Prefix(:=) Prefix(dce:=) Prefix(owl:=) Prefix(rdf:=) Prefix(xml:=) Prefix(xsd:=) Prefix(rdfs:=) Prefix(dcterms:=) Ontology( Import() Import() Import() Import() Import() Import() Import() Import() Import() Import() Import() Import() Annotation(dce:creator "Eric Joseph") Annotation(dce:creator "Josh Hanna") Annotation(dce:creator "Mathias Brochhausen") Annotation(dce:creator "William Hogan") Annotation(dce:description "We built this ontology primarily to support comparative effectiveness researchers studying claims data. They need to be able to query U.S. National Drug Codes (NDCs) by ingredient, mechanism of action (beta-adrenergic blockade), physiological effect (diuresis), and therapeutic intent (anti-hypertensive).") Annotation(dce:title "The Drug Ontology") Annotation(dcterms:license ) Annotation(rdfs:comment "An ontology of drugs.") Annotation(rdfs:comment "DrOn contains content developed by the National Library of Medicine in RxNorm. In creating DrOn, we have used RxNorm content only with SAB = RXNORM.") Annotation(rdfs:comment "This version of DrOn is current through the June, 2020 version of RxNorm.") Annotation(rdfs:comment "When citing DrOn, use the permanent URL of the ontology: http://purl.obolibrary.org/obo/dron.owl. When referencing a specific component of the DrOn, such as a class, object property, annotation property, or individual, use the Uniform Resource Identifier (URI) of that component."@en) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) 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Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(DataProperty()) Declaration(NamedIndividual()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty(dce:creator)) Declaration(AnnotationProperty(dce:source)) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) ############################ # Annotation Properties ############################ # Annotation Property: (has_alternative_id) AnnotationAssertion(rdfs:label "has_alternative_id") # Annotation Property: (database_cross_reference) AnnotationAssertion(rdfs:label "database_cross_reference") # Annotation Property: (has_exact_synonym) AnnotationAssertion(rdfs:label "has_exact_synonym") # Annotation Property: (has narrow synonym) AnnotationAssertion(rdfs:label "has_narrow_synonym") # Annotation Property: (has_obo_namespace) AnnotationAssertion(rdfs:label "has_obo_namespace") # Annotation Property: (has_related_synonym) AnnotationAssertion(rdfs:label "has_related_synonym") # Annotation Property: (in_subset) AnnotationAssertion(rdfs:label "in_subset") # Annotation Property: (shorthand) AnnotationAssertion(rdfs:label "shorthand") # Annotation Property: rdfs:label (label) AnnotationAssertion(rdfs:label rdfs:label "label") ############################ # Object Properties ############################ # Object Property: (realized in) AnnotationAssertion(rdfs:isDefinedBy ) # Object Property: (realizes) AnnotationAssertion(rdfs:isDefinedBy ) # Object Property: () AnnotationAssertion(rdfs:isDefinedBy ) # Object Property: () AnnotationAssertion(rdfs:isDefinedBy ) # Object Property: () AnnotationAssertion(rdfs:isDefinedBy ) # Object Property: (has value specification) AnnotationAssertion( ) # Object Property: (characteristic of) AnnotationAssertion( ) # Object Property: (has characteristic) AnnotationAssertion( ) # Object Property: (has_part) AnnotationAssertion( "http://purl.org/obo/owl/relationship") AnnotationAssertion( "OBO_REL:0000003") AnnotationAssertion( "relationship") AnnotationAssertion(rdfs:label "has_part"@en) SubObjectPropertyOf( owl:topObjectProperty) # Object Property: (has_proper_part) AnnotationAssertion( "http://purl.org/obo/owl/relationship") AnnotationAssertion( "OBO_REL:0000007") AnnotationAssertion( "relationship") AnnotationAssertion(rdfs:label "has_proper_part"@en) SubObjectPropertyOf( owl:topObjectProperty) ############################ # Data Properties ############################ # Data Property: (has specified numeric value) AnnotationAssertion( ) ############################ # Classes ############################ # Class: (chemical resistance to infection) SubClassOf( ) # Class: (zafirlukast) SubClassOf( ObjectSomeValuesFrom( )) # Class: (zileuton) SubClassOf( ObjectSomeValuesFrom( )) # Class: (nordazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (tetrazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (ketazolam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (metaclazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: ((-)-ephedrine) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cortisone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cortisol) SubClassOf( ObjectSomeValuesFrom( )) # Class: (alprazolam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (caffeine) SubClassOf( ObjectSomeValuesFrom( )) # Class: (theophylline) SubClassOf( ObjectSomeValuesFrom( )) # Class: (beclomethasone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (bendroflumethiazide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (betamethasone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Bromazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Brotizolam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Ciclesonide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (clobazam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Clotiazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cloxazolam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cyclothiazide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (flunitrazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Medazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (budesonide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (chlordiazepoxide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (subatomic particle) SubClassOf( ) # Class: (chlorothiazide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (chlorthalidone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (clonazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (dexamethasone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (dyphylline) SubClassOf( ObjectSomeValuesFrom( )) # Class: (estazolam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (etacrynic acid) SubClassOf( ObjectSomeValuesFrom( )) # Class: (diazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (montelukast) SubClassOf( ObjectSomeValuesFrom( )) # Class: (role) SubClassOf( ) # Class: (flumazenil) SubClassOf( ObjectSomeValuesFrom( )) # Class: (flunisolide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (flurazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (fluticasone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (formoterol) SubClassOf( ObjectSomeValuesFrom( )) # Class: (lormetazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Halazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (hydrochlorothiazide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (hydroflumethiazide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (indapamide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (ipratropium) SubClassOf( ObjectSomeValuesFrom( )) # Class: (clorazepic acid anion) SubClassOf( ObjectSomeValuesFrom( )) # Class: (metolazone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (metaproterenol) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Methyclothiazide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (6alpha-methylprednisolone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (midazolam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (mometasone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (meclofenamic acid(1-)) SubClassOf( ObjectSomeValuesFrom( )) # Class: (oxazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Polythiazide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Prazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (prednisone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Quazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (quinethazone) SubClassOf( ObjectSomeValuesFrom( )) # Class: ((R)-salbutamol) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Temazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (terbutaline) SubClassOf( ObjectSomeValuesFrom( )) # Class: (triamcinolone) SubClassOf( ObjectSomeValuesFrom( )) # Class: (triazolam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (trichlormethiazide) SubClassOf( ObjectSomeValuesFrom( )) # Class: (clinical drug role) AnnotationAssertion( "the role of a material entity to prevent, diagnose, treat, or study disease and/or its effects"@en) AnnotationAssertion( "William Hogan") AnnotationAssertion(dce:creator "William Hogan") AnnotationAssertion(rdfs:label "clinical drug role"@en) SubClassOf( ) # Class: (portion of pure substance) AnnotationAssertion( "an object all of whose parts that are atoms or molecules are of the same type (as determined by a unique structure)"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "portion of pure substance"@en) SubClassOf( ) # Class: (portion of element) AnnotationAssertion( "a portion of pure substance all of whose atomic parts are of the same type (as determined by a unique structure)"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:comment "the \"unique structure\" clause differentiates a portion of diatomic oxygen from a portion of ozone, graphite from diamond, etc."@en) AnnotationAssertion(rdfs:label "portion of element"@en) SubClassOf( ) # Class: (portion of compound) AnnotationAssertion( "a portion of pure substance whose molecular parts are of the same type (as determined by a unique structure), but whose atomic parts are of different types (as determined by a unique structure)"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:comment "The latter clause in the definition excludes diatomic molecules of chlorine, oxygen, nitrogen, etc."@en) AnnotationAssertion(rdfs:label "portion of compound"@en) SubClassOf( ) # Class: (drug product) AnnotationAssertion( "a material entity (1) containing at least one scattered molecular aggregate as part that is the bearer of an active ingredient role and (2) that is itself the bearer of a clinical drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug product"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (portion of mixture) AnnotationAssertion( "a material entity that contains two or more scattered object aggregates as its only parts, where the grains of each object aggregate are of different types and evenly distributed throughout, such that any two parts of the entity, each of which is spatially contiguous and of the same size, contain nearly equal numbers of grains of the aggregates"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:comment "Examples: saline solution, a suspension of dust particles in air, milk."@en) AnnotationAssertion(rdfs:comment "Typically, the grains of the object aggregates are molecules (as in a solution of salt in water), but a mate- rial entity made of gravel mixed in a heap of soil also meets the definition, where the grains are individual rocks (gravel) and particles of soil."@en) AnnotationAssertion(rdfs:label "portion of mixture"@en) SubClassOf( ) # Class: (portion of solution) AnnotationAssertion( "a portion of mixture of two or more portions of pure substances whereby one or more of its pure substance parts called solute(s) is (are) dispersed evenly in another pure substance part called the solvent, whereby (1) the grains of the solvent and solute(s) are of size ≤10^-9m, and (2) the solvent typically has a much greater mass and volume than the solute(s)"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:comment "The phase (solid, liquid, gas) of the solution is usually the phase of the solvent."@en) AnnotationAssertion(rdfs:label "portion of solution"@en) SubClassOf( ) # Class: (portion of suspension) AnnotationAssertion( "a portion of mixture whereby the grains of at least one object aggregate are ≥1 μm in size and the grains of at least one other object aggregate are ≤10-9m in size"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:comment "The two aggregates can be separated by gravitational settling of the grains ≥1 μm. Example: portion of blood (red blood cells and other large grains will settle out in a static portion of blood)."@en) AnnotationAssertion(rdfs:label "portion of suspension"@en) SubClassOf( ) # Class: (portion of colloid) AnnotationAssertion( "a portion of mixture whereby the grains of at least one object aggregate are >10-9m and <1 μm in size (the dispersed material) and the grains of at least one other object aggregate are <10-9m in size (continuous medium)"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:comment "The aggregates cannot be separated by gravitational settling. Note that in certain cases such as aerosols and foams, the grains are relatively large contiguous por- tions of liquid or gas dispersed in a medium, even though the molecules/atoms that make up the grains are small."@en) AnnotationAssertion(rdfs:label "portion of colloid"@en) SubClassOf( ) # Class: (portion of emulsion) AnnotationAssertion( "a portion of colloid where both the dispersed material and the continuous medium are liquids"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "portion of emulsion"@en) SubClassOf( ) # Class: (portion of cream) AnnotationAssertion( "a portion of emulsion of oil and water in nearly equal proportions with high viscosity"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "portion of cream"@en) SubClassOf( ) # Class: (portion of lotion) AnnotationAssertion( "a portion of emulsion of oil and water in nearly equal proportions with low viscosity"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "portion of lotion"@en) SubClassOf( ) # Class: (portion of ointment) AnnotationAssertion( "a portion of emulsion of oil and water where the proportion of oil is significantly greater than proportion of water, typically 80% oil and 20% water"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "portion of ointment"@en) SubClassOf( ) # Class: (portion of gel) AnnotationAssertion( "a portion of colloid whereby a liquid is dispersed in a solid that is either gelatin, jelly, or agar"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "portion of gel"@en) SubClassOf( ) # Class: (drug gel) AnnotationAssertion( "a portion of gel that is the bearer of a clinical drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug gel"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (drug emulsion) AnnotationAssertion( "a portion of emulsion that is the bearer of a clinical drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug emulsion"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (drug cream) AnnotationAssertion( "a portion of cream that is the bearer of a clinical drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug cream"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (drug lotion) AnnotationAssertion( "a portion of lotion that is the bearer of a drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug lotion"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (drug ointment) AnnotationAssertion( "a portion of lotion that is the bearer of a clinical drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug ointment"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (drug solution) AnnotationAssertion( "a portion of solution that is the bearer of a clinical drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (drug suspension) AnnotationAssertion( "a portion of suspension that is the bearer of a clinical drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (drug tablet) AnnotationAssertion( "a solid object typically of discoid, spheroid, or elliptic-cylindrical shape or approximations thereof, that bears a clinical drug role."