FlyBase Developmental Ontology (FBdv)
type: Ontology
version IRI: fbdv.owl
IAO_0000700: Drosophila life
IAO_0000700: developmental stage
IAO_0000700: age
IAO_0000700: biological process
creator: http://orcid.org/0000-0002-1373-1705
creator: http://orcid.org/0000-0002-7073-9172
creator: https://orcid.org/0000-0001-5948-3092
creator: https://orcid.org/0000-0002-0027-0858
description: An ontology of Drosophila melanogaster developmental stages.
license: https://creativecommons.org/licenses/by/3.0/
namespace-id-rule: * FBdv:$sequence(8,7000,10000)$
date: 13:10:2021 08:59
default-namespace: FlyBase_development_CV
has_obo_format_version: 1.2
version info: 2021-10-13

definition
type: AnnotationProperty
IAO_0000114: IAO_0000122

term replaced by
type: AnnotationProperty
IAO_0000114: IAO_0000125

is a defining property chain axiom
type: AnnotationProperty
definition: If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL

is a defining property chain axiom where second argument is reflexive
type: AnnotationProperty
definition: If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R.

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck do not manually annotate
type: AnnotationProperty
comment: Term not to be used for direct manual annotation
sub property of: subset_property

goslim ChEMBL
type: AnnotationProperty
comment: ChEMBL GO slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL GO slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

gosubset prok
type: AnnotationProperty
comment: Prokaryotic GO subset
sub property of: subset_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

namespace-id-rule
type: AnnotationProperty

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
sub property of: overlaps
inverse of: has part
type: TransitiveProperty
IAO_0000111: is part of
IAO_0000112: my brain is part of my body (continuant parthood, two material entities)
IAO_0000112: my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
IAO_0000112: this day is part of this year (occurrent parthood)
definition: a core relation that holds between a part and its whole
IAO_0000116: Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
IAO_0000116: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
IAO_0000116: Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
IAO_0000118: part_of
RO_0001900: RO_0001901
RO_0040042: continuant
RO_0040042: occurrent
RO_0040042: independent continuant
RO_0040042: realizable entity
RO_0040042: quality
RO_0040042: specifically dependent continuant
RO_0040042: BFO_0000031
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
in subset: valid for go annotation extension
in subset: valid for go gp2term
in subset: valid for go ontology
in subset: valid for gocam
shorthand: part_of

has part
type: ObjectProperty
sub property of: overlaps
type: TransitiveProperty
IAO_0000111: has part
IAO_0000112: my body has part my brain (continuant parthood, two material entities)
IAO_0000112: my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
IAO_0000112: this year has part this day (occurrent parthood)
definition: a core relation that holds between a whole and its part
IAO_0000116: Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
IAO_0000116: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
IAO_0000116: Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
IAO_0000118: has_part
RO_0001900: RO_0001901
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: has_part

preceded by
type: ObjectProperty
sub property of: ends after
inverse of: precedes
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: starts during
property chain axiom: happens during
IAO_0000111: preceded by
definition: x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
IAO_0000116: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
IAO_0000118: is preceded by
IAO_0000118: preceded_by
source: http://www.obofoundry.org/ro/#OBO_REL:preceded_by
in subset: ro-eco

precedes
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: happens during
IAO_0000111: precedes
definition: x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
in subset: ro-eco

substage_of
type: ObjectProperty
sub property of: occurent part of
sub property of: happens during
type: TransitiveProperty
database_cross_reference: FBdv:00018001
has_obo_namespace: relationship
id: substage_of
shorthand: substage_of
comment: Creating this relation as a temporary fix, pending adding the axiom occurrent_part_of subproperty of happens_during to RO.

characteristic of
type: ObjectProperty
sub property of: characteristic of part of
inverse of: has characteristic
type: FunctionalProperty
IAO_0000111: inheres in
IAO_0000112: this fragility is a characteristic of this vase
IAO_0000112: this red color is a characteristic of this apple
definition: a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
IAO_0000118: inheres_in
RO_0001900: RO_0001901
comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.

has characteristic
type: ObjectProperty
type: InverseFunctionalProperty
range: specifically dependent continuant
IAO_0000111: bearer of
IAO_0000112: this apple is bearer of this red color
IAO_0000112: this vase is bearer of this fragility
definition: Inverse of characteristic_of
IAO_0000116: A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
IAO_0000118: bearer_of
IAO_0000118: is bearer of
RO_0001900: RO_0001901

participates in
type: ObjectProperty
inverse of: has participant
domain: continuant
range: occurrent
IAO_0000111: participates in
IAO_0000112: this blood clot participates in this blood coagulation
IAO_0000112: this input material (or this output material) participates in this process
IAO_0000112: this investigator participates in this investigation
definition: a relation between a continuant and a process, in which the continuant is somehow involved in the process
IAO_0000118: participates_in

has participant
type: ObjectProperty
domain: occurrent
range: continuant
property chain axiom: has part
IAO_0000111: has participant
IAO_0000112: this blood coagulation has participant this blood clot
IAO_0000112: this investigation has participant this investigator
IAO_0000112: this process has participant this input material (or this output material)
definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process
IAO_0000116: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
IAO_0000118: has_participant
source: http://www.obofoundry.org/ro/#OBO_REL:has_participant

function of
type: ObjectProperty
sub property of: characteristic of
inverse of: has function
domain: function
IAO_0000112: this catalysis function is a function of this enzyme
definition: a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence
IAO_0000116: A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists.
IAO_0000118: function_of
IAO_0000118: is function of
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.

quality of
type: ObjectProperty
sub property of: characteristic of
inverse of: has quality
IAO_0000112: this red color is a quality of this apple
definition: a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
IAO_0000116: A quality inheres in its bearer at all times for which the quality exists.
IAO_0000118: is quality of
IAO_0000118: quality_of
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.

role of
type: ObjectProperty
sub property of: characteristic of
inverse of: has role
IAO_0000112: this investigator role is a role of this person
definition: a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
IAO_0000116: A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.
IAO_0000118: is role of
IAO_0000118: role_of
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.

has function
type: ObjectProperty
sub property of: has characteristic
domain: independent continuant
range: function
IAO_0000112: this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)
definition: a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
IAO_0000116: A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.
IAO_0000118: has_function

has quality
type: ObjectProperty
sub property of: has characteristic
range: quality
IAO_0000112: this apple has quality this red color
definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
IAO_0000116: A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
IAO_0000118: has_quality

has role
type: ObjectProperty
sub property of: has characteristic
domain: independent continuant
range: role
IAO_0000112: this person has role this investigator role (more colloquially: this person has this role of investigator)
definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
IAO_0000116: A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
IAO_0000118: has_role

has disposition
type: ObjectProperty
sub property of: has characteristic
inverse of: disposition of
domain: independent continuant
range: disposition
definition: a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence

disposition of
type: ObjectProperty
sub property of: characteristic of
definition: inverse of has disposition
in subset: RO_0002259
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.

occurent part of
type: ObjectProperty
sub property of: part of
sub property of: causally upstream of or within
domain: occurrent
range: occurrent
definition: A part of relation that applies only between occurents.
database_cross_reference: RO:0002012
has_obo_namespace: FlyBase_development_CV
id: occurent_part_of
shorthand: occurent_part_of
label: occurent_part_of

has regulatory component activity
type: ObjectProperty
sub property of: has component activity
sub property of: regulated by
definition: A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.
created by: dos
creation date: 2017-05-24T09:30:46Z

has negative regulatory component activity
type: ObjectProperty
sub property of: has regulatory component activity
sub property of: negatively regulated by
definition: A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
created by: dos
creation date: 2017-05-24T09:31:01Z
comment: By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.

has positive regulatory component activity
type: ObjectProperty
sub property of: has regulatory component activity
sub property of: positively regulated by
definition: A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
created by: dos
creation date: 2017-05-24T09:31:17Z
comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.

has component activity
type: ObjectProperty
sub property of: has component process
created by: dos
creation date: 2017-05-24T09:44:33Z
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.

has component process
type: ObjectProperty
sub property of: has component
domain: process
range: process
definition: w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
created by: dos
creation date: 2017-05-24T09:49:21Z

directly regulated by
type: ObjectProperty
sub property of: regulated by
inverse of: directly regulates
created by: dos
creation date: 2017-09-17T13:52:24Z
comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.

Axiom
annotated source: directly regulated by
annotated property: comment
annotated target: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
database_cross_reference: GOC:dos

directly negatively regulated by
type: ObjectProperty
sub property of: directly regulated by
inverse of: directly negatively regulates
definition: Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
created by: dos
creation date: 2017-09-17T13:52:38Z

Axiom
annotated source: directly negatively regulated by
annotated property: definition
annotated target: Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
database_cross_reference: GOC:dos

directly positively regulated by
type: ObjectProperty
sub property of: directly regulated by
inverse of: directly positively regulates
definition: Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
created by: dos
creation date: 2017-09-17T13:52:47Z

Axiom
annotated source: directly positively regulated by
annotated property: definition
annotated target: Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
database_cross_reference: GOC:dos

has effector activity
type: ObjectProperty
sub property of: has component activity
type: FunctionalProperty
definition: A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
created by: dos
creation date: 2017-09-22T14:14:36Z
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.

Axiom
annotated source: has effector activity
annotated property: definition
annotated target: A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
database_cross_reference: GOC:dos

during which ends
type: ObjectProperty
sub property of: temporally related to
inverse of: ends_during
IAO_0000117: David Osumi-Sutherland
in subset: ro-eco
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002122 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

encompasses
type: ObjectProperty
sub property of: during which starts
inverse of: happens during
type: TransitiveProperty
IAO_0000117: David Osumi-Sutherland
IAO_0000118: di
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002124 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

ends after
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
property chain axiom: ends_during
property chain axiom: preceded by
IAO_0000117: David Osumi-Sutherland
in subset: ro-eco
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)

immediately_preceded_by
type: ObjectProperty
sub property of: preceded by
inverse of: immediately precedes
IAO_0000117: David Osumi-Sutherland
IAO_0000118: starts_at_end_of
database_cross_reference: RO:0002087
has_obo_namespace: FlyBase_development_CV
id: immediately_preceded_by
shorthand: immediately_preceded_by
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
label: immediately preceded by

during which starts
type: ObjectProperty
sub property of: temporally related to
inverse of: starts during
IAO_0000117: David Osumi-Sutherland
in subset: ro-eco
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002123 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

immediately precedes
type: ObjectProperty
sub property of: precedes
IAO_0000117: David Osumi-Sutherland
IAO_0000118: ends_at_start_of
IAO_0000118: meets
RO_0002575: precedes
in subset: ro-eco
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)

starts during
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
IAO_0000117: David Osumi-Sutherland
IAO_0000118: io
in subset: ro-eco
comment: X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))

happens during
type: ObjectProperty
sub property of: starts during
sub property of: ends_during
type: TransitiveProperty
IAO_0000117: David Osumi-Sutherland
IAO_0000118: d
IAO_0000118: during
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
in subset: ro-eco
shorthand: happens_during
comment: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))

ends_during
type: ObjectProperty
sub property of: temporally related to
IAO_0000117: David Osumi-Sutherland
IAO_0000118: o
IAO_0000118: overlaps
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
in subset: ro-eco
shorthand: ends_during
comment: X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).
label: ends during

overlaps
type: ObjectProperty
sub property of: mereotopologically related to
property chain axiom: part of
property chain axiom: has part
IAO_0000114: IAO_0000125
definition: x overlaps y if and only if there exists some z such that x has part z and z part of y
IAO_0000424: http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
RO_0001900: RO_0001901
in subset: valid for go annotation extension
in subset: valid for gocam
in subset: ro-eco

Axiom
annotated source: overlaps
annotated property: propertyChainAxiom
annotated target: has part
annotated target: part of
RO_0002582: true

has component
type: ObjectProperty
sub property of: has part
IAO_0000114: IAO_0000125
definition: w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
IAO_0000116: The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity.
IAO_0000232: For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit.
RO_0001900: RO_0001901
in subset: ro-eco

develops from
type: ObjectProperty
sub property of: developmentally preceded by
inverse of: develops into
type: TransitiveProperty
domain: independent continuant
range: independent continuant
IAO_0000114: IAO_0000125
definition: x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
IAO_0000117: Chris Mungall
IAO_0000117: David Osumi-Sutherland
IAO_0000117: Melissa Haendel
IAO_0000117: Terry Meehan
comment: This is the transitive form of the develops from relation

develops into
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to develop into
sub property of: has potential to directly develop into
type: TransitiveProperty
IAO_0000114: IAO_0000125
definition: inverse of develops from
IAO_0000117: Chris Mungall
IAO_0000117: David Osumi-Sutherland
IAO_0000117: Terry Meehan
in subset: RO_0002259

regulates
type: ObjectProperty
sub property of: causally upstream of
inverse of: regulated by
type: TransitiveProperty
domain: process
range: process
property chain axiom: has effector activity
property chain axiom: directly regulates
IAO_0000114: IAO_0000125
definition: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
IAO_0000116: We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit
IAO_0000117: Chris Mungall
IAO_0000117: David Hill
IAO_0000117: Tanya Berardini
IAO_0000119: causal-relations
IAO_0000119: GO
IAO_0000232: Regulation precludes parthood; the regulatory process may not be within the regulated process.
IAO_0000589: regulates (processual)
IAO_0000600: false
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam

negatively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, negative effect
inverse of: negatively regulated by
definition: Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
IAO_0000117: Chris Mungall
IAO_0000119: causal-relations
IAO_0000589: negatively regulates (process to process)
RO_0004050: regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam

positively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, positive effect
inverse of: positively regulated by
type: TransitiveProperty
property chain axiom: negatively regulates
definition: Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
IAO_0000117: Chris Mungall
IAO_0000119: causal-relations
IAO_0000589: positively regulates (process to process)
RO_0004049: regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam

capable of
type: ObjectProperty
sub property of: capable of part of
domain: independent continuant
range: process
IAO_0000112: mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)
IAO_0000112: osteoclast SubClassOf 'capable of' some 'bone resorption'
definition: A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
IAO_0000117: Chris Mungall
IAO_0000118: has function realized in
IAO_0000119: http://www.ncbi.nlm.nih.gov/pubmed/20123131
IAO_0000119: http://www.ncbi.nlm.nih.gov/pubmed/21208450
IAO_0000232: For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".
in subset: ro-eco

capable of part of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal agent in process
property chain axiom: capable of
property chain axiom: part of
definition: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
IAO_0000117: Chris Mungall
IAO_0000118: has function in

Axiom
annotated source: capable of part of
annotated property: propertyChainAxiom
annotated target: capable of
annotated target: part of
RO_0002582: true

temporally related to
type: ObjectProperty
domain: occurrent
range: occurrent
IAO_0000114: IAO_0000125
IAO_0000117: Chris Mungall
IAO_0000119: Allen's interval algebra
IAO_0000232: Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
source: https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit
in subset: ro-eco
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.

