Drosophila Developmental Ontology
type: Ontology
version IRI: fbdv-non-classified.owl
IAO_0000700: Drosophila life
IAO_0000700: developmental stage
IAO_0000700: age
IAO_0000700: biological process
creator: http://orcid.org/0000-0002-1373-1705
creator: http://orcid.org/0000-0002-7073-9172
creator: https://orcid.org/0000-0001-5948-3092
creator: https://orcid.org/0000-0002-0027-0858
description: An ontology of Drosophila melanogaster developmental stages.
license: https://creativecommons.org/licenses/by/4.0/
namespace-id-rule: * FBdv:$sequence(8,7000,10000)$
date: 18:04:2024 09:08
default-namespace: FlyBase_development_CV
has_obo_format_version: 1.2
version info: 2024-04-18

definition
type: AnnotationProperty

term replaced by
type: AnnotationProperty

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck do not manually annotate
type: AnnotationProperty
comment: Term not to be used for direct manual annotation
sub property of: subset_property

goslim ChEMBL
type: AnnotationProperty
comment: ChEMBL GO slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL GO slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

gosubset prok
type: AnnotationProperty
comment: Prokaryotic GO subset
sub property of: subset_property

namespace-id-rule
type: AnnotationProperty

subset_property
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

id
type: AnnotationProperty

part of
type: ObjectProperty
sub property of: overlaps
inverse of: has part
type: TransitiveProperty
definition: a core relation that holds between a part and its whole

has part
type: ObjectProperty
sub property of: overlaps
type: TransitiveProperty
definition: a core relation that holds between a whole and its part

preceded by
type: ObjectProperty
sub property of: ends after
inverse of: precedes
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: starts during
property chain axiom: happens during
definition: x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.

precedes
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: happens during
definition: x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.

substage of
type: ObjectProperty
sub property of: occurrent part of
sub property of: happens during
type: TransitiveProperty
definition: A relation between a developmental stage and another, larger developmental stage during which it happens.
has_obo_namespace: relationship
id: FBdv:00018001
comment: Creating this relation as a temporary fix, pending adding the axiom occurrent_part_of subproperty of happens_during to RO.

Axiom
annotated source: substage of
annotated property: definition
annotated target: A relation between a developmental stage and another, larger developmental stage during which it happens.
database_cross_reference: FBC:DPG

characteristic of
type: ObjectProperty
sub property of: characteristic of part of
inverse of: has characteristic
type: FunctionalProperty
definition: a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.

has characteristic
type: ObjectProperty
type: InverseFunctionalProperty
range: specifically dependent continuant
definition: Inverse of characteristic_of

participates in
type: ObjectProperty
inverse of: has participant
domain: continuant
range: occurrent
definition: a relation between a continuant and a process, in which the continuant is somehow involved in the process

has participant
type: ObjectProperty
domain: occurrent
range: continuant
property chain axiom: has part
definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process

function of
type: ObjectProperty
sub property of: characteristic of
inverse of: has function
domain: function
definition: a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.

quality of
type: ObjectProperty
sub property of: characteristic of
inverse of: has quality
definition: a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.

role of
type: ObjectProperty
sub property of: characteristic of
inverse of: has role
definition: a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.

has function
type: ObjectProperty
sub property of: has characteristic
domain: independent continuant
range: function
definition: a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence

has quality
type: ObjectProperty
sub property of: has characteristic
range: quality
definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence

has role
type: ObjectProperty
sub property of: has characteristic
domain: independent continuant
range: role
definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence

has disposition
type: ObjectProperty
sub property of: has characteristic
inverse of: disposition of
domain: independent continuant
range: disposition
definition: a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence

disposition of
type: ObjectProperty
sub property of: characteristic of
definition: inverse of has disposition
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.

occurrent part of
type: ObjectProperty
sub property of: part of
sub property of: causally upstream of or within
domain: occurrent
range: occurrent
definition: A part of relation that applies only between occurrents.

has regulatory component activity
type: ObjectProperty
sub property of: has component activity
sub property of: regulated by
definition: A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.

has negative regulatory component activity
type: ObjectProperty
sub property of: has regulatory component activity
sub property of: negatively regulated by
definition: A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
comment: By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.

has positive regulatory component activity
type: ObjectProperty
sub property of: has regulatory component activity
sub property of: positively regulated by
definition: A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.

has component activity
type: ObjectProperty
sub property of: has component process
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.

has component process
type: ObjectProperty
sub property of: has component
domain: process
range: process
definition: w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.

directly regulated by
type: ObjectProperty
sub property of: regulated by
inverse of: directly regulates
comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.

Axiom
annotated source: directly regulated by
annotated property: comment
annotated target: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
database_cross_reference: https://orcid.org/0000-0002-7073-9172

directly negatively regulated by
type: ObjectProperty
sub property of: directly regulated by
inverse of: directly negatively regulates
definition: Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.

Axiom
annotated source: directly negatively regulated by
annotated property: definition
annotated target: Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
database_cross_reference: https://orcid.org/0000-0002-7073-9172

directly positively regulated by
type: ObjectProperty
sub property of: directly regulated by
inverse of: directly positively regulates
definition: Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.

Axiom
annotated source: directly positively regulated by
annotated property: definition
annotated target: Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
database_cross_reference: https://orcid.org/0000-0002-7073-9172

has effector activity
type: ObjectProperty
sub property of: has component activity
type: FunctionalProperty
definition: A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.

Axiom
annotated source: has effector activity
annotated property: definition
annotated target: A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
database_cross_reference: https://orcid.org/0000-0002-7073-9172

during which ends
type: ObjectProperty
sub property of: temporally related to
inverse of: ends during
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002122 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

encompasses
type: ObjectProperty
sub property of: during which starts
inverse of: happens during
type: TransitiveProperty
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002124 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

ends after
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
property chain axiom: ends during
property chain axiom: preceded by
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)

immediately preceded by
type: ObjectProperty
sub property of: preceded by
inverse of: immediately precedes
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)

during which starts
type: ObjectProperty
sub property of: temporally related to
inverse of: starts during
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002123 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

immediately precedes
type: ObjectProperty
sub property of: precedes
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)

starts during
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
comment: X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))

happens during
type: ObjectProperty
sub property of: starts during
sub property of: ends during
type: TransitiveProperty
comment: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))

ends during
type: ObjectProperty
sub property of: temporally related to
comment: X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).

overlaps
type: ObjectProperty
sub property of: mereotopologically related to
type: SymmetricProperty
property chain axiom: part of
property chain axiom: has part
definition: x overlaps y if and only if there exists some z such that x has part z and z part of y

has component
type: ObjectProperty
sub property of: has part
definition: w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.

develops from
type: ObjectProperty
sub property of: has developmental contribution from
sub property of: developmentally preceded by
inverse of: develops into
type: TransitiveProperty
domain: independent continuant
range: independent continuant
definition: x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
comment: This is the transitive form of the develops from relation

develops into
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to develop into
sub property of: has potential to directly develop into
type: TransitiveProperty
definition: inverse of develops from

regulates
type: ObjectProperty
sub property of: causally upstream of
inverse of: regulated by
type: TransitiveProperty
domain: process
range: process
property chain axiom: has effector activity
property chain axiom: directly regulates
definition: p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q.

negatively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, negative effect
inverse of: negatively regulated by
definition: p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q.

positively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, positive effect
inverse of: positively regulated by
type: TransitiveProperty
property chain axiom: negatively regulates
definition: p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q.

capable of
type: ObjectProperty
sub property of: capable of part of
domain: independent continuant
range: process
definition: A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.

capable of part of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal agent in process
definition: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.

temporally related to
type: ObjectProperty
domain: occurrent
range: occurrent
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.

has input
type: ObjectProperty
sub property of: has participant
inverse of: input of
domain: process
definition: p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.

has developmental contribution from
type: ObjectProperty
sub property of: developmentally preceded by
inverse of: developmentally contributes to
property chain axiom: has part
property chain axiom: develops from
definition: x has developmental contribution from y iff x has some part z such that z develops from y

developmentally contributes to
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to developmentally contribute to
property chain axiom: develops into
property chain axiom: part of
definition: inverse of has developmental contribution from

developmentally preceded by
type: ObjectProperty
sub property of: developmentally related to
inverse of: developmentally succeeded by
domain: continuant
range: continuant
definition: Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from

acts upstream of
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of
definition: c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes.

acts upstream of or within
type: ObjectProperty
sub property of: causal agent in process
property chain axiom: enables
property chain axiom: causally upstream of or within
definition: c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.
has_related_synonym: affects

developmentally succeeded by
type: ObjectProperty
sub property of: has developmental potential involving
definition: Inverse of developmentally preceded by

causally upstream of, positive effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, positive effect
definition: p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q.
comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y

causally upstream of, negative effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, negative effect
definition: p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q.

characteristic of part of
type: ObjectProperty
sub property of: depends on
property chain axiom: part of
definition: q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.

mereotopologically related to
type: ObjectProperty
definition: A mereological relationship or a topological relationship

developmentally related to
type: ObjectProperty
definition: A relationship that holds between entities participating in some developmental process (GO:0032502)

enables
type: ObjectProperty
sub property of: capable of
inverse of: enabled by
property chain axiom: has part
property chain axiom: has component activity
definition: c enables p iff c is capable of p and c acts to execute p.

functionally related to
type: ObjectProperty
definition: A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.

part of structure that is capable of
type: ObjectProperty
sub property of: functionally related to
definition: this relation holds between c and p when c is part of some c', and c' is capable of p.

involved in
type: ObjectProperty
sub property of: participates in
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: part of
definition: c involved_in p if and only if c enables some process p', and p' is part of p

enabled by
type: ObjectProperty
sub property of: has participant
sub property of: functionally related to
definition: inverse of enables

regulated by
type: ObjectProperty
sub property of: causally downstream of or within
type: TransitiveProperty
domain: process
range: process
definition: inverse of regulates

negatively regulated by
type: ObjectProperty
sub property of: regulated by
definition: inverse of negatively regulates

positively regulated by
type: ObjectProperty
sub property of: regulated by
definition: inverse of positively regulates

input of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
definition: inverse of has input

has developmental potential involving
type: ObjectProperty
sub property of: developmentally related to
definition: x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).

has potential to developmentally contribute to
type: ObjectProperty
sub property of: has developmental potential involving
definition: x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y

has potential to develop into
type: ObjectProperty
sub property of: has developmental potential involving
definition: x has the potential to develop into y iff x develops into y or if x is capable of developing into y

has potential to directly develop into
type: ObjectProperty
sub property of: has potential to develop into
definition: x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y

causally downstream of
type: ObjectProperty
sub property of: preceded by
sub property of: causally downstream of or within
inverse of: causally upstream of
definition: inverse of upstream of

immediately causally downstream of
type: ObjectProperty
sub property of: immediately preceded by
sub property of: causally downstream of
inverse of: immediately causally upstream of

indirectly positively regulates
type: ObjectProperty
sub property of: positively regulates
sub property of: indirectly regulates
type: TransitiveProperty
property chain axiom: directly positively regulates
property chain axiom: indirectly negatively regulates
definition: p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q.

indirectly negatively regulates
type: ObjectProperty
sub property of: negatively regulates
sub property of: indirectly regulates
type: TransitiveProperty
property chain axiom: directly negatively regulates
definition: p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q.

causally related to
type: ObjectProperty
definition: relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause.

Axiom
annotated source: causally related to
annotated property: definition
annotated target: relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause.
database_cross_reference: https://en.wikipedia.org/wiki/Causality

causally upstream of
type: ObjectProperty
sub property of: precedes
sub property of: causally upstream of or within
type: TransitiveProperty
definition: p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q.

immediately causally upstream of
type: ObjectProperty
sub property of: immediately precedes
sub property of: causally upstream of
definition: p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q.

causally upstream of or within
type: ObjectProperty
sub property of: causal relation between processes
inverse of: causally downstream of or within
type: TransitiveProperty
definition: p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q.
has_related_synonym: affects

causally downstream of or within
type: ObjectProperty
sub property of: causal relation between processes
type: TransitiveProperty
definition: inverse of causally upstream of or within

involved in regulation of
type: ObjectProperty
sub property of: acts upstream of
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' regulates some p

involved in positive regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: positively regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' positively regulates some p

involved in negative regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: negatively regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' negatively regulates some p

involved in or involved in regulation of
type: ObjectProperty
sub property of: acts upstream of or within
sub property of: functionally related to
sub property of: causal agent in process
definition: c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p

interacts with
type: ObjectProperty
type: SymmetricProperty
domain: material entity
range: material entity
definition: A relationship that holds between two entities in which the processes executed by the two entities are causally connected.
has_exact_synonym: in pairwise interaction with

molecularly interacts with
type: ObjectProperty
sub property of: interacts with
type: SymmetricProperty
definition: An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.

phosphorylates
type: ObjectProperty
sub property of: molecularly interacts with

directly regulates activity of
type: ObjectProperty
sub property of: molecularly interacts with
sub property of: regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.
has_exact_synonym: molecularly controls

directly negatively regulates activity of
type: ObjectProperty
sub property of: directly regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: directly negatively regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.
has_exact_synonym: molecularly decreases activity of

directly positively regulates activity of
type: ObjectProperty
sub property of: directly regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: directly positively regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.
has_exact_synonym: molecularly increases activity of

helper property (not for use in curation)
type: ObjectProperty

is kinase activity
type: ObjectProperty
sub property of: molecular interaction relation helper property

causal agent in process
type: ObjectProperty
sub property of: causal relation between material entity and a process
inverse of: process has causal agent
definition: A relationship between a material entity and a process where the material entity has some causal role that influences the process

causal relation between processes
type: ObjectProperty
sub property of: causally related to
domain: occurrent
range: occurrent
definition: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q.

depends on
type: ObjectProperty

causal relation between entities
type: ObjectProperty
sub property of: causally related to
domain: continuant
range: continuant

causally influenced by
type: ObjectProperty
sub property of: causal relation between entities
inverse of: causally influences

interaction relation helper property
type: ObjectProperty
sub property of: helper property (not for use in curation)

molecular interaction relation helper property
type: ObjectProperty
sub property of: interaction relation helper property

causally influences
type: ObjectProperty
sub property of: causal relation between entities
domain: continuant
range: continuant
property chain axiom: enables
property chain axiom: causally upstream of
property chain axiom: has input
property chain axiom: enabled by
definition: The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).

directly regulates
type: ObjectProperty
sub property of: regulates
sub property of: immediately causally upstream of
definition: p directly regulates q iff p is immediately causally upstream of q and p regulates q.

has part structure that is capable of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal relation between material entity and a process
property chain axiom: has part
property chain axiom: capable of
definition: s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p

causal relation between material entity and a process
type: ObjectProperty
sub property of: causally related to
domain: material entity
range: process
definition: A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.

capable of regulating
type: ObjectProperty
sub property of: causal agent in process
property chain axiom: capable of
property chain axiom: regulates
definition: Holds between c and p if and only if c is capable of some activity a, and a regulates p.

capable of negatively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: negatively regulates
definition: Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.

capable of positively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: positively regulates
definition: Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.

process has causal agent
type: ObjectProperty
sub property of: causally related to
definition: Inverse of 'causal agent in process'

directly positively regulates
type: ObjectProperty
sub property of: positively regulates
sub property of: directly regulates
definition: p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q.

directly negatively regulates
type: ObjectProperty
sub property of: negatively regulates
sub property of: directly regulates
definition: p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q.

enables subfunction
type: ObjectProperty
sub property of: functionally related to
property chain axiom: enables
property chain axiom: has part
definition: Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P.

acts upstream of or within, positive effect
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of or within, positive effect

acts upstream of or within, negative effect
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of or within, negative effect

acts upstream of, positive effect
type: ObjectProperty
sub property of: acts upstream of
sub property of: acts upstream of or within, positive effect
property chain axiom: enables
property chain axiom: causally upstream of, positive effect
definition: c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive

acts upstream of, negative effect
type: ObjectProperty
sub property of: acts upstream of
sub property of: acts upstream of or within, negative effect
property chain axiom: enables
property chain axiom: causally upstream of, negative effect
definition: c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative

causally upstream of or within, negative effect
type: ObjectProperty
sub property of: causally upstream of or within

causally upstream of or within, positive effect
type: ObjectProperty
sub property of: causally upstream of or within

regulates activity of
type: ObjectProperty
sub property of: causally influences
domain: material entity
range: material entity
definition: The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.

indirectly causally upstream of
type: ObjectProperty
sub property of: causally upstream of
definition: p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q.

indirectly regulates
type: ObjectProperty
sub property of: regulates
sub property of: indirectly causally upstream of
definition: p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q.

device utilizes material
type: ObjectProperty
property chain axiom: capable of
property chain axiom: has input
definition: X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y.
has_broad_synonym: utilizes

regulates characteristic
type: ObjectProperty
sub property of: causally related to
domain: process
property chain axiom: regulates
definition: A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C.
contributor: https://orcid.org/0000-0002-8688-6599

positively regulates characteristic
type: ObjectProperty
sub property of: regulates characteristic
property chain axiom: positively regulates
definition: A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C.
contributor: https://orcid.org/0000-0002-8688-6599

negatively regulates characteristic
type: ObjectProperty
sub property of: regulates characteristic
property chain axiom: negatively regulates
property chain axiom: positively regulates characteristic
property chain axiom: positively regulates
definition: A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C.
contributor: https://orcid.org/0000-0002-8688-6599

continuant
type: Class
subclass of: Restriction
  on property: part of
  all values from: continuant
disjoint with: occurrent
disjoint with: Restriction
  on property: part of
  some values from: occurrent
definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.

occurrent
type: Class
subclass of: Restriction
  on property: part of
  all values from: occurrent
disjoint with: Restriction
  on property: part of
  some values from: continuant
definition: An entity that has temporal parts and that happens, unfolds or develops through time.

independent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: independent continuant
disjoint with: specifically dependent continuant
definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.

process
type: Class
subclass of: occurrent
definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.

disposition
type: Class
subclass of: realizable entity
disjoint with: role

realizable entity
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: realizable entity
disjoint with: quality
definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.

quality
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: quality

specifically dependent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: specifically dependent continuant
definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.

role
type: Class
subclass of: realizable entity
definition: A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.

function
type: Class
subclass of: disposition

material entity
type: Class
subclass of: independent continuant
definition: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.