@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug tablet"@en) SubClassOf( ) SubClassOf( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) # Class: (portion of foam) AnnotationAssertion( "a portion of colloid whereby a gas is dispersed in a liquid"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "portion of foam"@en) SubClassOf( ) # Class: (drug foam) AnnotationAssertion( "a portion of foam that is the bearer of a clinical drug role"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug foam"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (FDA approved drug role) AnnotationAssertion( "a drug role conferred by the United States Food and Drug Administration that permits the production, marketing, sale, prescribing, and consump- tion of its bearer in the United States"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "FDA approved drug role"@en) SubClassOf( ) # Class: (drug capsule) AnnotationAssertion( "an object that is the bearer of a drug role and is comprised of a solid shell of elliptical-cylindrical shape and another object contained in the shell that has a scattered molecular aggregate as a proper part"@en) AnnotationAssertion( "William Hogan"@en) AnnotationAssertion(dce:creator "William Hogan"@en) AnnotationAssertion(rdfs:label "drug capsule"@en) SubClassOf( ) SubClassOf( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) # Class: (packaged drug product) AnnotationAssertion(rdfs:label "packaged drug product"@en) SubClassOf( ) # Class: (active ingredient) AnnotationAssertion( "active ingredient role"@en) AnnotationAssertion( "a role of a scattered molecular aggregate that is part of a drug product that is realized by (1) administration of the drug to an organism followed by (2) some change in the structure or functioning of some part of the organism"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion(rdfs:label "active ingredient"@en) SubClassOf( ) SubClassOf( ObjectAllValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )))))) # Class: (excipient) AnnotationAssertion( "excipient role"@en) AnnotationAssertion( "a role of a scattered molecular aggregate in aiding the manufacture, prolonging the shelf life, or ensuring proper administration of a drug product"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion(rdfs:comment "not all excipients aid in delivery of the drug, although it is their most common role. examples include preservatives and sorbents."@en) AnnotationAssertion(rdfs:comment "some excipients are used in manufacture of a drug product and do not end up being part of the drug product at the end, for example, water in the manufacture of lyophilized products and inert gasses in the headspace of containers (http://www.ipapharma.org/epharmatimes/Mar2013/#65). the net result is that the aggregate bearing the excipient role need not be part of the drug product."@en) AnnotationAssertion(rdfs:label "excipient"@en) SubClassOf( ) # Class: (role of scattered molecular aggregate) AnnotationAssertion( "role of a scattered molecular aggregate"@en) AnnotationAssertion( "a role borne by a scattered molecular aggregate and realized by its grains participating in one or more processes"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion(rdfs:label "role of scattered molecular aggregate"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (drug administration) AnnotationAssertion( "administration of a drug product to an organism"@en) AnnotationAssertion( "a treatment that has as participants an extended organism and a drug product and that results in part of the drug product being located in the extended organism"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion(rdfs:label "drug administration"@en) SubClassOf( ) SubClassOf( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (drug product therapeutic function) AnnotationAssertion( "therapeutic function of a drug product"@en) AnnotationAssertion( "a function inhering in a drug product that when realized, is realized by a process that either (1) negatively regulates symptom processes, processes leading to symptoms, and/or the realization of a disease, (2) has specified output some entity useful in the diagnosis of disease, or (3) negatively regulates or blocks etiological processes."@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "indication of drug product"@en) AnnotationAssertion(rdfs:label "drug product therapeutic function"@en) SubClassOf( ) SubClassOf( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (anti-malarial function of a drug product) AnnotationAssertion( "anti-malarial function of a drug product"@en) AnnotationAssertion( "a therapeutic function of a drug product that is realized by administration of the drug product resulting in creation of a material basis of a resistance to malaria infection disposition"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "anti-malarial"@en) AnnotationAssertion( "anti-malarial indication"@en) AnnotationAssertion(rdfs:label "anti-malarial function"@en) SubClassOf( ) # Class: (anti-hypertensive function of a drug product) AnnotationAssertion( "anti-hypertensive function of a drug product"@en) AnnotationAssertion( "a therapeutic function of a drug product that is realized by administration of the drug product resulting in a decrease of systemic arterial pressure"@en) AnnotationAssertion( "Tim Modzelewski") AnnotationAssertion( "anti-hypertensive"@en) AnnotationAssertion(rdfs:label "anti-hypertensive function"@en) SubClassOf( ) # Class: (analgesic function of a drug product) AnnotationAssertion( "analgesic function of a drug product"@en) AnnotationAssertion( "a therapeutic function of a drug product that is realized by administration of the drug product resulting in blocked realization of a disposition to pain"@en) AnnotationAssertion( "Amanda Hicks"@en) AnnotationAssertion( "Baxter Bramblett"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "Matthew Diller"@en) AnnotationAssertion( "Mirlea Vasconcelos"@en) AnnotationAssertion( "Rodel Enderez"@en) AnnotationAssertion( "Samira Amirova"@en) AnnotationAssertion( "Tim Modzelewski"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "analgesic"@en) AnnotationAssertion(rdfs:label "analgesic function"@en) SubClassOf( ) # Class: (function-inhibiting mu receptor binding disposition) AnnotationAssertion( "function-inhibiting mu opioid receptor binding disposition"@en) AnnotationAssertion( "a disposition of a molecule to bind an instance of a mu opioid receptor in a manner that inhibits the realization of a biological function of the receptor instance​"@en) AnnotationAssertion( "Amanda Hicks"@en) AnnotationAssertion( "Baxter Bramblett"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "Matthew Diller"@en) AnnotationAssertion( "Mirela Vasconcelos"@en) AnnotationAssertion( "Rodel Enderez"@en) AnnotationAssertion( "Samria Amirova"@en) AnnotationAssertion( "Tim Modzelewski"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "mu antagonist"@en) AnnotationAssertion( "mu inhibitor"@en) AnnotationAssertion(rdfs:label "function-inhibiting mu receptor binding disposition"@en) SubClassOf( ) # Class: (function-activating mu receptor binding disposition) AnnotationAssertion( "function-activating mu opioid receptor binding disposition"@en) AnnotationAssertion( "a disposition of a molecule to bind an instance of a mu opioid receptor in a manner that activates the realization of a biological function of the receptor instance​"@en) AnnotationAssertion( "Amanda