Adrien Barton Arnaud Rosier Jean-François Ethier Paul Fabry http://creativecommons.org/licenses/by/4.0/ Cardio Vascular Disease Ontology CVDO is an ontology of cardiovascular diseases structured on OBO foundry’s principle and based on BFO. CVDO reorganizes and completes DOID cardiovascular diseases following OGMS tripartite model of disease, and builds its taxonomy of diseases largely by automatic reasoning. 2020-03-05 This annotation property is created temporarily for better visibility of the distinction between DOID definitions and updated CVDO definition (when a DOID definition of a class did not need to be changed, no additional CVDO definition was included). Ultimately, 'CVDO definition' annotation properties should be replaced by 'definition' annotation properties. CVDO definition This annotation property is created temporarily for better visibility of the CVDO notes, in particular those that concern DOID classes. Ultimately, 'CVDO editor note' annotation properties should be replaced by 'editor note' annotation properties, or removed. CVDO editor note CVDO adds the property chain that if A occurs_in B and B located_in_at_all_times C, then A occurs_in C. This is used for a few inferences in the ontology, but CVDO can be used without problem without this property chain. An endocarditis caused by bacterial infection. bacterial endocarditis An endocarditis caused by viral infection. viral endocarditis An endocarditis caused by fungal infection. fungal endocarditis A disorder located in the heart. heart disorder A disorder always located in a blood vessel. vascular disorder A disorder always located in the endocardium. endocardium disorder A disorder always located in the pericardium. Since the pericardium is not a part of the heart according to FMA, pericardium disorder is not classified as a heart disorder. pericardium disorder A pericarditis caused by an infection. infectious pericarditis A pericarditis caused by a bacterial infection. bacterial pericarditis A pericarditis caused by a viral infection. viral pericarditis A pericarditis caused by a fungal infection. fungal pericarditis protozoal pericarditis A pathological process involving or occuring in the heart. heart pathological process A pathological process involving or occuring in the pericardium. pericardium pathological process A pericarditis that has an acute disease course. acute pericarditis A pericarditis that has a chronic disease course. chronic pericarditis atrioventricular block (disease) first degree atrioventricular block (disease) Mobitz I second degree atrioventricular block (disease) complete heart block third degree atrioventricular block (disease) A disorder always loacted in the conducting tissue of the heart. heart conduction disorder impaired atrioventricular node impaired right branch of atrioventricular bundle bundle of Kent sinoatrial block (disease) Wenckebach block Mobitz I second degree sinoatrial block (disease) sinus exit block Mobitz II second degree sinoatrial block (disease) first degree sinoatrial block (disease) third degree sinoatrial block (disease) impaired sinoatrial node heart block (disease) impaired posterior division of left branch of atrioventricular bundle left posterior fascicular block (disease) infra-hisian block (disease) left bundle branch block (disease) A heart conduction disease characterized by cardiac arrhythmia processes. Usual medical language does not differentiate the disease and the corresponding pathological process for the different kinds of cardiac arrhythmias. CVDO distinguishes them explicitly with the suffix '(disease)' or '(process)'. cardiac arrhythmia (disease) atrial fibrillation (disease) atrial fibrillation (process) atrial flutter (disease) cavotricuspid isthmus dependant macroreentry tachycardia type I atrial flutter common atrial flutter (disease) A pathological process of fibrosis of the cardiac atrium. cardiac atrium fibrosis supraventricular tachycardia (process) bradycardia (disease) bradycardia (process) premature atrial contraction (disease) left anterior fascicle A disorder always located in a heart valve. heart valve disorder wandering pacemaker A disease affecting the tricuspid valve of the heart. tricuspid valve disease A degenerated structure in a mitral valve leaflet due to myxomatous proliferation. myxomatous degenerated structure in a mitral valve leaflet A heart pathological process that has a heart valve as a participant. This class should not be confused with 'heart valve pathological process', which are pathological processes occurring in a heart valve, rather than pathological process having as participant a heart valve. heart pathological process involving a heart valve mitral valve leaflet displacement into the left atrium during left ventricular systole tricuspid valve leaflet displacement