Alexander Diehl Ceri van Slyke Chris Mungall David Osumi-Sutherland Jim Balhoff Melissa Haendel Nicole Vasilevsky Terry Meehan Yvonne Bradford definition imported from expand expression to expand assertion to term replaced by UBPROP:0000007 uberon true has_relational_adjective Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. has_relational_adjective preferred term when talking about an instance of this class in Homo sapiens latin term plural term abstract upper-level terms not directly useful for analysis subset_property synonym_type_property consider has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_namespace has_related_synonym has_synonym_type in_subset shorthand has_completed A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617). has_high_plasma_membrane_amount A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617). PMID:19243617 A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617). has_low_plasma_membrane_amount A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617). PMID:19243617 has_not_completed http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y lacks_part http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y) lacks_plasma_membrane_part http://semanticscience.org/resource/SIO_000658 direct_transformation_of immediately transforms from immediate_transformation_of immediate_transformation_of direct_transformation_of https://orcid.org/0000-0002-6601-2165 immediately transforms from SIO:000658 A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. CALOHA:TS-2035 FMA:68646 GO:0005623 KUPO:0000002 VHOG:0001533 WBbt:0004017 XAO:0003012 cell The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). cell A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. CARO:mah A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged. BTO:0002290 primary cell culture cell unpassaged cultured cell cell primary cell line cell Covers cells actively being cultured or stored in a quiescent state for future use. primary cultured cell A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged. ReO:mhb OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line. continuous cell line cell permanent cell line cell cell Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts. Covers cells actively being cultured or stored in a quiescent state for future use. obsolete immortal cell line cell true OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line. ReO:mhb A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment). CARO:0000013 cell in vivo cell To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12). native cell A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment). CARO:mah OBSOLETE: A classification of cells by the organisms within which they are contained. CL:0000000 CL:0000003 CL:0001034 cell This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. obsolete cell by organism true OBSOLETE: A classification of cells by the organisms within which they are contained. FB:ma cell fibroblast neural crest derived neuronal receptor cell (sensu Animalia) cell neuronal receptor cell A cell found in the embryo before the formation of all the gem layers is complete. cell early embryonic cell A cell found in the embryo before the formation of all the gem layers is complete. GOC:tfm cell migratory cranial neural crest cell Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues. CL:0000274 cell xylem initial xylem mother cell replaced_by: PO:0000079 obsolete fusiform initial true Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues. ISBN:0471245208 A cell in vitro that is or has been maintained or propagated as part of a cell culture. cell Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture. cultured cell A cell in vitro that is or has been maintained or propagated as part of a cell culture. ReO:mhb cell migratory trunk neural crest cell CL:0000000 CL:0000003 CL:0001034 cell This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. obsolete cell by class true CL:0000140 cell obsolete dentine secreting cell true germline stem cell cell germ line stem cell true true FMA:72290 MA:0002765 VHOG:0001531 ncithesaurus:Spermatogenic_Cell cell male germ cell true cell male germ line stem cell A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids. BTO:0001275 CALOHA:TS-0951 EMAPA:31484 FBbt:00004936 FMA:84049 WBbt:0006799 cell spermatocyte true A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids. GOC:tfm MESH:A05.360.490.890.880 A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa. BTO:0001274 CALOHA:TS-0950 EMAPA:31486 FBbt:00004942 FMA:72294 WBbt:0006800 nematoblast cell spermatid true A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa. MESH:A05.360.490.890.860 A mature male germ cell that develops from a spermatid. BTO:0001277 BTO:0002046 CALOHA:TS-0949 FBbt:00004954 FMA:67338 WBbt:0006798 sperm cell spermatozoid spermatozoon cell sperm true A mature male germ cell that develops from a spermatid. GOC:tfm MESH:A05.360.490.890 An euploid male germ cell of an early stage of spermatogenesis. BTO:0000958 CALOHA:TS-2193 EMAPA:31482 FBbt:00004935 FMA:72291 cell spermatogonium An euploid male germ cell of an early stage of spermatogenesis. MESH:A05.360.490.890.900 Female germ cell is a germ cell that supports female gamete production. MA:0000388 VHOG:0001530 ncithesaurus:Egg cell female germ cell true Female germ cell is a germ cell that supports female gamete production. GOC:tfm PMID:11023867 PMID:20454446 cell female germ line stem cell true true A female germ cell that has entered meiosis. BTO:0000964 CALOHA:TS-0711 FBbt:00004886 FMA:18644 WBbt:0006797 cell oogonium oocyte true A female germ cell that has entered meiosis. GOC:tfm ISBN:0721662544 An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. FMA:83673 cell oogonial cell true An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. GOC:tfm ISBN:0721662544 A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. BTO:0000369 BTO:0003801 CALOHA:TS-2191 FBbt:00057012 FMA:67343 MA:0000388 mature oocyte ovum cell egg cell A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. GOC:tfm ISBN:0721662544 true A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte. BTO:0000953 FBbt:00004878 cell nurse cell invertebrate nurse cell A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte. GOC:tfm PMID:15848391 cell smooth muscle cell neural crest derived true cell CNS neuron (sensu Nematoda and Protostomia) cell neuron neural crest derived true FBbt:00005145 cell glioblast A cell that will develop into a neuron often after a migration phase. BTO:0000930 FBbt:00005146 FMA:70563 cell neuroblast A cell that will develop into a neuron often after a migration phase. GOC:NV http://en.wikipedia.org/wiki/Neuroblast A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops. neural placode cell cell neuroplacodal cell A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops. GOC:tfm ISBN:0618947256 An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance. cell apocrine cell An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance. GOC:tfm ISBN:0721662544 A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. CALOHA:TS-2086 FMA:63368 cell stem cell A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. GOC:tfm MESH:A11.872 A stem cell that self-renews as well as give rise to a single mature cell type. FMA:70569 unipotent stem cell unipotential stem cell cell single fate stem cell A stem cell that self-renews as well as give rise to a single mature cell type. GOC:tfm cell epithelial fate stem cell A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. BTO:0000725 CALOHA:TS-0448 FMA:70337 FMA:86475 VHOG:0001485 HSC blood forming stem cell hemopoietic stem cell cell colony forming unit hematopoietic Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. hematopoietic stem cell A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. GOC:add GOC:dsd GOC:tfm PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell A progenitor cell committed to the erythroid lineage. BTO:0004911 cell BFU-E CFU-E blast forming unit erythroid burst forming unit erythroid colony forming unit erythroid erythroid stem cell erythroid progenitor cell true A progenitor cell committed to the erythroid lineage. GOC:add ISBN:0721601464 A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. cell Originally this term had some plant germ line cell children. germ line cell A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. GOC:tfm ISBN:0721662544 A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus. CALOHA:TS-1195 FMA:83553 cell CFU-M colony forming unit macrophage colony forming unit monocyte monocyte stem cell Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. monoblast true A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus. GOC:add PMID:1104740 http://en.wikipedia.org/wiki/Monoblast http://www.copewithcytokines.de A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive. polymorphonuclear leucocyte polymorphonuclear leukocyte mature eosinocyte mature eosinophil leucocyte mature eosinophil leukocyte cell Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP. mature eosinophil true A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive. GOC:add GOC:dsd GOC:tfm ISBN:0721601464 http://www.cap.org A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor. cell neutrophilic granuloblast These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. neutrophilic myeloblast true A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor. GOC:add ISBN:0721601464 PMID:12560239 PMID:15514007 A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. CL:0000739 polymorphonuclear leucocyte polymorphonuclear leukocyte BTO:0001026 CALOHA:TS-0688 mature basophil leucocyte mature basophil leukocyte cell Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4. mature basophil true A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. GOC:add GOC:dsd GOC:tfm ISBN:0721601464 PMID:18466030 PMID:19231594 PMID:20837449 http://www.cap.org OBSOLETE (was not defined before being made obsolete). cell Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead. obsolete thymus processed stem cell true OBSOLETE (was not defined before being made obsolete). cell Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead. obsolete bursa processed stem cell true Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors. BTO:0002881 CALOHA:TS-2360 FMA:86684 NSC neural stem cell cell neuronal stem cell true Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors. GOC:tfm MESH:D058953 PMID:15247488 http://en.wikipedia.org/wiki/Neural_stem_cell A stem cell that can give rise to multiple lineages of cells. FMA:84789 multi-fate stem cell multifate stem cell multipotent cell multipotent stem cell cell multi fate stem cell A stem cell that can give rise to multiple lineages of cells. GOC:add A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. BTO:0004730 CMP common myeloid precursor cell CFU-GEMM CFU-S colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell pluripotent stem cell (bone marrow) This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). common myeloid progenitor true A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. GOC:add ISBN:0878932437 MESH:D023461 CMP ISBN:0878932437 CFU-GEMM ISBN:0878932437 CFU-S ISBN:0878932437 colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte ISBN:0878932437 multipotential myeloid stem cell ISBN:0878932437 myeloid stem cell ISBN:0878932437 pluripotent stem cell (bone marrow) ISBN:0878932437 A progenitor cell committed to the megakaryocyte and erythroid lineages. CFU-EM CFU-MegE MEP Meg/E progenitor colony forming unit erythroid megakaryocyte megakaryocyte/erythrocyte progenitor megakaryocyte/erythroid progenitor cell cell MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. megakaryocyte-erythroid progenitor cell true A progenitor cell committed to the megakaryocyte and erythroid lineages. GOC:add GOC:dsd GOC:tfm MESH:D055015 PMID:16647566 http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell A oligopotent progenitor cell committed to the lymphoid lineage. CL:0000044 CLP common lymphocyte precursor common lymphocyte progenitor common lymphoid precursor cell ELP committed lymphopoietic stem cell early lymphocyte progenitor lymphoid stem cell lymphopoietic stem cell CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. common lymphoid progenitor true A oligopotent progenitor cell committed to the lymphoid lineage. GOC:add GOC:dsd GOC:tfm PMID:10407577 PMID:16551251 A stem cell from which all cells of the body can form. FMA:84790 totipotential stem cell cell totipotent stem cell A stem cell from which all cells of the body can form. GOC:add GOC:tfm cell bone matrix secreting cell A precursor cell with a limited number of potential fates. BTO:0000125 FMA:84782 blast cell cell define using PATO mulit-potent or oligopotent? non-terminally differentiated cell A precursor cell with a limited number of potential fates. SANBI:mhl A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. BTO:0000222 CALOHA:TS-0650 FBbt:00005083 FMA:70335 VHOG:0001529 cell myoblast A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. GOC:tfm MESH:A11.635 PMID:21849021 A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. BTO:0000452 CALOHA:TS-0362 FMA:63877 VHOG:0001482 cell These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. fibroblast A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. ISBN:0517223651 MESH:A11.329.228 MESH:D005347 http://en.wikipedia.org/wiki/Fibroblast Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. BTO:0003607 FMA:66783 chrondoplast cell chondroblast Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. GOC:tfm GO_REF:0000034 ISBN:0618947256 Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell. CL:0000053 CL:0000139 BTO:0001663 FMA:70576 amelocyte enamel secreting cell cell non-encoded relationship from VSAO produces VSAO:0000066 ameloblast Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell. GOC:tfm GO_REF:0000034 MESH:A11.436.107 Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell. BTO:0001769 CALOHA:TS-0696 FMA:62999 cell legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin. odontoblast Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell. GO_REF:0000034 ISBN:0618947256 Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell. CL:0000859 CALOHA:TS-1164 FMA:63002 cementum secreting cell cell Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth. cementoblast Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell. GO_REF:0000034 ISBN:0781733901 Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell. BTO:0001593 CALOHA:TS-0720 FMA:66780 cell non-encoded relationships from VSAO - capable_of_producing VSAO:0000020 osteoblast Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell. GO_REF:0000034 MESH:A11.329.629 OBSOLETE: A classification of cells by their microscopic appearance. CL:0000000 CL:0000003 CL:0001034 cell This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. obsolete cell by histology true OBSOLETE: A classification of cells by their microscopic appearance. FB:ma GOC:tfm A cell that has a filiform extrusion of the cell surface. VHOG:0001532 XAO:0000031 cell ciliated cell A cell that has a filiform extrusion of the cell surface. GOC:tfm A neurectoderm derived cell that lines the neural lumen. BTO:0001724 FMA:70550 ependymocyte cell ependymal cell A neurectoderm derived cell that lines the neural lumen. GOC:tfm JB:jb PMID:9550134 A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. BTO:0000414 CALOHA:TS-2026 CARO:0000077 FBbt:00000124 FMA:66768 WBbt:0003672 epitheliocyte cell epithelial cell A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. FB:ma GOC:tfm MESH:A11.436 An epithelial cell that has a cillia. FMA:70605 cell ciliated epithelial cell An epithelial cell that has a cillia. GOC:tfm cell duct epithelial cell cell branched duct epithelial cell cell obsolete epithelial cell of gland true An endothelial cell that lines the vasculature. cuboidal endothelial cell of vascular tree cell blood vessel endothelial cell true An endothelial cell that lines the vasculature. GOC:tfm cell non-branched duct epithelial cell cell barrier epithelial cell Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap. cell replaced_by: PO:0000066 obsolete epithem cell true Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap. ISBN:0471245208 PMID:12662305 cell columnar/cuboidal epithelial cell CALOHA:TS-1249 cell squamous epithelial cell A flattened epithelial cell of mesenchymal origin that lines the serous cavity. FMA:66773 mesotheliocyte cell mesothelial cell A flattened epithelial cell of mesenchymal origin that lines the serous cavity. GOC:tfm ISBN:0721662544 cell peridermal cell cell stratified epithelial cell A cell which moves among different tissues of the body, via blood, lymph, or other medium. cell circulating cell A cell which moves among different tissues of the body, via blood, lymph, or other medium. GOC:add A cell found predominately in the blood. FMA:62844 cell blood cell true A cell found predominately in the blood. GOC:add GOC:tfm BTO:0004299 lung epithelial cell cell epithelial cell of lung An epithelial cell of the pancreas. BTO:0000028 pancreas epithelial cell pancreatic epithelial cell cell epithelial cell of pancreas true An epithelial cell of the pancreas. GOC:tfm A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. CL:0000804 CL:0000812 BTO:0000782 CALOHA:TS-1001 FMA:62870 VHOG:0001479 T lymphocyte T-cell T-lymphocyte cell immature T cell mature T cell T cell true A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. GOC:add GOC:tfm ISBN:0781735149 cell germ line stem cell (sensu Vertebrata) FBbt:00004861 cell germ line stem cell (sensu Nematoda and Protostomia) FBbt:00004929 cell male germ line stem cell (sensu Nematoda and Protostomia) FBbt:00004873 cell female germ line stem cell (sensu Nematoda and Protostomia) spermatogonial stem cell cell male germ line stem cell (sensu Vertebrata) spermatogonial stem cell PMID:19948499 cell female germ line stem cell (sensu Vertebrata) A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. BTO:0000685 FMA:14656 hepatic macrophage littoral cell of hepatic sinusoid liver macrophage macrophagocytus stellatus stellate cell of von Kupffer von Kupffer cell cell Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. Kupffer cell true A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. GOC:add GOC:tfm GO_REF:0000031 ISBN:0517223651 MESH:A11.329.372.588 PMID:15771589 PMID:17105582 A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. BTO:0000968 CALOHA:TS-0721 FMA:66781 cell chondroclast Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. osteoclast true true A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 PMID:10428500 PMID:15055519 PMID:17380158 OBSOLETE (was not defined before being made obsolete). cell Consider using 'osteoclast ; CL:0000092' instead. obsolete osteochondroclast true A leukocyte with abundant granules in the cytoplasm. BTO:0000539 BTO:0001026 CALOHA:TS-0422 FMA:62854 granular leucocyte granular leukocyte polymorphonuclear leukocyte cell granulocyte true A leukocyte with abundant granules in the cytoplasm. GOC:amm GOC:tfm MESH:A11.118.637.415 MESH:D006098 http://en.wikipedia.org/wiki/Granulocyte cell neuron associated cell A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive. poly polymorphonuclear leucocyte polymorphonuclear leukocyte BTO:0003473 PMN mature neutrocyte mature neutrophil leucocyte mature neutrophil leukocyte mature neutrophilic leucocyte mature neutrophilic leukocyte polymorphonuclear neutrophil polynuclear neutrophilic leucocyte polynuclear neutrophilic leukocyte cell Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). mature neutrophil true A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive. GOC:add GOC:tfm MESH:A11.118.637.415.583 MESH:D009504 PMID:11138776 PMID:12560239 PMID:15514007 PMID:7880385 http://www.cap.org A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. BTO:0000830 CALOHA:TS-0603 FMA:66784 histaminocyte labrocyte mastocyte cell tissue basophil Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. mast cell true A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. GOC:add GOC:dsd GOC:tfm ISBN:068340007X MESH:A11.329.427 MESH:D008407 PMCID:PMC1312421 PMCID:PMC2855166 PMID:15153310 PMID:16455980 PMID:19671378 PMID:212366338 PMID:9354811 labrocyte ISBN:0721601464 mastocyte ISBN:0721601464 tissue basophil ISBN:068340007X A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. neuroepithelial cell BTO:0004301 cell The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). sensory epithelial cell A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. GOC:tfm ISBN:0517223651 ISBN:0721662544 Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. BTO:0003811 FBbt:00005125 FMA:67313 WBbt:0005113 cell interneuron Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. GOC:tfm MESH:A08.663.358 An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. BTO:0000312 FMA:83617 WBbt:0005409 motoneuron anterior horn cell cell motor neuron An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. MESH:A08.663.655.500 PMID:16875686 Any neuron having a sensory function; an afferent neuron conveying sensory impulses. BTO:0001037 FBbt:00005124 FMA:84649 WBbt:0005759 cell sensory neuron Any neuron having a sensory function; an afferent neuron conveying sensory impulses. ISBN:0721662544 cell polymodal neuron A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body. FMA:67282 cell bipolar neuron A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body. GOC:tfm ISBN:0444009442 Neuron with an axon and two or more dendrites. FMA:67287 cell multipolar neuron Neuron with an axon and two or more dendrites. FMA:67287 GOC:tfm Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma. FMA:67305 cell pseudounipolar neuron Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma. FMA:67305 GOC:tfm Neuron with one neurite that extends from the cell body. FMA:67278 cell unipolar neuron Neuron with one neurite that extends from the cell body. FMA:67278 GOC:nv A neruon whose cell body is within an autonomic ganglion. FMA:80121 cell autonomic neuron A neruon whose cell body is within an autonomic ganglion. GOC:tfm A neuron that uses acetylcholine as a vesicular neurotransmitter. BTO:0004902 FMA:84796 WBbt:0006840 cell cholinergic neuron A neuron that uses acetylcholine as a vesicular neurotransmitter. GOC:tfm cell adrenergic neuron cell peptidergic neuron A neuron that is part of nerve found outside the central nervous system. FMA:84664 cell peripheral neuron A neuron that is part of nerve found outside the central nervous system. ISBN:0721662544 cell columnar neuron columnar neuron A vertebrate phagocyte with a single nucleus. BTO:0001433 cell mononuclear phagocyte true A vertebrate phagocyte with a single nucleus. GOC:add GOC:tfm ISBN:0781735149 FMA:72552 cell of surface ectoderm surface ectoderm cell cell surface ectodermal cell An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. BTO:0001176 CALOHA:TS-0278 FMA:66772 endotheliocyte cell From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. endothelial cell An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. GOC:tfm MESH:D042783 PMID:21275341 http://en.wikipedia.org/wiki/Endothelial_cell https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855 Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance. FBbt:00005128 cell pioneer neuron Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance. GOC:cvs GOC:tfm cell CNS neuron (sensu Vertebrata) cell basket cell Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004. Golgi cell Golgi neuron cerebellar Golgi neuron cerebellum Golgi cell cell cerebellar Golgi cell Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004. NIFSTD:sao1415726815 BTO:0003393 cell granule cell The output neuron of the cerebellar cortex. BTO:0001011 CALOHA:TS-0845 FMA:67969 Purkinje neuron Purkinje's cell cerebellar Purkinje cell cerebellum Purkinje cell cell Purkinje cell The output neuron of the cerebellar cortex. MESH:A08.186.211.132.810.428.200.212.600 BTO:0002316 cell stellate neuron cell neuron associated cell (sensu Vertebrata) FBbt:00005144 cell glial cell (sensu Nematoda and Protostomia) A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. BTO:0002606 CALOHA:TS-0415 FMA:54536 neuroglial cell cell neuroglia glial cell It is unclear that all glial cells develop from a cell type called a glioblast. Radial glial cells develop from neuroepithelial cells and other types of glial cells develop from other precursors. Unless glioblast is meant to describe any cell that can give rise to a glial cell, this relationship needs further investigation. A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. MESH:A08.637 A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together. BTO:0000771 CALOHA:TS-2027 FMA:54538 macrogliocyte cell macroglial cell A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together. GOC:tfm ISBN:0721662544 A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury. BTO:0000099 CALOHA:TS-0060 FMA:54537 astrocytic glia cell Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. astrocyte A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury. GOC:dsd GOC:tfm MESH:A08.637.200 MESH:D001253 PMID:11746784 PMID:12162730 PMID:12898703 PMID:20942978 http://en.wikipedia.org/wiki/Astrocyte A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system. BTO:0000962 CALOHA:TS-0709 FMA:54540 OLs cell oligodendroglia Oligodendrocytes are reportedly MDP-positive and CD4-negative. oligodendrocyte true A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system. MESH:A08.637.600 MESH:D009836 http://en.wikipedia.org/wiki/Oligodendrocyte OLs PMID:8734446 A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. brain macrophage BTO:0000078 BTO:0000962 FMA:54539 FMA:54540 brain-resident macrophage hortega cells microglia microgliocyte cell MF.microglia.CNS Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. microglial cell true A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. GOC:add GOC:dsd GOC:tfm ISBN:0721601464 MESH:D017628 PMID:11517395 PMID:12430718 PMID:14561199 PMID:14612429 PMID:16177057 PMID:19461673 PMID:2089275 http://en.wikipedia.org/wiki/Microglia hortega cells http://www.copewithcytokines.de/ microgliocyte http://www.copewithcytokines.de/ cell neuron associated cell (sensu Nematoda and Protostomia) cell gut endothelial cell Cell of the single layer of large flattened cells covering the surface of the cornea. CALOHA:TS-0172 FMA:70614 cell corneal endothelial cell Cell of the single layer of large flattened cells covering the surface of the cornea. GOC:tfm MESH:A09.371.060.067.31 Ectoderm destined to be nervous tissue. neurectoderm cell cell neurectodermal cell Ectoderm destined to be nervous tissue. GOC:tfm ISBN:068340007X A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. CL:0002452 BTO:0002625 BTO:0003298 FMA:70546 BMSC bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells cell CFU-F MSC mesenchymal precursor cell mesenchymal progenitor cells mesenchymal stem cell mesenchymal stromal cell mesenchymal stromal cells stem cells, mesenchymal Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. mesenchymal stem cell true A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. FB:ma GOC:dsd PMCID:PMC2613570 PMID:10102814j PMID:16923606 PMID:17986482 PMID:19960544 http://en.wikipedia.org/wiki/Mesenchymal_stem_cell http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells marrow stromal cells PMID:11378515 MSC PMID:11378515 mesenchymal progenitor cells MESH:D044982 mesenchymal stromal cells stem cells, mesenchymal MESH:D044982 An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes. FMA:63879 cell Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A. fibrocyte true An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes. GOC:dsd GOC:tfm ISBN:0412046911 ISBN:0517223651 PMID:11641248 PMID:15010326 PMID:17607298 PMID:18222966 PMID:8790603 PMID:9551999 http://en.wikipedia.org/wiki/Fibrocyte A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. CL:0000450 BTO:0000443 CALOHA:TS-0012 FMA:63880 adipocyte adipose cell cell fat cell A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. MESH:A11.329.114 A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi. bone cell BTO:0002038 CALOHA:TS-1167 FMA:66779 VSAO:0000124 cell VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 osteocyte A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi. GOC:tfm MESH:A11.329.629.500 Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. BTO:0000249 CALOHA:TS-0138 FMA:66782 cartilage cell cell chondrocyte Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. GO_REF:0000034 MESH:A11.329.171 Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell. cell odontocyte Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell. GO_REF:0000034 An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth. FMA:63003 cell CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def). cementocyte An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth. ISBN:0781733901 A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen. BTO:0004271 FMA:70620 cell vitreous cell hyalocyte A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen. GOC:tfm PMID:19073178 cell guidepost cell OBSOLETE: A classification of cells by their primary end goal or behavior. CL:0000000 CL:0000003 CL:0001034 cell This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. obsolete cell by function true OBSOLETE: A classification of cells by their primary end goal or behavior. FB:ma A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. APC cell Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. GOC:add ISBN:0781735149 cell simple columnar epithelial cell A pigment cell is a cell that contains pigment granules. VHOG:0001678 chromatocyte chromatophore cell pigment cell A pigment cell is a cell that contains pigment granules. GOC:tfm A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance. CL:0000572 BTO:0000847 CALOHA:TS-0613 FMA:70545 VHOG:0001679 melanophore cell melanocyte true A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance. SANBI:mhl pigment cell cell visual pigment cell A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. CALOHA:TS-2085 FMA:86494 cell glandular epithelial cell A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. GOC:tfm A cell that specializes in controlled release of one or more substances. BTO:0003659 FMA:86916 cell secretory cell A cell that specializes in controlled release of one or more substances. GOC:tfm ISBN:0721662544 A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. FMA:16014 cell exocrine cell A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. ISBN:0198547684 A cell that secretes glycosaminoglycans. GAG secreting cell hyaluronic acid secreting cell cell glycosaminoglycan secreting cell A cell that secretes glycosaminoglycans. GOC:tfm cell protein secreting cell A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen. FMA:62902 chief cell of stomach gastric chief cell pepsinogen secreting cell zymogenic cell cell peptic cell A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen. GOC:tfm OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize. cell Consider using 'B cell ; CL:0000236' or one of its children instead. obsolete antibody secreting cell true A cell that specializes in secretion of surfactant in the alveoli of the lung. cell surfactant secreting cell true A cell that specializes in secretion of surfactant in the alveoli of the lung. GOC:tfm ISBN:0721662544 Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium. BTO:0004811 FMA:14119 Clara cell of bronchiole bronchiolar non-ciliated cell cell Clara cell true Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium. GOC:tfm PMID:12107102 PMID:7905712 cell seromucus secreting cell A cell of the epithelial lining that produce and secrete mucins. BTO:0001540 FMA:13148 http://en.wikipedia.org/wiki/Goblet_cell chalice cell cell goblet cell A cell of the epithelial lining that produce and secrete mucins. MESH:A03.492.411.369.320 cell acid secreting cell true A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl. BTO:0001780 FMA:62901 oxyntic cell cell parietal cell A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl. GOC:tfm ISBN:0517223651 A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. FMA:83809 endocrinocyte cell endocrine cell A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. MESH:A06.407 An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. BTO:0003865 FMA:62930 cell enteroendocrine cell An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. GOC:tfm SANBI:mhl An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals. BTO:0002691 FMA:83810 neurosecretory cell cell neuroendocrine cell An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals. MESH:A06.688 A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system. BTO:0000259 FMA:69263 phaeochromocyte cell chromaffin cell A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system. MESH:A06.224.161 cell peptide hormone secreting cell BTO:0000783 cell insulin secreting cell A cell that secretes insulin and is located towards the center of the islets of Langerhans. beta cell BTO:0000783 EV:0200009 FMA:70586 MA:0002419 ncithesaurus:Beta_Cell B-cell of pancreatic islet beta cell of pancreatic islet insulin-secreting cell pancreatic B cell pancreatic B-cell pancreatic beta cell pancreatic islet core type B enteroendocrine cell cell beta cell islet Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. type B pancreatic cell true true A cell that secretes insulin and is located towards the center of the islets of Langerhans. GOC:tfm ISBN:0517223651 http://en.wikipedia.org/wiki/Pancreatic_b_cell beta cell ZFA:0009102 B-cell of pancreatic islet FMA:70586 beta cell of pancreatic islet FMA:70586 insulin-secreting cell FMA:70586 pancreatic B-cell FMA:70586 pancreatic beta cell FMA:70586 pancreatic islet core MA:0002419 type B enteroendocrine cell FMA:70586 beta cell islet MA:0002419 A cell that secretes glucagon. FMA:84045 glucagon-secreting cell cell glucagon secreting cell A cell that secretes glucagon. GOC:tfm A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. BTO:0000990 FMA:70585 alpha cell of iselt of Langerhans pancreatic alpha cell cell pancreatic A cell A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. GOC:tfm ISBN:0721662544 cell somatostatin secreting cell A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. BTO:0000803 FMA:70587 D-cell of pancreatic islet delta cell of islet delta cell of pancreatic islet pancreatic D-cell pancreatic delta cell somatostatin-secreting pancreatic cell cell pancreatic D cell A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. FMA:0517223651 GOC:tfm cell steroid hormone secreting cell A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells. BTO:0003939 FMA:18688 lutein cell cell luteal cell A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells. MESH:A05.360.319.114.630.278.400 cell ecdysteroid secreting cell cell testosterone secreting cell A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. interstitial cell BTO:0000755 CALOHA:TS-1150 EMAPA:29655 FMA:72297 interstitial cell of Leydig cell Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated Leydig cell A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. GOC:tfm PMID:12050120 cell progesterone secreting cell cell estradiol secreting cell A cell whose primary function is intermediary metabolism. cell metabolising cell A cell whose primary function is intermediary metabolism. FB:ma The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. BTO:0000575 CALOHA:TS-0454 FMA:14515 cell Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. hepatocyte The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. GOC:tfm ISBN:0412046911 MESH:A11.436.348 PMID:19717280 http://en.wikipedia.org/wiki/Hepatocyte A cell whose primary function is to shorten. cell contractile cell A cell whose primary function is to shorten. FB:ma Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament. BTO:0002309 CALOHA:TS-2379 FMA:67799 basket epithelial cell myoepitheliocyte cell myoepithelial cell Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament. GOC:tfm ISBN:0721662544 An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell. MFB cell Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha. myofibroblast cell An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell. GOC:dsd GOC:tfm MESH:D058628 PMID:19800625 PMID:20630469 MFB PMID:8731193 A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. BTO:0000888 BTO:0000902 CALOHA:TS-2032 FBbt:00005074 FMA:67328 WBbt:0003675 muscle fiber myocyte cell muscle cell A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. MESH:A11.620 A somatic cell located in skeletal muscle. BTO:0004392 CALOHA:TS-2158 FMA:9727 skeletal muscle cell cell cell of skeletal muscle A somatic cell located in skeletal muscle. GOC:tfm A muscle cell that develops tension more slowly than a fast-twitch fiber. FMA:84448 cell slow muscle fiber slow muscle cell A muscle cell that develops tension more slowly than a fast-twitch fiber. GOC:tfm ISBN:0323052908 slow muscle fiber ISBN:0815316208 A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron . glycolytic muscle fiber cell fast muscle cell A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron . GOC:tfm ISBN:0323052908 A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). CL:0000191 BTO:0004576 CALOHA:TS-2159 FMA:14072 SMCs myocytes, smooth muscle smooth muscle fiber non-striated muscle cell cell smooth muscle cell A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). MESH:A11.620.520 MESH:D032389 PMID:9315361 http://en.wikipedia.org/wiki/Smooth_muscle_cell SMCs PMID:9315361 myocytes, smooth muscle MESH:D032389 A striated muscle cell of an arthropod heart that participates in heart contraction. CL:0000466 cell cardiac muscle cell (sensu Arthopoda) A striated muscle cell of an arthropod heart that participates in heart contraction. MESH:A11.620.500 cell Consider CL:0002072. obsolete nodal cardiac cell true cell obsolete Purkinje fiber true cell flight muscle cell cell receptor cell The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings. nociceptor nocireceptor cell Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship pain receptor cell The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings. MESH:A08.800.550.700.650 A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. cell mechanoreceptor mechanoreceptor cell A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. MESH:A08.800.550.700.500 mechanoreceptor MP:0000972 cell touch receptor cell A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system. CL:0000201 FMA:62364 auditory receptor cell cochlear hair cell cell inner ear hair cell inner ear receptor cell In mammals these cells are located in the organ of Corti. auditory hair cell A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system. MESH:A08.663.650.250 inner ear hair cell GO:0060119 inner ear receptor cell GO:0060119 cell gravity sensitive cell cell acceleration receptive cell A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain. cell thermoreceptor cell A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain. GOC:tfm MESH:A08.800.550.700.840 MP:0000971 A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. cell chemoreceptor cell A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. MESH:A08.800.550.700.120 BTO:0004185 FMA:67860 Wikipedia:Olfactory_receptor_neuron Schultze's cell odorant receptor cell olfactory receptor neuron olfactory sensory neuron cell olfactory receptor cell cell pH receptor cell A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste. FMA:67910 taste bud cell cell taste receptor cell A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste. GOC:tfm ISBN:0618947256 A cell specialized to detect and transduce light. BTO:0001060 CALOHA:TS-0868 FBbt:00004211 FMA:86740 cell photoreceptor cell true A cell specialized to detect and transduce light. MESH:A08.663.650.650 A cell whose function is determined by the generation or the reception of an electric signal. cell electrically active cell A cell whose function is determined by the generation or the reception of an electric signal. FB:ma A cell that takes up and metabolizes substances. cell absorptive cell A cell that takes up and metabolizes substances. CL:CVS A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. boundary cell cell lining cell A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. JB:jb A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid. BTO:0003652 CALOHA:TS-0995 FMA:66786 synoviocyte hyaluronic acid secreting cell cell synovial cell true A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid. GOC:tfm ISBN:0721662544 PMID:17942474 A cell whose primary function is to prevent the transport of stuff across compartments. cell barrier cell A cell whose primary function is to prevent the transport of stuff across compartments. JB:jb A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier. BTO:0001238 CALOHA:TS-0922 FMA:72298 VHOG:0001348 cell Sertoli cell true A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier. MESH:A05.360.444.849.789 cell insulating cell A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons. Schwann cell peripheral neuroglial cell CALOHA:TS-0898 FMA:62121 neurilemmal cell cell myelinating Schwann cell A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons. GOC:cvs GOC:tfm MESH:A08.637.800 A cell that moves by its own activities. cell motile cell A cell that moves by its own activities. FB:ma CL:0000000 CL:0000003 CL:0001034 cell This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. obsolete cell by lineage true A cell of the outer of the three germ layers of the embryo. FMA:72549 ectoderm cell cell ectodermal cell A cell of the outer of the three germ layers of the embryo. MESH:A16.254.425.273 A cell of the middle germ layer of the embryo. FMA:72554 mesoblast mesoderm cell cell mesodermal cell A cell of the middle germ layer of the embryo. MESH:A16.254.425.660 A cell of the inner of the three germ layers of the embryo. FMA:72555 endoderm cell cell endodermal cell A cell of the inner of the three germ layers of the embryo. MESH:A16.254.425.407 OBSOLETE: A classification of cells by the number of their nuclei. CL:0000000 CL:0000003 CL:0001034 cell This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. obsolete cell by nuclear number true OBSOLETE: A classification of cells by the number of their nuclei. FB:ma GOC:tfm A cell that lacks a nucleus. FMA:68647 non-nucleated cell cell anucleate cell A cell that lacks a nucleus. FB:ma A cell with a single nucleus. cell single nucleate cell A cell with a single nucleus. FB:ma GOC:tfm cell binucleate cell A cell with more than one nucleus. AEO:0000203 WBbt:0008074 syncitium syncytial cell syncytium cell multinucleate cell A cell with more than one nucleus. FB:ma OBSOLETE (was not defined before being made obsolete). cell Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead. obsolete lymphoblast true OBSOLETE (was not defined before being made obsolete). cell Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead. obsolete T lymphoblast true OBSOLETE (was not defined before being made obsolete). cell Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead. obsolete B lymphoblast true A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. BTO:0000424 CALOHA:TS-0290 FMA:81100 RBC red blood cell cell erythrocyte true A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. GOC:tfm MESH:A11.118.290 A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. BTO:0000132 CALOHA:TS-0803 FMA:62851 anucleate thrombocyte blood platelet enucleate thrombocyte cell Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. platelet true A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. GOC:add GOC:dsd GOC:tfm MESH:A11.118.188 MESH:D001792 PMID:11110672 PMID:16987572 PMID:17204662 PMID:17479180 PMID:20414831 http://en.wikipedia.org/wiki/Platelet Any cell capable of ingesting particulate matter via phagocytosis. BTO:0001044 FMA:83806 cell phagocyte Any cell capable of ingesting particulate matter via phagocytosis. GOC:add ISBN:0721601464 A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. BTO:0000801 CALOHA:TS-0587 FMA:63261 FMA:83585 histiocyte cell Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. macrophage true A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. GOC:add GOC:tfm GO_REF:0000031 PMID:16213494 PMID:1919437 A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity. BTO:0000776 CALOHA:TS-0068 FMA:62869 VHOG:0001480 B lymphocyte B-cell B-lymphocyte cell B cell true A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 cell keratinizing barrier epithelial cell cell non keratinizing barrier epithelial cell cell brush border epithelial cell cell stratified squamous epithelial cell cell stratified cuboidal epithelial cell A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. FMA:70548 Merkel's cell cell Merkel cell PMID:19782676 A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. MESH:A08.800.550.700.500.425 A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear. cell glial cell (sensu Vertebrata) A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear. MESH:A08.637 A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium. FMA:66778 cell transitional epithelial cell A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium. GOC:tfm ISBN:0721662544 Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis. cell replaced_by: PO:0000353 obsolete passage cell true Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis. ISBN:0471245208 cell Mauthner neuron Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings. AAO:0010316 EFO:0003711 VHOG:0001484 Rohon Beard cell Rohon-Beard cell cell RB neuron Rohon-Beard neuron Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings. VHOG:0001484 Rohon Beard cell VHOG:0001484 RB neuron VHOG:0001484 Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell. pollen mother cell primary sporogenous cell cell replaced_by: PO:0020047 obsolete microsporocyte true Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell. ISBN:0471245208 cell hatching gland cell Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants. cell replaced_by: PO:0020019 obsolete megaspore true Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants. ISBN:0471245208 cell extramedullary cell Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants. cell replaced_by: PO:0020048 obsolete microspore true Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants. ISBN:0471245208 cell eurydendroid cell Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants. female gametophyte egg cell cell replaced_by: PO:0020094 obsolete egg cell true Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants. TAIR:lr cell eukaryotic cell cell uric acid accumulating cell cell Mycetozoan cell Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures. cell replaced_by: PO:0000355 obsolete fiber tracheid true Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures. ISBN:0471245208 DDANAT:0000403 obsolete aggregate cell true Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water. cell replaced_by: PO:0000373 obsolete mucilage cell true Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water. ISBN:0471245208 cell anterior cell Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells. cell replaced_by: PO:0000351 obsolete guard mother cell true Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells. ISBN:0471245208 DDANAT:0000002 obsolete vegetative cell (sensu Mycetozoa) true Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes. phloem mother cell cell replaced_by: PO:0000400 obsolete phloem initial true Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes. ISBN:0471245208 DDANAT:0000404 obsolete anterior like cell true Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells. cell replaced_by: PO:0004011 obsolete meristemoid true Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells. ISBN:0471245208 DDANAT:0000405 obsolete prespore cell true Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member. cell obsolete sieve element true Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member. ISBN:0471245208 DDANAT:0000406 obsolete prestalk cell true Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue. cell replaced_by: PO:0000284 obsolete subsidiary cell true Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue. ISBN:047124520 DDANAT:0000408 obsolete prestalk A cell true OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells). cell replaced_by PO:0000295 obsolete cambial initial true OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells). ISBN:0471245208 DDANAT:0000410 obsolete prestalk AB cell true DDANAT:0000409 obsolete prestalk B cell true Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity. cell replaced_by: PO:0000077 obsolete sclerenchyma cell true Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity. ISBN:0471245208 OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells. DDANAT:0000406 cell This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology. obsolete prestalk I cell true OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells. DictyBase:DDB Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm. cell replaced_by: PO:0020090 obsolete central cell true Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm. TAIR:lr DDANAT:0000407 obsolete prestalk 0 cell true Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization. cell replaced_by: PO:0020097 obsolete generative cell true Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization. TAIR:lr DDANAT:0000411 obsolete pstAB/ALC true Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata. cell replaced_by: PO:0000282 obsolete trichome true Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata. ISBN:0471245208 PMID:10938806 DDANAT:0000412 obsolete pstO/ALC true Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member. cell replaced_by: PO:0000071 obsolete companion cell true Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member. ISBN:0879015322 DDANAT:0000413 obsolete stalk cell true A cell of a filament of a fungal mycelium. cell hyphal cell A cell of a filament of a fungal mycelium. ISBN:08199377X cell eye photoreceptor cell Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization. cell replaced_by: PO:0000191 obsolete synergid true Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization. ISBN:047125208 DDANAT:0000402 obsolete chemotactic amoeboid cell (sensu Mycetozoa) true Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers. cell replaced_by: PO:0000274 obsolete xylem fiber cell true Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers. ISBN:0471245208 DDANAT:0000414 obsolete spore (sensu Mycetozoa) true Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor. stomatal guard cell cell replaced_by: PO:0000293 obsolete guard cell true Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor. ISBN:0471245208 A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. cell structural cell A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. TAIR:sr Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. cell obsolete sieve cell true Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. ISBN:0471245208 A peptide hormone secreting cell that produces growth hormone, somatotropin. CL:0000471 growth hormone secreting cell somatotrophin secreting cell cell somatotropin secreting cell A peptide hormone secreting cell that produces growth hormone, somatotropin. GOC:tfm SANBI:mhl Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus. cell replaced_by: PO:0020099 obsolete vegetative cell true Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus. ISBN:0140514031 TAIR:lr Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome. cell replaced_by: PO:0000115 obsolete socket cell true Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome. PMID:10938806 Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem. cell replaced_by: PO:0000273 obsolete xylem element true Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem. ISBN:0471245208 OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair. cell Obsoleted. Use trichoblast from the plant ontology (PO:0000262). obsolete trichoblast true OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair. ISBN:0471245208 A mature sexual reproductive cell having a single set of unpaired chromosomes. CALOHA:TS-0395 FBbt:00005412 FMA:18649 haploid nucleated cell cell haploid germ cell gamete true A mature sexual reproductive cell having a single set of unpaired chromosomes. GOC:tfm ISBN:0721662544 FBbt:00000092 cell pole cell OBSOLETE (was not defined before being made obsolete). cell Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. obsolete IgM B cell true OBSOLETE (was not defined before being made obsolete). cell Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead. obsolete IgG B cell true OBSOLETE (was not defined before being made obsolete). cell Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead. obsolete IgA B cell true OBSOLETE (was not defined before being made obsolete). cell Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. obsolete IgE B cell true FBbt:00004193 lens cell cell crystallin accumulating cell An epithelial cell found in the trachea. CL:1000474 FMA:74793 tracheocyte cell This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' tracheal epithelial cell true An epithelial cell found in the trachea. GOC:tfm cell metal ion accumulating cell cuprophilic cell cell copper accumulating cell cell iron accumulating cell cell keratin accumulating cell An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. CL:0002185 BTO:0000667 CALOHA:TS-0500 FMA:62879 keratinized cell of epidermis malpighian cell cell Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. keratinocyte true true An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. GOC:dsd MESH:A11.436.397 MESH:D015603 PMID:15582983 PMID:15749908 PMID:19727116 http://en.wikipedia.org/wiki/Keratinocyte Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. BTO:0003687 FMA:62511 serous cell cell serous secreting cell Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. GOC:tfm ISBN:0517223651 ISBN:0721662544 cell milk secreting cell A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea. cell tears secreting cell A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea. MESH:A12.200.882 Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem. cell replaced_by: PO:0000082 obsolete ray initial true Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem. ISBN:0471245208 A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris. sebocyte cell sebum secreting cell A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris. MESH:A12.200.702 A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products. cell sweat secreting cell A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products. MESH:A12.200.849 BTO:0003689 mucous cell cell mucus secreting cell Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell. archesporial cell megaspore mother cell cell replaced_by: PO:0000431 obsolete megasporocyte true Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell. ISBN:0471245208 cell seminal fluid secreting cell An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates. BTO:0000395 CALOHA:TS-2168 FMA:62499 alveolar epithelial cell pneumonocyte cell pneumocyte An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates. GOC:tfm PMID:20054144 cell lysozyme secreting cell cell metanephric mesenchyme stem cell A cell that is specialised to accumulate a particular substance(s). cell stuff accumulating cell A cell that is specialised to accumulate a particular substance(s). FB:ma cell glycogen accumulating cell cell extracellular matrix secreting cell cell myelin accumulating cell cell oxygen accumulating cell Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls. cell replaced_by: PO:0000075 obsolete collenchymal cell true Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls. ISBN:0471245208 Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements. cell replaced_by: PO:0000301 obsolete tracheid true Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements. ISBN:0471245208 OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair. cell non-hair cell replaced_by: PO:0020090 obsolete atrichoblast true OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair. ISBN:0387987819 A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. FMA:86667 cell migratory neural crest cell A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. MESH:A16.254.600 BTO:0002307 FAO:0000032 cell yeast-form vegetative cell (sensu Fungi) A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. cell mesenchyme condensation cell A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. GOC:tfm PMID:5025404 A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation. CL:1000422 FMA:69262 medullary chromaffin cell of adrenal gland cell adrenal medulla chromaffin cell A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation. GOC:tfm http://www.britannica.com/EBchecked/topic/6405/adrenal-gland medullary chromaffin cell of adrenal gland FMA:69262 An embryonic cell that develops into a nerve cell or neuron. cell neuroblast (sensu Vertebrata) An embryonic cell that develops into a nerve cell or neuron. FMA:70563 neuroblast cell neuroblast (sensu Nematoda and Protostomia) An early neural cell developing from the early ependymal cell of the neural tube. FMA:70564 spongioblast cell glioblast (sensu Vertebrata) An early neural cell developing from the early ependymal cell of the neural tube. GOC:tfm ISBN:0618947256 cell glioblast (sensu Nematoda and Protostomia) cell pigment cell (sensu Nematoda and Protostomia) Any animal cell containing pigment granules. cell pigment cell (sensu Vertebrata) Any animal cell containing pigment granules. GOC:tfm ISBN:0721662544 A pigment cell that is capable of detecting light stimulus that is involved in visual perception. FMA:63846 cell visual pigment cell (sensu Vertebrata) true A pigment cell that is capable of detecting light stimulus that is involved in visual perception. GOC:tfm cell obsolete non-visual cell (sensu Vertebrata) true A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp. cell Merge with odontoblast? dental papilla cell A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp. GOC:tfm ISBN:0721662544 A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling. cell Are these really all stem cells? hair follicle dermal papilla cell true A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling. GOC:tfm PMID:9893172 A cell of the sclera of the eye. cell scleral cell A cell of the sclera of the eye. GOC:add A cell of the choroid of the eye. cell choroidal cell of the eye A cell of the choroid of the eye. GOC:add cell extraembryonic cell cell amnioserosal cell A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. FMA:83028 trophoblastic cell cell trophoblast cell true A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. GOC:tfm MESH:A11.936 A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. cell epiblast cell A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. GOC:tfm ISBN:0618947256 An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). BTO:0001473 FMA:72551 blastomere cell blastoderm cell An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). MESH:A11.104 ncithesaurus:Blastemal_Cell blastema cell cell blastemal cell A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. FMA:86767 cell Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. multi-potent skeletal muscle stem cell true A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. PMID:18282570 cell hair matrix stem cell cell stratified epithelial stem cell A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. cell sphincter associated smooth muscle cell true A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. GOC:cjm A smooth muscle cell assocatiated with the vasculature. VSMC vascular smooth muscle cell cell vascular associated smooth muscle cell true A smooth muscle cell assocatiated with the vasculature. GOC:dsd GOC:tfm A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass. cell morula cell A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass. MESH:A16.254.270.550 A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers. cell gastrula cell A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers. MESH:A16.254.412 An epithelial cell of the