Drosophila life
type: Class
subclass of: occurrent
definition: The life of an individual of the species Drosophila melanogaster, from fertilization to death.
has_alternative_id: FBdv_root:00000000
has_exact_synonym: Drosophila life cycle
has_obo_namespace: FlyBase_development_CV
id: FBdv:00000000

Axiom
annotated source: Drosophila life
annotated property: definition
annotated target: The life of an individual of the species Drosophila melanogaster, from fertilization to death.
database_cross_reference: FBC:DOS

cleavage stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: fertilized egg stage
definition: A collective term for stages 1-4.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00000054
comment: Temporal ordering number - 25.

Axiom
annotated source: cleavage stage
annotated property: definition
annotated target: A collective term for stages 1-4.
database_cross_reference: FBC:DOS

late extended germ band stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 10
subclass of: Restriction
  on property: immediately preceded by
  some values from: early extended germ band stage
definition: A collective term for stages 11 and 12.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00004450
comment: Temporal ordering number - 300.

Axiom
annotated source: late extended germ band stage
annotated property: definition
annotated target: A collective term for stages 11 and 12.
database_cross_reference: FBC:DOS

oogenesis
type: Class
subclass of: developmental process
definition: The complete process of formation and maturation of an ovum or female gemate from a primordial female germ cell.
database_cross_reference: GO:0048477
has_exact_synonym: oogenesis stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00004886
comment: Temporal ordering number - 10000.

Axiom
annotated source: oogenesis
annotated property: definition
annotated target: The complete process of formation and maturation of an ovum or female gemate from a primordial female germ cell.
database_cross_reference: GO:0048477

developmental stage
type: Class
subclass of: occurrent
definition: A temporal subdivision of a developmental process.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2009-10-01T05:56:56Z
has_alternative_id: FBdv:00007010
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005259

Axiom
annotated source: developmental stage
annotated property: definition
annotated target: A temporal subdivision of a developmental process.
database_cross_reference: FBC:DOS

oogenesis stage S1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
definition: Earliest stage of ovarian cyst development - lasts while the 16 cell cyst is within the germarium (region 3).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005261
comment: Temporal ordering number - 10010.

Axiom
annotated source: oogenesis stage S1
annotated property: definition
annotated target: Earliest stage of ovarian cyst development - lasts while the 16 cell cyst is within the germarium (region 3).
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S1
definition: Oogenesis stage that begins when the cyst leaves the germarium (from this point the cyst is referred to as an egg chamber). During this stage, polyploidation of the nurse cells begins, they reach a ploidy of 8C, and follicle cells start to divide.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005262
comment: Temporal ordering number - 10020.

Axiom
annotated source: oogenesis stage S2
annotated property: definition
annotated target: Oogenesis stage that begins when the cyst leaves the germarium (from this point the cyst is referred to as an egg chamber). During this stage, polyploidation of the nurse cells begins, they reach a ploidy of 8C, and follicle cells start to divide.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S3
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S2
definition: Oogenesis stage that begins when the oocyte chromosomes condense into a karyosome attached to a distinctive spherical structure known as an endobody. The oocyte nucleolus disappears completely. During this stage, nurse cell ploidy reaches 16C.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005263
comment: Temporal ordering number - 10030.

Axiom
annotated source: oogenesis stage S3
annotated property: definition
annotated target: Oogenesis stage that begins when the oocyte chromosomes condense into a karyosome attached to a distinctive spherical structure known as an endobody. The oocyte nucleolus disappears completely. During this stage, nurse cell ploidy reaches 16C.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S4
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S3
definition: Oogenesis stage that begins when the nurse cells chromosomes become bulbous. Nurse cell chromosomes during this stage are polytene and reach a ploidy of 32C. The egg chamber is oval shaped.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005264
comment: Temporal ordering number - 10040.

Axiom
annotated source: oogenesis stage S4
annotated property: definition
annotated target: Oogenesis stage that begins when the nurse cells chromosomes become bulbous. Nurse cell chromosomes during this stage are polytene and reach a ploidy of 32C. The egg chamber is oval shaped.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S5
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S4
definition: Oogenesis stage that begins when nurse cell chromosomes are no longer bulbous - the association between homologs weakens so that these chromosomes no longer have a polytene structure. During this stage, posterior nurse cell nuclei have a higher ploidy (64C) than anterior ones.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005265
comment: Temporal ordering number - 10050.

Axiom
annotated source: oogenesis stage S5
annotated property: definition
annotated target: Oogenesis stage that begins when nurse cell chromosomes are no longer bulbous - the association between homologs weakens so that these chromosomes no longer have a polytene structure. During this stage, posterior nurse cell nuclei have a higher ploidy (64C) than anterior ones.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S6
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S5
definition: Oogenesis stage during which follicle cell division ceases.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005266
comment: Temporal ordering number - 10060.

Axiom
annotated source: oogenesis stage S6
annotated property: definition
annotated target: Oogenesis stage during which follicle cell division ceases.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S7
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S6
definition: Oogenesis stage during which polyploidation and enlargement of follicle cells begins. Nurse cell ploidy ranges from 256C (anterior) to 512C (posterior) and the egg chamber gains an elongated shape.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005267
comment: Temporal ordering number - 10070.

Axiom
annotated source: oogenesis stage S7
annotated property: definition
annotated target: Oogenesis stage during which polyploidation and enlargement of follicle cells begins. Nurse cell ploidy ranges from 256C (anterior) to 512C (posterior) and the egg chamber gains an elongated shape.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S8
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S7
definition: Oogenesis stage which begins when yolk first appears in the oocyte. Follicle cell migration over the oocyte begins during this stage (although mostly occurs during stage 9).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005268
comment: Temporal ordering number - 10080.

Axiom
annotated source: oogenesis stage S8
annotated property: definition
annotated target: Oogenesis stage which begins when yolk first appears in the oocyte. Follicle cell migration over the oocyte begins during this stage (although mostly occurs during stage 9).
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S9
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S8
definition: Oogenesis stage that begins when the border cells begin to migrate. During this stage: the oocyte is about 1/3 the length of the egg chamber with its nucleus located antero-dorsally; follicle cell migration results in an anterior to posterior gradient of follicle cell thickness with posterior cells being thicker (-> columnar) and posterior cells thinner ( -> squamous); border cell migration begins and ends; secretion of vitelline membrane begins.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005269
comment: Temporal ordering number - 10090.

Axiom
annotated source: oogenesis stage S9
annotated property: definition
annotated target: Oogenesis stage that begins when the border cells begin to migrate. During this stage: the oocyte is about 1/3 the length of the egg chamber with its nucleus located antero-dorsally; follicle cell migration results in an anterior to posterior gradient of follicle cell thickness with posterior cells being thicker (-> columnar) and posterior cells thinner ( -> squamous); border cell migration begins and ends; secretion of vitelline membrane begins.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S10
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S9
definition: Oogenesis stage that begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends with the beginning of nurse cell dumping.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005270
comment: Temporal ordering number - 10100.

Axiom
annotated source: oogenesis stage S10
annotated property: definition
annotated target: Oogenesis stage that begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends with the beginning of nurse cell dumping.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S10A
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S10
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S9
definition: Oogenesis stage which begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends when centripetal follicle migration begins. During this stage, the migrating border cells reach the oocyte. The oocyte is about 50% egg chamber length.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005271
comment: Temporal ordering number - 10110.

Axiom
annotated source: oogenesis stage S10A
annotated property: definition
annotated target: Oogenesis stage which begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends when centripetal follicle migration begins. During this stage, the migrating border cells reach the oocyte. The oocyte is about 50% egg chamber length.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074

oogenesis stage S10B
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S10
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S10A
definition: Oogenesis stage that begins when the centripetal follicle cells begin to migrate. As a result, the vitelline membrane extends into the opercular region. This stage ends when nurse cell dumping begins.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005272
comment: Temporal ordering number - 10120.

Axiom
annotated source: oogenesis stage S10B
annotated property: definition
annotated target: Oogenesis stage that begins when the centripetal follicle cells begin to migrate. As a result, the vitelline membrane extends into the opercular region. This stage ends when nurse cell dumping begins.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S11
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S10
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S10B
definition: Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins. The dorsal appendages begin to form during this stage. This stage ends when dying nurse cells form an anterior cap to the oocyte.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005273
comment: Temporal ordering number - 10130.

Axiom
annotated source: oogenesis stage S11
annotated property: definition
annotated target: Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins. The dorsal appendages begin to form during this stage. This stage ends when dying nurse cells form an anterior cap to the oocyte.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0043885
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S12
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S11
definition: Oogenesis stage that begins when dying nurse cells form an anterior cap to the oocyte. Shortly after this, nurse cell dumping and growth of the oocyte are complete. Elongation of the dorsal appendages and formation of the innermost chorionic layer and endochorion begins during this stage.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005274
comment: Temporal ordering number - 10160.

Axiom
annotated source: oogenesis stage S12
annotated property: definition
annotated target: Oogenesis stage that begins when dying nurse cells form an anterior cap to the oocyte. Shortly after this, nurse cell dumping and growth of the oocyte are complete. Elongation of the dorsal appendages and formation of the innermost chorionic layer and endochorion begins during this stage.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0043885
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S12A
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S12
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S11
definition: Innermost chorionic layer and endochorion begin to form in the anterior of the follicle.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005275
comment: Temporal ordering number - 10170.

Axiom
annotated source: oogenesis stage S12A
annotated property: definition
annotated target: Innermost chorionic layer and endochorion begin to form in the anterior of the follicle.
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S12B
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S12
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S12A
definition: Secretion of innermost chorionic layer and endochorion begins in the main follicle cells.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005276
comment: Temporal ordering number - 10180.

Axiom
annotated source: oogenesis stage S12B
annotated property: definition
annotated target: Secretion of innermost chorionic layer and endochorion begins in the main follicle cells.
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S12C
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S12
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S12B
definition: Formation of specialized endochorion structures in the anterior of the follicle: branches in the developing dorsal appendages; compact endochorion lacking the pillars seen in the rest of the follicle.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005277
comment: Temporal ordering number - 10190.

Axiom
annotated source: oogenesis stage S12C
annotated property: definition
annotated target: Formation of specialized endochorion structures in the anterior of the follicle: branches in the developing dorsal appendages; compact endochorion lacking the pillars seen in the rest of the follicle.
database_cross_reference: FlyBase:FBrf0021038

oogenesis stage S13
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S12
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S12C
definition: Oogenesis stage that begins when the micropyle begins to form. At the beginning of this stage, about 12-15 nurse cell nuclei remain at the anterior of the oocyte. By the end of this stage, none of these nuclei remain. Oocyte meiosis up to arrest at full metaphase I occurs during this stage.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005278
comment: Temporal ordering number - 10200.

Axiom
annotated source: oogenesis stage S13
annotated property: definition
annotated target: Oogenesis stage that begins when the micropyle begins to form. At the beginning of this stage, about 12-15 nurse cell nuclei remain at the anterior of the oocyte. By the end of this stage, none of these nuclei remain. Oocyte meiosis up to arrest at full metaphase I occurs during this stage.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0029744
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S13A
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S12C
definition: Oogenesis stage during which 12-15 nurse cell nuclei remain at the anterior of the oocyte. At this stage, the oocyte nucleus has reached its maximum volume and its chromosomes are compressed into a 5-7 micrometer karyosome.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005279
comment: Temporal ordering number - 10210. An alternative division of stage 13 into two sub-stages, A and B, has been defined on the basis of chorion development (see FBrf0043885). This ontology uses an alternative subdivision based on nurse cell nucleus number and oocyte meiosis, as the former at least, is easier to score than chorion ultrastructure.

Axiom
annotated source: oogenesis stage S13A
annotated property: definition
annotated target: Oogenesis stage during which 12-15 nurse cell nuclei remain at the anterior of the oocyte. At this stage, the oocyte nucleus has reached its maximum volume and its chromosomes are compressed into a 5-7 micrometer karyosome.
database_cross_reference: FlyBase:FBrf0029744

oogenesis stage S13B
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S13A
definition: Oogenesis stage during which 9-11 nurse cell nuclei remain at the anterior of the oocyte. During this stage, the nuclear membrane of the oocyte nucleus disappears, indicating the start of meiotic pro-metaphase.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005280
comment: Temporal ordering number - 10220. An alternative division of stage 13 into two sub-stages, A and B, has been defined on the basis of chorion development (see FBrf0043885). This ontology uses an alternative subdivision based on nurse cell nucleus number and oocyte meiosis, as the former at least, is easier to score than chorion ultrastructure.

Axiom
annotated source: oogenesis stage S13B
annotated property: definition
annotated target: Oogenesis stage during which 9-11 nurse cell nuclei remain at the anterior of the oocyte. During this stage, the nuclear membrane of the oocyte nucleus disappears, indicating the start of meiotic pro-metaphase.
database_cross_reference: FlyBase:FBrf0029744

oogenesis stage S13C
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S13B
definition: Oogenesis stage during which only 7-8 nurse cell nuclei remain at the anterior of the oocyte. At the beginning of this stage, oocyte chromosome bivalents separate from each other - indicating mid-prometaphase of oocyte meiosis.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005281
comment: Temporal ordering number - 10230.

Axiom
annotated source: oogenesis stage S13C
annotated property: definition
annotated target: Oogenesis stage during which only 7-8 nurse cell nuclei remain at the anterior of the oocyte. At the beginning of this stage, oocyte chromosome bivalents separate from each other - indicating mid-prometaphase of oocyte meiosis.
database_cross_reference: FlyBase:FBrf0029744

oogenesis stage S13D
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S13C
definition: Oogenesis stage during which only 5-6 nurse cell nuclei remain at the anterior of the oocyte. The oocyte nucleus is in late prometaphase:the bivalents arrange themselves in on the equatorial plane of the spindle; homologous centromeres are pulled towards the poles.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005282
comment: Temporal ordering number - 10240.

Axiom
annotated source: oogenesis stage S13D
annotated property: definition
annotated target: Oogenesis stage during which only 5-6 nurse cell nuclei remain at the anterior of the oocyte. The oocyte nucleus is in late prometaphase:the bivalents arrange themselves in on the equatorial plane of the spindle; homologous centromeres are pulled towards the poles.
database_cross_reference: FlyBase:FBrf0029744

oogenesis stage S14
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S13D
definition: The last stage of oogenesis. This stage begins when no nurse cell nuclei remain at the anterior of the egg (chamber). Exochorion formation and secretion occurs during this stage. The dorsal appendages complete their elongation and the follicle cells die.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005283
comment: Temporal ordering number - 10260.

Axiom
annotated source: oogenesis stage S14
annotated property: definition
annotated target: The last stage of oogenesis. This stage begins when no nurse cell nuclei remain at the anterior of the egg (chamber). Exochorion formation and secretion occurs during this stage. The dorsal appendages complete their elongation and the follicle cells die.
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S14A
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S14
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S13D
definition: Secretion and formation of the outer endochorionic network by throughout the follicle. Crystallization of the innermost chorionic layer of the main body follicle cells.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005284
comment: Temporal ordering number - 10270.

Axiom
annotated source: oogenesis stage S14A
annotated property: definition
annotated target: Secretion and formation of the outer endochorionic network by throughout the follicle. Crystallization of the innermost chorionic layer of the main body follicle cells.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S14B
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S14
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S14A
definition: Secretion of the exochorion begins and ends.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005285
comment: Temporal ordering number - 10280.

Axiom
annotated source: oogenesis stage S14B
annotated property: definition
annotated target: Secretion of the exochorion begins and ends.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0043885

egg stage
type: Class
subclass of: developmental stage
definition: The stage of the Drosophila life-cycle from maturation of an egg to the end of fertilization. At the beginning of this stage, the nucleus is arrested in meiotic metaphase I. The completion of meiosis and the start of protein synthesis are triggered by ovulation. If the female has already mated, fertilization begins during meiosis.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005286
comment: Temporal ordering number - 10290.

Axiom
annotated source: egg stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from maturation of an egg to the end of fertilization. At the beginning of this stage, the nucleus is arrested in meiotic metaphase I. The completion of meiosis and the start of protein synthesis are triggered by ovulation. If the female has already mated, fertilization begins during meiosis.
database_cross_reference: FlyBase:FBrf0064779

unfertilized egg stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: egg stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S14
subclass of: Restriction
  on property: immediately preceded by
  some values from: oogenesis stage S14B
definition: Developmental stage that starts with ovulation, at the end of oogenesis, until the egg is fertilized by a sperm.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005287
comment: Temporal ordering number - 10300.