has input
type: ObjectProperty
sub property of: has participant
inverse of: input of
domain: process
IAO_0000114: IAO_0000125
definition: p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
IAO_0000117: Chris Mungall
IAO_0000118: consumes
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
in subset: ro-eco

has developmental contribution from
type: ObjectProperty
sub property of: developmentally preceded by
inverse of: developmentally contributes to
domain: anatomical entity
range: anatomical entity
property chain axiom: has part
property chain axiom: develops from
IAO_0000112: Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]
IAO_0000114: IAO_0000125
definition: x has developmental contribution from y iff x has some part z such that z develops from y
IAO_0000117: Chris Mungall

developmentally contributes to
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to developmentally contribute to
property chain axiom: develops into
property chain axiom: part of
IAO_0000114: IAO_0000125
definition: inverse of has developmental contribution from
IAO_0000117: Chris Mungall
in subset: RO_0002259

developmentally preceded by
type: ObjectProperty
sub property of: developmentally related to
inverse of: developmentally succeeded by
domain: continuant
range: continuant
IAO_0000114: IAO_0000125
definition: Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
IAO_0000116: false
IAO_0000117: Chris Mungall
IAO_0000232: In general you should not use this relation to make assertions - use one of the more specific relations below this one
comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from

acts upstream of
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of
IAO_0000112: A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision.
definition: c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes.
in subset: valid for go gp2term

acts upstream of or within
type: ObjectProperty
sub property of: causal agent in process
property chain axiom: enables
property chain axiom: causally upstream of or within
IAO_0000112: A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway.
definition: c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.
has_related_synonym: affects
in subset: valid for go gp2term

developmentally succeeded by
type: ObjectProperty
sub property of: has developmental potential involving
IAO_0000114: IAO_0000125
definition: Inverse of developmentally preceded by
IAO_0000117: Chris Mungall

causally upstream of, positive effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, positive effect
RO_0004049: causally upstream of
creator: cjm
in subset: valid for go annotation extension
in subset: valid for gocam
comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y

causally upstream of, negative effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, negative effect
RO_0004050: causally upstream of
creator: cjm
comment: holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y

characteristic of part of
type: ObjectProperty
sub property of: depends on
property chain axiom: characteristic of
property chain axiom: part of
definition: q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.
IAO_0000116: Because part_of is transitive, inheres in is a sub-relation of characteristic of part of
IAO_0000117: Chris Mungall
IAO_0000118: inheres in part of
IAO_0000119: http://www.ncbi.nlm.nih.gov/pubmed/20064205
RO_0001900: RO_0001901

Axiom
annotated source: characteristic of part of
annotated property: propertyChainAxiom
annotated target: characteristic of
annotated target: part of
RO_0002582: true

mereotopologically related to
type: ObjectProperty
definition: A mereological relationship or a topological relationship
IAO_0000117: Chris Mungall
IAO_0000232: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
RO_0001900: RO_0001901

developmentally related to
type: ObjectProperty
definition: A relationship that holds between entities participating in some developmental process (GO:0032502)
IAO_0000117: Chris Mungall
IAO_0000232: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development

enables
type: ObjectProperty
sub property of: capable of
inverse of: enabled by
property chain axiom: has part
property chain axiom: has component activity
IAO_0000112: a particular instances of akt-2 enables some instance of protein kinase activity
IAO_0000117: Chris Mungall
IAO_0000118: catalyzes
IAO_0000118: executes
IAO_0000118: has
IAO_0000118: is catalyzing
IAO_0000118: is executing
IAO_0000232: This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
IAO_0000232: This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.
in subset: valid for go gp2term

functionally related to
type: ObjectProperty
definition: A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
IAO_0000117: Chris Mungall
IAO_0000232: This is a grouping relation that collects relations used for the purpose of connecting structure and function

part of structure that is capable of
type: ObjectProperty
sub property of: functionally related to
property chain axiom: part of
property chain axiom: capable of
definition: this relation holds between c and p when c is part of some c', and c' is capable of p.
IAO_0000117: Chris Mungall
IAO_0000118: false

Axiom
annotated source: part of structure that is capable of
annotated property: propertyChainAxiom
annotated target: part of
annotated target: capable of
is a defining property chain axiom: true

involved in
type: ObjectProperty
sub property of: participates in
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: part of
definition: c involved_in p if and only if c enables some process p', and p' is part of p
IAO_0000117: Chris Mungall
IAO_0000118: actively involved in
IAO_0000118: enables part of

enabled by
type: ObjectProperty
sub property of: has participant
sub property of: functionally related to
definition: inverse of enables
IAO_0000117: Chris Mungall
in subset: valid for gocam

regulated by
type: ObjectProperty
sub property of: causally downstream of or within
type: TransitiveProperty
domain: process
range: process
definition: inverse of regulates
IAO_0000117: Chris Mungall
IAO_0000589: regulated by (processual)
in subset: RO_0002259

negatively regulated by
type: ObjectProperty
sub property of: regulated by
definition: inverse of negatively regulates
IAO_0000117: Chris Mungall
in subset: RO_0002259

positively regulated by
type: ObjectProperty
sub property of: regulated by
definition: inverse of positively regulates
IAO_0000117: Chris Mungall
in subset: RO_0002259

input of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
definition: inverse of has input
IAO_0000117: Chris Mungall
in subset: RO_0002259
in subset: ro-eco

has developmental potential involving
type: ObjectProperty
sub property of: developmentally related to
domain: anatomical entity
range: anatomical entity
IAO_0000114: IAO_0000428
definition: x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
IAO_0000117: Chris Mungall

has potential to developmentally contribute to
type: ObjectProperty
sub property of: has developmental potential involving
IAO_0000114: IAO_0000428
definition: x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
IAO_0000117: Chris Mungall

has potential to develop into
type: ObjectProperty
sub property of: has developmental potential involving
IAO_0000114: IAO_0000428
definition: x has the potential to develop into y iff x develops into y or if x is capable of developing into y
IAO_0000117: Chris Mungall

has potential to directly develop into
type: ObjectProperty
sub property of: has potential to develop into
IAO_0000114: IAO_0000428
definition: x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y
IAO_0000117: Chris Mungall

causally downstream of
type: ObjectProperty
sub property of: preceded by
sub property of: causally downstream of or within
inverse of: causally upstream of
IAO_0000114: IAO_0000428
definition: inverse of upstream of
IAO_0000117: Chris Mungall

immediately causally downstream of
type: ObjectProperty
sub property of: immediately_preceded_by
sub property of: causally downstream of
inverse of: immediately causally upstream of
IAO_0000114: IAO_0000428
IAO_0000117: Chris Mungall

causally related to
type: ObjectProperty
IAO_0000114: IAO_0000428
definition: This relation groups causal relations between material entities and causal relations between processes
IAO_0000116: This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yiel…
IAO_0000117: Chris Mungall
IAO_0000232: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.

causally upstream of
type: ObjectProperty
sub property of: precedes
sub property of: causally upstream of or within
type: TransitiveProperty
IAO_0000114: IAO_0000428
definition: p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain
IAO_0000117: Chris Mungall
in subset: valid for go annotation extension
in subset: valid for gocam

immediately causally upstream of
type: ObjectProperty
sub property of: immediately precedes
sub property of: causally upstream of
IAO_0000114: IAO_0000428
definition: p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.
IAO_0000117: Chris Mungall
RO_0002575: causally upstream of

causally upstream of or within
type: ObjectProperty
sub property of: causal relation between processes
inverse of: causally downstream of or within
type: TransitiveProperty
definition: p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
IAO_0000116: We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2
IAO_0000117: Chris Mungall
IAO_0000118: influences (processual)
has_related_synonym: affects

causally downstream of or within
type: ObjectProperty
sub property of: causal relation between processes
type: TransitiveProperty
definition: inverse of causally upstream of or within
IAO_0000117: Chris Mungall
IAO_0000119: causal-relations
in subset: RO_0002259

involved in regulation of
type: ObjectProperty
sub property of: acts upstream of
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' regulates some p
IAO_0000117: Chris Mungall

involved in positive regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: positively regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' positively regulates some p
IAO_0000117: Chris Mungall
RO_0004049: involved in regulation of

involved in negative regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: negatively regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' negatively regulates some p
IAO_0000117: Chris Mungall
RO_0004050: involved in regulation of

involved in or involved in regulation of
type: ObjectProperty
sub property of: acts upstream of or within
sub property of: functionally related to
sub property of: causal agent in process
definition: c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p
IAO_0000116: OWL does not allow defining object properties via a Union
IAO_0000117: Chris Mungall
IAO_0000118: involved in or reguates

interacts with
type: ObjectProperty
type: SymmetricProperty
domain: material entity
range: material entity
definition: A relationship that holds between two entities in which the processes executed by the two entities are causally connected.
IAO_0000116: Considering relabeling as 'pairwise interacts with'
IAO_0000116: This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact.
IAO_0000117: Chris Mungall
IAO_0000232: Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules.
has_exact_synonym: in pairwise interaction with
in subset: ro-eco

molecularly interacts with
type: ObjectProperty
sub property of: interacts with
type: SymmetricProperty
definition: An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.
IAO_0000117: Chris Mungall
IAO_0000118: binds
IAO_0000118: molecularly binds with

phosphorylates
type: ObjectProperty
sub property of: molecularly interacts with
IAO_0000116: Axiomatization to GO to be added later
IAO_0000117: Chris Mungall
IAO_0000118: An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y.

directly regulates activity of
type: ObjectProperty
sub property of: molecularly interacts with
sub property of: regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.
IAO_0000117: Chris Mungall
IAO_0000117: Vasundra Touré
has_exact_synonym: molecularly controls

directly negatively regulates activity of
type: ObjectProperty
sub property of: directly regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: directly negatively regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.
IAO_0000117: Chris Mungall
IAO_0000117: Vasundra Touré
IAO_0000118: directly inhibits
has_exact_synonym: molecularly decreases activity of

directly positively regulates activity of
type: ObjectProperty
sub property of: directly regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: directly positively regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.
IAO_0000117: Chris Mungall
IAO_0000117: Vasundra Touré
IAO_0000118: directly activates
has_exact_synonym: molecularly increases activity of

helper property (not for use in curation)
type: ObjectProperty
IAO_0000117: Chris Mungall
IAO_0000232: This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning.

is kinase activity
type: ObjectProperty
sub property of: molecular interaction relation helper property
IAO_0000117: Chris Mungall

causal agent in process
type: ObjectProperty
sub property of: causal relation between material entity and a process
inverse of: process has causal agent
definition: A relationship between a material entity and a process where the material entity has some causal role that influences the process
IAO_0000119: causal-relations

causal relation between processes
type: ObjectProperty
sub property of: causally related to
domain: occurrent
range: occurrent
definition: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
IAO_0000117: Chris Mungall
IAO_0000119: causal-relations
IAO_0000232: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.

depends on
type: ObjectProperty
IAO_0000117: Chris Mungall

causal relation between entities
type: ObjectProperty
sub property of: causally related to
domain: continuant
range: continuant
IAO_0000116: The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch
IAO_0000117: Chris Mungall
IAO_0000119: causal-relations
IAO_0000232: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.

causally influenced by
type: ObjectProperty
sub property of: causal relation between entities
inverse of: causally influences
IAO_0000117: Chris Mungall
IAO_0000119: causal-relations
IAO_0000589: causally influenced by (entity-centric)

interaction relation helper property
type: ObjectProperty
sub property of: helper property (not for use in curation)
IAO_0000117: Chris Mungall

molecular interaction relation helper property
type: ObjectProperty
sub property of: interaction relation helper property
IAO_0000117: Chris Mungall

causally influences
type: ObjectProperty
sub property of: causal relation between entities
domain: continuant
range: continuant
property chain axiom: enables
property chain axiom: causally upstream of
property chain axiom: has input
property chain axiom: enabled by
definition: The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).
IAO_0000117: Chris Mungall
IAO_0000117: Vasundra Touré
IAO_0000119: causal-relations
IAO_0000589: causally influences (entity-centric)

directly regulates
type: ObjectProperty
sub property of: regulates
sub property of: immediately causally upstream of
definition: Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
IAO_0000117: Chris Mungall
IAO_0000119: causal-relations
IAO_0000589: directly regulates (processual)
RO_0002575: regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam

has part structure that is capable of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal relation between material entity and a process
property chain axiom: has part
property chain axiom: capable of
IAO_0000112: gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'
definition: s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p
IAO_0000117: Chris Mungall

causal relation between material entity and a process
type: ObjectProperty
sub property of: causally related to
domain: material entity
range: process
definition: A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
IAO_0000116: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
IAO_0000117: Chris Mungall
IAO_0000119: causal-relations

capable of regulating
type: ObjectProperty
sub property of: causal agent in process
property chain axiom: capable of
property chain axiom: regulates
IAO_0000112: pyrethroid -> growth
definition: Holds between c and p if and only if c is capable of some activity a, and a regulates p.
IAO_0000119: causal-relations

capable of negatively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: negatively regulates
definition: Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.
IAO_0000119: causal-relations

capable of positively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: positively regulates
IAO_0000112: renin -> arteriolar smooth muscle contraction
definition: Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.
IAO_0000119: causal-relations

process has causal agent
type: ObjectProperty
sub property of: causally related to
definition: Inverse of 'causal agent in process'
IAO_0000119: causal-relations

directly positively regulates
type: ObjectProperty
sub property of: positively regulates
sub property of: directly regulates
definition: Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.
IAO_0000119: causal-relations
IAO_0000589: directly positively regulates (process to process)
RO_0004049: directly regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam

directly negatively regulates
type: ObjectProperty
sub property of: negatively regulates
sub property of: directly regulates
definition: Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.
IAO_0000119: causal-relations
IAO_0000589: directly negatively regulates (process to process)
RO_0004050: directly regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam

enables subfunction
type: ObjectProperty
sub property of: functionally related to
property chain axiom: enables
property chain axiom: has part
definition: Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P.
created by: cjm
creation date: 2018-01-25T23:20:13Z

acts upstream of or within, positive effect
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of or within, positive effect
RO_0004049: acts upstream of or within
created by: cjm
creation date: 2018-01-26T23:49:30Z
in subset: valid for go gp2term

acts upstream of or within, negative effect
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of or within, negative effect
RO_0004050: acts upstream of or within
created by: cjm
creation date: 2018-01-26T23:49:51Z
in subset: valid for go gp2term

acts upstream of, positive effect
type: ObjectProperty
sub property of: acts upstream of
sub property of: acts upstream of or within, positive effect
property chain axiom: enables
property chain axiom: causally upstream of, positive effect
definition: c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive
RO_0004049: acts upstream of
created by: cjm
creation date: 2018-01-26T23:53:14Z
in subset: valid for go gp2term

acts upstream of, negative effect
type: ObjectProperty
sub property of: acts upstream of
sub property of: acts upstream of or within, negative effect
property chain axiom: enables
property chain axiom: causally upstream of, negative effect
definition: c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative
RO_0004050: acts upstream of
created by: cjm
creation date: 2018-01-26T23:53:22Z
in subset: valid for go gp2term

causally upstream of or within, negative effect
type: ObjectProperty
sub property of: causally upstream of or within
RO_0004050: causally upstream of or within
created by: cjm
creation date: 2018-03-13T23:55:05Z

causally upstream of or within, positive effect
type: ObjectProperty
sub property of: causally upstream of or within
RO_0004049: causally upstream of or within
created by: cjm
creation date: 2018-03-13T23:55:19Z

regulates activity of
type: ObjectProperty
sub property of: causally influences
domain: material entity
range: material entity
definition: The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.
IAO_0000117: Vasundra Touré

continuant
type: Class
subclass of: Restriction
  on property: part of
  all values from: continuant
disjoint with: occurrent
disjoint with: Restriction
  on property: part of
  some values from: occurrent
definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.