integument (the outer layer of an organism). CL:1000396 BTO:0001470 CALOHA:TS-0283 FMA:62411 cell of epidermis epithelial cell of skin cell epidermal cell An epithelial cell of the integument (the outer layer of an organism). Flybase:dsj MA:ma cell of epidermis FMA:62411 epithelial cell of skin FMA:62411 Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system. cell replaced_by: PO:0000081 obsolete axial cell true Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system. ISBN:0471245208 Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues. cell obsolete ray cell true Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues. ISBN:0471245208 Diploid cell produced by the fusion of sperm cell nucleus and egg cell. zygote BTO:0000854 EHDAA2:0004546 FMA:72395 cell animal zygote Diploid cell produced by the fusion of sperm cell nucleus and egg cell. ISBN:0471245208 Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit. cell gametophyte sperm cell male gametophyte sperm cell pollen germ cell replaced_by: PO:0000084 obsolete sperm cell (sensu Viridiplantae) true Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit. ISBN:0471245208 cell glial cell (sensu Nematoda) sheath cell (sensu Nematoda) Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae. cell replaced_by: PO:0000352 obsolete myrosin cell true Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae. ISBN:0471245208 Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes. cell intermediary cell replaced_by: PO:0000078 obsolete transfer cell true Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes. ISBN:0471245208 The cell protoplasm after removal of the cell wall. cell protoplast The cell protoplasm after removal of the cell wall. ISBN:08199377X An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell. socket cell FBbt:00005171 cell tormogen cell An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell. ISBN:978-0801481253 socket cell ISBN:978-0801481253 FBbt:00001789 cell histoblast An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell. hair cell BTO:0004744 FBbt:00005169 cell trichogen cell An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell. ISBN:978-0801481253 CL:0007010 BTO:0002051 cell obsolete osteoprogenitor cell true cell humidity receptor cell cell tracheoblast cell support cell (sensu Nematoda and Protostomia) cell sensory processing neuron The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron. fly sheath cell cell thecogen cell The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron. Fbbt:00005173 FBbt:00005130 cell neurosecretory neuron FBbt:00005219 cell scolopale cell cell nephrogenic mesenchyme stem cell cell ligament cell FBbt:00005062 cell prohemocyte (sensu Nematoda and Protostomia) cell attachment cell FBbt:00005063 cell hemocyte (sensu Nematoda and Protostomia) PMID:18025161 An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance. muscle attachment cell cell tenocyte tendon cell true An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance. GOC:NV GOC:tfm PMID:957445 cell socket cell (sensu Nematoda) cell blood cell (sensu Nematoda and Protostomia) An insect immune cell that develops from plasmatocyte. FBbt:00001688 cell podocyte (sensu Diptera) An insect immune cell that develops from plasmatocyte. PMID:12930778 FMA:63847 cell crystal cell A cell whose function is determined by its response to an electric signal. cell electrically responsive cell A cell whose function is determined by its response to an electric signal. FB:ma FBbt:00001685 cell plasmatocyte FBbt:00001689 cell procrystal cell FBbt:00001687 cell lamellocyte cell ganglion interneuron true FBbt:00001691 cell polygonal cell Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion. cell obsolete phloem element true Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion. GOC:tfm Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina. cell replaced_by: PO:0000332 obsolete pavement cell true Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina. ISBN:087694289 FBbt:00001686 cell macrophage (sensu Diptera) cell CNS interneuron true A cell that initiates an electrical signal and passes that signal to another cell. cell electrically signaling cell A cell that initiates an electrical signal and passes that signal to another cell. FB:ma FBbt:00005148 cell neuroepidermoblast cell CNS short range interneuron FBbt:00005221 cell scolopidial ligament cell BTO:0001277 CALOHA:TS-0949 cell male gamete true true FBbt:00005219 cell scolopidial sheath cell cell CNS long range interneuron An epithelial cell of the hypodermis of flatworms. WBbt:0007846 cell flatworm hypodermal cell An epithelial cell of the hypodermis of flatworms. GOC:tfm http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm A cell whose nucleus, or nuclei, each contain more than two haploid genomes. cell polyploid cell A cell whose nucleus, or nuclei, each contain more than two haploid genomes. FB:ma A cell whose nucleus contains a single haploid genome. cell haploid cell A cell whose nucleus contains a single haploid genome. FB:ma GOC:tfm OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei. CL:0000000 CL:0000003 CL:0000255 CL:0001034 cell This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate. obsolete cell by ploidy true OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei. FB:ma GOC:tfm A cell whose nucleus has two haploid genomes. FMA:72300 cell diploid cell A cell whose nucleus has two haploid genomes. FB:ma cell polytene cell cell endopolyploid cell An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding. WBbt:0005793 cell arcade cell An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding. GOC:tfm http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells An epithelial fate stem cell found in flatworms. BTO:0003039 cell seam cell An epithelial fate stem cell found in flatworms. GOC:tfm http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm cell syncytial epithelial cell A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids. BTO:0002856 WBbt:0005751 cell coelomocyte A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids. GOC:tfm ISBN:0721662544 A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment. cell mitogenic signaling cell A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment. FB:ma cell tip cell A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids. WBbt:0005812 cell excretory cell A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids. GOC:tfm PMID:19783135 Forms the terminal part of the cuticle-lined excretory duct of C. elegans. cell pore cell Forms the terminal part of the cuticle-lined excretory duct of C. elegans. JB:jb cell scaffold cell A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role. cell GLR cell A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role. GOC:tfm http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm cell yolk cell cell imaginal disc cell A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red. cell xanthophore xanthophore cell A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red. SANBI:mhl A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color. cell guanophore iridophore A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color. SANBI:mhl Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum. FMA:62877 reticulum cell cell reticular cell Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum. GOC:tfm ISBN:0517223651 http://en.wikipedia.org/wiki/Reticular_cell Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis. cell replaced_by: PO:0000244 obsolete functional megaspore true Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis. TAIR:lr A secretory cell that discharges its product without loss of cytoplasm. cell eccrine cell A secretory cell that discharges its product without loss of cytoplasm. ISBN:0198547684 cell alkali secreting cell cell vaginal lubricant secreting cell A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH). BTO:0002482 FMA:83100 delta basophil follicle stimulating hormone secreting cell gonadotrope gonadotrope cell gonadotroph gonadotropic cell pituitary delta cell cell gonadtroph A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH). GOC:tfm ISBN:0517223651 http://en.wikipedia.org/wiki/Gonadotroph A peptide hormone secreting cell pituitary that produces luteinizing hormone. cell luteinizing hormone secreting cell A peptide hormone secreting cell pituitary that produces luteinizing hormone. GOC:tfm A peptide hormone cell that secretes prolactin. cell prolactin secreting cell A peptide hormone cell that secretes prolactin. GOC:tfm SANBI:mhl A cell of the intermediate pituitary that produces melanocyte stimulating hormone. BTO:0002277 melanotrope melanotroph cell melanocyte stimulating hormone secreting cell A cell of the intermediate pituitary that produces melanocyte stimulating hormone. SANBI:mhl FBbt:00004903 cell follicle stem cell A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response. BTO:0004267 FMA:83037 cell Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. follicular dendritic cell A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response. ISBN:127520252 cell calcitonin secreting cell A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern. cell Examples include the somatic muscles of nemotodes and cephalopods. obliquely striated muscle cell A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern. GOC:DOS PMID:8720463 cell apoptosis fated cell An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone. BTO:0004712 CALOHA:TS-2140 FMA:69078 parathyroid chief cell parathyroid gland chief cell parathyroid hormone secreting cell principal cell of parathyroid gland cell chief cell of parathyroid gland An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone. FMA:69078 GOC:tfm ISBN:0517223651 cell carbohydrate secreting cell Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole. CALOHA:TS-1119 FMA:83434 white adipose cell white fat cell cell white adipocyte white fat cell Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole. GOC:tfm MESH:A11.329.114.500 A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation. CALOHA:TS-0099 FMA:83435 brown adipocyte brown adipose cell cell brown fat cell A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation. MESH:A10.165.114.322 A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). BTO:0002042 CALOHA:TS-0194 FMA:83036 cell interdigitating cell veiled cell dendritic cell true A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). GOC:add ISBN:0781735149 cell thyroid hormone secreting cell Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus. BTO:0000705 CALOHA:TS-2375 FMA:63072 LC Langerhans' cell cell Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. Langerhans cell true Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus. GOC:add GOC:amm GO_REF:0000031 ISBN:0721601464 ISBN:0781735149 PMCID:PMC2346585 PMID:17850486 A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types. adrenaline secreting cell epinephrin secreting cell cell epinephrine secreting cell A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types. GOC:tfm PMID:12438093 adrenaline secreting cell GO:0048242 Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch. cell replaced_by: PO:0004531 obsolete starch sheath cell true Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch. ISBN:044174520 cell mineralocorticoid secreting cell cell biogenic amine secreting cell A cell type that secretes 5-Hydroxytryptamine (serotonin). 5-HT secreting cell 5-Hydroxytryptamine secreting cell cell serotonin secreting cell A cell type that secretes 5-Hydroxytryptamine (serotonin). GOC:tfm PMID:19630576 A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. noradrenaline secreting cell norepinephrin secreting cell norepinephrine secreting cell cell noradrenergic cell A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. GOC:tfm ISBN:068340007X cell glucocorticoid secreting cell FBbt:00003219 cell adepithelial cell An epidermal cell that secretes chitinous cuticle from its apical side. cell While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ. epidermal cell (sensu arthropoda) An epidermal cell that secretes chitinous cuticle from its apical side. FlyBase:ds ISBN:ISBN:978-0801481253 An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions. FBbt:00004994 cell epidermoblast An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions. GOC:tfm PMID:7576311 FBbt:00001666 cell cardioblast (sensu Arthropoda) A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin. CL:0000640 ACTH secreting cell adrenocorticotrophic hormone secreting cell corticotrophin hormone secreting cell corticotropin hormone secreting cell corticotropin secreting cell cell adrenocorticotropic hormone secreting cell A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin. GOC:tfm SANBI:mhl ACTH secreting cell GO:0051458 corticotropin secreting cell GO:0051458 FBbt:00005147 cell neuroglioblast FBbt:00005149 cell ganglion mother cell cell digestive enzyme secreting cell Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue. cell replaced_by: PO:0000076 obsolete chlorenchyma cell true Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue. ISBN:0471245208 A cell whose primary function is to protect the organism. cell defensive cell A cell whose primary function is to protect the organism. JB:jb an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. FBbt:00005058 pericardial cell cell pericardial nephrocyte an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. FBbt:00003184 GO:0061320 GOC:tfm PMID:19783135 pericardial cell FBbt:00005058 GO:0061320 Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis. cell replaced_by: PO:0000245 obsolete degenerate megaspore true Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis. TAIR:lr A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center. FMA:83099 beta-basophil thyroid stimulating hormone secreting cell thyrotrope cell thyrotroph A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center. ISBN:0517223651 SANBI:mhl FBbt:00004904 ovarian follicle cell cell Editors note: check this. Currently used in goxp follicle cell ovarian follicle cell GO:0007297 A peptide hormone secreting cell that secretes oxytocin stimulating hormone cell oxytocin stimulating hormone secreting cell A peptide hormone secreting cell that secretes oxytocin stimulating hormone GO:tfm A peptide hormone secreting cell that secretes vasopressin stimulating hormone cell vasopressin stimulating hormone secreting cell A peptide hormone secreting cell that secretes vasopressin stimulating hormone GO:tfm A peptide hormone secreting cell that secretes secretin stimulating hormone cell secretin stimulating hormone secreting cell A peptide hormone secreting cell that secretes secretin stimulating hormone GO:tfm A peptide hormone secreting cell that secretes cholecystokin stimulating hormone cell cholecystokin stimulating hormone secreting cell A peptide hormone secreting cell that secretes cholecystokin stimulating hormone GO:tfm An endocrine cell that secretes juvenile hormone. cell juvenile hormone secreting cell An endocrine cell that secretes juvenile hormone. GO:tfm A peptide hormone secreting cell that secretes cholecystokin stimulating hormone cell bombesin stimulating hormone secreting cell A peptide hormone secreting cell that secretes cholecystokin stimulating hormone GO:tfm Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent. MC(TC) MCTC TC mast cells cell They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. connective tissue type mast cell true Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent. GOC:add GOC:dsd GOC:tfm PMID:19923473 PMID:9354811 Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype. MC(T) MCT T mast cells cell They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. mucosal type mast cell true Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype. GOC:add GOC:dsd PMID:19923473 PMID:9354811 A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae. garland nephrocyte BTO:0004596 FBbt:00005059 cell garland cell A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae. GOC:tfm PMID:19783135 fbbt:00005059 garland nephrocyte GO:0061321 A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments. FBbt:00004995 cell oenocyte A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments. GOC:bf PMID:11171397 A photoreceptor cell that detects visible light. cell visible light photoreceptor cell A photoreceptor cell that detects visible light. GOC:tfm cell scotopic photoreceptor cell cell photopic photoreceptor cell OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody. cell This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation. obsolete cytotoxic T cell true A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions. CALOHA:TS-1146 FMA:70572 CD4-positive T-helper cell CD4-positive helper T lymphocyte CD4-positive helper T-cell CD4-positive helper T-lymphocyte cell CD4-positive helper T cell true A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions. GOC:add GOC:pam GOC:tfm GO_REF:0000031 ISBN:0781735149 MESH:A11.118.637.555.567.569.200.400 OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses. cell This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead. obsolete regulatory T cell true A photoreceptor cell that detects ultraviolet light. cell UV sensitive photoreceptor cell A photoreceptor cell that detects ultraviolet light. GOC:tfm A photoreceptor cell that is sensitive to blue light. cell blue sensitive photoreceptor cell A photoreceptor cell that is sensitive to blue light. GO:tfm A photoreceptor cell that is sensitive to green light. cell green sensitive photoreceptor cell A photoreceptor cell that is sensitive to green light. GO:tfm A photoreceptor cell that is sensitive to red light. cell red sensitive photoreceptor cell A photoreceptor cell that is sensitive to red light. GO:tfm An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS). FMA:84776 cell inhibitory interneuron An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS). GOC:tfm http://en.wikipedia.org/wiki/Interneuron A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. BTO:0002064 FMA:83624 cell stromal cell A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. GOC:tfm MESH:A11.329.830 cell follicular epithelial cell A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors. BTO:0000542 CALOHA:TS-0729 FMA:18718 granulosa cell of ovary cell granulosa cell A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors. MESH:A05.360.319.114.630.535.200 A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. FMA:62935 D cell cell type D enteroendocrine cell A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. MESH:A03.492.766.440.175 A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells. BTO:0002850 FMA:18690 cell theca cell A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells. MESH:A05.360.319.114.630.535.400 A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells. BTO:0002692 ECL cell Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell. enterochromaffin-like cell A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells. GOC:tfm MESH:A06.224.365 A peptide hormone secreting cell that secretes substance P. cell substance P secreting cell A peptide hormone secreting cell that secretes substance P. GO:tfm An endorphine cell that secretes enkephalin. cell enkephalin secreting cell An endorphine cell that secretes enkephalin. GO:tfm A peptide hormone secreting cell that secretes endorphin. cell endorphin secreting cell A peptide hormone secreting cell that secretes endorphin. GO:tfm An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. BTO:0004108 FMA:67609 G cell cell type G enteroendocrine cell An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. GOC:tfm ISBN:0517223651 MESH:A03.492.766.440.300 A peptide hormone secreting cell that secretes gastrin. cell gastrin secreting cell A peptide hormone secreting cell that secretes gastrin. GO:tfm An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix. BTO:0000993 FMA:62897 cell paneth cell true An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix. GOC:tfm ISBN:0517223651 MESH:A03.492.411.369.700 A peptide hormone secreting cell that secretes androgen binding protein. cell androgen binding protein secreting cell A peptide hormone secreting cell that secretes androgen binding protein. GO:tfm A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it. cell paracrine cell A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it. GOC:tfm ISBN:0198529171 A precursor cell destined to differentiate into cardiac muscle cell. CL:0000714 FMA:84797 cardiac muscle progenitor cell cardiomyocyte progenitor cell cell cardiac muscle myoblast A precursor cell destined to differentiate into cardiac muscle cell. GOC:tfm MESH:A11.635.470 A precursor cell destined to differentiate into smooth muscle myocytes. FMA:84798 myoblast, smooth muscle cell satellite cell smooth muscle myoblast true A precursor cell destined to differentiate into smooth muscle myocytes. GOC:tfm MESH:A11.635.510 MESH:D032390 myoblast, smooth muscle MESH:D032390 A myoblast that differentiates into skeletal muscle fibers. FMA:84799 skeletal myoblast cell skeletal muscle myoblast true A myoblast that differentiates into skeletal muscle fibers. SANBI:mhl A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia. FMA:54550 perineural satellite cell perineuronal satellite oligodendroglial cell satellite oligodendrocyte cell perineuronal satellite cell A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia. GOC:tfm MESH:A08.340.685 A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions. cell macrophage derived foam cell A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions. GOC:add PMID:20213546 A phagocyte in vertebrates that is able to phagocytosis. cell phagocyte (sensu Vertebrata) A phagocyte in vertebrates that is able to phagocytosis. GOC:tfm A phagocyte from organisms in the Nematoda or Protostomia clades. cell phagocyte (sensu Nematoda and Protostomia) A phagocyte from organisms in the Nematoda or Protostomia clades. GOC:tfm cell prokaryotic cell cell fungal cell OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms. cell obsolete spore true OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms. ISBN:08199377X A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast. FMA:83042 Langhans' cell cell mononuclear cytotrophoblast cell A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast. GOC:tfm ISBN:0323052908 A cell, usually of bacteria or yeast, which has partially lost its cell wall. sphaeroplast cell spheroplast A cell, usually of bacteria or yeast, which has partially lost its cell wall. MESH:A11.868 A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. FMA:83043 plasmidotrophoblast syncytial trophoblast syntrophoblast cell syncytiotrophoblast cell A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. GOC:tfm ISBN:0323052908 A neuron which conveys sensory information centrally from the periphery. FMA:87653 input neuron cell afferent neuron A neuron which conveys sensory information centrally from the periphery. GOC:tfm MESH:A08.663.650 A neuron which sends impulses peripherally to activate muscles or secretory cells. output neuron cell efferent neuron A neuron which sends impulses peripherally to activate muscles or secretory cells. MESH:A08.663.655 A nerve cell where transmission is mediated by nitric oxide. FMA:84792 cell nitrergic neuron A nerve cell where transmission is mediated by nitric oxide. MESH:A08.663.748 cell pigmented epithelial cell cell primary neuron cell primary sensory neuron cell CAP motoneuron FMA:83619 cell primary motor neuron cell primary interneuron cell secondary neuron FMA:83620 cell secondary motor neuron Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms. cell replaced_by: PO:0020093 obsolete antipodal cell true Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms. ISBN:047125208 Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis. cell replaced_by: PO:0000349 obsolete epidermal initial true Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis. TAIR:lr OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue. cell obsolete idioblast true OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue. ISBN:0471245208 The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. BTO:0000938 CALOHA:TS-0683 FBbt:00005106 FMA:54527 VHOG:0001483 WBbt:0003679 nerve cell cell These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. MESH:A08.663 MESH:D009474 http://en.wikipedia.org/wiki/Neuron A cell that originates from the neural crest and differentiates into a pigment cell. BTO:0003217 FMA:83377 cell Derived from UBERON:0002342 neural crest. melanoblast A cell that originates from the neural crest and differentiates into a pigment cell. GOC:tfm SANBI:mhl A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. BTO:0000775 CALOHA:TS-0583 FMA:62863 VHOG:0001535 cell Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) lymphocyte A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. GOC:add ISBN:0683073696 ISBN:0781735149 Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment. sieve tube element cell replaced_by: PO:0000289 obsolete sieve tube member true Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment. ISBN:0471245208 cell slowly adapting mechanoreceptor cell A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma. BTO:0001678 FMA:84382 T helper cells type 1 T(H)-1 cell Th1 CD4+ T cell Th1 T cell Th1 T lymphocyte Th1 T-cell Th1 T-lymphocyte Th1 cell helper T cell type 1 cell This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells. T-helper 1 cell true A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19375293 PMID:20303875 PMID:22343568 T helper cells type 1 PMID:9419219 Th1 CD4+ T cell PMID:22343568 A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4. BTO:0001679 FMA:84385 T helper cells type 2 T(H)-2 cell Th2 T cell Th2 T lymphocyte Th2 T-cell Th2 T-lymphocyte Th2 cell helper T cell type 2 cell This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell. T-helper 2 cell true A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19375293 PMID:20103781 PMID:22343568 T helper cells type 2 PMID:9419219 An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. FMA:83518 rubriblast cell pronormoblast proerythroblast true An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. ISBN:0721601464 MESH:A11.118.290.350.200 PMID:1638021 rubriblast ISBN:0721601464 cell animal cell A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. FMA:83505 basophilic normoblast early erythroblast early normoblast prorubricyte cell basophilic erythroblast true A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. GOC:tfm ISBN:0721601464 basophilic normoblast ISBN:0721601464 early erythroblast ISBN:0721601464 early normoblast ISBN:0721601464 prorubricyte ISBN:0721601464 A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. FMA:83506 intermediate erythroblast intermediate normoblast polychromatic erythroblast polychromatic normoblast polychromatophilic normoblast rubricyte cell polychromatophilic erythroblast true A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. ISBN:0721601464 intermediate erythroblast ISBN:0721601464 intermediate normoblast ISBN:0721601464 polychromatic erythroblast ISBN:0721601464 polychromatic normoblast ISBN:0721601464 polychromatophilic normoblast ISBN:0721601464 rubricyte ISBN:0721601464 cell unimodal nocireceptor The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. FMA:84646 acidophilic erythroblast eosinophilic erythroblast late erythoblast orthochromatic normoblast pyknotic eto enrythroblast cell orthochromatic erythroblast true The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. ISBN:0721601464 acidophilic erythroblast ISBN:0721601464 eosinophilic erythroblast ISBN:0721601464 orthochromatic normoblast ISBN:0721601464 pyknotic eto enrythroblast ISBN:0721601464 The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). BTO:0001164 CALOHA:TS-0610 FMA:84235 CFU-Meg Meg-CFC MkP colony-forming unit-megakaryocyte megacaryoblast megacaryocyte progenitor cell megakaryoblast megakaryocytic progenitor cell cell promegacaryocyte promegakaryocyte Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. megakaryocyte progenitor cell true The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). GOC:dsd GOC:tfm ISBN:0721601464 CFU-Meg PMID:11722431 PMID:12482498 Meg-CFC PMCID:PMC1794060 MkP PMID:21116988 megakaryocytic progenitor cell PMID:12482498 A peptide hormone secreting cell that secretes gastrin stimulating hormone. cell gastrin stimulating hormone secreting cell A peptide hormone secreting cell that secretes gastrin stimulating hormone. GOC:tfm cell neuronal brush cell A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm. BTO:0000843 CALOHA:TS-0611 FMA:83555 megacaryocyte megalocaryocyte megalokaryocyte cell Megakaryocytes are reportedly CD181-positive and CD182-positive. megakaryocyte true A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm. ISBN:0721601464 MESH:D008533 http://en.wikipedia.org/wiki/Megakaryocyte A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. CFU-C , Colony forming unit in culture CFU-GM GMP colony forming unit granulocyte macrophage granulocyte-macrophage progenitor granulocyte/monocyte precursor granulocyte/monocyte progenitor cell Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. GOC:amm GOC:dsd GOC:tfm GO_REF:0000031 ISBN:0721601464 MESH:D055014 PMCID:PMC2213186 PMCID:PMC548021 PMID:16551251 PMID:16647566 http://en.wikipedia.org/wiki/CFU-GM http://www.copewithcytokines.de CFU-C , Colony forming unit in culture http://www.copewithcytokines.de CFU-GM ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 GMP ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 colony forming unit granulocyte macrophage ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 granulocyte-macrophage progenitor ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. BTO:0001173 CALOHA:TS-0864 cell reticulocyte true An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. GOC:add GOC:tfm PMID:15946868 PMID:2037622 A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules. BTO:0004657 FMA:83551 cell Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. promonocyte true A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules. GOC:tfm ISBN:0721601464 A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative. band band cell band form stab cell rod neutrophil cell Found in the Band 1 fraction. band form neutrophil true A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative. GOC:add GOC:dsd GOC:tfm ISBN:0721601464 PMID:10618520 PMID:12560239 PMID:15514007 http://www.cap.org Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons. BTO:0004044 FBbt:00005127 FMA:67766 amacrine neuron cell Not clear if this term overlaps with retinal bipolar neuron (CL:0000748). amacrine cell Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons. GOC:tfm MESH:A08.663.358.050 An erythrocyte having a nucleus. RBC red blood cell cell nucleate erythrocyte true An erythrocyte having a nucleus. GOC:add GOc:tfm A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged. BTO:0002779 bacterial spore cell endospore A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged. GOC:tfm ISBN:0618947256 A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression. FMA:84196 neutrophilic premyelocyte neutrophilic progranulocyte cell These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. neutrophilic promyelocyte true A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression. GOC:add GOC:dsd GOC:tfm ISBN:0721601464 PMID:12560239 PMID:15514007 A cell found in fat bodies whose primary function is intermediary metabolism. cell fat body cell A cell found in fat bodies whose primary function is intermediary metabolism. FB:ma A mesenchymal stem cell capable of developing into blood vessel endothelium. angioblast chondroplast cell These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. angioblastic mesenchymal cell true A mesenchymal stem cell capable of developing into blood vessel endothelium. GOC:dsd GOC:tfm PMID:12768659 cell polymodal nocireceptor A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell. BTO:0003866 FMA:83114 APUD cell cell amine precursor uptake and decarboxylation cell A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell. GOC:tfm ISBN:0721662544 MESH:A11.070 A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. cell cardiac mesenchymal cell A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. PMID:18816864 A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine. FMA:68653 SCTID:176770005 C cell C cell of thyroid gland clear cell of thyroid gland parafollicular cell of thyroid gland thyroid parafollicular cell cell parafollicular cell true true A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine. GOC:tfm ISBN:0517223651 C cell of thyroid gland FMA:68653 clear cell of thyroid gland FMA:68653 parafollicular cell of thyroid gland FMA:68653 thyroid parafollicular cell FMA:68653 A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light. cell leucophore A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light. SANBI:mhl One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. BTO:0001036 CALOHA:TS-0866 FMA:67748 cell retinal cone cell One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. MESH:A08.663.650.650.670.100 A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance. cell erythrophore A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance. SANBI:mhl An epithelial cell of the cornea. CL:1000431 BTO:0004298 CALOHA:TS-0173 FMA:70551 epithelial cell of cornea cell corneal epithelial cell true An epithelial cell of the cornea. GOC:tfm epithelial cell of cornea FMA:70551 Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. BTO:0000876 CALOHA:TS-0638 FMA:62864 cell Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. monocyte true Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. GO_REF:0000031 MESH:A11.118.637.555.652 A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain). CL:0002065 FMA:62934 FMA:83132 Kulchitsky cell argentaffin cell enterochromaffin cell cell type EC enteroendocrine cell A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain). MESH:A03.492.766.440.250 PMID:9505449 A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure. cell This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12 experimentally modified cell in vitro A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure. FB:ma ReO:mhb FBbt:00004905 cell border follicle cell A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive. BTO:0003455 FMA:83540 cell These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. neutrophilic myelocyte true A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive. GOC:add GOC:dsd GOC:tfm ISBN:0721601464 PMID:10618520 PMID:12560239 PMID:15514007 http://www.cap.org A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive. BTO:0001034 FMA:83025 cell Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. peritoneal macrophage true A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive. MESH:A11.329.372.630 PMID:15771589 PMID:19201820 A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin. FMA:84197 juvenile neutrophil cell These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. neutrophilic metamyelocyte true A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin. GOC:add GOC:dsd GOC:tfm ISBN:0721601464 PMID:10618520 PMID:12560239 PMID:15514007 http://www.cap.org A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. BTO:0000802 CALOHA:TS-0030 FMA:83023 dust cell cell MF.Lu Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. alveolar macrophage true A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. GOC:ana GOC:dsd GOC:tfm GO_REF:0000031 MESH:A11.329.372.600 An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen. BTO:0000398 FMA:62122 cell enterocyte An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen. SANBI:mhl OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells. cell This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context. obsolete null cell true The reproductive cell in multicellular organisms. BTO:0000535 VHOG:0001534 WBbt:0006796 cell germ cell true The reproductive cell in multicellular organisms. MESH:A05.360.490 A thermoreceptor cell that detects reduced temperatures. cell cold sensing thermoreceptor cell A thermoreceptor cell that detects reduced temperatures. GOC:tfm A specialized osteoclast associated with the absorption and removal of cementum. BTO:0002516 FMA:83027 cell odontoclast true A specialized osteoclast associated with the absorption and removal of cementum. GOC:add MESH:A11.329.679 A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated. inner hair cell BTO:0003667 FMA:62365 cell cochlear inner hair cell A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated. MESH:A08.663.650.250.250 A progesterone secreting cell in the corpus luteum that develops from theca cells. BTO:0002850 FMA:18690 small lutein cell theca lutein cell cell small luteal cell A progesterone secreting cell in the corpus luteum that develops from theca cells. GOC:tfm MESH:A05.360.319.114.630.278.400 A thermoreceptor cell that detects reduced temperatures. cell warmth sensing thermoreceptor cell A thermoreceptor cell that detects reduced temperatures. GOC:tfm A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells. FMA:18689 granulosa lutein cell cell granulosoluteocytus large luteal cell A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells. GOC:tfm MESH:A05.360.319.114.630.278.400 A steroid hormone secreting cell that secretes androgen. cell androgen secreting cell A steroid hormone secreting cell that secretes androgen. GOC:tfm An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers. cell Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population. skeletal muscle satellite cell An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers. GOC:tfm MESH:A11.635.500.700 PMID:21849021 PMID:23303905 An erythrocyte lacking a nucleus. RBC red blood cell cell enucleate erythrocyte true An erythrocyte lacking a nucleus. GOC:add GOC:tfm A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature. FAO:0000017 meiotically-derived spore cell sexual spore A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature. FAO:0000017 GOC:tfm SGD:clt The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall. FAO:0000028 cell microconidium The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall. GOC:tfm ISBN:0471940526 PMID:8357339 SGD:clt Pyramidal neurons have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala. BTO:0003102 FMA:67310 FMA:86775 NIFSTD:sao862606388 projection neuron pyramidal cell pyramidal neuron cell pyramidal neuron Pyramidal neurons have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala. GOC:tfm MESH:A08.186.211.577.405.700 An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm. BTO:0000283 FAO:0000024 cell conidium An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm. ISBN:08199377X PMID:2524423 PMID:9529886 SGD:clt A fungal cell with two or more genetically distinct nuclei. cell heterokaryon A fungal cell with two or more genetically distinct nuclei. ISBN:08199377X A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea. BTO:0003666 FMA:62366 cochlear outer hair cell cell outer hair cell A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea. MESH:A08.663.650.250.315 A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls. cell pressoreceptor cell A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls. MESH:A08.800.050.800.900.700 A fungal cell with two genetically distinct haploid nuclei. cell dikaryon A fungal cell with two genetically distinct haploid nuclei. ISBN:08199377X One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. BTO:0001024 CALOHA:TS-0870 FMA:67747 cell retinal rod cell One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. MESH:A08.663.650.650.670.650 A spore formed following mitosis or mitoses. FAO:0000023 cell fungal asexual spore A spore formed following mitosis or mitoses. GOC:tfm PMID:2524423 PMID:9529886 SGD:clt The larger of two types of asexual spores formed by some fungi; usually round or oblong. FAO:0000038 cell macroconidium The larger of two types of asexual spores formed by some fungi; usually round or oblong. GOC:tfm ISBN:0471940526 SGD:clt A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete. BTO:0000097 FAO:0000020 cell ascospore A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete. GOC:tfm ISBN:08199377X SGD:clt A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium. FAO:0000040 cell zygospore A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium. ISBN:0471940526 ISBN:08199377X SGD:clt A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem. FMA:62351 vestibular receptor cell cell vestibular hair cell A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem. GOC:tfm MESH:A08.663.650.250.380 PO:0009002 cell This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO) obsolete plant cell true EoP cell CFU-Eo colony forming unit eosinophil eosinophil stem cell These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76). eosinophil progenitor cell true EoP PMCID:PMC2212039 PMCID:PMC2626675 A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive. BTO:0003454 FMA:83542 cell eosinophilic myelocyte true A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive. GOC:add GOC:dsd ISBN:0721601464 PMID:19622087 http://www.cap.org A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa. BaP cell CFU-Bas basophilic stem cell colony forming unit basophil BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf). basophil progenitor cell true A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa. GOC:add GOC:dsd PMCID:PMC1312421 http://www.copewithcytokines.de A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive. BTO:0003456 FMA:83543 cell basophilic myelocyte true A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive. GOC:add GOC:tfm ISBN:0721601464 PMID:18466030 http://www.cap.org A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium. BTO:0002166 FAO:0000021 cell basidiospore A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium. GOC:clt ISBN:0471940526 ISBN:08199377X OBSOLETE: A walled spore produced in a sporangium. cell obsolete sporangiospore true OBSOLETE: A walled spore produced in a sporangium. ISBN:08199377X A neuron that uses GABA as a vesicular neurotransmitter FMA:84788 WBbt:0005190 GABA-ergic neuron cell GABAergic neuron A neuron that uses GABA as a vesicular neurotransmitter GOC:tfm cell sheath cell cell support cell (sensu Nematoda) OBSOLETE: A sporangiospore that is motile, having flagella. FAO:0000039 cell obsolete zoospore true OBSOLETE: A sporangiospore that is motile, having flagella. ISBN:08199377X A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006). cell fusion competent myoblast A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006). PMID:22274696 A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). FMA:83625 acinic cell acinous cell cell acinar cell A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). GOC:tfm http://www.copewithcytokines.de A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells. large granular lymphocyte null cell BTO:0000914 BTO:0004716 CALOHA:TS-0664 FMA:63147 FMA:83601 VHOG:0001697 NK cell cell natural killer cell true A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells. GOC:add ISBN:0781735149 PMID:15771571 A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor. CD4-positive, alpha-beta T lymphocyte CD4-positive, alpha-beta T-cell CD4-positive, alpha-beta T-lymphocyte cell CD4-positive, alpha-beta T cell true A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor. GOC:add ISBN:0781735149 A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor. CD8-positive, alpha-beta T lymphocyte CD8-positive, alpha-beta T-cell CD8-positive, alpha-beta T-lymphocyte cell CD8-positive, alpha-beta T cell true A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor. GOC:add GOC:tfm ISBN:0781735149 Granule cell that is part of the olfactory bulb. cell olfactory granule cell Granule cell that is part of the olfactory bulb. GOC:mah A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances. cell transporting cell A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances. TAIR:sr A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source. cell see PMID:21177950, The making of a photosynthetic animal. photosynthetic cell A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source. TAIR:sr A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose. cell storage cell A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose. FB:ma A cell whose primary function is to support other cell types. BTO:0002315 cell supportive cell A cell whose primary function is to support other cell types. FB:ma GOC:tfm Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen. cell labyrinth supporting cell Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen. MESH:A09.246.631.246.577.543 A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. BTO:0002741 CALOHA:TS-0452 FMA:67763 Ito cell hepatic perisinusoidal cell perisinusoidal cell cell fat-storing cell lipocyte vitamin A-storing cells Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. hepatic stellate cell A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. GOC:dsd MESH:D055166 PMID:12808230 PMID:17239632 PMID:18222966 PMID:9302568 http://en.wikipedia.org/wiki/Hepatic_stellate_cell vitamin A-storing cells PMID:12808230 A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti. FMA:79799 Hensen's cell cell of Hensen external limiting cell of organ of Corti cell Hensen cell A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti. GOC:tfm ISBN:0721662544 A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti. FMA:79802 cell of Claudius external supporting cell of vestibular epithelium cell external supporting cell of Claudius Claudius cell A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti. GOC:tfm ISBN:0721662544 The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression. FMA:75725 Deiters cell outer phalangeal cell cell Deiter's cell The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression. GOC:tfm ISBN:0721662544 http://www.britannica.com/EBchecked/topic/156177/Deiters-cell BTO:0003064 cell Mueller cell A cell that stains readily in the anterior pituitary gland. FMA:83089 cell chromophil cell of anterior pituitary gland A cell that stains readily in the anterior pituitary gland. GOC:tfm ISBN:0618947256 An acidophilic chromophil cell that of the anterior pituitary gland. FMA:83093 acidophil cell of pars anterior of adenohypophysis acidophil of pars anterior of adenohypophysis acidophil of pars distalis of adenohypophysis pituitary alpha cell cell acidophil cell of pars distalis of adenohypophysis An acidophilic chromophil cell that of the anterior pituitary gland. GOC:tfm A basophillic chromophil cell that of the anterior pituitary gland. FMA:83094 basophil cell of anterior lobe of hypophysis cell beta cell pituitary beta cell basophil cell of pars distalis of adenohypophysis A basophillic chromophil cell that of the anterior pituitary gland. GOC:tfm A cell that is resistant to stains. FMA:83626 chromophobic cell cell chromophobe cell A cell that is resistant to stains. GOC:tfm A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones. cell folliculostellate cell A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones. JB:jb Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses. FMA:54559 Bergmann astrocyte Bergmann glial cell of cerebellum cell Bergmann glial cell Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses. GOC:tfm http://www.neurolex.org/wiki/Category:Bergmann_Glial_Cell A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment. BTO:0003793 FMA:83503 cell pituicyte A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment. ISBN:0412046911 ISBN:0517223651 http://en.wikipedia.org/wiki/Pituicyte Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament. BTO:0000939 FMA:62516 cell basal cell Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament. GOC:tfm ISBN:0517223651 A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes. BTO:0003107 FMA:83035 Langerhans giant cell foreign body giant cell macrophage polykaryon multinucleate giant cell syncytial giant cell cell Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this. multinucleated giant cell true A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes. GOC:add GOC:tfm ISBN:0702022918 ISBN:0702024783 Langerhans giant cell ISBN:0702022918 ISBN:0702024783 foreign body giant cell ISBN:0702022918 ISBN:0702024783 macrophage polykaryon ISBN:0702022918 ISBN:0702024783 multinucleate giant cell ISBN:0702022918 ISBN:0702024783 syncytial giant cell ISBN:0702022918 ISBN:0702024783 A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation. CL:0000461 juxtaglomerular cell FMA:84138 JG cell renin secreting cell cell kidney granular cell A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation. GOC:cvs GOC:tfm PMID:11457727 A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin. CL:0002186 FMA:69059 prickle cell of epidermis cell prickle cell A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin. GOC:tfm ISBN:0721662544 ISBN:0815332181 A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries. BTO:0000853 CALOHA:TS-0617 FMA:70972 kidney mesangial cell cell Do all of these cells really develop from some mesenchymal stem cell? mesangial cell A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries. GOC:tfm http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands neck cell cell mucous neck cell A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands GOC:tfm This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation. BTO:0001068 FMA:83417 cell pinealocyte This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation. GOC:tfm ISBN:0517223651 PMID:16687276 http://en.wikipedia.org/wiki/Pinealocyte A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells. epithelial cell of visceral layer of glomerular capsule BTO:0002295 glomerular podocyte podocyte cell GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm]. glomerular visceral epithelial cell A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells. GOC:tfm epithelial cell of visceral layer of glomerular capsule FMA:70967 glomerular podocyte FMA:70967 A primary oocyte is an oocyte that has not completed female meosis I. BTO:0000512 FMA:18645 cell primary oogonium primary oocyte true A primary oocyte is an oocyte that has not completed female meosis I. GOC:tfm ISBN:0721662544 A secondary oocyte is an oocyte that has not completed meiosis II. BTO:0003094 FMA:18646 cell primary oogonium secondary oocyte true A secondary oocyte is an oocyte that has not completed meiosis II. GOC:tfm ISBN:0721662544 A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes. BTO:0001115 CALOHA:TS-2194 FMA:72292 cell primary spermatocyte true A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes. GOC:tfm ISBN:0721662544 One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids. BTO:0000709 CALOHA:TS-2195 FBbt:00004941 FMA:72293 cell secondary spermatocyte true One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids. GOC:tfm ISBN:0721662544 An epithelial cell that secretes cuticle. cell cuticle secreting cell An epithelial cell that secretes cuticle. GOC:tfm An extracellular matrix secreting cell that secretes eggshell. cell eggshell secreting cell An extracellular matrix secreting cell that secretes eggshell. GOC:tfm An extracellular matrix secreting cell that secretes glycocalyx. cell glycocalyx secreting cell An extracellular matrix secreting cell that secretes glycocalyx. GOC:tfm cell distal tip cell (sensu Nematoda) cell neuroglioblast (sensu Nematoda) cell valve cell cell closable valve cell cell permanently open valve cell window cell cell fenestrated cell An extracellular matrix secreting cell that secretes collagen. cell collagen secreting cell An extracellular matrix secreting cell that secretes collagen. GOC:tfm OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues. BTO:0002174 FMA:84638 cell OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074. obsolete parenchymal cell true OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues. ISBN:0471245208 An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. CL:0000184 BTO:0002441 FMA:63174 ARC adventitial reticular cell cell of Rouget pericyte pericyte of Rouget cell adventitial cell Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. pericyte cell An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. GOC:dsd GOC:tfm ISBN:0721662544 MESH:D020286 PMID:16807374 PMID:17986482 PMID:20024907 ARC PMID:17986482 A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. FMA:70567 gonocyte primitive germ cell cell primordial germ cell true true A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. GOC:tfm PMID:1381289 FBbt:00004906 cell centripetally migrating follicle cell Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member. cell replaced_by: PO:0000290 obsolete tracheary element true Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member. ISBN:0471245208 cell Kenyon cell FBbt:00004910 fly stalk cell cell interfollicle cell A mature sexual reproductive cell of the female germline. cell female gamete true A mature sexual reproductive cell of the female germline. GOC:tfm BTO:0001033 cell cap cell Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules. cell gut absorptive cell Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules. JB:jb cell commissural neuron WBbt:0006829 cell glutamatergic neuron A non-terminally differentiated cell that is capable of developing into a muscle cell. cell muscle precursor cell A non-terminally differentiated cell that is capable of developing into a muscle cell. GOC:add A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration. forebrain radial glial cell cell Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life. radial glial cell A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration. GOC:dph An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes. M cell BTO:0003600 FMA:62929 M-cell microfold cell cell Should double check and see if M cells are particular to a specific region. M cell of gut An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes. GOC:jb GOC:tfm A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space. ependymal astrocyte cell ependymoglial cell A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space. JB:jb http://neurolex.org/wiki/Category:Ependymoglial_Cell cell littoral cell of liver Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall. cell replaced_by: PO:0004010 obsolete meristematic cell true Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall. PO:0004010 A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid. cell cerebrospinal fluid secreting cell true A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid. GOC:tfm R1 cell cell R1 photoreceptor cell A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina. cell perijunctional fibroblast A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina. JB:jb A cell with both myofibrils and secretory granules. cell myoendocrine cell A cell with both myofibrils and secretory granules. JB:jb R2 cell cell R2 photoreceptor cell cell stellate interneuron A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse. Schwann cell cell terminal Schwann cell A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse. JB:jb PMID:16136171 A stellate interneuron having 7-10 dendrites that may branch. spiderweb cell cell neuroglioform cell A stellate interneuron having 7-10 dendrites that may branch. JB:jb R3 cell cell R3 photoreceptor cell One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene. cell Cajal-Retzius cell One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene. PMID:10600995 PMID:9728912 A cell that stores and secretes pancreatic polypeptide hormone. FMA:62938 FMA:83409 type F enteroendocrine cell cell PP cell A cell that stores and secretes pancreatic polypeptide hormone. GOC:tfm JB:jb PMID:15153415 R4 cell cell R4 photoreceptor cell cell obsolete paraganglial cell true A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines. cell paraganglial type 1 cell A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines. GOC:tfm A neuron that releases dopamine as a neurotransmitter. BTO:0004032 FMA:84787 WBbt:0006746 dopaminergic cell cell dopaminergic neuron A neuron that releases dopamine as a neurotransmitter. GOC:dhill Supports paraganglial type 1 cell. cell paraganglia type 2 cell Supports paraganglial type 1 cell. JB:jb R5 cell cell R5 photoreceptor cell Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors. BTO:0002315 cell sustentacular cell Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors. JB:jb A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels. cell endothelial tip cell A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels. PMID:15376331 R6 cell cell R6 photoreceptor cell Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord. CL:1000430 FMA:70549 epithelial cell of choroid plexus cell choroid plexus epithelial cell Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord. GOC:add GOC:tfm JB:jb PMID:9550134 R7 cell cell R7 photoreceptor cell Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus. cell leptomemingeal cell leptomeningeal cell true Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus. JB:jb R8 cell cell R8 photoreceptor cell Epithelial cells derived from neural plate and neural crest. neuroepithelial cell BTO:0004301 FMA:70557 cell The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). neurecto-epithelial cell Epithelial cells derived from neural plate and neural crest. GOC:tfm Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle. BTO:0002236 cell cumulus cell Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle. GOC:tfm http://www.copewithcytokines.org/cope.cgi?key=cumulus%20cells cell stratum granulosum cell cell corona radiata cell cell embryonic crystal cell cell lymph gland crystal cell A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons. cell fusimotor neuron A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons. PMID:15582775 cell cone cell (sensu Endopterygota) compound eye cone cell cell posterior cone cell (sensu Endopterygota) cell anterior cone cell (sensu Endopterygota) cell equatorial cone cell (sensu Endopterygota) cell cystoblast A stem cell that can give rise to cell types of the body other than those of the germ-line. CALOHA:TS-2086 FMA:63368 cell somatic stem cell true A stem cell that can give rise to cell types of the body other than those of the germ-line. GO:0048103 A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions. BTO:0000600 cell heterocyst A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions. MA:ma cell nitrogen fixing cell An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material. cell Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus. chlamydospore An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material. GOC:tfm ISBN:085199377X cell primary pigment cell cell secondary pigment cell cell tertiary pigment cell A cell at the front of a migrating epithelial sheet. cell leading edge cell A cell at the front of a migrating epithelial sheet. MA:ma A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria. FMA:84127 bladder transitional cell transitional epithelial cell of urinary bladder urinary tract transitional epithelial cell cell urothelial cell true A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria. GOC:tfm MA:ma cell amoeboid cell cell lymph gland plasmatocyte cell embryonic gland plasmatocyte cell lymph gland hemocyte cell embryonic gland hemocyte Muscle cell which has as its direct parts myofilaments organized into sarcomeres. BTO:0002916 CALOHA:TS-2157 FMA:86936 cell striated muscle cell Muscle cell which has as its direct parts myofilaments organized into sarcomeres. GOC:tfm ISBN:0721662544 An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. BTO:0000751 CALOHA:TS-0549 FMA:62852 immune cell leucocyte white blood cell cell leukocyte true An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. GOC:add GOC:tfm ISBN:978-0-323-05290-0 The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. BTO:0001800 FMA:67765 RGC gangliocyte ganglion cell of retina cell retinal ganglion cell The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. GOC:dph A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord. SACMN cell