Axiom
annotated source: unfertilized egg stage
annotated property: definition
annotated target: Developmental stage that starts with ovulation, at the end of oogenesis, until the egg is fertilized by a sperm.
database_cross_reference: FlyBase:FBrf0158848

fertilized egg stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: egg stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: unfertilized egg stage
definition: Developmental stage that starts with sperm entry until the first mitotic division of the zygote.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005288
comment: Temporal ordering number - 10.

Axiom
annotated source: fertilized egg stage
annotated property: definition
annotated target: Developmental stage that starts with sperm entry until the first mitotic division of the zygote.
database_cross_reference: FlyBase:FBrf0229233

embryonic stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: unfertilized egg stage
subclass of: Restriction
  on property: immediately precedes
  some values from: larval stage
subclass of: Restriction
  on property: immediately precedes
  some values from: first instar larval stage
definition: The stage of the Drosophila life-cycle from fertilization to hatching.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005289
comment: Temporal ordering number - 20.

Axiom
annotated source: embryonic stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from fertilization to hatching.
database_cross_reference: FBC:DOS

pre-blastoderm stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: cleavage stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: fertilized egg stage
definition: Embryonic stage 1-3.
has_exact_synonym: pre-blastoderm
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005290
comment: Temporal ordering number - 30.

Axiom
annotated source: pre-blastoderm stage
annotated property: definition
annotated target: Embryonic stage 1-3.
database_cross_reference: FBC:DOS

embryonic stage 1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: fertilized egg stage
definition: The embryonic stage that lasts from the end of fertilization to the end of the second nuclear division. Duration at 25 degrees C: approximately 25 minutes (0-25 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005291
comment: Temporal ordering number - 40.

Axiom
annotated source: embryonic stage 1
annotated property: definition
annotated target: The embryonic stage that lasts from the end of fertilization to the end of the second nuclear division. Duration at 25 degrees C: approximately 25 minutes (0-25 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0064779
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 1
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 1
subclass of: Restriction
  on property: immediately preceded by
  some values from: fertilized egg stage
definition: The first mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005292
comment: Temporal ordering number - 50.

Axiom
annotated source: embryonic cycle 1
annotated property: definition
annotated target: The first mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic stage 2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 1
definition: Nuclear divisions 3-8. The egg cytoplasm contracts producing a clear separation from the vitelline membrane and empty spaces at the anterior and posterior. The cleavage nuclei migrate towards the periphery. Duration at 25 degrees C approximately 40 minutes (25-65 minutes AEL).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005293
comment: Temporal ordering number - 70.

Axiom
annotated source: embryonic stage 2
annotated property: definition
annotated target: Nuclear divisions 3-8. The egg cytoplasm contracts producing a clear separation from the vitelline membrane and empty spaces at the anterior and posterior. The cleavage nuclei migrate towards the periphery. Duration at 25 degrees C approximately 40 minutes (25-65 minutes AEL).
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 2
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 1
definition: The second mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005294
comment: Temporal ordering number - 60.

Axiom
annotated source: embryonic cycle 2
annotated property: definition
annotated target: The second mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 3
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 1
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 2
definition: The third mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005295
comment: Temporal ordering number - 80.

Axiom
annotated source: embryonic cycle 3
annotated property: definition
annotated target: The third mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 4
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 3
definition: The fourth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005296
comment: Temporal ordering number - 90.

Axiom
annotated source: embryonic cycle 4
annotated property: definition
annotated target: The fourth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 5
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 4
definition: The fifth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005297
comment: Temporal ordering number - 100.

Axiom
annotated source: embryonic cycle 5
annotated property: definition
annotated target: The fifth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 6
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 5
definition: The sixth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005298
comment: Temporal ordering number - 110.

Axiom
annotated source: embryonic cycle 6
annotated property: definition
annotated target: The sixth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 7
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 6
definition: The seventh mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005299
comment: Temporal ordering number - 120.

Axiom
annotated source: embryonic cycle 7
annotated property: definition
annotated target: The seventh mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 8
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 7
definition: The eighth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005300
comment: Temporal ordering number - 130.

Axiom
annotated source: embryonic cycle 8
annotated property: definition
annotated target: The eighth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic stage 3
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 8
definition: Nuclear division 9. The cleavage nuclei complete their migration to the periphery. Polar buds form at the posterior pole and divide once. Duration at 25 degrees C: approximately 15 minutes (65-80 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005301
comment: Temporal ordering number - 140.

Axiom
annotated source: embryonic stage 3
annotated property: definition
annotated target: Nuclear division 9. The cleavage nuclei complete their migration to the periphery. Polar buds form at the posterior pole and divide once. Duration at 25 degrees C: approximately 15 minutes (65-80 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 9
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 3
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 8
definition: The ninth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005302
comment: Temporal ordering number - 150.

Axiom
annotated source: embryonic cycle 9
annotated property: definition
annotated target: The ninth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 10
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 4
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 3
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 9
definition: The tenth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005303
comment: Temporal ordering number - 180.

Axiom
annotated source: embryonic cycle 10
annotated property: definition
annotated target: The tenth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

blastoderm stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 3
definition: Embryonic stages 4 and 5.
has_exact_synonym: blastoderm
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005304
comment: Temporal ordering number - 160.

Axiom
annotated source: blastoderm stage
annotated property: definition
annotated target: Embryonic stages 4 and 5.
database_cross_reference: FBC:DOS

obsolete syncytial blastoderm stage
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005305
deprecated: true

embryonic stage 4
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 3
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 9
definition: Nuclear division 10-13. Polar buds divide twice and become tightly grouped at the posterior pole by the end of this stage. Nuclei visible at the rim of the embryo. Stage 4 ends with the beginning of cellularization. Duration at 25 degrees C: approximately 50 minutes (80-130 minutes after egg laying).
has_exact_synonym: syncytial blastoderm
has_exact_synonym: syncytial blastoderm stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005306
comment: Temporal ordering number - 170.

Axiom
annotated source: embryonic stage 4
annotated property: definition
annotated target: Nuclear division 10-13. Polar buds divide twice and become tightly grouped at the posterior pole by the end of this stage. Nuclei visible at the rim of the embryo. Stage 4 ends with the beginning of cellularization. Duration at 25 degrees C: approximately 50 minutes (80-130 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 11
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 4
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 10
definition: The 11th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005307
comment: Temporal ordering number - 185.

Axiom
annotated source: embryonic cycle 11
annotated property: definition
annotated target: The 11th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 12
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 4
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 11
definition: The 12th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005308
comment: Temporal ordering number - 190.

Axiom
annotated source: embryonic cycle 12
annotated property: definition
annotated target: The 12th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 13
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 4
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 12
definition: The 13th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005309
comment: Temporal ordering number - 200.

Axiom
annotated source: embryonic cycle 13
annotated property: definition
annotated target: The 13th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

obsolete cellular blastoderm stage
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005310
deprecated: true

embryonic stage 5
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: cleavage stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 4
definition: Cellularization. Stage 5 begins when cellularization starts. Near the end of this stage the pole cells begin to migrate dorsally and ventral midline cells acquire an irregular, wavy appearance. Stage 5 ends when ventral furrow formation becomes apparent. Duration at 25 degrees: approximately 40 minutes (130-170 minutes after egg laying).
has_exact_synonym: cellular blastoderm
has_exact_synonym: cellular blastoderm stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005311
comment: Temporal ordering number - 210.

Axiom
annotated source: embryonic stage 5
annotated property: definition
annotated target: Cellularization. Stage 5 begins when cellularization starts. Near the end of this stage the pole cells begin to migrate dorsally and ventral midline cells acquire an irregular, wavy appearance. Stage 5 ends when ventral furrow formation becomes apparent. Duration at 25 degrees: approximately 40 minutes (130-170 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 14
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
definition: The 14th mitotic cell cycle of embryogenesis. This is the first round of nuclear division to occur in a cellularized embryo, so this is the first round of cell division. Embryonic cycle 14 mitosis is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
has_exact_synonym: first blastoderm mitosis
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005312
comment: Temporal ordering number - 255. The asynchronous nature of cycle 14 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.

Axiom
annotated source: embryonic cycle 14
annotated property: definition
annotated target: The 14th mitotic cell cycle of embryogenesis. This is the first round of nuclear division to occur in a cellularized embryo, so this is the first round of cell division. Embryonic cycle 14 mitosis is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
database_cross_reference: FlyBase:FBrf0049535
database_cross_reference: FlyBase:FBrf0089570

Axiom
annotated source: embryonic cycle 14
annotated property: has_exact_synonym
annotated target: first blastoderm mitosis
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 14A
type: Class
subclass of: embryonic cycle interphase
subclass of: Restriction
  on property: substage of
  some values from: embryonic cycle 14
definition: The interphase of embryonic cycle 14. This begins at the same time as cellularization and is of variable length depending on cell identity: embryonic cycle 14 M phase (14B) is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
has_exact_synonym: embryonic cycle 14 interphase
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005313
comment: Temporal ordering number - 256.

Axiom
annotated source: embryonic cycle 14A
annotated property: definition
annotated target: The interphase of embryonic cycle 14. This begins at the same time as cellularization and is of variable length depending on cell identity: embryonic cycle 14 M phase (14B) is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
database_cross_reference: FlyBase:FBrf0039741

Axiom
annotated source: embryonic cycle 14A
annotated property: has_exact_synonym
annotated target: embryonic cycle 14 interphase
database_cross_reference: FBC:DOS

embryonic cycle 14B
type: Class
subclass of: embryonic cycle M-phase
subclass of: Restriction
  on property: substage of
  some values from: embryonic cycle 14
definition: The M-phase of embryonic cycle 14. This is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
has_exact_synonym: embryonic cycle 14 M-phase
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005314
comment: Temporal ordering number - 257. Not to be confused with mitotic domain 14B, which is a domain of cells in the dorsal midline of the head that don't undergo a 14th division (Foe, 1989). The asynchronous nature of cycle 14 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.

Axiom
annotated source: embryonic cycle 14B
annotated property: definition
annotated target: The M-phase of embryonic cycle 14. This is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
database_cross_reference: FlyBase:FBrf0039741

Axiom
annotated source: embryonic cycle 14B
annotated property: has_exact_synonym
annotated target: embryonic cycle 14 M-phase
database_cross_reference: FBC:DOS

embryonic cycle 15
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 14
definition: The 15th cell cycle of embryogenesis. Asynchronous.
has_exact_synonym: second blastoderm mitosis
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005315
comment: Temporal ordering number - 285. The asynchronous nature of cycle 15 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.

Axiom
annotated source: embryonic cycle 15
annotated property: definition
annotated target: The 15th cell cycle of embryogenesis. Asynchronous.
database_cross_reference: FlyBase:FBrf0089570

Axiom
annotated source: embryonic cycle 15
annotated property: has_exact_synonym
annotated target: second blastoderm mitosis
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 16
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic cycle 15
definition: The 16th cell cycle division of embryogenesis. Asynchronous.
has_exact_synonym: third blastoderm mitosis
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005316
comment: Temporal ordering number - 295. The asynchronous nature of cycle 16 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.

Axiom
annotated source: embryonic cycle 16
annotated property: definition
annotated target: The 16th cell cycle division of embryogenesis. Asynchronous.
database_cross_reference: FlyBase:FBrf0089570

Axiom
annotated source: embryonic cycle 16
annotated property: has_exact_synonym
annotated target: third blastoderm mitosis
database_cross_reference: FlyBase:FBrf0089570

gastrula stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 5
definition: Stages during which gastrulation occurs. 6-8.
has_exact_synonym: gastrula
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005317
comment: Temporal ordering number - 220.

Axiom
annotated source: gastrula stage
annotated property: definition
annotated target: Stages during which gastrulation occurs. 6-8.
database_cross_reference: FBC:DOS

embryonic stage 6
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: blastoderm stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 5
definition: Stage 6 begins when the ventral furrow becomes apparent, an event which is followed rapidly by the formation of the cephalic furrow. Stage 6 ends when the pole cells have adopted a dorsal (horizontal) position at the posterior. Duration at 25 degrees C: approximately 10 minutes (170-180 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005318
comment: Temporal ordering number - 230.

Axiom
annotated source: embryonic stage 6
annotated property: definition
annotated target: Stage 6 begins when the ventral furrow becomes apparent, an event which is followed rapidly by the formation of the cephalic furrow. Stage 6 ends when the pole cells have adopted a dorsal (horizontal) position at the posterior. Duration at 25 degrees C: approximately 10 minutes (170-180 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 7
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 6
definition: Stage 7 begins when the pole cells have adopted a dorsal (horizontal) position at the posterior. Invagination of the anterior and posterior midgut and hindgut follows. The 'discoid plate' that carries the pole cells forms a pocket. Transverse furrows (dorsal folds) form on the dorsal surface. This stage ends when the anterior wall of the amnioproctodeal invagination starts moving anteriorly and the pole cells are no longer visible externally. Duration at 25 degrees C: approximately 10 minutes (180-190 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005319
comment: Temporal ordering number - 240.

Axiom
annotated source: embryonic stage 7
annotated property: definition
annotated target: Stage 7 begins when the pole cells have adopted a dorsal (horizontal) position at the posterior. Invagination of the anterior and posterior midgut and hindgut follows. The 'discoid plate' that carries the pole cells forms a pocket. Transverse furrows (dorsal folds) form on the dorsal surface. This stage ends when the anterior wall of the amnioproctodeal invagination starts moving anteriorly and the pole cells are no longer visible externally. Duration at 25 degrees C: approximately 10 minutes (180-190 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

obsolete germ band stage
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005320
deprecated: true

extended germ band stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 8
definition: Stages during which the germ band is extended - 9-12.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005321
comment: Temporal ordering number - 260.

Axiom
annotated source: extended germ band stage
annotated property: definition
annotated target: Stages during which the germ band is extended - 9-12.
database_cross_reference: FBC:DOS

embryonic stage 8
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 7
definition: Stage 8 starts with the rapid phase of germ band extension and ends with the beginning of mesodermal segmentation. By the end of this stage germ band extension has progressed to the point where the proctodeal opening is at about 60% egg length and the dorsal folds (transverse furrows) are no longer visible. Duration at 25 degrees C: approximately 30 minutes (190-220 minutes after egg laying).
has_exact_synonym: rapidly extending germ band stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005322
comment: Temporal ordering number - 250.

Axiom
annotated source: embryonic stage 8
annotated property: definition
annotated target: Stage 8 starts with the rapid phase of germ band extension and ends with the beginning of mesodermal segmentation. By the end of this stage germ band extension has progressed to the point where the proctodeal opening is at about 60% egg length and the dorsal folds (transverse furrows) are no longer visible. Duration at 25 degrees C: approximately 30 minutes (190-220 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 9
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: early extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 8
definition: Stage 9 begins when mesodermal segmentation becomes (transiently) visible, and ends with the appearance of the stomodeal invagination slightly ventral to the anterior pole. Duration at 25 degrees C: approximately 40 minutes (220-260 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005323
comment: Temporal ordering number - 280.

Axiom
annotated source: embryonic stage 9
annotated property: definition
annotated target: Stage 9 begins when mesodermal segmentation becomes (transiently) visible, and ends with the appearance of the stomodeal invagination slightly ventral to the anterior pole. Duration at 25 degrees C: approximately 40 minutes (220-260 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 10
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: early extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 9
definition: Stage 10 begins with the appearance of the stomodeal invagination, slightly ventral to the anterior pole. Periodic furrows appear in the embryonic epidermis around the middle of the stage. The germ band continues to extend, reaching its maximum extent of 75% egg length towards the end of the stage. The end of the stage is marked by the beginning of invagination of the tracheal placodes. Duration at 25 degrees : approximately 60 minutes (260-320 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005324
comment: Temporal ordering number - 290.

Axiom
annotated source: embryonic stage 10
annotated property: definition
annotated target: Stage 10 begins with the appearance of the stomodeal invagination, slightly ventral to the anterior pole. Periodic furrows appear in the embryonic epidermis around the middle of the stage. The germ band continues to extend, reaching its maximum extent of 75% egg length towards the end of the stage. The end of the stage is marked by the beginning of invagination of the tracheal placodes. Duration at 25 degrees : approximately 60 minutes (260-320 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 11
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: late extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 10
subclass of: Restriction
  on property: immediately preceded by
  some values from: early extended germ band stage
definition: Stage 11 begins with the invagination of the tracheal placodes. Para-segmental furrow form and segment boundary furrows become deep folds. Within the head, gnathal protuberances become apparent. The end of this stage is signaled by the appearance of a distinct cleft at the posterior pole of the embryo, which becomes detached from the vitelline membrane. This marks the beginning of germ-band retraction. Duration at 25 degrees C: approximately 120 minutes (320-440 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005325
comment: Temporal ordering number - 310.

Axiom
annotated source: embryonic stage 11
annotated property: definition
annotated target: Stage 11 begins with the invagination of the tracheal placodes. Para-segmental furrow form and segment boundary furrows become deep folds. Within the head, gnathal protuberances become apparent. The end of this stage is signaled by the appearance of a distinct cleft at the posterior pole of the embryo, which becomes detached from the vitelline membrane. This marks the beginning of germ-band retraction. Duration at 25 degrees C: approximately 120 minutes (320-440 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

obsolete contracted germ band stage
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005326
deprecated: true

embryonic stage 12
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: late extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 11
definition: Germ band retraction. Stage 12 begins when germ-band retraction starts and ends when this process is complete so that the prospective anal plate occupies the posterior pole. During this stage the posterior and anterior midgut primordia meet and fuse and the tracheal pits fuse to form the tracheal tree. Duration at 25 degrees C: approximately 120 minutes (440-560 minutes after egg laying).
has_exact_synonym: retracting germ band stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005327
comment: Temporal ordering number - 320.