Hicks"@en) AnnotationAssertion( "Baxter Bramblett"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "Matthew Diller"@en) AnnotationAssertion( "Mirela Vasconcelos"@en) AnnotationAssertion( "Rodel Enderez"@en) AnnotationAssertion( "Samria Amirova"@en) AnnotationAssertion( "Tim Modzelewski"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "mu agonist"@en) AnnotationAssertion(rdfs:label "function-activating mu receptor binding disposition"@en) SubClassOf( ) # Class: (function-inhibiting delta receptor binding disposition) AnnotationAssertion( "function-inhibiting delta opioid receptor binding disposition"@en) AnnotationAssertion( "a disposition of a molecule to bind an instance of a delta opioid receptor in a manner that inhibits the realization of a biological function of the receptor instance​"@en) AnnotationAssertion( "Amanda Hicks"@en) AnnotationAssertion( "Baxter Bramblett"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "Matthew Diller"@en) AnnotationAssertion( "Mirela Vasconcelos"@en) AnnotationAssertion( "Rodel Enderez"@en) AnnotationAssertion( "Samria Amirova"@en) AnnotationAssertion( "Tim Modzelewski"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "delta antagonist"@en) AnnotationAssertion( "delta inhibitor"@en) AnnotationAssertion(rdfs:label "function-inhibiting delta receptor binding disposition"@en) SubClassOf( ) # Class: (function-activating delta receptor binding disposition) AnnotationAssertion( "function-activating delta opioid receptor binding disposition"@en) AnnotationAssertion( "a disposition of a molecule to bind an instance of a delta opioid receptor in a manner that activates the realization of a biological function of the receptor instance​"@en) AnnotationAssertion( "Amanda Hicks"@en) AnnotationAssertion( "Baxter Bramblett"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "Matthew Diller"@en) AnnotationAssertion( "Mirela Vasconcelos"@en) AnnotationAssertion( "Rodel Enderez"@en) AnnotationAssertion( "Samria Amirova"@en) AnnotationAssertion( "Tim Modzelewski"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "delta agonist"@en) AnnotationAssertion(rdfs:label "function-activating delta receptor binding disposition"@en) SubClassOf( ) # Class: (function-inhibiting kappa receptor binding disposition) AnnotationAssertion( "function-inhibiting kappa opioid receptor binding disposition"@en) AnnotationAssertion( "a disposition of a molecule to bind an instance of a kappa opioid receptor in a manner that inhibits the realization of a biological function of the receptor instance​"@en) AnnotationAssertion( "Amanda Hicks"@en) AnnotationAssertion( "Baxter Bramblett"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "Matthew Diller"@en) AnnotationAssertion( "Mirela Vasconcelos"@en) AnnotationAssertion( "Rodel Enderez"@en) AnnotationAssertion( "Samria Amirova"@en) AnnotationAssertion( "Tim Modzelewski"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "kappa antagonist"@en) AnnotationAssertion( "kappa inhibitor"@en) AnnotationAssertion(rdfs:label "function-inhibiting kappa receptor binding disposition"@en) SubClassOf( ) # Class: (function-activating kappa receptor binding disposition) AnnotationAssertion( "function-activating kappa opioid receptor binding disposition"@en) AnnotationAssertion( "a disposition of a molecule to bind an instance of a kappa opioid receptor in a manner that activates the realization of a biological function of the receptor instance​"@en) AnnotationAssertion( "Amanda Hicks"@en) AnnotationAssertion( "Baxter Bramblett"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "Matthew Diller"@en) AnnotationAssertion( "Mirela Vasconcelos"@en) AnnotationAssertion( "Rodel Enderez"@en) AnnotationAssertion( "Samria Amirova"@en) AnnotationAssertion( "Tim Modzelewski"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "kappa agonist"@en) AnnotationAssertion(rdfs:label "function-activating kappa receptor binding disposition"@en) SubClassOf( ) # Class: (administration coating excipient) AnnotationAssertion( "administration coating excipient role"@en) AnnotationAssertion( "a coating excipient role that is realized by facilitating a process of drug administration"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "An administration coating is one that somehow improves administration of the drug, by for example making insertion or consumption of the drug easier or masking undesirable flavors."@en) AnnotationAssertion(rdfs:label "administration coating excipient"@en) SubClassOf( ) # Class: (flavor coating excipient) AnnotationAssertion( "flavor coating excipient role"@en) AnnotationAssertion( "an administration coating excipient role that is realized by a drug manufacturing process that results in the drug product bearing a particular flavor quality"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Flavored coatings make it more palatable to consume a drug product by improving its taste, often by masking the unpleasant taste of the active ingredients."@en) AnnotationAssertion(rdfs:label "flavor coating excipient"@en) SubClassOf( ) # Class: (lubricant coating excipient) AnnotationAssertion( "lubricant coating excipient role"@en) AnnotationAssertion( "an administration coating excipient role that is realized by decreased friction between the drug product and some part of an organism during drug administration"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "A lubricant coating makes it easier to consume or insert a drug product by decreasing the friction or adhesion between the drug preparation and some body part such as the throat or esophagus."@en) AnnotationAssertion(rdfs:label "lubricant coating excipient"@en) SubClassOf( ) # Class: (color excipient) AnnotationAssertion( "color excipient role"@en) AnnotationAssertion( "an excipient role that is realized by a process of drug manufacturing that results in a particular, desired color quality inhering in the drug product"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Colored excipients are added to a drug preparation to make various kinds of drugs more easily identifiable by sight to decrease the possibility of using the wrong dosage or wrong drug product altogether."@en) AnnotationAssertion(rdfs:label "color excipient"@en) SubClassOf( ) # Class: (flavor excipient) AnnotationAssertion( "flavor excipient role"@en) AnnotationAssertion( "an excipient role that is realized by a process of drug manufacturing that results in the drug product bearing a particular flavor quality"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Like a flavored coating, a flavored excipient is added to the drug preparation to make it more palatable. This is especially important for drug products targeted towards children to make administration easier."@en) AnnotationAssertion(rdfs:label "flavor excipient"@en) SubClassOf( ) # Class: (disintegrant excipient) AnnotationAssertion( "disintegrant excipient role"@en) AnnotationAssertion( "an excipient role that is realized by a process of drug administration followed by the drug product breaking apart"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "A disintegrant is added to a drug preparation to cause it to break apart whenever it is introduced to moisture. A disintegrant can improve administration (such as oral medications that dissolve in the mouth) or improve uptake of active ingredients for example, in the intestine."