spinal accessory motor neuron A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord. PMID:16267219 A round chondrocyte that first differentiates in the late embryonic growth plate of bone. cell periarticular chondrocyte A round chondrocyte that first differentiates in the late embryonic growth plate of bone. PMID:15951842 Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification). cell is hypertrophic pathological or normal? and can it be described using a pato term? hypertrophic chondrocyte Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification). GO_REF:0000034 PMID:15951842 A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate. cell columnar chondrocyte A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate. PMID:15951842 A neuron that laterally connects other neurons in the inner nuclear layer of the retina. BTO:0004120 horizontal cell cell retina horizontal cell A neuron that laterally connects other neurons in the inner nuclear layer of the retina. ISBN:0195088433 Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. FMA:83808 cardiocyte BTO:0001539 CALOHA:TS-0115 FMA:14067 cardiac muscle fiber cardiac myocyte cardiomyocyte heart muscle cell cell This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. cardiac muscle cell Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. GOC:mtg_cardiacconduct_nov11 GOC:tfm ISBN:0323052908 PMID:22426062 PMID:4711263 cardiac muscle fiber GO:0048739 A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance. cell blue chromatophore cyanophore A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance. SANBI:mhl A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer. cell retinal bipolar neuron A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer. PMID:14689473 A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors. cell ON-bipolar cell A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors. PMID:14689473 A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells hyperpolarize in response to light stimulation of their corresponding photoreceptors. cell OFF-bipolar cell A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells hyperpolarize in response to light stimulation of their corresponding photoreceptors. PMID:14689473 A bipolar neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer. FMA:67750 cell rod bipolar cell A bipolar neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer. GOC:tfm PMID:14689473 A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer. cell cone retinal bipolar cell A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer. PMID:14689473 An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities. DB1 cone bipolar cell cell type 1 cone bipolar cell (sensu Mus) An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities. PMID:14689473 An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1. FMB cone bipolar cell cell type 2 cone bipolar cell (sensu Mus) An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1. PMID:14689473 An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer. DB2 cone bipolar cell cell type 3 cone bipolar cell (sensu Mus) An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer. PMID:14689473 An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer. DB3 cone bipolar cell cell type 4 cone bipolar cell (sensu Mus) An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer. PMID:14689473 An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches. DB4 cone bipolar cell cell type 5 cone bipolar cell (sensu Mus) An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches. PMID:14689473 An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4. DB5 cone bipolar cell cell type 6 cone bipolar cell (sensu Mus) An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4. PMID:14689473 An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer. IMB cone bipolar cell cell type 7 cone bipolar cell (sensu Mus) An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer. PMID:14689473 An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer. DB6 cone bipolar cell cell type 8 cone bipolar cell (sensu Mus) An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer. PMID:14689473 An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer. BB cone bipolar cell cell type 9 cone bipolar cell (sensu Mus) An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer. PMID:14689473 A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates. cell Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. nucleated thrombocyte true A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates. GOC:add GOC:tfm PMID:16360205 A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. BTO:0001441 CALOHA:TS-0647 cell myeloid cell true A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. GOC:add A immature or mature cell in the lineage leading to and including erythrocytes. CL:0002156 CALOHA:TS-0290 FMA:62845 FMA:83516 erythropoietic cell cell Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. erythroid lineage cell A immature or mature cell in the lineage leading to and including erythrocytes. GOC:add GOC:tfm A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. BTO:0001571 CALOHA:TS-0289 FMA:83504 normoblast cell erythroblast true A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. GOC:add ISBN:0721601464 PMID:18174176 A cell of the monocyte, granulocyte, or mast cell lineage. cell myeloid leukocyte true A cell of the monocyte, granulocyte, or mast cell lineage. GOC:add Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive. polymorphonuclear leucocyte polymorphonuclear leukocyte BTO:0000129 CALOHA:TS-0073 FMA:62862 basophilic leucocyte basophilic leukocyte cell Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. basophil true Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive. GOC:add GOC:amm GOC:dsd GOC:tfm ISBN:0721601464 MESH:D001491 PMCID:PMC2626675 PMID:11927641 PMID:19741522 PMID:21236338 PMID:9933081 Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking. immature basophilic leucocyte immature basophilic leukocyte cell immature basophil true Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking. GOC:add ISBN:0721601464 A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive. FMA:84198 cell basophilic metamyelocyte true A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive. GOC:tfm ISBN:0721601464 PMID:18466030 A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil. cell band form basophil true A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil. GOC:add ISBN:0721601464 PMID:18466030 http://www.cap.org Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive. polymorphonuclear leucocyte polymorphonuclear leukocyte BTO:0000399 CALOHA:TS-0279 FMA:62861 eosinocyte eosinophilic granulocyte eosinophilic leucocyte eosinophilic leukocyte cell Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. eosinophil true Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive. GOC:add GOC:amm GOC:dsd GOC:tfm ISBN:0721601464 PMCID:PMC2626675 PMID:10914487 PMID:1662676 Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking. immature eosinocyte immature eosinophilic leucocyte immature eosinophilic leukocyte cell immature eosinophil true Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking. GOC:add ISBN:0721601464 A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative. cell eosinophilic metamyelocyte true A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative. GOC:add GOC:tfm ISBN:0721601464 PMID:19622087 A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil. cell band form eosinophil true A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil. GOC:add GOC:tfm ISBN:0721601464 PMID:19622087 http://www.cap.org Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. PMN poly polymorphonuclear leucocyte polymorphonuclear leukocyte polymorphonuclear neutrophil polynuclear neutrophilic leucocyte polynuclear neutrophilic leukocyte BTO:0000130 CALOHA:TS-0688 FMA:62860 neutrocyte neutrophil leucocyte neutrophil leukocyte neutrophilic leucocyte neutrophilic leukocyte cell neutrophil true Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. GOC:add GOC:amm GOC:tfm ISBN:0721601464 Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking. immatuer neutrophilic leukocyte immature neutrocyte immature neutrophil leucocyte immature neutrophil leukocyte immature neutrophilic leucocyte cell immature neutrophil true Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking. GOC:add ISBN:0721601464 A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling. mesangial cell cell mesangial phagocyte true A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling. GOC:add GOC:tfm ISBN:0702022918 ISBN:3540536663 PMID:1600140 PMID:16146841 A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts. cell Morphology: mononuclear, highly vesicular. mononuclear osteoclast true A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts. GOC:add GOC:tfm PMID:12713016 PMID:15055519 PMID:17380158 PMID:9415452 A specialized multinuclear osteoclast associated with the absorption and removal of bone. multinucleated osteoclast cell Morphology: multinucleated, highly vesicular. multinuclear osteoclast true A specialized multinuclear osteoclast associated with the absorption and removal of bone. GOC:add PMID:12713016 PMID:9415452 A specialized multinuclear osteoclast associated with the absorption and removal of cementum. multinucleated odontoclast cell Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth. multinuclear odontoclast true A specialized multinuclear osteoclast associated with the absorption and removal of cementum. GOC:add PMID:9415452 A specialized mononuclear osteoclast associated with the absorption and removal of cementum. cell Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth. mononuclear odontoclast true true A specialized mononuclear osteoclast associated with the absorption and removal of cementum. GOC:add PMID:9415452 A dendritic cell of the myeloid lineage. interdigitating cell veiled cell BTO:0004721 CD11c+CD123- DC mDC cell These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). myeloid dendritic cell true A dendritic cell of the myeloid lineage. GOC:add PMID:10449155 PMID:17332250 PMID:9521319 A phagocyte formed by the fusion of mononuclear phagocytes. cell multinucleated phagocyte true A phagocyte formed by the fusion of mononuclear phagocytes. GOC:add GOC:tfm A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection. BTO:0004625 DC2 IPC T-associated plasma cell interferon-producing cell lymphoid dendritic cell pDC plasmacytoid T cell plasmacytoid monocyte type 2 DC cell plasmacytoid dendritic cell true A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection. GOC:add GOC:dsd PMCID:PMC2118448 PMCID:PMC538703 PMID:15549123 PMID:17332250 PMID:17850486 PMID:20304825 A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen. mature B lymphocyte mature B-cell mature B-lymphocyte cell Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive. mature B cell true A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen. GOC:add GOC:dsd ISBN:0781735149 A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. BTO:0000392 FMA:70574 plasma B cell plasma B-cell plasmacyte plasmocyte cell effector B cell effector B-cell Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. plasma cell true A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. GOC:add GOC:dsd GO_REF:0000031 ISBN:0721601464 ISBN:0781735149 PMID:19447676 PMID:20081059 PMID:20839338 PMID:20951740 http://en.wikipedia.org/wiki/Plasma_cell A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative. memory B lymphocyte memory B-cell memory B-lymphocyte cell Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive. memory B cell true A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative. GOC:add GOC:dsd GOC:rhs GO_REF:0000031 ISBN:0781735149 PMID:20081059 PMID:20839338 http://en.wikipedia.org/wiki/Memory_B_cell A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery. naive B lymphocyte naive B-cell naive B-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. naive B cell true A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery. GOC:add GOC:dsd GOC:rhs GO_REF:0000031 ISBN:0781765196 PMID:19447676 PMID:20081059 PMID:20839338 PMID:20933013 PMID:22343568 A T cell that expresses an alpha-beta T cell receptor complex. alpha-beta T lymphocyte alpha-beta T-cell alpha-beta T-lymphocyte cell alpha-beta T cell true A T cell that expresses an alpha-beta T cell receptor complex. GOC:add GOC:tfm ISBN:0781735149 An alpha-beta T cell that has an immature phenotype and has not completed T cell selection. immature alpha-beta T lymphocyte immature alpha-beta T-cell immature alpha-beta T-lymphocyte cell immature alpha-beta T cell true An alpha-beta T cell that has an immature phenotype and has not completed T cell selection. GOC:add GOC:tfm ISBN:0781735149 A alpha-beta T cell that has a mature phenotype. mature alpha-beta T lymphocyte mature alpha-beta T-cell mature alpha-beta T-lymphocyte cell mature alpha-beta T cell true A alpha-beta T cell that has a mature phenotype. GOC:add GOC:tfm ISBN:0781735149 A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. Treg suppressor T cell suppressor T lymphocyte suppressor T-cell suppressor T-lymphocyte CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte CD4-positive, CD25-positive, alpha-beta regulatory T-cell CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. CD4-positive, CD25-positive, alpha-beta regulatory T cell true A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. GOC:add GOC:tfm ISBN:0781735149 PMID:19464985 PMID:22343568 Treg PMID:22343568 A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract. IEL intraepithelial lymphocyte CD4-positive, alpha-beta intraepithelial T lymphocyte CD4-positive, alpha-beta intraepithelial T-cell CD4-positive, alpha-beta intraepithelial T-lymphocyte cell CD4-positive, alpha-beta intraepithelial T cell true A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract. GOC:add GOC:tfm ISBN:0781735149 A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive. cytotoxic T cell cytotoxic T lymphocyte cytotoxic T-cell cytotoxic T-lymphocyte killer T cell killer T lymphocyte killer T-cell killer T-lymphocyte CALOHA:TS-0190 FMA:70573 CD8-positive, alpha-beta cytotoxic T lymphocyte CD8-positive, alpha-beta cytotoxic T-cell CD8-positive, alpha-beta cytotoxic T-lymphocyte cell Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. CD8-positive, alpha-beta cytotoxic T cell true A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive. GOC:add GOC:pam GOC:tfm GO_REF:0000031 ISBN:0781735149 A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. suppressor T cell suppressor T lymphocyte suppressor T-cell suppressor T-lymphocyte CD8+ T(reg) CD8+ Treg CD8+ regulatory T cell CD8-positive T(reg) CD8-positive Treg CD8-positive, alpha-beta Treg CD8-positive, alpha-beta regulatory T lymphocyte CD8-positive, alpha-beta regulatory T-cell CD8-positive, alpha-beta regulatory T-lymphocyte cell CD8-positive, alpha-beta regulatory T cell true A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. GOC:add GOC:tfm ISBN:0781735149 A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements. IEL intraepithelial lymphocyte CD8-positive, alpha-beta intraepithelial T lymphocyte CD8-positive, alpha-beta intraepithelial T-cell CD8-positive, alpha-beta intraepithelial T-lymphocyte cell CD8-alpha-beta-positive, alpha-beta intraepithelial T cell true A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements. GOC:add ISBN:0781735149 A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements. IEL intraepithelial lymphocyte alpha-beta intraepithelial T lymphocyte alpha-beta intraepithelial T-cell alpha-beta intraepithelial T-lymphocyte cell alpha-beta intraepithelial T cell true A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements. GOC:add GOC:tfm ISBN:0781735149 A T cell that expresses a gamma-delta T cell receptor complex. gamma-delta T lymphocyte gamma-delta T-cell gamma-delta T-lymphocyte gammadelta T cell cell gd T cell Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. gamma-delta T cell true A T cell that expresses a gamma-delta T cell receptor complex. GOC:add GOC:tfm ISBN:0781735149 A gamma-delta T cell that has an immature phenotype. immature gamma-delta T lymphocyte immature gamma-delta T-cell immature gamma-delta T-lymphocyte cell Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. immature gamma-delta T cell true A gamma-delta T cell that has an immature phenotype. GOC:add ISBN:0781735149 A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location. mature gamma-delta T lymphocyte mature gamma-delta T-cell mature gamma-delta T-lymphocyte cell mature gamma-delta T cell true A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location. GOC:add GOC:tfm ISBN:0781735149 A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses. IEL intraepithelial lymphocyte gamma-delta intraepithelial T lymphocyte gamma-delta intraepithelial T-cell gamma-delta intraepithelial T-lymphocyte cell gamma-delta intraepithelial T cell true A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses. GOC:add GOC:tfm ISBN:0781735149 A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive. IEL intraepithelial lymphocyte CD8-positive, gamma-delta intraepithelial T lymphocyte CD8-positive, gamma-delta intraepithelial T-cell CD8-positive, gamma-delta intraepithelial T-lymphocyte cell CD8-alpha alpha positive, gamma-delta intraepithelial T cell true A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive. GOC:add GOC:tfm ISBN:0781735149 A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative. IEL intraepithelial lymphocyte CD4-positive, gamma-delta intraepithelial T lymphocyte CD4-positive, gamma-delta intraepithelial T-cell CD4-positive, gamma-delta intraepithelial T-lymphocyte cell CD4-negative CD8-negative gamma-delta intraepithelial T cell true A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative. GOC:add GOC:tfm ISBN:0781735149 A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive. ISP T.ISP.th immature single positive T cell immature single positive T lymphocyte immature single positive T-lymphocyte cell Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. immature single positive thymocyte true A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 http://www.immgen.org/index_content.html A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive. DN2 alpha-beta immature T lymphocyte DN2 alpha-beta immature T-cell DN2 alpha-beta immature T-lymphocyte DN2 cell DN2 immature T cell TN2 cell TN2 thymocyte double negative 2 preT.DN2.Th cell Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. DN2 thymocyte A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain. early cortical thymocyte DN3 alpha-beta immature T lymphocyte DN3 alpha-beta immature T-cell DN3 alpha-beta immature T-lymphocyte DN3 cell DN3 immature T cell TN3 cell TN3 thymocyte double negative 3 preT.DN3.Th cell DN3 thymocyte A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive. early cortical thymocyte DN4 alpha-beta immature T lymphocyte DN4 alpha-beta immature T-lymphocyte DN4 cell DN4 immature T cell DN4 immature T-cell T.DN4.th double negative 4 cell Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. DN4 thymocyte A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors. late cortical thymocyte DP cell DP thymocyte double-positive, alpha-beta immature T lymphocyte cell Thymocytes of this stage are undergoing positive and negative selection. double-positive, alpha-beta thymocyte true A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative. CD4-positive, alpha-beta immature T lymphocyte CD4-positive, alpha-beta immature T-cell CD4-positive, alpha-beta immature T-lymphocyte SP CD4 cell cell CD4-positive, alpha-beta thymocyte true An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative. CD8-positive, alpha-beta immature T lymphocyte CD8-positive, alpha-beta immature T-cell CD8-positive, alpha-beta immature T-lymphocyte SP CD8 cell cell CD8-positive, alpha-beta immature T cell CD8-positive, alpha-beta thymocyte true An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive. BTO:0003435 memory T lymphocyte memory T-cell memory T-lymphocyte cell memory T cell true A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive. GOC:add GOC:pam GOC:tfm GO_REF:0000031 ISBN:0781735149 A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response. mature NK T lymphocyte mature NK T-cell mature NK T-lymphocyte mature NKT cell mature natural killer T cell mature natural killer T lymphocyte mature natural killer T-cell mature natural killer T-lymphocyte cell mature NK T cell true A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response. GOC:add ISBN:0781735149 A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. suppressor T cell suppressor T lymphocyte suppressor T-cell suppressor T-lymphocyte BTO:0004520 FMA:84070 regulatory T lymphocyte regulatory T-cell regulatory T-lymphocyte cell This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. regulatory T cell true A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. GOC:add GO_REF:0000031 An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation. immature B lymphocyte immature B-cell immature B-lymphocyte newly formed B cell cell Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive. immature B cell An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation. GOC:add GOC:dsd GOC:rhs GOC:tfm GO_REF:0000031 ISBN:0781735149 PMID:20081059 PMID:20839338 newly formed B cell ISBN:781735149 A precursor B cell is a B cell with the phenotype CD10-positive. BTO:0001133 CALOHA:TS-0819 cell pre-B cell precursor B cell true A precursor B cell is a B cell with the phenotype CD10-positive. GOC:rhs GOC:tfm GO_REF:0000031 An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen. transitional B cell transitional stage B lymphocyte transitional stage B-cell transitional stage B-lymphocyte T1 B cell T2 B cell T3 B cell cell This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'. transitional stage B cell true An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen. GOC:add GO_REF:0000031 ISBN:0781735149 PMID:12810111 PMID:22343568 transitional B cell PMID:22343568 A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive. B-1 B lymphocyte B-1 B-cell B-1 B-lymphocyte B-1 cell B1 B cell B1 B lymphocyte B1 B-cell B1 B-lymphocyte B1 cell cell There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low. B-1 B cell true A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive. GOC:add GOC:dsd GO_REF:0000031 PMID:11861604 PMID:20933013 PMID:21220451 http://en.wikipedia.org/wiki/B-1_cell A B-1 B cell that has the phenotype CD5-positive. B-1a B lymphocyte B-1a B-cell B-1a B-lymphocyte B1a B cell B1a B lymphocyte B1a B-cell B1a B-lymphocyte B1a cell CD5(+) B1 cell CD5+ B1 cell CD5-positive B1 cell cell B-1a B cell true A B-1 B cell that has the phenotype CD5-positive. GOC:add PMID:11861604 A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell. B-1b B lymphocyte B-1b B-cell B-1b B-lymphocyte B1b B cell B1b B lymphocyte B1b B-cell B1b B-lymphocyte B1b cell cell B-1b B cell true A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell. GOC:add PMID:11861604 A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative. B-2 B lymphocyte B-2 B-cell B-2 B-lymphocyte B2 B cell B2 B lymphocyte B2 B-cell B2 B-lymphocyte B2 cell cell B-0 B cell B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive. B-2 B cell true A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative. GOC:add GOC:dsd GOC:tfm ISBN:0781735149 PMID:11861604 PMID:20933013 A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR). immature NK cell cell p-NK In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. immature natural killer cell true A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR). GOC:add GO_REF:0000031 ISBN:0781735149 PMID:12457618 p-NK PMID:12457618 A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules. LAK cell lymphokine activated killer cell mature NK cell cell mature natural killer cell A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules. GOC:add GO_REF:0000031 ISBN:0781735149 PMID:14685782 LAK cell PMID:14685782 lymphokine activated killer cell PMID:14685782 A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative. NKP natural killer cell progenitor pro-natural killer cell cell null cell preNK cell Most markers only described for human pro NK cells. pro-NK cell true A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative. GOC:add GOC:pam GO_REF:0000031 PMID:11532393 PMID:12457618 PMID:15032583 PMID:15766674 NKP PMID:12457618 PMID:15032583 PMID:15766674 null cell PMID:11532393 preNK cell PMID:11532393 A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. pre-pro B cell BTO:0003104 pro-B lymphocyte pro-B-cell pro-B-lymphocyte progenitor B cell progenitor B lymphocyte progenitor B-cell progenitor B-lymphocyte cell pre-B cell (Philadelphia nomenclature) Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. pro-B cell true A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. GOC:add GOC:dsd ISBN:0781735149 PMID:12633665 PMID:16551251 PMID:18432934 pre-pro B cell PMID:17582343 pre-B cell (Philadelphia nomenclature) PMID:11244048 A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage. pro-T lymphocyte progenitor T cell DN1 cell DN1 thymocyte TN1 cell cell pro-T cell true A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage. GOC:add ISBN:0781735149 A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates. cell Note that this is a non-mammalian cell type. thromboblast true A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates. GOC:add GOC:tfm PMID:7758949 A myeloblast committed to the basophil lineage. cell basophilic myeloblast true A myeloblast committed to the basophil lineage. GOC:add ISBN:0721601464 A promyelocyte committed to the basophil lineage. FMA:84208 cell basophilic promyelocyte true A promyelocyte committed to the basophil lineage. GOC:add ISBN:0721601464 A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative. MCP cell CFU-MC CFU-Mast colony forming unit mast cell MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa. mast cell progenitor true A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative. GOC:add GOC:dsd PMCID:PMC1183570 PMCID:PMC1312421 PMID:8629001 PMID:9354811 http://www.copewithcytokines.de A myeloblast committed to the eosinophil lineage. cell eosinophilic myeloblast true A myeloblast committed to the eosinophil lineage. GOC:add ISBN:0721601464 A promyelocyte committed to the eosinophil lineage. FMA:84199 cell eosinophilic promyelocyte true A promyelocyte committed to the eosinophil lineage. GOC:add ISBN:0721601464 A progenitor cell of the neutrophil lineage. cell neutrophil stem cell neutrophil progenitor cell true A progenitor cell of the neutrophil lineage. GOC:add GOC:tfm ISBN:0721601464 The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow. BTO:0000187 FMA:83524 cell myeloblast true The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow. GOC:add ISBN:0721601464 http://en.wikipedia.org/wiki/Myeloblast http://www.cap.org A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative. CALOHA:TS-0825 FMA:83530 cell promyelocyte A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative. GOC:add GOC:amm GOC:tfm ISBN:0721601464 http://www.cap.org A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. BTO:0000725 CALOHA:TS-0448 MPP hemopoietic progenitor cell cell Markers differ between mouse and human. hematopoietic multipotent progenitor cell A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. GOC:add GOC:tfm PMID:19022770 A progenitor cell restricted to the lymphoid lineage. lymphoid progenitor cell BTO:0004731 CALOHA:TS-2025 FMA:70338 cell Note that this is a class of cell types, not an identified single cell type. lymphoid lineage restricted progenitor cell true A progenitor cell restricted to the lymphoid lineage. GOC:add GOC:tfm A progenitor cell restricted to the myeloid lineage. myeloid progenitor cell BTO:0004730 CALOHA:TS-2099 FMA:70339 cell Note that this is a class of cell types, not an identified single cell type. myeloid lineage restricted progenitor cell true A progenitor cell restricted to the myeloid lineage. GOC:add GOC:tfm PMID:19022770 An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low. immature myeloid dendritic cell cell immature conventional dendritic cell true An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low. GOC:add GOC:tfm PMID:9521319 A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node. mature dendritic cell FMA:83038 mature myeloid dendritic cell cell mature conventional dendritic cell true A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node. GOC:add GOC:tfm PMID:9521319 mature dendritic cell GOC:add A leukocyte with a single non-segmented nucleus in the mature form. BTO:0000878 CALOHA:TS-0768 FMA:86713 mononuclear leukocyte peripheral blood mononuclear cell cell mononuclear cell A leukocyte with a single non-segmented nucleus in the mature form. GOC:add A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative. Fo B cell Fo B-cell follicular B lymphocyte follicular B-cell follicular B-lymphocyte cell Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. follicular B cell A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative. GOC:add GOC:dsd ISBN:0781735149 PMCID:PMC2193793 PMID:20933013 http://en.wikipedia.org/wiki/Follicular_B_Cells A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation. GC B cell GC B lymphocyte GC B-cell GC B-lymphocyte germinal center B lymphocyte germinal center B-cell germinal center B-lymphocyte cell Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. germinal center B cell true A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation. GOC:add GOC:dsd GOC:tfm ISBN:0781735149 PMID:19447676 PMID:20933013 A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high. MZ B cell MZ B lymphocyte MZ B-cell MZ B-lymphocyte marginal zone B lymphocyte marginal zone B-cell marginal zone B-lymphocyte cell MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive. marginal zone B cell true A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high. GOC:add GOC:dsd ISBN:0781735149 PMID:10933592 PMID:20933013 http://en.wikipedia.org/wiki/Marginal-zone_B_cell An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings. cell vestibular dark cell An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings. PMID:11223304 An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob. ciliated olfactory sensory neuron ciliated sensory neuron cell ciliated olfactory receptor neuron An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob. PMID:16841163 An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli. microvillous olfactory sensory neuron cell microvillous sensory neuron microvillous olfactory receptor neuron An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli. PMID:16841163 An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli. crypt cell crypt olfactory sensory neuron crypt sensory neuron cell crypt olfactory receptor neuron An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli. PMID:16841163 A neuron that releases serotonin as a neurotransmitter. CL:0000403 FBbt:00005133 WBbt:0006837 5-HT neuron 5-hydroxytryptamine neuron cell serotinergic neuron serotonergic neuron A neuron that releases serotonin as a neurotransmitter. SANBI:mhl Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded. cell neuromast mantle cell Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded. ISBN:0125296509 Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells. cell neuromast support cell Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells. ISBN:0125296509 Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons. FMA:62302 olfactory sustentacular cell supporting cell of olfactory epithelium sustentaculocyte of olfactory epithelium cell olfactory epithelial support cell Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons. GOC:tfm ISBN:0517223651 SANBI:mhl Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts. cell interneuromast cell Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts. SANBI:mhl Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system. hair cell BTO:0004744 cell sensory hair cell Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system. SANBI:mhl Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. cell neuromast hair cell Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. SANBI:mhl A skeletal muscle myoblast that differentiates into slow muscle fibers. cell slow muscle myoblast A skeletal muscle myoblast that differentiates into slow muscle fibers. SANBI:mhl A skeletal muscle myoblast that differentiates into fast muscle fibers. cell fast muscle myoblast A skeletal muscle myoblast that differentiates into fast muscle fibers. SANBI:mhl A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes. inflammatory monocyte cell Markers: CCR2+CXCCR1<low> (human, mouse, rat). classical monocyte true A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes. GOC:add GO_REF:0000031 PMID:16322748 PMID:18303997 PMID:20628149 PMID:20870168 A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive. FMA:84643 FMA:84645 free macrophage wandering histiocyte cell Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). elicited macrophage true A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive. GOC:add GOC:ana GOC:tfm GO_REF:0000031 PMID:15771589 A macrophage that suppresses immune responses. cell Markers: May express: IL10, TGFbeta. suppressor macrophage true A macrophage that suppresses immune responses. GOC:add GOC:tfm PMID:20402419 An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity. classically activated macrophage cell M1 macrophage Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response). inflammatory macrophage true An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity. GOC:ana GO_REF:0000031 PMID:19132917 A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. FMA:84642 FMA:84644 fixed macrophage resting histiocyte cell tissue-resident macrophage true A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. GOC:ana GO_REF:0000031 PMID:19770654 A gut-associated lymphoid tissue macrophage found in lamina propria of the gut. cell gastrointestinal tract (lamina propria) macrophage true A gut-associated lymphoid tissue macrophage found in lamina propria of the gut. GOC:ana GOC:tfm GO_REF:0000031 A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes. cell Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation. thymic macrophage true A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes. GOC:ana GOC:tfm GO_REF:0000031 PMID:9048205 A tissue-resident macrophage found in a secondary lymphoid organ. cell secondary lymphoid organ macrophage A tissue-resident macrophage found in a secondary lymphoid organ. GOC:ana GOC:tfm GO_REF:0000031 A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high. MF.LN cell Marker was observed on rat cells. lymph node macrophage true A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high. GOC:ana GOC:tfm GO_REF:0000031 PMID:11971865 A gut-associated lymphoid tissue macrophage found in tonsils. cell tonsillar macrophage A gut-associated lymphoid tissue macrophage found in tonsils. GOC:ana GO_REF:0000031 PMID:16048540 A gut-associated lymphoid tissue macrophage found in the Peyer's patches. cell Peyer's patch macrophage true A gut-associated lymphoid tissue macrophage found in the Peyer's patches. GOC:ana GOC:tfm GO_REF:0000031 A secondary lymphoid organ macrophage found in the spleen. FMA:83026 cell Role or process: immune, clearance of apoptotic and senescent cells. splenic macrophage true A secondary lymphoid organ macrophage found in the spleen. GO_REF:0000031 PMID:15771589 PMID:16322748 A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive. cell Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. splenic marginal zone macrophage true A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive. GOC:ana GO_REF:0000031 PMID:16861066 A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive. cell Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+. splenic metallophillic macrophage true A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive. GOC:ana GO_REF:0000031 PMID:20018690 A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low. cell Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes. splenic red pulp macrophage true A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low. GOC:ana GO_REF:0000031 PMID:19644016 A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair. patrolling monocyte resident monocyte cell Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-. non-classical monocyte true A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair. GOC:add GO_REF:0000031 PMID:16322748 PMID:18303997 PMID:20628149 PMID:20870168 A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive. cell Markers: Mouse: F4/80-, CD68+, macrosialin+. splenic white pulp macrophage true A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive. GOC:ana GO_REF:0000031 PMID:11207597 A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive. cell splenic tingible body macrophage true A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive. GOC:ana GOC:tfm GO_REF:0000031 PMID:19631584 A tissue-resident macrophage found in the central nervous system. CNS macrophage cell central nervous system macrophage true A tissue-resident macrophage found in the central nervous system. GO_REF:0000031 PMID:16322748 A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors. cell meningeal macrophage true A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors. GOC:ana GO_REF:0000031 PMID:11591794 A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors. cell choroid-plexus macrophage true A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors. GOC:ana GO_REF:0000031 PMID:9550136 A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+. cell Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. perivascular macrophage true A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+. GOC:tfm GO_REF:0000031 PMID:16507898 A thymic macrophage found in the thymic medulla. cell thymic medullary macrophage true A thymic macrophage found in the thymic medulla. GOC:ana GO_REF:0000031 PMID:9048205 A thymic macrophage found in the thymic cortex. cell thymic cortical macrophage true A thymic macrophage found in the thymic cortex. GOC:ana GOC:tfm GO_REF:0000031 PMID:9048205 A tissue-resident macrophage found in the mucosa associated lymphoid tissue. cell mucosa-associated lymphoid tissue macrophage true A tissue-resident macrophage found in the mucosa associated lymphoid tissue. GOC:ana GOC:tfm GO_REF:0000031 PMID:19906191 A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut. cell gut-associated lymphoid tissue macrophage true A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut. GOC:ana GO_REF:0000031 PMID:19906191 A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues. cell nasal and broncial associated lymphoid tissue macrophage true A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues. GOC:ana GO_REF:0000031 PMID:16048540 A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive. cell lymph node subcapsular sinus macrophage true A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive. GOC:tfm GO_REF:0000031 PMID:14668803 PMID:17934446 PMID:20228797 A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers. cell lymph node tingible body macrophage true A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers. GOC:ana GOC:tfm GO_REF:0000031 PMID:19631584 An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive. cell Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis. myeloid suppressor cell true An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive. GOC:add GOC:ana GO_REF:0000031 PMID:16168663 PMID:17016554 PMID:17016559 An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling. cell M2 macrophage Role or process: tissue remodeling. alternatively activated macrophage true An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling. GOC:ana GOC:tfm GO_REF:0000031 PMID:20510870 A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions. BTO:0003872 FMA:83586 cell foam cell A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions. GOC:add A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions. cell smooth muscle cell derived foam cell A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions. GOC:add An immature T cell located in the thymus. immature T cell immature T lymphocyte immature T-cell immature T-lymphocyte BTO:0001372 CALOHA:TS-1042 FMA:72202 XAO:0003159 thymic lymphocyte cell thymocyte true An immature T cell located in the thymus. GOC:add GOC:tfm GO_REF:0000031 PMID:12415312 A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative. DN1 thymic pro-T lymphocyte DN1 thymic pro-T-cell DN1 thymic pro-T-lymphocyte DN1 thymic progenitor T cell DN1 thymocyte double negative 1 preT.DN1.Th cell DN1 thymic pro-T cell true A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative. GOC:add GOC:tfm GO_REF:0000031 An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low. naive CD4+ T cell T.4Nve.Sp Th0 naive thymus-derived CD4-positive, alpha-beta T lymphocyte naive thymus-derived CD4-positive, alpha-beta T-cell naive thymus-derived CD4-positive, alpha-beta T-lymphocyte cell These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells. naive thymus-derived CD4-positive, alpha-beta T cell true An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low. GOC:add GOC:tfm GO_REF:0000031 PMID:19100699 PMID:22343568 http://www.immgen.org/index_content.html naive CD4+ T cell PMID:22343568 Th0 GOC:tfm A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive. activated CD4-positive, alpha-beta T lymphocyte activated CD4-positive, alpha-beta T-cell activated CD4-positive, alpha-beta T-lymphocyte cell activated CD4-positive, alpha-beta T cell true A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive. GOC:add GOC:pam GO_REF:0000031 CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high. CD4-positive, alpha-beta memory T lymphocyte CD4-positive, alpha-beta memory T-cell CD4-positive, alpha-beta memory T-lymphocyte cell T4.Mem.Sp CD4-positive, alpha-beta memory T cell true CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 http://www.immgen.org/index_content.html Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. naive T lymphocyte naive T-cell naive T-lymphocyte cell naive T cell true Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19100699 CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17. IL-17-producing CD4+ T helper T helper cells type 17 T(H)-17 cell Th17 CD4+ T cell Th17 T cell Th17 T lymphocyte Th17 T-cell Th17 T-lymphocyte Th17 cell helper T cell type 17 cell This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells. T-helper 17 cell true CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17. GOC:add GOC:pam GO_REF:0000031 PMID:20303875 PMID:20969597 PMID:22343568 Th17 CD4+ T cell PMID:22343568 A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. naive CD8+ T cell naive thymus-dervied CD8-positive, alpha-beta T lymphocyte naive thymus-dervied CD8-positive, alpha-beta T-cell naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte T.8Nve.Sp cell This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells. naive thymus-derived CD8-positive, alpha-beta T cell true A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. GOC:add GOC:tfm GO_REF:0000031 ISBN:0781735149 PMID:22343568 http://www.immgen.org/index_content.html naive CD8+ T cell PMID:22343568 CD4-positive alpha-beta T cell with regulatory function that produces IL-10. T-regulatory T cell type 1 Tr1 T cell Tr1 T lymphocyte Tr1 T-cell Tr1 T-lymphocyte cell These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.) Tr1 cell CD4-positive alpha-beta T cell with regulatory function that produces IL-10. GOC:add GOC:pam GO_REF:0000031 PMID:16903904 CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function. iTreg induced Treg induced regulatory T cell induced regulatory T lymphocyte induced regulatory T-cell induced regulatory T-lymphocyte cell aTreg adaptive Treg induced T-regulatory cell true CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19464985 CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function. nTreg natural Treg natural regulatory T cell natural regulatory T lymphocyte natural regulatory T-cell natural regulatory T-lymphocyte cell natural T-regulatory cell true CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19464985 CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. central memory CD4+ T cell central CD4-positive, alpha-beta memory T cell central CD4-positive, alpha-beta memory T lymphocyte central CD4-positive, alpha-beta memory T-cell central CD4-positive, alpha-beta memory T-lymphocyte central memory CD4-positive, alpha-beta T lymphocyte central memory CD4-positive, alpha-beta T-cell central memory CD4-positive, alpha-beta T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells. central memory CD4-positive, alpha-beta T cell true CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. GOC:add GOC:pam GO_REF:0000031 PMID:22343568 central memory CD4+ T cell PMID:22343568 CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. effector memory CD4+ T cell effector CD4-positive, alpha-beta memory T cell effector CD4-positive, alpha-beta memory T lymphocyte effector CD4-positive, alpha-beta memory T-cell effector CD4-positive, alpha-beta memory T-lymphocyte effector memory CD4-positive, alpha-beta T lymphocyte effector memory CD4-positive, alpha-beta T-cell effector memory CD4-positive, alpha-beta T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells. effector memory CD4-positive, alpha-beta T cell true CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:22343568 effector memory CD4+ T cell PMID:22343568 A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative. activated CD8-positive, alpha-beta T lymphocyte activated CD8-positive, alpha-beta T-cell activated CD8-positive, alpha-beta T-lymphocyte cell activated CD8-positive, alpha-beta T cell true A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative. GOC:add GOC:pam GOC:tfm GO_REF:0000031 CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. central memory CD8+ T cell central CD8-positive, alpha-beta memory T cell central CD8-positive, alpha-beta memory T lymphocyte central CD8-positive, alpha-beta memory T-cell central CD8-positive, alpha-beta memory T-lymphocyte central memory CD8-positive, alpha-beta T lymphocyte central memory CD8-positive, alpha-beta T-cell central memory CD8-positive, alpha-beta T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells. central memory CD8-positive, alpha-beta T cell true CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:20146720 PMID:22343568 central memory CD8+ T cell PMID:22343568 A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines. CD8-positive, alpha-beta cytokine secreting effector T lymphocyte CD8-positive, alpha-beta cytokine secreting effector T-cell CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte cell CD8-positive, alpha-beta cytokine secreting effector T cell true A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:20146720 A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high. CD8-positive, alpha-beta memory T lymphocyte CD8-positive, alpha-beta memory T-cell CD8-positive, alpha-beta memory T-lymphocyte T.8Mem.Sp cell CD8-positive, alpha-beta memory T cell true A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high. GOC:tfm GO_REF:0000031 PMID:20146720 A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive. BTO:0000289 CALOHA:TS-0190 FMA:70573 cytotoxic T lymphocyte cytotoxic T-cell cytotoxic T-lymphocyte cell cytotoxic T cell true A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:18395547 A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response. effector T lymphocyte effector T-cell effector T-lymphocyte cell effector T cell true A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response. GOC:PAM-ADD GOC:tfm ISBN:0877799148 PMID:18395547 A effector T cell that provides help in the form of secreted cytokines to other immune cells. BTO:0002417 T-helper cell helper T lymphocyte helper T-cell helper T-lymphocyte cell helper T cell true A effector T cell that provides help in the form of secreted cytokines to other immune cells. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:18395547 CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. effector memory CD8+ T cell effector CD8-positive, alpha-beta memory T cell effector CD8-positive, alpha-beta memory T lymphocyte effector CD8-positive, alpha-beta memory T-cell effector CD8-positive, alpha-beta memory T-lymphocyte effector memory CD8-positive, alpha-beta T lymphocyte effector memory CD8-positive, alpha-beta T-cell effector memory CD8-positive, alpha-beta T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells. effector memory CD8-positive, alpha-beta T cell true CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. GOC:add GOC:pam GO_REF:0000031 PMID:20146720 PMID:22343568 effector memory CD8+ T cell PMID:22343568 An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers. immature NK T lymphocyte immature NK T-cell immature NK T-lymphocyte immature NKT cell cell immature NK T cell true An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17589542 PMID:19169262 An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative. CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte cell CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell true An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative. GOC:add GOC:pam GO_REF:0000031 PMID:11685222 A mature gamma-delta T cell located in the epidermis that regulates wound healing. DETC dendritic epidermal T lymphocyte dendritic epidermal T-cell dendritic epidermal T-lymphocyte cell In mice, DETC have an invariant T cell receptor. dendritic epidermal T cell true A mature gamma-delta T cell located in the epidermis that regulates wound healing. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:11976459 A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma. BTO:0004793 BTO:0004888 FMA:84793 T-cytotoxic T cell type 1 Tc1 CD8+ T cell Tc1 T cell Tc1 T lymphocyte Tc1 T-cell Tc1 T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells. Tc1 cell true A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma. GOC:add GOC:pam GO_REF:0000031 PMID:22343568 PMID:9914231 Tc1 CD8+ T cell PMID:22343568 A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4. BTO:0004794 FMA:84794 T-cytotoxic T cell type 2 Tc2 T cell Tc2 T lymphocyte Tc2 T-cell Tc2 T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell. Tc2 cell true A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:9914231 A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function. CD8+CD25+ T cell CD8+CD25+ T lymphocyte CD8+CD25+ T(reg) CD8+CD25+ T-cell CD8+CD25+ T-lymphocyte CD8+CD25+ Treg CD8-positive, CD25-positive Treg CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte CD8-positive, CD25-positive, alpha-beta regulatory T-cell CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte cell CD8-positive, CD25-positive, alpha-beta regulatory T cell true A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19118505 CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive. CD8+CD28- T cell CD8+CD28- T lymphocyte CD8+CD28- T(reg) CD8+CD28- T-cell CD8+CD28- T-lymphocyte CD8+CD28- Treg CD8-positive, CD28-negative T(reg) CD8-positive, CD28-negative Treg CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte CD8-positive, CD28-negative, alpha-beta regulatory T-cell CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte cell CD8-positive, CD28-negative, alpha-beta regulatory T cell true CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19118505 An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d. classical NK T cell type I NK T lymphocyte type I NK T-cell type I NK T-lymphocyte type I NKT cell cell invariant NK T cell In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24. type I NK T cell true An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:15039760 An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d. type II NK T lymphocyte type II NK T-cell type II NK T-lymphocyte type II NKT cell cell type II NK T cell true An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:15039760 A type I NK T cell that has the phenotype CD4-positive. CD4-positive type I NK T lymphocyte CD4-positive type I NK T-cell CD4-positive type I NK T-lymphocyte CD4-positive type I NKT cell NKT.4+.SP cell CD4-positive type I NK T cell true A type I NK T cell that has the phenotype CD4-positive. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17303398 A type I NK T cell that has the phenotype CD4-negative and CD8-negative. CD4-negative, CD8-negative type I NK T lymphocyte CD4-negative, CD8-negative type I NK T-cell CD4-negative, CD8-negative type I NK T-lymphocyte CD4-negative, CD8-negative type I NKT cell NKT.4-.Sp cell CD4-negative, CD8-negative type I NK T cell true A type I NK T cell that has the phenotype CD4-negative and CD8-negative. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:18997862 A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers. activated CD4-positive type I NK T lymphocyte activated CD4-positive type I NK T-cell activated CD4-positive type I NK T-lymphocyte activated CD4-positive type I NKT cell cell activated CD4-positive type I NK T cell A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17303398 A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses. CD4-positive type I NK T cell secreting IFN-gamma CD4-positive type I NK T lymphocyte secreting interferon-gamma CD4-positive type I NK T-cell secreting interferon-gamma CD4-positive type I NK T-lymphocyte secreting interferon-gamma CD4-positive type I NKT cell secreting interferon-gamma cell CD4-positive type I NK T cell secreting interferon-gamma A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17303398 A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses. CD4-positive type I NK T cell secreting IL-4 CD4-positive type I NK T lymphocyte secreting interleukin-4 CD4-positive type I NK T-cell secreting interleukin-4 CD4-positive type I NK T-lymphocyte secreting interleukin-4 CD4-positive type I NKT cell secreting interleukin-4 cell CD4-positive type I NK T cell secreting interleukin-4 A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses. GOC:add GOC:pam GOC:tfm GO_REF:0000031 A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers. activated CD4-negative, CD8-negative type I NK T lymphocyte activated CD4-negative, CD8-negative type I NK T-cell activated CD4-negative, CD8-negative type I NK T-lymphocyte activated CD4-negative, CD8-negative type I NKT cell cell activated CD4-negative, CD8-negative type I NK T cell A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17303398 A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses. CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma cell CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17303398 A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses. CD4-negative, CD8-negative type I NK T cell secreting IL-4 CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4 CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4 CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4 CD4-negative, CD8-negative type I NKT cell secreting interleukin-4 cell CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17303398 A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers. activated type II NK T lymphocyte activated type II NK T-cell activated type II NK T-lymphocyte activated type II NKT cell cell activated type II NK T cell true A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17964217 A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers. type II NK T cell secreting IFN-gamma type II NK T lymphocyte secreting interferon-gamma type II NK T-cell secreting interferon-gamma type II NK T-lymphocyte secreting interferon-gamma type II NKT cell secreting interferon-gamma cell type II NK T cell secreting interferon-gamma true A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers. GOC:add GOC:pam GO_REF:0000031 PMID:17964217 A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers. type II NK T cell secreting IL-4 type II NK T lymphocyte secreting interleukin-4 type II NK T-cell secreting interleukin-4 type II NK T-lymphocyte secreting interleukin-4 type II NKT cell secreting interleukin-4 cell type II NK T cell secreting interleukin-4 true A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:17964217 A CD4-positive, alpha-beta T cell that has cytotoxic function. CD4-positive, alpha-beta cytotoxic T lymphocyte CD4-positive, alpha-beta cytotoxic T-cell CD4-positive, alpha-beta cytotoxic T-lymphocyte cell CD4-positive, alpha-beta cytotoxic T cell true A CD4-positive, alpha-beta T cell that has cytotoxic function. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:18440213 A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract. CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte cell CD4-negative, CD8-negative, alpha-beta intraepithelial T cell true A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract. GOC:add GOC:pam GO_REF:0000031 PMID:11685222 A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative. ELP LMPP lymphoid-primed multipotent progenitor cell GMLP Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. early lymphoid progenitor true A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative. GOC:add GOC:dsd GOC:pam GOC:tfm GO_REF:0000031 PMID:19022770 GMLP PMID:18371378 Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins. pre-NK cell cell These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. pre-natural killer cell true Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins. GOC:add GOC:dsd GOC:pam GOC:tfm GO_REF:0000031 PMID:16551251 PMID:17100874 NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic. CD16-CD56bright NK cell CD16-negative, CD56-bright NK cell CD56-bright cytokine secreting NK cell CD56-bright cytokine secreting natural killer cell cell This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types. CD16-negative, CD56-bright natural killer cell true NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19796267 PMID:22343568 CD16-CD56bright NK cell PMID:22343568 A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production. CD16+CD56+ NK cell CD16-positive, CD56-dim NK cell CD16-positive, CD56-low NK cell CD16-positive, CD56-low natural killer cell CD16-positive, CD56-positive NK cell CD16-positive, CD56-positive natural killer cell cytotoxic CD56-dim NK cell cytotoxic CD56-dim natural killer cell cell This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types. CD16-positive, CD56-dim natural killer cell true A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production. GOC:add GOC:pam GO_REF:0000031 PMID:19796267 PMID:22343568 CD16+CD56+ NK cell PMID:22343568 An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule. mucosal invariant T lymphocyte mucosal invariant T-cell mucosal invariant T-lymphocyte cell mucosal invariant T cell true An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19416870 A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative. cell In the mouse this cell expresses CD8-alpha-alpha. thymic conventional dendritic cell true A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative. GOC:add GOC:pam GO_REF:0000031 PMID:19273629 A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive. cell thymic plasmacytoid dendritic cell true A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive. GOC:add GOC:pam GOC:tfm GO_REF:0000031 PMID:19941119 A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma. B effector 1 cell cell B effector cell type 1 Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive. Be1 Cell true A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma. GOC:dsd GOC:msz GOC:tfm GO_REF:0000031 PMID:11101868 PMID:20224569 B effector 1 cell PMID:11101868 PMID:20224569 A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6. B effector 2 cell cell B effector cell type 2 Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive. Be2 cell true A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6. GOC:dsd GOC:msz GOC:tfm GO_REF:0000031 PMID:11101868 PMID:20224569 B effector 2 cell PMID:11101868 PMID:20224569 A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex. cell Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). lymphocyte of B lineage true A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex. GOC:add GOC:rhs GOC:tfm GO_REF:0000031 ISBN:0781735149 A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin. cell antibody secreting cell true A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin. GOC:add GOC:tfm GO_REF:0000031 ISBN:0721601464 ISBN:0781735149 A long lived plasma cell that secretes IgE. cell IgE plasma cell true A long lived plasma cell that secretes IgE. GOC:msz GO_REF:0000031 ISBN:781735149 A class switched memory B cell that expresses IgE on the cell surface. IgE memory B lymphocyte IgE memory B-cell IgE memory B-lymphocyte memory IgE B cell memory IgE B lymphocyte memory IgE B-cell memory IgE B-lymphocyte cell IgE memory B cell true A class switched memory B cell that expresses IgE on the cell surface. GOC:rhs GO_REF:0000031 ISBN:0781765196 A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult. cell IgD plasmablast true A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult. GOC:msz GO_REF:0000031 A plasmablast that secretes IgE. cell IgE plasmablast true A plasmablast that secretes IgE. GOC:msz GO_REF:0000031 A short lived plasma cell that secretes IgE. cell IgE short lived plasma cell true A short lived plasma cell that secretes IgE. GOC:msz GO_REF:0000031 ISBN:781735149 An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface. cell preBCR-positive large pre-B-II cell true An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface. GOC:rhs GOC:tfm GO_REF:0000031 PMID:9785673 A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes. cell preBCR-negative large pre-B-II cell true A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes. GOC:rhs GOC:tfm GO_REF:0000031 PMID:9785673 A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes. small pre-BII cell cell Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. small pre-B-II cell true A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes. GOC:dsd GOC:rhs GOC:tfm GO_REF:0000031 PMID:16551251 PMID:18432934 PMID:9785673 A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain. BTO:0001133 CALOHA:TS-0819 pre-B-lymphocyte pre-BII cell cell pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive. pre-B-II cell true A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain. GOC:dsd GOC:rhs GOC:tfm GO_REF:0000031 PMID:9785673 A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein. pre-BI cell cell pro-B cell (Philadelphia nomenclature) Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive. pre-B-I cell true A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein. GOC:dsd GOC:rhs GOC:tfm GO_REF:0000031 PMID:16551251 PMID:18432934 PMID:20839338 PMID:9785673 pro-B cell (Philadelphia nomenclature) PMID:11244048 A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative. large pre-B cell large pre-BII cell cell Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. large pre-B-II cell true A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative. GOC:dsd GOC:rhs GO_REF:0000031 PMID:16551251 PMID:18432934 PMID:9785673 large pre-B cell PMID:11244048 A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative. T1 B lymphocyte T1 B-cell T1 B-lymphocyte transitional stage 1 B cell cell T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. T1 B cell true A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative. GOC:dsd GOC:msz GOC:tfm GO_REF:0000031 PMCID:PMC2193793 PMID:12810111 A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive. T2 B lymphocyte T2 B-cell T2 B-lymphocyte transitional stage 2 B cell cell T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. T2 B cell true A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive. GOC:dsd GOC:msz GOC:tfm GO_REF:0000031 PMCID:PMC2193793 PMID:12810111 A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM). An1 B cell T3 B lymphocyte T3 B-cell T3 B-lymphocyte transitional stage 3 B cell cell T3 B cell true A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM). GOC:msz GOC:tfm GO_REF:0000031 PMID:12810111 PMID:17174121 http://www.immgen.org/index_content.html An1 B cell PMID:17174121 A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells. Bm1 B lymphocyte Bm1 B-cell Bm1 B-lymphocyte cell These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. Bm1 B cell true A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells. GOC:dsd GOC:msz GO_REF:0000031 PMID:17992590 PMID:18432934 PMID:8006591 A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells. Bm2 B lymphocyte Bm2 B-cell Bm2 B-lymphocyte cell These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. Bm2 B cell true A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells. GOC:dsd GOC:msz GO_REF:0000031 PMID:17992590 PMID:18432934 PMID:8006591 A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive. Bm3-delta B lymphocyte Bm3-delta B-cell Bm3-delta B-lymphocyte cell Bm3-delta B cell true A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive. GOC:add GOC:msz GOC:tfm GO_REF:0000031 PMID:9280752 A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative. Bm2' B lymphocyte Bm2' B-cell Bm2' B-lymphocyte Bm2-prime B cell Bm2-prime B lymphocyte Bm2-prime B-cell Bm2-prime B-lymphocyte cell germinal center founder cell Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. Bm2' B cell true A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative. GOC:dsd GOC:msz GOC:tfm GO_REF:0000031 PMID:17992590 PMID:18432934 PMID:8006591 A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type. Bm3 B lymphocyte Bm3 B-cell Bm3 B-lymphocyte cell centroblast Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive. Bm3 B cell true A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type. GOC:dsd GOC:msz GO_REF:0000031 PMID:18432934 PMID:8006591 centroblast PMID:8006591 A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor. Bm4 B lymphocyte Bm4 B-cell Bm4 B-lymphocyte cell centrocyte Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive. Bm4 B cell true A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor. GOC:dsd GOC:msz GO_REF:0000031 PMID:18432934 PMID:8006591 centrocyte PMID:17992590 A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes. Bm5 B lymphocyte Bm5 B-cell Bm5 B-lymphocyte cell Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative. Bm5 B cell A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes. GOC:dsd GOC:msz GOC:tfm GO_REF:0000031 PMID:18432934 PMID:8006591 A mature B cell that produces cytokines that can influence CD4 T cell differentiation. B effector cell effector B cell effector B lymphocyte effector B-cell effector B-lymphocyte cell Be cell true A mature B cell that produces cytokines that can influence CD4 T cell differentiation. GOC:msz GOC:tfm GO_REF:0000031 PMID:11101868 PMID:20224569 A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses. B(reg) B10 cell Breg regulatory B lymphocyte regulatory B-cell regulatory B-lymphocyte cell Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive. regulatory B cell true A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses. GOC:dsd GOC:msz GOC:tfm GO_REF:0000031 MESH:D060151 PMID:11869683 PMID:18482568 PMID:20224569 PMID:20809522 An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative. IgD+ memory B cell unswitched memory B lymphocyte unswitched memory B-cell unswitched memory B-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. unswitched memory B cell true An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative. GOC:add GOC:dsd GOC:rhs GO_REF:0000031 ISBN:0781765196 PMID:20933013 PMID:22343568 IgD+ memory B cell PMID:22343568 An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative. IgM memory B lymphocyte IgM memory B-cell IgM memory B-lymphocyte memory IgM B cell memory IgM B lymphocyte memory IgM B-cell memory IgM B-lymphocyte cell IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive. IgM memory B cell An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative. GOC:dsd GOC:rhs GO_REF:0000031 ISBN:0781765196 PMID:19447676 A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface. class switched memory B lymphocyte class switched memory B-cell class switched memory B-lymphocyte cell Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive. class switched memory B cell true A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface. GOC:add GOC:dsd GOC:rhs GO_REF:0000031 ISBN:0781765196 PMID:20933013 PMID:9295047 A class switched memory B cell that expresses IgA. IgA memory B lymphocyte IgA memory B-cell IgA memory B-lymphocyte memory IgA B cell memory IgA B lymphocyte memory IgA B-cell memory IgA B-lymphocyte cell IgA memory B cell are also reportedly RORalpha-positive. IgA memory B cell true A class switched memory B cell that expresses IgA. GOC:dsd GOC:msz GO_REF:0000031 ISBN:0781765196 A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow. cell long lived plasma cell true A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow. GOC:msz GOC:tfm GO_REF:0000031 ISBN:9780781765190 PMID:16014527 A fully differentiated plasma cell that lives for months. cell short lived plasma cell true A fully differentiated plasma cell that lives for months. GOC:msz GO_REF:0000031 PMID:16014527 A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system. cell IgA short lived plasma cell true A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system. GOC:msz GO_REF:0000031 ISBN:781735149 A short lived plasma cell that secretes IgG. cell IgG short lived plasma cell true A short lived plasma cell that secretes IgG. GOC:msz GO_REF:0000031 ISBN:781735149 A short lived plasma cell that secretes IgM. cell IgM short lived plasma cell true A short lived plasma cell that secretes IgM. GOC:msz GO_REF:0000031 ISBN:781735149 An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface. IgG memory B lymphocyte IgG memory B-cell IgG memory B-lymphocyte memory IgG B cell memory IgG B lymphocyte memory IgG B-cell memory IgG B-lymphocyte cell IgG memory B cell true An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface. GOC:rhs GO_REF:0000031 ISBN:0781765196 An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative. FMA:84371 cell This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative. plasmablast true An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative. GOC:dsd GOC:msz GOC:tfm GO_REF:0000031 PMCID:PMC2673126 A memory B cell with the phenotype IgD-negative and CD27-negative. dn memory B cell dn memory B lymphocyte dn memory B-cell dn memory B-lymphocyte double negative memory B lymphocyte double negative memory B-cell double negative memory B-lymphocyte cell double negative memory B cell A memory B cell with the phenotype IgD-negative and CD27-negative. GOC:msz GOC:tfm GO_REF:0000031 A plasmablast that secretes IgG. cell IgG plasmablast true A plasmablast that secretes IgG. GOC:msz GO_REF:0000031 A plasmablast that secretes IgM. cell IgM plasmablast true A plasmablast that secretes IgM. GOC:msz GO_REF:0000031 A plasmablast that secretes IgA. cell IgA plasmablast true A plasmablast that secretes IgA. GOC:msz GO_REF:0000031 A fully differentiated plasma cell that secretes IgG. cell IgG plasma cell true A fully differentiated plasma cell that secretes IgG. GOC:msz GO_REF:0000031 ISBN:781735149 A fully differentiated plasma cell that secretes IgM. cell IgM plasma cell true A fully differentiated plasma cell that secretes IgM. GOC:msz GO_REF:0000031 ISBN:781735149 A fully differentiated plasma cell that secretes IgA. cell IgA plasma cell true A fully differentiated plasma cell that secretes IgA. GOC:msz GO_REF:0000031 ISBN:781735149 A cell of a hematopoietic lineage. BTO:0000574 CALOHA:TS-2017 FMA:70366 FMA:83598 haematopoietic cell haemopoietic cell hemopoietic cell cell hematopoietic cell A cell of a hematopoietic lineage. GOC:add GO_REF:0000031 CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative. cell Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8). CD11c-low plasmacytoid dendritic cell true CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative. GOC:amm GOC:dsd GO_REF:0000031 PMID:15771572 PMID:17850486 Conventional dendritic cell is a dendritic cell that is CD11c-high. interdigitating cell veiled cell FMA:84191 DC1 cDC dendritic reticular cell type 1 DC cell Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. conventional dendritic cell true Conventional dendritic cell is a dendritic cell that is CD11c-high. GOC:amm GO_REF:0000031 PMID:17850486 CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive. CD303-positive dendritic cell cell Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10). CD11c-negative plasmacytoid dendritic cell true CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive. GOC:amm GO_REF:0000031 PMID:15771572 PMID:17850486 Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low. cell Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617). immature CD11c-low plasmacytoid dendritic cell true Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low. GOC:amm GO_REF:0000031 PMID:15771572 PMID:17850486 Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive. cell Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617). mature CD11c-low plasmacytoid dendritic cell true Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive. GOC:amm GO_REF:0000031 PMID:15771572 PMID:17850486 Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low. cell Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617). immature CD11c-negative plasmacytoid dendritic cell true Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low. GOC:amm GO_REF:0000031 PMID:15771572 PMID:17850486 CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid cell Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617). mature CD11c-negative plasmacytoid dendritic cell true Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm GO_REF:0000031 PMID:15771572 PMID:17850486 Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low. cell Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617). immature CD8_alpha-negative CD11b-positive dendritic cell true Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm GOC:tfm GO_REF:0000031 PMCID:PMC2346585 CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells. DC.8-4-11b- triple negative dendritic cell cell These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617). CD8_alpha-negative CD11b-negative dendritic cell true CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells. GOC:amm GO_REF:0000031 PMCID:PMC2346585 http:www.immgen.org/index_content.html CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative. DC.4+ cell Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617). CD4-positive CD11b-positive dendritic cell CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative. GOC:amm GOC:tfm GO_REF:0000031 PMCID:PMC2346585 CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive. DC.8+ cell Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617). CD8_alpha-positive CD11b-negative dendritic cell true CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive. GOC:amm GOC:tfm GO_REF:0000031 PMCID:PMC2346585 Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low. cell These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617). immature CD8_alpha-negative CD11b-negative dendritic cell true Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm GO_REF:0000031 PMCID:PMC2346585 Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617). mature CD8_alpha-negative CD11b-negative dendritic cell true Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm GOC:tfm GO_REF:0000031 PMCID:PMC2346585 Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617). mature CD8_alpha-negative CD11b-positive dendritic cell true Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm GOC:tfm GO_REF:0000031 PMCID:PMC2346585 Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low. cell Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617). immature CD8_alpha-positive CD11b-negative dendritic cell true Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm GOC:tfm GO_REF:0000031 PMCID:PMC2346585 Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617). mature CD8_alpha-positive CD11b-negative dendritic cell true Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm GO_REF:0000031 PMCID:PMC2346585 Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative. BTO:0004812 cell Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9). dermal dendritic cell Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative. GOC:amm GO_REF:0000031 PMCID:PMC2346585 Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive. cell Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10). interstitial dendritic cell Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive. GOC:amm GO_REF:0000031 PMID:17850486 A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative. LSK stem cell Sca1-positive hematopoietic stem cell cell Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). Kit and Sca1-positive hematopoietic stem cell true A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative. GOC:add GOC:amm GOC:tfm GO_REF:0000031 PMID:17952047 PMID:19022770 Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low. cell Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617). immature dermal dendritic cell true Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm GO_REF:0000031 PMCID:PMC2346585 Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617). mature dermal dendritic cell true Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm GO_REF:0000031 PMCID:PMC2346585 Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low. cell Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617). immature interstitial dendritic cell true Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm GOC:tfm GO_REF:0000031 PMID:17850486 cell Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617). mature interstitial dendritic cell true Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm GOC:tfm GO_REF:0000031 PMID:17850486 CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive. CD1a-LC cell These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15. CD1a-positive Langerhans cell true CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive. GOC:amm GO_REF:0000031 PMID:17850486 CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low. cell These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9). CD8_alpha-low Langerhans cell true CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low. GOC:amm GO_REF:0000031 PMCID:PMC2346585 Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low. cell Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617). immature CD1a-positive Langerhans cell true Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm GOC:tfm GO_REF:0000031 PMID:17850486 Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15. mature CD1a-positive Langerhans cell true Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm GOC:tfm GO_REF:0000031 PMID:17850486 Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low. cell These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617). immature CD8_alpha-low Langerhans cell true Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm GOC:tfm GO_REF:0000031 PMCID:PMC2346585 cell Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). CD115-positive monocyte OR common dendritic progenitor Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617). mature CD8_alpha-low Langerhans cell true Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm GO_REF:0000031 PMCID:PMC2346585 A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive. CD10-positive common lymphocyte precursor CD10-positive common lymphocyte progenitor CD10-positive common lymphoid precursor cell These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). CD34-positive, CD38-positive common lymphoid progenitor true A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive. GOC:add GOC:amm GOC:tfm GO_REF:0000031 PMCID:PMC2346585 PMID:19022770 CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive. cell These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). CD115-positive monocyte true CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive. GOC:add GOC:amm GO_REF:0000031 PMID:17952047 A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low. CD117-positive common myeloid precursor cell Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). Kit-positive, CD34-positive common myeloid progenitor true A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low. GOC:add GOC:amm GOC:tfm GO_REF:0000031 PMID:1261582 PMID:17952047 http://www.immgen.org/index_content.html CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive. CALOHA:TS-0448 FMA:86475 CD133-positive hematopoietic stem cell cell Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). CD34-positive, CD38-negative hematopoietic stem cell true CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive. GOC:add GOC:amm GOC:tfm GO_REF:0000031 PMID:10430905 PMID:11750107 PMID:16551251 PMID:20024907 PMID:9389721 CD133-positive hematopoietic stem cell PMID:16140871 A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low. CD217-positive common lymphocyte precursor CD217-positive common lymphocyte progenitor CD217-positive common lymphoid precursor cell Markers are associated with mouse cells. Kit-positive, Sca1-positive common lymphoid progenitor true A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low. GOC:add GOC:amm GOC:tfm GO_REF:0000031 PMID:17952047 http://www.immgen.org/index_content.html A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative. CD71-positive common myeloid precursor cell Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). CD34-positive, CD38-positive common myeloid progenitor A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative. GOC:add GOC:amm GO_REF:0000031 PMCID:PMC2626675 PMID:16551251 CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative. CD7-negative lymphoid precursor cell These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). CD7-negative lymphoid progenitor cell true CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative. GOC:amm GO_REF:0000031 PMID:16551251 CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative. CD7-positive lymphoid precursor cell These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). CD7-positive lymphoid progenitor cell true CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative. GOC:amm GOC:tfm GO_REF:0000031 PMID:16551251 PMID:19491395 Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers. CDP common dendritic precursor pro-DCs cell Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). common dendritic progenitor Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers. GOC:amm GOC:tfm GO_REF:0000031 PMID:16551251 PMID:17922016 PMID:19286519 CDP PMID:21219184 pro-DCs PMID:21219184 cell Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor Granule cell that is part of the cerebellum. BTO:0004278 cell cerebellar granule cell true Granule cell that is part of the cerebellum. GOC:mah Granule cell that is part of the cerebral cortex. cell cortical granule cell Granule cell that is part of the cerebral cortex. GOC:mah Granule cell that is part of the hippocampus. cell hippocampal granule cell Granule cell that is part of the hippocampus. GOC:mah A cell that is maintained or propagated in a controlled artificial environment for use in an investigation. haendel 2012-01-12T09:58:38Z cell 'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells. cell in vitro A cell that is maintained or propagated in a controlled artificial environment for use in an investigation. ReO:mhb A connective tissue cell found in bone. adiehl 2011-11-16T04:28:16Z cell bone cell true A connective tissue cell found in bone. GOC:add GO_REF:0000034 Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix. VSAO:0000116 cl terminally differentiated osteoblast Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix. VSAO:curator Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone. VSAO:0000117 cl VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 non-terminally differentiated osteoblast Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone. VSAO:curator A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production. CD8+CXCR3+ T cell CD8+CXCR3+ T lymphocyte CD8+CXCR3+ T(reg) CD8+CXCR3+ T-cell CD8+CXCR3+ T-lymphocyte CD8+CXCR3+ Treg CD8-positive, CXCR3-positive, T(reg) CD8-positive, CXCR3-positive, Treg CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte cell These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction. CD8-positive, CXCR3-positive, alpha-beta regulatory T cell true A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production. GOC:dsd PMID:19609979 CD4-positive, alpha-beta T cell that produces IL-22. T(H)-22 cell Th22 T cell Th22 T lymphocyte Th22 T-cell Th22 T-lymphocyte Th22 cell helper T cell type 22 cell TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13. T-helper 22 cell true CD4-positive, alpha-beta T cell that produces IL-22. GOC:dsd PMID:19578368 PMID:19578369 A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive. activated CD4+ T cell activated CD4-positive, alpha-beta T lymphocyte, human activated CD4-positive, alpha-beta T-cell, human activated CD4-positive, alpha-beta T-lymphocyte, human cell This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. activated CD4-positive, alpha-beta T cell, human A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive. GOC:add PMID:22343568 activated CD4+ T cell PMID:22343568 A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive. effector CD4+ T cell effector CD4-positive, alpha-beta T lymphocyte effector CD4-positive, alpha-beta T-cell effector CD4-positive, alpha-beta T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. effector CD4-positive, alpha-beta T cell A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive. GOC:add PMID:22343568 effector CD4+ T cell PMID:22343568 A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative. naive CCR4+ Treg naive CCR4-positive regulatory T lymphocyte naive CCR4-positive regulatory T-cell naive CCR4-positive regulatory T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. naive CCR4-positive regulatory T cell A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative. GOC:add PMID:22343568 naive CCR4+ Treg PMID:22343568 A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive. memory CCR4+ Treg memory CCR4-positive regulatory T lymphocyte memory CCR4-positive regulatory T-cell memory CCR4-positive regulatory T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. memory CCR4-positive regulatory T cell A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive. GOC:add PMID:22343568 memory CCR4+ Treg PMID:22343568 A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive. CCR+ Treg CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive. GOC:add PMID:22343568 CCR+ Treg PMID:22343568 A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation. activated CCR4+ Treg activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation. GOC:add PMID:22343568 activated CCR4+ Treg PMID:22343568 A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive. activated CD8+ T cell activated CD8-positive, alpha-beta T lymphocyte, human activated CD8-positive, alpha-beta T-cell, human activated CD8-positive, alpha-beta T-lymphocyte, human cell This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II. activated CD8-positive, alpha-beta T cell, human A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive. GOC:add PMID:22343568 activated CD8+ T cell PMID:22343568 A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive. effector CD8+ T cell effector CD8-positive, alpha-beta T lymphocyte effector CD8-positive, alpha-beta T-cell effector CD8-positive, alpha-beta T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. effector CD8-positive, alpha-beta T cell A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive. GOC:add PMID:22343568 effector CD8+ T cell PMID:22343568 A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative. non-Th1/Th17 CD4+ T cell CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells. CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative. GOC:add PMID:22343568 non-Th1/Th17 CD4+ T cell PMID:22343568 A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative. non-Tc1/Tc17 CD8+ T cell CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'. Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells. CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative. GOC:add PMID:22343568 non-Tc1/Tc17 CD8+ T cell PMID:22343568 A memory B cell that lacks expression of surface IgD. IgD- memory B cell cell This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive. IgD-negative memory B cell A memory B cell that lacks expression of surface IgD. GOC:add PMID:22343568 IgD- memory B cell PMID:22343568 A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20. monocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. CD14-positive monocyte A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20. GOC:add PMID:22343568 monocyte PMID:22343568 An intermediate monocyte that is CD14-positive and with low amounts of CD16. intermediate monocyte, human cell Definition is valid for human intermediate monocytes. CD14-positive, CD16-low monocyte An intermediate monocyte that is CD14-positive and with low amounts of CD16. GOC:add PMID:20628149 A dendritic cell with the phenotype HLA-DRA-positive. dendritic cell cell This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells. dendritic cell, human A dendritic cell with the phenotype HLA-DRA-positive. GOC:add PMID:22343568 dendritic cell PMID:22343568 A myeloid dendritic cell with the phenotype HLA-DRA-positive. myeloid dendritic cell cell This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells. myeloid dendritic cell, human A myeloid dendritic cell with the phenotype HLA-DRA-positive. GOC:add PMID:22343568 myeloid dendritic cell PMID:22343568 A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative. plasmacytoid dendritic cell cell This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells. plasmacytoid dendritic cell, human A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative. GOC:add PMID:22343568 plasmacytoid dendritic cell PMID:22343568 A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1. CMP common myeloid precursor, CD34-positive cell CFU-GEMM CFU-S colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell pluripotent stem cell (bone marrow) CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. common myeloid progenitor, CD34-positive A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1. GOC:add GOC:dsd GOC:tfm ISBN:0878932437 PMCID:PMC2212039 PMID:10724173 PMID:16551251 PMID:16647566 CMP ISBN:0878932437 CFU-GEMM ISBN:0878932437 CFU-S ISBN:0878932437 colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte ISBN:0878932437 multipotential myeloid stem cell ISBN:0878932437 myeloid stem cell ISBN:0878932437 pluripotent stem cell (bone marrow) ISBN:0878932437 A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. tmeehan 2010-01-06T03:43:27Z cell hematopoietic oligopotent progenitor cell, lineage-negative A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. GOC:tfm PMID:19022770 A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models. 2017-01-30T18:53:32Z https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913 cell https://github.com/obophenotype/cell-ontology/issues/448 abnormal cell A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models. GOC:add GOC:cg GOC:wdd A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative. TEMRA cell This cell type is seen human but not found in the mouse. effector memory CD8-positive, alpha-beta T cell, terminally differentiated A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative. GOC:add GOC:dos PMID:15032595 PMID:16237082 TEMRA PMID:16237082 An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism. 2017-01-30T19:16:26Z https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922 cell tumor cell tumour cell https://github.com/obophenotype/cell-ontology/issues/448 neoplastic cell An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism. GOC:add GOC:cg GOC:wdd A neoplastic cell that is capable of entering a surrounding tissue 2017-01-30T19:39:12Z https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917 cell cancer cell https://github.com/obophenotype/cell-ontology/issues/448 malignant cell A neoplastic cell that is capable of entering a surrounding tissue GOC:add GOC:cg GOC:wdd A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses. 2017-01-30T20:20:48Z cell innate lymphoid cell A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses. GOC:add GOC:dsd PMID:23292121 PMID:23348417 A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). BTO:0004911 cell BFU-E CFU-E blast forming unit erythroid burst forming unit erythroid colony forming unit erythroid erythroid stem cell erythroid progenitor cell, mammalian A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). GOC:add ISBN:0721601464 An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines. 2017-01-30T20:42:44Z cell group 1 innate lymphoid cell An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines. GOC:add GOC:dsd PMID:23348417 A group 1 innate lymphoid cell that is non-cytotoxic. 2017-01-30T20:54:12Z cell ILC1 A group 1 innate lymphoid cell that is non-cytotoxic. GOC:add GOC:dsd PMID:23292121 PMID:23348417 An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation. 2017-01-30T21:20:08Z ILC2 nuocyte cell group 2 innate lymphoid cell An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation. GOC:add GOC:dsd PMID:23292121 PMID:23562755 A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor. beige brown adipocyte beige fat cell beige/brite adipocyte brite adipocyte brite cell brite fat cell cell beige adipocyte A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor. GOC:add GOC:cvs GOC:ymb PMID:22796012 PMID:25851693 An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22. 2017-01-31T20:21:26Z ILC3 cell group 3 innate lymphoid cell An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22. GOC:add GOC:dsd PMID:23292121 PMID:23348417 FBbt:00004230 cell visual pigment cell (sensu Nematoda and Protostomia) An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative. tmeehan 2010-04-26T10:14:16Z c- Kit-positive erythroid progenitor cell cell Markers found on mouse cells. Kit-positive erythroid progenitor cell true An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative. GOC:ak GOC:tfm PMID:19805084 http://www.immgen.org/index_content.html A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative. tmeehan 2010-01-13T03:19:22Z cell Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. CD34-positive, CD38-positive granulocyte monocyte progenitor true A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative. GOC:tfm PMID:12615892 PMID:19022770 A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative. tmeehan 2010-01-13T03:19:28Z cell Markers are found on mouse cells. Kit-positive granulocyte monocyte progenitor true A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative. GOC:tfm PMID:12615892 PMID:16322423 PMID:19022770 PMID:19273628 http://www.immgen.org/index_content.html An erythroid progenitor cell that is CD34-positive and is GlyA-negative. tmeehan 2010-04-26T10:14:30Z FMA:83517 cell Cell markers associated with human cells. CD34-positive, GlyA-negative erythroid progenitor cell true An erythroid progenitor cell that is CD34-positive and is GlyA-negative. GOC:ak GOC:tfm PMID:19621348 A proerythoblast that is CD34-negative and GlyA-negative. tmeehan 2010-04-26T10:31:50Z cell Cell surface markers are associated with human cells. CD34-negative, GlyA-negative proerythroblast true A proerythoblast that is CD34-negative and GlyA-negative. GOC:ak GOC:tfm PMID:19621348 A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative. tmeehan 2010-01-13T03:43:10Z cell Markers are associated with human cell type. CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell true A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative. GOC:tfm PMID:12615892 PMID:190227700 A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low. tmeehan 2010-01-13T03:43:12Z cell Markers are associated with mouse cells. Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell true A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low. GOC:tfm PMID:12615892 PMID:19022770 http://www.immgen.org/index_content.html A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell. tmeehan 2010-01-14T03:25:15Z cell Markers are found on mouse cells. Kit-low, CD34-positive eosinophil progenitor cell true A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell. GOC:tfm PMID:17582345 A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell. tmeehan 2010-01-14T03:25:17Z cell Markers are associated with human cells. CD34-positive, CD38-positive eosinophil progenitor cell true A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell. GOC:tfm PMCID:PMC2626675 A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. tmeehan 2010-01-19T02:51:58Z MDP cell macrophage dendritic cell progenitor true A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. GOC:tfm PMID:19273628 A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha. tmeehan 2010-01-19T03:39:30Z cell pre-conventional dendritic cell true A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha. GOC:tfm A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative. tmeehan 2010-01-26T02:43:40Z murine MDP cell Markers are associated with mouse cells. Kit-positive macrophage dendritic cell progenitor true A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative. GOC:tfm PMID:19273628 A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive. tmeehan 2010-04-26T10:31:56Z cell Markers are associated with mouse cells. Kit-low proerythroblast true A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive. GOC:ak GOC:tfm PMID:19805084 A basophilic erythroblast that is GlyA-positive. tmeehan 2010-04-26T10:41:15Z cell Markers are associated with human cells. GlyA-positive basophillic erythroblast true A basophilic erythroblast that is GlyA-positive. GOC:ak GOC:tfm PMID:1638021 A basophilic erythroblast that is Lyg 76-high and is Kit-negative. tmeehan 2010-04-26T10:41:22Z cell Cell surface markers are associated with mouse cells. Kit-negative, Ly-76 high basophilic erythroblast true A basophilic erythroblast that is Lyg 76-high and is Kit-negative. GOC:ak GOC:tfm PMID:19805084 A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative. tmeehan 2010-04-26T10:53:11Z late basophilic and polychromatophilic erythroblast cell Kit-negative, Ly-76 high polychromatophilic erythroblast true A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative. GOC:ak GOC:tfm PMID:19805084 A polychromatiic erythroblast that is Gly-A-positive and CD71-low. tmeehan 2010-04-26T10:53:16Z cell Cell surface markers are associated with human cells. CD71-low, GlyA-positive polychromatic erythroblast true A polychromatiic erythroblast that is Gly-A-positive and CD71-low. GOC:ak GOC:tfm PMID:1638021 An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative. tmeehan 2010-04-26T11:04:15Z cell Cell surface markers associated with mouse cells. Kit-negative, Ly-76 high orthochromatophilic erythroblasts true An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative. GOC:ak GOC:tfm PMID:19805084 An erythroblast that is GlyA-positive and CD71-negative. tmeehan 2010-04-26T11:04:21Z cell Markers associated with human cells. CD71-negative, GlyA-positive orthochromatic erythroblast true An erythroblast that is GlyA-positive and CD71-negative. GOC:ak GOC:tfm PMID:1638021 A reticulocyte that is Ly76-high and is Kit-negative. tmeehan 2010-04-26T11:37:00Z cell Marker associated with mouse cells. Ly-76 high reticulocyte true A reticulocyte that is Ly76-high and is Kit-negative. GOC:ak GOC:tfm PMID:18539294 A reticulocyte that is GlyA-positive. tmeehan 2010-04-26T11:48:25Z cell Markers is associated with human cells. GlyA-positive reticulocytes true A reticulocyte that is GlyA-positive. GOC:ak GOC:tfm PMID:1638021 An enucleate erythrocyte that is GlyA-positive. tmeehan 2010-04-26T11:51:22Z cell Marker is associated with human cell types. GlyA-positive erythrocyte true An enucleate erythrocyte that is GlyA-positive. GOC:ak GOC:tfm PMID:20134094 An enucleate erythrocyte that is Lyg-76-high. tmeehan 2010-04-26T11:51:27Z cell Marker is associated with mouse cell types. Ly-76 high positive erythrocyte true An enucleate erythrocyte that is Lyg-76-high. GOC:ak GOC:tfm PMID:19805084 A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface. tmeehan 2010-04-26T02:39:09Z cell Markers are associated with human cell type. CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell true A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface. GOC:ak GOC:tfm PMID:15232614 A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low. tmeehan 2010-04-26T02:39:15Z cell Markers are associated with mouse cells. Kit-positive megakaryocyte progenitor cell true A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low. GOC:ak GOC:tfm PMID:16951553 A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative. tmeehan 2010-04-26T03:52:47Z cell Markers are commonly associated with human cells. CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell true A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative. GOC:ak GOC:tfm PMID:15232614 A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive. tmeehan 2010-04-26T03:59:22Z cell Markers are commonly associated with human cells. CD34-negative, CD41-positive, CD42-positive megakaryocyte cell true A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive. GOC:ak GOC:tfm PMID:15232614 A megakaryocyte cell with is CD9-positive and CD41-positive. tmeehan 2010-04-27T10:39:07Z cell Markers are commonly associated with mouse cells. CD9-positive, CD41-positive megakaryocyte cell true A megakaryocyte cell with is CD9-positive and CD41-positive. GOC:tfm A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa tmeehan 2010-04-27T12:46:33Z BMCP cell There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low. basophil mast progenitor cell A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa GOC:ak GOC:dsd GOC:tfm PMCID:PMC1312421 A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low. tmeehan 2010-04-27T01:22:19Z cell Fc-epsilon RIalpha-low mast cell progenitor true A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low. GOC:tfm PMCID:PMC1312421 A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high. tmeehan 2010-04-27T01:22:32Z cell Markers are associated with mouse cells. Fc-epsilon RIalpha-high basophil progenitor cell true A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high. GOC:tfm PMCID:PMC1312421 A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. tmeehan 2010-01-06T03:43:20Z cell hematopoietic lineage restricted progenitor cell A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. GOC:tfm PMID:19022770 A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. tmeehan 2010-01-06T03:43:27Z cell This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). hematopoietic oligopotent progenitor cell A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. GOC:tfm PMID:19022770 A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative. tmeehan 2010-01-08T09:19:25Z ST stem cell ST-HSC cell Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. short term hematopoietic stem cell true A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative. GOC:tfm PMID:15572596 PMID:19022770 A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative. tmeehan 2010-01-08T09:19:28Z LT stem cell LT-HSC cell Markers are associated with mouse cells. long term hematopoietic stem cell true A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative. GOC:tfm PMID:15572596 PMID:17582345 A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative. tmeehan 2010-01-08T11:16:33Z cell Markers are associated with mouse cells. Slamf1-negative multipotent progenitor cell true A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative. GOC:tfm PMID:19022770 A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive. tmeehan 2010-01-08T11:16:35Z KSL cell cell Markers are associated with mouse cells. Slamf1-positive multipotent progenitor cell true A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive. GOC:tfm PMID:19022770 Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive. tmeehan 2009-10-20T02:20:43Z memory alpha beta IEL cell CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell true Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive. GOC:tfm PMID:16048545 memory alpha beta IEL PMID:16048545 A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production. tmeehan 2009-10-29T04:01:27Z T(FH) Tfh cell follicular B helper T cell follicular T cell follicular T-cell follicular T-helper cell follicular helper T cell follicular helper T-cell T follicular helper cell true A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production. GOC:tfm PMID:19855402 PMID:20107805 PMID:22043829 T(FH) PMID:20207847 Tfh PMID:20107805 PMID:20383172 follicular B helper T cell PMID:22043829 follicular T cell PMID:20107805 PMID:21914188 follicular T-helper cell PMID:22552227 follicular helper T cell PMID:22649468 follicular helper T-cell PMID:22508770 A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell. tmeehan 2009-10-29T04:09:16Z cell immature NK T cell stage I true A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell. GOC:tfm PMID:17589542 A CD24-low, CD44-negative, NK1.1-negative NK T cell. tmeehan 2009-10-29T04:13:43Z NKT.44-NK1.1-.Th cell NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. immature NK T cell stage II true A CD24-low, CD44-negative, NK1.1-negative NK T cell. GOC:tfm PMID:17589542 http://www.immgen.org/index_content.html A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell. tmeehan 2009-10-29T04:14:48Z NKT.44+.NK1.1-.Th cell immature NK T cell stage III true A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell. PMID:17589542 A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell. tmeehan 2009-10-29T04:17:38Z NKT.44+.NK1.1-.Th cell immature NK T cell stage IV true A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell. GOC:tfm PMID:17589542 http://www.immgen.org/index_content.html A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative. tmeehan 2010-01-12T11:14:15Z cell Cell markers are associated with human hematopoietic multipotent progenitor cells. CD34-positive, CD38-negative multipotent progenitor cell true A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative. GOC:tfm PMID:18371405 PMID:19022770 A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative. tmeehan 2010-04-27T01:22:38Z cell Markers are associated with mouse cells. Kit-positive, integrin beta7-high basophil mast progenitor cell true A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative. GOC:ak GOC:tfm A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. tmeehan 2010-04-28T10:50:07Z fraction A cell pre pro B cell Markers associated with mouse cells. Fraction A pre-pro B cell true A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. GOC:ak GOC:tfm PMID:12633665 PMID:17582343 http://www.immgen.org/index_content.html A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage. tmeehan 2010-04-28T11:19:11Z cell Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. early pro-B cell true A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage. GOC:dsd GOC:tfm PMID:18432934 A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative. tmeehan 2010-04-28T11:56:21Z Fr. B Fraction B cell Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive. Fraction B precursor B cell true A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative. GOC:ak GOC:tfm PMID:18432934 A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive. tmeehan 2010-04-28T12:06:06Z cell Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. late pro-B cell true A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive. GOC:dsd GOC:tfm PMID:18432934 A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain. tmeehan 2010-04-28T02:04:01Z cell Fraction C Fraction C precursor B cell true A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain. GOC:tfm PMID:17582343 A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive. tmeehan 2010-04-28T02:13:46Z Fr. C' Fraction C-prime cell Fraction C' precursor B cell true A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive. GOC:tfm PMID:17582343 A pre-BCR positive T cell that is CD38-high. tmeehan 2010-04-28T02:27:47Z cell large pre-B cell type I Markers are associated with human cells. CD38-high pre-BCR positive cell true A pre-BCR positive T cell that is CD38-high. GOC:tfm PMID:18432934 A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive. tmeehan 2010-04-28T02:55:16Z Fr. D Fraction D pre-B cell cell Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative. Fraction D precursor B cell A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive. GOC:ak GOC:dsd GOC:tfm PMID:17582343 PMID:18432934 http://www.immgen.org/index_content.html Fraction D pre-B cell GOC:tfm A small pre-B cell that is CD22-positive and CD38-low. tmeehan 2010-04-28T03:04:48Z small pre-B cell cell Markers are associated with human cell. RAG expression maybe diminishing. CD22-positive, CD38-low small pre-B cell true A small pre-B cell that is CD22-positive and CD38-low. GOC:tfm PMID:18432934 An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive. tmeehan 2010-04-28T03:13:47Z cell Markers associated with mouse cells. These cells are also reportedly sIgD-negative. Fraction E immature B cell true An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive. GOC:ak GOC:dsd GOC:tfm PMID:17582343 PMID:18432934 An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high. tmeehan 2010-04-28T03:19:14Z cell Markers are associated with human cell type. CD38-negative immature B cell true An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high. GOC:tfm PMID:18432934 A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative. tmeehan 2010-04-30T03:01:48Z cell Fraction F mature B cell A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative. GOC:tfm PMID:17582343 A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive. tmeehan 2010-06-05T08:25:41Z CD16- monocyte CD16-negative monocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes. CD14-positive, CD16-negative classical monocyte true A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive. GOC:add GOC:tfm PMID:15615263 PMID:1706877 PMID:19689341 PMID:22343568 CD16- monocyte PMID:22343568 A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive. tmeehan 2010-06-05T08:25:44Z cell Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative. Gr1-low non-classical monocyte true A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive. GOC:tfm PMID:8890901 A conventional thymic dendritic cell that is CD8alpha-positive. tmeehan 2010-06-07T02:48:36Z CD8alpha-alpha-positive thymic conventional dendritic cell DC.8+.Th cell CD8alpha-positive thymic conventional dendritic cell true A conventional thymic dendritic cell that is CD8alpha-positive. GOC:tfm PMID:19273629 http://www.immgen.org/index_content.html A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes. tmeehan 2010-06-22T10:46:12Z cell melanophage true A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes. GOC:tfm PMID:20479296 PMID:2943821 A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed. tmeehan 2010-06-22T11:18:44Z T helper cells type 9 T(H)-9 cell Th9 cell T-helper 9 cell true A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed. GOC:tfm PMID:18931678 PMID:19604299 PMID:20154671 Th9 PMID:18931678 A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. tmeehan 2010-06-23T04:37:54Z BTO:0000780 FMA:62500 AT1 ATI lung type 1 cells membranous pneumocytes pulmonary alveolar type I cell small alveolar cells squamous alveolar cell squamous alveolar lining cell type 1 alveolar epithelial cells type 1 pneumocyte type I alveolar cells type I alveolar epithelial cells cell type I pneumocyte A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. GOC:tfm PMID:20054144 http://www.copewithcytokines.de A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli. tmeehan 2010-06-24T12:04:13Z BTO:0000538 FMA:62501 AT2 ATII TII cuboidal type II cell granular pneumocyte great alveolar cell lung type 2 cell type 2 alveolar epithelial cell type 2 alveolocyte type 2 pneumocyte type II alveolar cell type II alveolar epithelial cell type II alveolocyte cell lung type II cell type II pneumocyte A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli. GOC:tfm ISBN:0412046911 PMID:8540632 http://www.copewithcytokines.de A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. tmeehan 2010-06-24T03:16:29Z BTO:0000028 CALOHA:TS-0737 FMA:63032 acinar cell of pancreas cell pancreatic acinar cell true A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. GOC:tfm ISBN:0517223651 PMID:20395539 http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane. tmeehan 2010-06-28T08:24:30Z P cell FMA:14118 Kultschitzky cell of bronchiole bronchiolar Kulchitsky cell respiratory enterochromaffin cell cell Feyrter cell A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane. GOC:tfm ISBN:0412046911 ISBN:0517223651 An enterocrine cell that produces glucagon. tmeehan 2010-09-10T10:48:54Z FMA:62939 cell type A enterocrine cell An enterocrine cell that produces glucagon. GOC:tfm ISBN:0412046911 Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. tmeehan 2010-06-28T08:36:15Z BTO:0001032 FMA:14146 Purkinje cell fiber Purkinje muscle cell myocytus conducens cardiacus cell Purkinje myocyte Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. FMA:0412046911 GOC:tfm PMID:19939742 Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices. tmeehan 2010-06-29T09:58:13Z FMA:67909 type 2 vestibular hair cell type 2 vestibular sensory cell type II hair cell cell type II vestibular sensory cell Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices. GOC:tfm ISBN:0517223651 Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending. tmeehan 2010-06-29T09:58:19Z FMA:62352 type 1 vestibular hair cell type 1 vestibular sensory cell type I hair cell cell type I vestibular sensory cell Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending. GOC:tfm ISBN:0517223651 Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type. tmeehan 2010-06-29T11:07:25Z columnar cell BTO:0002484 FMA:63638 FMA:66771 columnar cell of the colon vacuolar absorptive cell cell enterocyte of epithelium of large intestine true Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type. GOC:tfm ISBN:0517223651 A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. tmeehan 2010-06-29T11:41:37Z pacemaker cell BTO:0004190 FMA:67101 P cell cardiac pacemaker cell myocytus nodalis cell nodal myocyte A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. FMA:67101 GOC:tfm cardiac pacemaker cell GOC:pr Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. tmeehan 2010-06-29T02:39:32Z FMA:67142 cell transitional myocyte Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. FMA:67142 GOC:tfm The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). tmeehan 2010-06-29T11:50:47Z FMA:67111 cell myocardial endocrine cell The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). FMA:67111 GOC:tfm Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known. tmeehan 2010-06-29T03:22:46Z cell pulmonary brush cell brush cell of trachebronchial tree Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known. GOC:tfm ISBN:0517223651 PMID:15817800 An epithelial cell derived from endoderm. tmeehan 2010-06-29T03:38:14Z FMA:69075 cell endo-epithelial cell An epithelial cell derived from endoderm. FMA:69075 GOC:tfm An epithelial cell derived from ectoderm. tmeehan 2010-06-29T03:38:22Z FMA:69074 cell ecto-epithelial cell An epithelial cell derived from ectoderm. FMA:69074 GOC:tfm Epithelial cell derived from mesoderm or mesenchyme. tmeehan 2010-06-29T03:49:14Z FMA:69076 epithelial mesenchymal cell cell meso-epithelial cell Epithelial cell derived from mesoderm or mesenchyme. FMA:69076 GOC:tfm Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. tmeehan 2010-06-30T08:49:43Z FMA:63099 cell pancreatic ductal cell Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. FMA:63099 GOC:tfm PMID:14740223 A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. tmeehan 2010-06-30T08:49:52Z FMA:62455 centroacinar cell of Langerhans pancreatic centroacinar cell cell pancreatic centro-acinar cell A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. GOC:tfm PMID:12142741 PMID:20018761 PMID:8185160 This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery. tmeehan 2010-06-30T04:23:42Z FMA:84187 sheath cell of carotid body cell type II cell of carotid body This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery. GOC:tfm PMID:7938227 http://en.wikipedia.org/wiki/Carotid_body A chromaffin cell of the adrenal medulla that produces epinephrine. tmeehan 2010-07-14T09:41:42Z FMA:69322 adremergic chromaffin cell adrenal secreting cell of the adrenal medulla epiniphrine secreting cell of the adrenal medulla cell type II cell of adrenal medulla true A chromaffin cell of the adrenal medulla that produces epinephrine. GOC:tfm A chromaffin cell of the adrenal medulla that produces norepinephrine. tmeehan 2010-07-14T10:12:24Z FMA:69321 noradrenergic chromaffin cell cell type I cell of adrenal medulla true A chromaffin cell of the adrenal medulla that produces norepinephrine. GOC:tfm ISBN:068340007X A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport. tmeehan 2010-07-14T03:22:02Z Boettcher's cell Bottcher cell Bottcher's cell cell Boettcher cell A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport. GOC:tfm http://en.wikipedia.org/wiki/Boettcher_cell Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle. tmeehan 2010-07-15T11:21:11Z CL:0000643 BTO:0001953 FMA:54560 stretch cell cell tanycyte Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle. GOC:tfm http://neurolex.org/wiki/Category:Tanycyte A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. tmeehan 2010-07-21T01:33:38Z FMA:67968 cell specialized cardiac myocyte A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. FMA:67968 GOC:tfm A leukocyte that lacks granules. tmeehan 2010-07-22T11:30:33Z FMA:62855 agranular leukocyte cell nongranular leukocyte true A leukocyte that lacks granules. GOC:tfm This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. tmeehan 2010-07-22T03:26:00Z BTO:0003914 FMA:86573 ICC intestinal pacemaker cell cell Some argue this cell type is of mesenchymal origin. interstitial cell of Cajal true This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. GOC:tfm PMID:16460275 PMID:19520112 intestinal pacemaker cell GOC:pr A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive. tmeehan 2010-08-12T02:22:19Z nuocyte cell group 2 innate lymphoid cell, mouse true A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive. GOC:add GOC:tfm PMID:20200518 One of two small cells formed by the first and second meiotic division of oocytes. tmeehan 2010-08-23T09:49:53Z EHDAA2:0004716 FMA:85543 WBbt:0008429 XAO:0000262 cell polar body One of two small cells formed by the first and second meiotic division of oocytes. GOC:tfm ISBN:068340007X http://en.wikipedia.org/wiki/Polar_body A small cell formed by the first meiotic division of oocytes. tmeehan 2010-08-23T09:49:58Z EHDAA2:0000541 EMAPA:16032 FMA:18650 VHOG:0000464 first polar body polocytus primarius cell primary polar body A small cell formed by the first meiotic division of oocytes. GOC:tfm ISBN:068340007X first polar body EHDAA2:0000541 polocytus primarius FMA:18650 A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. tmeehan 2010-07-22T04:48:15Z BTO:0004850 FMA:83621 cell MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. bone marrow cell true A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. GOC:tfm ISBN:0618947256 A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell. tmeehan 2010-08-23T09:50:01Z EHDAA2:0001820 EMAPA:16034 EMAPA:16045 FMA:18651 polocytus secundarius second polar body cell secondary polar body A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell. GOC:tfm ISBN:068340007X polocytus secundarius FMA:18651 second polar body EHDAA2:0001820 A cell that makes up the loose connective tissue of the ovary. tmeehan 2010-08-23T11:11:34Z FMA:18709 cell interstitial cell of ovary A cell that makes up the loose connective tissue of the ovary. GOC:tfm A cell in the hilum of the ovary that produces androgens. tmeehan 2010-08-23T11:18:18Z FMA:18710 hilar cell of ovary cell hilus cell of ovary A cell in the hilum of the ovary that produces androgens. GOC:tfm ISBN:068340007X A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals. tmeehan 2010-08-23T11:24:11Z FMA:223275 cell internodal tract myocyte A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals. GOC:tfm ISBN:0781729300 A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol. tmeehan 2010-08-24T01:37:44Z FMA:69545 adrenal cortex cell adrenocortical cell cell cortical cell of adrenal gland true A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol. GOC:tfm A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval. tmeehan 2010-08-23T11:33:10Z FMA:67967 regular cardiac muscle cell regular cardiac muscle fiber cell regular cardiac myocyte A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval. GOC:tfm A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids. tmeehan 2010-08-24T01:42:02Z CL:1000423 FMA:69273 epithelial cell of zona glomerulosa of adrenal gland cell type I cell of adrenal cortex true A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids. GOC:tfm ISBN:0517223651 A regular cardiac myocyte of the interventricular region of the heart. tmeehan 2010-08-23T11:40:52Z FMA:228792 cell regular interventricular cardiac myocyte A regular cardiac myocyte of the interventricular region of the heart. GOC:tfm A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery. CD38+ naive B cell CD38+ naive B lymphocyte CD38+ naive B-cell CD38+ naive B-lymphocyte CD38-positive naive B lymphocyte CD38-positive naive B-cell CD38-positive naive B-lymphocyte cell CD38-positive naive B cell true A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery. CD38- naive B cell CD38- naive B lymphocyte CD38- naive B-cell CD38- naive B-lymphocyte CD38-negative naive B lymphocyte CD38-negative naive B-cell CD38-negative naive B-lymphocyte cell CD38-negative naive B cell true A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative. IgG+ dn memory B cell IgG+ dn memory B lymphocyte IgG+ dn memory B-cell IgG+ dn memory B-lymphocyte IgG+ double negative memory B cell IgG+ double negative memory B lymphocyte IgG+ double negative memory B-cell IgG+ double negative memory B-lymphocyte IgG-positive dn memory B cell IgG-positive dn memory B lymphocyte IgG-positive dn memory B-cell IgG-positive dn memory B-lymphocyte IgG-positive double negative memory B lymphocyte IgG-positive double negative memory B-cell IgG-positive double negative memory B-lymphocyte cell IgG-positive double negative memory B cell true An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative. IgG- dn memory B cell IgG- dn memory B lymphocyte IgG- dn memory B-cell IgG- dn memory B-lymphocyte IgG- double negative memory B cell IgG- double negative memory B lymphocyte IgG- double negative memory B-cell IgG- double negative memory B-lymphocyte IgG-negative dn memory B cell IgG-negative dn memory B lymphocyte IgG-negative dn memory B-cell IgG-negative dn memory B-lymphocyte IgG-negative double negative memory B lymphocyte IgG-negative double negative memory B-cell IgG-negative double negative memory B-lymphocyte cell IgG-negative double negative memory B cell true An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive. CD38+ IgG memory B cell CD38+ IgG memory B lymphocyte CD38+ IgG memory B-cell CD38+ IgG memory B-lymphocyte CD38-positive IgG memory B lymphocyte CD38-positive IgG memory B-cell CD38-positive IgG memory B-lymphocyte cell CD38-positive IgG memory B cell true A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive. cell IgD-positive CD38-positive IgG memory B cell true An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive. cell IgD-negative CD38-positive IgG memory B cell true An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive. cell CD38-negative IgG memory B cell true A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery. B220+CD38+ naive B cell B220+CD38+ naive B lymphocyte B220+CD38+ naive B-cell B220+CD38+ naive B-lymphocyte B220-positive CD38-positive naive B lymphocyte B220-positive CD38-positive naive B-cell B220-positive CD38-positive naive B-lymphocyte CD38+B220+ naive B cell CD38+B220+ naive B lymphocyte CD38+B220+ naive B-cell CD38+B220+ naive B-lymphocyte cell B220-positive CD38-positive naive B cell true A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery. cell B220-low CD38-positive naive B cell A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative. CD38- unswitched memory B cell CD38- unswitched memory B lymphocyte CD38- unswitched memory B-cell CD38- unswitched memory B-lymphocyte CD38-negative unswitched memory B lymphocyte CD38-negative unswitched memory B-cell CD38-negative unswitched memory B-lymphocyte cell CD38-negative unswitched memory B cell true An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative. cell B220-positive CD38-negative unswitched memory B cell true A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative. cell B220-low CD38-negative unswitched memory B cell A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative. CD38+ unswitched memory B cell CD38+ unswitched memory B lymphocyte CD38+ unswitched memory B-cell CD38+ unswitched memory B-lymphocyte CD38-positive unswitched memory B lymphocyte CD38-positive unswitched memory B-cell CD38-positive unswitched memory B-lymphocyte cell CD38-positive unswitched memory B cell true A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative. cell B220-positive CD38-positive unswitched memory B cell true A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative. cell B220-low CD38-positive unswitched memory B cell A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A class switched memory B cell that lacks IgG on the cell surface. IgG- class switched memory B cell IgG- class switched memory B lymphocyte IgG- class switched memory B-cell IgG- class switched memory B-lymphocyte IgG-negative class switched memory B lymphocyte IgG-negative class switched memory B-cell IgG-negative class switched memory B-lymphocyte cell IgG-negative class switched memory B cell true A class switched memory B cell that lacks IgG on the cell surface. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative. cell CD38-negative IgG-negative class switched memory B cell true A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative. cell CD38-positive IgG-negative class switched memory B cell true A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative. cell CD24-positive CD38-negative IgG-negative class switched memory B cell true An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative. cell CD24-negative CD38-negative IgG-negative class switched memory B cell true A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative. cell B220-positive CD38-positive IgG-negative class switched memory B cell true A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive. cell B220-low CD38-positive IgG-negative class switched memory B cell A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive. GOC:dsd GOC:rhs GOC:tfm PMID:20123131 A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma. tmeehan 2010-08-18T09:57:19Z gammadelta27-positive gd27-positive cell CD27-positive gamma-delta T cell true A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma. GOC:dsd GOC:tfm PMID:19270712 A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion. tmeehan 2010-08-18T09:57:29Z gammadelta-17 cells cell CD27-negative gamma-delta T cell true A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion. GOC:dsd GOC:tfm PMID:19270712 gammadelta-17 cells PMID:21976777 A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low). tmeehan 2010-08-18T10:35:37Z cell CD25-positive, CD27-positive immature gamma-delta T cell true A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low). GOC:tfm PMID:19270712 A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation. tmeehan 2010-08-20T02:14:25Z cell innate effector T cell true A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation. GOC:tfm PMID:20581831 A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg. Tc17 CD8+ T cell Tc17 T cell Tc17 T lymphocyte Tc17 T-cell Tc17 T-lymphocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition). Tc17 cell true A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg. GOC:add GOC:dsd GOC:tfm PMID:19201830 PMID:22343568 Tc17 CD8+ T cell PMID:22343568 Regular cardiac myocyte of a cardiac atrium. tmeehan 2010-08-23T11:41:03Z FMA:83108 atrial cardiac muscle cell atrial myocyte regular atrial cardiac muscle fiber regular cardiac muscle cell of atrium cell regular atrial cardiac myocyte Regular cardiac myocyte of a cardiac atrium. GOC:tfm atrial cardiac muscle cell GOC:pr A cardiac myocyte of the interatrial region of the heart. tmeehan 2010-08-23T11:41:09Z FMA:228790 cell regular interatrial cardiac myocyte A cardiac myocyte of the interatrial region of the heart. GOC:tfm Regular cardiac myocyte of a cardiac ventricle. tmeehan 2010-08-23T11:41:13Z ventricular cardiac muscle cell FMA:83109 regular cardiac muscle cell of ventricle regular ventricular cardiac muscle fiber ventricular myocyte cell regular ventricular cardiac myocyte Regular cardiac myocyte of a cardiac ventricle. GOC:tfm ventricular cardiac muscle cell GOC:pr A stomal cell of the ovary tmeehan 2010-08-23T12:10:31Z FMA:72299 ovarian stromal cell cell stromal cell of ovary A stomal cell of the ovary GOC:tfm ovarian stromal cell GOC:cjm A stromal cell of the ovarian cortex. tmeehan 2010-08-23T12:12:15Z FMA:256169 cell stromal cell of ovarian cortex A stromal cell of the ovarian cortex. GOC:tfm A stromal cell of the ovarian medulla. tmeehan 2010-08-23T12:12:17Z FMA:256171 cell stromal cell of ovarian medulla true A stromal cell of the ovarian medulla. GOC:tfm Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues. tmeehan 2010-08-24T08:43:27Z FMA:62880 cell nonkeratinized cell of epidermis Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues. GO:tfm PMID:1987287 A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol. tmeehan 2010-08-24T01:50:42Z FMA:69547 type II cortical cell of adrenal gland cell type II cell of adrenal cortex A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol. GOC:tfm ISBN:0517223651 A cell in the zona reticularis that produce sex hormones. tmeehan 2010-08-24T01:50:44Z FMA:69564 cell type III cell of adrenal cortex A cell in the zona reticularis that produce sex hormones. GOC:tfm ISBN:0517223651 A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions. tmeehan 2010-08-24T02:05:28Z CL:1000421 BTO:0004167 FMA:68458 LEC lymphatic endothelial cell cell endothelial cell of lymphatic vessel true A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions. GOC:tfm PMID:17846148 An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. tmeehan 2010-08-24T02:06:40Z BTO:0001854 CALOHA:TS-1106 FMA:67755 vascular endothelial cell cubodial endothelial cell of vascular tree cell These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. endothelial cell of vascular tree An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. GOC:dsd GOC:tfm PMID:12768659 A sebum secreting cell of the skin that secretes sebum into the hair follicles. tmeehan 2010-08-24T09:27:52Z CL:0002587 sebocyte BTO:0004613 FMA:70953 cell acinar cell of sebaceous gland true A sebum secreting cell of the skin that secretes sebum into the hair follicles. GOC:tfm A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1 tmeehan 2010-08-24T09:30:15Z FMA:69082 cell active chief cell of parathyroid gland A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1 FMA:0517223651 GOC:tfm A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus. tmeehan 2010-08-24T02:15:16Z FMA:70659 cell dark cell of eccrine sweat gland A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus. ISBN:0517223651 A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules. tmeehan 2010-08-24T02:18:36Z FMA:69080 cell dark chief cell of parathyroid cell A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules. GOC:tfm ISBN:0721662544 An endothelial cell found in capillaries. tmeehan 2010-08-24T10:15:00Z BTO:0004956 CALOHA:TS-0112 FMA:67756 cell capillary endothelial cell true An endothelial cell found in capillaries. GOC:tfm A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree. tmeehan 2010-08-24T03:38:29Z FMA:70542 cell ciliated columnar cell of tracheobronchial tree A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree. GOC:tfm ISBN:0517223651 A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin. tmeehan 2010-08-24T10:33:02Z FMA:70658 cell clear cell of eccrine sweat gland A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin. GOC:tfm ISBN:0517223651 A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells. tmeehan 2010-08-24T10:39:42Z FMA:69081 cell clear chief cell of parathyroid cell A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells. GOC:tfm ISBN:0618947256 A cell found within the dental pulp. tmeehan 2010-08-24T02:52:09Z BTO:0000339 CALOHA:TS-0195 FMA:87170 cell dental pulp cell A cell found within the dental pulp. GOC:tfm PMID:11087820 An epithelial cell of the uterus. tmeehan 2010-08-24T10:45:54Z CL:1000294 FMA:256161 cell epithelial cell of uterus true An epithelial cell of the uterus. GOC:tfm Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation. tmeehan 2010-08-24T03:48:30Z epithelioid cell FMA:83514 epithelioid histocyte epitheloid macrophage cell epithelioid macrophage Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation. MESH:A11.329.372.300 PMID:12673090 epithelioid histocyte MESH:A11.329.372.300 PMID:12673090 A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous. tmeehan 2010-08-24T03:07:50Z FMA:83534 cell late promyelocyte A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous. ISBN:0412046911 A columnar cell of the cervix uteri. tmeehan 2010-08-24T10:47:47Z FMA:86486 cell columnar cell of endocervix A columnar cell of the cervix uteri. GOC:tfm ISBN:0721662544 The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus. tmeehan 2010-08-24T10:53:03Z BTO:0001943 FMA:68650 cell corneocyte The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus. GOC:tfm ISBN:068340007X A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages. tmeehan 2010-08-24T03:07:53Z FMA:83533 cell early promyelocyte A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages. FMA:0412046911 GOC:tfm A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease. tmeehan 2010-08-24T03:15:21Z FMA:81099 burr cell cell echinocyte A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease. GOC:tfm A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones. tmeehan 2010-08-24T03:33:58Z FMA:86495 cell endosteal cell A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones. FMA:0618947256 GOC:tfm Epithelial cell found on the external side of the tympanic membrane tmeehan 2010-08-25T10:25:31Z FMA:70558 cell external epithelial cell of tympanic membrane Epithelial cell found on the external side of the tympanic membrane GOC:tfm PMID:5686391 Epithelial cells derived from general body ectoderm and ectoderm placodes. tmeehan 2010-08-26T08:31:08Z FMA:70556 cell general ecto-epithelial cell Epithelial cells derived from general body ectoderm and ectoderm placodes. GOC:tfm A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions. tmeehan 2010-08-25T10:28:44Z cell basal external epithelial cell of tympanic membrane A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions. PMID:5686391 A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus. tmeehan 2010-08-25T10:28:48Z cell superficial external epithelial cell of tympanic membrane A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus. PMID:5686391 An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones. tmeehan 2010-08-25T10:49:46Z FMA:70626 cell internal epithelial cell of tympanic membrane An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones. FMA:5686391 GOC:tfm A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells. tmeehan 2010-08-25T11:05:21Z FMA:75722 FMA:75726 cell internal pillar cell of cochlea A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells. GOC:tfm http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells. tmeehan 2010-08-25T11:05:23Z FMA:75727 cell external pillar cell of cochlea A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells. GOC:tfm http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html A supporting cell that is attached to the basement membrane and forms rows that support the hair cells. tmeehan 2010-08-25T01:29:07Z FMA:79800 cell phalangeal cell A supporting cell that is attached to the basement membrane and forms rows that support the hair cells. GOC:tfm ISBN:0618947256 An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth. tmeehan 2010-08-26T08:51:27Z FMA:62987 epithelial cell rests of Malassez epithelial debris of Malassez cell epithelial cell of Malassez true An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth. GOC:tfm ISBN:0517223651 ISBN:0815129521 A specialized cell involved in sensory perception of smell. tmeehan 2010-08-26T01:47:13Z FMA:67870 cell olfactory epithelial cell A specialized cell involved in sensory perception of smell. GOC:tfm PMID:7143026 A border cell is a slender columnar cell on the medial portion of the basilar membrane. tmeehan 2010-08-25T01:47:12Z FMA:79798 cell border cell of cochlea A border cell is a slender columnar cell on the medial portion of the basilar membrane. FMA:0412046911 GOC:tfm An epithelial cell located on the basal lamina of the olfactory epithelium. tmeehan 2010-08-26T01:58:54Z CL:1000395 horizontal basal call FMA:62303 cell basal cell of olfactory epithelium true An epithelial cell located on the basal lamina of the olfactory epithelium. GOC:tfm PMID:7143026 A keratinized cell located in the hard palate or gingiva. tmeehan 2010-08-26T02:51:30Z cell keratinized cell of the oral mucosa A keratinized cell located in the hard palate or gingiva. GOC:tfm PMID:12014572 A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium. tmeehan 2010-08-26T01:59:18Z FMA:67874 blastema cell of olfactory epithelium cell globose cell of olfactory epithelium A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium. GOC:tfm PMID:17468753 A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph. tmeehan 2010-08-25T02:02:48Z FMA:79797 interdental cell cell interdental cell of cochlea A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph. GOC:tfm MP:0004482 PMID:2111803 A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells. tmeehan 2010-08-25T02:20:55Z FMA:84143 KUPO:0001033 Goormaghtigh cell polar cushion cells cell lacis cell extraglomerular mesangial cell true A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells. GOC:tfm ISBN:0412046911 http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells A cell within the follicle of an ovary. tmeehan 2010-08-25T03:01:27Z EMAPA:31247 FMA:70589 cell follicular cell of ovary A cell within the follicle of an ovary. GOC:tfm A cell within the primary follicle of the ovary. tmeehan 2010-08-25T03:03:42Z FMA:70590 cell primary follicular cell of ovary A cell within the primary follicle of the ovary. GOC:tfm A cell of a secondary follicile within the ovary. tmeehan 2010-08-25T03:03:48Z FMA:70591 cell secondary follicular cell of ovary A cell of a secondary follicile within the ovary. GOC:tfm A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature. tmeehan 2010-08-25T03:10:10Z FMA:83102 folliculostellate cell of pars anterior of adenohypophysis cell folliculostellate cell of pars distalis of adenohypophysis true A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature. GOC:tfm An epithelial cell found in the lining of the stomach. tmeehan 2010-08-25T03:22:08Z CL:1000399 FMA:62948 cell epithelial cell of stomach true An epithelial cell found in the lining of the stomach. GOC:tfm An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop . tmeehan 2010-08-25T03:23:22Z FMA:86552 cell foveolar cell of stomach An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop . GOC:tfm http://www.merriam-webster.com/medical/foveolar A mucous cell in the epithelium of the stomach. tmeehan 2010-08-25T03:38:51Z CL:1000404 FMA:63464 cell mucous cell of stomach A mucous cell in the epithelium of the stomach. GOC:tfm A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach. tmeehan 2010-08-25T03:41:30Z CL:1000401 FMA:62954 cell mucus neck cell of gastric gland true true A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach. GOC:tfm ISBN:0517223651 A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall. tmeehan 2010-08-25T03:45:10Z FMA:62949 cell surface mucosal cell of stomach A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall. GOC:tfm ISBN:0517223651 A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. tmeehan 2010-08-25T03:57:08Z CL:1000400 FMA:62953 cell stem cell of gastric gland true A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. GOC:tfm ISBN:0517223651 A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium. tmeehan 2010-08-26T01:59:22Z FMA:62304 horizontal basal cells cell basal proper cell of olfactory epithelium A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium. GOC:tfm PMID:0517223651 PMID:11891623 A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane. tmeehan 2010-08-26T03:12:49Z CL:1000439 FMA:70571 cell basal cell of epidermis true A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane. GOC:tfm ISBN:0517223651 An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate. tmeehan 2010-08-26T10:59:44Z BTO:0004632 FMA:70970 cell glomerular endothelial cell true An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate. GOC:tfm PMID:15840009 A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules. tmeehan 2010-08-26T03:19:00Z FMA:70543 cell granular cell of epidermis A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules. ISBN:1416031855 A flat keratinocyte immediately below the cornified layer. tmeehan 2010-08-26T03:37:02Z FMA:86925 cell squamous cell of epidermis A flat keratinocyte immediately below the cornified layer. GOC:tfm ISBN:0517223651 A cell involved in the formation of a granulocyte. tmeehan 2010-08-30T12:54:27Z FMA:83519 cell granulocytopoietic cell true A cell involved in the formation of a granulocyte. GOC:tfm A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. tmeehan 2010-08-30T01:08:15Z FMA:83541 cell metamyelocyte A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. GOC:tfm ISBN:0721601464 http://en.wikipedia.org/wiki/Metamyelocyte A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses. tmeehan 2010-08-30T01:08:19Z BTO:0000734 FMA:83525 cell myelocyte A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses. GOC:tfm ISBN:0323052908 http://en.wikipedia.org/wiki/Myelocyte A cell involved in the formation of a monocyte (monopoiesis). tmeehan 2010-08-30T01:27:48Z FMA:83552 cell monopoietic cell true A cell involved in the formation of a monocyte (monopoiesis). GOC:tfm A stem cell that can give rise to the cells of the liver. tmeehan 2010-08-30T02:00:42Z FMA:86577 cell hepatic stem cell true A stem cell that can give rise to the cells of the liver. GOC:tfm A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue. tmeehan 2010-08-30T02:01:49Z CL:1000036 BTO:0004270 FMA:86576 hepatic oval cell cell hepatic oval stem cell A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue. PMID:17901986 A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1. tmeehan 2010-09-02T11:14:01Z cell inactive chief cell of parathyoid gland A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1. GOC:tfm ISBN:0517223651 A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands. tmeehan 2010-09-02T11:26:49Z FMA:67606 oxyphil cell oncocyte A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands. GOC:tfm ISBN:0721662544 PMID:20013317 An oncocyte located in the parathyroid gland. tmeehan 2010-09-02T11:33:23Z FMA:69084 cell oxyphil cell of parathyroid gland An oncocyte located in the parathyroid gland. PMID:20013317 An oncocyte located in the thyroid. tmeehan 2010-09-02T11:33:26Z FMA:87169 Askanazy cells Hurthle cells cell oxyphil cell of thyroid An oncocyte located in the thyroid. GOC:tfm PMID:20013317 A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance. tmeehan 2010-09-02T01:43:55Z cell renal beta-intercalated cell A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance. GOC:tfm PMID:11781354 An epithelial cell of the tracheobronchial tree. tmeehan 2010-09-02T02:09:14Z CL:1000407 FMA:66816 cell epithelial cell of tracheobronchial tree An epithelial cell of the tracheobronchial tree. GOC:tfm Brush cell found in the epithelial layer of the colon. tmeehan 2010-09-02T02:20:50Z CL:1000387 FMA:263222 cell Brush cells are a distinct cell type from brush border cell-types. Brush cell of epithelium proper of large intestine Brush cell found in the epithelial layer of the colon. GOC:tfm A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known. tmeehan 2010-09-02T02:28:53Z FMA:67978 caveolated cell fibrillovesicular cell multivesicular cell tuft cell cell brush cell A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known. GOC:tfm ISBN:0517223651 PMID:15817800 A brush cell found in the epithelium of lobular bronchiole. tmeehan 2010-09-02T02:38:34Z CL:1000386 FMA:263220 cell brush cell of lobular bronchiole A brush cell found in the epithelium of lobular bronchiole. GOC:tfm A brush cell of the epithelium in the terminal bronchiole. tmeehan 2010-09-02T02:38:36Z CL:1000390 FMA:263228 cell brush cell of terminal bronchiole A brush cell of the epithelium in the terminal bronchiole. GOC:tfm Brush cell of the epithelium in the trachea. tmeehan 2010-09-02T02:38:37Z CL:1000388 FMA:263224 cell brush cell of trachea true true Brush cell of the epithelium in the trachea. GOC:tfm A brush cell found in the epithelium of bronchus. tmeehan 2010-09-02T02:38:42Z CL:1000389 FMA:263226 cell brush cell of bronchus true true A brush cell found in the epithelium of bronchus. GOC:tfm An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells. tmeehan 2010-09-02T02:53:59Z FMA:69060 undifferentiated columnar cell of tracheobronchial tree cell intermediate epitheliocyte An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells. GOC:tfm ISBN:0517223651 A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance. tmeehan 2010-09-02T03:20:03Z FMA:84448 oxidative muscle fiber red muscle fiber cell red muscle cell A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance. GOC:tfm ISBN:0517223651 A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue. tmeehan 2010-09-02T03:24:05Z BTO:0001812 CALOHA:TS-0940 FMA:84413 MESH:A02.633.565.700 slow twitch fiber slow twitch muscle cell type 1 muscle cell type 1 muscle fiber type I muscle fiber cell intermediate muscle fiber slow twitch muscle fiber slow-twitch muscle fiber type I muscle cell A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue. GOC:tfm ISBN:0517223651 intermediate muscle fiber MESH:A02.633.565.700 slow twitch muscle fiber MESH:A02.633.565.700 slow-twitch muscle fiber MESH:A02.633.565.700 A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate. tmeehan 2010-09-02T03:28:45Z BTO:0001813 FMA:84414 type 2 muscle cell type 2 muscle fiber type II muscle fiber cell type II muscle cell A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate. GOC:tfm A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance. tmeehan 2010-09-02T03:28:48Z FMA:84449 cell white muscle cell A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance. GOC:tfm ISBN:0517223651 A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue. tmeehan 2010-09-02T03:31:38Z BTO:0001813 FMA:84415 fast twitch A fatigue resistant fast twitch muscle cell type 2a muscle cell type 2a muscle fiber type IIa muscle fiber cell type IIa muscle cell A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue. GOC:tfm A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity. tmeehan 2010-09-02T03:31:42Z FMA:84416 type 2b muscle cell type 2b muscle fiber type IIb muscle fiber cell type IIb muscle cell A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity. GOC:tfm ISBN:0517223651 http://en.wikipedia.org/wiki/Skeletal_muscle An intermediate muscle cell that has characteristics of both fast and slow muscle cells. tmeehan 2010-09-02T03:51:17Z FMA:84450 cell intermediate muscle cell An intermediate muscle cell that has characteristics of both fast and slow muscle cells. GOC:tfm A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus. tmeehan 2010-09-02T04:04:36Z BTO:0002366 FMA:86564 cell intermediate trophoblast cell A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus. GOC:tfm http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18. tmeehan 2010-10-07T01:58:00Z immature DEC precursor immature DETC precursor cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. immature dendritic epithelial T cell precursor A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18. GOC:tfm http://www.immgen.org A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua. tmeehan 2010-09-02T04:14:28Z cell anchoring trophoblast A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua. GOC:tfm http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html A cell located between the pinealocytes. tmeehan 2010-09-02T04:28:41Z FMA:86575 cell interstitial cell of pineal gland A cell located between the pinealocytes. GOC:tfm ISBN:0517223651 A squamous cell that has keratin in the esophagus. tmeehan 2010-09-07T10:11:06Z FMA:86549 cell keratinized squamous cell of esophagus A squamous cell that has keratin in the esophagus. GOC:tfm PMID:11694559 A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. tmeehan 2010-09-07T10:38:03Z FMA:70950 cell vertebrate lens cell A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. GOC:tfm ISBN:0721662544 A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s). tmeehan 2010-09-07T10:45:45Z FMA:63181 cell anterior lens cell A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s). GOC:tfm ISBN:0517223651 A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. tmeehan 2010-09-07T10:45:47Z FMA:67559 cell lens epithelial cell true A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. GOC:tfm ISBN:0721662544 http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded. tmeehan 2010-09-07T10:53:39Z secondary lens fibre cell secondary lens fiber A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded. GOC:tfm ISBN:0517223651 A secondary lens fiber cell that lacks a nucleus. tmeehan 2010-09-07T11:15:23Z FMA:67561 non-nucleated secondary lens fibre cell non-nucleated secondary lens fiber A secondary lens fiber cell that lacks a nucleus. GOC:tfm A secondary fiber cell that contains a nucleus. tmeehan 2010-09-07T11:15:26Z FMA:70949 nucleated secondary lens fibre cell nucleated secondary lens fiber A secondary fiber cell that contains a nucleus. GOC:tfm An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers. tmeehan 2010-09-07T11:19:01Z FMA:70613 primary lens fibre cell primary lens fiber An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers. GOC:tfm PMID:10711704 A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules. tmeehan 2010-09-07T11:46:54Z FMA:69079 cell light chief cell of parathyroid gland A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules. GOC:tfm ISBN:0721662544 An epithelial cell of the prostate. tmeehan 2010-09-07T01:49:29Z CL:1000295 CL:1000408 FMA:256163 FMA:66817 prostate epithelial cell cell epithelial cell of prostate true An epithelial cell of the prostate. GOC:tfm An epithelial cell of prostatic duct. tmeehan 2010-09-07T01:55:51Z CL:1000462 FMA:74224 ductal epithelial cell of prostate cell epithelial cell of prostatic duct true An epithelial cell of prostatic duct. GOC:tfm ductal epithelial cell of prostate FMA:74224 An epithelial cell of the prostatic acinus. tmeehan 2010-09-07T01:55:53Z CL:1000461 FMA:74223 acinar epithelial cell of prostate cell epithelial cell of prostatic acinus true An epithelial cell of the prostatic acinus. GOC:tfm PMCID:PMC2673349 acinar epithelial cell of prostate FMA:74223 A cell of the basal layer of the epithelium in the prostatic acinus. tmeehan 2010-09-07T01:59:08Z CL:1000464 FMA:74265 basal epithelial cell of prostatic acinus cell basal cell of prostatic acinus A cell of the basal layer of the epithelium in the prostatic acinus. GOC:tfm basal epithelial cell of prostatic acinus FMA:74265 A cell of the luminal layer of the epithelium in the prostatic acinus. tmeehan 2010-09-07T01:59:10Z FMA:74266 cell luminal cell of prostatic acinus A cell of the luminal layer of the epithelium in the prostatic acinus. GOC:tfm A cell that constitutes the basal layer of epithelium in the prostatic duct. tmeehan 2010-09-07T01:59:12Z CL:1000463 FMA:74226 cell basal epithelial cell of prostatic duct A cell that constitutes the basal layer of epithelium in the prostatic duct. GOC:tfm PMID:15226377 A cell that constitutes the luminal layer of epithelium of prostatic duct. tmeehan 2010-09-07T01:59:16Z FMA:74225 cell luminal epithelial cell of prostatic duct A cell that constitutes the luminal layer of epithelium of prostatic duct. GOC:tfm A primordial germ cell that is destined to become a male germ cell. tmeehan 2010-09-07T02:11:13Z EHDAA2:0001053 EMAPA:18686 FMA:84771 VHOG:0000662 male primordial germ cell testis primordial germ cell cell male gonocyte A primordial germ cell that is destined to become a male germ cell. GOC:tfm testis primordial germ cell VHOG:0000662 A primordial cell from which an oocyte (ovum) ultimately is developed. tmeehan 2010-09-07T02:11:16Z EHDAA2:0000505 EMAPA:17965 FMA:84772 ISBN:0721662544 VHOG:0000661 ovary primordial germ cell ovigerm cell ooblast A primordial cell from which an oocyte (ovum) ultimately is developed. GOC:tfm ovary primordial germ cell VHOG:0000661 ovigerm FMA:84772 A fibroblast in the bone marrow. tmeehan 2010-09-07T02:25:18Z FMA:84377 cell marrow fibroblast A fibroblast in the bone marrow. GOC:tfm A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis. tmeehan 2010-09-07T02:29:38Z FMA:84467 pulmonary myofibroblast pulmonary septal cell cell pulmonary interstitial fibroblast true A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis. GOC:tfm A cell containing at least one nucleus. tmeehan 2010-09-07T03:32:33Z FMA:67513 cell nucleate cell A cell containing at least one nucleus. GOC:tfm A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. tmeehan 2010-09-08T08:53:42Z FMA:70611 smooth muscle fiber of sphincter of pupil cell smooth muscle fibre of sphincter of pupil smooth muscle cell of sphincter of pupil true A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. GOC:tfm ISBN:0721662544 ISBN:0721694128 A nonstratified squamous cell located in the ectocervix. tmeehan 2010-09-08T09:12:23Z FMA:86483 ectocervical squamous cell cell squamous cell of ectocervix A nonstratified squamous cell located in the ectocervix. GOC:tfm http://www.bu.edu/histology/p/19404loa.htm OBSOLETE: A lymphocyte that lacks T or B cell surface markers. tmeehan 2010-09-07T03:43:42Z FMA:83601 cell obsolete null lymphocyte true OBSOLETE: A lymphocyte that lacks T or B cell surface markers. GOC:tfm ISBN:068340007X A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). tmeehan 2010-09-07T03:57:09Z BTO:0002669 FMA:86711 PBSC cell peripheral blood stem cell true A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). GOC:tfm A tissue macrophage that is in the pleural space. tmeehan 2010-09-07T04:16:43Z FMA:83024 cell pleural macrophage A tissue macrophage that is in the pleural space. GOC:tfm A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta. tmeehan 2010-09-07T04:26:06Z FMA:70570 cell pluripotent stem cell A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta. GOC:tfm PMID:19343304 A stem cell that can differentiate into a cardiac myocyte. tmeehan 2010-09-07T04:40:32Z FMA:75620 cell primitive cardiac myocyte A stem cell that can differentiate into a cardiac myocyte. GOC:tfm PMID:16938308 A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells. tmeehan 2010-09-08T09:21:22Z FMA:63379 stem cell of intestinal crypt of Lieberkuhn cell intestinal crypt stem cell A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells. GOC:tfm ISBN:0517223651 An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. tmeehan 2010-09-08T09:26:53Z cell epithelial cell of alimentary canal An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. GOC:tfm ISBN:0721662544 An epithelial cell of the esophagus. tmeehan 2010-09-08T09:28:20Z CL:1000402 FMA:63071 cell epithelial cell of esophagus true An epithelial cell of the esophagus. GOC:tfm An epithelial cell of the large intestine. tmeehan 2010-09-08T09:28:22Z CL:1000292 BTO:0004297 FMA:256157 cell epithelial cell of colon epithelial cell of large intestine true An epithelial cell of the large intestine. GOC:tfm An epithelial cell of the small intestine. tmeehan 2010-09-08T09:41:46Z CL:1000293 FMA:256159 cell epithelial cell of small intestine true An epithelial cell of the small intestine. GOC:tfm An epithelial cell that regulates growth and differentiation of the overlying epithelium. tmeehan 2010-09-08T09:50:04Z CALOHA:TS-1266 FMA:86490 cell stromal cell of endometrium true An epithelial cell that regulates growth and differentiation of the overlying epithelium. GOC:tfm PMID:11331626 A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings. tmeehan 2010-09-08T10:34:45Z FMA:84188 carotid body sustentacular cell cell supporting cell of carotid body A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings. GOC:tfm PMID:8985136 http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells An epithelial cell of thyroid gland. tmeehan 2010-09-08T01:46:51Z CL:1000297 FMA:256167 cell epithelial cell of thyroid gland true An epithelial cell of thyroid gland. GOC:tfm A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones. tmeehan 2010-09-08T01:50:08Z BTO:0003736 CALOHA:TS-1285 FMA:68782 follicular cell of thyroid gland principal cell of thyroid gland thyroid gland follicular cell cell thyroid follicular cell A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones. GOC:tfm ISBN:0517223651 The stem cell from which glial precursor cell arises from. tmeehan 2010-09-08T02:14:14Z FMA:87171 totipotent neuroepithelial stem cell cell neuroepithelial stem cell The stem cell from which glial precursor cell arises from. GOC:tfm PMID:11687496 An epithelial cell of the parathyroid gland. tmeehan 2010-09-08T02:29:38Z CL:1000429 FMA:70547 cell epithelial cell of parathyroid gland true An epithelial cell of the parathyroid gland. GOC:tfm An endothelial cell found in the mucosa associated with the facial skeleton. tmeehan 2010-09-14T10:40:12Z CL:1000446 FMA:70627 cell endothelial cell of viscerocranial mucosa An endothelial cell found in the mucosa associated with the facial skeleton. GOC:tfm ISBN:0618947256 An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. tmeehan 2010-09-14T10:57:26Z CL:1000403 FMA:63134 cell endothelial cell of sinusoid true An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. GOC:tfm ISBN:0618947256 One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage. tmeehan 2010-09-08T02:33:50Z FMA:69324 cell transitional cell of parathyroid gland One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage. GOC:tfm ISBN:0412046911 A type of enteroendocrine cell found in the stomach that secretes glucagon. tmeehan 2010-09-10T10:54:42Z FMA:83411 cell type A cell of stomach A type of enteroendocrine cell found in the stomach that secretes glucagon. GOC:tfm A D cell located in the colon. tmeehan 2010-09-10T11:37:35Z FMA:268744 colon D-cell colonc delta cell delta cell of colon cell type D cell of colon A D cell located in the colon. GOC:tfm A type D cell of the small intestine. tmeehan 2010-09-10T01:34:22Z FMA:268736 delta cell of small intestine small intestine D-cell small intestine delta cell cell type D cell of small intestine A type D cell of the small intestine. GOC:tfm A type D cell found in the stomach. tmeehan 2010-09-10T01:36:03Z FMA:83410 delta cell of stomach stomach D-cell stomach delta cell cell type D cell of stomach A type D cell found in the stomach. GOC:tfm An enteroendocrine cell that stores and secretes Ghrelin. tmeehan 2010-09-10T01:47:45Z FMA:63207 FMA:63418 cell P/D1 enteroendocrine cell An enteroendocrine cell that stores and secretes Ghrelin. GOC:tfm ISBN:0517223651 PMID:15153415 An endocrine cell that secretes vasoactive intestinal peptide. tmeehan 2010-09-10T01:52:20Z cell vasoactive intestinal peptide secreting cell An endocrine cell that secretes vasoactive intestinal peptide. GOC:tfm A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine. tmeehan 2010-09-10T02:13:47Z Mo enteroendocrine cell FMA:62941 cell type EC2 enteroendocrine cell A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine. GOC:tfm ISBN:0517223651 PMID:15153415 A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine. tmeehan 2010-09-10T02:13:49Z FMA:62940 cell type EC1 enteroendocrine cell A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine. GOC:tfm ISBN:0517223651 A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect. tmeehan 2010-09-10T02:31:13Z cell motilin secreting cell A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect. GOC:tfm MESH:D06.472.317.525 A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine. tmeehan 2010-09-10T02:35:17Z FMA:63208 cell type ECL enteroendocrine cell A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine. GOC:tfm ISBN:0517223651 PMID:15153415 A cell type that secretes histamine. tmeehan 2010-09-10T03:04:42Z cell histamine secreting cell A cell type that secretes histamine. GOC:tfm A PP cell located in the islets of the pancreas. tmeehan 2010-09-10T03:30:31Z BTO:0000805 FMA:70588 PP cell of pancreatic islet PP-cell of pancreatic islet pancreatic polypeptide-secreting cell cell The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. pancreatic PP cell A PP cell located in the islets of the pancreas. GOC:tfm OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus. tmeehan 2010-09-10T03:30:33Z FMA:85400 type F cell of pancreatic acinus cell obsolete PP cell of pancreatic acinus true OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus. GOC:tfm An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile. tmeehan 2010-09-10T03:44:36Z FMA:62937 CCK cell cell type I enteroendocrine cell An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile. GOC:tfm An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide. tmeehan 2010-09-10T03:51:47Z FMA:62942 type K enteroendocrine cell cell GIP cell An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide. GOC:tfm A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY. tmeehan 2010-09-10T03:59:09Z FMA:62944 cell type L enteroendocrine cell A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY. ISBN:0517223651 PMID:15153415 An enteroendorcine cell found in the ileum and jejunum that produces neurotensin. tmeehan 2010-09-10T04:08:29Z FMA:62943 N cell cell type N enteroendocrine cell An enteroendorcine cell found in the ileum and jejunum that produces neurotensin. GOC:tfm Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin. tmeehan 2010-09-10T04:44:46Z FMA:62936 cell type S enteroendocrine cell Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin. GOC:tfm PMID:15153415 An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide. tmeehan 2010-09-13T09:48:34Z FMA:63421 cell type TG enteroendocrine cell An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide. DOI:10.1007/978-3-211-99390-3 GOC:tfm PMID:7013499 An epithelial cell of the mucosa associated with facial skeleton. tmeehan 2010-09-14T11:04:02Z CL:1000440 FMA:70581 cell ecto-epithelial cell of viscerocranial mucosa An epithelial cell of the mucosa associated with facial skeleton. GOC:tfm ISBN:0323052908 An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin. tmeehan 2010-09-13T10:12:12Z FMA:63209 A-like X/A-like cell type X enteroendocrine cell An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin. GOC:tfm PMID:20616512 A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM. tmeehan 2010-09-13T10:57:21Z taste bud basal cell FMA:67940 type 3 taste cell cell type III taste bud cell A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM. GOC:tfm ISBN:0517223651 PMID:15738192 A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities. tmeehan 2010-09-13T10:57:26Z FMA:62381 type 2 taste cell cell type II taste cell A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities. GOC:tfm PMID:15738192 A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally. tmeehan 2010-09-13T10:57:29Z taste bud basal cell FMA:62380 type 4 taste cell cell There is debate about the exact lineage of these cell types from this progenitor. See PMID:15738192. type IV taste receptor cell A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally. GOC:tfm ISBN:0517223651 PMID:15738192 A cell type that forms the boundary with the surrounding epithelium. tmeehan 2010-09-13T10:57:31Z FMA:67941 cell type V taste receptor cell A cell type that forms the boundary with the surrounding epithelium. GOC:tfm ISBN:0517223651 A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST. tmeehan 2010-09-13T10:57:35Z FMA:62356 dark tongue cell type I taste cell type taste 1 cell cell type I taste bud cell A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST. GOC:tfm ISBN:0412046911 ISBN:0517223651 PMID:15738192 A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum. tmeehan 2010-09-13T11:35:24Z FMA:84058 Y bearing sperm Y-bearing sperm cell Y chromosome-bearing sperm cell A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum. GOC:tfm ISBN:0721669743 A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum. tmeehan 2010-09-13T11:35:26Z FMA:84057 X bearing sperm X-bearing sperm cell X chromosome-bearing sperm cell A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum. GOC:tfm ISBN:0721669743 A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters. tmeehan 2010-09-13T01:40:21Z FMA:84186 glomus cell cell type I cell of carotid body A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters. GOC:tfm ISBN:0517223651 An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies. tmeehan 2010-09-13T02:34:22Z CL:1000459 CALOHA:TS-1040 FMA:72208 epithelial cell of thymus gland epithelial reticular cell epithelial reticular cell of thymus thymic epithelial cell cell epithelial cell of thymus true An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies. FMA:72208 GOC:tfm An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule. tmeehan 2010-09-13T02:37:23Z FMA:72209 subcapsular thymic epithelial cell cell type-1 epithelial cell of thymus An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule. GOC:tfm PMID:9264335 A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections. tmeehan 2010-09-13T02:37:26Z FMA:72214 cystic thymic epithelial cells large mTEC large medullary thymic epithelial cells cell type-6 epithelial cell of thymus A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections. GOC:tfm PMID:19721455 PMID:9264335 An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus. tmeehan 2010-09-13T02:37:45Z FMA:72212 dark thymic epithelial cell cell type-4 epithelial cell of thymus An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus. FMA:0412046911 GOC:tfm PMID:9264335 A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex. tmeehan 2010-09-13T02:37:51Z FMA:72211 intermediate thymic epithelial cell cell type-3 epithelial cell of thymus A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex. PMID:9264335 A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla. tmeehan 2010-09-13T02:37:54Z FMA:72213 undifferentiated mTEC undifferentiated medullary thymic epithelial cell undifferentiated thymic epithelial cell cell type-5 epithelial cell of thymus A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla. GOC:tfm ISBN:0412046911 PMID:19721455 PMID:9264335 An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus. tmeehan 2010-09-13T02:37:58Z FMA:72210 pale thymic epithelial cell cell type-2 epithelial cell of thymus An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus. GOC:tfm ISBN:0412046911 PMID:9264335 A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin. tmeehan 2010-09-13T03:23:25Z spindle shaped mTEC spindle shaped medullary thymic epithelial cell cell type-7 epithelial cell of thymus A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin. GOC:tfm PMID:19721455 A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid. tmeehan 2010-09-13T03:39:14Z FMA:66788 cell type B synovial cell A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid. GOC:tfm ISBN:0517223651 A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum. tmeehan 2010-09-13T03:39:17Z FMA:66787 type A synoviocyte cell type A synovial cell A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum. GOC:tfm ISBN:0517223651 A ciliated epithelial cell of the retina, this cell type uptakes sodium chloride and passes it to non-pigmented ciliary epithelial cells. tmeehan 2010-09-13T04:09:27Z FMA:70606 PE cell pigmented ciliary epithelial cell A ciliated epithelial cell of the retina, this cell type uptakes sodium chloride and passes it to non-pigmented ciliary epithelial cells. PMID:15106942 A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells. tmeehan 2010-09-13T04:09:31Z FMA:70607 NPE cell non-pigmented ciliary epithelial cell A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells. GOC:tfm PMID:15106942 An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH. FMA:62125 FMA:70981 KUPO:0001055 kidney distal tubule epithelial cell cell epithelial cell of distal tubule true An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH. GOC:tfm ISBN:0517223651 An epithelial cell of the proximal tubule of the kidney. FMA:62125 FMA:70973 KUPO:0001044 kidney proximal tubule epithelial cell cell epithelial cell of proximal tubule true An epithelial cell of the proximal tubule of the kidney. GOC:tfm ISBN:1-4160-2328-3 A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow. tmeehan 2010-09-14T11:29:20Z cell brush border cell of the proximal tubule A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow. GOC:tfm ISBN:1-4160-2328-3 An epithelial cell of a skin gland. tmeehan 2010-09-14T12:00:07Z FMA:70657 epithelial cell of gland of skin cell epithelial cell of skin gland An epithelial cell of a skin gland. GOC:tfm A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells; tmeehan 2010-09-14T02:08:23Z BTO:0002509 FMA:83098 cell corticotroph A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells; GOC:tfm ISBN:0517223651 An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone. tmeehan 2010-09-14T02:25:34Z FMA:83097 cell mammosomatotroph An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone. GOC:tfm An acidophilic cell of the anterior pituitary that produces prolactin. tmeehan 2010-09-14T02:30:57Z FMA:83096 epsilon-acidophil lactotrope lactotroph lactotropic cell mammotrope mammotrophic cell mammotropic cell cell mammotroph An acidophilic cell of the anterior pituitary that produces prolactin. SANBI:mhl An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. tmeehan 2010-09-14T02:33:09Z FMA:83095 somatotrope somatotropic cell somatrophic cell cell somatotroph An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. SANBI:mhl An ecto-epithelial cell of the prostate gland that secretes hormones. tmeehan 2010-09-14T03:01:58Z CALOHA:TS-1280 FMA:74390 FMA:86774 glandular cell of prostate neuro-epithelial cell of prostate gland cell endocrine-paracrine cell of prostate gland An ecto-epithelial cell of the prostate gland that secretes hormones. GOC:tfm An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein. tmeehan 2010-09-14T03:20:01Z FMA:75809 cell external supporting cell of vestibular epithelium An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein. GOC:tfm PMID:20837532 An epithelial supporting cell located in the cochlea. tmeehan 2010-09-14T03:31:38Z FMA:79796 cell supporting cell of cochlea An epithelial supporting cell located in the cochlea. GOC:tfm A supporting cell of the vestibular epithelium. tmeehan 2010-09-14T03:31:44Z FMA:75607 cell supporting cell of vestibular epithelium A supporting cell of the vestibular epithelium. GOC:tfm PMID:20837532 An external limiting cell found in the vestibular epithelium. tmeehan 2010-09-14T03:33:50Z FMA:75808 cell external limiting cell of vestibular epithelium An external limiting cell found in the vestibular epithelium. GOC:tfm A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium. tmeehan 2010-09-15T10:47:11Z FMA:86712 cell periperhal blood mesothelial cell A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium. GOC:tfm PMID:14592528 A cell that is part of the nervous system. tmeehan 2010-09-15T01:34:57Z CALOHA:TS-2040 FMA:70333 cell neural cell A cell that is part of the nervous system. GOC:tfm ISBN:0618947256 A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. tmeehan 2010-09-15T03:01:54Z CL:1000406 CALOHA:TS-2096 FMA:63875 cell connective tissue cell true A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. GOC:tfm ISBN:0618947256 A cell of the embryo. tmeehan 2010-09-15T03:39:21Z CALOHA:TS-0263 FMA:82840 FMA:82841 WBbt:0007028 cell embryonic cell A cell of the embryo. FMA:0618947256 A stem cell of embryonic origin. tmeehan 2010-09-15T03:44:35Z BTO:0001086 CALOHA:TS-0263 FMA:82841 ESC cell This is an in vitro cell type and may be removed in future releases. These cells are reportedly SSEA-4-positive, CD73-negative, and CD324-positive. embryonic stem cell A stem cell of embryonic origin. GOC:dsd GOC:tfm ISBN:068340007X PMID:18179856 A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface. tmeehan 2010-09-20T10:13:37Z BTO:0000066 cell amniocyte true A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface. BFO:0000066 GOC:tfm PMID:3211847 A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative. tmeehan 2010-09-20T11:42:14Z cell myoepithelial cell of mammary gland A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative. GOC:tfm PMID:11250738 PMID:19022771 The milk-producing cell of the alveolar unit that emerges during pregnancy. tmeehan 2010-09-20T01:30:57Z CL:0002230 CL:1000476 FMA:74506 FMA:79866 epithelial cell of lactiferous gland luminal cell of alveolus of lactiferous gland cell mammary alveolar cell true The milk-producing cell of the alveolar unit that emerges during pregnancy. GOC:tfm PMID:19022771 A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast. tmeehan 2010-09-20T01:37:53Z FMA:73280 cell luminal epithelial cell of mammary gland A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast. GOC:tfm PMID:19022771 An epithelial cell of the mammary gland. tmeehan 2010-09-20T01:49:37Z BTO:0004300 breast epithelial cell mammary epithelial cell cell mammary gland epithelial cell An epithelial cell of the mammary gland. GOC:tfm PMID:19022771 An epithelial cell of the bronchus. tmeehan 2010-09-20T02:00:00Z BTO:0002922 cell bronchial epithelial cell An epithelial cell of the bronchus. GOC:tfm An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury. tmeehan 2010-09-20T02:10:36Z cell basal epithelial cell of tracheobronchial tree An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury. GOC:tfm An undifferentiated columnar cell of the bronchus epithelium tmeehan 2010-09-20T02:17:58Z cell undifferentiated cell of bronchus epithelium An undifferentiated columnar cell of the bronchus epithelium GOC:tfm PMID:18757316 A ciliated cell of the bronchus. tmeehan 2010-09-20T02:21:12Z cell ciliated cell of the bronchus A ciliated cell of the bronchus. GOC:tfm PMID:18757316 A fat cell derived from a neural crest cell. tmeehan 2010-09-20T02:25:25Z cell neural crest derived fat cell A fat cell derived from a neural crest cell. GOC:tfm PMID:17507398 An undifferentiated fibroblast that can be stimulated to form a fat cell. tmeehan 2010-09-20T02:31:53Z BTO:0001107 cell preadipocyte An undifferentiated fibroblast that can be stimulated to form a fat cell. GOC:tfm PMID:18793119 A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha). tmeehan 2010-09-20T02:38:38Z cell brown preadipocyte A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha). GOC:tfm PMID:18719589 An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek. tmeehan 2010-09-20T02:52:54Z cell buccal mucosa cell An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek. GOC:tfm MESH:A10.615.550.599 A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair. tmeehan 2010-09-20T03:07:03Z bulge keratinocyte cell keratinocyte stem cell A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair. PMID:15339667 A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive. tmeehan 2010-09-21T10:06:53Z cell p-NK Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). CD56-positive, CD161-positive immature natural killer cell true A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive. GOC:add GO_REF:0000031 ISBN:0781735149 PMID:12457618 p-NK PMID:12457618 A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium. tmeehan 2010-09-20T03:21:06Z CD133-positive prostate epithelial cell cell prostate stem cell A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium. GOC:tfm PMID:15226377 The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival. tmeehan 2010-09-20T03:34:05Z cell luminal cell of prostate epithelium The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival. GOC:tfm An undifferentiated cell of the prostate epithelium that lacks secretory activity. tmeehan 2010-09-20T03:34:10Z cell basal cell of prostate epithelium An undifferentiated cell of the prostate epithelium that lacks secretory activity. GOC:tfm PMCID:PMC2673349 A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage. tmeehan 2010-09-20T03:49:58Z cell circulating endothelial cell A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage. GOC:tfm PMID:19652886 A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy. tmeehan 2010-09-20T04:00:02Z dNK cell decidual NK cell cell decidual natural killer cell true A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy. PMID:14568979 PMID:19800965 A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive. tmeehan 2010-09-20T04:33:11Z cell p-NK Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). CD56-negative, CD161-positive immature natural killer cell true A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive. GOC:add GO_REF:0000031 ISBN:0781735149 PMID:12457618 p-NK PMID:12457618 An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver. tmeehan 2010-09-20T04:41:01Z preNK.BM cell Markers are associated with mouse cells. CD27-low, CD11b-low immature natural killer cell true An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver. GOC:tfm PMID:19949422 http:www.immgen.org/index_content.html An immature natural killer cell that is NK1.1-positive and DX-5 negative. tmeehan 2010-09-21T10:11:44Z cell Dx5-negative, NK1.1-positive immature natural killer cell true An immature natural killer cell that is NK1.1-positive and DX-5 negative. GOC:tfm PMID:12766763 A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion. tmeehan 2010-09-21T10:19:49Z cell CD27-high, CD11b-high natural killer cell A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion. GOC:tfm PMID:19949422 A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors. tmeehan 2010-09-21T10:19:54Z cell CD27-low, CD11b-high natural killer cell A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors. GOC:tfm PMID:1994922 A natural killer cell that is CD27-high and CD11b-low. tmeehan 2010-09-21T10:20:00Z cell CD27-high, CD11b-low natural killer cell A natural killer cell that is CD27-high and CD11b-low. GOC:tfm PMID:1994922 An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. tmeehan 2010-09-21T04:33:05Z CL:1000475 FMA:75621 endocardial endothelial cell endothelial cell of endocardium cell endocardial cell An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. GOC:tfm ISSN:0452-3458 endothelial cell of endocardium FMA:75621 A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. tmeehan 2010-09-21T04:41:06Z pancreatic endocrine progenitor pancreatic islet progenitor cell cell progenitor cell of endocrine pancreas A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. GOC:tfm PMID:20025937 PMID:20217494 A hematopoietic stem cell that exists during embryogenesis. tmeehan 2010-09-22T09:05:13Z cell gestational hematopoietic stem cell A hematopoietic stem cell that exists during embryogenesis. GOC:tfm ISBN:978-60327-246-6 A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative. tmeehan 2010-09-22T09:08:32Z cell fetal liver hematopoietic progenitor cell true