosphonic acids." [PMID:5809587, PMID:10477522] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007150 name: bicyclomycin-like antibiotic namespace: antibiotic_resistance def: "A group of antibiotics including bicyclomycin and its analogues." [PMID:7487110] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007151 name: mupirocin-like antibiotic namespace: antibiotic_resistance def: "A group of antibiotics including mupirocin and similar mixtures (such as those including pseudomonic acid A)." [PMID:21336932] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007152 name: isoniazid-like antibiotic namespace: antibiotic_resistance def: "A group of antibiotics containing isoniazid and its derivatives." [PMID:8143118] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007153 name: fusidane antibiotic namespace: antibiotic_resistance def: "A group of antibiotics possessing steroid rings or steroid-like structures." [PMID:32915993] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007154 name: cycloserine-like antibiotic namespace: antibiotic_resistance def: "A group of antibiotics including cycloserine and its derivatives." [PMID:4555420] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007155 name: pyrazine antibiotic namespace: antibiotic_resistance def: "A group of antibiotics derived from pyrazine." [PMID:26104205] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007156 name: thioamide antibiotic namespace: antibiotic_resistance def: "A group of antibiotics possessing the thioamide functional group." [PMID:26586647] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007157 name: nybomycin-like antibiotic namespace: antibiotic_resistance def: "A group of antibiotics including nybomycin and its derivatives." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007158 name: pactamycin-like antibiotic namespace: antibiotic_resistance def: "A group of antibiotics including pactamycin and its derivatives." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007159 name: salicylic acid antibiotic namespace: antibiotic_resistance def: "A group of antibiotics derived from salicylic acid." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007160 name: zoliflodacin-like antibiotic namespace: antibiotic_resistance def: "A group of antibiotics including the experimental compound zoliflodacin and its derivatives." [PMID:31730160] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007161 name: thiosemicarbazone antibiotic namespace: antibiotic_resistance def: "A group of antibiotics derived from thiosemicarbazide (possessing the thiosemicarbazone functional group)." [PMID:33022959, PMID:18094751] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007162 name: protegrin-1-like antibiotic namespace: antibiotic_resistance def: "A group of peptidomimetic antibiotics based on the peptide protegrin-1." [PMID:20167788] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007163 name: albendazole-like antibiotic namespace: antibiotic_resistance def: "A group of antibiotics including albendazole and similar antiparasitic compounds that exhibit antibacterial activity." [PMID:35453279] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007164 name: triazaacenaphthylene antibiotic namespace: antibiotic_resistance def: "A group of antibiotics derived from triazaacenaphthylene." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007165 name: gemifloxacin namespace: antibiotic_resistance def: "Gemifloxacin is a broad-spectrum, fourth generation, oral fluoroquinolone antibiotic used in the treatment of various bacterial infections, primarily in the lungs. It has been discontinued for therapeutic use in the US over concerns of tendon and peripheral neuron toxicity, although it is still available for experimental application and elsewhere for therapeutic use. It is usually administered as a mesylate salt, gemifloxacin mesylate." [PMID:12764426] is_a: ARO:0000001 ! fluoroquinolone antibiotic synonym: "Factive" EXACT [] xref: pubchem.compound:9571107 [Term] id: ARO:3007166 name: orthosomycin antibiotic namespace: antibiotic_resistance def: "Orthosomycins are a group of experimental/veterinary orthoester and oligosaccharide antibiotics that target the 70s ribosomal subunit. They are generally no longer considered potential clinical antibiotics, but continue to be used in livestock feed and for experimental purposes." [PMID:27330110] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007167 name: evernimicin namespace: antibiotic_resistance def: "Evernimicin is a veterinary oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with avilamycin, it exhibits activity against a variety of Gram-positive and -negative bacteria and is primarily used in livestock feed." [PMID:27330110] is_a: ARO:3007166 ! orthosomycin antibiotic synonym: "everninomicin" EXACT [] xref: pubchem.compound:6917933 [Term] id: ARO:3007168 name: avalimycin namespace: antibiotic_resistance def: "Avilamycin is an experimental oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with evernimicin, it exhibits activity against a variety of Gram-positive and -negative bacteria." [PMID:27330110] is_a: ARO:3007166 ! orthosomycin antibiotic xref: pubchem.compound:76959299 [Term] id: ARO:3007169 name: pirlimycin namespace: antibiotic_resistance def: "Pirlimycin is an experimental/veterinary lincosamide antibiotic. Although not approved for use in humans, pirlimycin is commonly used to treat mammary gland infections in cattle." [PMID:12584673] is_a: ARO:0000017 ! lincosamide antibiotic synonym: "Pirsue" EXACT [] xref: pubchem.compound:157385 [Term] id: ARO:3007171 name: enmetazobactam namespace: antibiotic_resistance def: "Enmetazobactam is a beta-lactamase inhibitor which exhibits activity against class A extended spectrum beta-lactamases. It is currently in clinical trials in combination with cefepine for the treatment of urinary tract infections and acute pyelonephritis." [PMID:32253212, PMID:35486701] is_a: ARO:3007130 ! beta-lactam derived beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000979 ! TEM-116 relationship: is_small_molecule_inhibitor ARO:3001405 ! OXA-10 xref: pubchem.compound:23653540 [Term] id: ARO:3007172 name: methimazole namespace: antibiotic_resistance def: "Methimazole is thiamide usually used to treat hyperthyroidism. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem." [PMID:35197545] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 synonym: "Tapazole" EXACT [] synonym: "thiamazole" EXACT [] xref: pubchem.compound:1349907 [Term] id: ARO:3007173 name: lipoic acid namespace: antibiotic_resistance def: "Lipoic acid is a compound used for diabetic neuropathy and as a nutritional supplement. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem." [PMID:35197545] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 synonym: "alpha-lipoic acid" EXACT [] xref: pubchem.compound:864 [Term] id: ARO:3007174 name: scutellarin namespace: antibiotic_resistance def: "Scutellarin is an experimental antibiotic potentiator that inhibits bacterial sortase A and caseinolytic peptidase P. When used in combination with vancomycin against methicillin-resistant Staphylococcus aureus, scutellarin improves activity of the antibiotic, making it an effective adjuvant in the treatment of such infections." [PMID:35247333] is_a: ARO:3007222 ! inhibitor of antibiotic resistance mechanism xref: pubchem.compound:185617 [Term] id: ARO:3007175 name: TP0586532 namespace: antibiotic_resistance def: "TP0586532 is an antibiotic potentiator that acts by inhibiting bacterial LpxC, interfering with the production of lipopolysaccharides. It has been shown to increase the effects of several antibiotics, such as meropenem, amikacin, cefepime, and tigecycline. The disruption of lipopolysaccharide synthesis is suspected to lead to increased membrane permeability." [PMID:35647694] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:155294517 [Term] id: ARO:3007176 name: TNP-2198 namespace: antibiotic_resistance def: "TNP-2198 is an experimental rifamycin-nitroimidazole conjugate currently in development for treatment of several bacterial infections. It exhibits greater activity than rifamycin and nitroimidazole antibiotics administered together and is effective against bacteria resistant to both drug classes." [PMID:35175750] is_a: ARO:3000157 ! rifamycin antibiotic is_a: ARO:3004115 ! nitroimidazole antibiotic xref: pubchem.compound:136014272 [Term] id: ARO:3007177 name: thiazolide antibiotic namespace: antibiotic_resistance def: "Antibiotics belonging to the thiazolide group. Note that many thiazolides are used as antiviral compounds, however some have also exhibited antibacterial activity." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007178 name: nitazoxanide namespace: antibiotic_resistance def: "Nitazoxanide is a thiazolide antiparatasitic and antiviral drug that has demonstrated antibacterial activity against Helicobacter pylori. It is well tolerated and exhibits a synergistic effect with other antibiotics, such as clarithromycin." [PMID:35587063] is_a: ARO:3007177 ! thiazolide antibiotic synonym: "Alinia" EXACT [] synonym: "Nizonide" EXACT [] synonym: "nitazoxamide" EXACT [] xref: pubchem.compound:41684 [Term] id: ARO:3007179 name: class A Mycobacterium abscessus beta-lactamase namespace: antibiotic_resistance def: "Class A beta-lactamse from M. abscessus." [PMID:28096155, PMID:24132992] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3007180 name: MAB namespace: antibiotic_resistance def: "MAB is a broad-spectrum class A beta-lactamase produced by Mycobacterium abscessus that has been shown to hydrolyze a large number of beta-lactam antibiotics." [PMID:24132992, PMID:28096155] is_a: ARO:3007179 ! class A Mycobacterium abscessus beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "MAB" EXACT CARD_Short_Name [] [Term] id: ARO:3007181 name: class A Mycobacterium tuberculosis bla beta-lactamase namespace: antibiotic_resistance def: "Class A beta-lactamase from M. tuberculosis." [PMID:20353175, PMID:24132992] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam relationship: confers_resistance_to_drug_class ARO:3003706 ! penem [Term] id: ARO:3007182 name: blaC namespace: antibiotic_resistance def: "blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs." [PMID:24132992, PMID:20353175] is_a: ARO:3007181 ! class A Mycobacterium tuberculosis bla beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3003831 ! temocillin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin synonym: "blaC" EXACT CARD_Short_Name [] [Term] id: ARO:3007183 name: antibiotic resistant Rv1258c namespace: antibiotic_resistance def: "Mutations in the Rv1258c (Tap) efflux pump contributing to antibiotic resistance." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3007184 name: multidrug resistant Rv1258c namespace: antibiotic_resistance def: "Mutations in the Rv1258c efflux pump contributing to resistance to multiple antibiotics." [PMID:35158297, PMID:30837962] is_a: ARO:3007183 ! antibiotic resistant Rv1258c relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic relationship: confers_resistance_to_drug_class ARO:3000527 ! polyamine antibiotic relationship: confers_resistance_to_drug_class ARO:3007152 ! isoniazid-like antibiotic relationship: confers_resistance_to_drug_class ARO:3007155 ! pyrazine antibiotic [Term] id: ARO:3007185 name: Mycobacterium tuberculosis Rv1258c mutations confer resistance to ethambutol and capreomycin namespace: antibiotic_resistance def: "Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to multiple ethambutol and capreomycin." [PMID:35158297] is_a: ARO:3007184 ! multidrug resistant Rv1258c relationship: confers_resistance_to_antibiotic ARO:3000497 ! ethambutol relationship: confers_resistance_to_antibiotic ARO:3003993 ! capreomycin synonym: "Mtub_tap_EMCM" EXACT CARD_Short_Name [] [Term] id: ARO:3007186 name: Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin namespace: antibiotic_resistance def: "Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to pyrazinamide, isoniazid, and streptomycin." [PMID:30837962] is_a: ARO:3007184 ! multidrug resistant Rv1258c relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid relationship: confers_resistance_to_antibiotic ARO:3003413 ! pyrazinamide synonym: "Mtub_tap_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3007187 name: glycopeptide resistance gene cluster vanP namespace: antibiotic_resistance def: "This cluster confers resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Resistance is acquired after multiple treatments with sub-minimum inhibitory concentrations of vancomycin. Gene orientation: vanHPXRS." [PMID:34505571] is_a: ARO:3000234 ! glycopeptide resistance gene cluster relationship: confers_resistance_to_antibiotic ARO:0000028 ! vancomycin relationship: confers_resistance_to_antibiotic ARO:0000029 ! teicoplanin synonym: "vanP_cluster" EXACT CARD_Short_Name [] [Term] id: ARO:3007188 name: vanH gene in vanP cluster namespace: antibiotic_resistance def: "vanH variant in the vanP cluster." [PMID:34505571] is_a: ARO:3000006 ! vanH relationship: part_of ARO:3007187 ! glycopeptide resistance gene cluster vanP synonym: "vanH-P" EXACT [] synonym: "vanHP" EXACT [] synonym: "vanH_in_vanP_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3007189 name: vanP namespace: antibiotic_resistance def: "vanP is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance." [PMID:34505571] is_a: ARO:3002978 ! D-Ala-D-Lac ligase relationship: part_of ARO:3007187 ! glycopeptide resistance gene cluster vanP synonym: "vanP" EXACT CARD_Short_Name [] [Term] id: ARO:3007190 name: vanX gene in vanP cluster namespace: antibiotic_resistance def: "vanX variant in the vanP cluster." [PMID:34505571] is_a: ARO:3000011 ! vanX relationship: part_of ARO:3007187 ! glycopeptide resistance gene cluster vanP synonym: "vanX-P" EXACT [] synonym: "vanXP" EXACT [] synonym: "vanX_in_vanP_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3007191 name: vanR gene in vanP cluster namespace: antibiotic_resistance def: "vanR variant in the vanP cluster." [PMID:34505571] is_a: ARO:3000574 ! vanR relationship: part_of ARO:3007187 ! glycopeptide resistance gene cluster vanP synonym: "vanR-P" EXACT [] synonym: "vanRP" EXACT [] synonym: "vanR_in_vanP_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3007192 name: vanS gene in vanP cluster namespace: antibiotic_resistance def: "vanS variant in the vanP cluster." [PMID:34505571] is_a: ARO:3000071 ! vanS relationship: part_of ARO:3007187 ! glycopeptide resistance gene cluster vanP synonym: "vanS-P" EXACT [] synonym: "vanSP" EXACT [] synonym: "vanS_in_vanP_cl" EXACT CARD_Short_Name [] [Term] id: ARO:3007193 name: National Committee for Clinical Laboratory Standards (NCCLS) namespace: antibiotic_resistance def: "The National Committee for Clinical Laboratory Standards is an American organization responsible for developing accredited consensus clinical laboratory standards." [PMID:11977864] is_a: ARO:3004360 ! antimicrobial resistance testing reference standard [Term] id: ARO:3007194 name: antimicrobial resistance surveillance systems namespace: antibiotic_resistance def: "Groups, organizations, and government bodies dedicated to the surveillance of antimicrobial resistance." [] is_a: ARO:3000045 ! component of AMR genotypic or phenotypic terminology [Term] id: ARO:3007195 name: National Antimicrobial Resistance Monitoring System (NARMS) namespace: antibiotic_resistance def: "The National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) is a US public health surveillance system that tracks antimicrobial resistance in foodborne and other enteric bacteria." [PMID:17927472] is_a: ARO:3007194 ! antimicrobial resistance surveillance systems [Term] id: ARO:3007196 name: KPC-123 namespace: antibiotic_resistance def: "KPC-123 is a KPC beta-lactamase." [PMID:35794918] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime synonym: "KPC-123" EXACT CARD_Short_Name [] [Term] id: ARO:3007197 name: enramycin namespace: antibiotic_resistance def: "Enramycin is a polypeptide antibiotic commonly used as a feed additive for livestock. It is produced by species of the Streptomyces genus and is used to prevent necrotic enteritis in poultry and pigs. Enramycin disrupts cell wall synthesis by inhibiting MurG." [PMID:35841645] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:56842192 [Term] id: ARO:3007198 name: PAM beta-lactamase namespace: antibiotic_resistance def: "A family of subclass B3 metallo-beta-lactamases discovered in Pseudomonas alcaligenes and found in other members of the Pseudomonas genus. PAM beta-lactamases hydrolyze cephalosporins and carbenems." [PMID:33577996, PMID:24356301] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3007199 name: PAM-1 namespace: antibiotic_resistance def: "PAM-1 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Psuedomonas genus." [PMID:24356301] is_a: ARO:3007198 ! PAM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:3000640 ! doripenem synonym: "PAM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007200 name: PAM-2 namespace: antibiotic_resistance def: "PAM-2 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus." [PMID:33577996] is_a: ARO:3007198 ! PAM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "PAM-2" EXACT CARD_Short_Name [] [Term] id: ARO:3007201 name: PAM-3 namespace: antibiotic_resistance def: "PAM-3 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus. The sequence of PAM-3 was made available through NCBI's Reference Gene Catalogue." [] is_a: ARO:3007198 ! PAM beta-lactamase synonym: "PAM-3" EXACT CARD_Short_Name [] [Term] id: ARO:3007202 name: NDM-16b namespace: antibiotic_resistance def: "New Delhi class B metallo-beta-lactamase 16b variant." [PMID:35867355] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-16b" EXACT CARD_Short_Name [] [Term] id: ARO:3007203 name: Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin namespace: antibiotic_resistance def: "Mutations in Klebsiella pneumoniae PhoQ of the two-component PhoPQ regulatory system conferring resistance to colistin." [PMID:35920875] is_a: ARO:3000835 ! phoQ relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "Kpne_PhoQ_CST" EXACT CARD_Short_Name [] [Term] id: ARO:3007204 name: AAC(6')-Iap namespace: antibiotic_resistance def: "AAC(6')-Iap is an aminoglycoside acetyltransferase that confers resistance to a number of aminoglycoside antibiotics." [PMID:35862995] is_a: ARO:3007395 ! AAC(6')-I relationship: confers_resistance_to_antibiotic ARO:0000007 ! dibekacin relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin relationship: confers_resistance_to_antibiotic ARO:0000035 ! sisomicin relationship: confers_resistance_to_antibiotic ARO:0000038 ! netilmicin relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3007378 ! 2'-N-ethylnetilmicin relationship: confers_resistance_to_antibiotic ARO:3007379 ! 5-episisomicin synonym: "AAC(6')-Iap" EXACT CARD_Short_Name [] [Term] id: ARO:3007205 name: KBL beta-lactamase namespace: antibiotic_resistance def: "Kathmandu beta-lactamases are a group of class A beta-lactamases that hydrolyze penicillin antibiotics." [PMID:35862995] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007206 name: KBL-1 namespace: antibiotic_resistance def: "KBL-1 is a KBL class A beta-lactamase that confers resistance to a number of penicillin antibiotics." [PMID:35862995] is_a: ARO:3007205 ! KBL beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "KBL-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007207 name: helicase-like RNA polymerase protection protein namespace: antibiotic_resistance def: "Helicase-like proteins that confer resistance to antibiotics such as rifamycins by preventing or disrupting their binding to RNA polymerase." [PMID:35907401] is_a: ARO:3000507 ! rifampin-resistant RNA polymerase-binding protein relationship: confers_resistance_to_drug_class ARO:3000157 ! rifamycin antibiotic [Term] id: ARO:3007208 name: HelR namespace: antibiotic_resistance def: "HelR is a helicase-like protein that confers resistance to rifamycins by displacing them from the RNA polymerase complex. The protein forces the antibiotic away from the polymerase by binding in its place. It then ejects itself from the complex, allowing the polymerase to resume normal function." [PMID:35907401] is_a: ARO:3007207 ! helicase-like RNA polymerase protection protein relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000530 ! rifabutin synonym: "HelR" EXACT CARD_Short_Name [] [Term] id: ARO:3007209 name: Streptomyces venezuelae rox namespace: antibiotic_resistance def: "Streptomyces venezuelae rox is a class A flavoprotein monooxygenase that confers resistance to rifamycin antibiotics. It acts by oxygenating the naphthyl group of the antibiotic, leading to a ring opening event and linearization of the molecule." [PMID:29398560] is_a: ARO:3000445 ! rifampin monooxygenase relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin relationship: confers_resistance_to_antibiotic ARO:3000517 ! rifaximin relationship: confers_resistance_to_antibiotic ARO:3000534 ! rifapentine synonym: "Rox-sv" EXACT [] synonym: "Sven_rox" EXACT CARD_Short_Name [] [Term] id: ARO:3007210 name: Nocardia farcinica rox namespace: antibiotic_resistance def: "Nocardia farcinica rox is a rifampin monooxygenase that inactivates rifampin." [PMID:19942945] is_a: ARO:3000445 ! rifampin monooxygenase relationship: confers_resistance_to_antibiotic ARO:3000169 ! rifampin synonym: "Nfar_rox" EXACT CARD_Short_Name [] synonym: "Rox-nf" EXACT [] [Term] id: ARO:3007211 name: NDM-34 namespace: antibiotic_resistance def: "NDM-34 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-34" EXACT CARD_Short_Name [] [Term] id: ARO:3007212 name: NDM-35 namespace: antibiotic_resistance def: "NDM-35 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-35" EXACT CARD_Short_Name [] [Term] id: ARO:3007213 name: NDM-36 namespace: antibiotic_resistance def: "NDM-36 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-36" EXACT CARD_Short_Name [] [Term] id: ARO:3007214 name: NDM-37 namespace: antibiotic_resistance def: "NDM-37 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-37" EXACT CARD_Short_Name [] [Term] id: ARO:3007215 name: NDM-38 namespace: antibiotic_resistance def: "NDM-38 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-38" EXACT CARD_Short_Name [] [Term] id: ARO:3007216 name: NDM-39 namespace: antibiotic_resistance def: "NDM-39 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-39" EXACT CARD_Short_Name [] [Term] id: ARO:3007217 name: NDM-40 namespace: antibiotic_resistance def: "NDM-40 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-40" EXACT CARD_Short_Name [] [Term] id: ARO:3007218 name: NDM-41 namespace: antibiotic_resistance def: "NDM-41 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-41" EXACT CARD_Short_Name [] [Term] id: ARO:3007219 name: NDM-42 namespace: antibiotic_resistance def: "NDM-42 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-42" EXACT CARD_Short_Name [] [Term] id: ARO:3007220 name: NDM-43 namespace: antibiotic_resistance def: "NDM-43 is a NDM beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-43" EXACT CARD_Short_Name [] [Term] id: ARO:3007221 name: trispicenA namespace: antibiotic_resistance def: "An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor." [PMID:33285370] is_a: ARO:3007133 ! polypyridine metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000582 ! L1 beta-lactamase relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002272 ! VIM-2 synonym: "N,N,N'-tris(2-pyridylmethyl)-ethylenediamine-N'-acetic acid" EXACT [] [Term] id: ARO:3007222 name: inhibitor of antibiotic resistance mechanism namespace: antibiotic_resistance def: "A class of antibiotic adjuvant in which the adjuvant directly or indirectly inhibits the mechanism of resistance, restoring antibiotic susceptibility or decreasing the minimum inhibitory concentration." [] is_a: ARO:0000076 ! resistance-modifying agents [Term] id: ARO:3007223 name: adjuvants enhancing antibiotic entry namespace: antibiotic_resistance def: "A class of antibiotic adjuvants which enhance the antibiotic capability to enter the cell through passive or active membrane transport." [] is_a: ARO:0000076 ! resistance-modifying agents [Term] id: ARO:3007224 name: adjuvants inhibiting antibiotic removal namespace: antibiotic_resistance def: "A class of adjuvants which inhibit or prevent the cellular removal of an antibiotic through mechanisms including antibiotic efflux." [] is_a: ARO:0000076 ! resistance-modifying agents [Term] id: ARO:3007225 name: adjuvants which alter physiology namespace: antibiotic_resistance def: "A class of antibiotic adjuvants which indirectly increase antibiotic susceptibility through alterations to cellular physiology, for example those adjuvants which inhibit biofilm formation." [] is_a: ARO:0000076 ! resistance-modifying agents [Term] id: ARO:3007226 name: host-related antibiotic adjuvants namespace: antibiotic_resistance def: "A class of antibiotic adjuvants which indirectly improve antibiotic susceptibility or retention through alterations to host physiology or metabolism." [] is_a: ARO:0000076 ! resistance-modifying agents [Term] id: NCIT:23014 name: gram stain namespace: antibiotic_resistance def: "Gram staining is a method for staining and identifying bacteria. It is based on the differential retention of a crystal violet-iodine complex within the cell membrane. The cell wall of gram-positive cells have a thick peptidoglycan layer that retains crystal violet after an alcohol wash (staining black-blue or purple by a counterstain). The cell wall of gram-negative cells have a thinner peptidoglycan layer that does not retain crystal violet after an alcohol wash (staining red after counterstain). Some cells have variable staining in culture (e.g. Bacillus, Clostridium) while others have indeterminate staining due to unique aspects of their cell membrane or wall (e.g. Mycobacterium, Mycoplasma)." [PMID:19885931] is_a: ARO:3004389 ! reagent or protocol used for testing AMR [Term] id: ARO:3007227 name: MCR-8.3 namespace: antibiotic_resistance def: "An MCR-8-type colistin resistance gene variant." [PMID:31849875] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-8.3" EXACT CARD_Short_Name [] [Term] id: ARO:3007228 name: MCR-8.4 namespace: antibiotic_resistance def: "An MCR-8-type colistin resistance gene variant." [PMID:30828324] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-8.4" EXACT CARD_Short_Name [] [Term] id: ARO:3007229 name: MCR-8.2 namespace: antibiotic_resistance def: "An MCR-8-type colistin resistance gene variant." [PMID:30864883] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-8.2" EXACT CARD_Short_Name [] [Term] id: ARO:3007230 name: MCR-1.34 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.34" EXACT CARD_Short_Name [] [Term] id: ARO:3007231 name: MCR-4.6 namespace: antibiotic_resistance def: "An MCR-4-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-4.6" EXACT CARD_Short_Name [] [Term] id: ARO:3007232 name: MCR-1.27 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.27" EXACT CARD_Short_Name [] [Term] id: ARO:3007233 name: MCR-1.18 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.18" EXACT CARD_Short_Name [] [Term] id: ARO:3007234 name: MCR-1.23 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.23" EXACT CARD_Short_Name [] [Term] id: ARO:3007235 name: MCR-1.20 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.20" EXACT CARD_Short_Name [] [Term] id: ARO:3007236 name: MCR-1.28 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.28" EXACT CARD_Short_Name [] [Term] id: ARO:3007237 name: MCR-1.21 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.21" EXACT CARD_Short_Name [] [Term] id: ARO:3007238 name: MCR-1.16 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.16" EXACT CARD_Short_Name [] [Term] id: ARO:3007239 name: MCR-1.22 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [PMID:34091039] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.22" EXACT CARD_Short_Name [] [Term] id: ARO:3007240 name: MCR-1.19 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.19" EXACT CARD_Short_Name [] [Term] id: ARO:3007241 name: MCR-1.29 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.29" EXACT CARD_Short_Name [] [Term] id: ARO:3007242 name: MCR-1.30 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.30" EXACT CARD_Short_Name [] [Term] id: ARO:3007243 name: MCR-1.24 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.24" EXACT CARD_Short_Name [] [Term] id: ARO:3007244 name: MCR-1.17 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.17" EXACT CARD_Short_Name [] [Term] id: ARO:3007245 name: MCR-1.31 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.31" EXACT CARD_Short_Name [] [Term] id: ARO:3007246 name: MCR-1.14 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.14" EXACT CARD_Short_Name [] [Term] id: ARO:3007247 name: MCR-1.25 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.25" EXACT CARD_Short_Name [] [Term] id: ARO:3007248 name: MCR-3.33 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [PMID:34187559] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.33" EXACT CARD_Short_Name [] [Term] id: ARO:3007249 name: MCR-3.14 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.14" EXACT CARD_Short_Name [] [Term] id: ARO:3007250 name: MCR-3.37 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [PMID:34187559] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.37" EXACT CARD_Short_Name [] [Term] id: ARO:3007251 name: MCR-3.38 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.38" EXACT CARD_Short_Name [] [Term] id: ARO:3007252 name: MCR-3.15 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.15" EXACT CARD_Short_Name [] [Term] id: ARO:3007253 name: MCR-3.27 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.27" EXACT CARD_Short_Name [] [Term] id: ARO:3007254 name: MCR-3.32 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.32" EXACT CARD_Short_Name [] [Term] id: ARO:3007255 name: MCR-3.31 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.31" EXACT CARD_Short_Name [] [Term] id: ARO:3007256 name: MCR-3.23 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.23" EXACT CARD_Short_Name [] [Term] id: ARO:3007257 name: MCR-3.36 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [PMID:34187559] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.36" EXACT CARD_Short_Name [] [Term] id: ARO:3007258 name: MCR-3.25 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.25" EXACT CARD_Short_Name [] [Term] id: ARO:3007259 name: MCR-3.22 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.22" EXACT CARD_Short_Name [] [Term] id: ARO:3007260 name: MCR-3.16 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.16" EXACT CARD_Short_Name [] [Term] id: ARO:3007261 name: MCR-3.26 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.26" EXACT CARD_Short_Name [] [Term] id: ARO:3007262 name: MCR-3.21 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.21" EXACT CARD_Short_Name [] [Term] id: ARO:3007263 name: MCR-3.18 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.18" EXACT CARD_Short_Name [] [Term] id: ARO:3007264 name: MCR-3.40 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.40" EXACT CARD_Short_Name [] [Term] id: ARO:3007265 name: MCR-3.24 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.24" EXACT CARD_Short_Name [] [Term] id: ARO:3007266 name: MCR-3.20 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.20" EXACT CARD_Short_Name [] [Term] id: ARO:3007267 name: MCR-3.35 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [PMID:34187559] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.35" EXACT CARD_Short_Name [] [Term] id: ARO:3007268 name: MCR-3.34 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [PMID:34187559] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.34" EXACT CARD_Short_Name [] [Term] id: ARO:3007269 name: MCR-3.13 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.13" EXACT CARD_Short_Name [] [Term] id: ARO:3007270 name: MCR-3.28 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.28" EXACT CARD_Short_Name [] [Term] id: ARO:3007271 name: MCR-3.39 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.39" EXACT CARD_Short_Name [] [Term] id: ARO:3007272 name: MCR-3.29 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.29" EXACT CARD_Short_Name [] [Term] id: ARO:3007273 name: MCR-3.19 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.19" EXACT CARD_Short_Name [] [Term] id: ARO:3007274 name: MCR-10.5 namespace: antibiotic_resistance def: "An MCR-10-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-10.5" EXACT CARD_Short_Name [] [Term] id: ARO:3007275 name: MCR-10.3 namespace: antibiotic_resistance def: "An MCR-10-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-10.3" EXACT CARD_Short_Name [] [Term] id: ARO:3007276 name: MCR-10.4 namespace: antibiotic_resistance def: "An MCR-10-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-10.4" EXACT CARD_Short_Name [] [Term] id: ARO:3007277 name: MCR-10.2 namespace: antibiotic_resistance def: "An MCR-10-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-10.2" EXACT CARD_Short_Name [] [Term] id: ARO:3007278 name: MCR-3.17 namespace: antibiotic_resistance def: "An MCR-3-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-3.17" EXACT CARD_Short_Name [] [Term] id: ARO:3007279 name: MCR-1.15 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.15" EXACT CARD_Short_Name [] [Term] id: ARO:3007280 name: MCR-1.26 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.26" EXACT CARD_Short_Name [] [Term] id: ARO:3007281 name: MCR-5.4 namespace: antibiotic_resistance def: "An MCR-5-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-5.4" EXACT CARD_Short_Name [] [Term] id: ARO:3007282 name: MCR-5.3 namespace: antibiotic_resistance def: "An MCR-5-type colistin resistance gene variant." [PMID:30864883] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-5.3" EXACT CARD_Short_Name [] [Term] id: ARO:3007283 name: MCR-2.4 namespace: antibiotic_resistance def: "An MCR-2-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-2.4" EXACT CARD_Short_Name [] [Term] id: ARO:3007284 name: MCR-2.3 namespace: antibiotic_resistance def: "An MCR-2-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-2.3" EXACT CARD_Short_Name [] [Term] id: ARO:3007285 name: MCR-2.8 namespace: antibiotic_resistance def: "An MCR-2-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-2.8" EXACT CARD_Short_Name [] [Term] id: ARO:3007286 name: MCR-2.5 namespace: antibiotic_resistance def: "An MCR-2-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-2.5" EXACT CARD_Short_Name [] [Term] id: ARO:3007287 name: MCR-2.7 namespace: antibiotic_resistance def: "An MCR-2-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-2.7" EXACT CARD_Short_Name [] [Term] id: ARO:3007288 name: MCR-2.6 namespace: antibiotic_resistance def: "An MCR-2-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-2.6" EXACT CARD_Short_Name [] [Term] id: ARO:3007289 name: MCR-1.32 namespace: antibiotic_resistance def: "An MCR-1-type colistin resistance gene variant." [] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-1.32" EXACT CARD_Short_Name [] [Term] id: ARO:3007290 name: fosfomycin thiol transferase inhibitor namespace: antibiotic_resistance def: "Adjuvants shown to inhibit the action of fosfomycin thiol transferases." [PMID:15504029] is_a: ARO:3007222 ! inhibitor of antibiotic resistance mechanism [Term] id: ARO:3007291 name: inhibitor of aminoglycoside inactivation enzyme namespace: antibiotic_resistance def: "Adjuvants shown to inhibit the action of aminoglycoside inactivating enzymes, such as the APH and AAC enzyme families." [PMID:23758273, PMID:22760297] is_a: ARO:3007222 ! inhibitor of antibiotic resistance mechanism [Term] id: ARO:3007292 name: MCR phosphoethanolamine transferase inhibitor namespace: antibiotic_resistance def: "Adjuvants shown to inhibit the action of mobile colistin resistance phosphoethanolamine transferase genes." [PMID:29339386] is_a: ARO:3007222 ! inhibitor of antibiotic resistance mechanism [Term] id: ARO:3007293 name: durlobactam namespace: antibiotic_resistance def: "Durlobactam is a broad-spectrum diazabicyclooctane beta-lactamase inhibitor capable to inhibiting class A, C, and D beta-lactamases." [PMID:34349751] is_a: ARO:3007008 ! diazabicyclooctane relationship: is_small_molecule_inhibitor ARO:3001419 ! OXA-24 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 synonym: "ETX-2514" EXACT [] xref: pubchem.compound:89851852 [Term] id: ARO:3007294 name: ANT-431 namespace: antibiotic_resistance def: "ANT-431 is an experimental beta-lactamase inhibitor shown to inhibit the action of NDM-1 and VIM-2." [PMID:29530861] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002272 ! VIM-2 xref: pubchem.compound:86566878 [Term] id: ARO:3007295 name: nacubactam namespace: antibiotic_resistance def: "Nacubactam is a diazabicyclooctane that inhibits a variety of class A and C beta-lactamases." [PMID:31182530] is_a: ARO:3007008 ! diazabicyclooctane relationship: is_small_molecule_inhibitor ARO:3000873 ! TEM-1 relationship: is_small_molecule_inhibitor ARO:3000882 ! TEM-10 relationship: is_small_molecule_inhibitor ARO:3001877 ! CTX-M-14 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3001906 ! CTX-M-44 relationship: is_small_molecule_inhibitor ARO:3002013 ! CMY-2 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 relationship: is_small_molecule_inhibitor ARO:3002497 ! PDC-1 xref: pubchem.compound:73386748 [Term] id: ARO:3007296 name: zidebactam namespace: antibiotic_resistance def: "Zidebactam is a diazabicyclooctane that inhibitors a variety of class A and C beta-lactamases." [PMID:30670419] is_a: ARO:3007008 ! diazabicyclooctane relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 relationship: is_small_molecule_inhibitor ARO:3002498 ! PDC-2 relationship: is_small_molecule_inhibitor ARO:3003853 ! ADC-7 xref: pubchem.compound:77846445 [Term] id: ARO:3007297 name: ARX1796 namespace: antibiotic_resistance def: "ARX1796 is an orally bioavailable prodrug of avibactam." [PMID:34357517] is_a: ARO:3007008 ! diazabicyclooctane relationship: is_small_molecule_inhibitor ARO:3000873 ! TEM-1 relationship: is_small_molecule_inhibitor ARO:3000875 ! TEM-3 relationship: is_small_molecule_inhibitor ARO:3000881 ! TEM-9 relationship: is_small_molecule_inhibitor ARO:3000882 ! TEM-10 relationship: is_small_molecule_inhibitor ARO:3000884 ! TEM-12 relationship: is_small_molecule_inhibitor ARO:3000896 ! TEM-26 relationship: is_small_molecule_inhibitor ARO:3000898 ! TEM-28 relationship: is_small_molecule_inhibitor ARO:3000937 ! TEM-71 relationship: is_small_molecule_inhibitor ARO:3001059 ! SHV-1 relationship: is_small_molecule_inhibitor ARO:3001060 ! SHV-2 relationship: is_small_molecule_inhibitor ARO:3001062 ! SHV-3 relationship: is_small_molecule_inhibitor ARO:3001063 ! SHV-4 relationship: is_small_molecule_inhibitor ARO:3001066 ! SHV-7 relationship: is_small_molecule_inhibitor ARO:3001076 ! SHV-18 relationship: is_small_molecule_inhibitor ARO:3001109 ! SHV-52 relationship: is_small_molecule_inhibitor ARO:3001396 ! OXA-1 relationship: is_small_molecule_inhibitor ARO:3001821 ! ACT-1 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3001886 ! CTX-M-24 relationship: is_small_molecule_inhibitor ARO:3001889 ! CTX-M-27 relationship: is_small_molecule_inhibitor ARO:3001917 ! CTX-M-55 relationship: is_small_molecule_inhibitor ARO:3001926 ! CTX-M-65 relationship: is_small_molecule_inhibitor ARO:3002019 ! CMY-8 relationship: is_small_molecule_inhibitor ARO:3002182 ! MOX-1 relationship: is_small_molecule_inhibitor ARO:3002195 ! IMP-4 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 relationship: is_small_molecule_inhibitor ARO:3002313 ! KPC-3 relationship: is_small_molecule_inhibitor ARO:3007180 ! MAB xref: pubchem.compound:135339165 [Term] id: ARO:3007298 name: ledaborbactam namespace: antibiotic_resistance def: "Ledaborbactam is an experimental boronic acid beta-lactamase inhibitor that has shown been show to inhibitor several serine beta-lactamases." [PMID:34001510] is_a: ARO:3007131 ! boronic acid beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3001064 ! SHV-5 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 synonym: "VNRX-5236" EXACT [] xref: pubchem.compound:138455079 [Term] id: ARO:3007299 name: ledaborbactam etzadroxil namespace: antibiotic_resistance def: "Ledaborbactam Etzadroxil is an orally bioavailable prodrug of ledaborbactam." [PMID:34191513] is_a: ARO:3007131 ! boronic acid beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3001064 ! SHV-5 relationship: is_small_molecule_inhibitor ARO:3001878 ! CTX-M-15 relationship: is_small_molecule_inhibitor ARO:3002312 ! KPC-2 synonym: "VNRX-7145" EXACT [] xref: pubchem.compound:138455030 [Term] id: ARO:3007300 name: L-captopril namespace: antibiotic_resistance def: "L-captopril is a drug used to treat hypertension that has been shown to chelate certain metallo-beta-lactamases." [PMID:26482303] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002198 ! IMP-7 relationship: is_small_molecule_inhibitor ARO:3002271 ! VIM-1 relationship: is_small_molecule_inhibitor ARO:3002878 ! BcII xref: pubchem.compound:44093 [Term] id: ARO:3007301 name: D-captopril namespace: antibiotic_resistance def: "D-captopril is an isomer of L-captopril and is able to chelate certain metallo-beta-lactamases." [PMID:26482303] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002198 ! IMP-7 relationship: is_small_molecule_inhibitor ARO:3002271 ! VIM-1 relationship: is_small_molecule_inhibitor ARO:3002878 ! BcII xref: pubchem.compound:447055 [Term] id: ARO:3007302 name: thiorphan namespace: antibiotic_resistance def: "Thiorphan is the active metabolite of the antidieuretic drug racecadotril. It has shown inhibitory activity against various metallo-beta-lactamases." [PMID:31663735] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002198 ! IMP-7 relationship: is_small_molecule_inhibitor ARO:3002271 ! VIM-1 xref: pubchem.compound:3132 [Term] id: ARO:3007303 name: tiopronin namespace: antibiotic_resistance def: "Tiopronin is a drug used to prevent and manage kidney stones in cystinuria patients. It has shown inhibitory activity against various metallo-beta-lactamases." [PMID:31663735] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002198 ! IMP-7 relationship: is_small_molecule_inhibitor ARO:3002271 ! VIM-1 xref: pubchem.compound:5483 [Term] id: ARO:3007304 name: dimercaprol namespace: antibiotic_resistance def: "Dimercaprol is a compound used to treat acute arsenic poisoning, as well as poisoning of other metals such as mercury, gold, and antimony. It has shown inhibitory activity against various metallo-beta-lactamases." [PMID:31663735] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002198 ! IMP-7 relationship: is_small_molecule_inhibitor ARO:3002271 ! VIM-1 xref: pubchem.compound:3080 [Term] id: ARO:3007305 name: ME1071 namespace: antibiotic_resistance def: "ME1071 is an experimental metallo-beta-lactamase inhibitor." [PMID:23891525] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 relationship: is_small_molecule_inhibitor ARO:3002192 ! IMP-1 relationship: is_small_molecule_inhibitor ARO:3002272 ! VIM-2 xref: pubchem.compound:16064853 [Term] id: ARO:3007306 name: phosphonoformate namespace: antibiotic_resistance def: "Phosphonoformate, also known as Forscarnet or Foscavir, is an antiviral drug used to treat Herpesviridae infections. It has also been shown to inhibit the fosfomycin thiol transferase fosA." [PMID:15504029, PMID:28993329] is_a: ARO:3007290 ! fosfomycin thiol transferase inhibitor relationship: is_small_molecule_inhibitor ARO:3000149 ! FosA synonym: "Foscarnet" EXACT [] synonym: "Foscavir" EXACT [] xref: pubchem.compound:3415 [Term] id: ARO:3007307 name: phosphonoacetate namespace: antibiotic_resistance def: "Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA." [PMID:15504029] is_a: ARO:3007290 ! fosfomycin thiol transferase inhibitor relationship: is_small_molecule_inhibitor ARO:3000149 ! FosA xref: pubchem.compound:546 [Term] id: ARO:3007308 name: acetylphosphonate namespace: antibiotic_resistance def: "Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA." [PMID:15504029] is_a: ARO:3007290 ! fosfomycin thiol transferase inhibitor relationship: is_small_molecule_inhibitor ARO:3000149 ! FosA xref: pubchem.compound:490 [Term] id: ARO:3007309 name: quercetin namespace: antibiotic_resistance def: "Quercetin is a common plant flavonoid that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. Quercetin is also able to inhibit antbiotic efflux pumps such as AcrAB-TolC." [PMID:23758273, PMID:31755586] is_a: ARO:3007291 ! inhibitor of aminoglycoside inactivation enzyme is_a: ARO:3007322 ! inhibitors of AcrAB-TolC efflux pump relationship: is_small_molecule_inhibitor ARO:3002647 ! APH(3')-IIIa relationship: is_small_molecule_inhibitor ARO:3002648 ! APH(3')-IVa xref: pubchem.compound:5280343 [Term] id: ARO:3007310 name: aranorosin namespace: antibiotic_resistance def: "Aranorosin is a plant derived compound that has shown inhibitory activity against certain aminoglycoside inactivation enzymes." [PMID:22760297] is_a: ARO:3007291 ! inhibitor of aminoglycoside inactivation enzyme relationship: is_small_molecule_inhibitor ARO:3002597 ! AAC(6')-Ie-APH(2'')-Ia bifunctional protein xref: pubchem.compound:6444217 [Term] id: ARO:3007311 name: pterostilbene namespace: antibiotic_resistance def: "Pterostilbene is a stilbenoid compound with antioxidant effects found in members of the genus Vaccinium (blueberries). It has also been shown to partially inhibit the mobile colistin resistance gene MCR-1." [PMID:29339386] is_a: ARO:3007292 ! MCR phosphoethanolamine transferase inhibitor relationship: is_small_molecule_inhibitor ARO:3003689 ! MCR-1.1 xref: pubchem.compound:5281727 [Term] id: ARO:3007312 name: SPR741 namespace: antibiotic_resistance def: "SPR741 is an experimental cationic peptide used to increase permeability of the outer membrane of Gram-negative bacteria. It is currently in clinical trials in combination with a variety of antibiotics." [PMID:28947471] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:53323381 [Term] id: ARO:3007313 name: KL-L9P namespace: antibiotic_resistance def: "KL-L9P is an experimental peptide used to increase the permeability of Gram-negative bacterial membranes to enhance the entry of antibiotics such as linezolid, rifampicin, and clarithromycin." [PMID:33205989] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:162646782 [Term] id: ARO:3007314 name: pentamidine namespace: antibiotic_resistance def: "Pentamidine is an antiparasitic compound used to treat a variety of infections such as African trypanosomiasis and leishamaniasis. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics. Pentamidine combined with linezolid had significant synergistic antibacterial effects against carbapenem-resistant Enterobacteriaceae pentamidine. The antimicrobial disrupts the outer membranes, dissipates the membrane potentials, and devitalizes the efflux pumps of CRE, thereby facilitating the intracellular accumulation of linezolid and reactive oxygen species (ROS), which ultimately kills the bacteria." [PMID:28263303] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry synonym: "Nebupent" EXACT [] synonym: "Pentam" EXACT [] xref: pubchem.compound:4735 [Term] id: ARO:3007315 name: MAC-0568743 namespace: antibiotic_resistance def: "MAC-0568743 is an experimental compound that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics." [PMID:33974796] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:2977394 [Term] id: ARO:3007316 name: liproxstatin-1 namespace: antibiotic_resistance def: "Liproxstatin-1 is a ferroptosis inhibitor that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics." [PMID:33974796] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:135735917 [Term] id: ARO:3007317 name: D-LANA14 namespace: antibiotic_resistance def: "D-LANA-14 is a d-lysine conjugated aliphatic norspermidine analogue that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of antibiotics. It is also able to inhibit the formation of bacterial biofilms." [PMID:31646866, PMID:28225264] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:140787320 [Term] id: ARO:3007318 name: metformin namespace: antibiotic_resistance def: "Metformin is a first-line medication for type 2 diabetes. It has been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics, such as tetracyclines, beta-lactams, and rifampicin. Metformin is also able to inhibit antibiotic efflux pumps such as AcrAB-TolC and MdtK." [PMID:32596101, PMID:34007223] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry is_a: ARO:3007322 ! inhibitors of AcrAB-TolC efflux pump is_a: ARO:3007328 ! inhibitors of MdtK efflux pump synonym: "Glucophage" EXACT [] xref: pubchem.compound:4091 [Term] id: ARO:3007319 name: bicarbonate namespace: antibiotic_resistance def: "Bicarbonate is an ion capable of increasing bacterial membrane permeability by altering the proton motive force. This enhances the entry of antibiotics." [PMID:29264917, PMID:32898415] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:769 [Term] id: ARO:3007320 name: phenylalanine-arginine beta-naphthylamide namespace: antibiotic_resistance def: "Phenylalanine-arginine beta-naphthylamide is a widely-used experimental efflux pump inhibitor. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of antibiotics, even in efflux pump deficient strains. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing." [PMID:33889361, PMID:23544160] is_a: ARO:3003932 ! antibiotic efflux inhibitor is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:443301 [Term] id: ARO:3007321 name: inhibitors of tetK efflux pump namespace: antibiotic_resistance def: "Compounds which inhibit the removal of antibiotics by the tetK efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007322 name: inhibitors of AcrAB-TolC efflux pump namespace: antibiotic_resistance def: "Compounds which inhibit the removal of antibiotics by the AcrAB-TolC efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007323 name: inhibitors of MdeA efflux pump namespace: antibiotic_resistance def: "Compounds which inhibit the removal of antibiotics by the MdeA efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007324 name: inhibitors of Rv1258c efflux pump namespace: antibiotic_resistance def: "Compounds which inhibit the removal of antibiotics by the Rv1258c (Tap) efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007325 name: inhibitors of NorA efflux pump namespace: antibiotic_resistance def: "Compounds which inhibit the removal of antibiotics by the NorA efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007326 name: inhibitors of CmeABC efflux pump namespace: antibiotic_resistance def: "Compounds which inhibit the removal of antibiotics by the CmeABC efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007327 name: inhibitors of MexAB-OprM efflux pump namespace: antibiotic_resistance def: "Compounds which inhibit the removal of antibiotics by the MexAB-OprM efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007328 name: inhibitors of MdtK efflux pump namespace: antibiotic_resistance def: "Compounds which inhibit the removal of antibiotics by the MdtK efflux pump." [] is_a: ARO:3003932 ! antibiotic efflux inhibitor [Term] id: ARO:3007329 name: baicalin namespace: antibiotic_resistance def: "Baicalin is a flavonoid compound that is able to inhibit the activity of tetK and MsrA antibiotic efflux pumps. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing." [PMID:28453568, PMID:31921008] is_a: ARO:3007077 ! inhibitors of MsrA efflux pump is_a: ARO:3007225 ! adjuvants which alter physiology is_a: ARO:3007321 ! inhibitors of tetK efflux pump synonym: "baicalein" EXACT [] xref: pubchem.compound:5281605 [Term] id: ARO:3007330 name: reserpine namespace: antibiotic_resistance def: "Reserpine is an alkaloid compound that is able to inhibit the activity of the AcrAB-TolC antibiotic efflux system." [PMID:31397441] is_a: ARO:3007322 ! inhibitors of AcrAB-TolC efflux pump xref: pubchem.compound:5770 [Term] id: ARO:3007331 name: piperine namespace: antibiotic_resistance def: "Piperine is an alkaloid compound that is able to inhibit the activity of NorA, MdeA, and Rv1258c (Tap) antibiotic efflux pumps." [PMID:21680766, PMID:18848780] is_a: ARO:3007323 ! inhibitors of MdeA efflux pump is_a: ARO:3007324 ! inhibitors of Rv1258c efflux pump is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:638024 [Term] id: ARO:3007332 name: piperidine namespace: antibiotic_resistance def: "Piperidine is an alkaloid compound that is able to inhibit the activity of the NorA antibiotic efflux pump." [PMID:18848780] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:8082 [Term] id: ARO:3007333 name: verapamil namespace: antibiotic_resistance def: "Verapamil is a blood-pressure medication that acts by blocking calcium channels. It is also able to inhibit the antibiotic efflux pump Rv1258c (Tap)." [PMID:24532601] is_a: ARO:3007324 ! inhibitors of Rv1258c efflux pump xref: pubchem.compound:2520 [Term] id: ARO:3007334 name: norverapamil namespace: antibiotic_resistance def: "Norverapamil is a metabolite of verapamil that is able to inhibit the antibiotic efflux pump Rv1258c (Tap)." [PMID:24532601] is_a: ARO:3007324 ! inhibitors of Rv1258c efflux pump xref: pubchem.compound:104972 [Term] id: ARO:3007335 name: chlorpromazine namespace: antibiotic_resistance def: "Chlorpromazine is a medication used to treat disorders such as schizophrenia. It is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC." [PMID:32487753] is_a: ARO:3007322 ! inhibitors of AcrAB-TolC efflux pump synonym: "Largactil" EXACT [] synonym: "Thorazine" EXACT [] xref: pubchem.compound:2726 [Term] id: ARO:3007336 name: amitriptyline namespace: antibiotic_resistance def: "Amitriptyline is an antidepressant used to treat a variety of conditions such as cyclic vomiting syndrome, major depressive disorder, fibromyalgia. Is is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC." [PMID:32487753] is_a: ARO:3007322 ! inhibitors of AcrAB-TolC efflux pump synonym: "Elavil" EXACT [] xref: pubchem.compound:2160 [Term] id: ARO:3007337 name: thioridazine namespace: antibiotic_resistance def: "Thioridazine is a phenothiazine drug used in the treatment of schizophrenia and psychosis. It is also able to inhibit mycobacterial antibiotic efflux pumps and the formation of bacterial biofilms." [PMID:32312774, PMID:18836028] is_a: ARO:3003932 ! antibiotic efflux inhibitor is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:5452 [Term] id: ARO:3007338 name: biochanin A namespace: antibiotic_resistance def: "Biochanin A is a flavonoid compound that is able to inhibit mycobacterial antibiotic efflux pumps." [PMID:28964936] is_a: ARO:3003932 ! antibiotic efflux inhibitor xref: pubchem.compound:5280373 [Term] id: ARO:3007339 name: phloretin namespace: antibiotic_resistance def: "Phloretin is a plant-derived phenol that is able to inhibit the antibiotic efflux pump NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:4788 [Term] id: ARO:3007340 name: epigallocatechin gallate namespace: antibiotic_resistance def: "Epigallocatechin gallate is a flavonol that is able to inhibit antibiotic efflux pumps such as CmeABC, NorA, and tetK." [PMID:15155186, PMID:15643566] is_a: ARO:3007321 ! inhibitors of tetK efflux pump is_a: ARO:3007325 ! inhibitors of NorA efflux pump is_a: ARO:3007326 ! inhibitors of CmeABC efflux pump xref: pubchem.compound:65064 [Term] id: ARO:3007341 name: hesperetin namespace: antibiotic_resistance def: "Hesperetin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:72281 [Term] id: ARO:3007342 name: naringenin namespace: antibiotic_resistance def: "Naringenin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:932 [Term] id: ARO:3007343 name: sophoraflavanone G namespace: antibiotic_resistance def: "Sophoraflavanone G is a phytoncide derived from members of the Sophora genus. It is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:72936 [Term] id: ARO:3007344 name: chrysoeriol namespace: antibiotic_resistance def: "Chrysoeriol is a derivative of the flavone luteolin. It has been shown to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5280666 [Term] id: ARO:3007345 name: sideroxylin namespace: antibiotic_resistance def: "Sideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:22814821] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:3083788 [Term] id: ARO:3007346 name: 6-desmethylsideroxylin namespace: antibiotic_resistance def: "6-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:22814821] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:56665369 [Term] id: ARO:3007347 name: 8-desmethylsideroxylin namespace: antibiotic_resistance def: "8-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:22814821] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:44258359 [Term] id: ARO:3007348 name: diosmetin namespace: antibiotic_resistance def: "Diosmetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5281612 [Term] id: ARO:3007349 name: chrysosplenetin namespace: antibiotic_resistance def: "Chrysoplenetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5281608 [Term] id: ARO:3007350 name: galangin namespace: antibiotic_resistance def: "Galangin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5281616 [Term] id: ARO:3007351 name: kaempferol namespace: antibiotic_resistance def: "Kaempferol is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5280863 [Term] id: ARO:3007352 name: kaempferol rhamnoside namespace: antibiotic_resistance def: "Kaempferol rhamnoside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:44259088 [Term] id: ARO:3007353 name: myricitrin namespace: antibiotic_resistance def: "Myricitrin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5281673 [Term] id: ARO:3007354 name: penduletin namespace: antibiotic_resistance def: "Pendeuletin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5320462 [Term] id: ARO:3007355 name: tiliroside namespace: antibiotic_resistance def: "Tiliroside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:34833994] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5320686 [Term] id: ARO:3007356 name: daidzein namespace: antibiotic_resistance def: "Daidzein is a flavonolignan compound found in soybeans and other legumes. It has been shown to inhibit antibiotic efflux pumps such as AcrAB-TolC and MexAB-OprM." [PMID:34833994] is_a: ARO:3007322 ! inhibitors of AcrAB-TolC efflux pump is_a: ARO:3007327 ! inhibitors of MexAB-OprM efflux pump xref: pubchem.compound:5281708 [Term] id: ARO:3007357 name: genistein namespace: antibiotic_resistance def: "Genistein is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:32923005] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5280961 [Term] id: ARO:3007358 name: orobol namespace: antibiotic_resistance def: "Orobol is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA." [PMID:32923005] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:5281801 [Term] id: ARO:3007359 name: MBX-2319 namespace: antibiotic_resistance def: "MBX-2319 is an experimental compound used to inhibit the AcrAB-TolC antibiotic efflux system." [PMID:25114133] is_a: ARO:3007322 ! inhibitors of AcrAB-TolC efflux pump xref: pubchem.compound:1289417 [Term] id: ARO:3007360 name: capsaicin namespace: antibiotic_resistance def: "Capsaicin is a compound found in chili peppers and is used to treat nerve pain. It is also able to inhibit antibiotic efflux pumps such as NorA." [PMID:22807321] is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:1548943 [Term] id: ARO:3007361 name: rutin namespace: antibiotic_resistance def: "Rutin is a plant pigment that is able to inhibit bacterial biofilm formation." [PMID:34456739] is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:5280805 [Term] id: ARO:3007362 name: citral namespace: antibiotic_resistance def: "Citral is a monoterpene aldehyde derived from a variety of plant oils that is able to inhibit bacterial biofilm formation and quorum sensing." [PMID:33392626] is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:638011 [Term] id: ARO:3007363 name: furanone namespace: antibiotic_resistance def: "Furanone is a heterocyclic organic compound that disrupts bacterial quorum sensing." [PMID:31971503] is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:140765 [Term] id: ARO:3007364 name: cefepime-tazobactam namespace: antibiotic_resistance def: "A mixture of the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor tazobactam." [PMID:33716176] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000059 ! cefepime relationship: has_part ARO:0000077 ! tazobactam xref: pubchem.compound:9567558 [Term] id: ARO:3007365 name: cefepime-enmetazobactam namespace: antibiotic_resistance def: "A mixture of the beta-lactam antibiotic cepefime and the beta-lactamase inhibitor enmetazobactam." [PMID:35471043] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:0000059 ! cefepime relationship: has_part ARO:3007171 ! enmetazobactam [Term] id: ARO:3007366 name: aztreonam-avibactam namespace: antibiotic_resistance def: "A mixture of the beta-lactam antibiotic aztreonam and the beta-lactamase inhibitor avibactam." [PMID:35760303] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000550 ! aztreonam relationship: has_part ARO:3000588 ! avibactam [Term] id: ARO:3007367 name: L-CS319 namespace: antibiotic_resistance def: "L-CS319 is an experimental bisthiazolidine metallo-beta-lactamase inhibitor capable of inhibiting the action of NDM-1." [PMID:27623409] is_a: ARO:3007135 ! bisthiazolidine metallo-beta-lactamase inhibitor relationship: is_small_molecule_inhibitor ARO:3000589 ! NDM-1 xref: pubchem.compound:76936796 [Term] id: ARO:3007368 name: FosG namespace: antibiotic_resistance def: "FosG is a glutathione transferase that confers resistance to fosfomycin." [PMID:33199384] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosG" EXACT CARD_Short_Name [] [Term] id: ARO:3007369 name: FosH namespace: antibiotic_resistance def: "FosH is a hydrolase that confers resistance to fosfomycin." [PMID:33199384] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosH" EXACT CARD_Short_Name [] [Term] id: ARO:3007370 name: FosI namespace: antibiotic_resistance def: "FosI is a fosfomycin resistance gene." [PMID:26552984] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosI" EXACT CARD_Short_Name [] [Term] id: ARO:3007371 name: FosA8 namespace: antibiotic_resistance def: "FosA8 is a plasmid-located fosfomycin resistance gene." [PMID:31481445] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosA8" EXACT CARD_Short_Name [] [Term] id: ARO:3007372 name: FosBx1 namespace: antibiotic_resistance def: "FosBx1 is a fosfomycin resistance gene." [PMID:33199384] is_a: ARO:3000133 ! fosfomycin thiol transferase relationship: confers_resistance_to_antibiotic ARO:0000025 ! fosfomycin synonym: "FosBx1" EXACT CARD_Short_Name [] [Term] id: ARO:3007373 name: PJM beta-lactamase namespace: antibiotic_resistance def: "A family of subclass B3 metallo-beta-lactamases with activity against a range of beta-lactam antibiotics." [PMID:35943258] is_a: ARO:3000571 ! subclass B3 (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007374 name: PJM-1 namespace: antibiotic_resistance def: "PJM-1 is a chromosomally-encoded subclass B3 metallo-beta-lactamase found in P. japonensis confering resistance to a range of antibiotics including ampicillin, cefalotin, and cefoxitin." [PMID:35943258] is_a: ARO:3007373 ! PJM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "PJM-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007375 name: KPC-87 namespace: antibiotic_resistance def: "KPC-87 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia." [PMID:36003991] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem synonym: "KPC-87" EXACT CARD_Short_Name [] [Term] id: ARO:3007376 name: gentamicin X namespace: antibiotic_resistance def: "Gentamicin X is an aminoglycoside antibiotic. It is a precursor of gentamicin C and a minor component of the gentamicin antibiotic mixture." [PMID:25641167] is_a: ARO:3007382 ! gentamicin synonym: "gentamicin X2" EXACT [] xref: pubchem.compound:15574862 [Term] id: ARO:3007377 name: 6'-N-ethylnetilmicin namespace: antibiotic_resistance def: "6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin." [PMID:8385262] is_a: ARO:0000016 ! aminoglycoside antibiotic xref: pubchem.compound:15344654 [Term] id: ARO:3007378 name: 2'-N-ethylnetilmicin namespace: antibiotic_resistance def: "2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin." [PMID:8385262] is_a: ARO:0000016 ! aminoglycoside antibiotic xref: pubchem.compound:101649392 [Term] id: ARO:3007379 name: 5-episisomicin namespace: antibiotic_resistance def: "5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin." [PMID:697347] is_a: ARO:0000016 ! aminoglycoside antibiotic synonym: "pentisomicin" EXACT [] xref: pubchem.compound:65453 [Term] id: ARO:3007380 name: aminoglycoside modifying enzyme namespace: antibiotic_resistance def: "Resistance-conferring genetic elements encoding proteins involved in the enzymatic inactivation of aminoglycoside antibiotics through chemical modification." [] is_a: ARO:3000557 ! antibiotic inactivation enzyme [Term] id: ARO:3007381 name: KPC-86 namespace: antibiotic_resistance def: "KPC-86 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia." [PMID:36003991] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "KPC-86" EXACT CARD_Short_Name [] [Term] id: ARO:3007382 name: gentamicin namespace: antibiotic_resistance def: "Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex)." [PMID:28507482] is_a: ARO:0000016 ! aminoglycoside antibiotic is_a: ARO:3000707 ! antibiotic mixture synonym: "Cidomycin" EXACT [] synonym: "Garamycin" EXACT [] synonym: "Gentacycol" EXACT [] synonym: "Gentamicins" EXACT [] synonym: "Gentamicinum" EXACT [] synonym: "Gentavet" EXACT [] xref: pubchem.compound:3467 [Term] id: ARO:3007383 name: KPC-95 namespace: antibiotic_resistance def: "KPC-95 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia." [PMID:35038557] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "KPC-95" EXACT CARD_Short_Name [] [Term] id: ARO:3007384 name: AAC(3)-I namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin through enzymatic acetylation, thereby conferring resistance to these compounds." [PMID:8385262] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007385 name: AAC(3)-II namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds." [PMID:8385262] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007386 name: AAC(3)-III namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and kanamycin through enzymatic acetylation, thereby conferring resistance to these compounds." [PMID:8385262] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007387 name: AAC(3)-IV namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and apramycin through enzymatic acetylation, thereby conferring resistance to these compounds." [PMID:8385262] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007388 name: AAC(3)-VI namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and ethylnetilmicin through enzymatic acetylation, thereby conferring resistance to these compounds." [PMID:8385262] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007389 name: AAC(3)-VII namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate paronomycin through enzymatic acetylation, thereby conferring resistance to these compounds." [] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007390 name: AAC(3)-VIII namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate neomycin through enzymatic acetylation, thereby conferring resistance to these compounds." [] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007391 name: AAC(3)-IX namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate neomycin through enzymatic acetylation, thereby conferring resistance to these compounds." [] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007392 name: AAC(3)-X namespace: antibiotic_resistance def: "A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate kanamycin through enzymatic acetylation, thereby conferring resistance to these compounds." [] is_a: ARO:3000322 ! AAC(3) [Term] id: ARO:3007393 name: AAC(2')-I namespace: antibiotic_resistance def: "A family of aminoglycoside 2'-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds." [] is_a: ARO:3000341 ! AAC(2') [Term] id: ARO:3007394 name: AAC(2')-II namespace: antibiotic_resistance def: "A family of aminoglycoside 2'-N-acetyltransferase enzymes which inactivate kasugamycin through enzymatic acetylation, thereby conferring resistance to these compounds." [] is_a: ARO:3000341 ! AAC(2') [Term] id: ARO:3007395 name: AAC(6')-I namespace: antibiotic_resistance def: "A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate amikacin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds." [PMID:8385262] is_a: ARO:3000345 ! AAC(6') [Term] id: ARO:3007396 name: AAC(6')-II namespace: antibiotic_resistance def: "A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds." [PMID:8385262] is_a: ARO:3000345 ! AAC(6') [Term] id: ARO:3007397 name: Swedish Reference Group for Antibiotics (SIR) namespace: antibiotic_resistance def: "SIR is a revised system for antibiotic sensitivity testing in Sweden that was proposed in 1977. The SIR system included two main changes: three sensitivity groups instead of the previous four and new breakpoints for the sensitivity groups." [DOI:10.3109/inf.1981.13.issue-2.13] is_a: ARO:3004360 ! antimicrobial resistance testing reference standard [Term] id: ARO:3007398 name: Werkgroep Richtlijnen Gevoeligheidsbepalingen (WRG) namespace: antibiotic_resistance def: "The WRG is a standardized antimicrobial susceptibility testing methodology created by the Dutch Commissie Richtlijnen Gevoeligheidsbepalingen in 1981." [DOI:10.1007/bf01964289] is_a: ARO:3004360 ! antimicrobial resistance testing reference standard synonym: "Commissie Richtlijnen Gevoeligheidsbepalingen (CRG)" EXACT [] synonym: "Committee Guidelines Susceptibility Testing" EXACT [] synonym: "Working Group Guidelines Susceptibility Testing" EXACT [] [Term] id: ARO:3007399 name: ANT(6)-I namespace: antibiotic_resistance def: "A family of aminoglycoside 6-O-nucleotidyltransferase enzymes which inactivate streptomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds." [PMID:8385262, PMID:20833577] is_a: ARO:3000225 ! ANT(6) [Term] id: ARO:3007400 name: ANT(9)-I namespace: antibiotic_resistance def: "A family of aminoglycoside 9-O-nucleotidyltransferase enzymes which inactivate spectinomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds." [PMID:8385262, PMID:20833577] is_a: ARO:3000228 ! ANT(9) [Term] id: ARO:3007401 name: ANT(9)-Ib namespace: antibiotic_resistance def: "A plasmid-borne ANT(9)-I variant identified from Enterococcus faecalis. ANT(9)-Ib confers resistance to spectinomycin through enzymatic inactivation." [PMID:1659306] is_a: ARO:3007400 ! ANT(9)-I relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "ANT(9)-Ib" EXACT CARD_Short_Name [] [Term] id: ARO:3007402 name: KPC-94 namespace: antibiotic_resistance def: "KPC-94 is a mutated carbapenemase allele found in Klebsiella pneumoniae." [PMID:35038557] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem synonym: "KPC-94" EXACT CARD_Short_Name [] [Term] id: ARO:3007403 name: ANT(4')-I namespace: antibiotic_resistance def: "A family of aminoglycoside 4'-O-nucleotidyltransferase enzymes which inactivate amikacin, tobramycin & dibekacin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds." [] is_a: ARO:3000229 ! ANT(4') [Term] id: ARO:3007404 name: ANT(4')-II namespace: antibiotic_resistance def: "A family of aminoglycoside 4'-O-nucleotidyltransferase enzymes which inactivate amikacin & tobramycin, but not dibekacin, by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds." [] is_a: ARO:3000229 ! ANT(4') [Term] id: ARO:3007405 name: ANT(2'')-I namespace: antibiotic_resistance def: "A family of aminoglycoside 2''-O-nucleotidyltransferase enzymes which inactivate gentamicin, tobramycin & dibekacin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds." [] is_a: ARO:3004276 ! ANT(2'') [Term] id: ARO:3007406 name: APH(3')-I namespace: antibiotic_resistance def: "A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kamamycin, neomycin & lividomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds." [] is_a: ARO:3000126 ! APH(3') [Term] id: ARO:3007407 name: ANT(3'')-I namespace: antibiotic_resistance def: "A family of aminoglycoside O-nucleotidyltransferase enzymes which inactivate streptomycin and spectinomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. These enzymes modify the 3''-hydroxyl position of streptomycin and the 9-hydroxyl position of spectinomycin." [] is_a: ARO:3004275 ! ANT(3'') [Term] id: ARO:3007408 name: APH(3')-II namespace: antibiotic_resistance def: "A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin and butirosin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds." [] is_a: ARO:3000126 ! APH(3') [Term] id: ARO:3007409 name: APH(3')-III namespace: antibiotic_resistance def: "A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, butirosin and lividomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds." [] is_a: ARO:3000126 ! APH(3') [Term] id: ARO:3007410 name: APH(3')-IV namespace: antibiotic_resistance def: "A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, ribostamycin and butirosin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds." [] is_a: ARO:3000126 ! APH(3') [Term] id: ARO:3007411 name: APH(3')-V namespace: antibiotic_resistance def: "A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate neomycin, paromomycin and ribostamycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds." [] is_a: ARO:3000126 ! APH(3') [Term] id: ARO:3007412 name: APH(3')-VI namespace: antibiotic_resistance def: "A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, ribostamycin and butirosin, as well as amikacin and isepomicin, by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds." [] is_a: ARO:3000126 ! APH(3') [Term] id: ARO:3007413 name: APH(3')-VII namespace: antibiotic_resistance def: "A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin and neomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. It is also possible to observe low-level sub-breakpoint amikacin resistance dependent on testing standards and breakpoint criteria." [] is_a: ARO:3000126 ! APH(3') [Term] id: ARO:3007414 name: APH(3'')-I namespace: antibiotic_resistance def: "A family of aminoglycoside 3''-O-phosphotransferase enzymes which inactivate streptomycin by catalyzing the ATP-dependent phosphorylation of the 3''-hydroxyl group, thereby conferring resistance." [] is_a: ARO:3000127 ! APH(3'') [Term] id: ARO:3007415 name: APH(6)-I namespace: antibiotic_resistance def: "A family of aminoglycoside 6-O-phosphotransferase enzymes which inactivate streptomycin by catalyzing the ATP-dependent phosphorylation of the 6-hydroxyl group, thereby conferring resistance." [] is_a: ARO:3000151 ! APH(6) [Term] id: ARO:3007416 name: APH(9)-I namespace: antibiotic_resistance def: "A family of aminoglycoside 9-O-phosphotransferase enzymes which inactivate spectinomycin by catalyzing the ATP-dependent phosphorylation of the 9-hydroxyl group, thereby conferring resistance." [] is_a: ARO:3000153 ! APH(9) [Term] id: ARO:3007417 name: APH(7'')-I namespace: antibiotic_resistance def: "A family of aminoglycoside 7''-O-phosphotransferase enzymes which inactivate hygromycin by catalyzing the ATP-dependent phosphorylation of the 7''-hydroxyl group, thereby conferring resistance." [] is_a: ARO:3000154 ! APH(7'') [Term] id: ARO:3007418 name: APH(4)-I namespace: antibiotic_resistance def: "A family of aminoglycoside 4-O-phosphotransferase enzymes which inactivate hygromycin by catalyzing the ATP-dependent phosphorylation of the 4-hydroxyl group, thereby conferring resistance." [] is_a: ARO:3000155 ! APH(4) [Term] id: ARO:3007419 name: aminoglycoside bifunctional resistance protein namespace: antibiotic_resistance def: "Bifunctional aminoglycoside-inactivating enzymes composed of two separate functional domains. These proteins possess activity from both enzyme components, thereby conferring resistance to the combination of antibiotics from both domains, and may include acetylation, phosphorylation or nucleotidylation activity." [] is_a: ARO:3007380 ! aminoglycoside modifying enzyme relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic [Term] id: ARO:3007420 name: Klebsiella pneumoniae lamB with mutations conferring resistance to ceftazidime-avibactam namespace: antibiotic_resistance def: "LamB is a maltoporin that negatively regulates antibiotic resistance. Knockout strains of lamB are shown to exhibit higher levels of resistance than wild-type strains. Mutations in the lamB gene of Klebsiella are associated with resistance to ceftazidime-avibactam." [PMID:34551677] is_a: ARO:3004279 ! Sugar Porin (SP) relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "Kpne_lamB_CZA" EXACT CARD_Short_Name [] [Term] id: ARO:3007421 name: Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam namespace: antibiotic_resistance def: "Mutant PBP3 in Klebsiella pneumoniae conferring resistance to ceftazidime-avibactam." [PMID:34551677] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "Kpne_PBP3_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3007422 name: ceftaroline-avibactam namespace: antibiotic_resistance def: "A combiation of the beta-lactam antibiotic ceftaroline and the beta-lactamase inhibitor avibactam." [PMID:22441578] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000588 ! avibactam relationship: has_part ARO:3000651 ! ceftaroline [Term] id: ARO:3007423 name: Escherichia coli PBP3 mutants conferring resistance to beta-lactam antibiotics namespace: antibiotic_resistance def: "Mutant PBP3 in E. coli conferring resistance to beta-lactams, including beta-lactam/beta-lactamase inhibitor combinations." [PMID:28559260, PMID:25634992] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: confers_resistance_to_antibiotic ARO:3000651 ! ceftaroline synonym: "Ecol_PBP3_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3007424 name: resistance by host-dependent nutrient acquisition namespace: antibiotic_resistance def: "Resistance via uptake of host nutrients to bypass antibiotic mechanism." [PMID:36450721] is_a: ARO:1000002 ! mechanism of antibiotic resistance [Term] id: ARO:3007425 name: protein(s) conferring resistance via host-dependent nutrient acquisition namespace: antibiotic_resistance def: "Proteins involved in the uptake of host-nutrients to bypass antibiotic resistance mechanisms." [] is_a: ARO:3000000 ! determinant of antibiotic resistance relationship: participates_in ARO:3007424 ! resistance by host-dependent nutrient acquisition [Term] id: ARO:3007426 name: ECF transporter S component namespace: antibiotic_resistance def: "ECF transporter S component genes involved in host nutrient uptake." [PMID:36450721] is_a: ARO:3007425 ! protein(s) conferring resistance via host-dependent nutrient acquisition relationship: confers_resistance_to_drug_class ARO:3000282 ! sulfonamide antibiotic [Term] id: ARO:3007427 name: ThfT namespace: antibiotic_resistance def: "ThfT is an ECF transporter S component that expands the substrate profile of endogenous ECF transporters to include folate biosynthesis end products. It confers resistance to the folate synthesis inhibitor sulfamethoxazole by allowing uptake of host folate." [PMID:36450721] is_a: ARO:3007426 ! ECF transporter S component relationship: confers_resistance_to_antibiotic ARO:3000329 ! sulfamethoxazole synonym: "ThfT" EXACT CARD_Short_Name [] [Term] id: ARO:3007428 name: polymyxin resistance operon namespace: antibiotic_resistance def: "Operon or gene clusters confering resistance to polymyxin antibiotics." [PMID:25068415] is_a: ARO:0000010 ! antibiotic resistance gene cluster, cassette, or operon relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3007429 name: gene(s) or protein(s) associated with polymyxin resistance operon namespace: antibiotic_resistance def: "Various genes and proteins involved in intrinsic polymyxin resistance operons." [] is_a: ARO:3000000 ! determinant of antibiotic resistance [Term] id: ARO:3007430 name: alm glycyl carrier protein namespace: antibiotic_resistance def: "Glycyl carrier proteins associated with polymixin resistance operons." [PMID:25068415] is_a: ARO:3003580 ! gene altering cell wall charge is_a: ARO:3007429 ! gene(s) or protein(s) associated with polymyxin resistance operon relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3007431 name: almF namespace: antibiotic_resistance def: "almF is a glycine carrier protein associated with the almEFG operon in Vibrio cholerae. It is activated by almE and carries the glycyl molecule later added to lipid A by almG." [PMID:25068415] is_a: ARO:3007430 ! alm glycyl carrier protein relationship: part_of ARO:3007434 ! almEFG synonym: "almF" EXACT CARD_Short_Name [] [Term] id: ARO:3007432 name: alm glycyltransferase namespace: antibiotic_resistance def: "Glycyl transferase associated with polymyxin resistance operons not interacting with lipid A." [PMID:25068415] is_a: ARO:3003580 ! gene altering cell wall charge is_a: ARO:3007429 ! gene(s) or protein(s) associated with polymyxin resistance operon relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3007433 name: almE namespace: antibiotic_resistance def: "almE is a glycyltransferase found in Vibrio cholerae that transfers glycine to the carrier protein almF. almE is part of the almEFG polymyxin resistance operon." [PMID:25068415] is_a: ARO:3007432 ! alm glycyltransferase relationship: part_of ARO:3007434 ! almEFG synonym: "almE" EXACT CARD_Short_Name [] [Term] id: ARO:3007434 name: almEFG namespace: antibiotic_resistance def: "The almEFG operon is responsible for glycylation of lipid A as a mechanism of colistin resistance in Vibrio cholerae. Its mechanism involves transfer of a glycyl molecule to the carrier protein almF by almE followed by glycylation of lipid A by almG." [PMID:25068415] is_a: ARO:3003580 ! gene altering cell wall charge is_a: ARO:3007428 ! polymyxin resistance operon relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "almEFG" EXACT CARD_Short_Name [] [Term] id: ARO:3007435 name: WUS-1 namespace: antibiotic_resistance def: "WUS-1 is a WUS beta-lactamase." [PMID:36532482] is_a: ARO:3007440 ! WUS beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000043 ! carbenicillin relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "WUS-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007436 name: KPC-96 namespace: antibiotic_resistance def: "KPC-96 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "KPC-96" EXACT CARD_Short_Name [] [Term] id: ARO:3007437 name: EBR-5 namespace: antibiotic_resistance def: "EBR-5 is an EBR beta-lactamase." [PMID:36719228] is_a: ARO:3004204 ! EBR beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3004006 ! ceftiofur synonym: "EBR-5" EXACT CARD_Short_Name [] [Term] id: ARO:3007438 name: LAQ-1 namespace: antibiotic_resistance def: "LAQ-1 beta lactamase is a class C beta lactamase." [PMID:36504772] is_a: ARO:3007441 ! LAQ beta lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000059 ! cefepime relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "LAQ-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007439 name: SSA beta-lactamase namespace: antibiotic_resistance def: "SSA beta-lactamases are a family of Class A beta-lactamases." [PMID:36626997] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007440 name: WUS beta-lactamase namespace: antibiotic_resistance def: "WUS is a family of the metallo-beta-lactamases." [PMID:36532482] is_a: ARO:3000004 ! class B (metallo-) beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007441 name: LAQ beta lactamase namespace: antibiotic_resistance def: "LAQ is a class C beta lactamase." [PMID:36504772] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000044 ! cephamycin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007442 name: SSA namespace: antibiotic_resistance def: "SSA is an SSA beta lactamase." [PMID:36626997] is_a: ARO:3007439 ! SSA beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "SSA" EXACT CARD_Short_Name [] [Term] id: ARO:3007443 name: NDM-44 namespace: antibiotic_resistance def: "NDM-44 is a subclass B1 NDM metallo-beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-44" EXACT CARD_Short_Name [] [Term] id: ARO:3007444 name: NDM-45 namespace: antibiotic_resistance def: "NDM-45 is a NDM class B metallo beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-45" EXACT CARD_Short_Name [] [Term] id: ARO:3007445 name: NDM-46 namespace: antibiotic_resistance def: "NDM-46 is an NDM metallo-beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-46" EXACT CARD_Short_Name [] [Term] id: ARO:3007446 name: KPC-100 namespace: antibiotic_resistance def: "KPC-100 is an inhibitor-resistant carbapenem-hydrolyzing KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "KPC-100" EXACT CARD_Short_Name [] [Term] id: ARO:3007447 name: NDM-47 namespace: antibiotic_resistance def: "NDM-47 is a NDM metallo-beta-lactamase." [] is_a: ARO:3000057 ! NDM beta-lactamase synonym: "NDM-47" EXACT CARD_Short_Name [] [Term] id: ARO:3007448 name: TEM-246 namespace: antibiotic_resistance def: "TEM-246 is a class A TEM beta-lactamase found in Neisseria gonorrhoeae." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-246" EXACT CARD_Short_Name [] [Term] id: ARO:3007449 name: KPC-97 namespace: antibiotic_resistance def: "KPC-97 is a KPC class A beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "KPC-97" EXACT CARD_Short_Name [] [Term] id: ARO:3007450 name: KPC-98 namespace: antibiotic_resistance def: "KPC-98 is a KPC beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "KPC-98" EXACT CARD_Short_Name [] [Term] id: ARO:3007451 name: TEM-247 namespace: antibiotic_resistance def: "TEM-247 is a TEM class A beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-247" EXACT CARD_Short_Name [] [Term] id: ARO:3007452 name: KPC-99 namespace: antibiotic_resistance def: "KPC-99 is a KPC class A beta-lactamase." [] is_a: ARO:3000059 ! KPC beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "KPC-99" EXACT CARD_Short_Name [] [Term] id: ARO:3007453 name: TEM-244 namespace: antibiotic_resistance def: "TEM-244 is a TEM beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-244" EXACT CARD_Short_Name [] [Term] id: ARO:3007454 name: TEM-245 namespace: antibiotic_resistance def: "TEM-245 is a TEM class A beta-lactamase." [] is_a: ARO:3000014 ! TEM beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000060 ! ceftazidime synonym: "TEM-245" EXACT CARD_Short_Name [] [Term] id: ARO:3007455 name: cethromycin namespace: antibiotic_resistance def: "Cethromycin is a ketolide (macrolide) antibiotic, with a similar mechanism to telithromycin, with activity against selected gram-positive, gram-negative, atypical bacteria, and even designed for tularemia, plague, and anthrax prophylaxis." [PMID:37081393] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:447451 [Term] id: ARO:3007456 name: dfrL namespace: antibiotic_resistance def: "dfrL is a gene encoding a trimethoprim-resistant dihydrofolate reductase (DHFR) identified in Staphylococcus aureus." [PMID:36935372] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:0000040 ! streptomycin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000052 ! tobramycin relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim relationship: confers_resistance_to_antibiotic ARO:3000337 ! iclaprim synonym: "dfrL" EXACT CARD_Short_Name [] [Term] id: ARO:3007457 name: carrimycin namespace: antibiotic_resistance def: "Carrimycin is a macrolide antibiotic produced by genetically engineered Streptomyces spiramyceticus and may be active against some Gram-positive bacteria and Mycobacterium tuberculosis." [PMID:37113529] is_a: ARO:0000000 ! macrolide antibiotic synonym: "bitespiramycin" EXACT [] [Term] id: ARO:3007458 name: cefovecin namespace: antibiotic_resistance def: "Cefovecin is a new extended-spectrum semisynthetic cephalosporin indicated for the treatment of a broad-spectrum of Gram-positive and Gram-negative bacterial infections in dogs and cats." [PMID:37107106] is_a: ARO:0000032 ! cephalosporin xref: pubchem.compound:6336480 [Term] id: ARO:3007459 name: EstT namespace: antibiotic_resistance def: "EstT is a gene encoding for a serine-dependent macrolide alpha/beta-hydrolase." [PMID:36791107] is_a: ARO:3000320 ! macrolide esterase relationship: confers_resistance_to_antibiotic ARO:0000030 ! tigecycline synonym: "EstT" EXACT CARD_Short_Name [] [Term] id: ARO:3007460 name: IMP-91 namespace: antibiotic_resistance def: "IMP-91 is an IMP beta-lactamase." [PMID:37092959] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-91" EXACT CARD_Short_Name [] [Term] id: ARO:3007461 name: IMP-96 namespace: antibiotic_resistance def: "IMP-96 is an IMP beta-lactamase." [PMID:37092959] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-96" EXACT CARD_Short_Name [] [Term] id: ARO:3007462 name: IMP-92 namespace: antibiotic_resistance def: "IMP-92 is an IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-92" EXACT CARD_Short_Name [] [Term] id: ARO:3007463 name: IMP-93 namespace: antibiotic_resistance def: "IMP-93 is an IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-93" EXACT CARD_Short_Name [] [Term] id: ARO:3007464 name: IMP-94 namespace: antibiotic_resistance def: "IMP-94 is an IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-94" EXACT CARD_Short_Name [] [Term] id: ARO:3007465 name: IMP-95 namespace: antibiotic_resistance def: "IMP-95 is an IMP beta-lactamase." [] is_a: ARO:3000020 ! IMP beta-lactamase synonym: "IMP-95" EXACT CARD_Short_Name [] [Term] id: ARO:3007466 name: BP2 namespace: antibiotic_resistance def: "BP2 is a novel beta-lactam-derived beta-lactamase inhibitor, efficacious when co-administered with meropenem in K. pneumoniae." [PMID:37106995] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor [Term] id: ARO:3007467 name: sulbactam-durlobactam namespace: antibiotic_resistance def: "SUL-DUR or sulbactam-durlobactam (formerly ETX2514SUL) is a novel beta-lactam-beta-lactamase inhibitor designed specifically for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB)." [PMID:37052117] is_a: ARO:3000707 ! antibiotic mixture relationship: has_part ARO:3000587 ! sulbactam relationship: has_part ARO:3007293 ! durlobactam synonym: "ETX2514SUL" EXACT [] [Term] id: ARO:3007468 name: sulfanilamide namespace: antibiotic_resistance def: "Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans." [PMID:37081146] is_a: ARO:3000282 ! sulfonamide antibiotic xref: pubchem.compound:5333 [Term] id: ARO:3007469 name: sulfamerazine namespace: antibiotic_resistance def: "Sulfamerazine is a sulfonamide anti-infective used to treat bacterial infections, such as bronchitis, prostatitis, and urinary tract infections." [PMID:37081146] is_a: ARO:3000282 ! sulfonamide antibiotic xref: pubchem.compound:5325 [Term] id: ARO:3007470 name: IND-17 namespace: antibiotic_resistance def: "IND-17 is an IND beta-lactamase and confers resistance to ampicillin, nitrocefin, cefazolin, cefuroxime, ceftazidime, imipenem, meropenem in Chryseobacterium spp." [PMID:37047008] is_a: ARO:3000060 ! IND beta-lactamase synonym: "IND-17" EXACT CARD_Short_Name [] [Term] id: ARO:3007471 name: narasin namespace: antibiotic_resistance def: "Narasin is polyether ionophore antibiotic. It is a derivative of salinomycin with an additional methyl group. Narasin is produced by fermentation of a strain of Streptomyces aureofaciens." [PMID:37119567] is_a: ARO:3005163 ! ionophore with antibiotic activity xref: pubchem.compound:65452 [Term] id: ARO:3007472 name: tilmicosin namespace: antibiotic_resistance def: "Tilmicosin is a macrolide antibiotic used for livestock and poultry synthesized from tylomycin. It is mainly used to treat common bacterial infections and diseases caused by mycoplasma infection in livestock and poultry breeding. Tilmicosin has broad-spectrum antibacterial properties and has a strong inhibitory effect on most Gram positive and negative bacteria." [PMID:37110187] is_a: ARO:0000000 ! macrolide antibiotic xref: pubchem.compound:5282521 [Term] id: ARO:3007473 name: Mycobacterium avium gyrA with mutation conferring resistance to Fluoroquinolone namespace: antibiotic_resistance def: "Amino acid substitution mutations in Mycobacterium avium gyrA observed to confer resistance to fluoroquinolone antibiotics." [PMID:37067420] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:0000074 ! moxifloxacin synonym: "Mavi_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3007474 name: contezolid namespace: antibiotic_resistance