into the right atrium during right ventricular systole aortic valve leaflet displacement into the left ventricle during left ventricular diastole heart valve leaflet displacement into a cardiac chamber during ventricular systole mitral valve improper close during left ventricular systole retrograd blood flow through mitral valve during left ventricular systole retrograd blood flow through pulmonary valve during right ventricular diastole pulmonary valve improper close during right ventricular diastole tricuspid valve improper close during right ventricular systole aortic valve improper close during left ventricular diastole retrograd blood flow through tricuspid valve during right ventricular systole retrograd blood flow through aortic valve during left ventricular diastole disturbed anterograd blood flow through mitral valve during left ventricular diastole retrograd blood flow through a heart valve disturbed anterograd blood flow through a heart valve disturbed anterograd blood flow through tricuspid valve during right ventricular diastole disturbed anterograd blood flow through pulmonary valve during right ventricular systole disturbed anterograd blood flow through aortic valve during left ventricular systole A disease in which some disorder of a heart valve prevents it from opening properly, occasioning disturbance in the anterograd blood flow through the valve. heart valve stenosis impaired cardiac output pressure blood pressure A pathological process of highly pressured aerterial blood flow. highly pressured arterial blood flow A disease in which an abnormal structure in a heart valve prevents it to close propertly, occasioning a retrograd blood flow through the valve. heart valve insufficiency A pathological process of a heart valve closing improperly. heart valve improper close A disorder always located in a vein. vein disorder A pathological process involving or occuring in a blood vessel. vascular pathological process A pathological process of formation of a blood clot inside a blood vessel, obstructing the flow of blood. thrombosis A thrombosis occurring in a deep vein. deep vein thrombosis A pathological process of an artery hardening. artery hardening A pathological process of formation of atheromous plaques in an artery. atheromous plaque formation in artery A pathological process of lodging of an embolus in a blood vessel. embolism A disorder of localized, blood-filled balloon-like bulge in the wall of a blood vessel. aneurysm (disorder) ischemic disease compression disease An atrial fibrillation disease that is characterized by an atrial fibrillation episode longer than 7 days which does not terminate by cardioversion. permanent atrial fibrillation A pathological process of dilatation of the myocardium of a right cardiac ventricle. right ventricular myocardium dilatation A pathological process of an aneurysm rupturing. aneurysm rupture A disorder always located in the mycoardium. myocardium disorder A cardiomyopathy whose etiological process includes a stressful or emotional situation, characterized by transient ventricular apical wall motion abnormalities (ballooning). Tako-Tsubo cardiomyopathy is not a dilated cardiomyopathy in Elliott et al.'s (2008) classification. Tako Tsubo cardiomyopathy "A cardiomyopathy characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. The myocardial wall is often thickened with a thin, compacted epicardial layer and a thickened endocardial layer." (Elliott et al., 2008) noncompaction cardiomyopathy left ventricular noncompaction A hypertrophic cardiomyopathy that has a genetic origin. genetic hypertrophic cardiomyopathy A disease affecting the pericardium. Since pericardium is not a part of heart according to FMA, pericardium disease is not classified as a heart disease. pericardium disease This is a dummy class not intended to be included in CVDO's final version, used to store temporarily DOID's vascular diseases that may be reclassified in the future. vascular disease - unclassified by CVDO A pathological process occuring in a cardiac atrium. cardiac atrium pathological process A pathological process occurring in a cardiac ventricle. cardiac ventricle pathological process A pathological process constituted by a thrombosis (creating a blood clot) and a subsequent embolism (involving the blood clot as the embolus). thromboembolism A necrosis of a tissue caused by a local lack of oxygen, due to an obstruction of the tissue's blood supply. infarction pulmonary valve leaflet displacement into the right ventricle during right ventricular diastole A pathological process involving the blood circuation in the heart. cardiac blood circulation pathological process A pathological process involving the blood circulation in a blood vessel. vascular blood circulation pathological process part of