A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative. GOC:tfm ISBN:978-1-60327-346-6 PMID:16569764 A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive. tmeehan 2010-09-22T09:08:34Z hemangioblast precursor cell yolk sac hematopoietic stem cell true A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive. GOC:tfm doi:10.1097/MOH.0b013e3282f97ae1 A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation. tmeehan 2010-09-22T09:27:05Z primitive erythroblast primitive erythrocyte primitive erythroid cell cell primitive red blood cell true A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation. DOI:10.1097/MOH.0b013e3282f97ae1 GOC:tfm PMID:11495698 A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains. tmeehan 2010-09-22T09:35:16Z megalocyte cell primitive reticulocyte true A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains. GOC:tfm PMID:11495698 doi:10.1097/MOH.0b013e3282f97ae1 A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins. tmeehan 2010-09-22T09:38:32Z macrocyte cell fetal derived definitive erythrocyte true A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins. GOC:tfm PMID:11495698 Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte. tmeehan 2010-09-22T10:02:37Z cell pyrenocyte true Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte. GOC:tfm A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells. tmeehan 2010-09-22T10:30:02Z cell placental hematopoietic stem cell A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells. GOC:tfm ISBN:978-1-60327-346-6 A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC. tmeehan 2010-09-22T10:31:49Z cell AGM hematopoietic stem cell A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC. GOC:tfm ISBN:978-1-60327-346-6 A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41. tmeehan 2010-09-22T10:47:28Z EryP-CFC inner blood island hemangioblast cell primitive erythroid progenitor true A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41. GOC:tfm ISBN:0813817986 PMID:20711979 A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive. tmeehan 2010-09-22T01:40:44Z cell granule cell precursor A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive. GOC:tfm PMID:14745007 A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate. tmeehan 2010-09-22T01:57:40Z corneal fibroblast corneal keratocyte cell keratocyte A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate. GOC:tfm ISBN:978-0-7020-2958-5 An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells. tmeehan 2010-09-23T03:17:12Z BTO:0004562 cTEC cell cortical thymic epithelial cell An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells. GOC:tfm PMID:18403190 An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output. tmeehan 2010-09-23T03:17:14Z BTO:0004563 mTEC cell medullary thymic epithelial cell An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output. GOC:tfm PMID:18180458 A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin. tmeehan 2010-09-23T03:46:34Z BTO:0004519 myometrium smooth muscle cell cell myometrial cell A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin. GOC:tfm PMID:11429640 A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure. tmeehan 2010-09-23T04:18:50Z trabeculocyte cell trabecular meshwork cell true A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure. GOC:tfm PMID:14500801 An endo-epithelial cell of the respiratory tract. tmeehan 2010-09-23T04:38:49Z BTO:0004533 airway epithelial cell cell respiratory epithelial cell true An endo-epithelial cell of the respiratory tract. GOC:tfm A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions. tmeehan 2010-10-01T09:02:42Z cell fungal spore A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions. FAO:0000019 GOC:tfm A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion. tmeehan 2010-09-23T04:42:27Z respiratory mucosa goblet cells cell respiratory goblet cell A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion. GOC:tfm ISBN:0721662544 respiratory mucosa goblet cells MP:0010863 A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell). tmeehan 2010-09-24T09:44:42Z BTO:0001268 FMA:72300 WBbt:0008378 cell somatic cell A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell). GOC:tfm ISBN:0721662544 A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. tmeehan 2010-09-24T01:13:01Z CL:0000369 myotubule single cell sarcomere cell myotube A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. GOC:dos GOC:tfm ISBN:0323052908 PMID:22274696 A peptide hormone secreting cell that secretes growth hormone releasing hormone. tmeehan 2010-09-24T01:36:44Z GHRH secreting cell somatocrinin secreting cell cell growth hormone releasing hormone secreting cell A peptide hormone secreting cell that secretes growth hormone releasing hormone. GOC:dph GOC:tfm A hair cell of the ear that contains the organs of balance and hearing. tmeehan 2010-09-24T01:49:31Z ear receptor cell cell ear hair cell A hair cell of the ear that contains the organs of balance and hearing. GOC:dph GOC:tfm ISBN:0192801023 A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19. tmeehan 2010-09-24T02:06:10Z Schwann cell precursor cell cell Schwann cell precursor A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19. GOC:tfm A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells. tmeehan 2010-09-24T02:10:26Z Schwann cell cell non-myelinating Schwann cell A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells. GOC:cvs GOC:tfm ISBN:0721662544 A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons. tmeehan 2010-09-24T02:10:31Z Schwann cell ZFA:0001725 cell immature Schwann cell A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons. GOC:cvs GOC:tfm ISBN:0721662544 A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive and is found in the fetal thymus. tmeehan 2010-10-07T02:21:07Z fetal Vgamma2+ thymocyte cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. immature Vgamma2-positive fetal thymocyte A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive and is found in the fetal thymus. GOC:tfm http://www.immgen.org A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood. tmeehan 2010-09-28T02:23:46Z FMA:86588 arachnoid cap cell cell meningothelial cell A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood. GOC:tfm http://www.aippg.net/forum/viewtopic.php?t=62590 An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere. tmeehan 2010-10-01T09:22:45Z FAO:0000039 cell oospore An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere. GOC:tfm ISBN:0851988857 SGD:clt A conidium that has only one nucleus. tmeehan 2010-10-01T09:26:39Z FAO:0000025 cell uninucleate conidium A conidium that has only one nucleus. GOC:tfm SGD:clt A conidium that has more than one nucleus. tmeehan 2010-10-01T09:31:28Z FAO:0000033 cell multinucleate conidium A conidium that has more than one nucleus. GOC:tfm SGD:clt A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head. FAO:0000033 cell conidium of conidiophore head A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head. GOC:tfm PMID:9529886 SGD:clt A macroconidium that has only one nucleus. FAO:0000029 cell uninucleate macroconidium A macroconidium that has only one nucleus. GOC:tfm SGD:clt An oblong or round asexual spore formed from conidial chains. BTO:0000127 FAO:0000042 cell blastospore blastoconidium An oblong or round asexual spore formed from conidial chains. GOC:tfm PMID:2524423 SGD:clt A macroconidium that has more than one nucleus. FAO:0000035 cell multinucleate macroconidium A macroconidium that has more than one nucleus. GOC:tfm SGD:clt Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores. FAO:0000041 cell arthrospore arthroconidium Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores. GOC:tfm PMID:2524423 SGD:clt An arthroconidium that has more than one nucleus. FAO:0000037 cell multinucleate arthroconidium An arthroconidium that has more than one nucleus. GOC:tfm SGD:clt An arthroconidium that has only one nucleus. FAO:0000031 cell uninucleate arthroconidium An arthroconidium that has only one nucleus. GOC:tfm SGD:clt A blastoconidium that has only one nucleus. FAO:0000030 cell uninucleate blastconidium A blastoconidium that has only one nucleus. GOC:tfm SGD:clt A blastoconidium that has more than one nucleus. FAO:0000036 cell multinucleate blastoconidium A blastoconidium that has more than one nucleus. GOC:tfm SGD:clt Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte. cell replaced_by: PO:0025017 obsolete plant spore true Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte. GOC:tfm PO:0025017 A monocyte that has characteristics of both patrolling and inflammatory monocytes. tmeehan 2010-10-04T10:52:03Z cell intermediate monocyte A monocyte that has characteristics of both patrolling and inflammatory monocytes. GOC:tfm PMID:20628149 PMID:20870168 A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta. tmeehan 2010-10-04T02:38:58Z cell Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs. CD141-positive myeloid dendritic cell true A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta. GOC:dsd GOC:tfm PMCID:PMC2882828 PMCID:PMC2882837 PMID:17332250 PMID:20628149 A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative. tmeehan 2010-10-04T11:26:18Z cell Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Gr1-high classical monocyte true A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative. GOC:tfm PMID:20628149 PMID:8890901 http://www.immgen.org/index_content.html A patrolling monocyte that is CD14-low and CD16-positive. tmeehan 2010-10-04T12:25:42Z non-classical monocyte, human cell Markers are associated with human monocytes. CD14-low, CD16-positive monocyte true A patrolling monocyte that is CD14-low and CD16-positive. GOC:tfm PMID:20870168 A CD14-positive monocyte that is also CD16-positive and CCR2-negative. tmeehan 2010-10-04T12:49:47Z CD16+ monocyte cell This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). CD14-positive, CD16-positive monocyte A CD14-positive monocyte that is also CD16-positive and CCR2-negative. GOC:tfm PMID:20628149 PMID:21937707 PMID:22343568 CD16+ monocyte PMID:22343568 An intermediate monocyte that is Gr1-positive, CD43-positive. tmeehan 2010-10-04T12:49:49Z cell Gr1-positive, CD43-positive monocyte An intermediate monocyte that is Gr1-positive, CD43-positive. GOC:tfm PMID:20628149 A myeloid dendritic cell found in the blood that is CD1c-positive. tmeehan 2010-10-04T02:39:01Z cell Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha. CD1c-positive myeloid dendritic cell true A myeloid dendritic cell found in the blood that is CD1c-positive. GOC:dsd GOC:tfm PMID:20204387 PMID:20628149 A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive. tmeehan 2010-10-05T10:11:38Z cell Fraction B/C precursor B cell true A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive. GOC:tfm http://www.immgen.org/index_content.html A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18. tmeehan 2010-10-07T02:05:46Z mature DEC precursor mature DETC precursor cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. mature dendritic epithelial T cell precursor A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18. GOC:tfm http://www.immgen.org/index_content.html A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative. tmeehan 2010-10-05T11:18:03Z Peyers patch B cell cell Peyer's patch B cell A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative. GOC:tfm http://www.immgen.org/index_content.html A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus. tmeehan 2010-10-07T02:24:36Z fetal Vgamma2-positive cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. mature Vgamma2-positive fetal thymocyte A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus. GOC:tfm http://www.immgen.org/index_content.html A thymocyte found in the fetal thymus. tmeehan 2010-10-07T02:28:25Z cell fetal thymocyte A thymocyte found in the fetal thymus. GOC:tfm A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative). tmeehan 2010-10-07T02:33:39Z gammadelta thymocyte gd thymocyte cell gamma-delta thymocyte A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative). GOC:tfm PMID:20725107 A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. tmeehan 2010-10-07T02:53:44Z Vgamma2-positive thymocyte cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. immature Vgamma2-positive thymocyte A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. GOC:tfm http://www.immgen.org A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus. tmeehan 2010-10-07T02:53:48Z Vgamma2-positive cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. mature Vgamma2-positive thymocyte A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus. GOC:tfm http://www.immgen.org/index_content.html A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. tmeehan 2010-10-07T02:59:05Z Vgamma2-negative thymocyte cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. immature Vgamma2-negative thymocyte A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. GOC:tfm http://www.immgen.org A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus. tmeehan 2010-10-07T02:59:08Z Vgamma2-negative cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. mature Vgamma2-negative thymocyte A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus. GOC:tfm http://www.immgen.org/index_content.html A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast. tmeehan 2010-11-10T09:40:33Z PaSC pancreas stellate cell cell pancreatic stellate cell A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast. GOC:mah GOC:tfm PMID:17200706 A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor. tmeehan 2010-10-07T03:07:44Z Vg1.1-positive, Vd6.3-negative T cell cell Vgamma1.1-positive, Vdelta6.3-negative thymocyte A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor. GOC:tfm http://www.immgen.org/index_content.html A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor. tmeehan 2010-10-07T03:03:00Z Vg1.1+Vd6.3+ T cell cell Vgamma1.1-positive, Vdelta6.3-positive thymocyte A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor. GOC:tfm http://www.immgen.org/index_content.html A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative. tmeehan 2010-10-07T03:10:32Z cell mature Vg1.1-positive, Vd6.3-negative T cell mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative. GOC:tfm http://www.immgen.org A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive. tmeehan 2010-10-07T03:10:35Z cell immature Vg1.1-positive, Vd6.3-negative T cell immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive. GOC:tfm http://www.immgen.org/index_content.html A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive. tmeehan 2010-10-07T03:10:39Z immature Vg1.1+Vd6.3+ T cell cell immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive. GOC:tfm http://www.immgen.org/index_content.html A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative. tmeehan 2010-10-07T03:10:41Z mature Vg1.1+Vd6.3+ T cell cell mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative. GOC:tfm http://www.immgen.org/index_content.html An immature or mature cell of the first erythroid lineage to arise during embryonic development. tmeehan 2010-10-12T11:22:41Z cell primitive erythroid lineage cell An immature or mature cell of the first erythroid lineage to arise during embryonic development. GOC:tfm A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells. tmeehan 2010-10-12T12:21:16Z cell hemangioblast A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells. GOC:tfm ISBN:0813817986 PMID:11495698 A T cell that expresses a T cell receptor complex and has completed T cell selection. tmeehan 2010-10-12T01:56:15Z CD3e-positive T cell mature T-cell cell CD3epsilon T cell mature T cell true A T cell that expresses a T cell receptor complex and has completed T cell selection. GOC:tfm A T cell that has not completed T cell selection. tmeehan 2010-10-12T01:56:17Z BTO:0001372 CALOHA:TS-1042 immature T-cell cell immature T cell true A T cell that has not completed T cell selection. GOC:tfm A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. tmeehan 2010-10-15T09:24:05Z cell nucleated reticulocyte true A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. GOC:tfm PMID:18182572 PMID:9011180 PMID:9046052 A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes. tmeehan 2010-10-15T09:24:08Z CALOHA:TS-0864 FMA:66785 cell enucleated reticulocyte true A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes. GOC:tfm ISBN:0-12203-052-4 ISBN:0721601464 A DN2 thymocyte that is Kit-hi. tmeehan 2010-10-21T10:12:05Z cell Observed in mice. DN2a thymocyte true A DN2 thymocyte that is Kit-hi. GOC:tfm PMID:20595614 A DN2 thymocyte that is Kit-low. tmeehan 2010-10-21T10:12:08Z cell Observed in mice. DN2b thymocyte true A DN2 thymocyte that is Kit-low. GOC:tfm PMID:20595614 A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive. tmeehan 2010-10-21T01:16:24Z ETP preT.ETP.Th cell ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative. early T lineage precursor true A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive. GOC:dsd GOC:tfm PMID:16551251 http://www.immgen.org/index_content.html A mature natural killer cell that is CD11b-positive and CD27-positive. tmeehan 2010-10-25T03:07:59Z cell A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive. CD11b-positive, CD27-positive natural killer cell true A mature natural killer cell that is CD11b-positive and CD27-positive. GOC:tfm http://www.immgen.org/index_content.html A double-positive, alpha-beta thymocyte that is small and not proliferating. tmeehan 2010-10-21T01:59:06Z T.DP.sm.Th cell resting double-positive thymocyte true A double-positive, alpha-beta thymocyte that is small and not proliferating. GOC:tfm http://www.immgen.org/index_content.html A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating. tmeehan 2010-10-21T01:59:11Z T.DPb.Th activated double-positive thymocyte cell double-positive blast true A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating. GOC:tfm http://www.immgen.org/index_content.html A double-positive thymocyte that is CD69-positive and has begun positive selection. tmeehan 2010-10-21T02:11:52Z T.DP69+.Th cell CD69-positive double-positive thymocyte true A double-positive thymocyte that is CD69-positive and has begun positive selection. GOC:tfm http://www.immgen.org/index_content.html A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor. tmeehan 2010-10-21T02:29:19Z T.4int8+.Th cell CD4-intermediate, CD8-positive double-positive thymocyte true A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor. GOC:tfm http://www.immgen.org/index_content.html A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor. tmeehan 2010-10-21T02:29:23Z T.4int8+.th cell CD4-positive, CD8-intermediate double-positive thymocyte true A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor. GOC:tfm http://www.immgen.org/index_content.html A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor. tmeehan 2010-10-21T02:43:52Z CD24-positive, CD4 single-positive semimature thymocyte T.4SP24int.Th cell Described in the immgene database as being CD24-intermediate. CD24-positive, CD4 single-positive thymocyte true A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor. GOC:tfm http://www.immgen.org/index_content.html A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive. tmeehan 2010-10-21T02:46:02Z T.4SP69+.Th intermediate CD4-single-positive cell CD69-positive, CD4-positive single-positive thymocyte true A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive. GOC:tfm http://www.immgen.org/index_content.html A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor. tmeehan 2010-10-21T02:59:10Z CD24-positive, CD8 single-positive semimature thymocyte T.8SP24int.Th cell Described in the immgene database as being CD24-intermediate. CD24-positive, CD8 single-positive thymocyte true A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor. GOC:tfm http://www.immgen.org/index_content.html A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive. tmeehan 2010-10-21T02:59:14Z T.8SP69+.Th intermediate CD8-single-positive cell CD69-positive, CD8-positive single-positive thymocyte true A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive. GOC:tfm http://www.immgen.org/index_content.html A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor. tmeehan 2010-10-21T03:31:19Z cell T.4SP24-.Th mature CD4 single-positive thymocyte true A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor. GOC:tfm http://www.immgen.org/index_content.html A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor. tmeehan 2010-10-21T03:51:50Z T.8SP24-.Th cell mature CD8 single-positive thymocyte true A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor. GOC:tfm http:www.immgen.org/index_content.html A mature NK cell that is NK1.1-positive. tmeehan 2010-10-25T03:18:04Z NK.sp NK1.1-positive NK cell cell Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice. NK1.1-positive natural killer cell true A mature NK cell that is NK1.1-positive. GOC:tfm A NK1.1-positive T cell that is NKGA2-positive. tmeehan 2010-10-25T03:31:09Z NK.G2A+.SP cell NKGA2-positive natural killer cell true A NK1.1-positive T cell that is NKGA2-positive. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is Ly49D-positive. tmeehan 2010-10-25T03:36:19Z NK.49D+.Sp cell Ly49D-positive natural killer cell true A NK1.1-positive T cell that is Ly49D-positive. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is CD94-positive. tmeehan 2010-10-25T03:36:28Z NK.94+.Sp cell CD94-positive natural killer cell true A NK1.1-positive T cell that is CD94-positive. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative. tmeehan 2010-10-25T03:56:21Z CD94- Ly49I-negative NK cell NK.49Cl-94-.Sp cell CD94-negative, Ly49CI-negative natural killer cell A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is Ly49Cl-positive. tmeehan 2010-10-25T03:36:38Z Ly49I-positive NK cell NK.49Cl+.Sp cell Ly49CI-positive natural killer cell true A NK1.1-positive T cell that is Ly49Cl-positive. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is Ly49H-positive. tmeehan 2010-10-25T03:36:43Z LyH49H-positive cell Ly49H-positive natural killer cell true A NK1.1-positive T cell that is Ly49H-positive. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is Ly49D-negative. tmeehan 2010-10-25T03:39:02Z NK.49D-.Sp cell Ly49D-negative natural killer cell true A NK1.1-positive T cell that is Ly49D-negative. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is Ly49Cl-negative. tmeehan 2010-10-25T03:52:04Z Ly49I-negative NK cell NK.49Cl-.Sp cell Ly49CI-negative natural killer cell true A NK1.1-positive T cell that is Ly49Cl-negative. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is CD94-negative. tmeehan 2010-10-25T03:54:18Z NK.94-.Sp cell CD94-negative natural killer cell true A NK1.1-positive T cell that is CD94-negative. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is Ly49H-negative. tmeehan 2010-10-25T03:42:42Z LyH49H-negative cell Ly49H-negative natural killer cell true A NK1.1-positive T cell that is Ly49H-negative. GOC:tfm http://www.immgen.org/index_content.html A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive. tmeehan 2010-10-25T03:56:27Z NK.49Cl+94+.Sp cell CD94-positive Ly49CI-positive natural killer cell A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive. GOC:tfm http://www.immgen.org/index_content.html A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place. tmeehan 2010-11-10T01:41:00Z cell tether cell A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place. GOC:cvs GOC:tfm PMID:9398434 A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi. tmeehan 2010-11-10T01:46:51Z cell mammary stem cell A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi. GOC:hjd GOC:tfm PMID:15987436 PMID:16397499 PMID:17851544 The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons. tmeehan 2010-11-10T02:51:34Z cell oligodendrocyte precursor cell true The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons. GOC:tfm PMID:20142420 Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive. tmeehan 2010-11-22T01:10:28Z DC.8-4-11b+ spleen double-negative dendritic cell cell Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell true Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive. GOC:tfm http://www.immgen.org/index_content.html A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive. tmeehan 2010-11-22T01:27:37Z DC.pDC.8- cell CD8_alpha-negative plasmactyoid dendritic cell true A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive. GOC:tfm http://www.immgen.org/index_content.html A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive. tmeehan 2010-11-22T01:23:07Z DC.pDC.8+ cell CD8_alpha-positive plasmactyoid dendritic cell true A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive. GOC:tfm http://www.immgen.org/index_content.html A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive. tmeehan 2010-11-22T03:57:57Z cell epidermal Langerhans cell true A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive. GOC:tfm http://www.immgen.org/index_content.html A dermal dendritic cell that is langerin-positive, CD103-positive, and CD11b-negative. tmeehan 2010-11-22T04:06:22Z cell langerin-positive dermal dendritic cell true A dermal dendritic cell that is langerin-positive, CD103-positive, and CD11b-negative. GOC:tfm http://www.immgen.org/index_content.html A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive. tmeehan 2010-11-22T04:09:44Z cell langerin-negative dermal dendritic cell true A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive. GOC:tfm http://www.immgen.org/index_content.html A conventional thymic dendritic cell that is CD8alpha-negative. tmeehan 2010-11-23T10:58:53Z DC.8-.Th cell CD8alpha-negative thymic conventional dendritic cell true A conventional thymic dendritic cell that is CD8alpha-negative. GOC:tfm PMID:19273629 http://www.immgen.org/index_content.html A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue. tmeehan 2010-11-23T01:32:43Z cell CD103-positive dendritic cell true A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue. GOC:tfm http://www.immgen.org/index_content.html A F4/80-negative dendritic cell located in adipose tissue. tmeehan 2010-11-23T01:38:21Z cell adipose dendritic cell true A F4/80-negative dendritic cell located in adipose tissue. GOC:tfm http://www.immgen.org/index_content.html An adipose dendritic cell that is SIRPa-positive. tmeehan 2010-11-23T01:40:44Z DC.SIRPa+.Ad cell SIRPa-positive adipose dendritic cell An adipose dendritic cell that is SIRPa-positive. GOC:tfm http://www.immgen.org/index_content.html An adipose dendritic cell that is SIRPa-negative. tmeehan 2010-11-23T01:40:46Z DC.SIRPa-.Ad cell SIRPa-negative adipose dendritic cell An adipose dendritic cell that is SIRPa-negative. GOC:tfm http://www.immgen.org/index_content.html A conventional dendritic cell that expresses CD11b (ITGAM). tmeehan 2010-11-23T01:50:05Z cell CD11b-positive dendritic cell true A conventional dendritic cell that expresses CD11b (ITGAM). GOC:tfm http://www.immgen.org/index_content.html A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative. tmeehan 2010-11-23T02:00:21Z DC.11cloSer.SI cell small intestine serosal dendritic cell true A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative. GOC:tfm http://www.immgen.org/index_content.html A myeloid suppressor cell that is Gr1-high and CD11c-negative. tmeehan 2010-11-23T02:15:12Z MDS.Gr1hi cell Gr1-high myeloid suppressor cell true A myeloid suppressor cell that is Gr1-high and CD11c-negative. GOC:tfm http://www.immgen.org/index_content.html A myeloid suppressor cell that is Gr1-low and CD11c-positive. tmeehan 2010-11-23T02:19:43Z MDS.Gr1lo cell Gr1-low myeloid suppressor cell true A myeloid suppressor cell that is Gr1-low and CD11c-positive. GOC:tfm http://www.immgen.org/index_content.html Gr1-high monocyte that lacks MHC-II receptor complex. tmeehan 2010-11-23T03:27:12Z Mo.6C+II- cell MHC-II-negative classical monocyte true Gr1-high monocyte that lacks MHC-II receptor complex. GOC:tfm http://www.immgen.org/index_content.html Gr1-high monocyte that has a MHC-II receptor complex. tmeehan 2010-11-23T03:30:21Z Mo.6c+II cell MHC-II-positive classical monocyte true Gr1-high monocyte that has a MHC-II receptor complex. GOC:tfm http://www.immgen.org/index_content.html Gr1-low non-classical monocyte that lacks expression of a MHC-II complex. tmeehan 2010-11-23T03:38:15Z Mo.6C-II- cell MHC-II-negative non-classical monocyte true Gr1-low non-classical monocyte that lacks expression of a MHC-II complex. GOC:tfm http://www.immgen.org/index_content.html Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex. tmeehan 2010-11-23T03:47:53Z Mo.6C-IIint cell MHC-II-low non-classical monocyte true Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex. GOC:tfm http://www.immgen.org/index_content.html Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex. tmeehan 2010-11-23T03:47:55Z Mo.6C-II+ cell MHC-II-high non-classical monocyte true Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex. GOC:tfm http://www.immgen.org/index_content.html A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high. tmeehan 2010-11-23T04:00:52Z cell lymphoid MHC-II-negative classical monocyte true A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high. GOC:tfm http://www.immgen.org/index_content.html A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high. tmeehan 2010-11-23T04:09:09Z cell lymphoid MHC-II-negative non-classical monocyte A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high. GOC:tfm http://www.immgen.org/index_content.html A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive. tmeehan 2010-11-23T04:19:25Z BTO:0004732 cell MF.BM bone marrow macrophage true A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive. GOC:tfm http://www.immgen.org/index_content.html A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive. tmeehan 2010-11-23T04:31:28Z cell adipose macrophage true A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive. GOC:tfm An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions. tmeehan 2010-11-23T04:40:50Z MF.Autofl.Ad cell F4/80-negative adipose macrophage true An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions. GOC:tfm http://www.immgen.org/index_content.html An adipose macrophage that does not express MHC-II but is F4/80-positive. tmeehan 2010-11-23T04:35:53Z MF.F480+.Ad cell F4/80-positive adipose macrophage true An adipose macrophage that does not express MHC-II but is F4/80-positive. GOC:tfm http://www.immgen.org/index_content.html A goblet cell located in the nasal epithelium. tmeehan 2010-12-03T03:03:02Z MP:0002262 cell nasal mucosa goblet cell A goblet cell located in the nasal epithelium. GOC:cjm GOC:tfm The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule. tmeehan 2010-12-03T03:11:48Z cell peritubular myoid cell true The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule. GOC:cjm GOC:tfm MP:0006420 A melanocyte that produces pigment in the dermis. tmeehan 2010-12-03T03:17:05Z cell dermal melanocyte A melanocyte that produces pigment in the dermis. GOC:cjm GOC:tfm MP:0009386 A melanocyte that produces pigment within the hair follicle. tmeehan 2010-12-03T03:17:09Z cell hair follicle melanocyte A melanocyte that produces pigment within the hair follicle. GOC:tfm MP:0004381 A melanocyte that produces pigment in the epithelium. tmeehan 2010-12-03T03:17:14Z cell The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium. epithelial melanocyte true A melanocyte that produces pigment in the epithelium. GOC:tfm MP:0009388 A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium. tmeehan 2010-12-03T03:25:32Z cell retinal melanocyte true A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium. GOC:tfm MP:0010190 A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) . tmeehan 2010-12-03T03:29:15Z cell strial intermediate cell A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) . GOC:tfm MP:0000048 A neuronal receptor that respond to mechanical pressure or distortion in the skin. tmeehan 2010-12-06T02:53:30Z cell cutaneous/subcutaneous mechanoreceptor cell A neuronal receptor that respond to mechanical pressure or distortion in the skin. GOC:tfm MP:0000973 A trophoblast cell that has a large volume of cytoplasm, is polyploidy and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta. tmeehan 2010-12-06T02:55:24Z giant trophoblast cell cell trophoblast giant cell true A trophoblast cell that has a large volume of cytoplasm, is polyploidy and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta. GOC:tfm MP:0001714 MP:19876834 A thymocyte that lacks expression of CD4 and CD8. tmeehan 2010-12-06T03:03:38Z double negative T cell cell double negative thymocyte true A thymocyte that lacks expression of CD4 and CD8. GOC:tfm MP:0002407 A supporting cell of the organ of Corti. tmeehan 2010-12-06T03:09:01Z cell organ of Corti supporting cell A supporting cell of the organ of Corti. GOC:tfm MP:0004300 A specialized cell involved in auditory sensory perception. tmeehan 2010-12-06T03:18:43Z cell auditory epithelial cell A specialized cell involved in auditory sensory perception. GOC:tfm A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria. tmeehan 2010-12-06T03:20:41Z cell strial marginal cell A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria. GOC:tfm MP:0004366 A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions. tmeehan 2010-12-06T03:26:53Z cell Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863] strial basal cell A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions. GOC:tfm MP:0004365 A cell located in the heart, including both muscle and non muscle cells. tmeehan 2010-12-07T09:37:22Z BTO:0001539 CALOHA:TS-0115 FMA:83808 FMA:84791 heart cell cell From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. cardiocyte true A cell located in the heart, including both muscle and non muscle cells. GOC:tfm A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte. tmeehan 2010-12-07T09:50:41Z embryonic cardiomyocyte neonatal cardiomyocyte cell fetal cardiomyocyte A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte. GOC:tfm MP:0008788 A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response. tmeehan 2010-12-07T09:54:50Z IEL intraepithelial T cell intraepithelial T-cell cell intraepithelial lymphocyte true A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response. GOC:tfm MP:0008894 A trophoblast giant cell derived from the mural trophectoderm. tmeehan 2010-12-07T10:07:47Z EMAPA:16066 cell primary trophoblast giant cell A trophoblast giant cell derived from the mural trophectoderm. GOC:tfm PMCID:PMC85124 A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast. tmeehan 2010-12-07T10:07:52Z cell secondary trophoblast giant cell A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast. GOC:tfm PMCID:PMC85124 A trophoblast cell that arises in the junctional zone (basal plate) of the placenta. tmeehan 2010-12-07T12:56:56Z cell spongiotrophoblast cell A trophoblast cell that arises in the junctional zone (basal plate) of the placenta. GOC:tfm MP:0008959 A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide. tmeehan 2010-12-07T03:42:06Z cell P enteroendocrine cell A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide. FMA:63418 GOC:tfm A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide. tmeehan 2010-12-07T03:42:09Z FMA:63207 cell type D1 enteroendocrine cell A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide. FMA:63207 GOC:tfm An enteroendocrine cell of the small intestine that secretes motilin. tmeehan 2010-12-07T03:55:49Z Mo enteroendocrine cell FMA:63420 cell type M enteroendocrine cell An enteroendocrine cell of the small intestine that secretes motilin. GOC:tfm PMID:15153415 A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc tmeehan 2010-12-07T04:03:56Z BTO:0002441 FMA:84639 cell adventitial cell A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc GOC:tfm A smooth muscle cell of the intestine. tmeehan 2011-01-17T03:39:38Z intestinal smooth muscle cell cell enteric smooth muscle cell true A smooth muscle cell of the intestine. GOC:tfm A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative. tmeehan 2011-01-21T01:27:41Z DC.103-11b+.Lv cell liver CD103-negative dendritic cell true A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative. GOC:tfm http:http://www.immgen.org/index_content.html A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver. tmeehan 2011-01-21T01:27:45Z DC.103+11b-.Lv cell liver CD103-positive dendritic cell true A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver. GOC:tfm http:http://www.immgen.org/index_content.html A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative. tmeehan 2011-01-21T01:57:00Z cell langerin-positive lymph node dendritic cell true A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative. GOC:tfm http://www.immgen.org/index_content.html A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative. tmeehan 2011-01-21T02:13:58Z cell langerin-negative, CD103-negative lymph node dendritic cell true A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative. GOC:tfm http://www.immgen.org/index_content.html A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low. tmeehan 2011-01-21T02:07:54Z cell CD103-positive, langerin-positive lymph node dendritic cell true A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low. GOC:tfm http://www.immgen.org/index_content.html A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high. tmeehan 2011-01-21T02:11:14Z cell CD103-negative, langerin-positive lymph node dendritic cell true A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high. GOC:tfm http://www.immgen.org/index_content.html A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low. tmeehan 2011-01-21T02:22:15Z cell CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell true A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low. GOC:tfm http://www.immgen.org/index_content.html A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high. tmeehan 2011-01-21T02:16:21Z cell CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell true A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high. GOC:tfm http://www.immgen.org/index_content.html A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment. tmeehan 2011-01-24T10:22:18Z tgd.vg5+.IEL cell Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment. GOC:tfm http://www.immgen.org/index_content.html A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment. tmeehan 2011-01-24T10:25:44Z tgd.vg5-.IEL cell Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment. GOC:tfm http://www.immgen.org/index_content.html An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane. tmeehan 2011-02-08T10:11:55Z interrenal noradrenaline type cell type n interrenal cell cell interrenal norepinephrine type cell An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane. GOC:MH GOC:tfm PMID:12668625 A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish. tmeehan 2011-02-08T10:21:35Z cell interrenal chromaffin cell A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish. GOC:MH GOC:tfm PMID:12668625 An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo. tmeehan 2011-02-08T10:27:05Z type a interrenal cell cell interrenal adrenaline secreting cell interrenal epinephrin secreting cell An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo. GOC:MH GOC:tfm PMID:12668625 An epithelial cell of the kidney. tmeehan 2011-02-08T10:46:34Z KUPO:0001019 cell kidney epithelial cell true An epithelial cell of the kidney. GOC:tfm KUPO:SJ An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type. tmeehan 2011-02-08T11:03:32Z cell interrenal epithelial cell An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type. GOC:mh GOC:tfm PMID:12668625 An insect excretory cell that regulates haemolymph composition by filtration and filtrate endocytosis. tmeehan 2011-02-08T01:34:56Z BTO:0004597 FMA:83807 cell nephrocyte An insect excretory cell that regulates haemolymph composition by filtration and filtrate endocytosis. GOC:tfm PMID:19783135 A fat cell that is part of subcutaneous adipose tissue. tmeehan 2011-02-21T02:51:22Z subcutaneous adipocyte cell subcutaneous fat cell true A fat cell that is part of subcutaneous adipose tissue. GOC:tfm A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both. tmeehan 2011-02-08T01:37:59Z cell renal filtration cell A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both. GOC:tfm A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the mesonephros tmeehan 2011-02-08T01:58:30Z cell mesonephric glomerular visceral epithelial cell A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the mesonephros GOC:tfm A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues. tmeehan 2011-02-08T02:07:33Z cell disseminated nephrocyte A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues. GOC:tfm PMID:19783135 A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the metanephros. tmeehan 2011-02-08T02:02:13Z cell metanephric glomerular visceral epithelial cell A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the metanephros. GOC:tfm A dermal dendritic cell that is CD1a-negative and CD14-positive. CD14+ dermal DC cell They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis. CD14-positive dermal dendritic cell true A dermal dendritic cell that is CD1a-negative and CD14-positive. GOC:dsd PMID:19236899 PMID:20309010 An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low. cell immature CD14-positive dermal dendritic cell true An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low. GOC:dsd A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive. cell mature CD14-positive dermal dendritic cell true A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:dsd A dermal dendritic cell that is CD1a-positive and CD14-negative. CD1a+ dermal DC cell Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse. CD1a-positive dermal dendritic cell true A dermal dendritic cell that is CD1a-positive and CD14-negative. GOC:dsd PMID:20309010 An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low. cell immature CD1a-positive dermal dendritic cell true An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low. GOC:dsd A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high. cell mature CD1a-positive dermal dendritic cell true A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high. GOC:dsd A myeloid dendritic cell found in the blood that is CD16-positive. CD16+ mDC CD16-mDC cell Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8). CD16-positive myeloid dendritic cell true A myeloid dendritic cell found in the blood that is CD16-positive. GOC:dsd PMID:17332250 An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low. cell immature CD16-positive myeloid dendritic cell true An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low. GOC:dsd A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high. cell mature CD16-positive myeloid dendritic cell true A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high. GOC:dsd An epithelial cell of the cervix. tmeehan 2011-02-24T08:20:08Z cervical canal epithelial cell cervical canal of uterus epithelial cell cervix epithelial cell cervix of uterus epithelial cell epithelial cell of cervical canal epithelial cell of cervical canal of uterus epithelial cell of cervix of uterus epithelial cell of neck of uterus epithelial cell of uterine cervix neck of uterus epithelial cell uterine cervix epithelial cell cell epithelial cell of cervix true An epithelial cell of the cervix. GOC:tfm cervical canal epithelial cell GOC:tfm cervical canal of uterus epithelial cell GOC:tfm cervix epithelial cell GOC:tfm cervix of uterus epithelial cell GOC:tfm epithelial cell of cervical canal GOC:tfm epithelial cell of cervical canal of uterus GOC:tfm epithelial cell of cervix of uterus GOC:tfm epithelial cell of neck of uterus GOC:tfm epithelial cell of uterine cervix GOC:tfm neck of uterus epithelial cell GOC:tfm uterine cervix epithelial cell GOC:tfm An epithelial cell that is part of the amnion. tmeehan 2011-02-28T12:38:01Z amniotic epithelial cell cell epithelial cell of amnion true true An epithelial cell that is part of the amnion. GOC:tfm A mesenchymal stem cell of the amnion membrane. tmeehan 2011-02-28T12:44:24Z amniotic membrane stem cell cell amnion mesenchymal stem cell A mesenchymal stem cell of the amnion membrane. GOC:tfm PMID:20446274 PMID:21339039 An epithelial cell of the intrahepatic portion of the bile duct. tmeehan 2011-02-28T01:20:20Z cell intrahepatic bile duct epithelial cell true An epithelial cell of the intrahepatic portion of the bile duct. GOC:tfm A smooth muscle cell of the aorta. tmeehan 2011-02-28T01:42:12Z BTO:0004577 cell aortic smooth muscle cell true A smooth muscle cell of the aorta. GOC:tfm A mesenchymal stem cell that is part of the bone marrow. tmeehan 2011-02-28T01:47:47Z cell mesenchymal stem cell of the bone marrow A mesenchymal stem cell that is part of the bone marrow. GOC:tfm A mesenchymal stem cell of the chorionic membrane. tmeehan 2011-02-28T03:04:35Z cell chorionic membrane mesenchymal stem cell A mesenchymal stem cell of the chorionic membrane. GOC:tfm An endothelial cell that is part of the vein. tmeehan 2011-02-28T03:48:11Z CL:1000393 FMA:62104 KUPO:0001099 endothelial cell of vein venous endothelial cell cell vein endothelial cell true An endothelial cell that is part of the vein. GOC:tfm An arterial endothelial cell that is part of the aorta endothelium. tmeehan 2011-02-28T03:54:42Z BTO:0003245 CALOHA:TS-0047 cell aortic endothelial cell An arterial endothelial cell that is part of the aorta endothelium. GOC:tfm An endothelial cell that is part of the thoracic endothelium. tmeehan 2011-02-28T03:59:09Z cell thoracic aorta endothelial cell true An endothelial cell that is part of the thoracic endothelium. GOC:tfm An endothelial progenitor cell that participates in angiogenesis during development. tmeehan 2011-02-28T04:20:39Z cell See CL:0002619. embryonic blood vessel endothelial progenitor cell An endothelial progenitor cell that participates in angiogenesis during development. GOC:tfm A fibroblast of the aortic adventitia. tmeehan 2011-02-28T04:43:41Z cell fibroblast of the aortic adventitia true A fibroblast of the aortic adventitia. GOC:tfm A fibroblast that is part of the heart. tmeehan 2011-02-28T04:57:44Z cardiac fibroblast cell fibroblast of cardiac tissue true true A fibroblast that is part of the heart. GOC:tfm A fibroblast that is part of the choroid plexus. tmeehan 2011-02-28T05:01:39Z cell fibroblast of choroid plexus true A fibroblast that is part of the choroid plexus. GOC:tfm A fibroblast that is part of the conjuctiva of the eye. tmeehan 2011-02-28T05:03:44Z cell fibroblast of the conjunctiva A fibroblast that is part of the conjuctiva of the eye. GOC:tfm tmeehan 2011-02-28T05:05:33Z cell fibroblast of dermis true tmeehan 2011-02-28T05:09:12Z cell fibroblast of gingiva true A fibroblast that is part of lung. tmeehan 2011-02-28T05:11:03Z BTO:0000764 CALOHA:TS-0575 cell fibroblast of lung true A fibroblast that is part of lung. GOC:tfm A fibroblast of the lymphatic system. tmeehan 2011-02-28T05:16:18Z cell fibroblast of lymphatic vessel true A fibroblast of the lymphatic system. GOC:tfm A fibroblast that is part of the mammary gland. tmeehan 2011-02-28T05:18:38Z cell fibroblast of mammary gland true A fibroblast that is part of the mammary gland. GOC:tfm A fibroblast of the periodontium. tmeehan 2011-02-28T05:19:48Z cell fibroblast of periodontium true A fibroblast of the periodontium. GOC:tfm A fibroblast of pulmonary artery. tmeehan 2011-02-28T05:22:27Z cell fibroblast of pulmonary artery true A fibroblast of pulmonary artery. GOC:tfm A fibroblast that is part of villous mesenchyme. tmeehan 2011-02-28T05:24:28Z cell fibroblast of villous mesenchyme A fibroblast that is part of villous mesenchyme. GOC:tfm An animal cell that is part of a hair follicle. tmeehan 2011-03-01T04:11:01Z cell hair follicle cell true An animal cell that is part of a hair follicle. GOC:tfm An epithelial cell that resides in the inner root sheath of the hair follicle. tmeehan 2011-03-01T04:27:51Z cell inner root sheath cell true An epithelial cell that resides in the inner root sheath of the hair follicle. GOC:tfm An epithelial cell that is part of the outer root sheath. tmeehan 2011-03-01T04:29:47Z cell outer root sheath cell true An epithelial cell that is part of the outer root sheath. GOC:tfm An epidermal cell that is part of the germinal matrix. tmeehan 2011-03-01T04:31:06Z trichocyte cell hair germinal matrix cell true An epidermal cell that is part of the germinal matrix. GOC:tfm An epithelial cell of the intestine. tmeehan 2011-03-01T05:18:31Z cell intestinal epithelial cell true An epithelial cell of the intestine. GOC:tfm A connective tissue cell of the nucleus pulposus cell of intervertebral disc. tmeehan 2011-03-02T02:12:23Z cell nucleus pulposus cell of intervertebral disc A connective tissue cell of the nucleus pulposus cell of intervertebral disc. GOC:tfm A pigment cell located in the epithelium of the iris. tmeehan 2011-03-01T05:28:52Z cell iris pigment epithelial cell true A pigment cell located in the epithelium of the iris. GOC:tfm A melanocyte that appears darker due to content or amount of melanin granules. tmeehan 2011-03-01T05:57:11Z cell dark melanocyte A melanocyte that appears darker due to content or amount of melanin granules. GOC:tfm A melanocyte that appears lighter in color. tmeehan 2011-03-01T05:58:23Z cell light melanocyte A melanocyte that appears lighter in color. GOC:tfm A mesenchymal stem cell that is part of Wharton's jelly. tmeehan 2011-03-01T09:51:18Z cell mesenchymal stem cell of Wharton's jelly A mesenchymal stem cell that is part of Wharton's jelly. GOC:tfm A mesenchymal stem cell of the umbilical cord. tmeehan 2011-03-01T09:55:12Z cell mesenchymal stem cell of umbilical cord A mesenchymal stem cell of the umbilical cord. GOC:tfm A mesenchymal stem cell of adipose tissue. tmeehan 2011-03-01T09:57:17Z cell mesenchymal stem cell of adipose A mesenchymal stem cell of adipose tissue. GOC:tfm A mesenchymal stem cell of liver. tmeehan 2011-03-01T09:58:51Z cell hepatic mesenchymal stem cell true A mesenchymal stem cell of liver. GOC:tfm A mesenchymal stem cell of the vertebrae. tmeehan 2011-03-01T10:40:27Z cell vertebral mesenchymal stem cell true A mesenchymal stem cell of the vertebrae. GOC:tfm A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function. tmeehan 2011-03-02T01:19:27Z BTO:0001220 CALOHA:TS-0898 cell Schwann cell true A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function. GOC:tfm A stromal cell of the pancreas. tmeehan 2011-03-02T02:40:41Z cell stromal cell of pancreas true A stromal cell of the pancreas. GOC:tfm A pericyte of the central nervous system. tmeehan 2011-03-02T02:54:18Z cell central nervous system pericyte true A pericyte of the central nervous system. GOC:tfm A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement. tmeehan 2011-03-02T03:03:58Z cell perineural cell true A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement. GO:tfm http://en.wikipedia.org/wiki/Perineurium An epithelial cell of the placenta. tmeehan 2011-03-02T03:21:30Z cell placental epithelial cell true An epithelial cell of the placenta. GOC:tfm A preadipocyte found in mesenteric tissue. tmeehan 2011-03-03T04:19:40Z cell mesenteric preadipocyte true A preadipocyte found in mesenteric tissue. GOC:tfm tmeehan 2011-03-03T04:19:42Z cell omentum preadipocyte true A preadipocyte that is part of the breast. tmeehan 2011-03-03T04:19:46Z cell preadipocyte of the breast true A preadipocyte that is part of the breast. GOC:tfm tmeehan 2011-03-03T04:20:04Z cell perirenal preadipocyte true A preadipocyte that is part of visceral tissue. tmeehan 2011-03-03T04:32:56Z cell visceral preadipocyte A preadipocyte that is part of visceral tissue. GOC:tfm A preadipocyte that is part of subcutaneous tissue. tmeehan 2011-03-03T04:33:01Z cell subcutaneous preadipocyte true A preadipocyte that is part of subcutaneous tissue. GOC:tfm An epithelial cell of the kidney cortex. KUPO:0001016 cell renal cortical epithelial cell true true An epithelial cell of the kidney cortex. GOC:tfm A blood vessel endothelial cell that is part of the retina. tmeehan 2011-03-06T03:28:27Z cell retinal blood vessel endothelial cell true A blood vessel endothelial cell that is part of the retina. GOC:tfm An epithelial cell of the retinal pigmented epithelium. tmeehan 2011-03-06T03:37:09Z BTO:0004910 FMA:75802 cell retinal pigment epithelial cell true An epithelial cell of the retinal pigmented epithelium. GOC:tfm A smooth muscle cell of the umbilical vein. tmeehan 2011-03-06T05:00:51Z cell smooth muscle cell of the umbilical vein true A smooth muscle cell of the umbilical vein. GOC:tfm A smooth muscle cell of the bachiocephalic vasculature. tmeehan 2011-03-06T05:00:58Z cell smooth muscle cell of the brachiocephalic vasculature true A smooth muscle cell of the bachiocephalic vasculature. GOC:tfm A vascular associated smooth muscle cell of the brain vasculature. tmeehan 2011-03-06T05:01:20Z cell smooth muscle cell of the brain vasculature true A vascular associated smooth muscle cell of the brain vasculature. GOC:tfm A smooth muscle of the pulmonary artery. tmeehan 2011-03-06T05:01:28Z BTO:0003336 cell smooth muscle cell of the pulmonary artery true A smooth muscle of the pulmonary artery. GOC:tfm A smooth muscle cell of the coronary artery. tmeehan 2011-03-06T05:01:34Z cell smooth muscle cell of the coronary artery true A smooth muscle cell of the coronary artery. GOC:tfm A smooth muscle of the internal thoracic artery. tmeehan 2011-03-06T05:01:41Z cell smooth muscle cell of the internal thoracic artery A smooth muscle of the internal thoracic artery. GOC:tfm A smooth muscle cell of the umbilical artery. tmeehan 2011-03-06T05:01:48Z cell smooth muscle cell of the umbilical artery true A smooth muscle cell of the umbilical artery. GOC:tfm A smooth muscle cell of the subclavian artery. tmeehan 2011-03-06T05:01:52Z cell smooth muscle cell of the subclavian artery true A smooth muscle cell of the subclavian artery. GOC:tfm Smooth muscle cell of the carotid artery. tmeehan 2011-03-06T05:01:56Z cell smooth muscle cell of the carotid artery true Smooth muscle cell of the carotid artery. GOC:tfm A smooth muscle cell of the bladder. tmeehan 2011-03-06T05:43:24Z KUPO:0001122 cell smooth muscle cell of bladder true A smooth muscle cell of the bladder. GC:tfm tmeehan 2011-03-06T05:46:39Z BTO:0004402 cell bronchial smooth muscle cell true A smooth muscle cell of the esophagus. tmeehan 2011-03-06T05:48:17Z cell smooth muscle cell of the esophagus true A smooth muscle cell of the esophagus. GOC:tfm A smooth muscle cell of the trachea. tmeehan 2011-03-06T05:50:28Z cell smooth muscle cell of trachea true A smooth muscle cell of the trachea. GOC:tfm A smooth muscle cell of the uterus. tmeehan 2011-03-06T05:53:28Z cell uterine smooth muscle cell true A smooth muscle cell of the uterus. GOC:tfm tmeehan 2011-03-06T06:50:53Z anulus pulposus cell cell annulus pulposus cell true An astrocyte of the cerebellum. tmeehan 2011-03-06T06:57:27Z cell astrocyte of the cerebellum true An astrocyte of the cerebellum. GOC:tfm tmeehan 2011-03-06T06:57:33Z cell astrocyte of the hippocampus An astrocyte of the cerebral cortex. tmeehan 2011-03-06T06:57:36Z cell astrocyte of the cerebral cortex An astrocyte of the cerebral cortex. GOC:tfm An astrocyte of the spinal cord. tmeehan 2011-03-06T07:11:26Z cell astrocyte of the spinal cord true An astrocyte of the spinal cord. GOC:tfm A neural crest cell that gives rise to cells of the enteric nervous system. tmeehan 2011-03-06T07:24:35Z cell migratory enteric neural crest cell A neural crest cell that gives rise to cells of the enteric nervous system. GOC:tfm A neuron of the hippocampus. tmeehan 2011-03-06T07:31:49Z cell hippocampal neuron A neuron of the hippocampus. GOC:tfm A CNS neuron of the cerebral cortex. tmeehan 2011-03-06T07:37:08Z BTO:0004102 FMA:84104 cortical neuron cell neuron of cerebral cortex A CNS neuron of the cerebral cortex. GOC:tfm A neuron of the raphe nuclei. tmeehan 2011-03-06T07:42:06Z cell raphe nuclei neuron true A neuron of the raphe nuclei. GOC:tfm A CNS neuron of the dorsal spinal cord. tmeehan 2011-03-06T07:43:34Z cell neuron of the dorsal spinal cord true A CNS neuron of the dorsal spinal cord. GOC:tfm A neuron of the ventral spinal cord. tmeehan 2011-03-06T07:46:03Z cell neuron of the ventral spinal cord true A neuron of the ventral spinal cord. GOC:tfm A neuron of the striatum. tmeehan 2011-03-06T07:47:12Z cell striatum neuron A neuron of the striatum. GOC:tfm A neuron of the substantia nigra. tmeehan 2011-03-06T07:48:42Z cell neuron of the substantia nigra true A neuron of the substantia nigra. GOC:tfm A fat cell that is part of omentum tissue. tmeehan 2011-03-14T10:17:00Z omental adipocyte omental fat cell cell adipocyte of omentum tissue true A fat cell that is part of omentum tissue. GOC:tfm A fat cell of perirenal fat tissue. tmeehan 2011-03-14T10:17:05Z perirenal fat cell cell perirenal adipocyte cell true A fat cell of perirenal fat tissue. GOC:tfm A fat cell that is part of the breast. tmeehan 2011-03-14T10:17:07Z CALOHA:TS-2377 breast adipocyte fat cell of breast cell Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA] adipocyte of breast true A fat cell that is part of the breast. GOC:tfm An endothelial cell of the umbilical vein. tmeehan 2011-03-14T11:36:51Z BTO:0004296 cell endothelial cell of umbilical vein An endothelial cell of the umbilical vein. GOC:tfm An adult angioblastic cell released from the bone marrow, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells. Their existence is controversial. tmeehan 2011-03-14T12:11:18Z EPC cell adult endothelial progenitor cell An adult angioblastic cell released from the bone marrow, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells. Their existence is controversial. GOC:tfm PMID:20807818 PMID:9020076 A fibroblast of skin. tmeehan 2011-03-14T12:31:49Z BTO:0001255 CALOHA:TS-0935 cell skin fibroblast true A fibroblast of skin. GOC:tfm tmeehan 2011-03-14T12:46:28Z cell gingival epithelial cell A stromal cell of the prostate. tmeehan 2011-03-14T02:11:10Z BTO:0003972 cell prostate stromal cell true A stromal cell of the prostate. GOC:tfm An acinar cell of salivary gland. tmeehan 2011-03-14T02:22:22Z cell acinar cell of salivary gland true An acinar cell of salivary gland. GOC:tfm A paneth cell of the appendix. tmeehan 2011-03-15T09:38:18Z cell paneth cell of the appendix true A paneth cell of the appendix. GOC:tfm A cell of the seminiferous tubule epithelium. tmeehan 2011-03-15T11:59:23Z cell seminiferous tubule epithelial cell true A cell of the seminiferous tubule epithelium. GOC:tfm An immature astrocyte. immature astrocytic glia cell immature astrocyte An immature astrocyte. GOC:dsd A mature astrocyte that is capable of producing cytokines. activated astrocyte mature astrocytic glia cell Mature astrocytes are reportedly able to produce aspartate, ATP, BDNF, BMP-2a, BMP-3, CCL2, CCL3, CCL4, CCL5, CCL19, CCL20,CD40L, CNTF, CTGF, CXCL1, CXCL2, CXCL8, edn-1, aFGF, bFGF, G-CSF, glutamate, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, IGF-1, IL-1alpha, IL-1beta, IL-2, Il-4, IL-6, IL-10, IL-12, LIF, MIP-2, NGF, nitric oxide, NT3, taurine, TGF-beta, TNF-alpha, TNF-beta. mature astrocyte A mature astrocyte that is capable of producing cytokines. GOC:dsd PMID:12898703 PMID:8734446 An immature microglial cell with a ramified morphology. immature microglia quiescent microglia resting microglia cell Immature microglia are reportedly CD34-positive, CD163-negative, MHCI-negative, MHCII-negative. immature microglial cell An immature microglial cell with a ramified morphology. GOC:dsd PMID:18396103 PMID:19461673 quiescent microglia PMID:18396103 resting microglia PMID:18396103 A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation. activated microglia mature microglia reactive microglia cell Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha. mature microglial cell true A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation. GOC:dsd PMID:11517395 PMID:14612429 PMID:15246020 PMID:16177057 PMID:18396103 PMID:20021364 activated microglia PMID:18396103 reactive microglia PMID:18396103 A spore formed from bacteria in the order Actinomycetales. tmeehan 2011-06-16T01:01:41Z cell actinomycete-type spore A spore formed from bacteria in the order Actinomycetales. GO:0034304 GOC:tfm tmeehan 2011-06-21T12:28:55Z cell epithelial cell of upper respiratory