@en) AnnotationAssertion(rdfs:label "disintegrant excipient"@en) SubClassOf( ) # Class: (preservative excipient) AnnotationAssertion( "preservative excipient role"@en) AnnotationAssertion( "an excipient role that is realized by increasing the duration of time that a drug product is effective or by inhibiting contamination of the drug product with a microorganism"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Preservatives are added to a drug preparation to increase the lifetime of the drug preparation. Examples include antioxidants such as ascorbic acid that prevent oxidation-reduction reactions that change active ingredients into inactive compounds and methyl paraben which is an antimicrobial preservative."@en) AnnotationAssertion(rdfs:label "preservative excipient"@en) SubClassOf( ) # Class: (sorbent excipient) AnnotationAssertion( "sorbent excipient role"@en) AnnotationAssertion( "an excipient role that is realized by its bearer binding with water in the environment to prevent water binding with other ingredients in the drug product"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Sorbents are added to protect the drug preparation from destruction or disintegration by water. A common example is a desiccant, which is a sorbent that prevents absorption of water into the drug product."@en) AnnotationAssertion(rdfs:label "sorbent excipient"@en) SubClassOf( ) # Class: (vehicle excipient) AnnotationAssertion( "vehicle excipient role"@en) AnnotationAssertion( "an excipient role that is realized by a completed process of the active ingredient reaching its intended destination during drug administration"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Generally, vehicles are the media in which the active ingredient is dispersed to facilitate the active ingredient reaching its intended target tissue. For example, active ingredients that exist in solid form such as a powder cannot be directly injected intravenously without causing damage to veins or becoming emboli that cause damage to the lungs. Thus they are dissolved in solution for safe and proper administration. Other examples of vehicles include creams, ointments, lotions, gels, and solvents for ophthalmic, otic, and oral solutions."@en) AnnotationAssertion(rdfs:label "vehicle excipient"@en) SubClassOf( ) # Class: (lubricant excipient) AnnotationAssertion( "lubricant excipient role"@en) AnnotationAssertion( "an excipient role that is realized by a process of drug administration or a process of drug manufacturing and results in either 1) decreased adhesion between drug ingredients and manufacturing equipment or between drug ingredients and some part of an organism; 2) decreased friction between drug ingredients and manufacturing equipment or between drug ingredients and some part of an organism; or 3) decreased cohesion among particles within the drug product"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Lubricant excipients are added to drug products to prevent ingredients from sticking to themselves (cohesion) and to other things with which they come into contact (adhesion). Common lubricants are minerals like magnesium stearate."@en) AnnotationAssertion(rdfs:label "lubricant excipient"@en) SubClassOf( ) # Class: (glidant excipient) AnnotationAssertion( "glidant excipient role"@en) AnnotationAssertion( "a lubricant excipient role that is realized by a process of drug administration or a process of drug manufacturing and results in decreased cohesion or friction among particles within a drug product"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "A glidant is added to a drug product to reduce cohesion and interparticle friction. Common glidants are talc and magnesium carbonate."@en) AnnotationAssertion(rdfs:label "glidant excipient"@en) SubClassOf( ) # Class: (anti-adherent excipient) AnnotationAssertion( "anti-adherent excipient role"@en) AnnotationAssertion( "a lubricant excipient role that is realized by a process of drug administration or a process of drug manufacturing and results in decreased adhesion between drug ingredients and manufacturing equipment or between drug ingredients and some part of an organism"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Anti-adherents are added to drug products to decrease the tendency of drug molecules to adhere to manufacturing equipment or some body part such as the throat or esophagus during swallowing."@en) AnnotationAssertion(rdfs:label "anti-adherent excipient"@en) SubClassOf( ) # Class: (anti-friction excipient) AnnotationAssertion( "anti-friction excipient role"@en) AnnotationAssertion( "a lubricant excipient that is realized by a process of drug administration or a process of drug manufacturing and results in decreased friction between drug ingredients and manufacturing equipment or between drug ingredients and some part of an organism"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Anti-friction excipients are added to decrease either internal friction (i.e., friction between ingredient parti- cles) or friction between the drug ingredients or product and some other object, such as manufacturing equip- ment or some body part."@en) AnnotationAssertion(rdfs:label "anti-friction excipient"@en) SubClassOf( ) # Class: (binding excipient) AnnotationAssertion( "binding excipient role"@en) AnnotationAssertion( "an excipient role that is realized by a process of drug manufacturing and results in increased volume or cohesion of the drug product"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Binding excipients are added to drug preparations to 1) bind active ingredients together, and 2) increase the volume of the preparation (which is especially important for formulations with otherwise small volumes). Common binding agents are saccharides (like sucrose) or synthetic compounds like polyethylene glycol."@en) AnnotationAssertion(rdfs:label "binding excipient"@en) SubClassOf( ) # Class: (coating excipient) AnnotationAssertion( "coating excipient role"@en) AnnotationAssertion( "an excipient role borne by an aggregate of molecules on the surface of a solid drug product that is realized by a process of delaying interaction between entities outside the drug product and the other ingredients in the drug product"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "Coatings are extremely common excipients, added to protect the drug preparation from destruction or contamination, to ease administration by making it easier to consume, or to improve flavor."@en) AnnotationAssertion(rdfs:label "coating excipient"@en) SubClassOf( ) # Class: (protective coating excipient) AnnotationAssertion( "protective coating excipient role"@en) AnnotationAssertion( "a coating excipient role that is realized by delaying denaturation, disintegration, or some other method of destruction of a drug product including its active ingredients"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "A protective coating acts against destruction or contamination of a drug preparation by keeping the other drug ingredients, especially active ingredients, away from potentially reactive substances like oxygen, water, and various forms of electromagnetic radiation (e.g., light)."@en) AnnotationAssertion(rdfs:label "protective coating excipient"@en) SubClassOf( ) # Class: (enteric coating excipient) AnnotationAssertion( "enteric coating excipient role"@en) AnnotationAssertion( "a protective coating excipient role that is realized by a process of delaying release of one or more active ingredients from the drug product until some targeted time or location, typically the small or large intestine, within an organism"@en) AnnotationAssertion( "Jiang Bian"@en) AnnotationAssertion( "Josh Hanna"@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion( "enteric coating"@en) AnnotationAssertion( "doi: 10.1186/s13326-016-0048-2") AnnotationAssertion(rdfs:comment "An enteric coating also protects the drug preparation from destruction or contamination, but also is designed to disintegrate on a controlled timeline or in a particular place. For instance, some enteric coatings are designed to withstand the relatively low PH of the stomach, but break down in the relatively high PH of the large intestine, allowing an ingredient that would otherwise be destroyed by or absorbed by the stomach to be absorbed in the intestine."