atrial myocardium with impaired conduction diabetic microangiopathy diabetic macroangiopathy A pathological process consisting in the formation of atheromous plaques in a coronary artery. It may lead to a coronary stenosis. atheromous plaque formation in coronary artery A coronary heart disease due to a coronary stenosis. atherosclerotic coronary heart disease A pathological process of dilatation of the myocardium of a left cardiac ventricle. left ventricular myocardium dilatation supraventricular tachycardia (disease) left atrial flutter (disease) right atrial flutter (disease) junctional tachycardia (disease) atrioventricular nodal reentrant tachycardia (disease) atrial flutter (process) ventricular fibrillation (process) junctional tachycardia (process) premature atrial contraction (process) A pathological process involving the electrical activity of the heart. cardiac arrhythmia (process) heart block (process) atrioventricular block (process) infra-hisian block (process) sinoatrial block (process) Mobitz I second degree atrioventricular block (process) Mobitz II second degree atrioventricular block (process) first degree atrioventricular block (process) third degree atrioventricular block (process) left anterior fascicular block (process) left bundle branch block (process) left posterior fascicular block (process) right bundle branch block (process) Mobitz I second degree sinoatrial block (process) Mobitz II second degree sinoatrial block (process) first degree sinoatrial block (process) third degree sinoatrial block (process) A disorder always located in a coronary artery. coronary artery disorder A pathological process of dilatation of the myocardium of a cardiac ventricle. ventricular myocardium dilatation A pathological process of hypertrophy of the myocardium of a cardiac ventricle. ventricular myocardium hypertrophy A pathological process of hypertrophy of the myocardium of a left cardiac ventricle. left ventricular myocardium hypertrophy A pathological process of hypertrophy of the myocardium of a right cardiac ventricle. right ventricular myocardium hypertrophy A pathological process of an organ or part of organ getting inflamed. pathological inflammation process An inflammation process occurring in the myocardium. inflammation process in a myocardium An inflammation process occurring in the endocardium. inflammation process in an endocardium An inflammation process occurring in the pericardium. inflammation process in a pericardium An inflammation process occurring in the aorta. inflammation process in aorta An inflammation process in a blood vessel. inflammation process in a blood vessel An inflammation process occurring in the femoral vein. inflammation process in a femoral vein An inflammation process occurring in an iliac vein. inflammation process in an iliac vein An inflammation of the retinal artery. inflammation process in a retinal artery An inflammation process occurring in a vein. inflammation process in a vein A pathological process of fibrofatty replacement in the myocardium of the right cardiac ventricle. fibrofatty replacement in a right ventricular myocardium A disorder of degenerated structure in a heart valve leaflet. degenerated structure in a heart valve leaflet A disorder of degenerated structure in an aortic valve leaflet. degenerated structure in an aortic valve leaflet A disorder of degenerated structure in a mitral valve leaflet. degenerated structure in a mitral valve leaflet A (clinically abnormal) degenerated structure in a tricuspid valve leaflet. degenerated structure in a tricuspid valve leaflet A disorder of degenerated structure in a pulmonary valve leaflet. degenerated structure in a pulmonary valve leaflet A mitral valve prolapse due to myxomatous proliferation in the mitral valve. Barlow's syndrome A pathological process consisting in the abnormal accumulation of fluid in the pericardial cavity. A process of pericardial effusion leads to the disorder 'fluid in the pericardial cavity'. fluid accumulation in the pericardial cavity An ischemic cardiomyopathy due to coronary stenosis. atherosclerotic ischemic cardiomyopathy An atrial fibrillation disease that is characterized by an atrial fibrillation episode shorter than 7 days. paroxysmal atrial fibrillation An atrial fibrillation disease that is characterized by an atrial fibrillation episode longer than 7 days which does terminate by cardioversion. persistent atrial fibrillation premature contraction (process) premature junctional contraction (process) premature ventricular contraction (process) sinus pause sinoatrial arrest (process) sinus bradycardia (process) tachyarrhythmia (process) tachycardia (process) left atrial flutter (process) right atrial flutter (process) common atrial flutter (process) atrioventricular nodal reentrant tachycardia (process) ventricular tachycardia (process) monomorphic ventricular tachycardia (process) torsades de pointes (process) ventricular flutter (process) inappropriate sinus tachycardia (process) ventricular preexcitation (process) A pathological process of a coronary artery hardening. coronary artery hardening accessory bundle Accessory bundle that connects the atrium to a ventricle outside of the regular atrioventricular conduction system. atrioventricular accessory bundle impaired sinus node A sick sinus syndrome characterized by sinus pauses and/or bradycardia episodes alternating with sinus or atrial tachycardia episodes. tachycardia-bradycardia syndrome inappropriate sinus tachycardia (disease) A disease cause by a cardiac ion channel disorder. cardiac channelopathy A cardiac channelopathy in which delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsades de pointes. This is a rare disease. long QT syndrome A cardiac channelopathy that has a genetic origin. genetic cardiac channelopathy sinus bradycardia (disease) left bundle branch block (process) tachyarrhythmia (disease) tachycardia (disease) sinoatrial arrest (disease) atrioventricular reciprocating tachycardia (disease) ventricular tachycardia (disease) ventricular flutter (disease) torsades de pointes (disease) monomorphic ventricular tachycardia (disease) ventricular fibrillation (disease) ventricular tachyarrhythmia (process) atrioventricular reciprocating tachycardia (process) premature contraction (disease) premature junctional contraction (disease) premature ventricular contraction (disease) A pathological process occurring in a cardiac chamber. cardiac chamber pathological process A disorder always located in the mitral valve. mitral valve disorder A disorder always located in the aortic valve. aortic valve disorder A disorder always located in the tricuspid valve. tricuspid valve disorder A disorder always located in the pulmonary valve. pulmonary valve disorder A pathological process of a heart valve improper opening. heart valve improper opening aortic valve improper opening during left ventricular systole mitral valve narrowed opening during left ventricular diastole pulmonary valve narrowed opening during right ventricular systole tricuspid valve narrowed opening during right ventricular diastole A coronary heart disease leading to stable angina. coronary heart disease with stable angina An acute coronary syndrome due to coronary stenosis. atherosclerotic acute coronary syndrome A heart ischemia accompanied by pain. Angina pectoris is sometimes taken to refer to the pain itself, rather than to the pathological process behind it. angina pectoris An angina that is not unstable. stable angina pectoris An angina that worsens. It has at least one of these three features: 1. it occurs at rest (or with minimal exertion), usually lasting >10 min 2. it is severe and of new onset (i.e., within the prior 4–6 weeks) 3. it occurs with a crescendo pattern (i.e., distinctly more severe, prolonged, or frequent than before). unstable angina pectoris A heart pathological process that has a mitral valve as a participant. heart pathological process involving a mitral valve A heart pathological process that has an aortic valve as a participant. heart pathological process involving an aortic valve A heart pathological process that has a tricuspid valve as a participant. heart pathological process involving a tricuspid valve A heart pathological process that has a pulmonary valve as a participant. heart pathological process involving a pulmonary valve heart valve leaflet displacement into a cardiac chamber during ventricular diastole ventricular systole ventricular diastole atrial systole atrial diastole left ventricular diastole right ventricular diastole left ventricular systole right ventricular systole left atrial systole right atrial systole left atrial diastole right atrial diastole A pathological process of a heart valve being displaced into a cardiac chamber. heart valve leaflet displacement into a cardiac chamber A disorder of fluid in the pericardial cavity. fluid in the pericardial cavity A disorder of blood in the pericardial cavity. blood in the pericardial cavity heart conduction pathological process anomalous atrioventricular excitation (process) ventricular preexcitation (disease) A disorder in the heart conduction system that causes a disturbed function of ion channel subunits or the proteins that regulate them. cardiac ion channels disorder A disease characterized by the displacement of a degenerated pulmonary valve leaflet into the right ventricle during diastole. pulmonary valve prolapse impaired anterior division of left branch of atrioventricular bundle ventricular tachyarrhythmia (disease) An inflammation process occurring in a heart valve. inflammation process in a heart