tract true tmeehan 2011-06-21T12:29:31Z cell epithelial cell of lower respiratory tract true A basal cell in the respiratory tract. tmeehan 2011-06-21T03:11:10Z airway basal cell airway basal stem cell cell respiratory basal cell A basal cell in the respiratory tract. GOC:tfm PMID:20699479 An epithelial cell of the anal column. tmeehan 2011-07-08T12:11:38Z cell epithelial cell of anal column An epithelial cell of the anal column. GOC:tfm A nonkeratinized epithelial cell of the anal canal. tmeehan 2011-07-08T02:05:33Z FMA:263146 cell nonkeratinized epithelial cell of anal column A nonkeratinized epithelial cell of the anal canal. GOC:tfm A nonkeratinized cell epithleial cell of the inferior part of the anal canal. tmeehan 2011-07-08T02:06:53Z FMA:263144 cell nonkeratinized epithelial cell of inferior part of anal canal A nonkeratinized cell epithleial cell of the inferior part of the anal canal. GOC:tfm An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal. tmeehan 2011-07-08T02:08:40Z cell keratinized epithelial cell of the anal canal An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal. GOC:tfm A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and Clara cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc. tmeehan 2011-06-21T03:26:08Z BASC basal epithelial cell of bronchioalveolar duct junction cell bronchioalveolar stem cell A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and Clara cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc. GOC:tfm PMID:15960971 An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone tmeehan 2011-06-21T03:55:39Z cell Not clear to me if amniotic stem cell is a different cell type from amnion mesenchymal stem cells. They are treated as distinct in the literature as isolations methods are different, so I will keep them as separate terms for now. amniotic stem cell An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone GOC:tfm PMID:20942606 An epithelial fate stem cell derived form the amnion membrane. tmeehan 2011-06-21T04:06:17Z cell amniotic epithelial stem cell An epithelial fate stem cell derived form the amnion membrane. GOC:tfm PMID:20446274 An epithelial cell of the esophageal gland proper. tmeehan 2011-07-08T02:16:51Z FMA:256141 cell epithelial cell of esophageal gland proper An epithelial cell of the esophageal gland proper. GOC:tfm An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia. tmeehan 2011-07-08T02:16:54Z FMA:256143 cell epithelial cell of esophageal cardiac gland An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia. GOC:tfm http://web.mac.com/wjkrause/iWeb/Histology/Blog/E3FA5916-1AA9-4885-B579-5051838D98CB.html An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin. tmeehan 2011-07-08T02:22:09Z FMA:263148 cell nonkeratinized cell of stratum corneum of esophageal epithelium An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin. GOC:tfm An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa. tmeehan 2011-07-08T02:25:44Z FMA:70628 cell endo-epithelial cell of tympanic part of viscerocranial mucosa An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa. GOC:tfm An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa. tmeehan 2011-07-08T02:25:46Z FMA:70629 cell endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa. GOC:tfm An ecto-epithelial cell of the buccal region of the viscerocranial mucosa. tmeehan 2011-07-08T02:34:12Z FMA:70577 cell obsolete epithelial cell of buccal part of viscerocranial mucosa true An ecto-epithelial cell of the buccal region of the viscerocranial mucosa. GOC:tfm An ecto-epithelial cell of the palatal region of the viscerocranial mucosa. tmeehan 2011-07-08T02:34:14Z FMA:70580 cell obsolete epithelial cell of anterior palatal part of viscerocranial mucosa true An ecto-epithelial cell of the palatal region of the viscerocranial mucosa. GOC:tfm An ecto-epithelial cell of the nasal region of the viscerocranial mucosa. tmeehan 2011-07-08T02:36:06Z FMA:70554 cell obsolete epithelial cell of nasal part of viscerocranial mucosa true An ecto-epithelial cell of the nasal region of the viscerocranial mucosa. GOC:tfm An ecto-epithelial cell of the gingival region of the viscerocranial mucosa. tmeehan 2011-07-08T02:36:11Z FMA:70579 cell obsolete epithelial cell of gingival part of viscerocranial mucosa true An ecto-epithelial cell of the gingival region of the viscerocranial mucosa. GOC:tfm An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa. tmeehan 2011-07-08T02:38:18Z FMA:70578 cell obsolete epithelial cell of paranasal sinus part of viscerocranial mucosa true An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa. GOC:tfm An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits. tmeehan 2011-07-08T03:06:49Z FMA:72140 stave cell cell endothelial cell of venous sinus of spleen An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits. GOC:tfm stave cell FMA:62817 A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream. tmeehan 2011-07-08T03:14:10Z FMA:67759 HEV cell endothelial cell of postcapillary venule of lymph node cell Markers expressed on HEV include: MAdCAM-1,PNAd (sulfated and glycosylated molecules, i.e. GlyCAM-1, CD34, endomucin, nepmucin), ICAM-1, ICAM-2,Fuc-TVII, beta 3GlcNAcT-3, GlcNAc6ST2,CCL21, CCL19, CXCL13, CXCL12, Autotaxin, DARC, angiomodulin, LRHG. endothelial cell of high endothelial venule A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream. GOC:tfm PMID:20726857 A endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells. tmeehan 2011-07-08T03:31:25Z cell squamous endothelial cell A endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells. GOC:tfm An epithelial cell of stratum corneum of esophageal epithelium. tmeehan 2011-07-08T03:46:35Z FMA:70733 cell epithelial cell of stratum corneum of esophageal epithelium An epithelial cell of stratum corneum of esophageal epithelium. GOC:tfm An epithelial cell of stratum spinosum of esophageal epithelium. tmeehan 2011-07-08T03:48:26Z FMA:70732 cell epithelial cell of stratum spinosum of esophageal epithelium An epithelial cell of stratum spinosum of esophageal epithelium. GOC:tfm A glandular epithelial cell of the endometrium. tmeehan 2011-07-08T03:54:08Z FMA:86489 cell glandular cell of endometrium A glandular epithelial cell of the endometrium. GOC:tfm A glandular epithelial cell of the esophagus. tmeehan 2011-07-08T03:55:57Z FMA:86548 cell glandular cell of esophagus true true A glandular epithelial cell of the esophagus. GOC:tfm A glandular epithelial cell of the large intestine. tmeehan 2011-07-08T04:03:01Z FMA:87194 cell glandular cell of the large intestine true A glandular epithelial cell of the large intestine. GOC:tfm A glandular epithelial cell that is part of the stomach. tmeehan 2011-07-11T01:20:35Z CALOHA:TS-1284 FMA:86554 cell glandular cell of stomach true A glandular epithelial cell that is part of the stomach. GOC:tfm A luminal epithelial cell of mammary gland located in acinus of structure. tmeehan 2011-07-11T01:44:31Z FMA:74505 cell Consider if synonymous with mammary alveolar cell CL:0002325. Some use this term to refer to the non-lactating cell type that gives rise to the lactating cell type. luminal cell of acinus of lactiferous gland A luminal epithelial cell of mammary gland located in acinus of structure. GOC:tfm A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into. tmeehan 2011-07-11T01:44:33Z FMA:87168 cell luminal cell of lactiferous terminal ductal lobular unit A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into. GOC:tfm A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive. tmeehan 2011-07-11T01:44:48Z FMA:74504 FMA:74505 cell luminal cell of lactiferous duct A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive. GOC:tfm PMID:19022771 A myocardial endocrine cell that is part of the atrium. tmeehan 2011-07-11T02:45:39Z FMA:83389 cell myocardial endocrine cell of atrium true A myocardial endocrine cell that is part of the atrium. GOC:tfm A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. tmeehan 2011-07-11T03:15:38Z cell Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. cardioblast A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. GOC:tfm PMID:19745164 A fibrocyte of the cochlea that has specialized structural and molecular adaptions. tmeehan 2011-07-11T03:35:01Z cell otic fibrocyte A fibrocyte of the cochlea that has specialized structural and molecular adaptions. GOC:tfm PMID:18353863 An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. tmeehan 2011-07-11T03:40:40Z type II otic fibrocyte type II spiral ligament fibrocyte cell type 2 otic fibrocyte An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. GOC:tfm PMID:18353863 type II spiral ligament fibrocyte MP:0004488 An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. tmeehan 2011-07-11T03:40:42Z type V otic fibrocyte type V spiral ligament fibrocyte cell type 5 otic fibrocyte An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. GOC:tfm PMID:18353863 An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall. tmeehan 2011-07-11T03:40:46Z type IV otic fibrocyte type IV spiral ligament fibrocyte cell type 4 otic fibrocyte An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall. GOC:tfm PMID:18353863 type IV spiral ligament fibrocyte MP:0004490 An otic fibrocyte that lines the otic capsule. tmeehan 2011-07-11T03:40:50Z type III otic fibrocyte type III spiral ligament fibrocyte cell type 3 otic fibrocyte An otic fibrocyte that lines the otic capsule. GOC:tfm PMID:18353863 type III spiral ligament fibrocyte MP:0004489 An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. tmeehan 2011-07-11T03:39:27Z type I otic fibrocyte type I spiral ligament fibrocyte cell type 1 otic fibrocyte An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. GOC:tfm PMID:18353863 type I spiral ligament fibrocyte MP:0004487 An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout. tmeehan 2011-08-16T01:49:32Z cell endothelial stalk cell An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout. GOC:tfm PMID:21521739 A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. tmeehan 2011-08-16T02:38:01Z cell retinal progenitor cell A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. GOC:tfm PMID:20959166 PMID:21148186 A skeletal muscle cell that is part of the tongue. tmeehan 2011-08-16T03:10:02Z cell tongue muscle cell A skeletal muscle cell that is part of the tongue. GOC:tfm PMID:18816858 A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus. tmeehan 2011-08-16T03:20:53Z H- cell cell H minus A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus. GOC:tfm A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus. tmeehan 2011-08-16T03:20:58Z cell H plus A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus. GOC:tfm A neuroblast derived from a neural crest cell. tmeehan 2011-08-22T09:24:15Z cell neural crest derived neuroblast A neuroblast derived from a neural crest cell. GOC:tfm PMID:17407019 A regulatory T cell that has not encountered antigen. tmeehan 2011-08-25T03:17:21Z naive regulatory T lymphocyte naive regulatory T-cell naive regulatory T-lymphocyte cell This cell type has been described as CD45RA-negative, but this doesn't fit with our current definition of naive T cell. naive regulatory T cell A regulatory T cell that has not encountered antigen. GOC:tfm A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen. tmeehan 2011-08-25T03:17:34Z cell Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell. memory regulatory T cell A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen. GOC:tfm PMID:21739668 A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13 tmeehan 2011-08-29T10:08:02Z cell natural helper lymphocyte true A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13 GOC:tfm PMID:20023630 A PP cell found in intestine. tmeehan 2011-09-27T11:59:01Z cell PP cell of intestine true A PP cell found in intestine. GOC:tfm PMID:2420136 PMID:728970 terryh 2011-10-25T03:49:41Z cell kidney cortical cell true A CNS interneuron located in the spinal cord. cell Is_a interneuron, part_of UBERON:0002240. spinal cord interneuron true A CNS interneuron located in the spinal cord. CL:CVS A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore. cell Derived from UBERON:0002342 neural crest. iridoblast A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore. CL:CVS A non-terminally differentiated cell that differentiates into a xanthophore. cell xanthoblast A non-terminally differentiated cell that differentiates into a xanthophore. CL:CVS A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore. cell leucoblast A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore. CL:CVS A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore. cell pigment erythroblast A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore. CL:CVS A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore. cell cyanoblast A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore. CL:CVS Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment. cell ionocyte Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment. PMID:17555741 PMID:19268451 Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons. KA cell KA interneuron KA neuron Kolmer-Agduhr cell cell Kolmer-Agduhr neuron Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons. PMID:18680739 KA interneuron PMID:15539490 KA neuron PMID:9634146 An auditory hair cell located in the macula that is sensitive to auditory stimuli. cell macular hair cell An auditory hair cell located in the macula that is sensitive to auditory stimuli. GO:cvs A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts. cell renal principal cell A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts. CL:CVS A cuboidal epithelial cell of the kidney that regulates acid/base balance. FMA:86560 intercalated cell cell renal intercalated cell A cuboidal epithelial cell of the kidney that regulates acid/base balance. CL:CVS A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance. cell renal alpha-intercalated cell A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance. CL:CVS A ciliated epithelial cell with many cilium. cell multi-ciliated epithelial cell A ciliated epithelial cell with many cilium. CL:CVS A ciliated epithelial cell with a single cilium. cell single ciliated epithelial cell A ciliated epithelial cell with a single cilium. CL:CVS A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells. cell auditory epithelial support cell A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells. CL:CVS GOC:tfm An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells. FMA:79801 cell inner phalangeal cell An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells. CL:CVS Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote. cell replaced_by: PO:0030007 obsolete apical cell true Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote. TAIR:TB Obsolete. Use PO:0002002 from Plant Ontology instead. The lower cell formed after the first division of a plant zygote. cell replaced_by: PO:0002002 obsolete plant basal cell true Obsolete. Use PO:0002002 from Plant Ontology instead. The lower cell formed after the first division of a plant zygote. TAIR:TB A cell that secretes ghrelin, the peptide hormone that stimulates hunger. cell ghrelin secreting cell A cell that secretes ghrelin, the peptide hormone that stimulates hunger. CL:curator Ghrelin secreting cells found in the found in the exocrine pancreas. pancreatic E cell cell In mammals the endocrine pancreas is called the Islets of Langerhans. pancreatic epsilon cell Ghrelin secreting cells found in the found in the exocrine pancreas. PMID:14970313 Lymphatic progenitor cells. Ceri 2012-01-12T04:44:34Z cell Usually express Prox1, or prox1b. lymphangioblast true Lymphatic progenitor cells. CL:CVS Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics. Ceri 2012-01-12T05:01:22Z cell mesenchymal lymphangioblast Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics. PMID:15624319 PMID:18430230 Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells. Ceri 2012-01-12T05:21:09Z parachordal lymphangioblast cell vascular lymphangioblast true Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells. CL:CVS Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches. PMID:14699587 branchi motor neuron special visceral motor neuron branchiomotor neuron Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches. ZFIN:CVS A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic. somatic motor neuron somatomotor neuron A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic. ZFIN:CVS A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems. general visceral motor neuron Note that these neurons do not synapse directly onto muscles visceromotor neuron A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems. ZFIN:CVS Multi fate stem cell that gives rise to to both hepatocytes and cholangiocytes as descendants. hepatoblast Multi fate stem cell that gives rise to to both hepatocytes and cholangiocytes as descendants. GOC:CVS PMID:18356246 PMID:20483998 Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins. haendel 2012-06-15T01:27:01Z cell unsure of neural crest contribution. In VSAO we have develops_from CL:0000008 preameloblast Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins. GO_REF:0000034 PMCID:PMC2737325 Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). haendel 2012-06-15T02:51:27Z scleroblast cell Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) skeletogenic cell Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). GO_REF:0000034 scleroblast GO_REF:0000034 Skeletogenic cell that has the potential to develop into a cementoblast. haendel 2012-06-15T04:37:13Z cell precementoblast Skeletogenic cell that has the potential to develop into a cementoblast. GO_REF:0000034 Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell. haendel 2012-06-15T05:15:11Z cell preodontoblast Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell. GO_REF:0000034 Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. haendel 2012-06-27T08:27:35Z cell premigratory neural crest cell Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. UBERONREF:0000002 Cell that is part of the notochord. haendel 2012-06-27T08:47:31Z cell NOTE: TO DO, notochord development still needs work. notochordal cell Cell that is part of the notochord. GO_REF:0000034 Mesodermal cell that is axially located and gives rise to the cells of the notochord. haendel 2012-06-27T08:52:41Z axial mesodermal cell cell chordamesodermal cell Mesodermal cell that is axially located and gives rise to the cells of the notochord. GO_REF:0000034 Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells. haendel 2012-06-27T09:26:37Z cell notochordal sheath cell Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells. CL:MAH Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds. haendel 2012-06-27T09:29:30Z chordablast chordoblast cell notochordal vacuole cell Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds. CL:MAH chordablast GO_REF:0000034 chordoblast PMID:14574572 Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. haendel 2012-06-27T10:44:01Z cell prechondroblast Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. GO_REF:0000034 Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells. haendel 2012-06-27T10:57:21Z osteoprogenitor cell cell preosteoblast Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells. GO_REF:0000034 Neuron that is part of the enteric nervous system. haendel 2012-06-28T08:20:31Z cell enteric neuron Neuron that is part of the enteric nervous system. CL:MAH Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell. cl non-terminally differentiated odontoblast Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell. GO_REF:0000034 PSPUB:0000170 Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine. cl terminally differentiated odontoblast Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine. GO_REF:0000034 OBSOLETE: A cultured cell that has been passaged at least one time in culture. haendel 2012-11-28T11:54:59Z passaged cultured cell cell Obsoleted in July 2013 and replaced by the CLO 'cell line cell' class, as a result of CLO-OBI-CL alignment efforts. Covers cells actively being cultured or stored in a quiescent state for future use. obsolete cell line cell true OBSOLETE: A cultured cell that has been passaged at least one time in culture. ReO:mhb OBSOLETE: A cell line cell that is expected to be capable of replicating a limited number of times in culture before undergoing senescence. Mortal cell line cells cannot be propagated indefinitely (as immortal cell line cells can). haendel 2012-11-28T11:56:20Z finite cell line cell cell primary cell line cell Obsoleted in July 2013 and replaced by the CLO 'mortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts. Covers cells actively being cultured or stored in a quiescent state for future use. obsolete mortal cell line cell true OBSOLETE: A cell line cell that is expected to be capable of replicating a limited number of times in culture before undergoing senescence. Mortal cell line cells cannot be propagated indefinitely (as immortal cell line cells can). ReO:mhb Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm. haendel 2012-12-30T12:43:15Z cell In teleosts, adaxial cells give rise to slow muscle myoblasts. adaxial cell Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm. PMID:8951054 An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis. haendel Taxon specificity not yet fully known, but are known in anuran larvae but not in adults. Stiftchenzellen An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis. PMID:1087183 Ciliated cell of the embryonic epidermis and functions in embryonic movements. haendel Taxon specificity not clear -present in embryonic anurans. epidermal ciliary cell Ciliated cell of the embryonic epidermis and functions in embryonic movements. PMCID:PMC3046089 haendel taxon specificity not clear. Appears in early larval stages of anurans and persists after metamorphosis. epidermal mucus secreting cell Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians. haendel bottle cell Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians. PMID:3197630 Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992] haendel club cell alarm substance cell Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992] ISBN-10:0412429403 club cell ISBN-10:0412429403 A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg. haendel plug cell micropylar cell A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg. PMID:18582455 ZFA:0005239 Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis. haendel flask cell Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis. DOI:10.1007/BF00717048 Any muscle cell in which the fibers are not organised into sarcomeres. non-striated muscle cell Any muscle cell in which the fibers are not organised into sarcomeres. GOC:DOS Any hematopoietic cell that is a precursor of some other hematopoietic cell type. hematopoietic precursor cell Any hematopoietic cell that is a precursor of some other hematopoietic cell type. GOC:dos A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. skeletal muscle fiber A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. GOC:tfm ISBN:0323052908 A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells. somatic muscle myotube A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells. PMID:22274696 PMID:8720463 A muscle cell that is part of some somatic muscle. somatic muscle cell A muscle cell that is part of some somatic muscle. GOC:dos A somatic muscle cell that is oblquely striated. Examples include the somatic muscles of nematodes. obliquely striated somatic muscle cell A somatic muscle cell that is oblquely striated. Examples include the somatic muscles of nematodes. PMID:8720463 A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) . It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621). cell muscle founder cell A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) . It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621). PMID:22274696 A muscle cell that is part of some visceral muscle visceral muscle cell A muscle cell that is part of some visceral muscle GOC:dos A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. striated visceral muscle cell A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. GOC:dos A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. transversely striated visceral muscle cell A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. GOC:dos A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue. cranial somatomotor neuron A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue. PMID:14699587 A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast. cell skeletal muscle satellite stem cell A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast. PMID:23303905 A skeletal muscle satellite cell that is mitotically quiescent. These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage. cell quiescent skeletal muscle satellite cell A skeletal muscle satellite cell that is mitotically quiescent. These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage. PMID:21849021 PMID:23303905 A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head. cranial visceromotor neuron A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head. PMID:14699587 A motor neuron that is capable of directly inducing muscle contraction. In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. excitatory motor neuron A motor neuron that is capable of directly inhibiting muscle contraction. In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. inhibitory motor neuron A skeletal muscle cell that has become mitotically active - typically following muscle damage. cell activated skeletal muscle satellite cell More accurately - transformation_of ? A skeletal muscle cell that has become mitotically active - typically following muscle damage. PMID:21849021 PMID:23303905 A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. myogenic precursor cell cell The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. adult skeletal muscle myoblast A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. PMID:23303905 myogenic precursor cell PMID:23303905 A myoblast that is commited to developing into a somatic muscle. cell somatic muscle myoblast A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration. mesenchyme cell mesenchymal cell A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts. cell skeletal muscle satellite myogenic cell A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts. GOC:dos PMID:23303905 anterior lateral line ganglion neuron A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. endocardial cushion cell A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. PMID:18816864 Duplicate term. cardiac fibroblast true An endocrine cell that is part of the pancreas. cell pancreatic endocrine cell An endocrine cell that is part of the pancreas. GOC:dos A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter. noradrenergic neuron A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter. GOC:dos An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects. cell open tracheal system tracheocyte An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects. GOC:dos A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. spinal sensory neuron sensory neuron of spinal nerve true A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. GOC:nv GOC:pr Any cell in the compound eye, a light sensing organ composed of ommatidia. GOC:pr PMID:12021768 compound eye retinal cell Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage. GOC:pr http://en.wikipedia.org/wiki/Inflammatory_response inflammatory cell Any cell in the midgut (middle subdivision of a digestive tract) of a larva. GOC:pr http://en.wikipedia.org/wiki/Insect#Midgut larval midgut cell Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. PMID:10702418 cell retinal cell Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. GOC:pr Any cell in a salivary gland. GOC:pr http://en.wikipedia.org/wiki/Salivary_gland salivary gland cell A hair follicle matrix region cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the hair bulb to become the hair medulla cortex and hair root sheath. keratinized cell of hair follicle A hair follicle matrix region cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the hair bulb to become the hair medulla cortex and hair root sheath. a stromal cell that is part_of a bone marrow GOC:cjm bone marrow stromal cell stromal cell of bone marrow a epithelial cell that is part_of a umbilical artery GOC:cjm umbilical artery epithelial cell epithelial cell of umbilical artery a epithelial cell that is part_of a alveolus of lung GOC:cjm alveolus of lung epithelial cell May be merged with pneumocyte in future epithelial cell of alveolus of lung a mononuclear cell that is part_of a bone marrow GOC:cjm bone marrow mononuclear cell mononuclear cell of bone marrow A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers. AV bundle cell atrioventricular bundle cell A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers. GOC:mtg_heart cardiac blood vessel endothelial cell His-Purkinje system cell cardiac endothelial cell camera type eye photoreceptor cell camera-type eye photoreceptor cell GOC:cjm cerebellar stellate cell a GABAergic interneuron that is part_of a cerebral cortex cerebral cortex GABAergic interneuron a neuron that is part_of a cerebral cortex cerebral cortex neuron light pinealocyte type I pinealocyte dark pinealocyte type II pinealocyte A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess. Editor note: remember to link to Saccus vasculosus in next uberon release coronet cell A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess. GOC:mr PMID:17595538 A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms. cell collar cell A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms. PMID:25840473 cardiac glial cell cell cardiac myoblast cardiac neuron A CNS interneuron located in the dorsal horn of the spinal cord. dorsal spinal cord interneuron dorsal horn interneuron true A CNS interneuron located in the dorsal horn of the spinal cord. GOC:nv A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. spinal cord motor neuron true A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. GOC:nv A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme. Need to MIREOT in 'spinal cord lateral column' from Uberon lateral motor column neuron A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme. GOC:nv A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that secretes the hormones oxytocin and vasopressin. magnocellular neuron magnocellular neurosecretory cell (duplicate class) A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that secretes the hormones oxytocin and vasopressin. GOC:nv MP:0009467 A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. lens fibre cell lens fiber cell A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. GO:0070307 GOC:nv An interneuron that uses GABA as a vesicular neurotransmitter. GABAergic interneuron An interneuron that uses GABA as a vesicular neurotransmitter. GOC:nv An inhibitory GABAergic interneuron found in the cerebellar cortex. Lugaro cell An inhibitory GABAergic interneuron found in the cerebellar cortex. GOC:nv A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. paraxial mesoderm cell somitic mesoderm cell presomitic mesoderm cell paraxial cell A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. GOC:NV PMID:11687492 A hemocyte derived from head mesoderm, which enters the hemolymph as acirculating cell. embryonic hemocyte A hemocyte derived from head mesoderm, which enters the hemolymph as acirculating cell. GOC:NV PMID:17967061 A plasmatocyte derived from head mesoderm. embryonic plasmatocyte A plasmatocyte derived from head mesoderm. GOC:NV PMID:17967061 A cell derived from the mesoderm that is found at the periphery of the embryo. lateral mesodermal cell A cell derived from the mesoderm that is found at the periphery of the embryo. GOC:NV PMID:9169844 A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate. intermediate mesodermal cell A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate. GOC:NV ISBN:978-0-87969-707-5 A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. cell neural crest cell A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. https://orcid.org/0000-0001-5208-3432 https://orcid.org/0000-0002-9900-7880 Neuron that secretes the neurotransmitter galanin. galanergic neuron Neuron that secretes the neurotransmitter galanin. GOC:NV PMID:23159249 ZFIN:CVS ZFIN:YB Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer. chorionic trophoblast cell Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer. GOC:NV Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic. parasympathetic neuron Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic. GOC:NV isbn:0080923437 Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides. sympathetic neuron Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides. GOC:NV isbn:0080923437 A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer. Need to MIREOT retinal inner nuclear layer (part of) interplexiform cell A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer. GOC:NV PMID:12771169 A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer, using dopamine. This type of cell is found in Danio rerio. dopamanergic interplexiform cell A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer, using dopamine. GOC:NV PMID:12771169 A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer using GABA. This type of cell is found in many mammals. GABAnergic interplexiform cell A type of interneuron in the retinal inner nuclear layer which carries information from the inner plexiform layer and the outer plexiform layer using GABA. GOC:NV PMID:12771169 Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer. Muller glia Müller cell Muller cell Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer. GOC:NV PMID:21911394 Epithelial cell that is part of the colon epithelium. colonic epithelial cell colon epithelial cell Epithelial cell that is part of the colon epithelium. GOC:NV A neuron that releases hypocretin as a neurotransmitter. orexin hypocretin-secreting neuron A neuron that releases hypocretin as a neurotransmitter. GOC:NV PMID:23848055 Neuron that secretes histamine. histaminergic neuron Neuron that secretes histamine. GOC:NV PMID:22677810 Neuroendocrine cells that are born in the nasal placode during embryonic development and migrate through the nose and forebrain to the hypothalamus, where they regulate reproduction. GnRH neuron GnRH-secreting neuron gonadotropin releasing neuron Neuroendocrine cells that are born in the nasal placode during embryonic development and migrate through the nose and forebrain to the hypothalamus, where they regulate reproduction. GOC:NV PMID:21828096 Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland. magnocellular neurosecretory cell Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland. GOC:NV PMID:10711808 Neuron found in the spriral ganglion. spiral ganglion neuron Neuron found in the spriral ganglion. GOC:NV A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface. segmented neutrophil of bone marrow A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface. PMID:11138622 PMID:15514007 A cell that, by division or terminal differentiation, can give rise to other cell types. Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. precursor cell A cell that, by division or terminal differentiation, can give rise to other cell types. GOC:dos An astrocyte of the forebrain. tberardini forebrain astrocyte cell astrocyte of the forebrain true A CNS neuron of the forebrain. tberardini forebrain neuron cell neuron of the forebrain true forebrain radial glial cell Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. PMID:14699587 cranial motoneuron cranial motor neuron Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. ZFIN:CVS retrotrapezoid nucleus neuron mesonephric nephron tubule epithelial cell forebrain neuroblast lateral line nerve glial cell spinal cord radial glial cell cell stretch receptor cell cell stratified keratinized epithelial stem cell cell stratified non keratinized epithelial stem cell pronephric nephron tubule epithelial cell metanephric nephron tubule epithelial cell lung goblet cell heart valve cell A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium. FBbt:00005797 Malpighian tubule Type II cell Malpighian tubule stellate cell A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium. GO:0061330 Malpighian tubule Type II cell FBbt:00005797 malpighian tubule tip cell A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti. FMA:75722 pillar cell of cochlea pillar cell of corti rod cell of Corti cell cochlear pillar cell pillar cell A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti. GOC:tfm PMID:12417662 growth plate cartilage chondrocyte stomach neuroendocrine cell lung neuroendocrine cell posterior lateral line nerve glial cell anterior lateral line nerve glial cell posterior lateral line ganglion neuron lung ciliated cell lung secretory cell trophectoderm cell cell trophectodermal cell A smooth muscle cell that is part of the small intestine. FMA:15050 non-striated muscle fiber of small intestine cell smooth muscle cell of small intestine true A smooth muscle cell that is part of the small intestine. GOC:tfm non-striated muscle fiber of small intestine FMA:15050 A smooth muscle cell that is part of the duodenum. FMA:15058 non-striated muscle fiber of duodenum cell smooth muscle fiber of duodenum true A smooth muscle cell that is part of the duodenum. GOC:tfm non-striated muscle fiber of duodenum FMA:15058 A smooth muscle cell that is part of the jejunum. FMA:15062 non-striated muscle fiber of jejunum cell smooth muscle fiber of jejunum true A smooth muscle cell that is part of the jejunum. GOC:tfm non-striated muscle fiber of jejunum FMA:15062 A smooth muscle cell that is part of the ileum. FMA:15066 non-striated muscle fiber of ileum cell smooth muscle fiber of ileum true A smooth muscle cell that is part of the ileum. GOC:tfm non-striated muscle fiber of ileum FMA:15066 A smooth muscle cell that is part of the large intestine. FMA:15653 non-striated muscle fiber of large intestine cell smooth muscle cell of large intestine true A smooth muscle cell that is part of the large intestine. GOC:tfm non-striated muscle fiber of large intestine FMA:15653 A smooth muscle cell that is part of the colon. FMA:15663 non-striated muscle fiber of colon cell smooth muscle cell of colon A smooth muscle cell that is part of the colon. GOC:tfm non-striated muscle fiber of colon FMA:15663 A smooth muscle cell that is part of the cecum. FMA:15681 non-striated muscle fiber of cecum smooth muscle fiber of cecum cell smooth muscle cell of cecum A smooth muscle cell that is part of the cecum. GOC:tfm non-striated muscle fiber of cecum FMA:15681 A smooth muscle cell that is part of the ascending colon. FMA:17518 non-striated muscle fiber of ascending colon cell smooth muscle fiber of ascending colon true A smooth muscle cell that is part of the ascending colon. GOC:tfm non-striated muscle fiber of ascending colon FMA:17518 A smooth muscle cell that is part of the transverse colon. FMA:17519 non-striated muscle fiber of transverse colon cell smooth muscle fiber of transverse colon true A smooth muscle cell that is part of the transverse colon. GOC:tfm non-striated muscle fiber of transverse colon FMA:17519 A smooth muscle cell that is part of the descending colon. FMA:17520 non-striated muscle fiber of descending colon cell smooth muscle fiber of descending colon true A smooth muscle cell that is part of the descending colon. GOC:tfm non-striated muscle fiber of descending colon FMA:17520 A smooth muscle cell that is part of the sigmoid colon. FMA:17521 non-striated muscle fiber of sigmoid colon cell smooth muscle cell of sigmoid colon true A smooth muscle cell that is part of the sigmoid colon. GOC:tfm non-striated muscle fiber of sigmoid colon FMA:17521 A smooth muscle cell that is part of the rectum. FMA:17522 non-striated muscle fiber of rectum smooth muscle fiber of rectum cell smooth muscle cell of rectum A smooth muscle cell that is part of the rectum. GOC:tfm non-striated muscle fiber of rectum FMA:17522 A muscle cell that is part of the anterior internodal tract. FMA:223276 cell myocyte of anterior internodal tract A muscle cell that is part of the anterior internodal tract. GOC:tfm A muscle cell that is part of the atrial branch of anterior internodal tract. FMA:223277 cell myocyte of atrial branch of anterior internodal tract A muscle cell that is part of the atrial branch of anterior internodal tract. GOC:tfm A muscle cell that is part of the atrial septal branch of anterior internodal tract. FMA:223278 cell myocyte of atrial septal branch of anterior internodal tract A muscle cell that is part of the atrial septal branch of anterior internodal tract. GOC:tfm A muscle cell that is part of the middle internodal tract. FMA:223279 cell myocyte of middle internodal tract A muscle cell that is part of the middle internodal tract. GOC:tfm A muscle cell that is part of the posterior internodal tract. FMA:223280 cell myocyte of posterior internodal tract A muscle cell that is part of the posterior internodal tract. GOC:tfm An epithelial cell that is part of the urethra. FMA:256165 cell epithelial cell of urethra true An epithelial cell that is part of the urethra. GOC:tfm A mesothelial cell that is part of the dura mater. FMA:256516 squamous mesothelial cell of dura mater cell mesothelial cell of dura mater true A mesothelial cell that is part of the dura mater. GOC:tfm squamous mesothelial cell of dura mater FMA:256516 A fibroblast that is part of the connective tissue of prostate. FMA:261271 cell fibroblast of connective tissue of prostate A fibroblast that is part of the connective tissue of prostate. GOC:tfm A fibroblast that is part of the outer membrane of prostatic capsule. FMA:261273 cell fibroblast of outer membrane of prostatic capsule A fibroblast that is part of the outer membrane of prostatic capsule. GOC:tfm A fibroblast that is part of the subepithelial connective tissue of prostatic gland. FMA:261275 cell fibroblast of subepithelial connective tissue of prostatic gland A fibroblast that is part of the subepithelial connective tissue of prostatic gland. GOC:tfm A fibroblast that is part of the papillary layer of dermis. FMA:261277 cell fibroblast of papillary layer of dermis true A fibroblast that is part of the papillary layer of dermis. GOC:tfm A fibroblast that is part of the areolar connective tissue. FMA:261279 cell fibroblast of areolar connective tissue true A fibroblast that is part of the areolar connective tissue. GOC:tfm A fibroblast that is part of the connective tissue of nonglandular part of prostate. FMA:261281 cell fibroblast of connective tissue of nonglandular part of prostate A fibroblast that is part of the connective tissue of nonglandular part of prostate. GOC:tfm A fibroblast that is part of the connective tissue of glandular part of prostate. FMA:261283 cell fibroblast of connective tissue of glandular part of prostate A fibroblast that is part of the connective tissue of glandular part of prostate. GOC:tfm A fibroblast that is part of the tunica adventitia of artery. FMA:261285 cell fibroblast of tunica adventitia of artery true A fibroblast that is part of the tunica adventitia of artery. GOC:tfm A fibroblast that is part of the dense regular elastic tissue. FMA:261287 cell fibroblast of dense regular elastic tissue A fibroblast that is part of the dense regular elastic tissue. GOC:tfm A fibrocyte that is part of the adventitia of ureter. FMA:261289 cell fibrocyte of adventitia of ureter true A fibrocyte that is part of the adventitia of ureter. GOC:tfm A fat cell that is part of the epicardial fat. FMA:261293 adipocyte of epicardial fat epicardial fat cell cell epicardial adipocyte A fat cell that is part of the epicardial fat. GOC:tfm adipocyte of epicardial fat FMA:261293 epicardial fat cell FMA:261293 A fat cell that is part of the epicardial fat of right ventricle. FMA:261297 epicardial adipocyte of right ventricle epicardial fat cell of right ventricle cell adipocyte of epicardial fat of right ventricle A fat cell that is part of the epicardial fat of right ventricle. GOC:tfm epicardial adipocyte of right ventricle FMA:261297 epicardial fat cell of right ventricle FMA:261297 A fat cell that is part of the epicardial fat of left ventricle. FMA:261300 epicardial adipocyte of left ventricle epicardial fat cell of left ventricle cell adipocyte of epicardial fat of left ventricle A fat cell that is part of the epicardial fat of left ventricle. GOC:tfm epicardial adipocyte of left ventricle FMA:261300 epicardial fat cell of left ventricle FMA:261300 A goblet cell that is part of the epithelium of bronchus. FMA:263032 goblet cell of epithelium of bronchus cell bronchial goblet cell A goblet cell that is part of the epithelium of bronchus. GOC:tfm goblet cell of epithelium of bronchus FMA:263032 A goblet cell that is part of the epithelium of stomach. FMA:263035 goblet cell of epithelium of stomach cell gastric goblet cell A goblet cell that is part of the epithelium of stomach. GOC:tfm goblet cell of epithelium of stomach FMA:263035 A goblet cell that is part of the epithelium of gastric cardiac gland. FMA:263038 goblet cell of epithelium of gastric cardiac gland cell gastric cardiac gland goblet cell A goblet cell that is part of the epithelium of gastric cardiac gland. GOC:tfm A goblet cell that is part of the epithelium of principal gastric gland. FMA:263040 goblet cell of epithelium of principal gastric gland cell principal gastric gland goblet cell A goblet cell that is part of the epithelium of principal gastric gland. GOC:tfm OBSOLETE: A goblet cell that is part of the epithelium of small intestine. CL:1000495 FMA:263042 cell obsolete goblet cell of epithelium of small intestine true OBSOLETE: A goblet cell that is part of the epithelium of small intestine. GOC:tfm A goblet cell that is part of the epithelium of intestinal villus. FMA:263046 goblet cell of epithelium of intestinal villus cell intestinal villus goblet cell A goblet cell that is part of the epithelium of intestinal villus. GOC:tfm A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine. FMA:263050 cell obsolete small intestine crypt goblet cell true A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine. GOC:tfm OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine. FMA:263052 cell obsolete goblet cell of epithelium proper of small intestine true OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine. GOC:tfm A goblet cell that is part of the epithelium of large intestine. FMA:263054 goblet cell of epithelium of large intestine cell large intestine goblet cell A goblet cell that is part of the epithelium of large intestine. GOC:tfm A goblet cell that is part of the epithelium of crypt of lieberkuhn of large intestine. FMA:263056 cell large intestine crypt goblet cell A goblet cell that is part of the epithelium of crypt of lieberkuhn of large intestine. GOC:tfm A goblet cell that is part of the epithelium of pancreatic duct. FMA:263058 goblet cell of epithelium of pancreatic duct cell pancreatic goblet cell A goblet cell that is part of the epithelium of pancreatic duct. GOC:tfm goblet cell of epithelium of pancreatic duct FMA:263058 A goblet cell that is part of the epithelium of pyloric gland. FMA:263061 goblet cell of epithelium of pyloric gland cell pylroric gastric gland goblet cell A goblet cell that is part of the epithelium of pyloric gland. GOC:tfm A goblet cell that is part of the epithelium proper of duodenum. FMA:263063 goblet cell of epithelium proper of duodenum cell duodenal goblet cell A goblet cell that is part of the epithelium proper of duodenum. GOC:tfm A goblet cell that is part of the epithelium proper of jejunum. FMA:263065 goblet cell of epithelium proper of jejunum cell jejunal goblet cell A goblet cell that is part of the epithelium proper of jejunum. GOC:tfm A goblet cell that is part of the epithelium proper of ileum. FMA:263067 goblet cell of epithelium proper of ileum cell ileal goblet cell A goblet cell that is part of the epithelium proper of ileum. GOC:tfm A goblet cell that is part of the epithelium proper of appendix. FMA:263069 goblet cell of epithelium proper of appendix cell appendix goblet cell A goblet cell that is part of the epithelium proper of appendix. GOC:tfm OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine. FMA:263071 cell obsolete goblet cell of epithelium proper of large intestine true OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine. GOC:tfm A goblet cell that is part of the epithelium of trachea. FMA:263075 goblet cell of epithelium of trachea cell tracheal goblet cell A goblet cell that is part of the epithelium of trachea. GOC:tfm goblet cell of epithelium of trachea FMA:263075 A serous secreting cell that is part of the epithelium of trachea. FMA:263078 cell serous cell of epithelium of trachea true A serous secreting cell that is part of the epithelium of trachea. GOC:tfm A serous secreting cell that is part of the epithelium of bronchus. FMA:263080 cell serous cell of epithelium of bronchus A serous secreting cell that is part of the epithelium of bronchus. GOC:tfm A serous secreting cell that is part of the epithelium of terminal bronchiole. FMA:263082 cell serous cell of epithelium of terminal bronchiole A serous secreting cell that is part of the epithelium of terminal bronchiole. GOC:tfm A serous secreting cell that is part of the epithelium of bronchiole. FMA:263084 cell serous cell of epithelium of lobular bronchiole A serous secreting cell that is part of the epithelium of bronchiole. GOC:tfm An enterocyte that is part of the epithelium of small intestine. FMA:263086 cell enterocyte of epithelium of small intestine true An enterocyte that is part of the epithelium of small intestine. GOC:tfm An enterocyte that is part of the epithelium of intestinal villus. FMA:263088 cell enterocyte of epithelium of intestinal villus An enterocyte that is part of the epithelium of intestinal villus. GOC:tfm An enterocyte that is part of the epithelium of duodenal gland. FMA:263092 cell enterocyte of epithelium of duodenal gland An enterocyte that is part of the epithelium of duodenal gland. GOC:tfm An enterocyte that is part of the epithelium of crypt of lieberkuhn of small intestine. FMA:263094 cell enterocyte of epithelium of crypt of Lieberkuhn of small intestine An enterocyte that is part of the epithelium of crypt of lieberkuhn of small intestine. GOC:tfm An enterocyte that is part of the epithelium proper of small intestine. FMA:263096 cell enterocyte of epithelium proper of small intestine An enterocyte that is part of the epithelium proper of small intestine. GOC:tfm An enterocyte that is part of the epithelium proper of duodenum. FMA:263098 cell enterocyte of epithelium proper of duodenum An enterocyte that is part of the epithelium proper of duodenum. GOC:tfm An enterocyte that is part of the epithelium proper of jejunum. FMA:263100 cell enterocyte of epithelium proper of jejunum An enterocyte that is part of the epithelium proper of jejunum. GOC:tfm An enterocyte that is part of the epithelium proper of ileum. FMA:263102 cell enterocyte of epithelium proper of ileum An enterocyte that is part of the epithelium proper of ileum. GOC:tfm A paneth cell that is part of the epithelium of small intestine. FMA:263104 cell paneth cell of epithelium of small intestine true A paneth cell that is part of the epithelium of small intestine. GOC:tfm A Paneth cell that is part of the epithelium proper of small intestine. FMA:263106 cell paneth cell of epithelium proper of small intestine A Paneth cell that is part of the epithelium proper of small intestine. GOC:tfm A Paneth cell that is part of the epithelium of crypt of lieberkuhn of small intestine. FMA:263108 cell paneth cell of epithelium of crypt of Lieberkuhn of small intestine A Paneth cell that is part of the epithelium of crypt of lieberkuhn of small intestine. GOC:tfm MERGED DEFINITION: TARGET DEFINITION: A columnar cell of the colon that is part of the epithelium proper of large intestine. SOURCE DEFINITION: An enterocyte that is part of the epithelium proper of large intestine. CL:1000336 FMA:263090 FMA:263112 enterocyte of epithelium proper of large intestine cell vacuolar absorptive cell of epithelium proper of large intestine MERGED DEFINITION: TARGET DEFINITION: A columnar cell of the colon that is part of the epithelium proper of large intestine. SOURCE DEFINITION: An enterocyte that is part of the epithelium proper of large intestine. GOC:tfm A columnar cell of the colon that is part of the colonic epithelium. FMA:263114 cell vacuolar absorptive cell of epithelium of colon true A columnar cell of the colon that is part of the colonic epithelium. GOC:tfm A basal cell that is part of the epithelium of trachea. FMA:263118 cell basal cell of epithelium of trachea true A basal cell that is part of the epithelium of trachea. GOC:tfm A basal cell found in the bronchus epithelium. CL:0002331 FMA:263120 basal cell of bronchus cell basal cell of epithelium of bronchus A basal cell found in the bronchus epithelium. GOC:tfm A basal cell that is part of the epithelium of terminal bronchiole. FMA:263122 cell basal cell of epithelium of terminal bronchiole A basal cell that is part of the epithelium of terminal bronchiole. GOC:tfm A basal cell that is part of the epithelium of respiratory bronchiole. FMA:263124 cell basal cell of epithelium of respiratory bronchiole A basal cell that is part of the epithelium of respiratory bronchiole. GOC:tfm A basal cell that is part of the epithelium of bronchiole. FMA:263126 cell basal cell of epithelium of lobular bronchiole A basal cell that is part of the epithelium of bronchiole. GOC:tfm A M cell that is part of the epithelium of small intestine. FMA:263128 cell microfold cell of epithelium of small intestine true A M cell that is part of the epithelium of small intestine. GOC:tfm A M cell that is part of the epithelium of intestinal villus. FMA:263130 cell microfold cell of epithelium of intestinal villus A M cell that is part of the epithelium of intestinal villus. GOC:tfm A M cell that is part of the epithelium proper of small intestine. FMA:263132 cell microfold cell of epithelium proper of small intestine A M cell that is part of the epithelium proper of small intestine. GOC:tfm A M cell that is part of the epithelium proper of duodenum. FMA:263134 cell microfold cell of epithelium proper of duodenum A M cell that is part of the epithelium proper of duodenum. GOC:tfm A M cell that is part of the epithelium proper of jejunum. FMA:263136 cell microfold cell of epithelium proper of jejunum A M cell that is part of the epithelium proper of jejunum. GOC:tfm A M cell that is part of the epithelium proper of ileum. FMA:263138 cell microfold cell of epithelium proper of ileum A M cell that is part of the epithelium proper of ileum. GOC:tfm A M cell that is part of the epithelium proper of appendix. FMA:263140 cell microfold cell of epithelium proper of appendix A M cell that is part of the epithelium proper of appendix. GOC:tfm A M cell that is part of the epithelium proper of large intestine. FMA:263142 cell microfold cell of epithelium proper of large intestine A M cell that is part of the epithelium proper of large intestine. GOC:tfm A transitional myocyte that is part of the interatrial septum. FMA:263152 cell transitional myocyte of interatrial septum true A transitional myocyte that is part of the interatrial septum. GOC:tfm A transitional myocyte that is part of the interventricular septum. FMA:263154 cell transitional myocyte of interventricular septum true A transitional myocyte that is part of the interventricular septum. GOC:tfm A transitional myocyte that is part of the atrial branch of anterior internodal tract. FMA:263156 cell transitional myocyte of atrial branch of anterior internodal tract A transitional myocyte that is part of the atrial branch of anterior internodal tract. GOC:tfm A transitional myocyte that is part of the anterior internodal tract. FMA:263158 cell transitional myocyte of anterior internodal tract A transitional myocyte that is part of the anterior internodal tract. GOC:tfm A transitional myocyte that is part of the atrial septal branch of anterior internodal tract. FMA:263160 cell transitional myocyte of atrial septal branch of anterior internodal tract A transitional myocyte that is part of the atrial septal branch of anterior internodal tract. GOC:tfm A transitional myocyte that is part of the middle internodal tract. FMA:263162 cell transitional myocyte of middle internodal tract A transitional myocyte that is part of the middle internodal tract. GOC:tfm A transitional myocyte that is part of the posterior internodal tract. FMA:263164 cell transitional myocyte of posterior internodal tract A transitional myocyte that is part of the posterior internodal tract. GOC:tfm A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle. FMA:263166 cell transitional myocyte of anterior division of left branch of atrioventricular bundle A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle. GOC:tfm A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle. FMA:263168 cell transitional myocyte of septal division of left branch of atrioventricular bundle A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle. GOC:tfm A transitional myocyte that is part of the left branch of atrioventricular bundle. FMA:263170 cell transitional myocyte of left branch of atrioventricular bundle A transitional myocyte that is part of the left branch of atrioventricular bundle. GOC:tfm A transitional myocyte that is part of the right branch of atrioventricular bundle. FMA:263172 cell transitional myocyte of right branch of atrioventricular bundle A transitional myocyte that is part of the right branch of atrioventricular bundle. GOC:tfm A transitional myocyte that is part of the atrial part of atrioventricular bundle. FMA:263174 cell transitional myocyte of atrial part of atrioventricular bundle A transitional myocyte that is part of the atrial part of atrioventricular bundle. GOC:tfm A transitional myocyte that is part of the ventricular part of atrioventricular bundle. FMA:263176 cell transitional myocyte of ventricular part of atrioventricular bundle A transitional myocyte that is part of the ventricular part of atrioventricular bundle. GOC:tfm A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle. FMA:263178 cell transitional myocyte of posterior division of left branch of atrioventricular bundle A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle. GOC:tfm A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle. FMA:263180 cell myocardial endocrine cell of septal division of left branch of atrioventricular bundle A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle. GOC:tfm A Purkinje myocyte that is part of the interventricular septum. FMA:263182 cell Purkinje myocyte of interventricular septum true A Purkinje myocyte that is part of the interventricular septum. GOC:tfm A Feyrter cell that is part of the epithelium of trachea. FMA:263184 cell dense-core granulated cell of epithelium of trachea true true A Feyrter cell that is part of the epithelium of trachea. GOC:tfm A type I vestibular sensory cell that is part of the stato-acoustic epithelium. FMA:263186 cell type 1 vestibular sensory cell of stato-acoustic epithelium A type I vestibular sensory cell that is part of the stato-acoustic epithelium. GOC:tfm A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth. FMA:263188 cell type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth. GOC:tfm A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth. FMA:263190 cell type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth. GOC:tfm A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth. FMA:263192 cell type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth. GOC:tfm A type II vestibular sensory cell that is part of the stato-acoustic epithelium. FMA:263194 cell type 2 vestibular sensory cell of stato-acoustic epithelium A type II vestibular sensory cell that is part of the stato-acoustic epithelium. GOC:tfm A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth. FMA:263196 cell type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth. GOC:tfm