@en) AnnotationAssertion(rdfs:label "enteric coating excipient"@en) SubClassOf( ) # Class: () AnnotationAssertion( "function-inhibiting sodium-chloride cotransporter binding disposition"@en) SubClassOf( ) # Class: (function-inhibiting glucocorticoid steroid receptor binding disposition) AnnotationAssertion( "A disposition to bind to a glucocorticoid steroid receptor in such a way as to prevent the realization of the function of the receptor."@en) AnnotationAssertion( "ciara lusnia"@en) AnnotationAssertion(rdfs:comment "This is the mechanism of action for all common corticosteroids such as prednisone, hydrocortisone, etc."@en) AnnotationAssertion(rdfs:label "function-inhibiting glucocorticoid steroid receptor binding disposition"@en) SubClassOf( ) # Class: (function-activating beta2-adrenergic receptor binding disposition) AnnotationAssertion( "A disposition to bind to a beta2-adrenergic receptor in such a way as to activate the realization of the function of the receptor.") AnnotationAssertion( "ciara lusnia") AnnotationAssertion(rdfs:comment "This is a mechanism of action for many bronchodilator drugs.") AnnotationAssertion(rdfs:label "function-activating beta2-adrenergic receptor binding disposition"@en) SubClassOf( ) # Class: (function-inhibiting 5-lipoxygenase binding disposition) AnnotationAssertion( "A disposition to bind to a 5-lipoxygenase enzyme in such a way to inhibit the realization of the function of the enzyme."@en) AnnotationAssertion( "ciara lusnia"@en) AnnotationAssertion(rdfs:comment "This is a mechanism of action for many leukotriene modifier drugs."@en) AnnotationAssertion(rdfs:label "function-inhibiting 5-lipoxygenase binding disposition"@en) SubClassOf( ) # Class: (non-activating competitive cysteinyl-leukotriene type 1 receptor binding disposition) AnnotationAssertion( "A disposition to bind to a cysteinyl-leukotriene type 1 receptor in such a way to compete with the realization of the function of the receptor.") AnnotationAssertion( "ciara lusnia") AnnotationAssertion(rdfs:comment "This is a mechanism of action for many leukotriene modifiers.") AnnotationAssertion(rdfs:label "non-activating competitive cysteinyl-leukotriene type 1 receptor binding disposition"@en) SubClassOf( ) # Class: (function-activating alpha1A-adrenergic receptor binding disposition) AnnotationAssertion( "A disposition to bind to an alpha1A-adrenergic receptor in such a way to activate the realization of the function of the receptor.") AnnotationAssertion( "ciara lusnia") AnnotationAssertion(rdfs:comment "This is a mechanism of action for many sympathomimetic amines.") AnnotationAssertion(rdfs:label "function-activating alpha1A-adrenergic receptor binding disposition"@en) SubClassOf( ) # Class: (non-activating competitive cysteinyl-leukotriene type 1 receptor binding disposition) AnnotationAssertion(rdfs:label "non-activating competitive cysteinyl-leukotriene type 1 receptor binding disposition"@en) SubClassOf( ) # Class: (non-activating competitive muscarinic cholinergic receptors binding disposition) AnnotationAssertion( "A disposition to bind to a muscarinic cholinergic receptor in such a way to compete with the realization of the function of the receptor.") AnnotationAssertion( "ciara lusnia") AnnotationAssertion(rdfs:comment "This is a mechanism of action for many anticholinergic bronchodilators.") AnnotationAssertion(rdfs:label "non-activating competitive muscarinic cholinergic receptors binding disposition"@en) SubClassOf( ) # Class: (function-inhibiting corticosteroid binding disposition) AnnotationAssertion( "A disposition to bind to a corticosteroid receptor in such a way as to prevent the realization of the function of the receptor.") AnnotationAssertion( "ciara lusnia") AnnotationAssertion(rdfs:comment "This is a mechanism of action for many corticosteroids.") AnnotationAssertion(rdfs:label "function-inhibiting corticosteroid binding disposition"@en) SubClassOf( ) # Class: (non-activating competitive phosphodiesterase binding disposition) AnnotationAssertion( "A disposition to bind to a phosphodiesterase receptor in such a way as to compete with the realization of the function of the enzyme.") AnnotationAssertion( "ciara lusnia") AnnotationAssertion(rdfs:comment "This is a mechanism of action for many methylxanthines.") AnnotationAssertion(rdfs:label "non-activating competitive phosphodiesterase binding disposition"@en) SubClassOf( ) # Class: (function-inhibiting interleukin-5 binding disposition) AnnotationAssertion( "A disposition to bind to a interleukin-5 receptor in such a way as to prevent the realization of the function of the receptor.") AnnotationAssertion( "ciara lusnia") AnnotationAssertion(rdfs:comment "This is a mechanism of action for many mepolizumab systemics.") AnnotationAssertion(rdfs:label "function-inhibiting interleukin-5 binding disposition"@en) SubClassOf( ) # Class: (non-activating competitive type III and type IV phosphodiesterase binding disposition) AnnotationAssertion( "A disposition to bind to a type III and type IV phosphodiesterase receptor in such a way as to compete with the realization of the function of the receptor."@en) AnnotationAssertion( "ciara lusnia"@en) AnnotationAssertion(rdfs:comment "This is a mechanism of action for many theophylline systemics."@en) AnnotationAssertion(rdfs:label "non-activating competitive type III and type IV phosphodiesterase binding disposition"@en) SubClassOf( ) # Class: (non-activating competitive adenosine A1 binding disposition) AnnotationAssertion( "A disposition to bind to an adenosine A1 receptor in such a way as to compete with the realization of the function of the receptor."@en) AnnotationAssertion( "ciara lusnia"@en) AnnotationAssertion(rdfs:comment "This is a mechanism of action for many CNS stimulants."@en) AnnotationAssertion(rdfs:label "non-activating competitive adenosine A1 binding disposition"@en) SubClassOf( ) # Class: (function-activating GABA-A receptor binding disposition) AnnotationAssertion( "function-activating gamma amino butyric acid (GABA)-A receptor binding disposition"@en) AnnotationAssertion( "A dispostion of a molecule to bind a GABA-A receptor in the pocket formed at the junction of the alpha and gamma subunits of the receptor in such a way as to increase the flow of chloride anions through the channel in the receptor, ultimately resulting in enhanced activity of GABA binding to the GABA-A receptor."@en) AnnotationAssertion( "William R. Hogan"@en) AnnotationAssertion(rdfs:comment "This is the mechanism of action of benzodiazepine drugs"@en) AnnotationAssertion(rdfs:label "function-activating GABA-A receptor binding disposition"@en) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (hormone therapeutic function) AnnotationAssertion( "A drug product therapeutic function that, if realized, is realized by the regulation of some endocrine process."