Axiom
annotated source: embryonic stage 12
annotated property: definition
annotated target: Germ band retraction. Stage 12 begins when germ-band retraction starts and ends when this process is complete so that the prospective anal plate occupies the posterior pole. During this stage the posterior and anterior midgut primordia meet and fuse and the tracheal pits fuse to form the tracheal tree. Duration at 25 degrees C: approximately 120 minutes (440-560 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 13
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: late extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 12
definition: Stage 13 begins at the completion of germ-band retraction, when the prospective anal plate occupy the posterior pole. The dorsal ridge becomes apparent externally; the clypeolabrum retracts, leaving a triangular shaped gap at the anterior pole; the labium moves to the ventral midline. This stage ends when head involution begins. Duration at 25 degrees C: Approximately 60 minutes (560-620 minutes after egg laying).
has_exact_synonym: contracted germ band stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005328
comment: Temporal ordering number - 340.

Axiom
annotated source: embryonic stage 13
annotated property: definition
annotated target: Stage 13 begins at the completion of germ-band retraction, when the prospective anal plate occupy the posterior pole. The dorsal ridge becomes apparent externally; the clypeolabrum retracts, leaving a triangular shaped gap at the anterior pole; the labium moves to the ventral midline. This stage ends when head involution begins. Duration at 25 degrees C: Approximately 60 minutes (560-620 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

obsolete head involution stage
type: Class
term replaced by: FBdv:00005330
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005329
deprecated: true

embryonic stage 14
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 13
definition: Stage 14 begins with the initiation of head involution. Closure of the midgut around the yolk and dorsal closure continue. Dorsal closure is 80% complete by the end of this stage. This stage ends with the appearance of the second midgut constriction. Duration at 25 degrees C: approximately 60 minutes (620-680 minutes after egg laying).
has_exact_synonym: head involution stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005330
comment: Temporal ordering number - 350.

Axiom
annotated source: embryonic stage 14
annotated property: definition
annotated target: Stage 14 begins with the initiation of head involution. Closure of the midgut around the yolk and dorsal closure continue. Dorsal closure is 80% complete by the end of this stage. This stage ends with the appearance of the second midgut constriction. Duration at 25 degrees C: approximately 60 minutes (620-680 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

dorsal closure stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: late extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 12
definition: A collective term for stages 13-15.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005331
comment: Temporal ordering number - 330.

Axiom
annotated source: dorsal closure stage
annotated property: definition
annotated target: A collective term for stages 13-15.
database_cross_reference: FBC:DOS

embryonic stage 15
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 14
definition: Stage 15 begins with the appearance of the second midgut constriction. During this stage the 1st and 3rd midgut constrictions form, dorsal closure is completed, and epidermal segmentation is accomplished. This stage ends when the intersegmental grooves can be distinguished at mid-dorsal level. Duration at 25 degrees C: approximately 100 minutes (680-780 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005332
comment: Temporal ordering number - 360.

Axiom
annotated source: embryonic stage 15
annotated property: definition
annotated target: Stage 15 begins with the appearance of the second midgut constriction. During this stage the 1st and 3rd midgut constrictions form, dorsal closure is completed, and epidermal segmentation is accomplished. This stage ends when the intersegmental grooves can be distinguished at mid-dorsal level. Duration at 25 degrees C: approximately 100 minutes (680-780 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

late embryonic stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 15
definition: Embryonic stages 16-17.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005333
comment: Temporal ordering number - 370.

Axiom
annotated source: late embryonic stage
annotated property: definition
annotated target: Embryonic stages 16-17.
database_cross_reference: FBC:DOS

embryonic stage 16
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: late embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 15
definition: Stage 16 begins when the intersegmental grooves can be distinguished at mid-dorsal level, and ends when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. During this stage the ventral cord retracts to about 60% egg length. Duration at 25 degrees C: approximately 180 minutes (780-960 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005334
comment: Temporal ordering number - 380.

Axiom
annotated source: embryonic stage 16
annotated property: definition
annotated target: Stage 16 begins when the intersegmental grooves can be distinguished at mid-dorsal level, and ends when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. During this stage the ventral cord retracts to about 60% egg length. Duration at 25 degrees C: approximately 180 minutes (780-960 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 17
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: late embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 16
definition: Stage 17 begins when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. It lasts until hatching of the embryo (approximately 24 hours after egg laying), during which time much terminal differentiation occurs, the tracheal tree fills with air, so becoming completely visible, and the ventral cord continues to retract. Duration at 25 degrees C: approximately 8 hours (16-24 hours after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005335
comment: Temporal ordering number - 390.

Axiom
annotated source: embryonic stage 17
annotated property: definition
annotated target: Stage 17 begins when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. It lasts until hatching of the embryo (approximately 24 hours after egg laying), during which time much terminal differentiation occurs, the tracheal tree fills with air, so becoming completely visible, and the ventral cord continues to retract. Duration at 25 degrees C: approximately 8 hours (16-24 hours after egg laying).
database_cross_reference: FlyBase:FBrf0089570

larval stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 17(iv)
subclass of: Restriction
  on property: immediately precedes
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately precedes
  some values from: P-stage
definition: The stage of the Drosophila life-cycle from hatching to the beginning of puparium formation.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005336
comment: Temporal ordering number - 400.

Axiom
annotated source: larval stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from hatching to the beginning of puparium formation.
database_cross_reference: FBC:DOS

first instar larval stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage of
  some values from: larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: late embryonic stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 17(iv)
subclass of: Restriction
  on property: immediately precedes
  some values from: second instar larval stage
definition: The first larval instar begins at hatching and ends at the first larval molt. Anterior spiracles are not yet present; posterior spiracles have two openings each. Salivary glands are very small and all cells are uniform in size. Mouth hooks typically have one tooth. Duration at 25 degrees C: approximately 25 hours (24-49 hours after egg laying; 0-25 hours after hatching).
database_cross_reference: UBERON:8000000
has_exact_synonym: L1
has_exact_synonym: first instar larva
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005337
comment: Temporal ordering number - 410.

Axiom
annotated source: first instar larval stage
annotated property: definition
annotated target: The first larval instar begins at hatching and ends at the first larval molt. Anterior spiracles are not yet present; posterior spiracles have two openings each. Salivary glands are very small and all cells are uniform in size. Mouth hooks typically have one tooth. Duration at 25 degrees C: approximately 25 hours (24-49 hours after egg laying; 0-25 hours after hatching).
database_cross_reference: FlyBase:FBrf0007733

second instar larval stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage of
  some values from: larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: first instar larval stage
subclass of: Restriction
  on property: immediately precedes
  some values from: third instar larval stage
definition: The second larval instar begins at the first larval molt and ends at the second larval molt. Larvae are actively feeding and crawling in the food. Distinct anterior spiracles are present as enlargements at the end of the tracheal trunk, but not open to the outside; posterior spiracles have three openings each, and four groups of small unbranched hairs. The salivary glands extend to the first abdominal segment, and have cells that are uniform in size. Mouth hooks typically have two or three teeth. Duration at 25 degrees C: approximately 23 hours (49-72 hours after egg laying; 25-48 hours after hatching).
database_cross_reference: UBERON:8000001
has_exact_synonym: L2
has_exact_synonym: second instar larva
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005338
comment: Temporal ordering number - 420.

Axiom
annotated source: second instar larval stage
annotated property: definition
annotated target: The second larval instar begins at the first larval molt and ends at the second larval molt. Larvae are actively feeding and crawling in the food. Distinct anterior spiracles are present as enlargements at the end of the tracheal trunk, but not open to the outside; posterior spiracles have three openings each, and four groups of small unbranched hairs. The salivary glands extend to the first abdominal segment, and have cells that are uniform in size. Mouth hooks typically have two or three teeth. Duration at 25 degrees C: approximately 23 hours (49-72 hours after egg laying; 25-48 hours after hatching).
database_cross_reference: FlyBase:FBrf0007733

third instar larval stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage of
  some values from: larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: second instar larval stage
subclass of: Restriction
  on property: immediately precedes
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately precedes
  some values from: P-stage
definition: The third larval instar begins at the second larval molt and ends at puparium formation. Anterior spiracles are open to the outside; posterior spiracles have three openings each, and four groups of large branched hairs. The salivary glands extend to the second abdominal segment, with cells larger in the posterior than in the anterior of the gland. Mouth hooks typically have 9-12 teeth. About 24 hours before pupariation (at 25 degree C), larvae stop feeding and climb away from their food. Duration at 25 degrees C: approximately 48 hours (72-120 hours after egg laying; 48-96 hours after hatching).
database_cross_reference: UBERON:8000002
has_exact_synonym: L3
has_obo_namespace: FlyBase_development_CV
has_related_synonym: third instar larva
id: FBdv:00005339
comment: Temporal ordering number - 430.

Axiom
annotated source: third instar larval stage
annotated property: definition
annotated target: The third larval instar begins at the second larval molt and ends at puparium formation. Anterior spiracles are open to the outside; posterior spiracles have three openings each, and four groups of large branched hairs. The salivary glands extend to the second abdominal segment, with cells larger in the posterior than in the anterior of the gland. Mouth hooks typically have 9-12 teeth. About 24 hours before pupariation (at 25 degree C), larvae stop feeding and climb away from their food. Duration at 25 degrees C: approximately 48 hours (72-120 hours after egg laying; 48-96 hours after hatching).
database_cross_reference: FlyBase:FBrf0007733

early third instar larval stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: second instar larval stage
definition: Third instar larva prior to the wandering stage (approximately the first 24 hours of the third instar larval stage under standard conditions at 25'C.).
contributor: http://orcid.org/0000-0002-7073-9172
date: 2008-11-13T11:51:56Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005340
comment: Temporal ordering number - 440.

Axiom
annotated source: early third instar larval stage
annotated property: definition
annotated target: Third instar larva prior to the wandering stage (approximately the first 24 hours of the third instar larval stage under standard conditions at 25'C.).
database_cross_reference: FlyBase:FBrf0049147

wandering third instar larval stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: late third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: early third instar larval stage
definition: Stage of the third larval instar during which the larva wanders out of the food and climbs. Under optimum conditions at 25'C, this occurs approximately 24 hours after the start of the third instar larval stage.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2008-11-13T11:55:46Z
has_broad_synonym: late third instar
has_broad_synonym: post-feeding larva
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005341
comment: Temporal ordering number - 460.

Axiom
annotated source: wandering third instar larval stage
annotated property: definition
annotated target: Stage of the third larval instar during which the larva wanders out of the food and climbs. Under optimum conditions at 25'C, this occurs approximately 24 hours after the start of the third instar larval stage.
database_cross_reference: FlyBase:FBrf0049147

prepupal stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage of
  some values from: P-stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar larval stage L2
subclass of: Restriction
  on property: immediately preceded by
  some values from: late third instar larval stage
subclass of: Restriction
  on property: immediately precedes
  some values from: pupal stage
definition: The prepupal stage begins at puparium formation and ends when larval/pupal apolysis is complete, as indicated by the completion of imaginal head sac eversion and the expulsion of the oral armature of the larva. Duration at 25 degrees C: approximately 12 hours. (120-132.2 hours after egg laying; 0-12.2 hours after puparium formation).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005342
comment: Temporal ordering number - 500.

Axiom
annotated source: prepupal stage
annotated property: definition
annotated target: The prepupal stage begins at puparium formation and ends when larval/pupal apolysis is complete, as indicated by the completion of imaginal head sac eversion and the expulsion of the oral armature of the larva. Duration at 25 degrees C: approximately 12 hours. (120-132.2 hours after egg laying; 0-12.2 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

prepupal stage P1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar larval stage L2
subclass of: Restriction
  on property: immediately preceded by
  some values from: late third instar larval stage
definition: Extends from puparium formation through tanning of the pupal cuticle. Posterior spiracles and ridge between anterior spiracles tan orange. Wriggling stops completely. Puparium becomes brown to the unaided eye. Duration at 25 degrees C: approximately 20 minutes. (120-120.3 hours after egg laying; 0-0.3 hours after puparium formation).
has_exact_synonym: pupal stage P1
has_exact_synonym: puparium formation
has_exact_synonym: white puparium stage
has_narrow_synonym: pupal stage P0
has_narrow_synonym: white prepupa
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005343
comment: Temporal ordering number - 510.

Axiom
annotated source: prepupal stage P1
annotated property: definition
annotated target: Extends from puparium formation through tanning of the pupal cuticle. Posterior spiracles and ridge between anterior spiracles tan orange. Wriggling stops completely. Puparium becomes brown to the unaided eye. Duration at 25 degrees C: approximately 20 minutes. (120-120.3 hours after egg laying; 0-0.3 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P1
annotated property: has_exact_synonym
annotated target: puparium formation
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: prepupal stage P1
annotated property: has_exact_synonym
annotated target: white puparium stage
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: prepupal stage P1
annotated property: has_narrow_synonym
annotated target: pupal stage P0
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: prepupal stage P1
annotated property: has_narrow_synonym
annotated target: white prepupa
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P1
definition: Male gonads become less distinct. Oral armature stops moving permanently. Dorsal medial abdominal contractions stop. Gas bubble becomes visible within abdomen. Duration at 25 degrees C: approximately 100 minutes. (120.3-122 hours after egg laying; 0.3-2 hours after puparium formation).
has_exact_synonym: brown puparium stage
has_exact_synonym: pupal stage P2
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005344
comment: Temporal ordering number - 520.

Axiom
annotated source: prepupal stage P2
annotated property: definition
annotated target: Male gonads become less distinct. Oral armature stops moving permanently. Dorsal medial abdominal contractions stop. Gas bubble becomes visible within abdomen. Duration at 25 degrees C: approximately 100 minutes. (120.3-122 hours after egg laying; 0.3-2 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P2
annotated property: has_exact_synonym
annotated target: brown puparium stage
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P3
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P2
definition: Ridge of the operculum becomes distinct. Puparium begins to separate from underlying epidermis. Becomes positively buoyant. Duration at 25 degrees C: approximately 4 hours, 45 minutes. (122-126.75 hours after egg laying; 2-6.75 hours after puparium formation).
has_exact_synonym: bubble prepupa stage
has_exact_synonym: pupal stage P3
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005345
comment: Temporal ordering number - 530.

Axiom
annotated source: prepupal stage P3
annotated property: definition
annotated target: Ridge of the operculum becomes distinct. Puparium begins to separate from underlying epidermis. Becomes positively buoyant. Duration at 25 degrees C: approximately 4 hours, 45 minutes. (122-126.75 hours after egg laying; 2-6.75 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P3
annotated property: has_exact_synonym
annotated target: bubble prepupa stage
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P4
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P3
definition: Prepupal stage P4 begins as the lateral trunk trachea become obscured and ends when the imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 5 hours, 30 minutes. (126.75-132.2 hours after egg laying; 6.75-12.2 hours after puparium formation).
has_exact_synonym: cryptocephalic pupa
has_exact_synonym: pupal stage P4
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005346
comment: Temporal ordering number - 540.

Axiom
annotated source: prepupal stage P4
annotated property: definition
annotated target: Prepupal stage P4 begins as the lateral trunk trachea become obscured and ends when the imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 5 hours, 30 minutes. (126.75-132.2 hours after egg laying; 6.75-12.2 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P4
annotated property: has_exact_synonym
annotated target: cryptocephalic pupa
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P4(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: prepupal stage P4
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P3
definition: Lateral trunk tracheae become obscured. Dorsal medial abdominal contractions occur. Everted leg and wing discs become visible. Bubble appears in posterior of puparium, displacing the pupa anteriorly; abdominal bubble disappears. Duration at 25 degrees C: approximately 5 hours, 15 minutes. (126.75-132 hours after egg laying; 6.75-12 hours after puparium formation).
has_exact_synonym: buoyant stage
has_exact_synonym: pupal stage P4(i)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005347
comment: Temporal ordering number - 550.

Axiom
annotated source: prepupal stage P4(i)
annotated property: definition
annotated target: Lateral trunk tracheae become obscured. Dorsal medial abdominal contractions occur. Everted leg and wing discs become visible. Bubble appears in posterior of puparium, displacing the pupa anteriorly; abdominal bubble disappears. Duration at 25 degrees C: approximately 5 hours, 15 minutes. (126.75-132 hours after egg laying; 6.75-12 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P4(i)
annotated property: has_exact_synonym
annotated target: buoyant stage
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P4(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: prepupal stage P4
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P4(i)
definition: Bubble is displaced to anterior end of the puparium, and pupa withdraws to the posterior end. Imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 12 minutes. (132-132.2 hours after egg laying; 12-12.2 hours after puparium formation).
has_exact_synonym: moving bubble stage
has_exact_synonym: pupal stage P4(ii)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005348
comment: Temporal ordering number - 560.