A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth. FMA:263198 cell type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth. GOC:tfm A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth. FMA:263200 cell type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth. GOC:tfm A melanocyte that is part of the eyelid. FMA:59175 eyelid melanocyte sebaceous gland of wolff cell melanocyte of eyelid true A melanocyte that is part of the eyelid. GOC:tfm eyelid melanocyte FMA:59175 sebaceous gland of wolff FMA:59175 A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct. FMA:62158 cell myoepithelial cell of intralobular lactiferous duct A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct. GOC:tfm An endothelial cell that is part of the venous sinus of red pulp of spleen. FMA:62817 cell todo - add logical definition to UBERON:0009967 endothelial cell of venous sinus of red pulp of spleen An endothelial cell that is part of the venous sinus of red pulp of spleen. GOC:tfm An endothelial cell that is part of the hepatic sinusoid. FMA:62911 endotheliocyte of hepatic sinusoid cell endothelial cell of hepatic sinusoid true An endothelial cell that is part of the hepatic sinusoid. GOC:tfm endotheliocyte of hepatic sinusoid FMA:62911 An epithelial cell that is part of the appendix. FMA:63602 columnar epitheliocyte of appendix epithelial cell of vermiform appendix cell epithelial cell of appendix An epithelial cell that is part of the appendix. GOC:tfm columnar epitheliocyte of appendix FMA:63602 epithelial cell of vermiform appendix FMA:63602 A muscle cell that is part of the sinoatrial node. FMA:67102 SA nodal myocyte SA node cardiac muscle cell myocyte of sinoatrial node sinoatrial node cell sinoatrial node myocyte sinuatrial node myocyte cell myocyte of sinoatrial node A muscle cell that is part of the sinoatrial node. FMA:67102 GOC:tfm SA nodal myocyte FMA:67102 SA node cardiac muscle cell GOC:pr myocyte of sinoatrial node FMA:67102 sinoatrial node cell GOC:pr sinuatrial node myocyte FMA:67102 A muscle cell that is part of the atrioventricular node. FMA:67106 AV nodal myocyte AV node cardiac muscle cell AV node cell atrioventricular node cell atrioventricular node myocyte cell myocyte of atrioventricular node A muscle cell that is part of the atrioventricular node. FMA:67106 GOC:tfm AV nodal myocyte FMA:67106 AV node cardiac muscle cell GOC:pr AV node cell GOC:pr atrioventricular node cell GOC:pr atrioventricular node myocyte FMA:67106 An endothelial cell that is part of the small intestine Peyer's patch. FMA:67757 cell endothelial cell of Peyer's patch true An endothelial cell that is part of the small intestine Peyer's patch. GOC:tfm An endothelial cell that is part of the arteriole. FMA:67760 KUPO:0001097 cell endothelial cell of arteriole true An endothelial cell that is part of the arteriole. GOC:tfm A blood vessel endothelial cell that is part of an arterial endothelium. CL:0002542 BTO:0004758 FMA:67761 KUPO:0001095 arterial endothelial cell cell endothelial cell of artery A blood vessel endothelial cell that is part of an arterial endothelium. GOC:tfm An endothelial cell that is part of the venule. FMA:67762 cell endothelial cell of venule true An endothelial cell that is part of the venule. GOC:tfm An epithelial cell that is part of the gallbladder. FMA:67780 cell epithelial cell of gall bladder true An epithelial cell that is part of the gallbladder. GOC:tfm A myoepithelial cell that is part of the mammary gland. CALOHA:TS-2378 FMA:67800 basal cell of lactiferous duct cell myoepithelial cell of lactiferous gland true A myoepithelial cell that is part of the mammary gland. GOC:tfm basal cell of lactiferous duct FMA:67800 A myoepithelial cell that is part of the sweat gland. FMA:67801 cell myoepithelial cell of sweat gland true A myoepithelial cell that is part of the sweat gland. GOC:tfm A myoepithelial cell that is part of the mammary gland alveolus. FMA:67802 basal cell of alveolus of lactiferous gland myoepithelial cell of mammary alveolus cell myoepithelial cell of lactiferous alveolus A myoepithelial cell that is part of the mammary gland alveolus. GOC:tfm basal cell of alveolus of lactiferous gland FMA:67802 myoepithelial cell of mammary alveolus FMA:67802 A myoepithelial cell that is part of the lactiferous duct. FMA:67803 cell myoepithelial cell of lactiferous duct A myoepithelial cell that is part of the lactiferous duct. GOC:tfm A myoepithelial cell that is part of the terminal lactiferous duct. FMA:67804 cell myoepithelial cell of terminal lactiferous duct A myoepithelial cell that is part of the terminal lactiferous duct. GOC:tfm A chromaffin cell that is part of the paraaortic body. FMA:69328 chromaffin cell of para-aortic body cell chromaffin cell of paraaortic body A chromaffin cell that is part of the paraaortic body. GOC:tfm chromaffin cell of para-aortic body FMA:69328 A chromaffin cell that is part of the paraganglion. FMA:69335 cell chromaffin cell of paraganglion true A chromaffin cell that is part of the paraganglion. GOC:tfm A chromaffin cell that is part of the adrenal gland. FMA:69794 adrenal chromaffin cell cell chromaffin cell of adrenal gland true A chromaffin cell that is part of the adrenal gland. GOC:tfm adrenal chromaffin cell GO:0061104 A chromaffin cell that is part of the adrenal cortex. FMA:69795 chromaffin cell of adrenal cortex cell Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin. adrenal cortex chromaffin cell A chromaffin cell that is part of the adrenal cortex. GOC:tfm A somatic stem cell that is part of the epidermis. FMA:70541 epidermal stem cell cell stem cell of epidermis true A somatic stem cell that is part of the epidermis. GOC:tfm epidermal stem cell FMA:70541 An epithelial cell that is part of the conjunctiva. FMA:70552 epithelial cell of conjunctiva cell conjunctival epithelial cell true An epithelial cell that is part of the conjunctiva. GOC:tfm epithelial cell of conjunctiva FMA:70552 An epithelial cell that is part of the lacrimal canaliculus. FMA:70553 cell epithelial cell of lacrimal canaliculus true An epithelial cell that is part of the lacrimal canaliculus. GOC:tfm An epithelial cell that is part of the external acoustic meatus. FMA:70555 cell epithelial cell of external acoustic meatus true An epithelial cell that is part of the external acoustic meatus. GOC:tfm An epithelial cell that is part of the lacrimal duct. FMA:70559 cell epithelial cell of lacrimal duct true An epithelial cell that is part of the lacrimal duct. GOC:tfm An epithelial cell that is part of the lacrimal sac. FMA:70560 cell epithelial cell of lacrimal sac An epithelial cell that is part of the lacrimal sac. GOC:tfm An epithelial cell that is part of the nasolacrimal duct. FMA:70561 cell epithelial cell of nasolacrimal duct An epithelial cell that is part of the nasolacrimal duct. GOC:tfm An epithelial cell that is part of the wall of inferior part of anal canal. FMA:70562 cell epithelial cell of wall of inferior part of anal canal An epithelial cell that is part of the wall of inferior part of anal canal. GOC:tfm An epithelial cell that is part of the viscerocranial mucosa. FMA:70583 cell epithelial cell of viscerocranial mucosa An epithelial cell that is part of the viscerocranial mucosa. GOC:tfm An urothelial cell that is part of the trigone of urinary bladder. FMA:70598 epithelial cell of vesical trigone cell urothelial cell of trigone of urinary bladder true An urothelial cell that is part of the trigone of urinary bladder. GOC:tfm epithelial cell of vesical trigone FMA:70598 A smooth muscle cell that is part of the ciliary body. FMA:70610 smooth muscle cell of ciliary body cell ciliary muscle cell true A smooth muscle cell that is part of the ciliary body. GOC:tfm smooth muscle cell of ciliary body FMA:70610 A mesothelial cell that is part of the anterior chamber of eyeball. FMA:70615 cell mesothelial cell of anterior chamber of eye true A mesothelial cell that is part of the anterior chamber of eyeball. GOC:tfm A myoepithelial cell that is part of the dilatator pupillae. FMA:70619 cell myoepithelial cell of dilator pupillae true A myoepithelial cell that is part of the dilatator pupillae. GOC:tfm A basal cell that is part of the epithelium of esophagus. FMA:70731 basal cell of esophageal epithelium cell epithelial cell of stratum germinativum of esophagus true A basal cell that is part of the epithelium of esophagus. GOC:tfm basal cell of esophageal epithelium FMA:70731 An epithelial cell that is part of the sweat gland. FMA:70952 cell epithelial cell of sweat gland An epithelial cell that is part of the sweat gland. GOC:tfm An epithelial cell that is part of the nephron. FMA:70965 cell epithelial cell of nephron An epithelial cell that is part of the nephron. GOC:tfm An epithelial cell that is part of the glomerular capsule. FMA:70966 KUPO:0001034 Bowmans capsule epithelial cell epithelial cell of Bowman's capsule cell epithelial cell of glomerular capsule An epithelial cell that is part of the glomerular capsule. GOC:tfm epithelial cell of Bowman's capsule FMA:70966 An epithelial cell that is part of the visceral layer of glomerular capsule. FMA:70967 glomerular podocyte cell consider merging into CL:0000653 epithelial cell of visceral layer of glomerular capsule An epithelial cell that is part of the visceral layer of glomerular capsule. GOC:tfm glomerular podocyte FMA:70967 An epithelial cell that is part of the glomerular parietal epithelium. CL:1000897 FMA:70968 KUPO:0001035 epithelial cell of parietal layer of glomerular capsule cell parietal epithelial cell An epithelial cell that is part of the glomerular parietal epithelium. GOC:tfm epithelial cell of parietal layer of glomerular capsule FMA:70968 An epithelial cell that is part of the intermediate tubule. FMA:70980 cell epithelial cell of intermediate tubule An epithelial cell that is part of the intermediate tubule. GOC:tfm An epithelial cell that is part of the collecting duct of renal tubule. FMA:70982 KUPO:0001059 epithelial cell of renal collecting tubule cell kidney collecting duct epithelial cell true true An epithelial cell that is part of the collecting duct of renal tubule. GOC:tfm epithelial cell of renal collecting tubule FMA:70982 A mesothelial cell that is part of the parietal peritoneum. FMA:72142 cell mesothelial cell of parietal peritoneum A mesothelial cell that is part of the parietal peritoneum. GOC:tfm A mesothelial cell that is part of the visceral peritoneum. FMA:72143 cell mesothelial cell of visceral peritoneum A mesothelial cell that is part of the visceral peritoneum. GOC:tfm A melanocyte that is part of the skin of body. CALOHA:TS-2374 FMA:72144 skin melanocyte cell melanocyte of skin true A melanocyte that is part of the skin of body. GOC:tfm skin melanocyte FMA:72144 A chromaffin cell that is part of the ovary. FMA:74319 cell chromaffin cell of ovary true A chromaffin cell that is part of the ovary. GOC:tfm A chromaffin cell that is part of the right ovary. FMA:74320 cell chromaffin cell of right ovary A chromaffin cell that is part of the right ovary. GOC:tfm A chromaffin cell that is part of the left ovary. FMA:74321 cell chromaffin cell of left ovary A chromaffin cell that is part of the left ovary. GOC:tfm A myoepithelial cell that is part of the acinus of lactiferous gland. FMA:74469 basal cell of acinus of lactiferous gland cell myoepithelial cell of acinus of lactiferous gland A myoepithelial cell that is part of the acinus of lactiferous gland. GOC:tfm basal cell of acinus of lactiferous gland FMA:74469 A myoepithelial cell that is part of the main lactiferous duct. FMA:74499 cell myoepithelial cell of main lactiferous duct A myoepithelial cell that is part of the main lactiferous duct. GOC:tfm A myoepithelial cell that is part of the primary lactiferous duct. FMA:74500 cell myoepithelial cell of primary lactiferous duct A myoepithelial cell that is part of the primary lactiferous duct. GOC:tfm A myoepithelial cell that is part of the secondary lactiferous duct. FMA:74501 cell myoepithelial cell of secondary lactiferous duct A myoepithelial cell that is part of the secondary lactiferous duct. GOC:tfm A myoepithelial cell that is part of the tertiary lactiferous duct. FMA:74502 cell myoepithelial cell of tertiary lactiferous duct A myoepithelial cell that is part of the tertiary lactiferous duct. GOC:tfm A myoepithelial cell that is part of the quarternary lactiferous duct. FMA:74503 cell myoepithelial cell of quarternary lactiferous duct A myoepithelial cell that is part of the quarternary lactiferous duct. GOC:tfm A nodal myocyte that is part of the sinoatrial node. FMA:83383 cardiac pacemaker cell of sinuatrial node pacemaker cell of sinoatrial node pacemaker cell of sinuatrial node cell cardiac pacemaker cell of sinoatrial node A nodal myocyte that is part of the sinoatrial node. GOC:tfm A transitional myocyte that is part of the sinoatrial node. FMA:83384 transitinal myocyte of sinuatrial node cell transitional myocyte of sinoatrial node true A transitional myocyte that is part of the sinoatrial node. GOC:tfm A Purkinje myocyte that is part of the atrioventricular node. FMA:83386 cell Purkinje myocyte of atrioventricular node true A Purkinje myocyte that is part of the atrioventricular node. GOC:tfm A transitional myocyte that is part of the internodal tract. FMA:83387 cell transitional myocyte of internodal tract true A transitional myocyte that is part of the internodal tract. GOC:tfm A transitional myocyte that is part of the atrioventricular bundle. FMA:83388 FMA:83885 cell transitional myocyte of atrioventricular bundle true A transitional myocyte that is part of the atrioventricular bundle. GOC:tfm A myocardial endocrine cell that is part of the interventricular septum. FMA:83390 cell myocardial endocrine cell of interventricular septum true A myocardial endocrine cell that is part of the interventricular septum. GOC:tfm A Purkinje myocyte that is part of the internodal tract. FMA:83392 cell Purkinje myocyte of internodal tract true A Purkinje myocyte that is part of the internodal tract. GOC:tfm A Purkinje myocyte that is part of the atrioventricular bundle. FMA:83393 cell Purkinje myocyte of atrioventricular bundle true A Purkinje myocyte that is part of the atrioventricular bundle. GOC:tfm A basal cell that is part of the urothelium. FMA:84150 cell basal cell of urothelium true A basal cell that is part of the urothelium. GOC:tfm A smooth muscle cell that is part of the prostate gland. FMA:84583 smooth muscle fiber of prostate cell smooth muscle cell of prostate true A smooth muscle cell that is part of the prostate gland. GOC:tfm smooth muscle fiber of prostate FMA:84583 An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. FMA:86481 epithelial cell of bile duct cell cholangiocyte true An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. GOC:tfm PMID:16550043 PMID:18356246 A reticular cell that is part of the splenic cord. FMA:86497 cell reticular cell of splenic cord true A reticular cell that is part of the splenic cord. GOC:tfm A mesothelial cell that is part of the peritoneum. FMA:86736 peritoneal mesothelial cell cell mesothelial cell of peritoneum true A mesothelial cell that is part of the peritoneum. GOC:tfm peritoneal mesothelial cell FMA:86736 A mesothelial cell that is part of the pleura. FMA:86737 pleural mesothelial cell cell mesothelial cell of pleura true A mesothelial cell that is part of the pleura. GOC:tfm pleural mesothelial cell FMA:86737 A mesothelial cell that is part of the parietal pleura. FMA:86738 cell mesothelial cell of parietal pleura A mesothelial cell that is part of the parietal pleura. GOC:tfm A mesothelial cell that is part of the visceral pleura. FMA:86739 cell mesothelial cell of visceral pleura A mesothelial cell that is part of the visceral pleura. GOC:tfm An epithelial cell that is part of a nephron tubule. FMA:86785 KUPO:0001022 kidney tubule epithelial cell cell This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON. nephron tubule epithelial cell An epithelial cell that is part of a nephron tubule. GOC:tfm A goblet cell that is part of the small intestine. FMA:86929 goblet cell of epithelium of small intestine goblet cell of small intestine small intestinal goblet cell cell small intestine goblet cell A goblet cell that is part of the small intestine. GOC:tfm small intestinal goblet cell FMA:86929 KUPO:0001010 cell kidney cell true KUPO:0001013 cell kidney interstitial cell true KUPO:0001017 cell kidney medulla cell true KUPO:0001018 cell kidney pelvis cell true KUPO:0001020 cell kidney tubule cell KUPO:0001023 cell kidney glomerular epithelial cell KUPO:0001060 cell kidney medulla collecting duct epithelial cell KUPO:0001061 cell kidney inner medulla collecting duct epithelial cell KUPO:0001062 cell kidney outer medulla collecting duct epithelial cell KUPO:0001063 cell kidney cortex collecting duct epithelial cell KUPO:0001064 cell kidney papillary duct principal epithelial cell KUPO:0001111 cell inner renal cortex cell KUPO:0001112 cell papillary tips cell KUPO:0001115 cell lower urinary tract cell true KUPO:0001116 cell ureteral cell true KUPO:0001015 cell kidney nerve cell KUPO:0001021 cell kidney corpuscule cell true KUPO:0001024 cell kidney cortex tubule cell true KUPO:0001025 cell kidney outer medulla cell true KUPO:0001026 cell kidney inner medulla cell true KUPO:0001028 juxtaglomerulus cell cell juxtaglomerular complex cell true juxtaglomerulus cell GO:0072052 KUPO:0001091 cell kidney cortex interstitial cell true KUPO:0001092 cell kidney medulla interstitial cell true true KUPO:0001101 cell kidney interstitial myofibroblast KUPO:0001102 cell kidney interstitial fibroblast KUPO:0001103 cell kidney interstitial fibrocyte KUPO:0001106 cell kidney interstitial alternatively activated macrophage KUPO:0001107 cell kidney interstitial inflammatory macrophage KUPO:0001108 cell kidney interstitial suppressor macrophage KUPO:0001109 cell kidney resident macrophage KUPO:0001110 cell kidney resident dendritic cell KUPO:0001113 cell kidney pelvis smooth muscle cell true KUPO:0001114 cell kidney pelvis urothelial cell true true KUPO:0001117 cell ureter urothelial cell true true KUPO:0001119 cell ureter adventitial cell true KUPO:0001130 cell kidney cortex collecting duct principal cell true KUPO:0001131 cell kidney cortex collecting duct intercalated cell true KUPO:0001132 cell kidney outer medulla collecting duct principal cell true KUPO:0001133 cell kidney outer medulla collecting duct intercalated cell true KUPO:0001134 cell kidney inner medulla collecting duct principal cell true KUPO:0001135 cell kidney inner medulla collecting duct intercalated cell true KUPO:0001136 cell kidney papillary duct intercalated cell true KUPO:0001137 cell kidney papillary duct principal cell true Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. KUPO:0001032 intraglomerular mesangial cell cell glomerular mesangial cell Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. Wikipedia:Intraglomerular_mesangial_cell intraglomerular mesangial cell CL:cjm KUPO:0001036 cell glomerular cell true KUPO:0001058 cell kidney connecting tubule epithelial cell true KUPO:0001093 cell kidney inner medulla interstitial cell true true KUPO:0001094 cell kidney outer medulla interstitial cell true true KUPO:0001045 cell kidney proximal convoluted tubule epithelial cell true KUPO:0001046 cell kidney proximal straight tubule epithelial cell true true KUPO:0001056 cell kidney distal convoluted tubule epithelial cell true KUPO:0001057 cell macula densa epithelial cell true true KUPO:0001014 cell kidney blood vessel cell true KUPO:0001029 cell kidney arterial blood vessel cell true KUPO:0001030 cell kidney capillary endothelial cell KUPO:0001031 cell kidney venous blood vessel cell true KUPO:0001047 cell kidney loop of Henle epithelial cell true KUPO:0001118 cell ureter smooth muscle cell true true KUPO:0001037 cell glomerular capillary endothelial cell true KUPO:0001038 cell kidney afferent arteriole cell true KUPO:0001041 cell kidney efferent arteriole cell true KUPO:0001048 cell kidney loop of Henle ascending limb epithelial cell true KUPO:0001053 cell kidney loop of Henle descending limb epithelial cell true KUPO:0001065 cell peritubular capillary endothelial cell true KUPO:0001068 cell vasa recta cell true KUPO:0001077 cell kidney cortex artery cell true KUPO:0001084 cell kidney cortex vein cell true KUPO:0001096 cell Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure. kidney artery smooth muscle cell KUPO:0001098 cell Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure. kidney arteriole smooth muscle cell KUPO:0001100 cell Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure. kidney venous system smooth muscle cell KUPO:0001039 cell kidney afferent arteriole endothelial cell true KUPO:0001040 cell kidney afferent arteriole smooth muscle cell KUPO:0001042 cell kidney efferent arteriole endothelial cell true KUPO:0001043 cell kidney efferent arteriole smooth muscle cell KUPO:0001049 cell kidney loop of Henle thick ascending limb epithelial cell true KUPO:0001050 cell kidney loop of Henle thin ascending limb epithelial cell true KUPO:0001051 cell kidney loop of Henle medullary thick ascending limb epithelial cell true KUPO:0001052 cell kidney loop of Henle cortical thick ascending limb epithelial cell KUPO:0001054 cell kidney loop of Henle thin descending limb epithelial cell true KUPO:0001066 cell kidney outer medulla peritubular capillary cell true true KUPO:0001067 cell kidney cortex peritubular capillary cell true KUPO:0001069 cell inner renal medulla vasa recta cell true true KUPO:0001070 cell outer renal medulla vasa recta cell true true KUPO:0001074 cell vasa recta ascending limb cell true KUPO:0001078 cell arcuate artery cell true KUPO:0001081 cell interlobular artery cell true KUPO:0001085 cell arcuate vein cell true KUPO:0001088 cell interlobular vein cell true KUPO:0001075 cell inner medulla vasa recta ascending limb cell true true KUPO:0001076 cell outer medulla vasa recta ascending limb cell true true KUPO:0001079 cell arcuate artery endothelial cell true KUPO:0001080 cell arcuate artery smooth muscle cell KUPO:0001082 cell interlobulary artery endothelial cell KUPO:0001083 cell interlobulary artery smooth muscle cell KUPO:0001086 cell arcuate vein endothelial cell KUPO:0001087 cell arcuate vein smooth muscle cell KUPO:0001089 cell interlobulary vein endothelial cell KUPO:0001090 cell interlobulary vein smooth muscle cell KUPO:0001012 Wikipedia:Kidney_collecting_duct_cell cell kidney collecting duct cell KUPO:0001071 cell vasa recta descending limb cell true KUPO:0001072 cell inner medulla vasa recta descending limb cell true true KUPO:0001073 cell outer medulla vasa recta descending limb cell true true KUPO:0001104 cell renal interstitial pericyte true KUPO:0001120 cell bladder cell KUPO:0001123 cell urethra cell KUPO:0001121 cell bladder urothelial cell true true KUPO:0001124 cell urethra urothelial cell true KUPO:0001128 cell kidney collecting duct principal cell true KUPO:0001129 http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells cell kidney collecting duct intercalated cell true An epithelial cell of the exocrine pancreas. FMA:70986 exocrine pancreas cell cell epithelial cell of exocrine pancreas An epithelial cell of the exocrine pancreas. GOC:tfm A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons cl olfactory bulb interneuron A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons PMID:18603310 the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter BTO:0003796 NIFSTD:nifext_122 glomerular layer cell olfactory bulb (accessory) glomerular layer cell olfactory bulb glomerular layer cell olfactory bulb glomerularal cell periglomerular cell cl periglomerular cell the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter MP:0009943 glomerular layer cell NIFSTD:nifext_122 olfactory bulb (accessory) glomerular layer cell NIFSTD:nifext_122 olfactory bulb glomerular layer cell NIFSTD:nifext_122 olfactory bulb glomerularal cell MP:0009943 periglomerular cell NIFSTD:nifext_122 the subcutaneous mechanoreceptors that innervate tylotrich hair follicles cl hair-tylotrich neuron the subcutaneous mechanoreceptors that innervate tylotrich hair follicles MP:0000977 the subcutaneous mechanoreceptors that innervate vellus hairs cl hair-down neuron the subcutaneous mechanoreceptors that innervate vellus hairs MP:0000979 A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord. proprioceptive neuron cl sensory neuron of dorsal root ganglion true A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord. MP:0004297 proprioceptive neuron MP:0004297 the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus BTO:0004778 striatal medium spiny neuron cl medium-sized densely spiny neuron medium spiny neuron the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus MP:0008462 striatal medium spiny neuron GO:0021773 medium-sized densely spiny neuron BTO:0004778 the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex cl mitral cell the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex MP:0009954 the principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala cl olfactory bulb tufted cell the principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala MP:0009955 the secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system parvocellular neuron parvocellular neurosecretory neuron cl parvocellular neurosecretory cell the secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system MP:0010125 the neurons that utilize glycine as a neurotransmitter cl glycinergic neuron the neurons that utilize glycine as a neurotransmitter MP:0010385 the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract cl intestinal enteroendocrine cell the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract MP:0010802 the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach cl stomach enteroendocrine cell the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach MP:0010803 chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals cl vomeronasal sensory neuron chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals MP:0011679 a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury. cl bronchioalveolar stem cells a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury. MP:0011691 cl endothelial cell of lung pulmonary vessel endothelial cell lung endothelial cell BTO:0001141 cl PAEC cell pulmonary artery endothelial cell PAEC cell BTO:0001141 An interneuron of the hippocampus. FMA:84777 cl hippocampal interneuron An interneuron of the hippocampus. GOC:pr A pyramidal neuron of the hippocampus. NIFSTD:sao131261273 SAO:sao131261273 hippocampus (CA) pyramidal cell hippocampus (CA) pyramidal neuron cl hippocampal pyramidal neuron A pyramidal neuron of the hippocampus. GOC:pr PMID:19342486 hippocampus (CA) pyramidal cell NIFSTD:sao131261273 hippocampus (CA) pyramidal neuron NIFSTD:sao131261273 Vascular endothelium found in colon blood vessels. CALOHA:TS-2397 colon endothelial cells colonic endothelial cell colon endothelial cell Vascular endothelium found in colon blood vessels. NPX:PDR colon endothelial cells CALOHA:TS-2397 colonic endothelial cell CALOHA:TS-2397 Cell of the nasopharyngeal epithelium. CALOHA:TS-2398 nasopharynx respiratory epithelial cells nasopharyngeal epithelial cell Cell of the nasopharyngeal epithelium. NPX:PDR nasopharynx respiratory epithelial cells CALOHA:TS-2398 Squamous cell of uterine cervix epithelium. CALOHA:TS-1251 cervix squamous cell cervix squamous epithelial cell cervix, uterine squamous epithelial cells uterine cervix squamous epithelial cell uterine cervix squamous epithelial cells uterine cervix squamous cell Squamous cell of uterine cervix epithelium. NPX:PDR cervix squamous cell CALOHA:TS-1251 cervix squamous epithelial cell CALOHA:TS-1251 cervix, uterine squamous epithelial cells CALOHA:TS-1251 uterine cervix squamous epithelial cell CALOHA:TS-1251 uterine cervix squamous epithelial cells CALOHA:TS-1251 Squamous cell of oral epithelium. CALOHA:TS-1252 oral cavity mucosa squamous cell oral cavity mucosa squamous epithelial cell oral mucosa squamous epithelial cell oral mucosa squamous epithelial cells oral mucosa squamous cell Squamous cell of oral epithelium. NPX:PDR oral cavity mucosa squamous cell CALOHA:TS-1252 oral cavity mucosa squamous epithelial cell CALOHA:TS-1252 oral mucosa squamous epithelial cell CALOHA:TS-1252 oral mucosa squamous epithelial cells CALOHA:TS-1252 Squamous cell of tonsil epithelium. CALOHA:TS-1253 tonsil squamous epithelial cell tonsil squamous epithelial cells tonsillar squamous cell tonsillar squamous epithelial cell tonsil squamous cell Squamous cell of tonsil epithelium. NPX:PDR tonsil squamous epithelial cell CALOHA:TS-1253 tonsil squamous epithelial cells CALOHA:TS-1253 tonsillar squamous cell CALOHA:TS-1253 tonsillar squamous epithelial cell CALOHA:TS-1253 Squamous cell of vaginal epithelium. CALOHA:TS-1254 vagina squamous epithelial cell vagina squamous epithelial cells vaginal squamous cell vaginal squamous epithelial cell vagina squamous cell Squamous cell of vaginal epithelium. NPX:PDR vagina squamous epithelial cell CALOHA:TS-1254 vagina squamous epithelial cells CALOHA:TS-1254 vaginal squamous cell CALOHA:TS-1254 vaginal squamous epithelial cell CALOHA:TS-1254 Glial cell of cerebral cortex. CALOHA:TS-1256 brain cortex glial cell cerebral cortex glial cells cerebrum cortex glial cell cerebral cortex glial cell Glial cell of cerebral cortex. NPX:PDR brain cortex glial cell CALOHA:TS-1256 cerebral cortex glial cells CALOHA:TS-1256 cerebrum cortex glial cell CALOHA:TS-1256 Glial cell of hippocampus. CALOHA:TS-1257 hippocampal glial cell hippocampus glial cells hippocampus neuroglial cell hippocampus glial cell Glial cell of hippocampus. NPX:PDR hippocampal glial cell CALOHA:TS-1257 hippocampus glial cells CALOHA:TS-1257 hippocampus neuroglial cell CALOHA:TS-1257 Glial cell of lateral ventricle. CALOHA:TS-1258 lateral ventricle glial cells lateral ventricle glial cell Glial cell of lateral ventricle. NPX:PDR lateral ventricle glial cells CALOHA:TS-1258 Neuron of lateral ventricle. CALOHA:TS-1261 lateral ventricle neural cell lateral ventricle neuronal cell lateral ventricle neuronal cells lateral ventricle neuron Neuron of lateral ventricle. NPX:PDR lateral ventricle neural cell CALOHA:TS-1261 lateral ventricle neuronal cell CALOHA:TS-1261 lateral ventricle neuronal cells CALOHA:TS-1261 OBSOLETE: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma. CL:0002617 breast adipocytes obsolete breast adipocyte true OBSOLETE: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma. HPA:Breast breast adipocytes CALOHA:TS-2377 Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. CALOHA:TS-1271 appendix glandular cells caecal appendix glandular cell cecal appendix glandular cell vermiform appendix glandular cell appendix glandular cell Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. NPX:PDR appendix glandular cells CALOHA:TS-1271 caecal appendix glandular cell CALOHA:TS-1271 cecal appendix glandular cell CALOHA:TS-1271 vermiform appendix glandular cell CALOHA:TS-1271 Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts. CALOHA:TS-1272 breast glandular cell breast glandular cells mammary glandular cell mammary gland glandular cell Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts. NPX:PDR;HPA:HPA breast glandular cell CALOHA:TS-1272 breast glandular cells CALOHA:TS-1272 mammary glandular cell CALOHA:TS-1272 Glandular cell of uterine cervix epithelium. CALOHA:TS-1273 cervix glandular cell cervix, uterine glandular cell cervix, uterine glandular cells uterine cervix glandular cell Glandular cell of uterine cervix epithelium. NPX:PDR cervix glandular cell CALOHA:TS-1273 cervix, uterine glandular cell CALOHA:TS-1273 cervix, uterine glandular cells CALOHA:TS-1273 Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. CALOHA:TS-1274 colon glandular cells colon glandular cell Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. NPX:PDR colon glandular cells CALOHA:TS-1274 Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. CALOHA:TS-1275 duodenum glandular cells duodenum glandular cell Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. NPX:PDR duodenum glandular cells CALOHA:TS-1275 Glandular cell of epididymal epithelium. CALOHA:TS-1276 epididymal glandular cell epididymis glandular cells epididymis glandular cell Glandular cell of epididymal epithelium. NPX:PDR epididymal glandular cell CALOHA:TS-1276 epididymis glandular cells CALOHA:TS-1276 Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells. CALOHA:TS-1277 fallopian tube glandular cell fallopian tube glandular cells uterine tube glandular cell oviduct glandular cell Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells. NPX:PDR;HPA:HPA fallopian tube glandular cell CALOHA:TS-1277 fallopian tube glandular cells CALOHA:TS-1277 uterine tube glandular cell CALOHA:TS-1277 Glandular cell of gall bladder epithelium. CALOHA:TS-1278 gall bladder glandular cells gallbladder glandular cell gallbladder glandular cells gall bladder glandular cell Glandular cell of gall bladder epithelium. NPX:PDR gall bladder glandular cells CALOHA:TS-1278 gallbladder glandular cell CALOHA:TS-1278 gallbladder glandular cells CALOHA:TS-1278 Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells. CALOHA:TS-1279 parathyroid gland glandular cell parathyroid gland glandular cells parathyroid glandular cell Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells. NPX:PDR;HPA:HPA parathyroid gland glandular cell CALOHA:TS-1279 parathyroid gland glandular cells CALOHA:TS-1279 Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. CALOHA:TS-1281 rectal glandular cell rectum glandular cells rectum glandular cell Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. NPX:PDR rectal glandular cell CALOHA:TS-1281 rectum glandular cells CALOHA:TS-1281 Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts. CALOHA:TS-1282 salivary gland glandular cells salivary gland glandular cell Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts. NPX:PDR;HPA:HPA salivary gland glandular cells CALOHA:TS-1282 Glandular cell of seminal vesicle epithelium. CALOHA:TS-1283 seminal vesicle glandular cells seminal vesicle glandular cell Glandular cell of seminal vesicle epithelium. NPX:PDR seminal vesicle glandular cells CALOHA:TS-1283 A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . CALOHA:TS-1286 FMA:86928 small bowel glandular cell small intestinal glandular cell small intestine glandular cells small intestine glandular cell A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . NCI_Thesaurus:Small_Intestinal_Glandular_Cell;NPX:PDR small bowel glandular cell CALOHA:TS-1286 small intestinal glandular cell CALOHA:TS-1286 small intestine glandular cells CALOHA:TS-1286 Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. BTO:0000028 CALOHA:TS-1242 exocrine pancreas glandular cell pancreas exocrine glandular cells pancreas exocrine glandular cell Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. NPX:PDR;HPA:HPA exocrine pancreas glandular cell CALOHA:TS-1242 pancreas exocrine glandular cells CALOHA:TS-1242 Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens. CALOHA:TS-2177 adrenal gland glandular cells adrenal glandular cell suprarenal gland glandular cell adrenal gland glandular cell Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens. NPX:PDR adrenal gland glandular cells CALOHA:TS-2177 adrenal glandular cell CALOHA:TS-2177 suprarenal gland glandular cell CALOHA:TS-2177 Endothelial cells forming the walls of the capillaries within the cerebral cortex. CALOHA:TS-2372 cerebral cortex endothelial cells endothelial cells of cerebral cortex cerebral cortex endothelial cell Endothelial cells forming the walls of the capillaries within the cerebral cortex. NPX:PDR cerebral cortex endothelial cells CALOHA:TS-2372 endothelial cells of cerebral cortex CALOHA:TS-2372 Circulating macrophages and tissue macrophages (alveolar macrophages) of lung. CALOHA:TS-0576 lung macrophages lung macrophage Circulating macrophages and tissue macrophages (alveolar macrophages) of lung. NPX:PDR;HPA:HPA lung macrophages CALOHA:TS-0576 Keratinocyte from foreskin. CALOHA:TS-0385 foreskin keratinocyte Keratinocyte from foreskin. NPX:PDR Chondrocyte forming the hyaline cartilage found in joints. CALOHA:TS-0056 articular chondrocyte Chondrocyte forming the hyaline cartilage found in joints. NPX:PDR Fibroblast from foreskin. CALOHA:TS-0384 BJ fibroblast foreskin fibroblast Fibroblast from foreskin. NPX:PDR Fibroblast from muscle organ. CALOHA:TS-0643 muscle fibroblast Fibroblast from muscle organ. NPX:PDR Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. CALOHA:TS-2109 bone marrow hematopoietic cells bone marrow poietic cells bone marrow hematopoietic cell Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. NPX:PDR bone marrow hematopoietic cells CALOHA:TS-2109 bone marrow poietic cells CALOHA:TS-2109 Neuron of the cerebellum. CALOHA:TS-2359 FMA:84665 cerebellum neuron cerebellar neuron Neuron of the cerebellum. NPX:PDR cerebellum neuron CALOHA:TS-2359 Any melanocyte that is part of a epidermis. TermGenie 2014-02-03T23:03:09Z cell CL:2000000 These cells are found primarily, but not exclusively, in primates including humans epidermal melanocyte Any melanocyte that is part of a epidermis. GOC:TermGenie A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. TermGenie 2014-02-11T17:29:04Z cell CL:2000001 peripheral blood mononuclear cell A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. GOC:TermGenie Any native cell that is part of a decidua. TermGenie 2014-02-20T23:06:41Z cell CL:2000002 decidua cell Any native cell that is part of a decidua. GOC:TermGenie Any cell that is part of a pituitary gland. TermGenie 2014-03-26T22:14:56Z cell CL:2000004 pituitary gland cell Any cell that is part of a pituitary gland. GOC:TermGenie Any macroglial cell that is part of a brain. TermGenie 2014-03-28T21:35:27Z cell CL:2000005 brain macroglial cell Any macroglial cell that is part of a brain. GOC:TermGenie Any germinal center B cell that is part of a tonsil. TermGenie 2014-03-28T21:35:33Z cell CL:2000006 tonsil germinal center B cell Any germinal center B cell that is part of a tonsil. GOC:TermGenie Chondrocyte forming the hyaline cartilage found in the knee joint. TermGenie 2014-06-04T14:40:11Z cell CL:2000007 articular chondrocyte of knee joint Chondrocyte forming the hyaline cartilage found in the knee joint. GOC:TermGenie Any blood vessel endothelial cell that is part of a microvascular endothelium. TermGenie 2014-06-04T15:07:42Z cell CL:2000008 microvascular endothelial cell Any blood vessel endothelial cell that is part of a microvascular endothelium. GOC:TermGenie Any blood vessel endothelial cell that is part of a microvascular endothelium. CL:2000008 TermGenie 2014-06-04T15:09:18Z cell CL:2000009 obsolete microvascular endothelium blood vessel endothelial cell true Any blood vessel endothelial cell that is part of a microvascular endothelium. GOC:TermGenie Any blood vessel endothelial cell that is part of a dermis. TermGenie 2014-06-04T15:12:06Z cell CL:2000010 dermis blood vessel endothelial cell Any blood vessel endothelial cell that is part of a dermis. GOC:TermGenie Any endothelial cell of lymphatic vessel that is part of a dermis. TermGenie 2014-06-04T15:15:08Z cell CL:2000011 dermis lymphatic vessel endothelial cell Any endothelial cell of lymphatic vessel that is part of a dermis. GOC:TermGenie Any skin fibroblast that is part of a pedal digit skin. TermGenie 2014-06-04T15:16:44Z cell CL:2000012 fibroblast of pedal digit skin Any skin fibroblast that is part of a pedal digit skin. GOC:TermGenie Any skin fibroblast that is part of a skin of abdomen. TermGenie 2014-06-04T15:18:16Z cell CL:2000013 fibroblast of skin of abdomen Any skin fibroblast that is part of a skin of abdomen. GOC:TermGenie Any skin fibroblast that is part of a upper leg skin. TermGenie 2014-06-04T15:19:44Z cell CL:2000014 fibroblast of upper leg skin Any skin fibroblast that is part of a upper leg skin. GOC:TermGenie Any skin fibroblast that is part of a arm. TermGenie 2014-06-04T15:29:06Z cell CL:2000015 fibroblast of arm Any skin fibroblast that is part of a arm. GOC:TermGenie Any lung endothelial cell that is part of a microvascular endothelium. TermGenie 2014-06-04T16:00:56Z cell CL:2000016 lung microvascular endothelial cell Any lung endothelial cell that is part of a microvascular endothelium. GOC:TermGenie Any fibroblast that is part of a periodontal ligament. TermGenie 2014-06-04T16:50:33Z cell CL:2000017 fibroblast of peridontal ligament Any fibroblast that is part of a periodontal ligament. GOC:TermGenie Any endothelial cell of artery that is part of a coronary artery. TermGenie 2014-06-04T17:08:47Z cell CL:2000018 endothelial cell of coronary artery Any endothelial cell of artery that is part of a coronary artery. GOC:TermGenie Any photoreceptor cell that is part of a compound eye. TermGenie 2014-06-24T23:16:45Z cell CL:2000019 compound eye photoreceptor cell Any photoreceptor cell that is part of a compound eye. GOC:TermGenie Any native cell that is part of a inner cell mass. TermGenie 2014-06-24T23:16:53Z cell CL:2000020 inner cell mass native cell Any native cell that is part of a inner cell mass. GOC:TermGenie Any native cell that is part of a sebaceous gland. TermGenie 2014-06-24T23:17:00Z cell CL:2000021 sebaceous gland native cell Any native cell that is part of a sebaceous gland. GOC:TermGenie Any native cell that is part of a cardiac septum. TermGenie 2014-06-24T23:17:07Z cell CL:2000022 cardiac septum native cell Any native cell that is part of a cardiac septum. GOC:TermGenie Any interneuron that is part of a spinal cord ventral column. TermGenie 2014-06-25T00:23:36Z cell CL:2000023 spinal cord ventral column interneuron Any interneuron that is part of a spinal cord ventral column. GOC:TermGenie Any neuron that is part of a spinal cord medial motor column. TermGenie 2014-06-25T00:23:43Z cell CL:2000024 spinal cord medial motor column neuron Any neuron that is part of a spinal cord medial motor column. GOC:TermGenie Any oligodendrocyte that is part of a spinal cord. TermGenie 2014-06-25T00:23:50Z cell CL:2000025 spinal cord oligodendrocyte Any oligodendrocyte that is part of a spinal cord. GOC:TermGenie Any Golgi cell that is part of a cerebellum. TermGenie 2014-06-25T00:23:57Z cell CL:2000026 obsolete cerebellum Golgi cell true Any Golgi cell that is part of a cerebellum. GOC:TermGenie Any basket cell that is part of a cerebellum. TermGenie 2014-06-25T00:24:03Z cell CL:2000027 cerebellum basket cell Any basket cell that is part of a cerebellum. GOC:TermGenie Any glutamatergic neuron that is part of a cerebellum. TermGenie 2014-06-25T00:24:10Z cell CL:2000028 cerebellum glutamatergic neuron Any glutamatergic neuron that is part of a cerebellum. GOC:TermGenie Any neuron that is part of a central nervous system. TermGenie 2014-06-25T01:17:43Z cell CL:2000029 central nervous system neuron Any neuron that is part of a central nervous system. GOC:TermGenie Any native cell that is part of a hypothalamus. TermGenie 2014-06-25T01:17:50Z cell CL:2000030 hypothalamus native cell Any native cell that is part of a hypothalamus. GOC:TermGenie Any neuron that is part of a lateral line ganglion. TermGenie 2014-06-25T01:17:57Z cell CL:2000031 lateral line ganglion neuron Any neuron that is part of a lateral line ganglion. GOC:TermGenie Any neuron that is part of a peripheral nervous system. TermGenie 2014-06-25T02:28:17Z cell CL:2000032 peripheral nervous system neuron Any neuron that is part of a peripheral nervous system. GOC:TermGenie Any basal cell of epidermis that is part of a limb. TermGenie 2014-06-25T02:28:25Z cell CL:2000033 limb basal cell of epidermis Any basal cell of epidermis that is part of a limb. GOC:TermGenie Any neuromast hair cell that is part of a anterior lateral line. TermGenie 2014-06-25T03:44:37Z cell CL:2000034 anterior lateral line neuromast hair cell Any neuromast hair cell that is part of a anterior lateral line. GOC:TermGenie Any neuromast mantle cell that is part of a anterior lateral line. TermGenie 2014-06-25T03:44:44Z cell CL:2000035 anterior lateral line neuromast mantle cell Any neuromast mantle cell that is part of a anterior lateral line. GOC:TermGenie Any neuromast support cell that is part of a anterior lateral line. TermGenie 2014-06-25T03:44:51Z cell CL:2000036 anterior lateral line neuromast support cell Any neuromast support cell that is part of a anterior lateral line. GOC:TermGenie Any neuromast hair cell that is part of a posterior lateral line. TermGenie 2014-06-25T03:44:57Z cell CL:2000037 posterior lateral line neuromast hair cell Any neuromast hair cell that is part of a posterior lateral line. GOC:TermGenie Any neuromast mantle cell that is part of a posterior lateral line. TermGenie 2014-06-25T03:45:04Z cell CL:2000038 posterior lateral line neuromast mantle cell Any neuromast mantle cell that is part of a posterior lateral line. GOC:TermGenie Any neuromast support cell that is part of a posterior lateral line. TermGenie 2014-06-25T03:45:11Z cell CL:2000039 posterior lateral line neuromast support cell Any neuromast support cell that is part of a posterior lateral line. GOC:TermGenie Any microvascular endothelial cell that is part of a urinary bladder. TermGenie 2014-07-09T00:04:47Z cell CL:2000040 bladder microvascular endothelial cell Any microvascular endothelial cell that is part of a urinary bladder. GOC:TermGenie Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium. TermGenie 2014-07-09T00:09:54Z cell CL:2000041 dermis microvascular lymphatic vessel endothelial cell Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium. GOC:TermGenie Any fibroblast that is part of a embryo. TermGenie 2014-07-09T00:12:00Z cell CL:2000042 embryonic fibroblast Any fibroblast that is part of a embryo. GOC:TermGenie Any pericyte cell that is part of a brain. TermGenie 2014-07-09T00:18:22Z cell CL:2000043 brain pericyte Any pericyte cell that is part of a brain. GOC:TermGenie Any microvascular endothelial cell that is part of a brain. TermGenie 2014-07-09T00:24:53Z cell CL:2000044 brain microvascular endothelial cell Any microvascular endothelial cell that is part of a brain. GOC:TermGenie Any melanocyte that is part of a prepuce of penis. TermGenie 2014-07-09T00:45:07Z cell CL:2000045 foreskin melanocyte Any melanocyte that is part of a prepuce of penis. GOC:TermGenie Any cardiac muscle cell that is part of a cardiac ventricle. TermGenie 2014-08-12T20:50:28Z cell CL:2000046 ventricular cardiac muscle cell Any cardiac muscle cell that is part of a cardiac ventricle. GOC:TermGenie Any motor neuron that is part of a brainstem. TermGenie 2014-10-02T23:52:53Z cell CL:2000047 brainstem motor neuron Any motor neuron that is part of a brainstem. GOC:TermGenie Any spinal cord motor neuron that is part of a ventral horn of spinal cord. TermGenie 2014-10-03T00:26:27Z cell CL:2000048 ventral horn of spinal cord spinal cord motor neuron Any spinal cord motor neuron that is part of a ventral horn of spinal cord. GOC:TermGenie Any pyramidal cell that is part of a primary motor cortex. TermGenie 2014-10-06T17:39:04Z cell CL:2000049 http://www.ncbi.nlm.nih.gov/pubmed/12524689 primary motor cortex pyramidal cell Any pyramidal cell that is part of a primary motor cortex. GOC:TermGenie Any retinal ganglion cell that is part of a retina. TermGenie 2014-10-06T17:43:59Z cell CL:2000050 http://www.ncbi.nlm.nih.gov/pubmed/2889210 obsolete retina retinal ganglion cell true Any retinal ganglion cell that is part of a retina. GOC:TermGenie Any fibroblast that is part of a spleen. TermGenie 2014-10-06T18:58:47Z cell CL:2000051 splenic fibroblast Any fibroblast that is part of a spleen. GOC:TermGenie Any endothelial cell of artery that is part of a umbilical cord. TermGenie 2014-10-06T19:01:48Z cell CL:2000052 http://www.sciencellonline.com/site/productInformation.php?keyword=8010 umbilical artery endothelial cell Any endothelial cell of artery that is part of a umbilical cord. GOC:TermGenie Any endothelial cell that is part of a spleen. TermGenie 2014-10-06T19:06:04Z cell CL:2000053 http://www.sciencellonline.com/site/productInformation.php?keyword=5500 splenic endothelial cell Any endothelial cell that is part of a spleen. GOC:TermGenie A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid. 2014-10-06T19:08:51Z cell CL:2000054 Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit. hepatic pit cell A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid. GOC:dos PMID:9408963 Any dendritic cell that is part of a liver. TermGenie 2014-10-06T19:16:11Z cell CL:2000055 http://www.jleukbio.org/content/66/2/322.abstract liver dendritic cell Any dendritic cell that is part of a liver. GOC:TermGenie Any pyramidal cell that is part of a regional part of cerebral cortex. TermGenie 2014-10-06T19:20:41Z cell CL:2000056 Meynert cell Any pyramidal cell that is part of a regional part of cerebral cortex. GOC:TermGenie Any osteoblast that is part of a femur. TermGenie 2014-10-06T19:29:45Z cell CL:2000057 http://www.sciencellonline.com/site/productInformation.php?keyword=4610 femural osteoblast Any osteoblast that is part of a femur. GOC:TermGenie Any osteoblast that is part of a skull. TermGenie 2014-10-06T19:48:30Z cell CL:2000058 http://www.sciencellonline.com/site/productInformation.php?keyword=4600 calvarial osteoblast Any osteoblast that is part of a skull. GOC:TermGenie Any microvascular endothelial cell that is part of a prostate gland. TermGenie 2014-10-07T17:46:27Z cell CL:2000059 http://www.sciencellonline.com/site/productInformation.php?keyword=4400 prostate gland microvascular endothelial cell Any microvascular endothelial cell that is part of a prostate gland. GOC:TermGenie Any trophoblast cell that is part of a placenta. TermGenie 2014-10-07T17:48:27Z cell CL:2000060 http://www.sciencellonline.com/site/productInformation.php?keyword=7120 placental villous trophoblast Any trophoblast cell that is part of a placenta. GOC:TermGenie Any mesenchymal stem cell that is part of a placenta. TermGenie 2014-10-07T17:51:11Z cell CL:2000061 http://www.sciencellonline.com/site/productInformation.php?keyword=7140 placental amniotic mesenchymal stromal cell Any mesenchymal stem cell that is part of a placenta. GOC:TermGenie Any capillary endothelial cell that is part of a placenta. TermGenie 2014-10-07T17:55:56Z cell CL:2000062 http://www.ncbi.nlm.nih.gov/books/NBK53245/ placental villus capillary endothelial cell Any capillary endothelial cell that is part of a placenta. GOC:TermGenie Any fibroblast that is part of a female gonad. TermGenie 2014-10-07T17:57:42Z cell CL:2000063 http://www.sciencellonline.com/site/productInformation.php?keyword=7330 ovarian fibroblast Any fibroblast that is part of a female gonad. GOC:TermGenie Any epithelial cell that is part of a female gonad. TermGenie 2014-10-07T17:59:13Z cell CL:2000064 http://www.sciencellonline.com/site/productInformation.php?keyword=7310 ovarian surface epithelial cell Any epithelial cell that is part of a female gonad. GOC:TermGenie Any microvascular endothelial cell that is part of a female urethra. TermGenie 2014-10-07T18:18:01Z cell CL:2000065 http://www.sciencellonline.com/site/productInformation.php?keyword=7300 ovarian microvascular endothelial cell Any microvascular endothelial cell that is part of a female urethra. GOC:TermGenie Any fibroblast that is part of a cardiac ventricle. TermGenie 2014-10-07T18:35:38Z cell CL:2000066 http://www.sciencellonline.com/site/productInformation.php?keyword=6310 cardiac ventricle fibroblast Any fibroblast that is part of a cardiac ventricle. GOC:TermGenie Any fibroblast that is part of a cardiac atrium. TermGenie 2014-10-07T18:36:54Z cell CL:2000067 http://www.sciencellonline.com/site/productInformation.php?keyword=6320 cardiac atrium fibroblast Any fibroblast that is part of a cardiac atrium. GOC:TermGenie Any fibroblast that is part of a pericardium. TermGenie 2014-10-07T18:38:06Z cell CL:2000068 http://www.sciencellonline.com/site/productInformation.php?keyword=6430 pericardium fibroblast Any fibroblast that is part of a pericardium. GOC:TermGenie Any fibroblast that is part of a gallbladder. TermGenie 2014-10-07T18:41:43Z cell CL:2000069 http://www.sciencellonline.com/site/productInformation.php?keyword=5430 gallbladder fibroblast Any fibroblast that is part of a gallbladder. GOC:TermGenie Any fibroblast that is part of a optic choroid. TermGenie 2014-10-07T18:50:43Z cell CL:2000070 http://www.sciencellonline.com/site/productInformation.php?keyword=6620 optic choroid fibroblast Any fibroblast that is part of a optic choroid. GOC:TermGenie Any microvascular endothelial cell that is part of a breast. TermGenie 2014-10-07T19:55:30Z cell CL:2000071 http://www.sciencellonline.com/site/productInformation.php?keyword=7600 mammary microvascular endothelial cell Any microvascular endothelial cell that is part of a breast. GOC:TermGenie Any microvascular endothelial cell that is part of a adipose tissue. TermGenie 2014-10-07T22:13:45Z cell CL:2000072 http://www.sciencellonline.com/site/productInformation.php?keyword=7200 adipose microvascular endothelial cell Any microvascular endothelial cell that is part of a adipose tissue. GOC:TermGenie Any migratory neural crest cell that is part of a cardiac neural crest. TermGenie 2014-11-05T01:18:43Z cell CL:2000073 migratory cardiac neural crest cell Any migratory neural crest cell that is part of a cardiac neural crest. GOC:TermGenie Any leukocyte that is part of a spleen. TermGenie 2014-11-05T01:26:50Z cell CL:2000074 Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. splenocyte Any leukocyte that is part of a spleen. GOC:TermGenie Any endodermal cell that is part of a anterior visceral endoderm. TermGenie 2014-11-05T01:34:13Z cell CL:2000075 anterior visceral endoderm cell Any endodermal cell that is part of a anterior visceral endoderm. GOC:TermGenie Any vein endothelial cell that is part of a hindlimb stylopod. TermGenie 2014-12-02T18:40:47Z cell CL:2000076 hindlimb stylopod vein endothelial cell Any vein endothelial cell that is part of a hindlimb stylopod. GOC:TermGenie Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major. TermGenie 2014-12-02T18:48:17Z cell CL:2000077 skeletal muscle tissue of pectoralis major striated muscle cell Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major. GOC:TermGenie Any pericyte cell that is part of a placenta. TermGenie 2014-12-02T18:51:03Z cell CL:2000078 placental pericyte Any pericyte cell that is part of a placenta. GOC:TermGenie Any mesenchymal stem cell of the bone marrow that is part of a femur. TermGenie 2014-12-02T19:07:31Z cell CL:2000079 mesenchymal stem cell of femoral bone marrow Any mesenchymal stem cell of the bone marrow that is part of a femur. GOC:TermGenie Any mesenchymal stem cell of adipose that is part of a abdomen. TermGenie 2014-12-02T19:10:34Z cell CL:2000080 mesenchymal stem cell of abdominal adipose Any mesenchymal stem cell of adipose that is part of a abdomen. GOC:TermGenie Any melanocyte of skin that is part of a skin of face. TermGenie 2014-12-02T19:10:40Z cell CL:2000081 melanocyte of skin of face Any melanocyte of skin that is part of a skin of face. GOC:TermGenie Any melanocyte of skin that is part of a skin of prepuce of penis. TermGenie 2014-12-02T19:10:45Z cell CL:2000082 melanocyte of foreskin Any melanocyte of skin that is part of a skin of prepuce of penis. GOC:TermGenie Any hair follicle dermal papilla cell that is part of a scalp. TermGenie 2014-12-02T19:10:50Z cell CL:2000083 hair follicle dermal papilla cell of scalp Any hair follicle dermal papilla cell that is part of a scalp. GOC:TermGenie Any goblet cell that is part of a conjunctiva. TermGenie 2014-12-02T19:28:38Z cell CL:2000084 conjunctiva goblet cell Any goblet cell that is part of a conjunctiva. GOC:TermGenie Any mononuclear cell that is part of a umbilical cord. TermGenie 2014-12-02T20:14:16Z cell CL:2000085 mononuclear cell of umbilical cord Any mononuclear cell that is part of a umbilical cord. GOC:TermGenie Any basket cell that is part of a neocortex. TermGenie 2014-12-24T00:37:19Z cell CL:2000086 neocortex basket cell Any basket cell that is part of a neocortex. GOC:TermGenie Any basket cell that is part of a dentate gyrus of hippocampal formation. TermGenie 2014-12-24T00:37:24Z cell CL:2000087 dentate gyrus of hippocampal formation basket cell Any basket cell that is part of a dentate gyrus of hippocampal formation. GOC:TermGenie Any basket cell that is part of a Ammon's horn. TermGenie 2014-12-24T00:37:30Z cell CL:2000088 Ammon's horn basket cell Any basket cell that is part of a Ammon's horn. GOC:TermGenie The principal cell type of the dentate gyrus. TermGenie 2015-02-23T05:48:23Z cell CL:2000089 The granule cell has a characteristic cone-shaped tree of spiny apical dendrites. dentate gyrus of hippocampal formation granule cell The principal cell type of the dentate gyrus. GOC:TermGenie Any stellate cell that is part of a dentate gyrus of hippocampal formation. TermGenie 2015-02-23T05:48:40Z cell CL:2000090 dentate gyrus of hippocampal formation stellate cell Any stellate cell that is part of a dentate gyrus of hippocampal formation. GOC:TermGenie Any microvascular endothelial cell that is part of a endometrial blood vessel. TermGenie 2015-03-31T21:02:36Z cell CL:2000091 endometrial microvascular endothelial cells Any microvascular endothelial cell that is part of a endometrial blood vessel. GOC:TermGenie Any keratinocyte that is part of a hair follicle. TermGenie 2015-03-31T21:07:02Z cell CL:2000092 hair follicular keratinocyte Any keratinocyte that is part of a hair follicle. GOC:TermGenie Any fibroblast of lung that is part of a bronchus. TermGenie 2015-03-31T21:16:22Z cell CL:2000093 bronchus fibroblast of lung Any fibroblast of lung that is part of a bronchus. GOC:TermGenie Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium. TermGenie 2015-03-31T22:25:17Z cell CL:2000094 nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium. GOC:TermGenie Any hematopoietic stem cell that is part of a umbilical cord blood. TermGenie 2015-05-26T18:58:34Z cell CL:2000095 cord blood hematopoietic stem cell Any hematopoietic stem cell that is part of a umbilical cord blood. GOC:TermGenie Any fibroblast that is part of a reticular layer of dermis. TermGenie 2015-08-11T16:28:16Z cell CL:2000096 reticular layer of dermis fibroblast Any fibroblast that is part of a reticular layer of dermis. GOC:TermGenie Any dopaminergic neuron that is part of a midbrain. TermGenie 2015-12-03T16:42:40Z cell CL:2000097 midbrain dopaminergic neuron Any dopaminergic neuron that is part of a midbrain. GOC:TermGenie Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions. tmeehan 2010-05-25T01:36:34Z cell neutrophillic cytoplasm Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions. GOC:tfm Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. tmeehan 2009-12-22T03:54:43Z cell lobed nucleus Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. GOC:tfm Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions. tmeehan 2009-12-22T04:23:25Z eosinophilic cell acidophilic cytoplasm Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions. GOC:tfm Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. tmeehan 2009-12-22T04:24:54Z cell basophilic cytoplasm Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. GOC:tfm Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. tmeehan 2009-12-28T04:25:23Z cell polychromatophilic cytoplasm Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. GOC:tfm A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell. tmeehan 2009-12-23T10:53:24Z cell increased nucleus size A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell. GOC:tfm A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament. tmeehan 2009-12-23T02:18:43Z cell banded nucleus A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament. GOC:tfm A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin. tmeehan 2009-12-23T02:31:25Z cell reniform nucleus A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin. GOC:tfm Heterochromatin that is arranged in a carthwheel pattern. tmeehan 2009-12-28T04:28:35Z cell cartwheel heterochromatin Heterochromatin that is arranged in a carthwheel pattern. GOC:tfm alobate nucleus interleukin-5 production To be added to GO structure abnormal neoplastic neoplastic, malignant