occurrent
type: Class
subclass of: Restriction
  on property: part of
  all values from: occurrent
disjoint with: Restriction
  on property: part of
  some values from: continuant
definition: An entity that has temporal parts and that happens, unfolds or develops through time.

independent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: independent continuant
disjoint with: specifically dependent continuant
definition: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.

process
type: Class
subclass of: occurrent
definition: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.

disposition
type: Class
subclass of: realizable entity
disjoint with: role

realizable entity
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: realizable entity
disjoint with: quality
definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.

quality
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: quality

specifically dependent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: specifically dependent continuant
definition: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.

role
type: Class
subclass of: realizable entity
definition: A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.

function
type: Class
subclass of: disposition

material entity
type: Class
subclass of: independent continuant
definition: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.

anatomical entity
type: Class
subclass of: biological entity
IAO_0000412: caro.owl

biological entity
type: Class
subclass of: independent continuant

Drosophila life
type: Class
subclass of: occurrent
definition: The life of an individual of the species Drosophila melanogaster, from fertilization to death.
has_alternative_id: FBdv_root:00000000
has_exact_synonym: Drosophila life cycle
has_obo_namespace: FlyBase_development_CV
id: FBdv:00000000

Axiom
annotated source: Drosophila life
annotated property: definition
annotated target: The life of an individual of the species Drosophila melanogaster, from fertilization to death.
database_cross_reference: FBC:DOS

cleavage stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: fertilized egg stage
definition: A collective term for stages 1-4.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00000054
comment: Temporal ordering number - 25.

Axiom
annotated source: cleavage stage
annotated property: definition
annotated target: A collective term for stages 1-4.
database_cross_reference: FBC:DOS

late extended germ band stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 10
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: early extended germ band stage
definition: A collective term for stages 11 and 12.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00004450
comment: Temporal ordering number - 300.

Axiom
annotated source: late extended germ band stage
annotated property: definition
annotated target: A collective term for stages 11 and 12.
database_cross_reference: FBC:DOS

oogenesis
type: Class
subclass of: developmental process
database_cross_reference: GO:0048477
has_exact_synonym: oogenesis stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00004886
comment: Temporal ordering number - 10000.

developmental stage
type: Class
subclass of: occurrent
definition: A temporal subdivision of a developmental process.
created by: djs93
creation date: 2009-10-01T05:56:56Z
has_alternative_id: FBdv:00007010
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005259

Axiom
annotated source: developmental stage
annotated property: definition
annotated target: A temporal subdivision of a developmental process.
database_cross_reference: FBC:DOS

oogenesis stage S1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
definition: Earliest stage of ovarian cyst development - lasts while the 16 cell cyst is within the germarium (region 3).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005261
comment: Temporal ordering number - 10010.

Axiom
annotated source: oogenesis stage S1
annotated property: definition
annotated target: Earliest stage of ovarian cyst development - lasts while the 16 cell cyst is within the germarium (region 3).
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S1
definition: Oogenesis stage that begins when the cyst leaves the germarium (from this point the cyst is referred to as an egg chamber). During this stage, polyploidation of the nurse cells begins, they reach a ploidy of 8C, and follicle cells start to divide.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005262
comment: Temporal ordering number - 10020.

Axiom
annotated source: oogenesis stage S2
annotated property: definition
annotated target: Oogenesis stage that begins when the cyst leaves the germarium (from this point the cyst is referred to as an egg chamber). During this stage, polyploidation of the nurse cells begins, they reach a ploidy of 8C, and follicle cells start to divide.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S3
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S2
definition: Oogenesis stage that begins when the oocyte chromosomes condense into a karyosome attached to a distinctive spherical structure known as an endobody. The oocyte nucleolus disappears completely. During this stage, nurse cell ploidy reaches 16C.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005263
comment: Temporal ordering number - 10030.

Axiom
annotated source: oogenesis stage S3
annotated property: definition
annotated target: Oogenesis stage that begins when the oocyte chromosomes condense into a karyosome attached to a distinctive spherical structure known as an endobody. The oocyte nucleolus disappears completely. During this stage, nurse cell ploidy reaches 16C.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S4
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S3
definition: Oogenesis stage that begins when the nurse cells chromosomes become bulbous. Nurse cell chromosomes during this stage are polytene and reach a ploidy of 32C. The egg chamber is oval shaped.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005264
comment: Temporal ordering number - 10040.

Axiom
annotated source: oogenesis stage S4
annotated property: definition
annotated target: Oogenesis stage that begins when the nurse cells chromosomes become bulbous. Nurse cell chromosomes during this stage are polytene and reach a ploidy of 32C. The egg chamber is oval shaped.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S5
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S4
definition: Oogenesis stage that begins when nurse cell chromosomes are no longer bulbous - the association between homologs weakens so that these chromosomes no longer have a polytene structure. During this stage, posterior nurse cell nuclei have a higher ploidy (64C) than anterior ones.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005265
comment: Temporal ordering number - 10050.

Axiom
annotated source: oogenesis stage S5
annotated property: definition
annotated target: Oogenesis stage that begins when nurse cell chromosomes are no longer bulbous - the association between homologs weakens so that these chromosomes no longer have a polytene structure. During this stage, posterior nurse cell nuclei have a higher ploidy (64C) than anterior ones.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S6
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S5
definition: Oogenesis stage during which follicle cell division ceases.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005266
comment: Temporal ordering number - 10060.

Axiom
annotated source: oogenesis stage S6
annotated property: definition
annotated target: Oogenesis stage during which follicle cell division ceases.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S7
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S6
definition: Oogenesis stage during which polyploidation and enlargement of follicle cells begins. Nurse cell ploidy ranges from 256C (anterior) to 512C (posterior) and the egg chamber gains an elongated shape.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005267
comment: Temporal ordering number - 10070.

Axiom
annotated source: oogenesis stage S7
annotated property: definition
annotated target: Oogenesis stage during which polyploidation and enlargement of follicle cells begins. Nurse cell ploidy ranges from 256C (anterior) to 512C (posterior) and the egg chamber gains an elongated shape.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S8
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S7
definition: Oogenesis stage which begins when yolk first appears in the oocyte. Follicle cell migration over the oocyte begins during this stage (although mostly occurs during stage 9).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005268
comment: Temporal ordering number - 10080.

Axiom
annotated source: oogenesis stage S8
annotated property: definition
annotated target: Oogenesis stage which begins when yolk first appears in the oocyte. Follicle cell migration over the oocyte begins during this stage (although mostly occurs during stage 9).
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S9
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S8
definition: Oogenesis stage that begins when the border cells begin to migrate. During this stage: the oocyte is about 1/3 the length of the egg chamber with its nucleus located antero-dorsally; follicle cell migration results in an anterior to posterior gradient of follicle cell thickness with posterior cells being thicker (-> columnar) and posterior cells thinner ( -> squamous); border cell migration begins and ends; secretion of vitelline membrane begins.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005269
comment: Temporal ordering number - 10090.

Axiom
annotated source: oogenesis stage S9
annotated property: definition
annotated target: Oogenesis stage that begins when the border cells begin to migrate. During this stage: the oocyte is about 1/3 the length of the egg chamber with its nucleus located antero-dorsally; follicle cell migration results in an anterior to posterior gradient of follicle cell thickness with posterior cells being thicker (-> columnar) and posterior cells thinner ( -> squamous); border cell migration begins and ends; secretion of vitelline membrane begins.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S10
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S9
definition: Oogenesis stage that begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends with the beginning of nurse cell dumping.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005270
comment: Temporal ordering number - 10100.

Axiom
annotated source: oogenesis stage S10
annotated property: definition
annotated target: Oogenesis stage that begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends with the beginning of nurse cell dumping.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S10A
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S10
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S9
definition: Oogenesis stage which begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends when centripetal follicle migration begins. During this stage, the migrating border cells reach the oocyte. The oocyte is about 50% egg chamber length.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005271
comment: Temporal ordering number - 10110.

Axiom
annotated source: oogenesis stage S10A
annotated property: definition
annotated target: Oogenesis stage which begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends when centripetal follicle migration begins. During this stage, the migrating border cells reach the oocyte. The oocyte is about 50% egg chamber length.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074

oogenesis stage S10B
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S10
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S10A
definition: Oogenesis stage that begins when the centripetal follicle cells begin to migrate. As a result, the vitelline membrane extends into the opercular region. This stage ends when nurse cell dumping begins.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005272
comment: Temporal ordering number - 10120.

Axiom
annotated source: oogenesis stage S10B
annotated property: definition
annotated target: Oogenesis stage that begins when the centripetal follicle cells begin to migrate. As a result, the vitelline membrane extends into the opercular region. This stage ends when nurse cell dumping begins.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S11
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S10
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S10B
definition: Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins. The dorsal appendages begin to form during this stage. This stage ends when dying nurse cells form an anterior cap to the oocyte.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005273
comment: Temporal ordering number - 10130.

Axiom
annotated source: oogenesis stage S11
annotated property: definition
annotated target: Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins. The dorsal appendages begin to form during this stage. This stage ends when dying nurse cells form an anterior cap to the oocyte.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0043885
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S12
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S11
definition: Oogenesis stage that begins when dying nurse cells form an anterior cap to the oocyte. Shortly after this, nurse cell dumping and growth of the oocyte are complete. Elongation of the dorsal appendages and formation of the innermost chorionic layer and endochorion begins during this stage.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005274
comment: Temporal ordering number - 10160.

Axiom
annotated source: oogenesis stage S12
annotated property: definition
annotated target: Oogenesis stage that begins when dying nurse cells form an anterior cap to the oocyte. Shortly after this, nurse cell dumping and growth of the oocyte are complete. Elongation of the dorsal appendages and formation of the innermost chorionic layer and endochorion begins during this stage.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0043885
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S12A
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S12
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S11
definition: Innermost chorionic layer and endochorion begin to form in the anterior of the follicle.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005275
comment: Temporal ordering number - 10170.

Axiom
annotated source: oogenesis stage S12A
annotated property: definition
annotated target: Innermost chorionic layer and endochorion begin to form in the anterior of the follicle.
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S12B
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S12
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S12A
definition: Secretion of innermost chorionic layer and endochorion begins in the main follicle cells.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005276
comment: Temporal ordering number - 10180.

Axiom
annotated source: oogenesis stage S12B
annotated property: definition
annotated target: Secretion of innermost chorionic layer and endochorion begins in the main follicle cells.
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S12C
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S12
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S12B
definition: Formation of specialized endochorion structures in the anterior of the follicle: branches in the developing dorsal appendages; compact endochorion lacking the pillars seen in the rest of the follicle.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005277
comment: Temporal ordering number - 10190.

Axiom
annotated source: oogenesis stage S12C
annotated property: definition
annotated target: Formation of specialized endochorion structures in the anterior of the follicle: branches in the developing dorsal appendages; compact endochorion lacking the pillars seen in the rest of the follicle.
database_cross_reference: FlyBase:FBrf0021038

oogenesis stage S13
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S12
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S12C
definition: Oogenesis stage that begins when the micropyle begins to form. At the beginning of this stage, about 12-15 nurse cell nuclei remain at the anterior of the oocyte. By the end of this stage, none of these nuclei remain. Oocyte meiosis up to arrest at full metaphase I occurs during this stage.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005278
comment: Temporal ordering number - 10200.

Axiom
annotated source: oogenesis stage S13
annotated property: definition
annotated target: Oogenesis stage that begins when the micropyle begins to form. At the beginning of this stage, about 12-15 nurse cell nuclei remain at the anterior of the oocyte. By the end of this stage, none of these nuclei remain. Oocyte meiosis up to arrest at full metaphase I occurs during this stage.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0029744
database_cross_reference: FlyBase:FBrf0034074
database_cross_reference: FlyBase:FBrf0064777

oogenesis stage S13A
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S12C
definition: Oogenesis stage during which 12-15 nurse cell nuclei remain at the anterior of the oocyte. At this stage, the oocyte nucleus has reached its maximum volume and its chromosomes are compressed into a 5-7 micrometer karyosome.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005279
comment: Temporal ordering number - 10210. An alternative division of stage 13 into two sub-stages, A and B, has been defined on the basis of chorion development (see FBrf0043885). This ontology uses an alternative subdivision based on nurse cell nucleus number and oocyte meiosis, as the former at least, is easier to score than chorion ultrastructure.

Axiom
annotated source: oogenesis stage S13A
annotated property: definition
annotated target: Oogenesis stage during which 12-15 nurse cell nuclei remain at the anterior of the oocyte. At this stage, the oocyte nucleus has reached its maximum volume and its chromosomes are compressed into a 5-7 micrometer karyosome.
database_cross_reference: FlyBase:FBrf0029744

oogenesis stage S13B
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S13A
definition: Oogenesis stage during which 9-11 nurse cell nuclei remain at the anterior of the oocyte. During this stage, the nuclear membrane of the oocyte nucleus disappears, indicating the start of meiotic pro-metaphase.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005280
comment: Temporal ordering number - 10220. An alternative division of stage 13 into two sub-stages, A and B, has been defined on the basis of chorion development (see FBrf0043885). This ontology uses an alternative subdivision based on nurse cell nucleus number and oocyte meiosis, as the former at least, is easier to score than chorion ultrastructure.

Axiom
annotated source: oogenesis stage S13B
annotated property: definition
annotated target: Oogenesis stage during which 9-11 nurse cell nuclei remain at the anterior of the oocyte. During this stage, the nuclear membrane of the oocyte nucleus disappears, indicating the start of meiotic pro-metaphase.
database_cross_reference: FlyBase:FBrf0029744

oogenesis stage S13C
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S13B
definition: Oogenesis stage during which only 7-8 nurse cell nuclei remain at the anterior of the oocyte. At the beginning of this stage, oocyte chromosome bivalents separate from each other - indicating mid-prometaphase of oocyte meiosis.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005281
comment: Temporal ordering number - 10230.