Axiom
annotated source: prepupal stage P4(ii)
annotated property: definition
annotated target: Bubble is displaced to anterior end of the puparium, and pupa withdraws to the posterior end. Imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 12 minutes. (132-132.2 hours after egg laying; 12-12.2 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P4(ii)
annotated property: has_exact_synonym
annotated target: moving bubble stage
database_cross_reference: FlyBase:FBrf0036849

pupal stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage of
  some values from: P-stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately precedes
  some values from: pharate adult stage
definition: The pupal stage starts once larval/pupal apolysis is complete as indicated by the expulsion of the larval armature. Early in this stage, the legs and wings reach full extension along the abdomen. The stage ends when the pupal cuticle separates from the underlying epidermis (pupal/adult apolysis), and the eye cup becomes yellow at its periphery. Duration at 25 degrees C: approximately 32 hours. (132.2-164.3 hours after egg laying; 12.2-44.3 hours after puparium formation).
has_exact_synonym: phanerocephalic pupa
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005349
comment: Temporal ordering number - 570. DISAMBIGUATION: In Drosophila lab vernacular, the term 'pupal stage' is often used to refer to the entire period from formation of the puparium to eclosion. However, this does not correspond to the standard usage of 'pupal stage' for Cyclorrhaphous flies (for discussion see: FBrf0087128). Briefly: formation of the puparium (hardening of the larval cuticle) marks the beginning of the pre-pupal stage. The pupal stage begins following pupal/larval apolysis - detachment of the larval epidermis from the puparium. In Drosophila, the outward sign of the completion of apolysis is the eversion of the head and expulsion of the larval mouthparts (FBrf0036849). We use P-stage to refer to the stage from pupariation to eclosion, and restrict pupal stage to its standard usage.

Axiom
annotated source: pupal stage
annotated property: definition
annotated target: The pupal stage starts once larval/pupal apolysis is complete as indicated by the expulsion of the larval armature. Early in this stage, the legs and wings reach full extension along the abdomen. The stage ends when the pupal cuticle separates from the underlying epidermis (pupal/adult apolysis), and the eye cup becomes yellow at its periphery. Duration at 25 degrees C: approximately 32 hours. (132.2-164.3 hours after egg laying; 12.2-44.3 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage
annotated property: has_exact_synonym
annotated target: phanerocephalic pupa
database_cross_reference: FlyBase:FBrf0036849

pupal stage P5
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P4
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P4(ii)
definition: Pupal stage P5 starts when the legs and wings reach full extension along the abdomen and ends as the Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 6 hours, 30 minutes. (132.2-138.7 hours after egg laying; 12.2-18.7 hours after puparium formation).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005350
comment: Temporal ordering number - 580.

Axiom
annotated source: pupal stage P5
annotated property: definition
annotated target: Pupal stage P5 starts when the legs and wings reach full extension along the abdomen and ends as the Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 6 hours, 30 minutes. (132.2-138.7 hours after egg laying; 12.2-18.7 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

pupal stage P5(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pupal stage P5
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P4
subclass of: Restriction
  on property: immediately preceded by
  some values from: prepupal stage P4(ii)
definition: Legs and wings reach full extension along abdomen. Enlarged initial segments of anterior pair Malpighian tubules move from thorax into abdomen. Translucent patch that lacks adhering fat body cells becomes discernible in the middle of the eye region. Pair of white Malpighian tubules becomes visible dorsally in the abdomen. Duration at 25 degrees C: approximately 66 minutes. (132.2-133.3 hours after egg laying; 12.2-13.3 hours after puparium formation).
has_exact_synonym: Malpighian tubules migrating
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005351
comment: Temporal ordering number - 590.

Axiom
annotated source: pupal stage P5(i)
annotated property: definition
annotated target: Legs and wings reach full extension along abdomen. Enlarged initial segments of anterior pair Malpighian tubules move from thorax into abdomen. Translucent patch that lacks adhering fat body cells becomes discernible in the middle of the eye region. Pair of white Malpighian tubules becomes visible dorsally in the abdomen. Duration at 25 degrees C: approximately 66 minutes. (132.2-133.3 hours after egg laying; 12.2-13.3 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage P5(i)
annotated property: has_exact_synonym
annotated target: Malpighian tubules migrating
database_cross_reference: FlyBase:FBrf0036849

pupal stage P5(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pupal stage P5
subclass of: Restriction
  on property: immediately preceded by
  some values from: pupal stage P5(i)
definition: Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 5 hours, 25 minutes. (133.3-138.7 hours after egg laying; 13.3-18.7 hours after puparium formation).
has_exact_synonym: white Malpighian tubules stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005352
comment: Temporal ordering number - 600.

Axiom
annotated source: pupal stage P5(ii)
annotated property: definition
annotated target: Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 5 hours, 25 minutes. (133.3-138.7 hours after egg laying; 13.3-18.7 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage P5(ii)
annotated property: has_exact_synonym
annotated target: white Malpighian tubules stage
database_cross_reference: FlyBase:FBrf0036849

pupal stage P6
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pupal stage P5
subclass of: Restriction
  on property: immediately preceded by
  some values from: pupal stage P5(ii)
definition: Dark green 'yellow body' appears between the anterior ends of the two Malpighian tubule segments, mid-dorsally at the anterior of the abdomen. Duration at 25 degrees C: approximately 13 hours, 45 minutes. (138.7-152.4 hours after egg laying; 18.7-32.4 hours after puparium formation).
has_exact_synonym: green Malpighian tubules stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005353
comment: Temporal ordering number - 610.

Axiom
annotated source: pupal stage P6
annotated property: definition
annotated target: Dark green 'yellow body' appears between the anterior ends of the two Malpighian tubule segments, mid-dorsally at the anterior of the abdomen. Duration at 25 degrees C: approximately 13 hours, 45 minutes. (138.7-152.4 hours after egg laying; 18.7-32.4 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage P6
annotated property: has_exact_synonym
annotated target: green Malpighian tubules stage
database_cross_reference: FlyBase:FBrf0036849

pupal stage P7
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pupal stage P6
definition: The 'yellow body' moves back between the Malpighian tubules. The transparent pupal cuticle separates from the underlying epidermis. Eye cup becomes yellow at its perimeter. Duration at 25 degrees C: approximately 12 hours. (152.4-164.3 hours after egg laying; 32.4-44.3 hours after puparium formation).
has_exact_synonym: yellow body stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005354
comment: Temporal ordering number - 620.

Axiom
annotated source: pupal stage P7
annotated property: definition
annotated target: The 'yellow body' moves back between the Malpighian tubules. The transparent pupal cuticle separates from the underlying epidermis. Eye cup becomes yellow at its perimeter. Duration at 25 degrees C: approximately 12 hours. (152.4-164.3 hours after egg laying; 32.4-44.3 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage P7
annotated property: has_exact_synonym
annotated target: yellow body stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P8
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pupal stage P7
definition: Pale yellow pigmentation spreads inwards across the eye. Eye color becomes bright yellow, then changes to amber. Duration at 25 degrees C: approximately 12 hours 20 minutes. (164.3-176.6 hours after egg laying; 44.3-56.6 hours after puparium formation).
has_exact_synonym: pupal stage P8
has_exact_synonym: yellow-eyed stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005355
comment: Temporal ordering number - 630.

Axiom
annotated source: pharate adult stage P8
annotated property: definition
annotated target: Pale yellow pigmentation spreads inwards across the eye. Eye color becomes bright yellow, then changes to amber. Duration at 25 degrees C: approximately 12 hours 20 minutes. (164.3-176.6 hours after egg laying; 44.3-56.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P8
annotated property: has_exact_synonym
annotated target: yellow-eyed stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P9
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P8
definition: Eye color darkens to deep amber, then becomes pale pink. Duration at 25 degrees C: approximately 18 hours. (176.6-194.5 hours after egg laying; 56.6-74.5 hours after puparium formation).
has_exact_synonym: amber-eyed stage
has_exact_synonym: pupal stage P9
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005356
comment: Temporal ordering number - 640.

Axiom
annotated source: pharate adult stage P9
annotated property: definition
annotated target: Eye color darkens to deep amber, then becomes pale pink. Duration at 25 degrees C: approximately 18 hours. (176.6-194.5 hours after egg laying; 56.6-74.5 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P9
annotated property: has_exact_synonym
annotated target: amber-eyed stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P10
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P9
definition: Eyes become bright red. Orbital and ocellar bristles and vibrissae darken. Duration at 25 degrees C: approximately 6 minutes. (194.5-194.6 hours after egg laying; 74.5-74.6 hours after puparium formation).
has_exact_synonym: pupal stage P10
has_exact_synonym: red-eye bald stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005357
comment: Temporal ordering number - 650.

Axiom
annotated source: pharate adult stage P10
annotated property: definition
annotated target: Eyes become bright red. Orbital and ocellar bristles and vibrissae darken. Duration at 25 degrees C: approximately 6 minutes. (194.5-194.6 hours after egg laying; 74.5-74.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P10
annotated property: has_exact_synonym
annotated target: red-eye bald stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P11
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P10
definition: Thoracic bristles become visible, and the tips of the wings turn grey. Duration at 25 degrees C: approximately 2 hours. (194.6-196.6 hours after egg laying; 74.6-76.6 hours after puparium formation).
has_exact_synonym: pupal stage P11
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005358
comment: Temporal ordering number - 660.

Axiom
annotated source: pharate adult stage P11
annotated property: definition
annotated target: Thoracic bristles become visible, and the tips of the wings turn grey. Duration at 25 degrees C: approximately 2 hours. (194.6-196.6 hours after egg laying; 74.6-76.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

pharate adult stage P11(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage P11
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P10
definition: Dorsal thoracic microchaetes and macrochaetes become visible. Duration at 25 degrees C: approximately 80 minutes (194.6-195.5 hours after egg laying; 74.6-75.9 hours after puparium formation).
has_exact_synonym: head bristles stage
has_exact_synonym: pupal stage P11(i)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005359
comment: Temporal ordering number - 670.

Axiom
annotated source: pharate adult stage P11(i)
annotated property: definition
annotated target: Dorsal thoracic microchaetes and macrochaetes become visible. Duration at 25 degrees C: approximately 80 minutes (194.6-195.5 hours after egg laying; 74.6-75.9 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P11(i)
annotated property: has_exact_synonym
annotated target: head bristles stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P11(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage P11
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P11(i)
definition: Tips of folded wings become grey. Duration at 25 degrees C: approximately 45 minutes (195.5-196.6 hours after egg laying; 75.9-76.6 hours after puparium formation).
has_exact_synonym: pupal stage P11(ii)
has_exact_synonym: thoracic bristles stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005360
comment: Temporal ordering number - 680.

Axiom
annotated source: pharate adult stage P11(ii)
annotated property: definition
annotated target: Tips of folded wings become grey. Duration at 25 degrees C: approximately 45 minutes (195.5-196.6 hours after egg laying; 75.9-76.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P11(ii)
annotated property: has_exact_synonym
annotated target: thoracic bristles stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P12
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P11
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P11(ii)
definition: Pharate adult stage P12 begins as the abdominal tergite bristles become visible, and ends as the wings darken to black. Duration at 25 degrees C: approximately 2 hours. (196.6-198.6 hours after egg laying; 76.6-78.6 hours after puparium formation).
has_exact_synonym: pupal stage P12
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005361
comment: Temporal ordering number - 690.

Axiom
annotated source: pharate adult stage P12
annotated property: definition
annotated target: Pharate adult stage P12 begins as the abdominal tergite bristles become visible, and ends as the wings darken to black. Duration at 25 degrees C: approximately 2 hours. (196.6-198.6 hours after egg laying; 76.6-78.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

pharate adult stage P12(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage P12
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P11
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P11(ii)
definition: Bristles of the abdominal tergites become visible, and the wings become grey. Duration at 25 degrees C: approximately 55 minutes. (196.6-197.5 hours after egg laying; 76.6-77.5 hours after puparium formation).
has_exact_synonym: pupal stage P12(i)
has_exact_synonym: wing tips grey stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005362
comment: Temporal ordering number - 700.

Axiom
annotated source: pharate adult stage P12(i)
annotated property: definition
annotated target: Bristles of the abdominal tergites become visible, and the wings become grey. Duration at 25 degrees C: approximately 55 minutes. (196.6-197.5 hours after egg laying; 76.6-77.5 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P12(i)
annotated property: has_exact_synonym
annotated target: wing tips grey stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P12(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage P12
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P12(i)
definition: Sex combs darken in males. Wings darken to black. Duration at 25 degrees C: approximately 65 minutes. (197.5-198.6 hours after egg laying; 77.5-78.6 hours after puparium formation).
has_exact_synonym: pupal stage P12(ii)
has_exact_synonym: wings grey stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005363
comment: Temporal ordering number - 710.

Axiom
annotated source: pharate adult stage P12(ii)
annotated property: definition
annotated target: Sex combs darken in males. Wings darken to black. Duration at 25 degrees C: approximately 65 minutes. (197.5-198.6 hours after egg laying; 77.5-78.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P12(ii)
annotated property: has_exact_synonym
annotated target: wings grey stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P13
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P12
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P12(ii)
definition: Tarsal bristles darken and claws become black. Duration at 25 degrees C: approximately 3 hours, 20 minutes. (198.6-201.9 hours after egg laying; 78.6-81.9 hours after puparium formation).
has_exact_synonym: pupal stage P13
has_exact_synonym: wings black stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005364
comment: Temporal ordering number - 720.

Axiom
annotated source: pharate adult stage P13
annotated property: definition
annotated target: Tarsal bristles darken and claws become black. Duration at 25 degrees C: approximately 3 hours, 20 minutes. (198.6-201.9 hours after egg laying; 78.6-81.9 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P13
annotated property: has_exact_synonym
annotated target: wings black stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P14
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P13
definition: The meconium appears dorsally at the posterior tip of the abdomen. Duration at 25 degrees C: approximately 9 hours, 30 minutes (201.9-211.5 hours after egg laying; 81.9-91.5 hours after puparium formation).
has_exact_synonym: mature bristles stage
has_exact_synonym: pupal stage P14
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005365
comment: Temporal ordering number - 730.

Axiom
annotated source: pharate adult stage P14
annotated property: definition
annotated target: The meconium appears dorsally at the posterior tip of the abdomen. Duration at 25 degrees C: approximately 9 hours, 30 minutes (201.9-211.5 hours after egg laying; 81.9-91.5 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P14
annotated property: has_exact_synonym
annotated target: mature bristles stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P15
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P14
definition: Pharate adult stage P15 begins with the tanning of the tergites and ends with eclosion. Duration at 25 degrees C: approximately 8 hours, 30 minutes. (211.5-220 hours after egg laying; 91.5-100 hours after puparium formation).
has_exact_synonym: pupal stage P15
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005366
comment: Temporal ordering number - 740.

Axiom
annotated source: pharate adult stage P15
annotated property: definition
annotated target: Pharate adult stage P15 begins with the tanning of the tergites and ends with eclosion. Duration at 25 degrees C: approximately 8 hours, 30 minutes. (211.5-220 hours after egg laying; 91.5-100 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

pharate adult stage P15(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage P15
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P14
definition: Tanning of the tergites obscures the Malpighian tubules and the 'yellow body'. Legs begin to twitch; fly is able to walk if puparium is removed prematurely. Ptilinum expands by hydrostatic pressure, opening the operculum. Duration at 25 degrees C: approximately 8 hours, 6 minutes. (211.5-219.6 hours after egg laying; 91.5-99.6 hours after puparium formation).
has_exact_synonym: meconium stage
has_exact_synonym: pupal stage P15(i)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005367
comment: Temporal ordering number - 750.

Axiom
annotated source: pharate adult stage P15(i)
annotated property: definition
annotated target: Tanning of the tergites obscures the Malpighian tubules and the 'yellow body'. Legs begin to twitch; fly is able to walk if puparium is removed prematurely. Ptilinum expands by hydrostatic pressure, opening the operculum. Duration at 25 degrees C: approximately 8 hours, 6 minutes. (211.5-219.6 hours after egg laying; 91.5-99.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P15(i)
annotated property: has_exact_synonym
annotated target: meconium stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P15(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: pharate adult stage P15
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P15(i)
definition: Stage which starts when the operculum opens and ends when eclosion is completed. Duration at 25 degrees C: approximately 24 minutes. (219.6-220 hours after egg laying; 99.6-100 hours after puparium formation).
has_exact_synonym: eclosion stage
has_exact_synonym: pupal stage P15(ii)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005368
comment: Temporal ordering number - 760.

Axiom
annotated source: pharate adult stage P15(ii)
annotated property: definition
annotated target: Stage which starts when the operculum opens and ends when eclosion is completed. Duration at 25 degrees C: approximately 24 minutes. (219.6-220 hours after egg laying; 99.6-100 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P15(ii)
annotated property: has_exact_synonym
annotated target: eclosion stage
database_cross_reference: FlyBase:FBrf0036849

adult stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P15
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P15(ii)
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: P-stage
definition: The stage of the Drosophila life-cycle from eclosion to death.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005369
comment: Temporal ordering number - 770.

Axiom
annotated source: adult stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from eclosion to death.
database_cross_reference: FBC:DOS

adult stage A1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: immature adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P15(ii)
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: P-stage
subclass of: Restriction
  on property: immediately precedes
  some values from: adult stage A2
definition: Newly eclosed adult stage. Animal free of pupal case. Runs rapidly to find site for wing expansion. Wings are folded back and black against a very pale abdomen.
has_alternative_id: FBdv:00005373
has_obo_namespace: FlyBase_development_CV
has_related_synonym: adult stage I
id: FBdv:00005370
comment: Temporal ordering number - 785. The time at which eclosed flies settle down for wing expansion can vary greatly. If they fail to find a suitable site then expansion can be delayed by several hours.