def: "Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of multidrug-resistant (MDR) Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci." [PMID:36992830] is_a: ARO:3000079 ! oxazolidinone antibiotic xref: pubchem.compound:25184541 [Term] id: ARO:3007475 name: cefcapene namespace: antibiotic_resistance def: "Cefcapene is a third-generation cephalosporin in the beta-lactam class of antibiotics used to manage and treat gram-negative and gram-positive bacterial infections." [PMID:36872372] is_a: ARO:0000032 ! cephalosporin xref: pubchem.compound:6436055 [Term] id: ARO:3007476 name: Mycobacterium abscessus atpE with mutation conferring resistance to bedaquiline namespace: antibiotic_resistance def: "Mutations to the ATPase subunit C atpE gene, which is involved with the production of ATP, confer resistance to bedaquiline by altering the antibiotic's target." [PMID:36988496] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant is_a: ARO:3007477 ! antibiotic resistant ATP synthase relationship: confers_resistance_to_antibiotic ARO:3004492 ! bedaquiline synonym: "Mabs_atpE_BDQ" EXACT CARD_Short_Name [] [Term] id: ARO:3007477 name: antibiotic resistant ATP synthase namespace: antibiotic_resistance def: "ATP synthase enzymes, specifically subunit C, resistant to diarylquinolone antibiotics including Bedaquiline. Mutations in ATP synthase confer antibiotic resistance by disrupting binding and blocking of ATP synthase reactions by Bedaquiline." [PMID:36988496] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3004491 ! diarylquinoline antibiotic [Term] id: ARO:3007478 name: darobactin A namespace: antibiotic_resistance def: "Darobactin A, isolated from Photorhabdus bacteria, contains a macrocyclic peptide-based ring system and exhibits selective antibiotic activity against Gram-negative pathogens in both in vitro and animal infection models and functions." [PMID:35926121] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:155899183 [Term] id: ARO:3007479 name: caprazamycin namespace: antibiotic_resistance def: "Caprazamycin is a potent anti-mycobacterial liponucleoside antibiotics isolated from Streptomyces sp." [PMID:36697788] is_a: ARO:3000034 ! nucleoside antibiotic xref: pubchem.compound:11332272 [Term] id: ARO:3007480 name: TBI-223 namespace: antibiotic_resistance def: "TBI-223 is a novel oxazolidinone with potentially reduced myelosuppression, compared to linezolid. TBI-223 may be considered an additional treatment against MRSA infections and potentially other Gram-positive bacteria in humans." [PMID:36106881] is_a: ARO:3000079 ! oxazolidinone antibiotic xref: pubchem.compound:126494519 [Term] id: ARO:3007481 name: pseudouridimycin namespace: antibiotic_resistance def: "Pseudouridimycin is a nucleoside analogue inhibitor discovered from the soil bacterium Streptomyces sp. which has proven to be effective against multidrug-resistant S. pyogenes." [PMID:36873015] is_a: ARO:3000034 ! nucleoside antibiotic xref: pubchem.compound:72792467 [Term] id: ARO:3007482 name: RAD beta-lactamase namespace: antibiotic_resistance def: "RAD beta-lactamases are a class D beta-lactamase first identified in Riemerella anatipestifer." [] is_a: ARO:3000075 ! class D beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin [Term] id: ARO:3007483 name: RAD-1 namespace: antibiotic_resistance def: "RAD-1 is a class D RAD beta-lactamase found in Riemerella anatipestifer." [PMID:36883515] is_a: ARO:3007482 ! RAD beta-lactamase synonym: "RAD-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007484 name: monensin namespace: antibiotic_resistance def: "Monensin is an ionophore antibiotic isolated from Streptomyces cinnamonensis with very strong antibacterial and antiparasitic effects." [PMID:37219624] is_a: ARO:3005163 ! ionophore with antibiotic activity xref: pubchem.compound:441145 [Term] id: ARO:3007485 name: nigericin namespace: antibiotic_resistance def: "Nigericin is an antibiotic derived from Streptomyces hygroscopicus. It is described as a potassium ionophore, which facilitates H+/K+ anti-port across cell membranes, thereby activating NLRP3 by causing potassium efflux." [PMID:37247906] is_a: ARO:3005163 ! ionophore with antibiotic activity xref: pubchem.compound:34230 [Term] id: ARO:3007486 name: wychimicin namespace: antibiotic_resistance def: "Wychimicins are spirotetronates with activity against methicillin-resistant Staphylococcus aureus." [PMID:36071214] is_a: ARO:3005171 ! polyketide with antibiotic activity [Term] id: ARO:3007487 name: wychimicin A namespace: antibiotic_resistance def: "Wychimicin A is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4." [PMID:36071214] is_a: ARO:3007486 ! wychimicin xref: pubchem.compound:165412942 [Term] id: ARO:3007488 name: wychimicin C namespace: antibiotic_resistance def: "Wychimicin C is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4." [PMID:36071214] is_a: ARO:3007486 ! wychimicin xref: pubchem.compound:165412941 [Term] id: ARO:3007489 name: dfrB10 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene found on a mega-plasmid (0.4 Mb) from a Pseudomonas putida strain." [PMID:26679251] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrB10" EXACT CARD_Short_Name [] [Term] id: ARO:3007490 name: dfrB11 namespace: antibiotic_resistance def: "A dihydrofolate reductase and trimethoprim resistance gene found in a groundwater sample at the Horonobe Underground Research laboratory in Japan in 2017, in a Betaproteobacteria sequence." [PMID:28350393] is_a: ARO:3001218 ! trimethoprim resistant dihydrofolate reductase dfr relationship: confers_resistance_to_antibiotic ARO:3000188 ! trimethoprim synonym: "dfrB11" EXACT CARD_Short_Name [] [Term] id: ARO:3007491 name: Pseudomonas aeruginosa ampR with mutation conferring resistance to aztreonam namespace: antibiotic_resistance def: "ampR is a regulatory gene that plays an essential role in regulating antibiotic resistance in P. aeruginosa. Mutation in ampR leads to its loss of control over blaPDC-16, allowing overexpression of blaPDC-16 and further resistance to aztreonam." [PMID:37070974] is_a: ARO:3004232 ! ampC-type beta-lactamase relationship: confers_resistance_to_antibiotic ARO:3000550 ! aztreonam relationship: regulates ARO:3006538 ! PDC-16 synonym: "Paer_ampR_ATM" EXACT CARD_Short_Name [] [Term] id: ARO:3007492 name: tet(62) namespace: antibiotic_resistance def: "A novel tetA-type efflux pump." [PMID:33515651] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline synonym: "tet(62)" EXACT CARD_Short_Name [] [Term] id: ARO:3007493 name: tet(63) namespace: antibiotic_resistance def: "A tetracycline efflux MFS Transporter from Staphylococcus aureus." [PMID:33247717] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline synonym: "tet(63)" EXACT CARD_Short_Name [] [Term] id: ARO:3007494 name: tet(64) namespace: antibiotic_resistance def: "A tetracycline efflux MFS Transporter from Burkholderia ubonensis." [PMID:33318011] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:0000069 ! doxycycline synonym: "tet(64)" EXACT CARD_Short_Name [] [Term] id: ARO:3007495 name: azole antibiotic namespace: antibiotic_resistance def: "Azoles are a group of antibiotics, particularly antifungals, that target the cytochrome P450 enzyme sterol 14alpha-demethylase, which converts lanosterol to ergosterol. They are typically fungistatic in yeasts and fungicidal in molds. The two main groups of azoles are imidazoles and triazoles." [PMID:32906036] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007496 name: echinocandin antibiotic namespace: antibiotic_resistance def: "Echinocandins are a group of antibiotics, particularly antifungals, that target the target glucan synthase, an enzyme involved in the cell wall biosynthesis of fungi. They typically induce adaptive mechanisms that promote resistance such as heat shock protein 90, cell wall integrity pathway, high osmolarity glycerol pathway, and chitin biosynthesis. The three main echinocandins are caspofungin, micafungin and anidulafungin." [PMID:4613708] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007497 name: polyene antibiotic namespace: antibiotic_resistance def: "Polyenes are a group of antibiotics, particularly antifungals, that bind ergosterol, a fungal-specific sterol in the plasma membrane of fungi, causing the efflux of potassium and cell death. They were discovered in the 1930s by Richard Kuhn. They are primarily used for therapy for invasive fungal infections like invasive aspergillosis, cryptococcosis blastomycosis, etc. The two main polyenes are amphotericin B and nystatin." [PMID:33261213] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007498 name: allylamine antibiotic namespace: antibiotic_resistance def: "Allylamines are a group of antibiotics, particularly antifungals, that act as squalene epoxidase and ergosterol inhibitors. They have broad-spectrum activity against pathogenic fungi, especially dermatophytes. The two main allylamines are naftifine and terbinafine." [PMID:1822408, PMID:2229523] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007499 name: triazole antibiotic namespace: antibiotic_resistance def: "Triazoles are a group of antibiotics, particularly antifungals, derived from azoles. Triazoles include fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole." [PMID:35547394] is_a: ARO:3007495 ! azole antibiotic [Term] id: ARO:3007500 name: imidazole antibiotic namespace: antibiotic_resistance def: "Imidazoles are a group of antibiotics, particularly antifungals, derived from azoles. Imidazoles include imidazole derivatives clotrimazole, ketoconazole, miconazole, econazole and oxiconazole." [PMID:18366001, PMID:7003674] is_a: ARO:3007495 ! azole antibiotic [Term] id: ARO:3007501 name: caspofungin namespace: antibiotic_resistance def: "Caspofungin is an antibiotic, particularly antifungal, derived from echinocandins. It has a wide range of activity against fungi and yeasts." [PMID:11465873] is_a: ARO:3007496 ! echinocandin antibiotic xref: pubchem.compound:3035406 [Term] id: ARO:3007502 name: micafungin namespace: antibiotic_resistance def: "Micafungin is an antibiotic, particularly antifungal, derived from echinocandins. It was discovered at Fujisawa Pharmaceutical Co., Ltd. It is active against most Candida species." [PMID:18424132] is_a: ARO:3007496 ! echinocandin antibiotic xref: pubchem.compound:477468 [Term] id: ARO:3007503 name: anidulafungin namespace: antibiotic_resistance def: "Anidulafungin is an antibiotic, particularly antifungal, derived from echinocandins. It exhibits strong antifungal action against a variety of Candida spp. and Aspergillus spp., including those that are resistant to amphotericin B and triazole." [PMID:15456342] is_a: ARO:3007496 ! echinocandin antibiotic xref: pubchem.compound:166548 [Term] id: ARO:3007504 name: amphotericin B namespace: antibiotic_resistance def: "Amphotericin B is an antibiotic, particularly antifungal, derived from polyene. It exhibits strong antifungal action against a variety of fungi species and is typically considered the gold standard of antifungals." [PMID:33523419] is_a: ARO:3007497 ! polyene antibiotic xref: pubchem.compound:5280965 [Term] id: ARO:3007505 name: nystatin namespace: antibiotic_resistance def: "Nystatin is an antibiotic, particularly antifungal, derived from polyene. Nystatin is fungistatic in vitro against Candida albicans and certain other yeast-like fungi." [PMID:4919155] is_a: ARO:3007497 ! polyene antibiotic xref: pubchem.compound:6433272 [Term] id: ARO:3007506 name: naftifine namespace: antibiotic_resistance def: "Naftifine is an antibiotic, particularly antifungal, derived from Allylamine. It was discovered in 19742 at the Sandoz Research Institute in Vienna, Austria. Naftifine is fungicidal against a broad spectrum of dermatophyte fungi and provides good against Candida and Aspergillus species." [PMID:1723367, PMID:18346400] is_a: ARO:3007498 ! allylamine antibiotic xref: pubchem.compound:47641 [Term] id: ARO:3007507 name: terbinafine namespace: antibiotic_resistance def: "Terbinafine is an antibiotic, particularly antifungal, derived from allylamine. Terbinafine is active against a broad range of fungi and yeast. It was discovered in 1983." [PMID:1372222] is_a: ARO:3007498 ! allylamine antibiotic xref: pubchem.compound:1549008 [Term] id: ARO:3007508 name: fluconazole namespace: antibiotic_resistance def: "Fluconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of superficial and systemic fungal infections." [PMID:8448970, PMID:10830059] is_a: ARO:3007499 ! triazole antibiotic xref: pubchem.compound:3365 [Term] id: ARO:3007509 name: Shigella flexneri acrA namespace: antibiotic_resistance def: "AcrA is a subunit of the AcrAB multidrug efflux system found in Shigella flexneri, which is encoded by the acrRAB operon." [PMID:19035770] is_a: ARO:3000207 ! acrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin synonym: "Sfle_acrA" EXACT CARD_Short_Name [] [Term] id: ARO:3007511 name: itraconazole namespace: antibiotic_resistance def: "Itraconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida and Malassezia species and Dermatophytes." [PMID:2561187] is_a: ARO:3007499 ! triazole antibiotic xref: pubchem.compound:55283 [Term] id: ARO:3007512 name: voriconazole namespace: antibiotic_resistance def: "Voriconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of invasive aspergillosis, candidaemia, and infections caused by Candida spp." [PMID:16278744] is_a: ARO:3007499 ! triazole antibiotic xref: pubchem.compound:71616 [Term] id: ARO:3007513 name: posaconazole namespace: antibiotic_resistance def: "Posaconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida albicans and Aspergillus fumigatus." [PMID:10898669] is_a: ARO:3007499 ! triazole antibiotic xref: pubchem.compound:468595 [Term] id: ARO:3007514 name: isavuconazole namespace: antibiotic_resistance def: "Isavuconazole is a type of triazole antibiotic, particularly antifungal. It has activity against yeasts, dimorphic fungi, and molds." [PMID:16284102] is_a: ARO:3007499 ! triazole antibiotic xref: pubchem.compound:6918485 [Term] id: ARO:3007515 name: ANT(9)-Ic namespace: antibiotic_resistance def: "ANT(9)-Ic encodes an intrinsic, chromosomal aminoglycoside nucleotidyltransferase in Brucella intermedia." [PMID:37039640] is_a: ARO:3000228 ! ANT(9) is_a: ARO:3007400 ! ANT(9)-I relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "ANT(9)-Ic" EXACT CARD_Short_Name [] [Term] id: ARO:3007516 name: clotrimazole namespace: antibiotic_resistance def: "Clotrimazole is a type of imidazole antibiotic, particularly antifungal. It is mostly used for the treatment of tinea pedis, vulvovaginal and oropharyngeal candidiasis. It has broad activity against Candida albicans and other fungal infections." [PMID:4677595, PMID:5579860] is_a: ARO:3007500 ! imidazole antibiotic xref: pubchem.compound:2812 [Term] id: ARO:3007517 name: ketoconazole namespace: antibiotic_resistance def: "Ketoconazole is a type of imidazole antibiotic, particularly antifungal. It was one of the first available oral broad-spectrum antifungals for the treatment of systemic and superficial mycoses." [PMID:707893, PMID:6276122] is_a: ARO:3007500 ! imidazole antibiotic xref: pubchem.compound:456201 [Term] id: ARO:3007518 name: miconazole namespace: antibiotic_resistance def: "Miconazole is a type of imidazole antibiotic, particularly antifungal. It is used to treat oral and vaginal yeast infections, as well as mucosal thrush." [PMID:4919243, PMID:4563141] is_a: ARO:3007500 ! imidazole antibiotic xref: pubchem.compound:4189 [Term] id: ARO:3007519 name: econazole namespace: antibiotic_resistance def: "Econazole is a type of imidazole antibiotic, particularly antifungal. It is often used to treat tinea cruris, tinea pedis, and tinea corporis." [PMID:1173036, PMID:4417140] is_a: ARO:3007500 ! imidazole antibiotic xref: pubchem.compound:3198 [Term] id: ARO:3007520 name: oxiconazole namespace: antibiotic_resistance def: "Oxiconazole is a type of imidazole antibiotic, particularly antifungal. It is primarily used to treat tinea pedis, tinea cruris, tinea corporis, and tinea versicolor." [PMID:583212, PMID:7037014] is_a: ARO:3007500 ! imidazole antibiotic xref: pubchem.compound:5353853 [Term] id: ARO:3007521 name: flumequine namespace: antibiotic_resistance def: "Flumequine is a first generation fluoroquinolone antibiotic. It is used primarily for the treatment of enteric infections in domestic species. It has been removed from clinical use and is no longer being marketed." [PMID:34729090] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:3374 [Term] id: ARO:3007522 name: antifungal-resistant cytochrome P450 enzyme namespace: antibiotic_resistance def: "Fungal cytochrome P450 enzymes which include mutations or other modifications to confer resistance to antifungal drug compounds." [PMID:28176517] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3007523 name: triazole-resistant fungal cytochrome P450 enzyme namespace: antibiotic_resistance def: "Fungal cytochrome P450 enzymes which include mutations to confer resistance to triazole-class antibiotics." [PMID:28176517] is_a: ARO:3007522 ! antifungal-resistant cytochrome P450 enzyme relationship: confers_resistance_to_drug_class ARO:3007499 ! triazole antibiotic [Term] id: ARO:3007524 name: Candida spp. ERG11 with mutations conferring resistance to azole antibiotics namespace: antibiotic_resistance def: "ERG11 is a cytochrome P450 enzyme in Candida spp. Mutations in ERG11 have been shown to confer resistance to azole antibiotics including fluconazole and itraconazole." [PMID:35163552, PMID:28176517] is_a: ARO:3007523 ! triazole-resistant fungal cytochrome P450 enzyme relationship: confers_resistance_to_antibiotic ARO:3007508 ! fluconazole relationship: confers_resistance_to_antibiotic ARO:3007511 ! itraconazole relationship: confers_resistance_to_antibiotic ARO:3007512 ! voriconazole relationship: derives_from ARO:3007608 ! antibiotic susceptible ERG11 [Term] id: ARO:3007525 name: norvancomycin namespace: antibiotic_resistance def: "Norvancomycin differs from vancomycin by a single methyl group and is typically used to treat methicillin-resistant Staphylococcus aureus (MRSA) ventriculitis in patients." [PMID:36823383] is_a: ARO:3000081 ! glycopeptide antibiotic xref: pubchem.compound:10419027 [Term] id: ARO:3007526 name: spectinomycin resistant rpsE namespace: antibiotic_resistance def: "Amino acid substitutions in ribosomal protein S5, the product of the rpsE gene, is associated with resistance to spectinomycin (SpcR). This protein is located on the 30S subunit and interacts with 16S rRNA and other proteins." [] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:0000016 ! aminoglycoside antibiotic synonym: "Ribosomal protein S5" EXACT [] [Term] id: ARO:3007527 name: Bacillus subtilis rpsE mutations conferring resistance to spectinomycin namespace: antibiotic_resistance def: "Amino acid substitutions in ribosomal protein S5, rpsE, is associated with resistance to spectinomycin (SpcR)." [PMID:34339280] is_a: ARO:3007526 ! spectinomycin resistant rpsE relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "Bsub_rpsE_SPT" EXACT CARD_Short_Name [] [Term] id: ARO:3007528 name: gallic acid namespace: antibiotic_resistance def: "Gallic acid was found to enhance sulfonamides against multidrug-resistant S. suis. Gallic acid effectively disrupts the integrity and function of the cytoplasmic membrane by dissipating the proton motive force of bacteria. It regulates the expression of dihydrofolate reductase, which then inhibits tetrahydrofolate synthesis. As a result of polypharmacology, gallic acid can fully restore sulfadiazine sodium activity in the animal infection model without any drug resistances." [PMID:37125728] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:370 [Term] id: ARO:3007529 name: pivmecillinam namespace: antibiotic_resistance def: "Pivmecillinam, the oral prodrug of the antimicrobial active agent mecillinam, is a bona fide agent for uncomplicated lower urinary tract infections (UTIs), because of its selectivity and effect against several species of Enterobacteriaceae." [PMID:31067667] is_a: ARO:3000008 ! penam synonym: "amdinocillin pivoxil" EXACT [] xref: pubchem.compound:115163 [Term] id: ARO:3007530 name: Streptococcus pyogenes PBP2x with mutation conferring resistance to beta-lactam antibiotics namespace: antibiotic_resistance def: "PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics." [] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics [Term] id: ARO:3007531 name: Streptococcus pyogenes PBP2x conferring resistance to beta-lactam antibiotics namespace: antibiotic_resistance def: "PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics." [PMID:31630171, PMID:36374114] is_a: ARO:3003938 ! Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000645 ! cefotaxime synonym: "Spyo_PBP2x_BLA" EXACT CARD_Short_Name [] [Term] id: ARO:3007532 name: proflavine namespace: antibiotic_resistance def: "Proflavine, also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria." [PMID:36240541] is_a: ARO:3005386 ! disinfecting agents and antiseptics synonym: "diaminoacridine" EXACT [] synonym: "proflavin" EXACT [] xref: pubchem.compound:7099 [Term] id: ARO:3007533 name: MCR-4.7 namespace: antibiotic_resistance def: "An MCR-4-type colistin resistance gene variant." [PMID:37171842] is_a: ARO:3004268 ! MCR phosphoethanolamine transferase relationship: confers_resistance_to_antibiotic ARO:3000622 ! colistin A relationship: confers_resistance_to_antibiotic ARO:3000624 ! colistin B synonym: "MCR-4.7" EXACT CARD_Short_Name [] [Term] id: ARO:3007534 name: arsinothricin namespace: antibiotic_resistance def: "Arsinothricin is a natural product synthesized by the rhizosphere bacterium Burkholderia gladioli GSRB05 and is a broad-spectrum antibiotic effective against human pathogens such as carbapenem-resistant Enterobacter cloacae. It is a non-proteogenic amino acid and glutamate mimetic that inhibits bacterial glutamine synthetase." [PMID:36785875] is_a: ARO:3000551 ! organoarsenic antibiotic [Term] id: ARO:3007535 name: pretomanid namespace: antibiotic_resistance def: "Pretomanid is an antibiotic medication used for the treatment of multi-drug-resistant tuberculosis affecting the lungs." [PMID:36409105] is_a: ARO:3004115 ! nitroimidazole antibiotic xref: pubchem.compound:456199 [Term] id: ARO:3007536 name: Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to amikacin namespace: antibiotic_resistance def: "Point mutation in M. tuberculosis rrnS conferring resistance to amikacin antibiotic." [PMID:37224060] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000049 ! kanamycin A synonym: "Mtub_16rrnS_AMK" EXACT CARD_Short_Name [] [Term] id: ARO:3007537 name: Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to kanamycin namespace: antibiotic_resistance def: "Point mutation in M. tuberculosis rrnS conferring resistance to kanamycin antibiotic." [PMID:37224060] is_a: ARO:3003666 ! 