Axiom
annotated source: oogenesis stage S13C
annotated property: definition
annotated target: Oogenesis stage during which only 7-8 nurse cell nuclei remain at the anterior of the oocyte. At the beginning of this stage, oocyte chromosome bivalents separate from each other - indicating mid-prometaphase of oocyte meiosis.
database_cross_reference: FlyBase:FBrf0029744

oogenesis stage S13D
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S13C
definition: Oogenesis stage during which only 5-6 nurse cell nuclei remain at the anterior of the oocyte. The oocyte nucleus is in late prometaphase:the bivalents arrange themselves in on the equatorial plane of the spindle; homologous centromeres are pulled towards the poles.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005282
comment: Temporal ordering number - 10240.

Axiom
annotated source: oogenesis stage S13D
annotated property: definition
annotated target: Oogenesis stage during which only 5-6 nurse cell nuclei remain at the anterior of the oocyte. The oocyte nucleus is in late prometaphase:the bivalents arrange themselves in on the equatorial plane of the spindle; homologous centromeres are pulled towards the poles.
database_cross_reference: FlyBase:FBrf0029744

oogenesis stage S14
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S13
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S13D
definition: The last stage of oogenesis. This stage begins when no nurse cell nuclei remain at the anterior of the egg (chamber). Exochorion formation and secretion occurs during this stage. The dorsal appendages complete their elongation and the follicle cells die.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005283
comment: Temporal ordering number - 10260.

Axiom
annotated source: oogenesis stage S14
annotated property: definition
annotated target: The last stage of oogenesis. This stage begins when no nurse cell nuclei remain at the anterior of the egg (chamber). Exochorion formation and secretion occurs during this stage. The dorsal appendages complete their elongation and the follicle cells die.
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S14A
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S14
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S13D
definition: Secretion and formation of the outer endochorionic network by throughout the follicle. Crystallization of the innermost chorionic layer of the main body follicle cells.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005284
comment: Temporal ordering number - 10270.

Axiom
annotated source: oogenesis stage S14A
annotated property: definition
annotated target: Secretion and formation of the outer endochorionic network by throughout the follicle. Crystallization of the innermost chorionic layer of the main body follicle cells.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S14B
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S14
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S14A
definition: Secretion of the exochorion begins and ends.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005285
comment: Temporal ordering number - 10280.

Axiom
annotated source: oogenesis stage S14B
annotated property: definition
annotated target: Secretion of the exochorion begins and ends.
database_cross_reference: FlyBase:FBrf0021038
database_cross_reference: FlyBase:FBrf0043885

egg stage
type: Class
subclass of: developmental stage
definition: The stage of the Drosophila life-cycle from maturation of an egg to the end of fertilization. At the beginning of this stage, the nucleus is arrested in meiotic metaphase I. The completion of meiosis and the start of protein synthesis are triggered by ovulation. If the female has already mated, fertilization begins during meiosis.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005286
comment: Temporal ordering number - 10290.

Axiom
annotated source: egg stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from maturation of an egg to the end of fertilization. At the beginning of this stage, the nucleus is arrested in meiotic metaphase I. The completion of meiosis and the start of protein synthesis are triggered by ovulation. If the female has already mated, fertilization begins during meiosis.
database_cross_reference: FlyBase:FBrf0064779

unfertilized egg stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: egg stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S14
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: oogenesis stage S14B
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005287
comment: Temporal ordering number - 10300.

fertilized egg stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: egg stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: unfertilized egg stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005288
comment: Temporal ordering number - 10.

embryonic stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: unfertilized egg stage
definition: The stage of the Drosophila life-cycle from fertilization to hatching.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005289
comment: Temporal ordering number - 20.

Axiom
annotated source: embryonic stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from fertilization to hatching.
database_cross_reference: FBC:DOS

pre-blastoderm stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: cleavage stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: fertilized egg stage
definition: Embryonic stage 1-3.
has_exact_synonym: pre-blastoderm
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005290
comment: Temporal ordering number - 30.

Axiom
annotated source: pre-blastoderm stage
annotated property: definition
annotated target: Embryonic stage 1-3.
database_cross_reference: FBC:DOS

embryonic stage 1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: fertilized egg stage
definition: The embryonic stage that lasts from the end of fertilization to the end of the second nuclear division. Duration at 25 degrees C: approximately 25 minutes (0-25 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005291
comment: Temporal ordering number - 40.

Axiom
annotated source: embryonic stage 1
annotated property: definition
annotated target: The embryonic stage that lasts from the end of fertilization to the end of the second nuclear division. Duration at 25 degrees C: approximately 25 minutes (0-25 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0064779
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 1
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 1
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: fertilized egg stage
definition: The first mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005292
comment: Temporal ordering number - 50.

Axiom
annotated source: embryonic cycle 1
annotated property: definition
annotated target: The first mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic stage 2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 1
definition: Nuclear divisions 3-8. The egg cytoplasm contracts producing a clear separation from the vitelline membrane and empty spaces at the anterior and posterior. The cleavage nuclei migrate towards the periphery. Duration at 25 degrees C approximately 40 minutes (25-65 minutes AEL).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005293
comment: Temporal ordering number - 70.

Axiom
annotated source: embryonic stage 2
annotated property: definition
annotated target: Nuclear divisions 3-8. The egg cytoplasm contracts producing a clear separation from the vitelline membrane and empty spaces at the anterior and posterior. The cleavage nuclei migrate towards the periphery. Duration at 25 degrees C approximately 40 minutes (25-65 minutes AEL).
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 2
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 1
definition: The second mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005294
comment: Temporal ordering number - 60.

Axiom
annotated source: embryonic cycle 2
annotated property: definition
annotated target: The second mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 3
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 1
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 2
definition: The third mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005295
comment: Temporal ordering number - 80.

Axiom
annotated source: embryonic cycle 3
annotated property: definition
annotated target: The third mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 4
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 3
definition: The fourth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005296
comment: Temporal ordering number - 90.

Axiom
annotated source: embryonic cycle 4
annotated property: definition
annotated target: The fourth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 5
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 4
definition: The fifth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005297
comment: Temporal ordering number - 100.

Axiom
annotated source: embryonic cycle 5
annotated property: definition
annotated target: The fifth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 6
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 5
definition: The sixth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005298
comment: Temporal ordering number - 110.

Axiom
annotated source: embryonic cycle 6
annotated property: definition
annotated target: The sixth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 7
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 6
definition: The seventh mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005299
comment: Temporal ordering number - 120.

Axiom
annotated source: embryonic cycle 7
annotated property: definition
annotated target: The seventh mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 8
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 7
definition: The eighth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005300
comment: Temporal ordering number - 130.

Axiom
annotated source: embryonic cycle 8
annotated property: definition
annotated target: The eighth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic stage 3
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 8
definition: Nuclear division 9. The cleavage nuclei complete their migration to the periphery. Polar buds form at the posterior pole and divide once. Duration at 25 degrees C: approximately 15 minutes (65-80 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005301
comment: Temporal ordering number - 140.

Axiom
annotated source: embryonic stage 3
annotated property: definition
annotated target: Nuclear division 9. The cleavage nuclei complete their migration to the periphery. Polar buds form at the posterior pole and divide once. Duration at 25 degrees C: approximately 15 minutes (65-80 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 9
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 3
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 8
definition: The ninth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005302
comment: Temporal ordering number - 150.

Axiom
annotated source: embryonic cycle 9
annotated property: definition
annotated target: The ninth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 10
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 4
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 3
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 9
definition: The tenth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005303
comment: Temporal ordering number - 180.

Axiom
annotated source: embryonic cycle 10
annotated property: definition
annotated target: The tenth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

blastoderm stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 3
definition: Embryonic stages 4 and 5.
has_exact_synonym: blastoderm
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005304
comment: Temporal ordering number - 160.

Axiom
annotated source: blastoderm stage
annotated property: definition
annotated target: Embryonic stages 4 and 5.
database_cross_reference: FBC:DOS

obsolete syncytial blastoderm stage
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005305
deprecated: true

embryonic stage 4
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pre-blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 3
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 9
definition: Nuclear division 10-13. Polar buds divide twice and become tightly grouped at the posterior pole by the end of this stage. Nuclei visible at the rim of the embryo. Stage 4 ends with the beginning of cellularization. Duration at 25 degrees C: approximately 50 minutes (80-130 minutes after egg laying).
has_exact_synonym: syncytial blastoderm
has_exact_synonym: syncytial blastoderm stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005306
comment: Temporal ordering number - 170.

Axiom
annotated source: embryonic stage 4
annotated property: definition
annotated target: Nuclear division 10-13. Polar buds divide twice and become tightly grouped at the posterior pole by the end of this stage. Nuclei visible at the rim of the embryo. Stage 4 ends with the beginning of cellularization. Duration at 25 degrees C: approximately 50 minutes (80-130 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 11
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 4
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 10
definition: The 11th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005307
comment: Temporal ordering number - 185.

Axiom
annotated source: embryonic cycle 11
annotated property: definition
annotated target: The 11th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 12
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 4
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 11
definition: The 12th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005308
comment: Temporal ordering number - 190.

Axiom
annotated source: embryonic cycle 12
annotated property: definition
annotated target: The 12th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

embryonic cycle 13
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 4
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 12
definition: The 13th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005309
comment: Temporal ordering number - 200.

Axiom
annotated source: embryonic cycle 13
annotated property: definition
annotated target: The 13th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo.
database_cross_reference: FlyBase:FBrf0049535

obsolete cellular blastoderm stage
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005310
deprecated: true

embryonic stage 5
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: cleavage stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 4
definition: Cellularization. Stage 5 begins when cellularization starts. Near the end of this stage the pole cells begin to migrate dorsally and ventral midline cells acquire an irregular, wavy appearance. Stage 5 ends when ventral furrow formation becomes apparent. Duration at 25 degrees: approximately 40 minutes (130-170 minutes after egg laying).
has_exact_synonym: cellular blastoderm
has_exact_synonym: cellular blastoderm stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005311
comment: Temporal ordering number - 210.

Axiom
annotated source: embryonic stage 5
annotated property: definition
annotated target: Cellularization. Stage 5 begins when cellularization starts. Near the end of this stage the pole cells begin to migrate dorsally and ventral midline cells acquire an irregular, wavy appearance. Stage 5 ends when ventral furrow formation becomes apparent. Duration at 25 degrees: approximately 40 minutes (130-170 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 14
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
definition: The 14th mitotic cell cycle of embryogenesis. This is the first round of nuclear division to occur in a cellularized embryo, so this is the first round of cell division. Embryonic cycle 14 mitosis is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
has_exact_synonym: first blastoderm mitosis
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005312
comment: Temporal ordering number - 255. The asynchronous nature of cycle 14 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.

Axiom
annotated source: embryonic cycle 14
annotated property: definition
annotated target: The 14th mitotic cell cycle of embryogenesis. This is the first round of nuclear division to occur in a cellularized embryo, so this is the first round of cell division. Embryonic cycle 14 mitosis is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
database_cross_reference: FlyBase:FBrf0049535
database_cross_reference: FlyBase:FBrf0089570

Axiom
annotated source: embryonic cycle 14
annotated property: has_exact_synonym
annotated target: first blastoderm mitosis
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 14A
type: Class
subclass of: embryonic cycle interphase
subclass of: Restriction
  on property: substage_of
  some values from: embryonic cycle 14
definition: The interphase of embryonic cycle 14. This begins at the same time as cellularization and is of variable length depending on cell identity: embryonic cycle 14 M phase (14B) is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
has_exact_synonym: embryonic cycle 14 interphase
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005313
comment: Temporal ordering number - 256.

Axiom
annotated source: embryonic cycle 14A
annotated property: definition
annotated target: The interphase of embryonic cycle 14. This begins at the same time as cellularization and is of variable length depending on cell identity: embryonic cycle 14 M phase (14B) is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
database_cross_reference: [FlyBase:FBrf0039741

Axiom
annotated source: embryonic cycle 14A
annotated property: has_exact_synonym
annotated target: embryonic cycle 14 interphase
database_cross_reference: FBC:DOS

embryonic cycle 14B
type: Class
subclass of: embryonic cycle M-phase
subclass of: Restriction
  on property: substage_of
  some values from: embryonic cycle 14
definition: The M-phase of embryonic cycle 14. This is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
has_exact_synonym: embryonic cycle 14 M-phase
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005314
comment: Temporal ordering number - 257. Not to be confused with mitotic domain 14B, which is a domain of cells in the dorsal midline of the head that don't undergo a 14th division (Foe, 1989). The asynchronous nature of cycle 14 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.

Axiom
annotated source: embryonic cycle 14B
annotated property: definition
annotated target: The M-phase of embryonic cycle 14. This is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains.
database_cross_reference: FlyBase:FBrf0039741

Axiom
annotated source: embryonic cycle 14B
annotated property: has_exact_synonym
annotated target: embryonic cycle 14 M-phase
database_cross_reference: FBC:DOS

embryonic cycle 15
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 14
definition: The 15th cell cycle of embryogenesis. Asynchronous.
has_exact_synonym: second blastoderm mitosis
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005315
comment: Temporal ordering number - 285. The asynchronous nature of cycle 15 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.

Axiom
annotated source: embryonic cycle 15
annotated property: definition
annotated target: The 15th cell cycle of embryogenesis. Asynchronous.
database_cross_reference: FlyBase:FBrf0089570

Axiom
annotated source: embryonic cycle 15
annotated property: has_exact_synonym
annotated target: second blastoderm mitosis
database_cross_reference: FlyBase:FBrf0089570

embryonic cycle 16
type: Class
subclass of: embryonic cycle
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic cycle 15
definition: The 16th cell cycle division of embryogenesis. Asynchronous.
has_exact_synonym: third blastoderm mitosis
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005316
comment: Temporal ordering number - 295. The asynchronous nature of cycle 16 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.

Axiom
annotated source: embryonic cycle 16
annotated property: definition
annotated target: The 16th cell cycle division of embryogenesis. Asynchronous.
database_cross_reference: FlyBase:FBrf0089570

Axiom
annotated source: embryonic cycle 16
annotated property: has_exact_synonym
annotated target: third blastoderm mitosis
database_cross_reference: FlyBase:FBrf0089570

gastrula stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 5
definition: Stages during which gastrulation occurs. 6-8.
has_exact_synonym: gastrula
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005317
comment: Temporal ordering number - 220.

Axiom
annotated source: gastrula stage
annotated property: definition
annotated target: Stages during which gastrulation occurs. 6-8.
database_cross_reference: FBC:DOS

embryonic stage 6
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: blastoderm stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 5
definition: Stage 6 begins when the ventral furrow becomes apparent, an event which is followed rapidly by the formation of the cephalic furrow. Stage 6 ends when the pole cells have adopted a dorsal (horizontal) position at the posterior. Duration at 25 degrees C: approximately 10 minutes (170-180 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005318
comment: Temporal ordering number - 230.