Axiom
annotated source: adult stage A1
annotated property: definition
annotated target: Newly eclosed adult stage. Animal free of pupal case. Runs rapidly to find site for wing expansion. Wings are folded back and black against a very pale abdomen.
database_cross_reference: FlyBase:FBrf0049147

adult stage A2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: immature adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: adult stage A1
subclass of: Restriction
  on property: immediately precedes
  some values from: adult stage A3
definition: Stage, shortly after eclosion, during which the wings expand. During wing expansion, the abdomen pulsates and the hind legs stroke the wings vigorously for several minutes at a time. The stage ends when the wings are folded down over the abdomen, which has become broader and shorter, and the wing cuticle has lost its folds. The stage lasts around 15 minutes at 25'C.
has_alternative_id: FBdv:00005374
has_obo_namespace: FlyBase_development_CV
has_related_synonym: adult stage II
id: FBdv:00005371
comment: Temporal ordering number - 790.

Axiom
annotated source: adult stage A2
annotated property: definition
annotated target: Stage, shortly after eclosion, during which the wings expand. During wing expansion, the abdomen pulsates and the hind legs stroke the wings vigorously for several minutes at a time. The stage ends when the wings are folded down over the abdomen, which has become broader and shorter, and the wing cuticle has lost its folds. The stage lasts around 15 minutes at 25'C.
database_cross_reference: FlyBase:FBrf0049147

FBdv_00005373
type: Class
IAO_0000231: IAO_0000227
term replaced by: adult stage A1
deprecated: true

FBdv_00005374
type: Class
IAO_0000231: IAO_0000227
term replaced by: adult stage A2
deprecated: true

FBdv_00005375
type: Class
IAO_0000231: IAO_0000227
term replaced by: adult stage A3
deprecated: true

obsolete gamete
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005412
comment: This should be considered as a type of cell rather than as a stage. Please use FBbt:00005412.
deprecated: true

pharate adult stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage of
  some values from: P-stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pupal stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pupal stage P7
subclass of: Restriction
  on property: immediately precedes
  some values from: adult stage
subclass of: Restriction
  on property: immediately precedes
  some values from: adult stage A1
subclass of: Restriction
  on property: immediately precedes
  some values from: immature adult stage
definition: The developing adult after pupal-adult apolysis, i.e.- from stage P8 (when yellow eye color first becomes visible through the pupal case), to eclosion. Duration at 25 degrees C: approximately 55.7 hours (164.3-220 hours after egg laying; 44.3-100 hours after puparium formation).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00006011
comment: Temporal ordering number - 625.

Axiom
annotated source: pharate adult stage
annotated property: definition
annotated target: The developing adult after pupal-adult apolysis, i.e.- from stage P8 (when yellow eye color first becomes visible through the pupal case), to eclosion. Duration at 25 degrees C: approximately 55.7 hours (164.3-220 hours after egg laying; 44.3-100 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355
database_cross_reference: FlyBase:FBrf0049147

adult stage A3
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: immature adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: adult stage A2
subclass of: Restriction
  on property: immediately precedes
  some values from: mature adult stage
definition: Adult stage immediately after wing expansion, during which tanning of the cuticle is completed. This stage lasts approximately 45 minutes at 25'C.
has_alternative_id: FBdv:00005375
has_obo_namespace: FlyBase_development_CV
has_related_synonym: adult stage III
id: FBdv:00006012
comment: Temporal ordering number - 800.

Axiom
annotated source: adult stage A3
annotated property: definition
annotated target: Adult stage immediately after wing expansion, during which tanning of the cuticle is completed. This stage lasts approximately 45 minutes at 25'C.
database_cross_reference: FlyBase:FBrf0049147

spermatogenesis
type: Class
subclass of: developmental process
definition: The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoon.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2008-06-05T04:51:08Z
database_cross_reference: GO:0007283
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007000
comment: Temporal ordering number - 20000.

Axiom
annotated source: spermatogenesis
annotated property: definition
annotated target: The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoon.
database_cross_reference: GO:0007283

P-stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar larval stage L2
subclass of: Restriction
  on property: immediately preceded by
  some values from: late third instar larval stage
subclass of: Restriction
  on property: immediately precedes
  some values from: adult stage
subclass of: Restriction
  on property: immediately precedes
  some values from: adult stage A1
subclass of: Restriction
  on property: immediately precedes
  some values from: immature adult stage
definition: The stage of the Drosophila life-cycle from the formation of the puparium (beginning of the prepupal stage) to eclosion.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2008-06-05T04:51:40Z
has_broad_synonym: metamorphosis
has_obo_namespace: FlyBase_development_CV
has_related_synonym: pupal stage
id: FBdv:00007001
comment: Temporal ordering number - 490. DISAMBIGUATION: In Drosophila lab vernacular, the term 'pupal stage' is often used to refer to the entire period from formation of the puparium to eclosion. However, this does not correspond to the standard usage of 'pupal stage' for cyclorrhaphous flies (for discussion see: FBrf0087128). Briefly: formation of the puparium (hardening of the larval cuticle) marks the beginning of the pre-pupal stage. The pupal stage begins following pupal/larval apolysis - detachment of the larval epidermis from the puparium. In Drosophila, the outward sign of the completion of apolysis is the eversion of the head an expulsion of the larval mouthparts (FBrf0036849). We use P-stage to refer to the stage from pupariation to eclosion, and restrict pupal stage to its standard usage.

Axiom
annotated source: P-stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from the formation of the puparium (beginning of the prepupal stage) to eclosion.
database_cross_reference: FBC:DOS

oogenesis stage S11a
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S11
definition: Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins and ends when the dorsal appendages begin to form.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007002
comment: Temporal ordering number - 10140.

Axiom
annotated source: oogenesis stage S11a
annotated property: definition
annotated target: Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins and ends when the dorsal appendages begin to form.
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S11b
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S11
definition: Oogenesis stage that begins when endochorion begins to form at the anterior pole, a process which includes the beginning of formation of the dorsal appendages. During this stage, the follicle cells secrete membranous vesicles that form irregular extracellular plaques. This stage ends when dying nurse cells form an anterior cap to the oocyte.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007003
comment: Temporal ordering number - 10150.

Axiom
annotated source: oogenesis stage S11b
annotated property: definition
annotated target: Oogenesis stage that begins when endochorion begins to form at the anterior pole, a process which includes the beginning of formation of the dorsal appendages. During this stage, the follicle cells secrete membranous vesicles that form irregular extracellular plaques. This stage ends when dying nurse cells form an anterior cap to the oocyte.
database_cross_reference: FlyBase:FBrf0043885

third instar larval stage L1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: late third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: wandering third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar - cleared gut stage
definition: Stage which begins when wandering third instar larva stops crawling. The larva everts its anterior spiracles during this stage.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007004
comment: Temporal ordering number - 470.

Axiom
annotated source: third instar larval stage L1
annotated property: definition
annotated target: Stage which begins when wandering third instar larva stops crawling. The larva everts its anterior spiracles during this stage.
database_cross_reference: FlyBase:FBrf0036849

third instar larval stage L2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: late third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar larval stage L1
definition: The anterior spiracles are fully everted, with 7-9 finger-like projections. The body shortens, withdrawing three apparent abdominal segments and the larva sticks to its substrate.
has_exact_synonym: spiracles everted larva
has_obo_namespace: FlyBase_development_CV
has_related_synonym: white prepupa
id: FBdv:00007005
comment: Temporal ordering number - 480.

Axiom
annotated source: third instar larval stage L2
annotated property: definition
annotated target: The anterior spiracles are fully everted, with 7-9 finger-like projections. The body shortens, withdrawing three apparent abdominal segments and the larva sticks to its substrate.
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: third instar larval stage L2
annotated property: has_exact_synonym
annotated target: spiracles everted larva
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: third instar larval stage L2
annotated property: has_related_synonym
annotated target: white prepupa
database_cross_reference: FlyBase:FBrf0036849

oogenesis stage S13E
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: oogenesis stage S13
definition: Oogenesis stage during which the number of nurse cell nuclei at the anterior of the oocyte reduce from 4 to zero. The oocyte chromosomes reach full metaphase I during this stage, at which point meiosis is arrested (until fertilization).
contributor: http://orcid.org/0000-0002-7073-9172
date: 2008-11-13T06:27:57Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007006
comment: Temporal ordering number - 10250.

Axiom
annotated source: oogenesis stage S13E
annotated property: definition
annotated target: Oogenesis stage during which the number of nurse cell nuclei at the anterior of the oocyte reduce from 4 to zero. The oocyte chromosomes reach full metaphase I during this stage, at which point meiosis is arrested (until fertilization).
database_cross_reference: FlyBase:FBrf0029744

late third instar larval stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: early third instar larval stage
definition: Third instar larva from the beginning of wandering to the beginning of puparium formation.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2008-12-11T01:19:53Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007007
comment: Temporal ordering number - 450.

Axiom
annotated source: late third instar larval stage
annotated property: definition
annotated target: Third instar larva from the beginning of wandering to the beginning of puparium formation.
database_cross_reference: FBC:DOS

obsolete occurrent
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007008
deprecated: true

developmental process
type: Class
subclass of: biological process
definition: A biological process whose specific outcome is the progression of an integrated living unit (an anatomical structure or an entire organism) over time from an initial condition to a later condition.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2009-10-01T05:56:42Z
database_cross_reference: GO:0032502
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007009

Axiom
annotated source: developmental process
annotated property: definition
annotated target: A biological process whose specific outcome is the progression of an integrated living unit (an anatomical structure or an entire organism) over time from an initial condition to a later condition.
database_cross_reference: GO:0032502

FBdv_00007010
type: Class
IAO_0000231: IAO_0000227
term replaced by: developmental stage
deprecated: true

embryonic cycle
type: Class
subclass of: biological process
subclass of: mitotic cell cycle, embryonic
definition: A cycle of nuclear division during the embryogenesis of Drosophila melanogaster. The first 13 cycles are synchronous throughout the embryo and occur their timing relative to other developmental processes is invariant. Later nuclear division cycles are asynchronous across the embryo although may be more locally synchronized.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2009-10-01T05:57:41Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007011

Axiom
annotated source: embryonic cycle
annotated property: definition
annotated target: A cycle of nuclear division during the embryogenesis of Drosophila melanogaster. The first 13 cycles are synchronous throughout the embryo and occur their timing relative to other developmental processes is invariant. Later nuclear division cycles are asynchronous across the embryo although may be more locally synchronized.
database_cross_reference: FlyBase:FBrf0049535
database_cross_reference: FlyBase:FBrf0089570

life stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: Drosophila life
definition: A temporal subdivision of a Drosophila life, delimited by major transitions in the circumstances of the organism, such as: fertilization; hatching; pupal ecdysis; eclosion.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2009-10-01T05:59:22Z
has_exact_synonym: life cycle stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007012

Axiom
annotated source: life stage
annotated property: definition
annotated target: A temporal subdivision of a Drosophila life, delimited by major transitions in the circumstances of the organism, such as: fertilization; hatching; pupal ecdysis; eclosion.
database_cross_reference: FBC:DOS

age
type: Class
subclass of: occurrent
definition: Temporal subdivision of life based on time elapsed since some key developmental transition, such as fertilization, hatching or eclosion.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2010-09-29T12:25:36Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007013

Axiom
annotated source: age
annotated property: definition
annotated target: Temporal subdivision of life based on time elapsed since some key developmental transition, such as fertilization, hatching or eclosion.
database_cross_reference: FBC:DOS

adult age in days
type: Class
subclass of: age
definition: Temporal subdivision of adulthood in days post-eclosion.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2010-09-29T12:28:05Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007014

Axiom
annotated source: adult age in days
annotated property: definition
annotated target: Temporal subdivision of adulthood in days post-eclosion.
database_cross_reference: FBC:DOS

embryonic stage 17(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 16
definition: The first two hours of embryonic stage 17 at 25'C. (Approximately 16-18 hours at 25'C after egg laying).
contributor: http://orcid.org/0000-0002-7073-9172
date: 2011-04-26T11:57:15Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007015
comment: Temporal ordering number - 391. Should not be used to stage embryos whose development is at temperatures other than 25'C.

Axiom
annotated source: embryonic stage 17(i)
annotated property: definition
annotated target: The first two hours of embryonic stage 17 at 25'C. (Approximately 16-18 hours at 25'C after egg laying).
database_cross_reference: FBC:DOS

embryonic stage 17(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 17(i)
definition: Hours 2-4 of embryonic stage 17 at 25'C. (Approximately 18-20 hours at 25'C after egg laying).
contributor: http://orcid.org/0000-0002-7073-9172
date: 2011-04-26T12:00:15Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007016
comment: Temporal ordering number - 392. Should not be used to stage embryos whose development is at temperatures other than 25'C.

Axiom
annotated source: embryonic stage 17(ii)
annotated property: definition
annotated target: Hours 2-4 of embryonic stage 17 at 25'C. (Approximately 18-20 hours at 25'C after egg laying).
database_cross_reference: FBC:DOS

embryonic stage 17(iii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 17(ii)
definition: Hours 4-6 of embryonic stage 17 at 25'C. (Approximately 20-22 hours at 25'C after egg laying).
contributor: http://orcid.org/0000-0002-7073-9172
date: 2011-04-26T12:01:18Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007017
comment: Temporal ordering number - 393. Should not be used to stage embryos whose development is at temperatures other than 25'C.

Axiom
annotated source: embryonic stage 17(iii)
annotated property: definition
annotated target: Hours 4-6 of embryonic stage 17 at 25'C. (Approximately 20-22 hours at 25'C after egg laying).
database_cross_reference: FBC:DOS

embryonic stage 17(iv)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 17(iii)
definition: Hours 6-8 (the last two hours) of embryonic stage 17 at 25'C. (Approximately 22-24 hours at 25'C after egg laying).
contributor: http://orcid.org/0000-0002-7073-9172
date: 2011-04-26T12:03:14Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007018
comment: Temporal ordering number - 394. Should not be used to stage embryos whose development is at temperatures other than 25'C.

Axiom
annotated source: embryonic stage 17(iv)
annotated property: definition
annotated target: Hours 6-8 (the last two hours) of embryonic stage 17 at 25'C. (Approximately 22-24 hours at 25'C after egg laying).
database_cross_reference: FBC:DOS

third instar - uncleared gut stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: wandering third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: early third instar larval stage
definition: The substage of the wandering third instar larval stage, prior to the beginning of clearance of the gut.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007019
comment: Temporal ordering number - 462. This is commonly assayed by adding 0.5% bromophenol blue to the food and looking for wandering third instar larvae with the same color guts (dark blue) as feeding larvae (Andres and Thummel, 1994). Larvae at this stage are in chromosomal puff stage 1 (Andres and Thummel, 1994).

Axiom
annotated source: third instar - uncleared gut stage
annotated property: definition
annotated target: The substage of the wandering third instar larval stage, prior to the beginning of clearance of the gut.
database_cross_reference: FlyBase:FBrf0076598

third instar - partially cleared gut stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: wandering third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar - uncleared gut stage
definition: The substage of the wandering third instar larval stage when the larva has partially cleared its gut contents.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007020
comment: Temporal ordering number - 465. This is commonly assayed by adding 0.5% bromophenol blue to the food and looking for wandering third instar larvae with lighter colored guts (light blue) than feeding larvae (Andres and Thummel, 1994). Larvae at this stage are mainly in chromosomal puff stages 2-7 (Andres and Thummel, 1994).

Axiom
annotated source: third instar - partially cleared gut stage
annotated property: definition
annotated target: The substage of the wandering third instar larval stage when the larva has partially cleared its gut contents.
database_cross_reference: FlyBase:FBrf0076598

third instar - cleared gut stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: wandering third instar larval stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: third instar - partially cleared gut stage
definition: The substage of the wandering third instar larval stage when the larva has cleared its gut contents.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007021
comment: Temporal ordering number - 467. This is commonly assayed by adding 0.5% bromophenol blue to the food and looking for wandering third instar larvae with guts lacking any blue stain (Andres and Thummel, 1994). Larvae at this stage are mainly in chromosomal puff stages 7-9 and pupate within 1-6 hours (Andres and Thummel, 1994.

Axiom
annotated source: third instar - cleared gut stage
annotated property: definition
annotated target: The substage of the wandering third instar larval stage when the larva has cleared its gut contents.
database_cross_reference: FlyBase:FBrf0076598

embryonic cycle interphase
type: Class
equivalent class: Class
  intersection of: interphase
  intersection of: Restriction
    on property: substage of
    some values from: embryonic cycle
subclass of: biological process
definition: The interphase (GO:0051325) of an embryonic cycle.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007022

Axiom
annotated source: embryonic cycle interphase
annotated property: definition
annotated target: The interphase (GO:0051325) of an embryonic cycle.
database_cross_reference: FBC:DOS

embryonic cycle M-phase
type: Class
equivalent class: Class
  intersection of: M phase
  intersection of: Restriction
    on property: substage of
    some values from: embryonic cycle
subclass of: biological process
definition: The M-phase (GO:0000279) of an embryonic cycle.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007023

Axiom
annotated source: embryonic cycle M-phase
annotated property: definition
annotated target: The M-phase (GO:0000279) of an embryonic cycle.
database_cross_reference: FBC:DOS

biological process
type: Class
subclass of: occurrent
definition: The execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module.
database_cross_reference: GO:0008150
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007024

Axiom
annotated source: biological process
annotated property: definition
annotated target: The execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module.
database_cross_reference: GO:0008150

immature adult stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage of
  some values from: day 0 of adulthood
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: P-stage
subclass of: Restriction
  on property: immediately precedes
  some values from: mature adult stage
definition: The developmental stage that lasts from eclosion of the adult from the pupal case until tanning is complete (the end of adult stage A3).
contributor: http://orcid.org/0000-0002-7073-9172
date: 2013-01-08T20:06:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007025
comment: Temporal ordering number - 782.