@en) AnnotationAssertion( "Matthew Diller"@en) AnnotationAssertion(dce:contributor "Mathias Brochhausen"@en) AnnotationAssertion(dce:contributor "S. Clint Dowland"@en) AnnotationAssertion(dce:contributor "Sarah Bost"@en) AnnotationAssertion(dce:contributor "William R. Hogan"@en) AnnotationAssertion(rdfs:label "hormone therapeutic function"@en) SubClassOf( ) # Class: (albendazole tablet) AnnotationAssertion(dce:creator "Baxter Bramblett"@en) AnnotationAssertion(rdfs:label "albendazole tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (gentian violet solution) AnnotationAssertion(dce:creator "Baxter Bramblett") AnnotationAssertion(rdfs:label "gentian violet solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (ciprofloxacin tablet) AnnotationAssertion(dce:creator "Baxter Bramblett") AnnotationAssertion(rdfs:label "ciprofloxacin tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (amitriptyline tablet) AnnotationAssertion(dce:creator "Baxter Bramblett") AnnotationAssertion(rdfs:label "amitriptyline tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (cetirizine tablet) AnnotationAssertion(dce:creator "Baxter Bramblett") AnnotationAssertion(rdfs:label "cetirizine tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (diphenhydramine tablet) AnnotationAssertion(dce:creator "Baxter Bramblett") AnnotationAssertion(rdfs:label "diphenhydramine tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (salbutamol tablet) AnnotationAssertion( "albuterol tablet"@en) AnnotationAssertion(dce:creator "Baxter Bramblett"@en) AnnotationAssertion(rdfs:label "salbutamol tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (tetracycline eye ointment) AnnotationAssertion(dce:creator "Baxter Bramblett") AnnotationAssertion(rdfs:label "tetracycline eye ointment"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (cloxacillin suspension) AnnotationAssertion(dce:creator "Baxter Bramblett") AnnotationAssertion(rdfs:label "cloxacillin suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (promethazine suspension) AnnotationAssertion(dce:creator "Baxter Bramblett") AnnotationAssertion(rdfs:label "promethazine suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (sulfadoxine / pyrimethamine tablet) AnnotationAssertion( "fansidar tablet"@en) AnnotationAssertion(dce:creator "Baxter Bramblett"@en) AnnotationAssertion(rdfs:label "sulfadoxine / pyrimethamine tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (hydrocortisone skin ointment) AnnotationAssertion(dce:creator "Baxter Bramblett"@en) AnnotationAssertion(rdfs:label "hydrocortisone skin ointment"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (miconazole / clobetasol / gentamicin cream) AnnotationAssertion( "miconazole, clobetasol, gentamycin cream"@en) AnnotationAssertion(dce:creator "Baxter Bramblett"@en) AnnotationAssertion(rdfs:label "miconazole / clobetasol / gentamicin cream"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (mupirocin cream) AnnotationAssertion(dce:creator "Rodel Enderez"@en) AnnotationAssertion(rdfs:label "mupirocin cream"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (magnesium trisilicate suspension) AnnotationAssertion(rdfs:label "magnesium trisilicate suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (vitamin a capsule) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "vitamin a capsule"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (chloramphenical suspension) AnnotationAssertion( "chloramphenicol syrup"@en) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "chloramphenical suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (amoxicillin suspension) AnnotationAssertion( "amoxicillin syrup"@en) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "amoxicillin suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (betamethasone skin ointment) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "betamethasone skin ointment"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (clindamycin capsule) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "clindamycin capsule"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (diclofenac tablet) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "diclofenac tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (loperamide tablet) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "loperamide tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (nystatin capsule) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "nystatin capsule"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (ampicillin / cloxacillin capsule) AnnotationAssertion( "ampiclox capsule"@en) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "ampicillin / cloxacillin capsule"@en) EquivalentClasses( ObjectIntersectionOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )))))) SubClassOf( ) # Class: (chlorpheniramine tablet) AnnotationAssertion(dce:creator "Rodel Enderez") AnnotationAssertion(rdfs:label "chlorpheniramine tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Benzyl penicillin injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Benzyl penicillin injectable solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (magnesium trisilicate tablet) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "magnesium trisilicate tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Quinine tablet) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Quinine tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Glycerin borax solution) AnnotationAssertion( "Glycerin borax drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Glycerin borax solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Folic acid tablet) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Folic acid tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Betamethasone / neomycin skin cream) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Betamethasone / neomycin skin cream"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Clotrimazole skin cream) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Clotrimazole skin cream"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Erythromycin suspension) AnnotationAssertion( "Erythromycin syrup") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Erythromycin suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Mebendazole tablet) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Mebendazole tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Nystatin suspension) AnnotationAssertion( "Nystatin oral drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Nystatin suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Ampicillin / cloxacillin suspension) AnnotationAssertion( "Ampiclox syrup") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Ampicillin / cloxacillin suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Mefenamic acid tablet) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Mefenamic acid tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Gentamicin solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Gentamicin solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Gentamicin solution for otic and ophthalmic administration) AnnotationAssertion( "Gentamicin eye/ear drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Gentamicin solution for otic and ophthalmic administration"@en) SubClassOf( ) # Class: (Gentamicin injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Gentamicin injectable solution"@en) SubClassOf( ) # Class: (Dexamethasone solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Dexamethasone solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Dexamethasone solution for otic and ophthalmic administration) AnnotationAssertion( "Dexona eye/ear drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Dexamethasone solution for otic and ophthalmic administration"@en) SubClassOf( ) # Class: (Dexamethasone injection) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Dexamethasone injection"@en) SubClassOf( ) # Class: (Ciprofloxacin solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Ciprofloxacin solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Ciprofloxacin solution for otic administration) AnnotationAssertion( "Ciprofloxacin ear drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Ciprofloxacin solution for otic administration"@en) SubClassOf( ) # Class: (Ciprofloxacin injectable solution) AnnotationAssertion(rdfs:label "Ciprofloxacin injectable solution"@en) SubClassOf( ) # Class: (Quinine injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Quinine injectable solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Chloramphenicol solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Chloramphenicol solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Chloramphenicol solution for otic and ophthalmic administration) AnnotationAssertion( "Chloramphenicol eye/ear drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Chloramphenicol solution for otic and ophthalmic administration"@en) SubClassOf( ) # Class: (Chloramphenicol injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Chloramphenicol injectable solution"@en) SubClassOf( ) # Class: (Bleomycin injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Bleomycin injectable solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Ceftriaxone injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasoncelos") AnnotationAssertion(rdfs:label "Ceftriaxone injectable solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Betamethasone solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Betamethasone solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Betamethasone solution for ophthalmic administration) AnnotationAssertion( "Betamethasone eye drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Betamethasone solution for ophthalmic administration"@en) SubClassOf( ) # Class: (Betamethasone injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Betamethasone injectable solution"@en) SubClassOf( ) # Class: (Betamethasone / neomycin solution for ophthalmic administration) AnnotationAssertion( "Betamethasone / neomycin eye drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Betamethasone / neomycin solution for ophthalmic administration"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Hydrocortisone solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Hydrocortisone solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Hydrocortisone solution for otic and ophthalmic administration) AnnotationAssertion( "Hydrocortisone eye/ear drop") AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Hydrocortisone solution for otic and ophthalmic administration"@en) SubClassOf( ) # Class: (Hydrocortisone injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Hydrocortisone injectable solution"@en) SubClassOf( ) # Class: (Chloroquine solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Chloroquine solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Chloroquine injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Chloroquine injectable solution"@en) SubClassOf( ) # Class: (Diclofenac solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Diclofenac solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Diclofenac injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Diclofenac injectable solution"@en) SubClassOf( ) # Class: (Metronidazole solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Metronidazole solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Metronidazole injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Metronidazole injectable solution"@en) SubClassOf( ) # Class: (Oxytocin solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Oxytocin solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Oxytocin injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Oxytocin injectable solution"@en) SubClassOf( ) # Class: (Promethazine solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Promethazine solution"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Promethazine injectable solution) AnnotationAssertion(dce:creator "Mirela L Vasconcelos") AnnotationAssertion(rdfs:label "Promethazine injectable solution"@en) SubClassOf( ) # Class: (terbinafine tablet) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "terbinafine tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (tenofovir / emtricitabine tablet) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "tenofovir / emtricitabine tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )))))) SubClassOf( ) # Class: (hydrocortisone skin cream) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "hydrocortisone skin cream"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (acyclovir cream) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "acyclovir cream"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (tetracycline capsule) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "tetracycline capsule"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (cephalexin suspension) AnnotationAssertion( "cephalexin syrup"@en) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "cephalexin suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (fluconazole capsule) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "fluconazole capsule"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (cloxacillin capsule) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "cloxacillin capsule"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (metronidazole tablet) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "metronidazole tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (prednisolone tablet) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "prednisolone tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (ampicillin / clavulanate tablet) AnnotationAssertion( "augmentin tablet"@en) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "ampicillin / clavulanate tablet"@en) EquivalentClasses( ObjectIntersectionOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )))))) SubClassOf( ) # Class: (salbutamol suspension) AnnotationAssertion( "salbutamol syrup"@en) AnnotationAssertion(dce:creator "Matthew Diller") AnnotationAssertion(rdfs:label "salbutamol suspension"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))))) SubClassOf( ) # Class: (Hydroflumethiazide Oral Tablet) SubClassOf( ObjectSomeValuesFrom( )) # Class: (quinethazone Oral Tablet) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Hydroflumethiazide / Reserpine Oral Tablet) SubClassOf( ObjectSomeValuesFrom( )) # Class: (quinethazone / Reserpine Oral Tablet) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Hydroflumethiazide / Spironolactone Oral Tablet) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Ethacrynate Oral Tablet) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Hydroflumethiazide / Potassium / Rauwolfia preparation Oral Tablet) SubClassOf( ObjectSomeValuesFrom( )) # Class: (mepolizumab) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Zolazepam) SubClassOf( ObjectSomeValuesFrom( )) # Class: (binding) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) # Class: (protein binding) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) # Class: (biological_process) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) SubClassOf( ) # Class: (enzyme binding) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) # Class: (multicellular organismal process) AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) # Class: (endocrine process) AnnotationAssertion( ) # Class: () AnnotationAssertion( ) # Class: () AnnotationAssertion( ) # Class: (planned process) AnnotationAssertion( ) # Class: (processed material) AnnotationAssertion( ) # Class: (scattered molecular aggregate) AnnotationAssertion( ) # Class: (organism) AnnotationAssertion( ) # Class: (treatment) SubClassOf( ) # Class: () AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) ############################ # Named Individuals ############################ # Individual: () AnnotationAssertion( ) AnnotationAssertion( "ciara lusnia") )