Axiom
annotated source: embryonic stage 6
annotated property: definition
annotated target: Stage 6 begins when the ventral furrow becomes apparent, an event which is followed rapidly by the formation of the cephalic furrow. Stage 6 ends when the pole cells have adopted a dorsal (horizontal) position at the posterior. Duration at 25 degrees C: approximately 10 minutes (170-180 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 7
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 6
definition: Stage 7 begins when the pole cells have adopted a dorsal (horizontal) position at the posterior. Invagination of the anterior and posterior midgut and hindgut follows. The 'discoid plate' that carries the pole cells forms a pocket. Transverse furrows (dorsal folds) form on the dorsal surface. This stage ends when the anterior wall of the amnioproctodeal invagination starts moving anteriorly and the pole cells are no longer visible externally. Duration at 25 degrees C: approximately 10 minutes (180-190 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005319
comment: Temporal ordering number - 240.

Axiom
annotated source: embryonic stage 7
annotated property: definition
annotated target: Stage 7 begins when the pole cells have adopted a dorsal (horizontal) position at the posterior. Invagination of the anterior and posterior midgut and hindgut follows. The 'discoid plate' that carries the pole cells forms a pocket. Transverse furrows (dorsal folds) form on the dorsal surface. This stage ends when the anterior wall of the amnioproctodeal invagination starts moving anteriorly and the pole cells are no longer visible externally. Duration at 25 degrees C: approximately 10 minutes (180-190 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

obsolete germ band stage
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005320
deprecated: true

extended germ band stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 8
definition: Stages during which the germ band is extended - 9-12.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005321
comment: Temporal ordering number - 260.

Axiom
annotated source: extended germ band stage
annotated property: definition
annotated target: Stages during which the germ band is extended - 9-12.
database_cross_reference: FBC:DOS

embryonic stage 8
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 7
definition: Stage 8 starts with the rapid phase of germ band extension and ends with the beginning of mesodermal segmentation. By the end of this stage germ band extension has progressed to the point where the proctodeal opening is at about 60% egg length and the dorsal folds (transverse furrows) are no longer visible. Duration at 25 degrees C: approximately 30 minutes (190-220 minutes after egg laying).
has_exact_synonym: rapidly extending germ band stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005322
comment: Temporal ordering number - 250.

Axiom
annotated source: embryonic stage 8
annotated property: definition
annotated target: Stage 8 starts with the rapid phase of germ band extension and ends with the beginning of mesodermal segmentation. By the end of this stage germ band extension has progressed to the point where the proctodeal opening is at about 60% egg length and the dorsal folds (transverse furrows) are no longer visible. Duration at 25 degrees C: approximately 30 minutes (190-220 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 9
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: early extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 8
definition: Stage 9 begins when mesodermal segmentation becomes (transiently) visible, and ends with the appearance of the stomodeal invagination slightly ventral to the anterior pole. Duration at 25 degrees C: approximately 40 minutes (220-260 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005323
comment: Temporal ordering number - 280.

Axiom
annotated source: embryonic stage 9
annotated property: definition
annotated target: Stage 9 begins when mesodermal segmentation becomes (transiently) visible, and ends with the appearance of the stomodeal invagination slightly ventral to the anterior pole. Duration at 25 degrees C: approximately 40 minutes (220-260 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 10
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: early extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 9
definition: Stage 10 begins with the appearance of the stomodeal invagination, slightly ventral to the anterior pole. Periodic furrows appear in the embryonic epidermis around the middle of the stage. The germ band continues to extend, reaching its maximum extent of 75% egg length towards the end of the stage. The end of the stage is marked by the beginning of invagination of the tracheal placodes. Duration at 25 degrees : approximately 60 minutes (260-320 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005324
comment: Temporal ordering number - 290.

Axiom
annotated source: embryonic stage 10
annotated property: definition
annotated target: Stage 10 begins with the appearance of the stomodeal invagination, slightly ventral to the anterior pole. Periodic furrows appear in the embryonic epidermis around the middle of the stage. The germ band continues to extend, reaching its maximum extent of 75% egg length towards the end of the stage. The end of the stage is marked by the beginning of invagination of the tracheal placodes. Duration at 25 degrees : approximately 60 minutes (260-320 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 11
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: late extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 10
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: early extended germ band stage
definition: Stage 11 begins with the invagination of the tracheal placodes. Para-segmental furrow form and segment boundary furrows become deep folds. Within the head, gnathal protuberances become apparent. The end of this stage is signaled by the appearance of a distinct cleft at the posterior pole of the embryo, which becomes detached from the vitelline membrane. This marks the beginning of germ-band retraction. Duration at 25 degrees C: approximately 120 minutes (320-440 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005325
comment: Temporal ordering number - 310.

Axiom
annotated source: embryonic stage 11
annotated property: definition
annotated target: Stage 11 begins with the invagination of the tracheal placodes. Para-segmental furrow form and segment boundary furrows become deep folds. Within the head, gnathal protuberances become apparent. The end of this stage is signaled by the appearance of a distinct cleft at the posterior pole of the embryo, which becomes detached from the vitelline membrane. This marks the beginning of germ-band retraction. Duration at 25 degrees C: approximately 120 minutes (320-440 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

obsolete contracted germ band stage
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005326
deprecated: true

embryonic stage 12
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: late extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 11
definition: Germ band retraction. Stage 12 begins when germ-band retraction starts and ends when this process is complete so that the prospective anal plate occupies the posterior pole. During this stage the posterior and anterior midgut primordia meet and fuse and the tracheal pits fuse to form the tracheal tree. Duration at 25 degrees C: approximately 120 minutes (440-560 minutes after egg laying).
has_exact_synonym: retracting germ band stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005327
comment: Temporal ordering number - 320.

Axiom
annotated source: embryonic stage 12
annotated property: definition
annotated target: Germ band retraction. Stage 12 begins when germ-band retraction starts and ends when this process is complete so that the prospective anal plate occupies the posterior pole. During this stage the posterior and anterior midgut primordia meet and fuse and the tracheal pits fuse to form the tracheal tree. Duration at 25 degrees C: approximately 120 minutes (440-560 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 13
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: late extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 12
definition: Stage 13 begins at the completion of germ-band retraction, when the prospective anal plate occupy the posterior pole. The dorsal ridge becomes apparent externally; the clypeolabrum retracts, leaving a triangular shaped gap at the anterior pole; the labium moves to the ventral midline. This stage ends when head involution begins. Duration at 25 degrees C: Approximately 60 minutes (560-620 minutes after egg laying).
has_exact_synonym: contracted germ band stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005328
comment: Temporal ordering number - 340.

Axiom
annotated source: embryonic stage 13
annotated property: definition
annotated target: Stage 13 begins at the completion of germ-band retraction, when the prospective anal plate occupy the posterior pole. The dorsal ridge becomes apparent externally; the clypeolabrum retracts, leaving a triangular shaped gap at the anterior pole; the labium moves to the ventral midline. This stage ends when head involution begins. Duration at 25 degrees C: Approximately 60 minutes (560-620 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

obsolete head involution stage
type: Class
term replaced by: FBdv:00005330
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005329
deprecated: true

embryonic stage 14
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 13
definition: Stage 14 begins with the initiation of head involution. Closure of the midgut around the yolk and dorsal closure continue. Dorsal closure is 80% complete by the end of this stage. This stage ends with the appearance of the second midgut constriction. Duration at 25 degrees C: approximately 60 minutes (620-680 minutes after egg laying).
has_exact_synonym: head involution stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005330
comment: Temporal ordering number - 350.

Axiom
annotated source: embryonic stage 14
annotated property: definition
annotated target: Stage 14 begins with the initiation of head involution. Closure of the midgut around the yolk and dorsal closure continue. Dorsal closure is 80% complete by the end of this stage. This stage ends with the appearance of the second midgut constriction. Duration at 25 degrees C: approximately 60 minutes (620-680 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

dorsal closure stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: late extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 12
definition: A collective term for stages 13-15.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005331
comment: Temporal ordering number - 330.

Axiom
annotated source: dorsal closure stage
annotated property: definition
annotated target: A collective term for stages 13-15.
database_cross_reference: FBC:DOS

embryonic stage 15
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 14
definition: Stage 15 begins with the appearance of the second midgut constriction. During this stage the 1st and 3rd midgut constrictions form, dorsal closure is completed, and epidermal segmentation is accomplished. This stage ends when the intersegmental grooves can be distinguished at mid-dorsal level. Duration at 25 degrees C: approximately 100 minutes (680-780 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005332
comment: Temporal ordering number - 360.

Axiom
annotated source: embryonic stage 15
annotated property: definition
annotated target: Stage 15 begins with the appearance of the second midgut constriction. During this stage the 1st and 3rd midgut constrictions form, dorsal closure is completed, and epidermal segmentation is accomplished. This stage ends when the intersegmental grooves can be distinguished at mid-dorsal level. Duration at 25 degrees C: approximately 100 minutes (680-780 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

late embryonic stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 15
definition: Embryonic stages 16-17.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005333
comment: Temporal ordering number - 370.

Axiom
annotated source: late embryonic stage
annotated property: definition
annotated target: Embryonic stages 16-17.
database_cross_reference: FBC:DOS

embryonic stage 16
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: late embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: dorsal closure stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 15
definition: Stage 16 begins when the intersegmental grooves can be distinguished at mid-dorsal level, and ends when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. During this stage the ventral cord retracts to about 60% egg length. Duration at 25 degrees C: approximately 180 minutes (780-960 minutes after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005334
comment: Temporal ordering number - 380.

Axiom
annotated source: embryonic stage 16
annotated property: definition
annotated target: Stage 16 begins when the intersegmental grooves can be distinguished at mid-dorsal level, and ends when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. During this stage the ventral cord retracts to about 60% egg length. Duration at 25 degrees C: approximately 180 minutes (780-960 minutes after egg laying).
database_cross_reference: FlyBase:FBrf0089570

embryonic stage 17
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: late embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 16
definition: Stage 17 begins when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. It lasts until hatching of the embryo (approximately 24 hours after egg laying), during which time much terminal differentiation occurs, the tracheal tree fills with air, so becoming completely visible, and the ventral cord continues to retract. Duration at 25 degrees C: approximately 8 hours (16-24 hours after egg laying).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005335
comment: Temporal ordering number - 390.

Axiom
annotated source: embryonic stage 17
annotated property: definition
annotated target: Stage 17 begins when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. It lasts until hatching of the embryo (approximately 24 hours after egg laying), during which time much terminal differentiation occurs, the tracheal tree fills with air, so becoming completely visible, and the ventral cord continues to retract. Duration at 25 degrees C: approximately 8 hours (16-24 hours after egg laying).
database_cross_reference: FlyBase:FBrf0089570

larval stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 17(iv)
definition: The stage of the Drosophila life-cycle from hatching to the beginning of puparium formation.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005336
comment: Temporal ordering number - 400.

Axiom
annotated source: larval stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from hatching to the beginning of puparium formation.
database_cross_reference: FBC:DOS

first instar larval stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage_of
  some values from: larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: late embryonic stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 17(iv)
definition: The first larval instar begins at hatching and ends at the first larval molt. Anterior spiracles are not yet present; posterior spiracles have two openings each. Salivary glands are very small and all cells are uniform in size. Mouth hooks typically have one tooth. Duration at 25 degrees C: approximately 25 hours (24-49 hours after egg laying; 0-25 hours after hatching).
database_cross_reference: UBERON:8000000
has_exact_synonym: L1
has_exact_synonym: first instar larva
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005337
comment: Temporal ordering number - 410.

Axiom
annotated source: first instar larval stage
annotated property: definition
annotated target: The first larval instar begins at hatching and ends at the first larval molt. Anterior spiracles are not yet present; posterior spiracles have two openings each. Salivary glands are very small and all cells are uniform in size. Mouth hooks typically have one tooth. Duration at 25 degrees C: approximately 25 hours (24-49 hours after egg laying; 0-25 hours after hatching).
database_cross_reference: FlyBase:FBrf0007733

second instar larval stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage_of
  some values from: larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: first instar larval stage
definition: The second larval instar begins at the first larval molt and ends at the second larval molt. Larvae are actively feeding and crawling in the food. Distinct anterior spiracles are present as enlargements at the end of the tracheal trunk, but not open to the outside; posterior spiracles have three openings each, and four groups of small unbranched hairs. The salivary glands extend to the first abdominal segment, and have cells that are uniform in size. Mouth hooks typically have two or three teeth. Duration at 25 degrees C: approximately 23 hours (49-72 hours after egg laying; 25-48 hours after hatching).
database_cross_reference: UBERON:8000001
has_exact_synonym: L2
has_exact_synonym: second instar larva
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005338
comment: Temporal ordering number - 420.

Axiom
annotated source: second instar larval stage
annotated property: definition
annotated target: The second larval instar begins at the first larval molt and ends at the second larval molt. Larvae are actively feeding and crawling in the food. Distinct anterior spiracles are present as enlargements at the end of the tracheal trunk, but not open to the outside; posterior spiracles have three openings each, and four groups of small unbranched hairs. The salivary glands extend to the first abdominal segment, and have cells that are uniform in size. Mouth hooks typically have two or three teeth. Duration at 25 degrees C: approximately 23 hours (49-72 hours after egg laying; 25-48 hours after hatching).
database_cross_reference: FlyBase:FBrf0007733

third instar larval stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage_of
  some values from: larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: second instar larval stage
definition: The third larval instar begins at the second larval molt and ends at puparium formation. Anterior spiracles are open to the outside; posterior spiracles have three openings each, and four groups of large branched hairs. The salivary glands extend to the second abdominal segment, with cells larger in the posterior than in the anterior of the gland. Mouth hooks typically have 9-12 teeth. About 24 hours before pupariation (at 25 degree C), larvae stop feeding and climb away from their food. Duration at 25 degrees C: approximately 48 hours (72-120 hours after egg laying; 48-96 hours after hatching).
database_cross_reference: UBERON:8000002
has_exact_synonym: L3
has_obo_namespace: FlyBase_development_CV
has_related_synonym: third instar larva
id: FBdv:00005339
comment: Temporal ordering number - 430.

Axiom
annotated source: third instar larval stage
annotated property: definition
annotated target: The third larval instar begins at the second larval molt and ends at puparium formation. Anterior spiracles are open to the outside; posterior spiracles have three openings each, and four groups of large branched hairs. The salivary glands extend to the second abdominal segment, with cells larger in the posterior than in the anterior of the gland. Mouth hooks typically have 9-12 teeth. About 24 hours before pupariation (at 25 degree C), larvae stop feeding and climb away from their food. Duration at 25 degrees C: approximately 48 hours (72-120 hours after egg laying; 48-96 hours after hatching).
database_cross_reference: FlyBase:FBrf0007733

early third instar larval stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: second instar larval stage
definition: Third instar larva prior to the wandering stage (approximately the first 24 hours of the third instar larval stage under standard conditions at 25'C.).
created by: david
creation date: 2008-11-13T11:51:56Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005340
comment: Temporal ordering number - 440.