valve heart bodily process A dilated cardiomyopathy that has a genetic origin. genetic dilated cardiomyopathy A cardiomyopathy (2008) that has a genetic origin. genetic cardiomyopathy A disorder made of a detached, traveling intravascular matter (solid, liquid, or gaseous) carried by circulation. It is capable of creating an arterial occlusion at a site distant from its point of origin. embolus A disease characterized by an inflammation process. inflammatory disease A pathological process occurring in the myocardium. myocardium pathological process A pathological process involving or occuring in the aorta. aorta pathological process A disorder always located in the aorta. aorta disorder A pathological process occuring in the endocardium. endocardium pathological process A pathological process of thickening of the endocardium. endocardium thickening A disease affecting the endocardium. endocardium disease A disorder always located in the left heart ventricle. left ventricle disorder A disorder always located in the right heart ventricle. right ventricle disorder A disorder always located in a heart ventricle. heart ventricle disorder An ischemia of the heart. heart ischemia vein pathological process An ischemic heart disease leading to a dilatation and dysfunction of the left ventricle. ischemic cardiomyopathy A disorder located in an anatomical entity. material anatomical entity disorder material anatomical entity pathological process cardiovascular system disorder cardiovascular system pathological process A disease that affects a material anatomical entity. disease of material anatomical entity An aortic valve stenosis leading to a hypertrophy or dilatation of the left ventricle and its dysfunction. valvular cardiomyopathy A heart disease in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality. (adapted from Elliott et al., 2008, European Heart Journal, 29, 270-276) Contemporary (e.g. Elliott et al. 2008) definitions of cardiomyopathy exclude ischemic cardiomyopathy, hypertensive cardiomyopathy and valvular cardiomyopathy. cardiomyopathy (2008 definition) left ventricular myocardium contraction dysfunctional process myocardium contraction dysfunctional process A pathological process occurring in the left heart ventricle. left ventricle pathological process A pathological process occurring in the right heart ventricle. right ventricle pathological process "Inflammatory DCM is defined by the presence of chronic inflammatory cells in association with left ventricular dilatation and reduced ejection fraction". (Elliott et al., 2008) inflammatory dilated cardiomyopathy inflammatory dilated cardiomyopathy A hypertensive heart disease leading to a hypertrophy and dysfunction of the left ventricle. hypertensive cardiomyopathy A heart disease existing at birth, or developping during the first month after birth. congenital heart disease A disease affecting a heart ventricle. heart ventricle disease A disease affecting a heart left ventricle. left ventricle disease A disease affecting a heart right ventricle. right ventricle disease ventricular myocardium contraction dysfunctional process right ventricular myocardium contraction dysfunctional process myocardium of left ventricle stiffening A pathological process occurring in a heart valve. heart valve pathological process A pathological process occurring in an aortic valve. aortic valve pathological process A pathological process occurring in a mitral valve. mitral valve pathological process A pathological process occurring in a tricuspid valve. tricuspid valve pathological process A pathological process occurring in a pulmonary valve. pulmonary valve pathological process A disease affecting the myocardium. myocardium disease A heart disease that has a genetic disorder. genetic heart disease A disease existing at birth, or developping during the first month after birth. congenital disease coronary artery pathological process A pathological process of coronary artery smooth muscle constriction. coronary artery smooth muscle constriction A cardiomyopathy characterized by adipose and fibrosis infiltration in the right ventricular myocardium. It is caused by genetic defects of desmosomes (which are parts of the myocardium) and may result in arrhythmia. A heart conduction disease that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death by ventricular tachyarrhytmia. An atrial fibrillation disease that has a genetic origin. familial atrial fibrillation Disease of the myocardium associated with cardiac dysfunction. (Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies) DOID label "cardiomyopathy" was changed. An endocarditis caused by infection. DOID label 'marantic endocarditis' was changed in CVDO (non-bacterial thrombotic endocarditis is a more common name). marantic endocarditis non-bacterial