Axiom
annotated source: immature adult stage
annotated property: definition
annotated target: The developmental stage that lasts from eclosion of the adult from the pupal case until tanning is complete (the end of adult stage A3).
database_cross_reference: FBC:DOS

mature adult stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: adult stage A3
subclass of: Restriction
  on property: immediately preceded by
  some values from: immature adult stage
definition: Life stage from the end of adult stage A3, when tanning is complete, to death.
contributor: http://orcid.org/0000-0002-7073-9172
date: 2013-01-10T13:03:54Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007026

Axiom
annotated source: mature adult stage
annotated property: definition
annotated target: Life stage from the end of adult stage A3, when tanning is complete, to death.
database_cross_reference: FBC:DOS

day 0 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P15
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage P15(ii)
subclass of: Restriction
  on property: immediately preceded by
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: P-stage
definition: The day of eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007075
comment: Temporal ordering number - 780.

Axiom
annotated source: day 0 of adulthood
annotated property: definition
annotated target: The day of eclosion.
database_cross_reference: FBC:DOS

day 1 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 0 of adulthood
definition: 1st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007076
comment: Temporal ordering number - 810.

Axiom
annotated source: day 1 of adulthood
annotated property: definition
annotated target: 1st day after eclosion.
database_cross_reference: FBC:DOS

day 2 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 1 of adulthood
definition: 2nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007077
comment: Temporal ordering number - 820.

Axiom
annotated source: day 2 of adulthood
annotated property: definition
annotated target: 2nd day after eclosion.
database_cross_reference: FBC:DOS

day 3 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 2 of adulthood
definition: 3rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007078
comment: Temporal ordering number - 830.

Axiom
annotated source: day 3 of adulthood
annotated property: definition
annotated target: 3rd day after eclosion.
database_cross_reference: FBC:DOS

day 4 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 3 of adulthood
definition: 4th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007079
comment: Temporal ordering number - 840.

Axiom
annotated source: day 4 of adulthood
annotated property: definition
annotated target: 4th day after eclosion.
database_cross_reference: FBC:DOS

day 5 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 4 of adulthood
definition: 5th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007080
comment: Temporal ordering number - 850.

Axiom
annotated source: day 5 of adulthood
annotated property: definition
annotated target: 5th day after eclosion.
database_cross_reference: FBC:DOS

day 6 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 5 of adulthood
definition: 6th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007081
comment: Temporal ordering number - 860.

Axiom
annotated source: day 6 of adulthood
annotated property: definition
annotated target: 6th day after eclosion.
database_cross_reference: FBC:DOS

day 7 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 6 of adulthood
definition: 7th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007082
comment: Temporal ordering number - 870.

Axiom
annotated source: day 7 of adulthood
annotated property: definition
annotated target: 7th day after eclosion.
database_cross_reference: FBC:DOS

day 8 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 7 of adulthood
definition: 8th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007083
comment: Temporal ordering number - 880.

Axiom
annotated source: day 8 of adulthood
annotated property: definition
annotated target: 8th day after eclosion.
database_cross_reference: FBC:DOS

day 9 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 8 of adulthood
definition: 9th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007084
comment: Temporal ordering number - 890.

Axiom
annotated source: day 9 of adulthood
annotated property: definition
annotated target: 9th day after eclosion.
database_cross_reference: FBC:DOS

day 10 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 9 of adulthood
definition: 10th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007085
comment: Temporal ordering number - 900.

Axiom
annotated source: day 10 of adulthood
annotated property: definition
annotated target: 10th day after eclosion.
database_cross_reference: FBC:DOS

day 11 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 10 of adulthood
definition: 11th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007086
comment: Temporal ordering number - 910.

Axiom
annotated source: day 11 of adulthood
annotated property: definition
annotated target: 11th day after eclosion.
database_cross_reference: FBC:DOS

day 12 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 11 of adulthood
definition: 12th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007087
comment: Temporal ordering number - 920.

Axiom
annotated source: day 12 of adulthood
annotated property: definition
annotated target: 12th day after eclosion.
database_cross_reference: FBC:DOS

day 13 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 12 of adulthood
definition: 13th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007088
comment: Temporal ordering number - 930.

Axiom
annotated source: day 13 of adulthood
annotated property: definition
annotated target: 13th day after eclosion.
database_cross_reference: FBC:DOS

day 14 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 13 of adulthood
definition: 14th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007089
comment: Temporal ordering number - 940.

Axiom
annotated source: day 14 of adulthood
annotated property: definition
annotated target: 14th day after eclosion.
database_cross_reference: FBC:DOS

day 15 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 14 of adulthood
definition: 15th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007090
comment: Temporal ordering number - 950.

Axiom
annotated source: day 15 of adulthood
annotated property: definition
annotated target: 15th day after eclosion.
database_cross_reference: FBC:DOS

day 16 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 15 of adulthood
definition: 16th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007091
comment: Temporal ordering number - 960.

Axiom
annotated source: day 16 of adulthood
annotated property: definition
annotated target: 16th day after eclosion.
database_cross_reference: FBC:DOS

day 17 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 16 of adulthood
definition: 17th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007092
comment: Temporal ordering number - 970.

Axiom
annotated source: day 17 of adulthood
annotated property: definition
annotated target: 17th day after eclosion.
database_cross_reference: FBC:DOS

day 18 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 17 of adulthood
definition: 18th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007093
comment: Temporal ordering number - 980.

Axiom
annotated source: day 18 of adulthood
annotated property: definition
annotated target: 18th day after eclosion.
database_cross_reference: FBC:DOS

day 19 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 18 of adulthood
definition: 19th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007094
comment: Temporal ordering number - 990.

Axiom
annotated source: day 19 of adulthood
annotated property: definition
annotated target: 19th day after eclosion.
database_cross_reference: FBC:DOS

day 20 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 19 of adulthood
definition: 20th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007095
comment: Temporal ordering number - 1000.

Axiom
annotated source: day 20 of adulthood
annotated property: definition
annotated target: 20th day after eclosion.
database_cross_reference: FBC:DOS

day 21 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 20 of adulthood
definition: 21st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007096
comment: Temporal ordering number - 1010.

Axiom
annotated source: day 21 of adulthood
annotated property: definition
annotated target: 21st day after eclosion.
database_cross_reference: FBC:DOS

day 22 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 21 of adulthood
definition: 22nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007097
comment: Temporal ordering number - 1020.

Axiom
annotated source: day 22 of adulthood
annotated property: definition
annotated target: 22nd day after eclosion.
database_cross_reference: FBC:DOS

day 23 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 22 of adulthood
definition: 23rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007098
comment: Temporal ordering number - 1030.

Axiom
annotated source: day 23 of adulthood
annotated property: definition
annotated target: 23rd day after eclosion.
database_cross_reference: FBC:DOS

day 24 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 23 of adulthood
definition: 24th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007099
comment: Temporal ordering number - 1040.

Axiom
annotated source: day 24 of adulthood
annotated property: definition
annotated target: 24th day after eclosion.
database_cross_reference: FBC:DOS

day 25 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 24 of adulthood
definition: 25th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007100
comment: Temporal ordering number - 1050.

Axiom
annotated source: day 25 of adulthood
annotated property: definition
annotated target: 25th day after eclosion.
database_cross_reference: FBC:DOS

day 26 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 25 of adulthood
definition: 26th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007101
comment: Temporal ordering number - 1060.

Axiom
annotated source: day 26 of adulthood
annotated property: definition
annotated target: 26th day after eclosion.
database_cross_reference: FBC:DOS

day 27 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 26 of adulthood
definition: 27th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007102
comment: Temporal ordering number - 1070.

Axiom
annotated source: day 27 of adulthood
annotated property: definition
annotated target: 27th day after eclosion.
database_cross_reference: FBC:DOS

day 28 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 27 of adulthood
definition: 28th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007103
comment: Temporal ordering number - 1080.

Axiom
annotated source: day 28 of adulthood
annotated property: definition
annotated target: 28th day after eclosion.
database_cross_reference: FBC:DOS

day 29 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 28 of adulthood
definition: 29th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007104
comment: Temporal ordering number - 1090.

Axiom
annotated source: day 29 of adulthood
annotated property: definition
annotated target: 29th day after eclosion.
database_cross_reference: FBC:DOS

day 30 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 29 of adulthood
definition: 30th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007105
comment: Temporal ordering number - 1100.

Axiom
annotated source: day 30 of adulthood
annotated property: definition
annotated target: 30th day after eclosion.
database_cross_reference: FBC:DOS

day 31 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 30 of adulthood
definition: 31st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007106
comment: Temporal ordering number - 1110.

Axiom
annotated source: day 31 of adulthood
annotated property: definition
annotated target: 31st day after eclosion.
database_cross_reference: FBC:DOS

day 32 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 31 of adulthood
definition: 32nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007107
comment: Temporal ordering number - 1120.

Axiom
annotated source: day 32 of adulthood
annotated property: definition
annotated target: 32nd day after eclosion.
database_cross_reference: FBC:DOS

day 33 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 32 of adulthood
definition: 33rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007108
comment: Temporal ordering number - 1130.

Axiom
annotated source: day 33 of adulthood
annotated property: definition
annotated target: 33rd day after eclosion.
database_cross_reference: FBC:DOS

day 34 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 33 of adulthood
definition: 34th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007109
comment: Temporal ordering number - 1140.

Axiom
annotated source: day 34 of adulthood
annotated property: definition
annotated target: 34th day after eclosion.
database_cross_reference: FBC:DOS

day 35 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 34 of adulthood
definition: 35th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007110
comment: Temporal ordering number - 1150.

Axiom
annotated source: day 35 of adulthood
annotated property: definition
annotated target: 35th day after eclosion.
database_cross_reference: FBC:DOS

day 36 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 35 of adulthood
definition: 36th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007111
comment: Temporal ordering number - 1160.

Axiom
annotated source: day 36 of adulthood
annotated property: definition
annotated target: 36th day after eclosion.
database_cross_reference: FBC:DOS

day 37 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 36 of adulthood
definition: 37th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007112
comment: Temporal ordering number - 1170.

Axiom
annotated source: day 37 of adulthood
annotated property: definition
annotated target: 37th day after eclosion.
database_cross_reference: FBC:DOS

day 38 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 37 of adulthood
definition: 38th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007113
comment: Temporal ordering number - 1180.

Axiom
annotated source: day 38 of adulthood
annotated property: definition
annotated target: 38th day after eclosion.
database_cross_reference: FBC:DOS

day 39 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 38 of adulthood
definition: 39th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007114
comment: Temporal ordering number - 1190.

Axiom
annotated source: day 39 of adulthood
annotated property: definition
annotated target: 39th day after eclosion.
database_cross_reference: FBC:DOS

day 40 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 39 of adulthood
definition: 40th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007115
comment: Temporal ordering number - 1200.

Axiom
annotated source: day 40 of adulthood
annotated property: definition
annotated target: 40th day after eclosion.
database_cross_reference: FBC:DOS

day 41 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 40 of adulthood
definition: 41st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007116
comment: Temporal ordering number - 1210.

Axiom
annotated source: day 41 of adulthood
annotated property: definition
annotated target: 41st day after eclosion.
database_cross_reference: FBC:DOS

day 42 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 41 of adulthood
definition: 42nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007117
comment: Temporal ordering number - 1220.

Axiom
annotated source: day 42 of adulthood
annotated property: definition
annotated target: 42nd day after eclosion.
database_cross_reference: FBC:DOS

day 43 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 42 of adulthood
definition: 43rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007118
comment: Temporal ordering number - 1230.

Axiom
annotated source: day 43 of adulthood
annotated property: definition
annotated target: 43rd day after eclosion.
database_cross_reference: FBC:DOS

day 44 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 43 of adulthood
definition: 44th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007119
comment: Temporal ordering number - 1240.

Axiom
annotated source: day 44 of adulthood
annotated property: definition
annotated target: 44th day after eclosion.
database_cross_reference: FBC:DOS

day 45 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 44 of adulthood
definition: 45th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007120
comment: Temporal ordering number - 1250.

Axiom
annotated source: day 45 of adulthood
annotated property: definition
annotated target: 45th day after eclosion.
database_cross_reference: FBC:DOS

day 46 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 45 of adulthood
definition: 46th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007121
comment: Temporal ordering number - 1260.

Axiom
annotated source: day 46 of adulthood
annotated property: definition
annotated target: 46th day after eclosion.
database_cross_reference: FBC:DOS

day 47 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 46 of adulthood
definition: 47th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007122
comment: Temporal ordering number - 1270.

Axiom
annotated source: day 47 of adulthood
annotated property: definition
annotated target: 47th day after eclosion.
database_cross_reference: FBC:DOS

day 48 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 47 of adulthood
definition: 48th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007123
comment: Temporal ordering number - 1280.

Axiom
annotated source: day 48 of adulthood
annotated property: definition
annotated target: 48th day after eclosion.
database_cross_reference: FBC:DOS

day 49 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 48 of adulthood
definition: 49th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007124
comment: Temporal ordering number - 1290.

Axiom
annotated source: day 49 of adulthood
annotated property: definition
annotated target: 49th day after eclosion.
database_cross_reference: FBC:DOS

day 50 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 49 of adulthood
definition: 50th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007125
comment: Temporal ordering number - 1300.

Axiom
annotated source: day 50 of adulthood
annotated property: definition
annotated target: 50th day after eclosion.
database_cross_reference: FBC:DOS

day 51 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 50 of adulthood
definition: 51st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007126
comment: Temporal ordering number - 1310.

Axiom
annotated source: day 51 of adulthood
annotated property: definition
annotated target: 51st day after eclosion.
database_cross_reference: FBC:DOS

day 52 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 51 of adulthood
definition: 52nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007127
comment: Temporal ordering number - 1320.

Axiom
annotated source: day 52 of adulthood
annotated property: definition
annotated target: 52nd day after eclosion.
database_cross_reference: FBC:DOS

day 53 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 52 of adulthood
definition: 53rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007128
comment: Temporal ordering number - 1330.

Axiom
annotated source: day 53 of adulthood
annotated property: definition
annotated target: 53rd day after eclosion.
database_cross_reference: FBC:DOS

day 54 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 53 of adulthood
definition: 54th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007129
comment: Temporal ordering number - 1340.

Axiom
annotated source: day 54 of adulthood
annotated property: definition
annotated target: 54th day after eclosion.
database_cross_reference: FBC:DOS

day 55 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 54 of adulthood
definition: 55th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007130
comment: Temporal ordering number - 1350.

Axiom
annotated source: day 55 of adulthood
annotated property: definition
annotated target: 55th day after eclosion.
database_cross_reference: FBC:DOS

day 56 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 55 of adulthood
definition: 56th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007131
comment: Temporal ordering number - 1360.

Axiom
annotated source: day 56 of adulthood
annotated property: definition
annotated target: 56th day after eclosion.
database_cross_reference: FBC:DOS

day 57 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 56 of adulthood
definition: 57th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007132
comment: Temporal ordering number - 1370.

Axiom
annotated source: day 57 of adulthood
annotated property: definition
annotated target: 57th day after eclosion.
database_cross_reference: FBC:DOS

day 58 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 57 of adulthood
definition: 58th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007133
comment: Temporal ordering number - 1380.

Axiom
annotated source: day 58 of adulthood
annotated property: definition
annotated target: 58th day after eclosion.
database_cross_reference: FBC:DOS

day 59 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 58 of adulthood
definition: 59th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007134
comment: Temporal ordering number - 1390.

Axiom
annotated source: day 59 of adulthood
annotated property: definition
annotated target: 59th day after eclosion.
database_cross_reference: FBC:DOS

day 60 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 59 of adulthood
definition: 60th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007135
comment: Temporal ordering number - 1400.

Axiom
annotated source: day 60 of adulthood
annotated property: definition
annotated target: 60th day after eclosion.
database_cross_reference: FBC:DOS

early extended germ band stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage of
  some values from: extended germ band stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: embryonic stage 8
definition: A collective term for stages 9 and 10.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00014201
comment: Temporal ordering number - 270.

Axiom
annotated source: early extended germ band stage
annotated property: definition
annotated target: A collective term for stages 9 and 10.
database_cross_reference: FBC:DOS

day 61 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 60 of adulthood
definition: 61st day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010001
comment: Temporal ordering number - 1410.

Axiom
annotated source: day 61 of adulthood
annotated property: definition
annotated target: 61st day after eclosion.
database_cross_reference: FBC:DPG

day 62 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 61 of adulthood
definition: 62nd day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010002
comment: Temporal ordering number - 1420.

Axiom
annotated source: day 62 of adulthood
annotated property: definition
annotated target: 62nd day after eclosion.
database_cross_reference: FBC:DPG

day 63 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 62 of adulthood
definition: 63rd day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010003
comment: Temporal ordering number - 1430.

Axiom
annotated source: day 63 of adulthood
annotated property: definition
annotated target: 63rd day after eclosion.
database_cross_reference: FBC:DPG

day 64 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 63 of adulthood
definition: 64th day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010004
comment: Temporal ordering number - 1440.