Axiom
annotated source: early third instar larval stage
annotated property: definition
annotated target: Third instar larva prior to the wandering stage (approximately the first 24 hours of the third instar larval stage under standard conditions at 25'C.).
database_cross_reference: FlyBase:FBrf0049147

wandering third instar larval stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: late third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: early third instar larval stage
definition: Stage of the third larval instar during which the larva wanders out of the food and climbs. Under optimum conditions at 25'C, this occurs approximately 24 hours after the start of the third instar larval stage.
created by: david
creation date: 2008-11-13T11:55:46Z
has_broad_synonym: late third instar
has_broad_synonym: post-feeding larva
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005341
comment: Temporal ordering number - 460.

Axiom
annotated source: wandering third instar larval stage
annotated property: definition
annotated target: Stage of the third larval instar during which the larva wanders out of the food and climbs. Under optimum conditions at 25'C, this occurs approximately 24 hours after the start of the third instar larval stage.
database_cross_reference: FlyBase:FBrf0049147

prepupal stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage_of
  some values from: P-stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar larval stage L2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: late third instar larval stage
definition: The prepupal stage begins at puparium formation and ends when larval/pupal apolysis is complete, as indicated by the completion of imaginal head sac eversion and the expulsion of the oral armature of the larva. Duration at 25 degrees C: approximately 12 hours. (120-132.2 hours after egg laying; 0-12.2 hours after puparium formation).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005342
comment: Temporal ordering number - 500.

Axiom
annotated source: prepupal stage
annotated property: definition
annotated target: The prepupal stage begins at puparium formation and ends when larval/pupal apolysis is complete, as indicated by the completion of imaginal head sac eversion and the expulsion of the oral armature of the larva. Duration at 25 degrees C: approximately 12 hours. (120-132.2 hours after egg laying; 0-12.2 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

prepupal stage P1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar larval stage L2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: late third instar larval stage
definition: Extends from puparium formation through tanning of the pupal cuticle. Posterior spiracles and ridge between anterior spiracles tan orange. Wriggling stops completely. Puparium becomes brown to the unaided eye. Duration at 25 degrees C: approximately 20 minutes. (120-120.3 hours after egg laying; 0-0.3 hours after puparium formation).
has_exact_synonym: pupal stage P1
has_exact_synonym: puparium formation
has_exact_synonym: white puparium stage
has_narrow_synonym: pupal stage P0
has_narrow_synonym: white prepupa
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005343
comment: Temporal ordering number - 510.

Axiom
annotated source: prepupal stage P1
annotated property: definition
annotated target: Extends from puparium formation through tanning of the pupal cuticle. Posterior spiracles and ridge between anterior spiracles tan orange. Wriggling stops completely. Puparium becomes brown to the unaided eye. Duration at 25 degrees C: approximately 20 minutes. (120-120.3 hours after egg laying; 0-0.3 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P1
annotated property: has_exact_synonym
annotated target: puparium formation
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: prepupal stage P1
annotated property: has_exact_synonym
annotated target: white puparium stage
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: prepupal stage P1
annotated property: has_narrow_synonym
annotated target: pupal stage P0
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: prepupal stage P1
annotated property: has_narrow_synonym
annotated target: white prepupa
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P1
definition: Male gonads become less distinct. Oral armature stops moving permanently. Dorsal medial abdominal contractions stop. Gas bubble becomes visible within abdomen. Duration at 25 degrees C: approximately 100 minutes. (120.3-122 hours after egg laying; 0.3-2 hours after puparium formation).
has_exact_synonym: brown puparium stage
has_exact_synonym: pupal stage P2
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005344
comment: Temporal ordering number - 520.

Axiom
annotated source: prepupal stage P2
annotated property: definition
annotated target: Male gonads become less distinct. Oral armature stops moving permanently. Dorsal medial abdominal contractions stop. Gas bubble becomes visible within abdomen. Duration at 25 degrees C: approximately 100 minutes. (120.3-122 hours after egg laying; 0.3-2 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P2
annotated property: has_exact_synonym
annotated target: brown puparium stage
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P3
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P2
definition: Ridge of the operculum becomes distinct. Puparium begins to separate from underlying epidermis. Becomes positively buoyant. Duration at 25 degrees C: approximately 4 hours, 45 minutes. (122-126.75 hours after egg laying; 2-6.75 hours after puparium formation).
has_exact_synonym: bubble prepupa stage
has_exact_synonym: pupal stage P3
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005345
comment: Temporal ordering number - 530.

Axiom
annotated source: prepupal stage P3
annotated property: definition
annotated target: Ridge of the operculum becomes distinct. Puparium begins to separate from underlying epidermis. Becomes positively buoyant. Duration at 25 degrees C: approximately 4 hours, 45 minutes. (122-126.75 hours after egg laying; 2-6.75 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P3
annotated property: has_exact_synonym
annotated target: bubble prepupa stage
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P4
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P3
definition: Prepupal stage P4 begins as the lateral trunk trachea become obscured and ends when the imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 5 hours, 30 minutes. (126.75-132.2 hours after egg laying; 6.75-12.2 hours after puparium formation).
has_exact_synonym: cryptocephalic pupa
has_exact_synonym: pupal stage P4
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005346
comment: Temporal ordering number - 540.

Axiom
annotated source: prepupal stage P4
annotated property: definition
annotated target: Prepupal stage P4 begins as the lateral trunk trachea become obscured and ends when the imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 5 hours, 30 minutes. (126.75-132.2 hours after egg laying; 6.75-12.2 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P4
annotated property: has_exact_synonym
annotated target: cryptocephalic pupa
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P4(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: prepupal stage P4
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P3
definition: Lateral trunk tracheae become obscured. Dorsal medial abdominal contractions occur. Everted leg and wing discs become visible. Bubble appears in posterior of puparium, displacing the pupa anteriorly; abdominal bubble disappears. Duration at 25 degrees C: approximately 5 hours, 15 minutes. (126.75-132 hours after egg laying; 6.75-12 hours after puparium formation).
has_exact_synonym: buoyant stage
has_exact_synonym: pupal stage P4(i)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005347
comment: Temporal ordering number - 550.

Axiom
annotated source: prepupal stage P4(i)
annotated property: definition
annotated target: Lateral trunk tracheae become obscured. Dorsal medial abdominal contractions occur. Everted leg and wing discs become visible. Bubble appears in posterior of puparium, displacing the pupa anteriorly; abdominal bubble disappears. Duration at 25 degrees C: approximately 5 hours, 15 minutes. (126.75-132 hours after egg laying; 6.75-12 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P4(i)
annotated property: has_exact_synonym
annotated target: buoyant stage
database_cross_reference: FlyBase:FBrf0036849

prepupal stage P4(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: prepupal stage P4
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P4(i)
definition: Bubble is displaced to anterior end of the puparium, and pupa withdraws to the posterior end. Imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 12 minutes. (132-132.2 hours after egg laying; 12-12.2 hours after puparium formation).
has_exact_synonym: moving bubble stage
has_exact_synonym: pupal stage P4(ii)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005348
comment: Temporal ordering number - 560.

Axiom
annotated source: prepupal stage P4(ii)
annotated property: definition
annotated target: Bubble is displaced to anterior end of the puparium, and pupa withdraws to the posterior end. Imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 12 minutes. (132-132.2 hours after egg laying; 12-12.2 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: prepupal stage P4(ii)
annotated property: has_exact_synonym
annotated target: moving bubble stage
database_cross_reference: FlyBase:FBrf0036849

pupal stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage_of
  some values from: P-stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage
definition: The pupal stage starts once larval/pupal apolysis is complete as indicated by the expulsion of the larval armature. Early in this stage, the legs and wings reach full extension along the abdomen. The stage ends when the pupal cuticle separates from the underlying epidermis (pupal/adult apolysis), and the eye cup becomes yellow at its periphery. Duration at 25 degrees C: approximately 32 hours. (132.2-164.3 hours after egg laying; 12.2-44.3 hours after puparium formation).
has_exact_synonym: phanerocephalic pupa
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005349
comment: Temporal ordering number - 570. DISAMBIGUATION: In Drosophila lab vernacular, the term 'pupal stage' is often used to refer to the entire period from formation of the puparium to eclosion. However, this does not correspond to the standard usage of 'pupal stage' for Cyclorrhaphous flies (for discussion see: FBrf0087128). Briefly: formation of the puparium (hardening of the larval cuticle) marks the beginning of the pre-pupal stage. The pupal stage begins following pupal/larval apolysis - detachment of the larval epidermis from the puparium. In Drosophila, the outward sign of the completion of apolysis is the eversion of the head and expulsion of the larval mouthparts (FBrf0036849). We use P-stage to refer to the stage from pupariation to eclosion, and restrict pupal stage to its standard usage.

Axiom
annotated source: pupal stage
annotated property: definition
annotated target: The pupal stage starts once larval/pupal apolysis is complete as indicated by the expulsion of the larval armature. Early in this stage, the legs and wings reach full extension along the abdomen. The stage ends when the pupal cuticle separates from the underlying epidermis (pupal/adult apolysis), and the eye cup becomes yellow at its periphery. Duration at 25 degrees C: approximately 32 hours. (132.2-164.3 hours after egg laying; 12.2-44.3 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage
annotated property: has_exact_synonym
annotated target: phanerocephalic pupa
database_cross_reference: FlyBase:FBrf0036849

pupal stage P5
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P4
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P4(ii)
definition: Pupal stage P5 starts when the legs and wings reach full extension along the abdomen and ends as the Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 6 hours, 30 minutes. (132.2-138.7 hours after egg laying; 12.2-18.7 hours after puparium formation).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005350
comment: Temporal ordering number - 580.

Axiom
annotated source: pupal stage P5
annotated property: definition
annotated target: Pupal stage P5 starts when the legs and wings reach full extension along the abdomen and ends as the Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 6 hours, 30 minutes. (132.2-138.7 hours after egg laying; 12.2-18.7 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

pupal stage P5(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pupal stage P5
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P4
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: prepupal stage P4(ii)
definition: Legs and wings reach full extension along abdomen. Enlarged initial segments of anterior pair Malpighian tubules move from thorax into abdomen. Translucent patch that lacks adhering fat body cells becomes discernible in the middle of the eye region. Pair of white Malpighian tubules becomes visible dorsally in the abdomen. Duration at 25 degrees C: approximately 66 minutes. (132.2-133.3 hours after egg laying; 12.2-13.3 hours after puparium formation).
has_exact_synonym: Malpighian tubules migrating
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005351
comment: Temporal ordering number - 590.

Axiom
annotated source: pupal stage P5(i)
annotated property: definition
annotated target: Legs and wings reach full extension along abdomen. Enlarged initial segments of anterior pair Malpighian tubules move from thorax into abdomen. Translucent patch that lacks adhering fat body cells becomes discernible in the middle of the eye region. Pair of white Malpighian tubules becomes visible dorsally in the abdomen. Duration at 25 degrees C: approximately 66 minutes. (132.2-133.3 hours after egg laying; 12.2-13.3 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage P5(i)
annotated property: has_exact_synonym
annotated target: Malpighian tubules migrating
database_cross_reference: FlyBase:FBrf0036849

pupal stage P5(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pupal stage P5
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pupal stage P5(i)
definition: Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 5 hours, 25 minutes. (133.3-138.7 hours after egg laying; 13.3-18.7 hours after puparium formation).
has_exact_synonym: white Malpighian tubules stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005352
comment: Temporal ordering number - 600.

Axiom
annotated source: pupal stage P5(ii)
annotated property: definition
annotated target: Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 5 hours, 25 minutes. (133.3-138.7 hours after egg laying; 13.3-18.7 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage P5(ii)
annotated property: has_exact_synonym
annotated target: white Malpighian tubules stage
database_cross_reference: FlyBase:FBrf0036849

pupal stage P6
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pupal stage P5
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pupal stage P5(ii)
definition: Dark green 'yellow body' appears between the anterior ends of the two Malpighian tubule segments, mid-dorsally at the anterior of the abdomen. Duration at 25 degrees C: approximately 13 hours, 45 minutes. (138.7-152.4 hours after egg laying; 18.7-32.4 hours after puparium formation).
has_exact_synonym: green Malpighian tubules stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005353
comment: Temporal ordering number - 610.

Axiom
annotated source: pupal stage P6
annotated property: definition
annotated target: Dark green 'yellow body' appears between the anterior ends of the two Malpighian tubule segments, mid-dorsally at the anterior of the abdomen. Duration at 25 degrees C: approximately 13 hours, 45 minutes. (138.7-152.4 hours after egg laying; 18.7-32.4 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage P6
annotated property: has_exact_synonym
annotated target: green Malpighian tubules stage
database_cross_reference: FlyBase:FBrf0036849

pupal stage P7
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pupal stage P6
definition: The 'yellow body' moves back between the Malpighian tubules. The transparent pupal cuticle separates from the underlying epidermis. Eye cup becomes yellow at its perimeter. Duration at 25 degrees C: approximately 12 hours. (152.4-164.3 hours after egg laying; 32.4-44.3 hours after puparium formation).
has_exact_synonym: yellow body stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005354
comment: Temporal ordering number - 620.

Axiom
annotated source: pupal stage P7
annotated property: definition
annotated target: The 'yellow body' moves back between the Malpighian tubules. The transparent pupal cuticle separates from the underlying epidermis. Eye cup becomes yellow at its perimeter. Duration at 25 degrees C: approximately 12 hours. (152.4-164.3 hours after egg laying; 32.4-44.3 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pupal stage P7
annotated property: has_exact_synonym
annotated target: yellow body stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P8
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pupal stage P7
definition: Pale yellow pigmentation spreads inwards across the eye. Eye color becomes bright yellow, then changes to amber. Duration at 25 degrees C: approximately 12 hours 20 minutes. (164.3-176.6 hours after egg laying; 44.3-56.6 hours after puparium formation).
has_exact_synonym: pupal stage P8
has_exact_synonym: yellow-eyed stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005355
comment: Temporal ordering number - 630.

Axiom
annotated source: pharate adult stage P8
annotated property: definition
annotated target: Pale yellow pigmentation spreads inwards across the eye. Eye color becomes bright yellow, then changes to amber. Duration at 25 degrees C: approximately 12 hours 20 minutes. (164.3-176.6 hours after egg laying; 44.3-56.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P8
annotated property: has_exact_synonym
annotated target: yellow-eyed stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P9
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P8
definition: Eye color darkens to deep amber, then becomes pale pink. Duration at 25 degrees C: approximately 18 hours. (176.6-194.5 hours after egg laying; 56.6-74.5 hours after puparium formation).
has_exact_synonym: amber-eyed stage
has_exact_synonym: pupal stage P9
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005356
comment: Temporal ordering number - 640.