thrombotic endocarditis DOID label changed to 'left anterior fascicular block (disease)' for symmetry reasons with 'left posterior fascicular block (disease)' left anterior fascicular block (disease) A disease affecting the conducting tissue of the heart. A disease characterized by an inflammation of the endocardium. DOID label 'anomalous atrioventricular excitation' was changed. DOID label changed for homogeneization reasons. Mobitz II second degree atrioventricular block (disease) A disease affecting the heart. A disease caused by the presence of fluid in the pericardial cavity (due to pericardial effusion), affecting negatively the heart's pumping function. In CVDO, cardiac tamponade is defined as *being caused* by a pericardial effusion, rather than as *being* a pericardial effusion. A disease in which an abnormal structure in a mitral valve prevents it to close propertly during systole, occasioning a retrograd blood flow through the valve. A disease characterized by an inflammation of a retinal artery. A thrombosis that occurs in a portal vein. A coronary heart disease with coronary artery smooth muscle constriction. A thrombosis occuring in a coronary artery. "A heart disease with increased ventricular wall thickness or mass in the absence of loading conditions (hypertension, valve disease) sufficient to cause the observed abnormality." (Elliott et al., 2008, European Heart Journal, 29, 270-276) A cor pulmonale that has a chronic disease course during which the right ventricle becomes hypertrophied. A disease affecting the cardiovascular system. A heart disease in which the endocardium thickens by increase in the amount of supporting connective tissue and elastic fibers. It is usually associated with children two years old and younger. Its etiological cause is unknown. A cardiomyopathy characterized by left ventricular dilatation and left ventricular systolic dysfunction in the absence of abnormal loading conditions (hypertension, valve disease) or coronary heart disease sufficient to cause global systolic impairment. (adapted from Elliott et al., 2008, European Heart Journal, 29, 270-276) A dilated cardiomyopathy resulting from alcohol intoxication. A heart conduction disease characterized by inappropriate sinus rates (e.g. sinus bradycardia or sinus pause). A disease in which an abnormal structure in a pulmonary valve prevents it to close propertly during diastole, occasioning a retrograd blood flow through the valve. An embolism due to an embolus made of cholesterol. A disease in which some disorder of the aortic valve leads prevents it from opening properly during left ventricular systole, occasioning disturbance in the anterograd blood flow through the valve. A disease in which some disorder of a mitral valve prevents it from opening properly during left ventricular diastole, occasioning disturbance in the anterograd blood flow through the valve. A disease affecting a blood vessel. Reorganization of the vascular diseases, and writing of Aristotelian definitions, is still ongoing. A disease characterized by an inflammation of the pericardium. A chronic pericarditis due to rheumatic fever. A congenital disease involving the narrowing (stenosis) of aorta, hindering the opening of the aortic valve. Supravalvular aortic stenosis is not classified as an aortic valve stenosis: although the narrowing of the section of the aorta at the exit of the aortic valve implies some improper opening of the aortic valve, the aortic valve is (in general) healthy (there is no disorder nor pathological process inside it). However, this improper opening of the aortic valve is a pathological process that happens inside the heart; therefore, supravalvular aortic stenosis is classified as a heart disease. A brain ischemia that is part of a transient disease course. An ischemia of the brain. A disposition that an aneurysm disorder will lead to pathological processes. DOID label 'aneurysm disease' changed for homogeneization purpose in CVDO. A pathological process of restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism. An ischemic heart disease with narrowing of the coronary arteries. A disease characterized by reduced blood supply to the heart, occasioning pathological processes in the heart. A thrombosis occurring in a carotid artery. An infarction occurring in the brain. A pathological process of disturbance in the blood supply to the brain, causing a loss of brain function. A thrombosis that occurs in a dural venous sinus. A thrombosis that occurs in a transverse sinus. A myocarditis with an acute disease course. A cardiomyopathy (2008) characterized by increased stiffness of the left ventricular myocardium and decreased compliance of the left ventricle (which is restricted from stretching and filling with blood properly), in the absence of