Axiom
annotated source: day 64 of adulthood
annotated property: definition
annotated target: 64th day after eclosion.
database_cross_reference: FBC:DPG

day 65 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 64 of adulthood
definition: 65th day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010005
comment: Temporal ordering number - 1450.

Axiom
annotated source: day 65 of adulthood
annotated property: definition
annotated target: 65th day after eclosion.
database_cross_reference: FBC:DPG

day 66 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 65 of adulthood
definition: 66th day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010006
comment: Temporal ordering number - 1460.

Axiom
annotated source: day 66 of adulthood
annotated property: definition
annotated target: 66th day after eclosion.
database_cross_reference: FBC:DPG

day 67 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 66 of adulthood
definition: 67th day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010007
comment: Temporal ordering number - 1470.

Axiom
annotated source: day 67 of adulthood
annotated property: definition
annotated target: 67th day after eclosion.
database_cross_reference: FBC:DPG

day 68 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 67 of adulthood
definition: 68th day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010008
comment: Temporal ordering number - 1480.

Axiom
annotated source: day 68 of adulthood
annotated property: definition
annotated target: 68th day after eclosion.
database_cross_reference: FBC:DPG

day 69 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 68 of adulthood
definition: 69th day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010009
comment: Temporal ordering number - 1490.

Axiom
annotated source: day 69 of adulthood
annotated property: definition
annotated target: 69th day after eclosion.
database_cross_reference: FBC:DPG

day 70 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage of
  some values from: adult stage
subclass of: Restriction
  on property: immediately preceded by
  some values from: day 69 of adulthood
definition: 70th day after eclosion.
contributor: https://orcid.org/0000-0002-6095-8718
date: 2024-01-15T17:54:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:0010010
comment: Temporal ordering number - 1500.

Axiom
annotated source: day 70 of adulthood
annotated property: definition
annotated target: 70th day after eclosion.
database_cross_reference: FBC:DPG

FBdv root 00000000
type: Class
IAO_0000231: IAO_0000227
term replaced by: Drosophila life
deprecated: true

mitotic M phase
type: Class
equivalent class: Class
  intersection of: M phase
  intersection of: Restriction
    on property: happens during
    some values from: mitotic cell cycle
subclass of: M phase
subclass of: mitotic cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
has_exact_synonym: M phase of mitotic cell cycle
has_exact_synonym: M-phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000087
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: cell cycle
  intersection of: Restriction
    on property: has part
    some values from: mitotic nuclear division
subclass of: cell cycle
subclass of: Restriction
  on property: has part
  some values from: mitotic nuclear division
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has_alternative_id: GO:0007067
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
has_related_synonym: mitosis
id: GO:0000278
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.

Axiom
annotated source: mitotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
database_cross_reference: Reactome:69278

M phase
type: Class
subclass of: cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: Wikipedia:M_phase
has_exact_synonym: M-phase
has_obo_namespace: biological_process
id: GO:0000279
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: GOC:mtg_cell_cycle

nuclear division
type: Class
subclass of: organelle fission
definition: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
has_obo_namespace: biological_process
has_related_synonym: karyokinesis
id: GO:0000280

Axiom
annotated source: nuclear division
annotated property: definition
annotated target: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
database_cross_reference: GOC:mah

molecular_function
type: Class
definition: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
has_alternative_id: GO:0005554
has_exact_synonym: molecular function
has_obo_namespace: molecular_function
id: GO:0003674
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.

Axiom
annotated source: molecular_function
annotated property: definition
annotated target: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
database_cross_reference: GOC:pdt

catalytic activity
type: Class
subclass of: molecular_function
definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: Wikipedia:Enzyme
has_exact_synonym: enzyme activity
has_obo_namespace: molecular_function
id: GO:0003824

Axiom
annotated source: catalytic activity
annotated property: definition
annotated target: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0198506732

Axiom
annotated source: catalytic activity
annotated property: has_exact_synonym
annotated target: enzyme activity
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

organelle organization
type: Class
subclass of: cellular component organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
has_alternative_id: GO:1902589
has_exact_synonym: organelle organisation
has_exact_synonym: single organism organelle organization
has_obo_namespace: biological_process
has_related_synonym: organelle organization and biogenesis
has_related_synonym: single-organism organelle organization
id: GO:0006996

Axiom
annotated source: organelle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:mah

Axiom
annotated source: organelle organization
annotated property: has_exact_synonym
annotated target: single organism organelle organization
database_cross_reference: GOC:TermGenie

Axiom
annotated source: organelle organization
annotated property: has_related_synonym
annotated target: organelle organization and biogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

cell cycle
type: Class
subclass of: cellular process
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: Wikipedia:Cell_cycle
has_exact_synonym: cell-division cycle
has_obo_namespace: biological_process
id: GO:0007049

Axiom
annotated source: cell cycle
annotated property: definition
annotated target: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_cell_cycle

multicellular organism development
type: Class
subclass of: multicellular organismal process
subclass of: anatomical structure development
definition: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
has_obo_namespace: biological_process
id: GO:0007275
comment: Note that this term was 'developmental process'.

Axiom
annotated source: multicellular organism development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

biological_process
type: Class
definition: A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
has_alternative_id: GO:0044699
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_exact_synonym: physiological process
has_obo_namespace: biological_process
has_related_synonym: single organism process
has_related_synonym: single-organism process
id: GO:0008150
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.

Axiom
annotated source: biological_process
annotated property: definition
annotated target: A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
database_cross_reference: GOC:pdt

embryo development
type: Class
subclass of: multicellular organism development
definition: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
has_alternative_id: GO:0009795
has_broad_synonym: embryogenesis and morphogenesis
database_cross_reference: Wikipedia:Embryogenesis
has_exact_synonym: embryogenesis
has_exact_synonym: embryonal development
has_obo_namespace: biological_process
id: GO:0009790

Axiom
annotated source: embryo development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_sensu

cellular process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
has_alternative_id: GO:0008151
has_alternative_id: GO:0044763
has_alternative_id: GO:0050875
has_exact_synonym: cell physiology
has_exact_synonym: cellular physiological process
has_narrow_synonym: cell growth and/or maintenance
has_obo_namespace: biological_process
has_related_synonym: single-organism cellular process
id: GO:0009987
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.

Axiom
annotated source: cellular process
annotated property: definition
annotated target: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete

cellular component organization
type: Class
subclass of: cellular component organization or biogenesis
definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
has_alternative_id: GO:0044235
has_alternative_id: GO:0071842
has_exact_synonym: cell organisation
has_exact_synonym: cellular component organisation at cellular level
has_exact_synonym: cellular component organisation in other organism
has_exact_synonym: cellular component organization at cellular level
has_exact_synonym: cellular component organization in other organism
has_obo_namespace: biological_process
has_related_synonym: cell organization and biogenesis
id: GO:0016043

Axiom
annotated source: cellular component organization
annotated property: definition
annotated target: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:ai
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation in other organism
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_related_synonym
annotated target: cell organization and biogenesis
database_cross_reference: GOC:mah

kinase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
subclass of: Restriction
  on property: is kinase activity
  has self: true
definition: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: Reactome:R-HSA-6788855
database_cross_reference: Reactome:R-HSA-6788867
has_exact_synonym: phosphokinase activity
has_obo_namespace: molecular_function
id: GO:0016301
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.

Axiom
annotated source: kinase activity
annotated property: definition
annotated target: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: ISBN:0198506732

FN3KRP phosphorylates PsiAm, RibAm
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788855

FN3K phosphorylates ketosamines
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788867

transferase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2.-.-.-
database_cross_reference: Reactome:R-HSA-1483089
database_cross_reference: Reactome:R-HSA-1483186
database_cross_reference: Reactome:R-HSA-5668414
database_cross_reference: Reactome:R-HSA-8868783
has_obo_namespace: molecular_function
id: GO:0016740

Axiom
annotated source: transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: ISBN:0198506732

PE is converted to PS by PTDSS2
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483089

PC is converted to PS by PTDSS1
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483186

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5668414

TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868783

transferase activity, transferring phosphorus-containing groups
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.7.-.-
has_obo_namespace: molecular_function
id: GO:0016772
comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.

Axiom
annotated source: transferase activity, transferring phosphorus-containing groups
annotated property: definition
annotated target: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

cell cycle process
type: Class
equivalent class: Class
  intersection of: cellular process
  intersection of: Restriction
    on property: part of
    some values from: cell cycle
subclass of: cellular process
subclass of: Restriction
  on property: part of
  some values from: cell cycle
definition: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
has_obo_namespace: biological_process
id: GO:0022402

Axiom
annotated source: cell cycle process
annotated property: definition
annotated target: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_cell_cycle

cell cycle phase
type: Class
subclass of: biological phase
definition: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
id: GO:0022403
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: cell cycle phase
annotated property: definition
annotated target: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
database_cross_reference: GOC:mtg_cell_cycle

multicellular organismal process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
has_alternative_id: GO:0044707
has_alternative_id: GO:0050874
has_exact_synonym: organismal physiological process
has_obo_namespace: biological_process
has_related_synonym: single-multicellular organism process
id: GO:0032501

Axiom
annotated source: multicellular organismal process
annotated property: definition
annotated target: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
database_cross_reference: GOC:curators
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

developmental process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
has_alternative_id: GO:0044767
has_narrow_synonym: development
has_obo_namespace: biological_process
has_related_synonym: single-organism developmental process
id: GO:0032502

Axiom
annotated source: developmental process
annotated property: definition
annotated target: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
database_cross_reference: GOC:isa_complete

biological phase
type: Class
subclass of: biological_process
disjoint with: cellular component organization or biogenesis
definition: A distinct period or stage in a biological process or cycle.
has_obo_namespace: biological_process
id: GO:0044848
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.

Axiom
annotated source: biological phase
annotated property: definition
annotated target: A distinct period or stage in a biological process or cycle.
database_cross_reference: GOC:jl

mitotic cell cycle, embryonic
type: Class
subclass of: mitotic cell cycle
subclass of: Restriction
  on property: part of
  some values from: embryo development
definition: The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo.
has_obo_namespace: biological_process
id: GO:0045448

Axiom
annotated source: mitotic cell cycle, embryonic
annotated property: definition
annotated target: The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo.
database_cross_reference: GOC:go_curators

organelle fission
type: Class
subclass of: organelle organization
definition: The creation of two or more organelles by division of one organelle.
has_obo_namespace: biological_process
id: GO:0048285

Axiom
annotated source: organelle fission
annotated property: definition
annotated target: The creation of two or more organelles by division of one organelle.
database_cross_reference: GOC:jid

anatomical structure development
type: Class
subclass of: developmental process
definition: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
has_exact_synonym: development of an anatomical structure
has_obo_namespace: biological_process
id: GO:0048856

Axiom
annotated source: anatomical structure development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
database_cross_reference: GO_REF:0000021

interphase
type: Class
subclass of: cell cycle phase
definition: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
has_broad_synonym: resting phase
database_cross_reference: Wikipedia:Interphase
has_exact_synonym: karyostasis
has_obo_namespace: biological_process
id: GO:0051325
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: interphase
annotated property: definition
annotated target: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
database_cross_reference: GOC:mtg_cell_cycle

mitotic interphase
type: Class
equivalent class: Class
  intersection of: interphase
  intersection of: Restriction
    on property: happens during
    some values from: mitotic cell cycle
subclass of: interphase
subclass of: mitotic cell cycle phase
definition: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
has_exact_synonym: interphase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0051329
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic interphase
annotated property: definition
annotated target: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
database_cross_reference: GOC:mtg_cell_cycle

cellular component organization or biogenesis
type: Class
subclass of: cellular process
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
has_alternative_id: GO:0071841
has_exact_synonym: cellular component organisation or biogenesis
has_exact_synonym: cellular component organisation or biogenesis at cellular level
has_exact_synonym: cellular component organization or biogenesis at cellular level
has_obo_namespace: biological_process
id: GO:0071840

Axiom
annotated source: cellular component organization or biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular component organisation or biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular component organisation or biogenesis at cellular level
database_cross_reference: GOC:mah

mitotic cell cycle phase
type: Class
equivalent class: Class
  intersection of: cell cycle phase
  intersection of: Restriction
    on property: happens during
    some values from: mitotic cell cycle
subclass of: cell cycle phase
subclass of: Restriction
  on property: happens during
  some values from: mitotic cell cycle
definition: One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
id: GO:0098763
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic cell cycle phase
annotated property: definition
annotated target: One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
database_cross_reference: GOC:dos

mitotic nuclear division
type: Class
equivalent class: Class
  intersection of: nuclear division
  intersection of: Restriction
    on property: part of
    some values from: mitotic cell cycle
subclass of: nuclear division
subclass of: mitotic cell cycle process
definition: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
has_exact_synonym: mitosis
has_obo_namespace: biological_process
id: GO:0140014

Axiom
annotated source: mitotic nuclear division
annotated property: definition
annotated target: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
database_cross_reference: ISBN:0198547684

mitotic cell cycle process
type: Class
equivalent class: Class
  intersection of: cellular process
  intersection of: Restriction
    on property: part of
    some values from: mitotic cell cycle
subclass of: cell cycle process
subclass of: Restriction
  on property: part of
  some values from: mitotic cell cycle
definition: A process that is part of the mitotic cell cycle.
has_obo_namespace: biological_process
id: GO:1903047

Axiom
annotated source: mitotic cell cycle process
annotated property: definition
annotated target: A process that is part of the mitotic cell cycle.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GO_REF:0000060

inferring direct positive reg edge from input to regulatory subfunction
type: Imp
body: IndividualPropertyAtom
  property predicate: input of
  argument1: B
  argument2: C
body: IndividualPropertyAtom
  property predicate: enabled by
  argument1: A
  argument2: B
body: IndividualPropertyAtom
  property predicate: has positive regulatory component activity
  argument1: D
  argument2: C
head: IndividualPropertyAtom
  property predicate: directly positively regulates
  argument1: A
  argument2: D

effector input is compound function input
type: Imp
body: IndividualPropertyAtom
  property predicate: has input
  argument1: eff
  argument2: in
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
head: IndividualPropertyAtom
  property predicate: has input
  argument1: mf
  argument2: in

Input of effector is input of its parent MF
type: Imp
body: IndividualPropertyAtom
  property predicate: has input
  argument1: mf
  argument2: in
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
head: IndividualPropertyAtom
  property predicate: has input
  argument1: eff
  argument2: in

Imp
comment: if effector directly regulates X, its parent MF directly regulates X
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
body: IndividualPropertyAtom
  property predicate: directly regulates
  argument1: mf
  argument2: mf2
head: IndividualPropertyAtom
  property predicate: directly regulates
  argument1: eff
  argument2: mf2

Imp
comment: if effector directly positively regulates X, its parent MF directly positively regulates X
body: IndividualPropertyAtom
  property predicate: directly positively regulates
  argument1: mf
  argument2: mf2
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
head: IndividualPropertyAtom
  property predicate: directly positively regulates
  argument1: eff
  argument2: mf2

if effector directly negatively regulates X, its parent MF directly negatively regulates X
type: Imp
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
body: IndividualPropertyAtom
  property predicate: directly negatively regulates
  argument1: mf
  argument2: mf2
head: IndividualPropertyAtom
  property predicate: directly negatively regulates
  argument1: eff
  argument2: mf2

'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).
type: Imp
body: IndividualPropertyAtom
  property predicate: causally downstream of
  argument1: x
  argument2: y
body: IndividualPropertyAtom
  property predicate: overlaps
  argument1: x
  argument2: y
head: ClassAtom
  class predicate: Nothing
  argument1: x
head: ClassAtom
  class predicate: Nothing
  argument1: y

'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).
type: Imp
body: IndividualPropertyAtom
  property predicate: causally upstream of
  argument1: x
  argument2: y
body: IndividualPropertyAtom
  property predicate: overlaps
  argument1: x
  argument2: y
head: ClassAtom
  class predicate: Nothing
  argument1: x
head: ClassAtom
  class predicate: Nothing
  argument1: y

enabling an MF enables its parts
comment: GP(X)-enables->MF(Y)-has_part->MF(Z) => GP(X) enables MF(Z), e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase coupled transporter activity' has_part 'ATPase activity' then GP(X) enables 'ATPase activity'
type: Imp
body: ClassAtom
  class predicate: molecular_function
  argument1: y
body: IndividualPropertyAtom
  property predicate: enables
  argument1: x
  argument2: y
body: IndividualPropertyAtom
  property predicate: has part
  argument1: y
  argument2: z
head: IndividualPropertyAtom
  property predicate: enables
  argument1: x
  argument2: z

inferring direct reg edge from input to regulatory subfunction
comment: If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X. Note: this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this.
type: Imp
body: IndividualPropertyAtom
  property predicate: input of
  argument1: B
  argument2: C
body: IndividualPropertyAtom
  property predicate: enabled by
  argument1: A
  argument2: B
body: IndividualPropertyAtom
  property predicate: has regulatory component activity
  argument1: D
  argument2: C
head: IndividualPropertyAtom
  property predicate: directly regulates
  argument1: A
  argument2: D

inferring direct neg reg edge from input to regulatory subfunction
type: Imp
body: IndividualPropertyAtom
  property predicate: input of
  argument1: B
  argument2: C
body: IndividualPropertyAtom
  property predicate: enabled by
  argument1: A
  argument2: B
body: IndividualPropertyAtom
  property predicate: has negative regulatory component activity
  argument1: D
  argument2: C
head: IndividualPropertyAtom
  property predicate: directly negatively regulates
  argument1: A
  argument2: D