Axiom
annotated source: pharate adult stage P9
annotated property: definition
annotated target: Eye color darkens to deep amber, then becomes pale pink. Duration at 25 degrees C: approximately 18 hours. (176.6-194.5 hours after egg laying; 56.6-74.5 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P9
annotated property: has_exact_synonym
annotated target: amber-eyed stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P10
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P9
definition: Eyes become bright red. Orbital and ocellar bristles and vibrissae darken. Duration at 25 degrees C: approximately 6 minutes. (194.5-194.6 hours after egg laying; 74.5-74.6 hours after puparium formation).
has_exact_synonym: pupal stage P10
has_exact_synonym: red-eye bald stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005357
comment: Temporal ordering number - 650.

Axiom
annotated source: pharate adult stage P10
annotated property: definition
annotated target: Eyes become bright red. Orbital and ocellar bristles and vibrissae darken. Duration at 25 degrees C: approximately 6 minutes. (194.5-194.6 hours after egg laying; 74.5-74.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P10
annotated property: has_exact_synonym
annotated target: red-eye bald stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P11
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P10
definition: Thoracic bristles become visible, and the tips of the wings turn grey. Duration at 25 degrees C: approximately 2 hours. (194.6-196.6 hours after egg laying; 74.6-76.6 hours after puparium formation).
has_exact_synonym: pupal stage P11
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005358
comment: Temporal ordering number - 660.

Axiom
annotated source: pharate adult stage P11
annotated property: definition
annotated target: Thoracic bristles become visible, and the tips of the wings turn grey. Duration at 25 degrees C: approximately 2 hours. (194.6-196.6 hours after egg laying; 74.6-76.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

pharate adult stage P11(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage P11
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P10
definition: Dorsal thoracic microchaetes and macrochaetes become visible. Duration at 25 degrees C: approximately 80 minutes (194.6-195.5 hours after egg laying; 74.6-75.9 hours after puparium formation).
has_exact_synonym: head bristles stage
has_exact_synonym: pupal stage P11(i)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005359
comment: Temporal ordering number - 670.

Axiom
annotated source: pharate adult stage P11(i)
annotated property: definition
annotated target: Dorsal thoracic microchaetes and macrochaetes become visible. Duration at 25 degrees C: approximately 80 minutes (194.6-195.5 hours after egg laying; 74.6-75.9 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P11(i)
annotated property: has_exact_synonym
annotated target: head bristles stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P11(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage P11
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P11(i)
definition: Tips of folded wings become grey. Duration at 25 degrees C: approximately 45 minutes (195.5-196.6 hours after egg laying; 75.9-76.6 hours after puparium formation).
has_exact_synonym: pupal stage P11(ii)
has_exact_synonym: thoracic bristles stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005360
comment: Temporal ordering number - 680.

Axiom
annotated source: pharate adult stage P11(ii)
annotated property: definition
annotated target: Tips of folded wings become grey. Duration at 25 degrees C: approximately 45 minutes (195.5-196.6 hours after egg laying; 75.9-76.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P11(ii)
annotated property: has_exact_synonym
annotated target: thoracic bristles stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P12
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P11
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P11(ii)
definition: Pharate adult stage P12 begins as the abdominal tergite bristles become visible, and ends as the wings darken to black. Duration at 25 degrees C: approximately 2 hours. (196.6-198.6 hours after egg laying; 76.6-78.6 hours after puparium formation).
has_exact_synonym: pupal stage P12
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005361
comment: Temporal ordering number - 690.

Axiom
annotated source: pharate adult stage P12
annotated property: definition
annotated target: Pharate adult stage P12 begins as the abdominal tergite bristles become visible, and ends as the wings darken to black. Duration at 25 degrees C: approximately 2 hours. (196.6-198.6 hours after egg laying; 76.6-78.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

pharate adult stage P12(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage P12
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P11
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P11(ii)
definition: Bristles of the abdominal tergites become visible, and the wings become grey. Duration at 25 degrees C: approximately 55 minutes. (196.6-197.5 hours after egg laying; 76.6-77.5 hours after puparium formation).
has_exact_synonym: pupal stage P12(i)
has_exact_synonym: wing tips grey stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005362
comment: Temporal ordering number - 700.

Axiom
annotated source: pharate adult stage P12(i)
annotated property: definition
annotated target: Bristles of the abdominal tergites become visible, and the wings become grey. Duration at 25 degrees C: approximately 55 minutes. (196.6-197.5 hours after egg laying; 76.6-77.5 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P12(i)
annotated property: has_exact_synonym
annotated target: wing tips grey stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P12(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage P12
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P12(i)
definition: Sex combs darken in males. Wings darken to black. Duration at 25 degrees C: approximately 65 minutes. (197.5-198.6 hours after egg laying; 77.5-78.6 hours after puparium formation).
has_exact_synonym: pupal stage P12(ii)
has_exact_synonym: wings grey stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005363
comment: Temporal ordering number - 710.

Axiom
annotated source: pharate adult stage P12(ii)
annotated property: definition
annotated target: Sex combs darken in males. Wings darken to black. Duration at 25 degrees C: approximately 65 minutes. (197.5-198.6 hours after egg laying; 77.5-78.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P12(ii)
annotated property: has_exact_synonym
annotated target: wings grey stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P13
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P12
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P12(ii)
definition: Tarsal bristles darken and claws become black. Duration at 25 degrees C: approximately 3 hours, 20 minutes. (198.6-201.9 hours after egg laying; 78.6-81.9 hours after puparium formation).
has_exact_synonym: pupal stage P13
has_exact_synonym: wings black stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005364
comment: Temporal ordering number - 720.

Axiom
annotated source: pharate adult stage P13
annotated property: definition
annotated target: Tarsal bristles darken and claws become black. Duration at 25 degrees C: approximately 3 hours, 20 minutes. (198.6-201.9 hours after egg laying; 78.6-81.9 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P13
annotated property: has_exact_synonym
annotated target: wings black stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P14
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P13
definition: The meconium appears dorsally at the posterior tip of the abdomen. Duration at 25 degrees C: approximately 9 hours, 30 minutes (201.9-211.5 hours after egg laying; 81.9-91.5 hours after puparium formation).
has_exact_synonym: mature bristles stage
has_exact_synonym: pupal stage P14
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005365
comment: Temporal ordering number - 730.

Axiom
annotated source: pharate adult stage P14
annotated property: definition
annotated target: The meconium appears dorsally at the posterior tip of the abdomen. Duration at 25 degrees C: approximately 9 hours, 30 minutes (201.9-211.5 hours after egg laying; 81.9-91.5 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P14
annotated property: has_exact_synonym
annotated target: mature bristles stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P15
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P14
definition: Pharate adult stage P15 begins with the tanning of the tergites and ends with eclosion. Duration at 25 degrees C: approximately 8 hours, 30 minutes. (211.5-220 hours after egg laying; 91.5-100 hours after puparium formation).
has_exact_synonym: pupal stage P15
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005366
comment: Temporal ordering number - 740.

Axiom
annotated source: pharate adult stage P15
annotated property: definition
annotated target: Pharate adult stage P15 begins with the tanning of the tergites and ends with eclosion. Duration at 25 degrees C: approximately 8 hours, 30 minutes. (211.5-220 hours after egg laying; 91.5-100 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

pharate adult stage P15(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage P15
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P14
definition: Tanning of the tergites obscures the Malpighian tubules and the 'yellow body'. Legs begin to twitch; fly is able to walk if puparium is removed prematurely. Ptilinum expands by hydrostatic pressure, opening the operculum. Duration at 25 degrees C: approximately 8 hours, 6 minutes. (211.5-219.6 hours after egg laying; 91.5-99.6 hours after puparium formation).
has_exact_synonym: meconium stage
has_exact_synonym: pupal stage P15(i)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005367
comment: Temporal ordering number - 750.

Axiom
annotated source: pharate adult stage P15(i)
annotated property: definition
annotated target: Tanning of the tergites obscures the Malpighian tubules and the 'yellow body'. Legs begin to twitch; fly is able to walk if puparium is removed prematurely. Ptilinum expands by hydrostatic pressure, opening the operculum. Duration at 25 degrees C: approximately 8 hours, 6 minutes. (211.5-219.6 hours after egg laying; 91.5-99.6 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P15(i)
annotated property: has_exact_synonym
annotated target: meconium stage
database_cross_reference: FlyBase:FBrf0036849

pharate adult stage P15(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: pharate adult stage P15
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P15(i)
definition: Stage which starts when the operculum opens and ends when eclosion is completed. Duration at 25 degrees C: approximately 24 minutes. (219.6-220 hours after egg laying; 99.6-100 hours after puparium formation).
has_exact_synonym: eclosion stage
has_exact_synonym: pupal stage P15(ii)
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005368
comment: Temporal ordering number - 760.

Axiom
annotated source: pharate adult stage P15(ii)
annotated property: definition
annotated target: Stage which starts when the operculum opens and ends when eclosion is completed. Duration at 25 degrees C: approximately 24 minutes. (219.6-220 hours after egg laying; 99.6-100 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355

Axiom
annotated source: pharate adult stage P15(ii)
annotated property: has_exact_synonym
annotated target: eclosion stage
database_cross_reference: FlyBase:FBrf0036849

adult stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P15
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P15(ii)
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: P-stage
definition: The stage of the Drosophila life-cycle from eclosion to death.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005369
comment: Temporal ordering number - 770.

Axiom
annotated source: adult stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from eclosion to death.
database_cross_reference: FBC:DOS

adult stage A1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: immature adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P15(ii)
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: P-stage
definition: Newly eclosed adult stage. Animal free of pupal case. Runs rapidly to find site for wing expansion. Wings are folded back and black against a very pale abdomen.
has_alternative_id: FBdv:00005373
has_obo_namespace: FlyBase_development_CV
has_related_synonym: adult stage I
id: FBdv:00005370
comment: Temporal ordering number - 785. The time at which eclosed flies settle down for wing expansion can vary greatly. If they fail to find a suitable site then expansion can be delayed by several hours.

Axiom
annotated source: adult stage A1
annotated property: definition
annotated target: Newly eclosed adult stage. Animal free of pupal case. Runs rapidly to find site for wing expansion. Wings are folded back and black against a very pale abdomen.
database_cross_reference: FlyBase:FBrf0049147

adult stage A2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: immature adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: adult stage A1
definition: Stage, shortly after eclosion, during which the wings expand. During wing expansion, the abdomen pulsates and the hind legs stroke the wings vigorously for several minutes at a time. The stage ends when the wings are folded down over the abdomen, which has become broader and shorter, and the wing cuticle has lost its folds. The stage lasts around 15 minutes at 25'C.
has_alternative_id: FBdv:00005374
has_obo_namespace: FlyBase_development_CV
has_related_synonym: adult stage II
id: FBdv:00005371
comment: Temporal ordering number - 790.

Axiom
annotated source: adult stage A2
annotated property: definition
annotated target: Stage, shortly after eclosion, during which the wings expand. During wing expansion, the abdomen pulsates and the hind legs stroke the wings vigorously for several minutes at a time. The stage ends when the wings are folded down over the abdomen, which has become broader and shorter, and the wing cuticle has lost its folds. The stage lasts around 15 minutes at 25'C.
database_cross_reference: FlyBase:FBrf0049147

FBdv_00005373
type: Class
IAO_0000231: IAO_0000227
term replaced by: adult stage A1
deprecated: true

FBdv_00005374
type: Class
IAO_0000231: IAO_0000227
term replaced by: adult stage A2
deprecated: true

FBdv_00005375
type: Class
IAO_0000231: IAO_0000227
term replaced by: adult stage A3
deprecated: true

gamete
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00005412
comment: This should be considered as a type of cell rather than as a stage. Please use FBbt:00005412.
deprecated: true

pharate adult stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage_of
  some values from: P-stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pupal stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pupal stage P7
definition: The developing adult after pupal-adult apolysis, i.e.- from stage P8 (when yellow eye color first becomes visible through the pupal case), to eclosion. Duration at 25 degrees C: approximately 55.7 hours (164.3-220 hours after egg laying; 44.3-100 hours after puparium formation).
has_obo_namespace: FlyBase_development_CV
id: FBdv:00006011
comment: Temporal ordering number - 625.

Axiom
annotated source: pharate adult stage
annotated property: definition
annotated target: The developing adult after pupal-adult apolysis, i.e.- from stage P8 (when yellow eye color first becomes visible through the pupal case), to eclosion. Duration at 25 degrees C: approximately 55.7 hours (164.3-220 hours after egg laying; 44.3-100 hours after puparium formation).
database_cross_reference: FlyBase:FBrf0036849
database_cross_reference: FlyBase:FBrf0048355
database_cross_reference: FlyBase:FBrf0049147

adult stage A3
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: immature adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: adult stage A2
definition: Adult stage immediately after wing expansion, during which tanning of the cuticle is completed. This stage lasts approximately 45 minutes at 25'C.
has_alternative_id: FBdv:00005375
has_obo_namespace: FlyBase_development_CV
has_related_synonym: adult stage III
id: FBdv:00006012
comment: Temporal ordering number - 800.

Axiom
annotated source: adult stage A3
annotated property: definition
annotated target: Adult stage immediately after wing expansion, during which tanning of the cuticle is completed. This stage lasts approximately 45 minutes at 25'C.
database_cross_reference: FlyBase:FBrf0049147

spermatogenesis
type: Class
subclass of: developmental process
created by: david
creation date: 2008-06-05T04:51:08Z
database_cross_reference: GO:0007283
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007000
comment: Temporal ordering number - 20000.

P-stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar larval stage L2
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: late third instar larval stage
definition: The stage of the Drosophila life-cycle from the formation of the puparium (beginning of the prepupal stage) to eclosion.
created by: david
creation date: 2008-06-05T04:51:40Z
has_broad_synonym: metamorphosis
has_obo_namespace: FlyBase_development_CV
has_related_synonym: pupal stage
id: FBdv:00007001
comment: Temporal ordering number - 490. DISAMBIGUATION: In Drosophila lab vernacular, the term 'pupal stage' is often used to refer to the entire period from formation of the puparium to eclosion. However, this does not correspond to the standard usage of 'pupal stage' for cyclorrhaphous flies (for discussion see: FBrf0087128). Briefly: formation of the puparium (hardening of the larval cuticle) marks the beginning of the pre-pupal stage. The pupal stage begins following pupal/larval apolysis - detachment of the larval epidermis from the puparium. In Drosophila, the outward sign of the completion of apolysis is the eversion of the head an expulsion of the larval mouthparts (FBrf0036849). We use P-stage to refer to the stage from pupariation to eclosion, and restrict pupal stage to its standard usage.