dilated cardiomyopathy and hypertrophic cardiomyopathy. A disease in which some disorder of a tricuspid valve prevents it from opening properly during right ventricular diastole, occasioning disturbance in the anterograd blood flow through the valve. A disease affecting a valve of the heart. A disease in which an abnormal structure in a mitral valve prevents it to close propertly during systole, occasioning a retrograd blood flow through the valve. A thrombosis occurring in the brain. A disorder of atheromous plaques in a coronary artery. A bacterial endocarditis characterized by a slow process of infection. A disease characterized by an inflammation of the aorta. A disease affecting the aorta. A disease characterized by the displacement of a degenerated aortic valve leaflet into the left ventricle during diastole. A disease characterized by the displacement of a degenerated tricuspid valve leaflet into the right atrium during systole. A disease in which an abnormal structure in an aortic valve prevents it to close propertly during diastole, occasioning a retrograd blood flow through the valve. A disease affecting the pulmonary valve of the heart. This refers to a narrowing of the section of the left ventricle below the aortic valve; therefore, this was not classified as an aortic valve stenosis in CVDO. An infarction occurring in the myocardium. A disease characterized by the inability of the heart to pump a sufficient amount of blood throughout the body. A disease affecting the mitral valve of the heart. A disease affecting the aortic valve of the heart. A disease in which some disorder of a pulmonary valve prevents it from opening properly during right ventricular systole, occasioning disturbance in the anterograd blood flow through the valve. A disease characterized by an inflammation of the myocardium. A cor pulmonale that has an acute disease course during which the right ventricle becomes dilated. 'Acute pulmonary heart disease' and 'Acute cor pulmonale' (two classes imported from DOID) are considered as equivalent in CVDO. A disease characterized by a dilatation or hypertrophy of the myocardium of right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs, involving a failure of the right side of the heart. Although the 1995 classification of cardiomyopathies did not include cor pulmonale, it should have included it, given the definition of cardiomyopathy it adopted. A pathological process consisting in a pulmonary embolism and an infarction that follows. 'Acute pulmonary heart disease' and 'Acute cor pulmonale' (two classes imported from DOID) are considered as equivalent in CVDO. A disease characterized by an inflammation of a vein. A disease characterized by an inflammation of a blood vessel. A coronary heart disease with an acute disease course. DOID label 'intermediate coronary syndrome' was changed. DOID label 'pulmonary subvalvular stenosis' was changed for homogeneization with 'subvalvular aortic stenosis'. pulmonary subvalvular stenosis An embolism that occurs in a pulmonary artery. A congestive heart failure with impaired ejection fraction. A congestive heart failure with preserved ejection fraction. A disease characterized by the displacement of a degenerated mitral valve leaflet into the left atrium during systole. A disease characterized by the displacement of a degenerated heart valve leaflet during systole. This class was relocated as a son of BFO 'Material entity', and BFO 2.0 'located in at all times' relations were added between relevant FMA classes; they should ultimately be replaced by a genuine version of FMA using BFO 2.0 relations. In order to obtain the taxonomy of diseases / disorders / pathological process in CVDO, it is necessary to use the reasoner first and to look at the inferred class hierarchy. intracranial aneurysm disease ruptured thoracoabdominal aortic aneurysm disease A chronic pulmonary heart disease caused by a kyphoscoliosis. A restrictive cardiomyopathy which results in fibrous lesions of right and left ventricle. It occurs typically in tropical and subtropical Africa. thoracic aortic aneurysm disease splenic artery aneurysm disease A congestive heart failure caused by a rheumatic fever. An ischemia occurring in the spinal cord. coronary aneurysm disease subclavian artery aneurysm disease A thrombosis that occurs in a cavernous sinus. aortic aneurysm disease An aortic valve insufficiency due to rheumatic fever. ruptured aortic aneurysm disease dissecting aortic aneurysm disease ruptured abdominal aortic aneurysm disease abdominal aortic aneurysm disease ruptured thoracic aortic aneurysm disease A myocarditis caused by rheumatic fever. A dilated cardiomyopathy resulting from a pregnancy. It presents typically between the last month of pregnancy and up to six months postpartum. PlainLiteral label