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics relationship: confers_resistance_to_antibiotic ARO:0000013 ! amikacin synonym: "Mtub_16rrnS_KAN" EXACT CARD_Short_Name [] [Term] id: ARO:3007538 name: chenodeoxycholic acid namespace: antibiotic_resistance def: "A cholic acid derivative of the traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, and this synergistic killing was effective against diverse methicillin-resistant S. aureus (MRSA) variants. Mechanistically, chenodeoxycholic acid increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates reactive oxygen species (ROS) generation by inhibiting superoxide dismutase activity." [PMID:36625660] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:10133 [Term] id: ARO:3007539 name: APH(9)-Ic namespace: antibiotic_resistance def: "APH(9)-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia." [PMID:36699730] is_a: ARO:3000153 ! APH(9) relationship: confers_resistance_to_antibiotic ARO:0000039 ! spectinomycin synonym: "APH(9)-Ic" EXACT CARD_Short_Name [] [Term] id: ARO:3007540 name: cyclomarin antibiotics namespace: antibiotic_resistance def: "Cyclomarins are cyclic heptapeptides containing four unusual amino acids. Cyclomarins target two different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), and PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria." [PMID:27241518, PMID:36748577] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007541 name: cyclomarin A namespace: antibiotic_resistance def: "Cyclomarin A was found to be bacteriocidal against bacteria replicating in culture broth and in human-derived macrophages and a series of multidrug resistant clinical isolates. It was identified as a potent antitubercular compound in a natural product whole cell screen. Importantly it kills both growing and dormant, non-replicating mycobacteria." [PMID:36748577, PMID:27241518] is_a: ARO:3007540 ! cyclomarin antibiotics xref: pubchem.compound:10772429 [Term] id: ARO:3007542 name: cyclomarin B namespace: antibiotic_resistance def: "Cyclomarin B is a cyclomarin antibiotic." [PMID:27241518] is_a: ARO:3007540 ! cyclomarin antibiotics xref: pubchem.compound:21593897 [Term] id: ARO:3007543 name: cyclomarin C namespace: antibiotic_resistance def: "Cyclomarin C is a cyclomarin antibiotic." [PMID:27241518] is_a: ARO:3007540 ! cyclomarin antibiotics xref: pubchem.compound:11205419 [Term] id: ARO:3007544 name: Erysipelothrix rhusiopathiae gyrA with mutation conferring resistance to enrofloxacin namespace: antibiotic_resistance def: "Sequence analysis of the gyrA gene showed that resistance of E. rhusiopathiae strains to enrofloxacin is due to a mutation at position 257." [PMID:36986331] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:3007045 ! enrofloxacin synonym: "Erhu_gyrA_ENR" EXACT CARD_Short_Name [] [Term] id: ARO:3007545 name: antifungal-resistant beta-1,3-D-glucan synthase namespace: antibiotic_resistance def: "Fungal beta-1,3-D-glucan synthase enzymes which include mutations to confer resistance to antifungal drug compounds." [PMID:19546367] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3007546 name: echinocandin antibiotic-resistant beta-1,3-D-glucan synthase namespace: antibiotic_resistance def: "Fungal beta-1,3-D-glucan synthases which include mutations to confer resistance to echinocandin-class antibiotics." [PMID:19546367] is_a: ARO:3007545 ! antifungal-resistant beta-1,3-D-glucan synthase relationship: confers_resistance_to_drug_class ARO:3007496 ! echinocandin antibiotic [Term] id: ARO:3007547 name: salinomycin namespace: antibiotic_resistance def: "Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug." [PMID:37276926] is_a: ARO:3005163 ! ionophore with antibiotic activity xref: pubchem.compound:3085092 [Term] id: ARO:3007548 name: Candida spp. FKS2 with mutations conferring resistance to echinocandin antibiotics namespace: antibiotic_resistance def: "Glucan synthase FKS2 is involved in the production of the fungal cell wall by the synthesis of the core component beta-1,3-glucan in Candida spp. Mutations in FKS2 have been shown to confer resistance to echinocandin antibiotic micafungin." [PMID:19546367] is_a: ARO:3007546 ! echinocandin antibiotic-resistant beta-1,3-D-glucan synthase relationship: confers_resistance_to_antibiotic ARO:3007502 ! micafungin [Term] id: ARO:3007549 name: antibiotic resistant ergosterol biosynthesis pathway transcription factor namespace: antibiotic_resistance def: "Fungal sterol regulatory element binding proteins are transcription factors that modulate antibiotic-susceptible genes. Mutations in these proteins confer resistance to antifungal drug compounds through differential gene regulation." [PMID:18487346] is_a: ARO:3007610 ! gene modulating azole resistance relationship: confers_resistance_to_drug_class ARO:3007499 ! triazole antibiotic relationship: participates_in ARO:3007609 ! antibiotic target overexpression [Term] id: ARO:3007551 name: Candida spp. Upc2 with mutations conferring resistance to azole antibiotics namespace: antibiotic_resistance def: "Upc2 is a sterol synthesis regulatory element binding protein in Candida spp. Mutations in Upc2 have been shown to confer resistance to azole antibiotics including fluconazole by upregulating ERG11 expression." [PMID:18487346] is_a: ARO:3007549 ! antibiotic resistant ergosterol biosynthesis pathway transcription factor relationship: confers_resistance_to_antibiotic ARO:3007508 ! fluconazole relationship: regulates ARO:3007608 ! antibiotic susceptible ERG11 [Term] id: ARO:3007552 name: pleiotropic drug resistance transcription factors namespace: antibiotic_resistance def: "Pleiotropic Drug Resistance factors (PDR) are transcription factors in fungi that regulate the expression of genes encoding for efflux pumps causing multidrug resistance." [PMID:15388433, PMID:7614555, PMID:9043118] is_a: ARO:3000451 ! protein(s) and two-component regulatory system modulating antibiotic efflux [Term] id: ARO:3007553 name: Candida spp. CDR1 namespace: antibiotic_resistance def: "CDR1 is a pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp." [PMID:7614555] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3007508 ! fluconazole relationship: confers_resistance_to_antibiotic ARO:3007518 ! miconazole [Term] id: ARO:3007554 name: Candida spp. CDR2 namespace: antibiotic_resistance def: "CDR2 is a Pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp." [PMID:9043118] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3007507 ! terbinafine relationship: confers_resistance_to_antibiotic ARO:3007508 ! fluconazole [Term] id: ARO:3007555 name: Zn2Cys6 transcription factors namespace: antibiotic_resistance def: "Zn2Cys6 is a transcription factor family that includes mutations to confer resistance to azole-class antibiotics." [PMID:16452151] is_a: ARO:3000219 ! mutant efflux regulatory protein conferring antibiotic resistance relationship: confers_resistance_to_drug_class ARO:3007499 ! triazole antibiotic relationship: confers_resistance_to_drug_class ARO:3007500 ! imidazole antibiotic [Term] id: ARO:3007556 name: fungal uracil phosphoribosyltransferase namespace: antibiotic_resistance def: "Fungal uracil phosphoribosyltransferases which include mutations to confer resistance to 5-flucytosine antibiotic." [PMID:15504867] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007560 ! pyrimidine antifungal drug [Term] id: ARO:3007557 name: Candida spp. FUR1 with mutations conferring resistance to 5-flucytosine namespace: antibiotic_resistance def: "FUR1 is a fungal uracil phosphoribosyltransferase in Candida spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine." [PMID:15504867] is_a: ARO:3007556 ! fungal uracil phosphoribosyltransferase relationship: confers_resistance_to_antibiotic ARO:3007558 ! 5-flucytosine [Term] id: ARO:3007558 name: 5-flucytosine namespace: antibiotic_resistance def: "5-Flucytosine is an antibiotic, particularly antifungal. It inhibits fungal RNA and DNA synthesis by changing the amino-acylation of tRNA, causing the amino acid pool to be altered and protein synthesis to be inhibited." [PMID:37051439] is_a: ARO:3007560 ! pyrimidine antifungal drug xref: pubchem.compound:3366 [Term] id: ARO:3007559 name: Saccharomyces spp. FUR1 with mutations conferring resistance to 5-flucytosine namespace: antibiotic_resistance def: "FUR1 is a fungal uracil phosphoribosyltransferase in Saccharomyces spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine." [PMID:2189783] is_a: ARO:3007556 ! fungal uracil phosphoribosyltransferase relationship: confers_resistance_to_antibiotic ARO:3007558 ! 5-flucytosine [Term] id: ARO:3007560 name: pyrimidine antifungal drug namespace: antibiotic_resistance def: "Any pyrimidine antifungal agent that has been used for the treatment of fungal infections in humans or animals." [] is_a: ARO:1000003 ! antibiotic molecule [Term] id: ARO:3007561 name: OXA-1038 namespace: antibiotic_resistance def: "The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis." [PMID:37317299] is_a: ARO:3007721 ! OXA-48-like beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem synonym: "OXA-1038" EXACT CARD_Short_Name [] [Term] id: ARO:3007562 name: OXA-1039 namespace: antibiotic_resistance def: "The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis." [PMID:37317299] is_a: ARO:3007721 ! OXA-48-like beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem synonym: "OXA-1039" EXACT CARD_Short_Name [] [Term] id: ARO:3007563 name: Candida spp. TAC1 with mutations conferring resistance to azole antibiotics namespace: antibiotic_resistance def: "TAC1 is a Zn2Cys6 transcription factor that transcriptionally activates efflux units CDR1 and CDR2. Mutations in TAC1 upregulate CDR1 and CDR2 causing increased resistance." [PMID:16452151] is_a: ARO:3007555 ! Zn2Cys6 transcription factors relationship: regulates ARO:3007553 ! Candida spp. CDR1 relationship: regulates ARO:3007554 ! Candida spp. CDR2 [Term] id: ARO:3007564 name: pH-responsive transcription factors namespace: antibiotic_resistance def: "The pH-dependant transcription factors regulate the expression of antifungal resistance-conferring genes based on the pH of the environment." [PMID:29610197] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_drug_class ARO:3007560 ! pyrimidine antifungal drug [Term] id: ARO:3007565 name: Aspergillus spp. cyp51A with mutations conferring resistance to triazoles antibiotics namespace: antibiotic_resistance def: "Aspergillus spp. cyp51A is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole resistance." [PMID:12604551, PMID:15215142] is_a: ARO:3007523 ! triazole-resistant fungal cytochrome P450 enzyme relationship: confers_resistance_to_antibiotic ARO:3007511 ! itraconazole relationship: confers_resistance_to_antibiotic ARO:3007512 ! voriconazole relationship: confers_resistance_to_antibiotic ARO:3007513 ! posaconazole [Term] id: ARO:3007566 name: Cryptococcus spp. AFR1 namespace: antibiotic_resistance def: "Cryptococcus spp. AFR1 gene is an ABC transporter gene that contributes to antifungal resistance through antibiotic efflux." [PMID:12519188] is_a: ARO:0010001 ! ATP-binding cassette (ABC) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:3007508 ! fluconazole [Term] id: ARO:3007567 name: UDP-glucuronic acid decarboxylase namespace: antibiotic_resistance def: "UDP-glucuronic acid decarboxylase catalyzes the decarboxylation of UDP-glucuronic acid. Accumulation of UDP-glucuronic acid mediates resistance to 5-flucytosine." [PMID:31913284, PMID:34103502] is_a: ARO:3003768 ! gene conferring resistance via absence relationship: confers_resistance_to_drug_class ARO:3007560 ! pyrimidine antifungal drug [Term] id: ARO:3007568 name: Cryptococcus spp. UXS1 conferring resistance to 5-flucytosine via absence namespace: antibiotic_resistance def: "UXS1 is a UDP-glucuronic acid decarboxylase. Deletion of UXS1 confers resistance to 5-flucytosine by accumulation of UDP-glucoronic acid, thereby suppressing the cellular toxicity of 5-flucytosine." [PMID:31913284, PMID:34103502] is_a: ARO:3007567 ! UDP-glucuronic acid decarboxylase relationship: confers_resistance_to_antibiotic ARO:3007558 ! 5-flucytosine [Term] id: ARO:3007569 name: BIOMIC Microbiology System namespace: antibiotic_resistance def: "Specific automated system of analysis for determining antimicrobial susceptibility developed by Giles Scientific." [] is_a: ARO:3004398 ! automated testing platform [Term] id: ARO:3007570 name: Mycaminosyltylonolide namespace: antibiotic_resistance def: "Mycaminosyltylonolide is a tylosin derivative with promising anti- P. aeruginosa activity, especially when combined with other antibiotics such as polymixin B." [PMID:37208456] is_a: ARO:0000000 ! macrolide antibiotic synonym: "5-O-mycaminosyltylonolide" EXACT [] xref: pubchem.compound:6437420 [Term] id: ARO:3007571 name: cefquinome namespace: antibiotic_resistance def: "Cefquinome is a fourth-generation cephalosporin with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections." [PMID:37280708] is_a: ARO:0000032 ! cephalosporin xref: pubchem.compound:5464355 [Term] id: ARO:3007572 name: cinnamaldehyde namespace: antibiotic_resistance def: "Cinnamaldehyde was found to enhance the antibacterial activity of ceftriaxone sodium against MDR Salmonella in vitro by significantly reducing the expression of extended-spectrum beta-lactamase, inhibiting the development of drug resistance under ceftriaxone selective pressure in vitro, damaging the cell membrane, and affecting its basic metabolism." [PMID:37298240] is_a: ARO:3007223 ! adjuvants enhancing antibiotic entry xref: pubchem.compound:637511 [Term] id: ARO:3007573 name: fasamycin namespace: antibiotic_resistance def: "Fasamycins and congeners are a class of rare aromatic polyketides possessing a partially reduced 1-phenyltetracene pentacyclic core." [PMID:37327570] is_a: ARO:3005171 ! polyketide with antibiotic activity [Term] id: ARO:3007574 name: formicamycin namespace: antibiotic_resistance def: "The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5, which produces the compounds at low levels." [PMID:33440167] is_a: ARO:3005171 ! polyketide with antibiotic activity [Term] id: ARO:3007575 name: fasamcyin A namespace: antibiotic_resistance def: "Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF." [PMID:37327570] is_a: ARO:3007573 ! fasamycin xref: pubchem.compound:57404528 [Term] id: ARO:3007576 name: fasamcyin B namespace: antibiotic_resistance def: "Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF." [PMID:37327570] is_a: ARO:3007573 ! fasamycin xref: pubchem.compound:57404257 [Term] id: ARO:3007577 name: fasamcyin G namespace: antibiotic_resistance def: "Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF." [PMID:37327570] is_a: ARO:3007573 ! fasamycin xref: pubchem.compound:156016388 [Term] id: ARO:3007578 name: fasamcyin H namespace: antibiotic_resistance def: "Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF." [PMID:37327570] is_a: ARO:3007573 ! fasamycin xref: pubchem.compound:156017923 [Term] id: ARO:3007579 name: fasamcyin I namespace: antibiotic_resistance def: "Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF." [PMID:37327570] is_a: ARO:3007573 ! fasamycin xref: pubchem.compound:156012442 [Term] id: ARO:3007580 name: fasamcyin J namespace: antibiotic_resistance def: "Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF." [PMID:37327570] is_a: ARO:3007573 ! fasamycin xref: pubchem.compound:156017733 [Term] id: ARO:3007581 name: fasamcyin K namespace: antibiotic_resistance def: "Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF." [PMID:37327570] is_a: ARO:3007573 ! fasamycin xref: pubchem.compound:156581097 [Term] id: ARO:3007582 name: formicamycin A namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684581 [Term] id: ARO:3007583 name: formicamycin B namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684582 [Term] id: ARO:3007584 name: formicamycin C namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684583 [Term] id: ARO:3007585 name: formicamycin E namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684585 [Term] id: ARO:3007586 name: formicamycin M namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684593 [Term] id: ARO:3007587 name: formicamycin O namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:156020171 [Term] id: ARO:3007588 name: formicamycin L namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684592 [Term] id: ARO:3007589 name: formicamycin F namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684586 [Term] id: ARO:3007590 name: formicamycin P namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:156011794 [Term] id: ARO:3007591 name: formicamycin G namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684587 [Term] id: ARO:3007592 name: formicamycin D namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684584 [Term] id: ARO:3007593 name: formicamycin N namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:156010277 [Term] id: ARO:3007594 name: formicamycin H namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684588 [Term] id: ARO:3007595 name: formicamycin Q namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:156018422 [Term] id: ARO:3007596 name: formicamycin I namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684589 [Term] id: ARO:3007597 name: formicamycin J namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684590 [Term] id: ARO:3007598 name: formicamycin K namespace: antibiotic_resistance def: "Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates." [PMID:33440167] is_a: ARO:3007574 ! formicamycin xref: pubchem.compound:146684591 [Term] id: ARO:3007599 name: propolis namespace: antibiotic_resistance def: "Propolis has a significant synergistic effect in combination with ciprofloxacin, erythromycin, and gentamycin. It has a potent inhibitory activity toward the S. aureus (MRS USA300) pump system." [PMID:36777436] is_a: ARO:3007224 ! adjuvants inhibiting antibiotic removal xref: pubchem.compound:11148893 [Term] id: ARO:3007600 name: cervimycin namespace: antibiotic_resistance def: "The polyketide antibiotics cervimycins are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-resistant staphylococci and vancomycin-resistant enterococci." [PMID:36173303] is_a: ARO:3005171 ! polyketide with antibiotic activity [Term] id: ARO:3007601 name: cervimycin A namespace: antibiotic_resistance def: "Cervimycins are polyketide antibiotics." [PMID:36173303] is_a: ARO:3007600 ! cervimycin xref: pubchem.compound:11557219 [Term] id: ARO:3007602 name: cervimycin B namespace: antibiotic_resistance def: "Cervimycins are polyketide antibiotics." [PMID:36173303] is_a: ARO:3007600 ! cervimycin xref: pubchem.compound:11693822 [Term] id: ARO:3007603 name: cervimycin C namespace: antibiotic_resistance def: "Cervimycins are polyketide antibiotics." [PMID:36173303] is_a: ARO:3007600 ! cervimycin xref: pubchem.compound:54687465 [Term] id: ARO:3007604 name: cervimycin D namespace: antibiotic_resistance def: "Cervimycins are polyketide antibiotics." [PMID:36173303] is_a: ARO:3007600 ! cervimycin xref: pubchem.compound:54677926 [Term] id: ARO:3007605 name: cervimycin K1 namespace: antibiotic_resistance def: "Cervimycins are polyketide antibiotics." [PMID:36173303] is_a: ARO:3007600 ! cervimycin xref: pubchem.compound:54726226 [Term] id: ARO:3007606 name: cervimycin K2 namespace: antibiotic_resistance def: "Cervimycins are polyketide antibiotics." [PMID:36173303] is_a: ARO:3007600 ! cervimycin xref: pubchem.compound:54579611 [Term] id: ARO:3007607 name: cervimycin N namespace: antibiotic_resistance def: "Cervimycins are polyketide antibiotics." [PMID:36173303] is_a: ARO:3007600 ! cervimycin xref: pubchem.compound:54726225 [Term] id: ARO:3007608 name: antibiotic susceptible ERG11 namespace: antibiotic_resistance def: "ERG11 is a cytochrome P450 enzyme in Candida species that is not functional when bound by azole antibiotics including fluconazole and itraconazole. However, high levels of ERG11 expression can overcome effective azole doses." [PMID:18487346, PMID:35163552] is_a: ARO:3000709 ! cell wall synthesis enzyme targeted by antibiotic [Term] id: ARO:3007609 name: antibiotic target overexpression namespace: antibiotic_resistance def: "Increased expression of an antibiotic target protein can overcome effective dose of an antibiotic, leading to reduced susceptibility." [] is_a: ARO:1000002 ! mechanism of antibiotic resistance [Term] id: ARO:3007610 name: gene modulating azole resistance namespace: antibiotic_resistance def: "Genes that directly or indirectly modulate azole resistance." [] is_a: ARO:3000000 ! determinant of antibiotic resistance [Term] id: ARO:3007611 name: sarafloxacin namespace: antibiotic_resistance def: "Sarafloxacin is used for treatment and control of bacterial infections in poultry caused by Escherichia coli and Salmonella spp. It was removed from the market by manufacturers in 2001." [PMID:37250042] is_a: ARO:0000001 ! fluoroquinolone antibiotic xref: pubchem.compound:56208 [Term] id: ARO:3007612 name: hinokitiol namespace: antibiotic_resistance def: "Hinokitiol (beta-thujaplicin), a natural tropolone derivative found in the heartwood of cupressaceous plants, has been widely used in oral and skin care products as an antimicrobial agent, specifically to enhance tetracyclines against Staphylococcus aureus." [PMID:36943047] is_a: ARO:3007224 ! adjuvants inhibiting antibiotic removal xref: pubchem.compound:3611 [Term] id: ARO:3007613 name: totoral namespace: antibiotic_resistance def: "The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Totoral acts as a NorA efflux pump inhibitor as well as an antistaphylococcal antimicrobial agent." [PMID:17664318] is_a: ARO:3007224 ! adjuvants inhibiting antibiotic removal is_a: ARO:3007325 ! inhibitors of NorA efflux pump xref: pubchem.compound:92783 [Term] id: ARO:3007614 name: resveratrol namespace: antibiotic_resistance def: "Resveratrol is a naturally occurring polyphenolic compound that is produced by many different plants, displays antioxidant properties, and protects macromolecules against damage by reactive oxygen species. ATP synthase inhibition with resveratrol can enhance the activity of aminoglycosides against S. aureus and potentially against other bacterial pathogens." [PMID:29906565] is_a: ARO:3005025 ! ATP synthase inhibitor xref: pubchem.compound:445154 [Term] id: ARO:3007615 name: pyrrolomycin antibiotic namespace: antibiotic_resistance def: "Pyrrolomycins are protonophore antibiotics produced by Actinosporangium and Streptomyces. The mechanism of their antimicrobial activity consists in depolarization of bacterial membrane, leading to the suppression of bacterial bioenergetics through the uncoupling of oxidative phosphorylation." [PMID:36171648] is_a: ARO:3005163 ! ionophore with antibiotic activity [Term] id: ARO:3007616 name: pyrrolomycin A namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:133275 [Term] id: ARO:3007617 name: pyrrolomycin B namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:133274 [Term] id: ARO:3007618 name: pyrrolomycin C namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:133779 [Term] id: ARO:3007619 name: pyrrolomycin D namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:133780 [Term] id: ARO:3007620 name: pyrrolomycin E namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:5487782 [Term] id: ARO:3007621 name: pyrrolomycin F namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:3086276 [Term] id: ARO:3007622 name: pyrrolomycin F2a namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:181928 [Term] id: ARO:3007623 name: pyrrolomycin F2b namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:102115511 [Term] id: ARO:3007624 name: pyrrolomycin G namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:11360758 [Term] id: ARO:3007625 name: pyrrolomycin H namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:11303705 [Term] id: ARO:3007626 name: pyrrolomycin F3 namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:102115512 [Term] id: ARO:3007627 name: pyrrolomycin I namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:11772125 [Term] id: ARO:3007628 name: pyrrolomycin J namespace: antibiotic_resistance def: "Pyrrolomycins are protonophores with antibiotic activity." [PMID:36171648] is_a: ARO:3007615 ! pyrrolomycin antibiotic xref: pubchem.compound:11337778 [Term] id: ARO:3007629 name: cadaside antibiotic namespace: antibiotic_resistance def: "The cadasides are calcium-dependent cyclic acidic lipopeptide antibiotics that disrupt cell wall biosynthesis and show activity against multiple drug-resistant Gram-positive pathogens." [PMID:36168660] is_a: ARO:3000035 ! lipopeptide antibiotic [Term] id: ARO:3007630 name: cadaside A namespace: antibiotic_resistance def: "Cadasides are lipopeptides with antibiotic activity." [PMID:36168660] is_a: ARO:3007629 ! cadaside antibiotic xref: pubchem.compound:146682091 [Term] id: ARO:3007631 name: cadaside B namespace: antibiotic_resistance def: "Cadasides are lipopeptides with antibiotic activity." [PMID:36168660] is_a: ARO:3007629 ! cadaside antibiotic xref: pubchem.compound:146682092 [Term] id: ARO:3007632 name: FRI-11 namespace: antibiotic_resistance def: "FRI-11 is a FRI-type carbapenem-hydrolyzing class A beta-lactamase." [PMID:36773190] is_a: ARO:3004796 ! FRI beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000070 ! ertapenem relationship: confers_resistance_to_antibiotic ARO:0000073 ! meropenem relationship: confers_resistance_to_antibiotic ARO:3000170 ! imipenem synonym: "FRI-11" EXACT CARD_Short_Name [] [Term] id: ARO:3007633 name: KPC-125 namespace: antibiotic_resistance def: "KPC-125 is a KPC-type class A beta-lactamase. KPC-125 is a variant of KPC-3, differing by a D179A polymorphism within the omega-loop region." [PMID:36112395] is_a: ARO:3000059 ! KPC beta-lactamase relationship: evolutionary_variant_of ARO:3002313 ! KPC-3 synonym: "KPC-125" EXACT CARD_Short_Name [] [Term] id: ARO:3007634 name: CAE beta-lactamase namespace: antibiotic_resistance def: "CAE beta-lactamases are a novel class A serine beta-lactamase family first isolated from Comamonas aquatica." [PMID:36869066] is_a: ARO:3000078 ! class A beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007635 name: CAE-1 namespace: antibiotic_resistance def: "CAE-1 is a CAE beta-lactamase and confers resistance to ampicillin, piperacillin, cefazolin, cefuroxime, and ceftriaxone, and elevates the MIC of ampicillin-sulbactam two-fold in Escherichia coli DH5alpha, suggesting that CAE-1 functions as a broad-spectrum beta-lactamase." [PMID:36869066] is_a: ARO:3007634 ! CAE beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone relationship: confers_resistance_to_antibiotic ARO:0000063 ! cefuroxime relationship: confers_resistance_to_antibiotic ARO:0000078 ! piperacillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin synonym: "CAE-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007636 name: iboxamycin namespace: antibiotic_resistance def: "Iboxamycin is a fully synthetic lincosamide antibiotic. Like other lincosamides, it selectively targets the bacterial ribosome and prevents elongation of the peptide chain. Iboxamycin has been shown to be effective against bacterial strains otherwise resistant to licosamide antibiotics." [PMID:34707295] is_a: ARO:0000017 ! lincosamide antibiotic xref: pubchem.compound:156613433 [Term] id: ARO:3007637 name: Clostridioides difficile cplR namespace: antibiotic_resistance def: "CplR is an ABC-F ATPase ribosomal protection protein from Clostridioides difficile which confers resistance to pleuromutilins and lincosamides. Its resistance to these antibiotics increases in synergy with erythromcyin resistance methylases (e.g., ermB)." [PMID:36951104] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3007636 ! iboxamycin relationship: confers_resistance_to_antibiotic ARO:3007639 ! A201A synonym: "cplR" EXACT CARD_Short_Name [] [Term] id: ARO:3007638 name: hygromycin A namespace: antibiotic_resistance def: "Hygromycin A is an antibiotic produced by Streptomyces hygroscopicus. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. Not to confused with Hygromycin B, which is structurally distinct." [PMID:26028538] is_a: ARO:3000003 ! antibiotic without defined classification synonym: "totomycin" EXACT [] xref: pubchem.compound:6433481 [Term] id: ARO:3007639 name: A201A namespace: antibiotic_resistance def: "A201A is a nucleoside antibiotic. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site." [PMID:26028538] is_a: ARO:3000080 ! aminonucleoside antibiotic xref: pubchem.compound:6441582 [Term] id: ARO:3007640 name: Candida spp. pleiotropic drug resistance factor 1 namespace: antibiotic_resistance def: "PDR1 is a transcription factor that regulates the expression of several genes encoding ABC transporters, contributing to multidrug resistance." [PMID:15388433] is_a: ARO:3007552 ! pleiotropic drug resistance transcription factors relationship: confers_resistance_to_drug_class ARO:3007498 ! allylamine antibiotic relationship: confers_resistance_to_drug_class ARO:3007499 ! triazole antibiotic relationship: confers_resistance_to_drug_class ARO:3007500 ! imidazole antibiotic relationship: regulates ARO:3007553 ! Candida spp. CDR1 relationship: regulates ARO:3007554 ! Candida spp. CDR2 [Term] id: ARO:3007641 name: fungal nucleobase transporters namespace: antibiotic_resistance def: "Fungal nucleobase transporters facilitate the movement of nucleobases across the fungal cell membrane. The absence confers resistance to antibiotics by preventing antibiotic entry into the cell." [PMID:17784857] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_drug_class ARO:3007560 ! pyrimidine antifungal drug [Term] id: ARO:3007642 name: Aspergillus spp. fcyB conferring resistance to 5-flucytosine via reduced permeability namespace: antibiotic_resistance def: "FcyB encodes for purine-cytosine permease in fungal cells. Downregulation or absence of fcyB confers resistance to antibiotics by preventing entry into the cell." [PMID:29610197] is_a: ARO:3007641 ! fungal nucleobase transporters relationship: confers_resistance_to_antibiotic ARO:3007558 ! 5-flucytosine [Term] id: ARO:3007643 name: Aspergillus spp. transcription factor pacC namespace: antibiotic_resistance def: "PacC is a pH-responsive transcription factor. It regulates the expression of antibiotic susceptible genes whose absence confers resistance to antibiotics." [PMID:29610197] is_a: ARO:3007564 ! pH-responsive transcription factors relationship: regulates ARO:3007642 ! Aspergillus spp. fcyB conferring resistance to 5-flucytosine via reduced permeability [Term] id: ARO:3007644 name: Clostridium perfringes cplR namespace: antibiotic_resistance def: "CplR is an ABC-F ATPase ribosomal protection protein from Clostridium perfringes which confers resistance to pleuromutilins and lincosamides." [PMID:36951104] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:0000046 ! lincomycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin relationship: confers_resistance_to_antibiotic ARO:3007636 ! iboxamycin synonym: "Cper_cplR" EXACT CARD_Short_Name [] [Term] id: ARO:3007645 name: Clostridium sporogenes cplR namespace: antibiotic_resistance def: "CplR is an ABC-F ATPase ribosomal protection protein from Clostridium sporogenes which confers resistance to pleuromutilins and lincosamides." [PMID:36951104] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin relationship: confers_resistance_to_antibiotic ARO:3007636 ! iboxamycin relationship: confers_resistance_to_antibiotic ARO:3007638 ! hygromycin A synonym: "Cspo_cplR" EXACT CARD_Short_Name [] [Term] id: ARO:3007646 name: Neobacillus vireti vmlR2 namespace: antibiotic_resistance def: "vmlR2 is an ABC-F ATPase ribosomal protection protein from Neobacillus vireti (formerly known as Bacillus vireti). This representative of the ARE2 subfamily has an unusually long linker domain. Confers resistance to some lincosamide and nucleoside antibiotics." [PMID:36951104] is_a: ARO:3007068 ! Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins relationship: confers_resistance_to_antibiotic ARO:3000669 ! virginiamycin M1 relationship: confers_resistance_to_antibiotic ARO:3000671 ! tiamulin relationship: confers_resistance_to_antibiotic ARO:3001314 ! retapamulin relationship: confers_resistance_to_antibiotic ARO:3007636 ! iboxamycin relationship: confers_resistance_to_antibiotic ARO:3007638 ! hygromycin A relationship: confers_resistance_to_antibiotic ARO:3007639 ! A201A [Term] id: ARO:3007647 name: PSZ beta-lactamase namespace: antibiotic_resistance def: "PSZ beta-lactamases are a novel AmpC enzyme gene family, which was found on a strain of Pantoea endophytica isolated from a rabbit in a livestock farm in China. It shows resistance to penicillins and several cephalosporins, and shares the highest amino acid similarity with the function-characterized AmpC enzyme ERH-1." [PMID:37529328] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007648 name: PSZ-1 namespace: antibiotic_resistance def: "PSZ-1 is a PSZ beta-lactamase found in Pantoea endophytica. The gene showed resistance to penicillins and several first-, second-and third-generation cephalosporins as well as aztreonam." [PMID:37529328] is_a: ARO:3007647 ! PSZ beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000058 ! cefazolin relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "PSZ-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007649 name: CDA beta-lactamase namespace: antibiotic_resistance def: "A CDA beta-lactamase was identified as a novel class C enzyme that was phylogenetically and biochemically close to the chromosome-borne beta-lactamases of the genera Enterobacter and Citrobacter." [PMID:25136020] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem [Term] id: ARO:3007650 name: CDA-1 namespace: antibiotic_resistance def: "CDA-1 was recovered from a urine sample and is intermediate or resistant to third-generation cephalosporins and carbapenems. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC beta-lactamase expression combined with porin deficiency accounted for the carbapenem resistance." [PMID:25136020] is_a: ARO:3007649 ! CDA beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin relationship: confers_resistance_to_antibiotic ARO:3003832 ! ticarcillin relationship: confers_resistance_to_antibiotic ARO:3004023 ! ticarcillin-clavulanic acid relationship: confers_resistance_to_antibiotic ARO:3004129 ! cephaloridine synonym: "CDA-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007651 name: carmoisine namespace: antibiotic_resistance def: "Carmoisine is widely used as a food coloring agent. Carmoisine-mediated reduction of biofilm in Pseudomonas aeruginosa is due to its interaction with LasR and interference with the QS system." [PMID:37485898] is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:19118 [Term] id: ARO:3007652 name: lipoxin A4 namespace: antibiotic_resistance def: "Lipoxin A4 is a Specialized Pro-resolving Mediator and has direct effects on P. aeruginosa where it reduced biofilm formation and promoted ciprofloxacin antibiotic efficacy in a static biofilm-forming system. Further studies show lipoxin A4 can help antibiotic efficacy and promote monocyte activity against established P. aeruginosa biofilm formed under hydrodynamic conditions." [PMID:37462621] is_a: ARO:3007225 ! adjuvants which alter physiology synonym: "LxA4" EXACT [] xref: pubchem.compound:5280914 [Term] id: ARO:3007653 name: ascorbic acid namespace: antibiotic_resistance def: "The production of pyocyanin by Pseudomonas aeruginosa increases its virulence, fitness and biofilm formation. Ascorbic acid combined with furanone-30 elevated quorum-sensing inhibition in P. aeruginosa, which was directly associated with significantly reduced virulence, adhesion, aggregation and biofilm formation and enhanced antibiotic-mediated bacterial killing." [PMID:37520362] is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:54670067 [Term] id: ARO:3007654 name: erm(56) namespace: antibiotic_resistance def: "Erm(56) is an Erm ribosomal RNA methyltransferase. Expression of the cloned erm(56) confers resistance to MLSB in T. pyogenes and Escherichia coli." [PMID:37417762] is_a: ARO:3000560 ! Erm 23S ribosomal RNA methyltransferase relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000066 ! clindamycin relationship: confers_resistance_to_antibiotic ARO:3000583 ! pristinamycin IA synonym: "erm(56)" EXACT CARD_Short_Name [] [Term] id: ARO:3007655 name: nifuroxazide namespace: antibiotic_resistance def: "Nifuroxazide is an oral nitrofuran antibiotic used to treat colitis and diarrhea in humans and non-humans. It has recently been explored to be repurposed for parasitic diseases." [PMID:37409934] is_a: ARO:3004116 ! nitrofuran antibiotic xref: pubchem.compound:5337997 [Term] id: ARO:3007656 name: antibiotic resistant Mycobacterium tuberculosis nitroreductase namespace: antibiotic_resistance def: "Inactivation of the F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents plays a role in antibiotic resistance." [PMID:36409105] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3004115 ! nitroimidazole antibiotic [Term] id: ARO:3007657 name: metal transporters with antibiotic efflux namespace: antibiotic_resistance def: "Efflux pumps also regulate the level of metal ions in the cytoplasm but are toxic when in excess. Metals often act as a facilitator in the proliferation and persistence of antibiotic resistance. Therefore, metal contamination in natural environments could have an important role in maintaining and promoting antibiotic resistance. The presence of metals co-selects for antibiotic resistance and leads to the development of cross-resistance. Micro-organisms adopt various mechanisms that may confer resistance against more than one antimicrobial, of which multidrug efflux systems are the most common." [PMID:36282241] is_a: ARO:3000159 ! efflux pump complex or subunit conferring antibiotic resistance [Term] id: ARO:3007658 name: albicidin namespace: antibiotic_resistance def: "Albicidin phytotoxins produced by the sugarcane pathogen Xanthomonas albilineans is a potent DNA gyrase inhibitor with inhibitory effects significantly better than most DNA gyrase inhibitors. Albicidin acts primarily by inhibiting the religation of the cleaved DNA intermediate during the gyrase catalytic sequence similar to quinolones." [PMID:31451755, PMID:17074789] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:78322514 [Term] id: ARO:3007659 name: putative nickel/cobalt transporter namespace: antibiotic_resistance def: "Ectopic expression of NiCoT in Escherichia coli CS109 resulted in the increase of intracellular nickel uptake with enhanced tolerance towards several antibiotics when NiCoT was overexpressed in E. coli and Mycobacterium smegmatis. The presence of a sub-inhibitory dose of nickel resulted in the manifestation of low-level tolerance towards these drugs." [PMID:36282241] is_a: ARO:3007657 ! metal transporters with antibiotic efflux relationship: confers_resistance_to_antibiotic ARO:3000520 ! isoniazid relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid relationship: confers_resistance_to_antibiotic ARO:3000662 ! norfloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin relationship: confers_resistance_to_antibiotic ARO:3000666 ! sparfloxacin relationship: confers_resistance_to_antibiotic ARO:3007382 ! gentamicin synonym: "NiCoT" EXACT [] synonym: "NicT" EXACT [] synonym: "Rv2856" EXACT CARD_Short_Name [] synonym: "Rv2856" EXACT [] [Term] id: ARO:3007660 name: clerocidin namespace: antibiotic_resistance def: "Clerocidin is a terpenoid antibiotic that inhibits bacterial DNA gyrase. It is a natural diterpenoid which has been shown to selectively react with single-stranded bases without targeting the double helix." [PMID:12930966] is_a: ARO:3005172 ! terpene with antibiotic activity xref: pubchem.compound:9896400 [Term] id: ARO:3007661 name: Mycobacterium tuberculosis ddn mutation conferring resistance to nitroimidazole antibiotics namespace: antibiotic_resistance def: "ddn is a protein-coding gene involved in the bioreductive activation of bicyclic 4-nitroimidazole prodrugs such as PA-824 and delamanid developed for anti-tuberculosis therapy against both replicating and persistent bacteria." [PMID:36409105] is_a: ARO:3007656 ! antibiotic resistant Mycobacterium tuberculosis nitroreductase relationship: confers_resistance_to_antibiotic ARO:3004490 ! delamanid relationship: confers_resistance_to_antibiotic ARO:3007535 ! pretomanid synonym: "Mtub_ddn_MULT" EXACT CARD_Short_Name [] [Term] id: ARO:3007662 name: Rv1877 namespace: antibiotic_resistance def: "Rv1877, a putative Major Facilitator Superfamily efflux pump from M. tuberculosis actively effluxes fluoroquinolones ofloxacin and levofloxacin." [PMID:36125560] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000071 ! levofloxacin relationship: confers_resistance_to_antibiotic ARO:3000663 ! ofloxacin synonym: "Rv1877" EXACT CARD_Short_Name [] [Term] id: ARO:3007663 name: stress-activated protein kinases namespace: antibiotic_resistance def: "Stress-activated protein kinases (SAPK) are kinases involved in cellular response to stress whose absence confers resistance to antifungal drug compounds." [PMID:30355673] is_a: ARO:3003768 ! gene conferring resistance via absence relationship: confers_resistance_to_drug_class ARO:3007496 ! echinocandin antibiotic [Term] id: ARO:3007664 name: Candida spp. High Osmolarity Glycerol 1 conferring resistance to caspofungin via absence namespace: antibiotic_resistance def: "Hog1 is a stress-activated protein kinase. Deletion of Hog1 confers resistance to caspofungin through increase in exposed chitin levels in the cell wall." [PMID:30355673] is_a: ARO:3007663 ! stress-activated protein kinases relationship: confers_resistance_to_antibiotic ARO:3007501 ! caspofungin [Term] id: ARO:3007665 name: Candida spp. FCY2 conferring resistance to 5-flucytosine via reduced permeability namespace: antibiotic_resistance def: "FCY2 encodes for purine-cytosine permease in fungal cells. Downregulation or absence of FCY2 confers resistance to antibiotics by preventing entry into the cell." [] is_a: ARO:3007641 ! fungal nucleobase transporters relationship: confers_resistance_to_antibiotic ARO:3007558 ! 5-flucytosine [Term] id: ARO:3007666 name: Candida spp. cyp51A1 with mutations conferring resistance to triazoles and imidazole antibiotics namespace: antibiotic_resistance def: "Candida spp. cyp51A1 is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole and imidazole resistance." [PMID:9527767] is_a: ARO:3007523 ! triazole-resistant fungal cytochrome P450 enzyme is_a: ARO:3007667 ! imidazole-resistant fungal cytochrome P450 enzyme relationship: confers_resistance_to_antibiotic ARO:3007508 ! fluconazole relationship: confers_resistance_to_antibiotic ARO:3007511 ! itraconazole relationship: confers_resistance_to_antibiotic ARO:3007517 ! ketoconazole [Term] id: ARO:3007667 name: imidazole-resistant fungal cytochrome P450 enzyme namespace: antibiotic_resistance def: "Fungal cytochrome P450 enzymes which include mutations to confer resistance to imidazole-class antibiotics." [PMID:9527767] is_a: ARO:3007522 ! antifungal-resistant cytochrome P450 enzyme relationship: confers_resistance_to_drug_class ARO:3007500 ! imidazole antibiotic [Term] id: ARO:3007668 name: HMG-CoA reductase-encoding genes namespace: antibiotic_resistance def: "HMG-CoA reductase-encoding genes which include mutations to confer resistance to antifungal drug compounds." [PMID:30940706] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant relationship: confers_resistance_to_drug_class ARO:3007499 ! triazole antibiotic [Term] id: ARO:3007669 name: aadT namespace: antibiotic_resistance def: "The AadT pump is a novel multidrug efflux pump from the proton antiporter 2 (DHA2) family and was discovered in Acinetobacter multidrug resistance plasmids. The presence of AadT decreased bacterial susceptibility to antibiotics (erythromycin and tetracycline), biocides (chlorhexidine), and dyes (ethidium bromide and DAPI) and was able to mediate ethidium transport." [PMID:37252766] is_a: ARO:0010002 ! major facilitator superfamily (MFS) antibiotic efflux pump relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin relationship: confers_resistance_to_antibiotic ARO:0000051 ! tetracycline relationship: confers_resistance_to_antibiotic ARO:3007039 ! chlorhexidine synonym: "aadT" EXACT CARD_Short_Name [] [Term] id: ARO:3007670 name: Aspergillus spp. Hmg1 with mutations conferring resistance to triazoles antibiotics namespace: antibiotic_resistance def: "Hmg1 is an HMG-CoA reductase-encoding gene with mutations in the gene causing triazole resistance." [PMID:30940706] is_a: ARO:3007668 ! HMG-CoA reductase-encoding genes relationship: confers_resistance_to_antibiotic ARO:3007511 ! itraconazole relationship: confers_resistance_to_antibiotic ARO:3007512 ! voriconazole relationship: confers_resistance_to_antibiotic ARO:3007513 ! posaconazole relationship: confers_resistance_to_antibiotic ARO:3007514 ! isavuconazole [Term] id: ARO:3007671 name: Clostridioides difficile nimB namespace: antibiotic_resistance def: "Clostridioides difficile nimB is a heme-dependent flavin enzyme that degrades nitroimidazoles to amines lacking antimicrobial activity. NimB expression alone is not sufficient for nitroimidazole resistance. Constitutive transcription of nimB, which is driven by a mutation in the promoter PnimBG, is a mechanism of clinically-relevant heme-dependent metronidazole resistance in C. difficile." [PMID:37438331] is_a: ARO:3007103 ! nitroimidazole reductase relationship: confers_resistance_to_antibiotic ARO:3000689 ! metronidazole synonym: "C. difficile nimB" EXACT [] synonym: "CdnimB" EXACT CARD_Short_Name [] [Term] id: ARO:3007672 name: antibiotic resistant Rv0678 namespace: antibiotic_resistance def: "Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump." [PMID:37280265] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3007673 name: bedaquiline resistant Rv0678 namespace: antibiotic_resistance def: "Loss-of-function mutations in rv0678 are a common mechanism of resistance." [PMID:37280265] is_a: ARO:3007672 ! antibiotic resistant Rv0678 relationship: confers_resistance_to_antibiotic ARO:3004492 ! bedaquiline relationship: confers_resistance_to_drug_class ARO:3004491 ! diarylquinoline antibiotic [Term] id: ARO:3007674 name: Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to bedaquiline namespace: antibiotic_resistance def: "Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. Loss-of-function mutations in rv0678 are a common mechanism of resistance." [PMID:37280265] is_a: ARO:3007673 ! bedaquiline resistant Rv0678 relationship: confers_resistance_to_antibiotic ARO:3004492 ! bedaquiline synonym: "Mtub_Rv0678_BDQ" EXACT CARD_Short_Name [] [Term] id: ARO:3007675 name: famotidine namespace: antibiotic_resistance def: "Famotidine enhances the antibacterial activity of rifamycin antibiotics, especially rifampicin, against Gram-negative bacteria and reverses drug resistance. Famotidine disrupts the cell membrane of A. baumannii and inhibits the expression of the outer membrane protein ompA gene, while causing a dissipation of the plasma membrane potential which increases the accumulation of reactive oxygen species leading to increased bacterial mortality. Famotidine also inhibited the efflux pump activity and the biofilm formation of A. baumannii." [PMID:37439688] is_a: ARO:3007224 ! adjuvants inhibiting antibiotic removal is_a: ARO:3007225 ! adjuvants which alter physiology xref: pubchem.compound:5702160 [Term] id: ARO:3007676 name: oxacephem namespace: antibiotic_resistance def: "An oxacephem is a beta-lactam molecule similar to a cephem, but with an oxygen substituted for the sulfur. They show marked enhancement in their antibacterial activity." [PMID:37610203] is_a: ARO:3000007 ! beta-lactam antibiotic [Term] id: ARO:3007677 name: furazidin namespace: antibiotic_resistance def: "Furazidin is a nitrofuran derivative, acting as an antibacterial medicine with bacteriostatic action. It is active against both gram-positive and gram-negative bacteria. It is used for the treatment of urinary tract, skin, and soft tissues infections." [PMID:37629208] is_a: ARO:3004116 ! nitrofuran antibiotic synonym: "furagin" EXACT [] synonym: "furazidine" EXACT [] xref: pubchem.compound:6870646 [Term] id: ARO:3007678 name: IreK namespace: antibiotic_resistance def: "E. faecalis IreK maintains cell wall integrity, possibly by regulating peptidoglycan biosynthesis and metabolism. Antibiotic-induced cell wall stress leads to activation of IreK-mediated phosphorylation signaling pathways to mitigate and repair the damage. Absence of IreK leads to cell envelope defects and increased susceptibility to a variety of cephalosporins, including ceftriaxone. Increased IreK phosphorylation in response to ceftriaxone treatment has been shown to correlate with antimicrobial resistance." [PMID:37517789, PMID:34672600] is_a: ARO:3007683 ! Serine/threonine kinases relationship: confers_resistance_to_antibiotic ARO:0000062 ! ceftriaxone synonym: "IreK" EXACT CARD_Short_Name [] [Term] id: ARO:3007679 name: chrysomycin A namespace: antibiotic_resistance def: "Chrysomycin A (ChryA) is a benzonaphthopyranone glycoside with rapid bactericidal activity that is highly active against S. aureus persisters, robustly eradicates biofilms in vitro, and shows a sustainable killing efficacy in vivo. Chrysomycin A belongs to the coumarin class of antibiotics which are known to bind gyrase subunit B and inhibit the enzyme function." [PMID:37540745] is_a: ARO:3000103 ! aminocoumarin antibiotic synonym: "ChryA" EXACT [] xref: pubchem.compound:73468 [Term] id: ARO:3007680 name: 2,4-diacetylphloroglucinol namespace: antibiotic_resistance def: "2,4-diacetylphloroglucinol (DAPG) is a broad-spectrum antibiotic that was originally isolated from a fluorescent Pseudomonas strain. DAPG is active against numerous organisms, including plants, fungi, viruses, bacteria, and nematodes, and production or increased production of DAPG has been associated with enhanced activity against plant pathogens." [PMID:37653049] is_a: ARO:3005171 ! polyketide with antibiotic activity synonym: "DAPG" EXACT [] xref: pubchem.compound:16547 [Term] id: ARO:3007682 name: MdtQ namespace: antibiotic_resistance def: "MdtQ is a putative multidrug resistance outer membrane protein found in carbapenem resistant Klebsiella pneumoniae." [PMID:37640276] is_a: ARO:3004278 ! Outer Membrane Porin (Opr) synonym: "MdtQ" EXACT CARD_Short_Name [] [Term] id: ARO:3007683 name: Serine/threonine kinases namespace: antibiotic_resistance def: "The eukaryotic-type Ser/Thr kinase (STKs) IreK (intrinsic resistance of enterococci kinase) belongs to a family of transmembrane kinases defined by the presence of multiple extracellular PASTA (penicillin-binding protein and serine/threonine kinase associated) domains. In prokaryotes, STKs modulate cellular functions such as growth, differentiation, and secondary metabolism. When the external environment changes, prokaryotes rely on signal transduction systems, including STKs that quickly sense these changes and alter gene expression to induce the appropriate metabolic changes." [PMID:28698584, PMID:34672600, PMID:22045988] is_a: ARO:3000270 ! protein modulating permeability to antibiotic relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin synonym: "STK" EXACT [] synonym: "ser/thr kineases" EXACT [] [Term] id: ARO:3007684 name: transmembrane protein conferring colistin resistance namespace: antibiotic_resistance def: "Mutations in mgrB transmembrane proteins can confer resistance to the antibiotic colistin." [PMID:25190723] is_a: ARO:3003768 ! gene conferring resistance via absence relationship: confers_resistance_to_drug_class ARO:3000053 ! peptide antibiotic [Term] id: ARO:3007685 name: nifuratel namespace: antibiotic_resistance def: "Nifuratel is a nitrofuran antibiotic already in use for parasitic infections. It was effective against different serovars, including multidrug-resistant strains of Salmonella Typhimurium, and in macrophages from different host species and against Listeria monocytogenes and Shigella flexneri. It reduced IL-10 and STAT3 production in infected macrophages which should increase the inflammatory response against Salmonella." [PMID:37732770] is_a: ARO:3004116 ! nitrofuran antibiotic xref: pubchem.compound:6433427 [Term] id: ARO:3007686 name: mutanobactin namespace: antibiotic_resistance def: "Mutanobactin is produced by a polyketide synthase-nonribosomal peptide synthetase hybrid system encoded by the mub locus. Mutanobactin-producing S. mutans inhibits planktonic and biofilm growth of E. faecalis and is active against other Enterococcus species and Staphylococcus aureus." [PMID:37745448] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:49850903 [Term] id: ARO:3007687 name: zidovudine namespace: antibiotic_resistance def: "Zidovudine is an antibiotic used in the management and treatment of HIV-1. It is in the nucleoside reverse transcriptase inhibitor class of medications." [PMID:37660210] is_a: ARO:3000034 ! nucleoside antibiotic synonym: "azidothymidine" EXACT [] xref: pubchem.compound:35370 [Term] id: ARO:3007688 name: menadione namespace: antibiotic_resistance def: "Menadione exhibits antibacterial activity against methicillin-sensitive and methicillin-resistant S. aureus strains. When combined with oxacillin, it exhibited an additive and synergistic effect against the tested strains. Menadione demonstrated antibiofilm activity and effectively combated biofilms with reduced sensitivity to oxacillin alone. Its mechanism of action involves the production of reactive oxygen species (ROS) and DNA damage. It showed interactions with important targets, such as DNA gyrase and dehydroesqualene synthase." [PMID:37707372] is_a: ARO:3007225 ! adjuvants which alter physiology synonym: "vitamin K3" EXACT [] xref: pubchem.compound:4055 [Term] id: ARO:3007689 name: selamectin namespace: antibiotic_resistance def: "Selamectin is a topical antiparasitic medication for dogs and cats prescribed for various parasite infections. Exposure caused relevant cell surface alterations. A synergistic effect was observed between ampicillin and selamectin. Selamectin may represent a timely and promising macrocyclic lactone for the treatment of S. aureus infections." [PMID:37764086] is_a: ARO:3001318 ! macrocyclic antibiotic xref: pubchem.compound:9578507 [Term] id: ARO:3007690 name: antibiotic resistant Rv2535c namespace: antibiotic_resistance def: "Rv2535c or pepQ encodes a putative Xaa-Pro aminopeptidase and is a new genetic determinant of low-level bedaquiline and clofazimine cross-resistance in Mycobacterium tuberculosis when mutated." [PMID:27185800] is_a: ARO:0000031 ! antibiotic resistant gene variant or mutant [Term] id: ARO:3007691 name: bedaquiline resistant Rv2535c namespace: antibiotic_resistance def: "Loss-of-function mutations in Rv2535c are a common mechanism of resistance." [PMID:27185800] is_a: ARO:3007690 ! antibiotic resistant Rv2535c relationship: confers_resistance_to_drug_class ARO:3004491 ! diarylquinoline antibiotic [Term] id: ARO:3007692 name: Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline namespace: antibiotic_resistance def: "These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine." [PMID:27185800] is_a: ARO:3007691 ! bedaquiline resistant Rv2535c relationship: confers_resistance_to_antibiotic ARO:3004012 ! clofazimine relationship: confers_resistance_to_antibiotic ARO:3004492 ! bedaquiline synonym: "Mtub_Rv2535_BDQ" EXACT CARD_Short_Name [] synonym: "Rv2535c" EXACT [] synonym: "pepQ" EXACT [] [Term] id: ARO:3007693 name: AMZ beta-lactamase namespace: antibiotic_resistance def: "The AMZ genes showed resistance against some beta-lactam antibiotics, including amoxicillin and cephalothin, and the beta-lactamase AMZ-1 exhibited a similar substrate spectrum response. Similar to other AmpC beta-lactamases, AMZ-1 is strongly inhibited by avibactam but much less strongly inhibited by tazobactam." [PMID:37808287] is_a: ARO:3000076 ! class C beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007694 name: AMZ-1 namespace: antibiotic_resistance def: "Achromobacter mucicolens Y3, isolated from a goose on a farm in Wenzhou, showed resistance to multiple antibiotics, including penicillins and cephalosporins. AMZ-1 showed resistance to amoxicillin, penicillin G, ampicillin, cephalothin and cefoxitin, and the resistance activity could be inhibited by beta-lactamase inhibitors." [PMID:37808287] is_a: ARO:3007693 ! AMZ beta-lactamase relationship: confers_resistance_to_antibiotic ARO:0000008 ! cefoxitin relationship: confers_resistance_to_antibiotic ARO:0000064 ! amoxicillin relationship: confers_resistance_to_antibiotic ARO:3000632 ! benzylpenicillin relationship: confers_resistance_to_antibiotic ARO:3000637 ! ampicillin relationship: confers_resistance_to_antibiotic ARO:3000704 ! cefalotin synonym: "AMZ-1" EXACT CARD_Short_Name [] [Term] id: ARO:3007695 name: CMY-185 namespace: antibiotic_resistance def: "We identified ceftazidime/avibactam resistance in E. coli associated with a novel CMY variant. Unlike other AmpC enzymes, CMY-185 appears to require an additional substitution on top of N346Y to confer ceftazidime/avibactam resistance." [PMID:37574665] is_a: ARO:3000069 ! CMY beta-lactamase synonym: "CMY-185" EXACT CARD_Short_Name [] [Term] id: ARO:3007736 name: dexrazoxane namespace: antibiotic_resistance def: "Dexrazoxane is a medication used in the management and treatment of anthracycline-induced cardiotoxicity and extravasation injuries. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Dexrazoxane is a metal ion chelating agent." [PMID:37539785] is_a: ARO:3007222 ! inhibitor of antibiotic resistance mechanism xref: pubchem.compound:71384 [Term] id: ARO:3007696 name: OXA-1-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007697 name: OXA-10-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007698 name: OXA-114-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007699 name: OXA-12-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-12." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007700 name: OXA-134-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007701 name: OXA-143-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007702 name: OXA-184-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007703 name: OXA-198-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-198." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007704 name: OXA-2-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007705 name: OXA-211-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007706 name: OXA-213-like beta-lactamase namespace: antibiotic_resistance def: "OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect." [PMID:24696435] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007707 name: OXA-214-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007708 name: OXA-22-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000032 ! cephalosporin relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007709 name: OXA-229-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007710 name: OXA-23-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007711 name: OXA-24-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007712 name: OXA-266-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-266." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007713 name: OXA-274-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-274." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007714 name: OXA-286-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007715 name: OXA-294-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-294." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007716 name: OXA-364-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-364." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007717 name: OXA-372-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-372." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007718 name: OXA-42-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-42." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007719 name: OXA-427-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-427." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007720 name: OXA-46-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-46." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007721 name: OXA-48-like beta-lactamase namespace: antibiotic_resistance def: "OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins." [PMID:33753332] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007722 name: OXA-493-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-493." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007723 name: OXA-5-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-5." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007724 name: OXA-50-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007725 name: OXA-51-like beta-lactamase namespace: antibiotic_resistance def: "The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance." [PMID:24696435, PMID:17724156] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007726 name: OXA-548-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-548." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007727 name: OXA-55-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapanem-hydrolyzing class D OXA beta-lactamases derived from OXA-55." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007728 name: OXA-58-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007729 name: OXA-60-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007730 name: OXA-61-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007731 name: OXA-62-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007732 name: OXA-63-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007733 name: OXA-679-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-679." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:0000020 ! carbapenem relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007734 name: OXA-727-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-727." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007735 name: OXA-9-like beta-lactamase namespace: antibiotic_resistance def: "A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-9." [] is_a: ARO:3000017 ! OXA beta-lactamase relationship: confers_resistance_to_drug_class ARO:3000008 ! penam [Term] id: ARO:3007745 name: nordihydroguaiaretic acid namespace: antibiotic_resistance def: "Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata that has been used in traditional medicine for the treatment of diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. The inhibition of NDM-1 by nordihydroguaiaretic acid involves its direct binding to the active region of NDM-1." [PMID:37539785] is_a: ARO:3007133 ! polypyridine metallo-beta-lactamase inhibitor xref: pubchem.compound:4534 [Term] id: ARO:3007746 name: embelin namespace: antibiotic_resistance def: "Embelin is a naturally occurring para-benzoquinone isolated from dried berries of Embelia ribes plants. Embelin has a wide spectrum of biological activities, including antioxidant, antitumor, anti-inflammatory, analgesic, anthelmintic, antifertility and antimicrobial. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Embelin is a metal ion chelating agent." [PMID:37539785] is_a: ARO:3007222 ! inhibitor of antibiotic resistance mechanism xref: pubchem.compound:3218 [Term] id: ARO:3007747 name: candesartan cilexetil namespace: antibiotic_resistance def: "Candesartan is an anti-hypertensive drug that was found to have antibacterial activity against MDR S. aureus. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Candesartan is a metal ion chelating agent." [PMID:37539785] is_a: ARO:3007222 ! inhibitor of antibiotic resistance mechanism xref: pubchem.compound:2540 [Term] id: ARO:3007748 name: oncocin namespace: antibiotic_resistance def: "The small proline-rich antimicrobial peptide, oncocin, selectively targets Gram-negative bacteria through special transporters such as SmbA to enter cytoplasm. It presents low toxicity to mammalian cells, because they cannot effectively penetrate the mammalian cellular membrane or they are internalized through an endocytotic process to minimize interaction with cytosolic ribosomes." [PMID:29256010, PMID:37797458] is_a: ARO:3000053 ! peptide antibiotic xref: pubchem.compound:46889826 [Term] id: ARO:3007749 name: Salmonella gallinarum folP with mutation conferring resistance to sulfonamides namespace: antibiotic_resistance def: "Point mutations in Salmonella gallinarum dihydropteroate synthase folP altered the stability of the protein, thus conferring sulfonamide resistance." [PMID:37906281] is_a: ARO:3003415 ! sulfonamide resistant dihydropteroate synthase folP relationship: confers_resistance_to_antibiotic ARO:3000329 ! sulfamethoxazole synonym: "Sgal_folP_SLF" EXACT CARD_Short_Name [] [Term] id: ARO:3007750 name: betaxolol namespace: antibiotic_resistance def: "Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and angina, with a 50% inhibitory concentration (IC50) of 19.3 plus or minus 0.9 uM significantly inhibiting the hydrolytic activity of the NDM-1 enzyme and may represent a potential NDM-1 enzyme inhibitor. BET combined with meropenem (MEM) showed bactericidal synergism in vitro. BET inhibited NDM-1 by competitively binding to it and that it can be developed in combination with MEM as a new therapy." [PMID:37686201] is_a: ARO:3007136 ! unclassified metallo-beta-lactamase inhibitor xref: pubchem.compound:2369 [Term] id: ARO:3007751 name: Salmonella isangi gyrA conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutations in Salmonella gyrA that confer resistance to ciprofloxacin and nalidixic acid which are fluoroquinolone antibiotics." [PMID:37627729] is_a: ARO:3003292 ! fluoroquinolone resistant gyrA relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid synonym: "Sisa_gyrA_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3007752 name: Salmonella isangi gyrB conferring resistance to fluoroquinolones namespace: antibiotic_resistance def: "Point mutation in Salmonella isangi resulting in fluoroquinolone resistance." [PMID:37627729] is_a: ARO:3000864 ! fluoroquinolone resistant gyrB relationship: confers_resistance_to_antibiotic ARO:0000036 ! ciprofloxacin relationship: confers_resistance_to_antibiotic ARO:3000661 ! nalidixic acid synonym: "Sisa_gyrB_FLO" EXACT CARD_Short_Name [] [Term] id: ARO:3007754 name: Lasalocid A namespace: antibiotic_resistance def: "Lasalocid is an antibacterial agent and a coccidiostat, which is produced by strains of Streptomyces lasaliensis. Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase." [PMID:38069118] is_a: ARO:3005171 ! polyketide with antibiotic activity synonym: "Lasalocid" EXACT [] synonym: "Lasalocide" EXACT [] xref: pubchem.compound:5360807 [Term] id: ARO:3007755 name: Calcimycin namespace: antibiotic_resistance def: "Calcimycin (A23187) is a polyether antibiotic and divalent cation ionophore, extracted from Streptomyces chartrecensis." [PMID:38103757] is_a: ARO:3005163 ! ionophore with antibiotic activity synonym: "A23187" EXACT [] xref: pubchem.compound:11957499 [Term] id: ARO:3007756 name: ophiobolin A namespace: antibiotic_resistance def: "Ophiobolin A is a sesterterpene which was initially isolated as fungal phytotoxins and subsequently shown to possess other biological activities, including anticancer activities." [PMID:38131643] is_a: ARO:3005172 ! terpene with antibiotic activity xref: pubchem.compound:5281387 [Term] id: ARO:3007757 name: sphaeropsidin A namespace: antibiotic_resistance def: "Sphaeropsidin A is a tetracyclic pimarane diterpene, first isolated as the main phytotoxin produced by Diplodia cupressir, the causal agent of a severe canker disease of Italian cypress, Cupressus sempervirens L." [PMID:38131643] is_a: ARO:3005172 ! terpene with antibiotic activity xref: pubchem.compound:51361447 [Term] id: ARO:3007758 name: fengycin namespace: antibiotic_resistance def: "Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi and is used as an agricultural fungicide." [PMID:38092837, PMID:29376372] is_a: ARO:3000035 ! lipopeptide antibiotic xref: pubchem.compound:443591 [Term] id: ARO:3007759 name: Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin namespace: antibiotic_resistance def: "Point mutations in 23S rRNA of Treponema pallidum subsp. pallidum (T. pallidum), the noncultivable agent of syphilis, shown clinically to confer resistance to erythromycin, a macrolide antibiotic." [PMID:19429763, PMID:15247355, PMID:10755994] is_a: ARO:3004125 ! 23S rRNA with mutation conferring resistance to macrolide antibiotics relationship: confers_resistance_to_antibiotic ARO:0000006 ! erythromycin synonym: "Tpal_23S_ERY" EXACT CARD_Short_Name [] [Typedef] id: part_of name: part_of xref: RO:part_of [Typedef] id: targeted_by_antibiotic name: targeted_by_antibiotic xref: RO:targeted_by_antibiotic [Typedef] id: is_small_molecule_inhibitor name: is_small_molecule_inhibitor xref: RO:0012006 [Typedef] id: participates_in name: participates_in xref: RO:participates_in [Typedef] id: has_part name: has_part xref: RO:has_part [Typedef] id: confers_resistance_to_drug_class name: confers_resistance_to_drug_class xref: RO:confers_resistance_to_drug_class [Typedef] id: derives_from name: derives_from xref: RO:derives_from [Typedef] id: confers_resistance_to_antibiotic name: confers_resistance_to_antibiotic xref: RO:confers_resistance_to_antibiotic [Typedef] id: evolutionary_variant_of name: evolutionary_variant_of xref: RO:0002312 [Typedef] id: targeted_by name: targeted_by xref: RO:targeted_by [Typedef] id: regulates name: regulates xref: RO:regulates