Axiom
annotated source: P-stage
annotated property: definition
annotated target: The stage of the Drosophila life-cycle from the formation of the puparium (beginning of the prepupal stage) to eclosion.
database_cross_reference: FBC:DOS

oogenesis stage S11a
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S11
definition: Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins and ends when the dorsal appendages begin to form.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007002
comment: Temporal ordering number - 10140.

Axiom
annotated source: oogenesis stage S11a
annotated property: definition
annotated target: Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins and ends when the dorsal appendages begin to form.
database_cross_reference: FlyBase:FBrf0043885

oogenesis stage S11b
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S11
definition: Oogenesis stage that begins when endochorion begins to form at the anterior pole, a process which includes the beginning of formation of the dorsal appendages. During this stage, the follicle cells secrete membranous vesicles that form irregular extracellular plaques. This stage ends when dying nurse cells form an anterior cap to the oocyte.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007003
comment: Temporal ordering number - 10150.

Axiom
annotated source: oogenesis stage S11b
annotated property: definition
annotated target: Oogenesis stage that begins when endochorion begins to form at the anterior pole, a process which includes the beginning of formation of the dorsal appendages. During this stage, the follicle cells secrete membranous vesicles that form irregular extracellular plaques. This stage ends when dying nurse cells form an anterior cap to the oocyte.
database_cross_reference: FlyBase:FBrf0043885

third instar larval stage L1
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: late third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: wandering third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar - cleared gut stage
definition: Stage which begins when wandering third instar larva stops crawling. The larva everts its anterior spiracles during this stage.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007004
comment: Temporal ordering number - 470.

Axiom
annotated source: third instar larval stage L1
annotated property: definition
annotated target: Stage which begins when wandering third instar larva stops crawling. The larva everts its anterior spiracles during this stage.
database_cross_reference: FlyBase:FBrf0036849

third instar larval stage L2
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: late third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar larval stage L1
definition: The anterior spiracles are fully everted, with 7-9 finger-like projections. The body shortens, withdrawing three apparent abdominal segments and the larva sticks to its substrate.
has_exact_synonym: spiracles everted larva
has_obo_namespace: FlyBase_development_CV
has_related_synonym: white prepupa
id: FBdv:00007005
comment: Temporal ordering number - 480.

Axiom
annotated source: third instar larval stage L2
annotated property: definition
annotated target: The anterior spiracles are fully everted, with 7-9 finger-like projections. The body shortens, withdrawing three apparent abdominal segments and the larva sticks to its substrate.
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: third instar larval stage L2
annotated property: has_exact_synonym
annotated target: spiracles everted larva
database_cross_reference: FlyBase:FBrf0036849

Axiom
annotated source: third instar larval stage L2
annotated property: has_related_synonym
annotated target: white prepupa
database_cross_reference: FlyBase:FBrf0036849

oogenesis stage S13E
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: oogenesis stage S13
definition: Oogenesis stage during which the number of nurse cell nuclei at the anterior of the oocyte reduce from 4 to zero. The oocyte chromosomes reach full metaphase I during this stage, at which point meiosis is arrested (until fertilization).
created by: david
creation date: 2008-11-13T06:27:57Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007006
comment: Temporal ordering number - 10250.

Axiom
annotated source: oogenesis stage S13E
annotated property: definition
annotated target: Oogenesis stage during which the number of nurse cell nuclei at the anterior of the oocyte reduce from 4 to zero. The oocyte chromosomes reach full metaphase I during this stage, at which point meiosis is arrested (until fertilization).
database_cross_reference: FlyBase:FBrf0029744

late third instar larval stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: early third instar larval stage
definition: Third instar larva from the beginning of wandering to the beginning of puparium formation.
created by: david
creation date: 2008-12-11T01:19:53Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007007
comment: Temporal ordering number - 450.

Axiom
annotated source: late third instar larval stage
annotated property: definition
annotated target: Third instar larva from the beginning of wandering to the beginning of puparium formation.
database_cross_reference: FBC:DOS

obsolete occurrent
type: Class
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007008
deprecated: true

developmental process
type: Class
subclass of: biological process
created by: djs93
creation date: 2009-10-01T05:56:42Z
database_cross_reference: GO:0032502
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007009

FBdv_00007010
type: Class
IAO_0000231: IAO_0000227
term replaced by: developmental stage
deprecated: true

embryonic cycle
type: Class
subclass of: biological process
subclass of: mitotic cell cycle, embryonic
definition: A cycle of nuclear division during the embryogenesis of Drosophila melanogaster. The first 13 cycles are synchronous throughout the embryo and occur their timing relative to other developmental processes is invariant. Later nuclear division cycles are asynchronous across the embryo although may be more locally synchronized.
created by: djs93
creation date: 2009-10-01T05:57:41Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007011

Axiom
annotated source: embryonic cycle
annotated property: definition
annotated target: A cycle of nuclear division during the embryogenesis of Drosophila melanogaster. The first 13 cycles are synchronous throughout the embryo and occur their timing relative to other developmental processes is invariant. Later nuclear division cycles are asynchronous across the embryo although may be more locally synchronized.
database_cross_reference: FlyBase:FBrf0049535
database_cross_reference: FlyBase:FBrf0089570

life stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: Drosophila life
definition: A temporal subdivision of a Drosophila life, delimited by major transitions in the circumstances of the organism, such as: fertilization; hatching; pupal ecdysis; eclosion.
created by: djs93
creation date: 2009-10-01T05:59:22Z
has_exact_synonym: life cycle stage
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007012

Axiom
annotated source: life stage
annotated property: definition
annotated target: A temporal subdivision of a Drosophila life, delimited by major transitions in the circumstances of the organism, such as: fertilization; hatching; pupal ecdysis; eclosion.
database_cross_reference: FBC:DOS

age
type: Class
subclass of: occurrent
definition: Temporal subdivision of life based on time elapsed since some key developmental transition, such as fertilization, hatching or eclosion.
created by: djs93
creation date: 2010-09-29T12:25:36Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007013

Axiom
annotated source: age
annotated property: definition
annotated target: Temporal subdivision of life based on time elapsed since some key developmental transition, such as fertilization, hatching or eclosion.
database_cross_reference: FBC:DOS

adult age in days
type: Class
subclass of: age
definition: Temporal subdivision of adulthood in days post-eclosion.
created by: djs93
creation date: 2010-09-29T12:28:05Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007014

Axiom
annotated source: adult age in days
annotated property: definition
annotated target: Temporal subdivision of adulthood in days post-eclosion.
database_cross_reference: FBC:DOS

embryonic stage 17(i)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 16
definition: The first two hours of embryonic stage 17 at 25'C. (Approximately 16-18 hours at 25'C after egg laying).
created by: djs93
creation date: 2011-04-26T11:57:15Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007015
comment: Temporal ordering number - 391. Should not be used to stage embryos whose development is at temperatures other than 25'C.

Axiom
annotated source: embryonic stage 17(i)
annotated property: definition
annotated target: The first two hours of embryonic stage 17 at 25'C. (Approximately 16-18 hours at 25'C after egg laying).
database_cross_reference: FBC:DOS

embryonic stage 17(ii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 17(i)
definition: Hours 2-4 of embryonic stage 17 at 25'C. (Approximately 18-20 hours at 25'C after egg laying).
created by: djs93
creation date: 2011-04-26T12:00:15Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007016
comment: Temporal ordering number - 392. Should not be used to stage embryos whose development is at temperatures other than 25'C.

Axiom
annotated source: embryonic stage 17(ii)
annotated property: definition
annotated target: Hours 2-4 of embryonic stage 17 at 25'C. (Approximately 18-20 hours at 25'C after egg laying).
database_cross_reference: FBC:DOS

embryonic stage 17(iii)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 17(ii)
definition: Hours 4-6 of embryonic stage 17 at 25'C. (Approximately 20-22 hours at 25'C after egg laying).
created by: djs93
creation date: 2011-04-26T12:01:18Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007017
comment: Temporal ordering number - 393. Should not be used to stage embryos whose development is at temperatures other than 25'C.

Axiom
annotated source: embryonic stage 17(iii)
annotated property: definition
annotated target: Hours 4-6 of embryonic stage 17 at 25'C. (Approximately 20-22 hours at 25'C after egg laying).
database_cross_reference: FBC:DOS

embryonic stage 17(iv)
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: embryonic stage 17
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 17(iii)
definition: Hours 6-8 (the last two hours) of embryonic stage 17 at 25'C. (Approximately 22-24 hours at 25'C after egg laying).
created by: djs93
creation date: 2011-04-26T12:03:14Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007018
comment: Temporal ordering number - 394. Should not be used to stage embryos whose development is at temperatures other than 25'C.

Axiom
annotated source: embryonic stage 17(iv)
annotated property: definition
annotated target: Hours 6-8 (the last two hours) of embryonic stage 17 at 25'C. (Approximately 22-24 hours at 25'C after egg laying).
database_cross_reference: FBC:DOS

third instar - uncleared gut stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: wandering third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: early third instar larval stage
definition: The substage of the wandering third instar larval stage, prior to the beginning of clearance of the gut.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007019
comment: Temporal ordering number - 462. This is commonly assayed by adding 0.5% bromophenol blue to the food and looking for wandering third instar larvae with the same color guts (dark blue) as feeding larvae (Andres and Thummel, 1994). Larvae at this stage are in chromosomal puff stage 1 (Andres and Thummel, 1994).

Axiom
annotated source: third instar - uncleared gut stage
annotated property: definition
annotated target: The substage of the wandering third instar larval stage, prior to the beginning of clearance of the gut.
database_cross_reference: FlyBase:FBrf0076598

third instar - partially cleared gut stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: wandering third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar - uncleared gut stage
definition: The substage of the wandering third instar larval stage when the larva has partially cleared its gut contents.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007020
comment: Temporal ordering number - 465. This is commonly assayed by adding 0.5% bromophenol blue to the food and looking for wandering third instar larvae with lighter colored guts (light blue) than feeding larvae (Andres and Thummel, 1994). Larvae at this stage are mainly in chromosomal puff stages 2-7 (Andres and Thummel, 1994).

Axiom
annotated source: third instar - partially cleared gut stage
annotated property: definition
annotated target: The substage of the wandering third instar larval stage when the larva has partially cleared its gut contents.
database_cross_reference: FlyBase:FBrf0076598

third instar - cleared gut stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: wandering third instar larval stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: third instar - partially cleared gut stage
definition: The substage of the wandering third instar larval stage when the larva has cleared its gut contents.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007021
comment: Temporal ordering number - 467. This is commonly assayed by adding 0.5% bromophenol blue to the food and looking for wandering third instar larvae with guts lacking any blue stain (Andres and Thummel, 1994). Larvae at this stage are mainly in chromosomal puff stages 7-9 and pupate within 1-6 hours (Andres and Thummel, 1994.

Axiom
annotated source: third instar - cleared gut stage
annotated property: definition
annotated target: The substage of the wandering third instar larval stage when the larva has cleared its gut contents.
database_cross_reference: FlyBase:FBrf0076598

embryonic cycle interphase
type: Class
equivalent class: Class
  intersection of: interphase
  intersection of: Restriction
    on property: substage_of
    some values from: embryonic cycle
subclass of: biological process
subclass of: mitotic interphase
subclass of: Restriction
  on property: substage_of
  some values from: embryonic cycle
definition: The interphase (GO:0051325) of an embryonic cycle.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007022

Axiom
annotated source: embryonic cycle interphase
annotated property: definition
annotated target: The interphase (GO:0051325) of an embryonic cycle.
database_cross_reference: FBC:DOS

embryonic cycle M-phase
type: Class
equivalent class: Class
  intersection of: M phase
  intersection of: Restriction
    on property: substage_of
    some values from: embryonic cycle
subclass of: biological process
subclass of: mitotic M phase
subclass of: Restriction
  on property: substage_of
  some values from: embryonic cycle
definition: The M-phase (GO:0000279) of an embryonic cycle.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007023

Axiom
annotated source: embryonic cycle M-phase
annotated property: definition
annotated target: The M-phase (GO:0000279) of an embryonic cycle.
database_cross_reference: FBC:DOS

biological process
type: Class
subclass of: occurrent
database_cross_reference: GO:0008150
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007024

immature adult stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: substage_of
  some values from: day 0 of adulthood
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: P-stage
definition: The developmental stage that lasts from eclosion of the adult from the pupal case until tanning is complete (the end of adult stage A3).
created by: djs93
creation date: 2013-01-08T20:06:59Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007025
comment: Temporal ordering number - 782.

Axiom
annotated source: immature adult stage
annotated property: definition
annotated target: The developmental stage that lasts from eclosion of the adult from the pupal case until tanning is complete (the end of adult stage A3).
database_cross_reference: FBC:DOS

mature adult stage
type: Class
subclass of: life stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: adult stage A3
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: immature adult stage
definition: Life stage from the end of adult stage A3, when tanning is complete, to death.
created by: djs93
creation date: 2013-01-10T13:03:54Z
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007026

Axiom
annotated source: mature adult stage
annotated property: definition
annotated target: Life stage from the end of adult stage A3, when tanning is complete, to death.
database_cross_reference: FBC:DOS

day 0 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P15
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage P15(ii)
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: pharate adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: P-stage
definition: The day of eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007075
comment: Temporal ordering number - 780.

Axiom
annotated source: day 0 of adulthood
annotated property: definition
annotated target: The day of eclosion.
database_cross_reference: FBC:DOS

day 1 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 0 of adulthood
definition: 1st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007076
comment: Temporal ordering number - 810.

Axiom
annotated source: day 1 of adulthood
annotated property: definition
annotated target: 1st day after eclosion.
database_cross_reference: FBC:DOS

day 2 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 1 of adulthood
definition: 2nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007077
comment: Temporal ordering number - 820.

Axiom
annotated source: day 2 of adulthood
annotated property: definition
annotated target: 2nd day after eclosion.
database_cross_reference: FBC:DOS

day 3 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 2 of adulthood
definition: 3rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007078
comment: Temporal ordering number - 830.

Axiom
annotated source: day 3 of adulthood
annotated property: definition
annotated target: 3rd day after eclosion.
database_cross_reference: FBC:DOS

day 4 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 3 of adulthood
definition: 4th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007079
comment: Temporal ordering number - 840.

Axiom
annotated source: day 4 of adulthood
annotated property: definition
annotated target: 4th day after eclosion.
database_cross_reference: FBC:DOS

day 5 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 4 of adulthood
definition: 5th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007080
comment: Temporal ordering number - 850.

Axiom
annotated source: day 5 of adulthood
annotated property: definition
annotated target: 5th day after eclosion.
database_cross_reference: FBC:DOS

day 6 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 5 of adulthood
definition: 6th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007081
comment: Temporal ordering number - 860.

Axiom
annotated source: day 6 of adulthood
annotated property: definition
annotated target: 6th day after eclosion.
database_cross_reference: FBC:DOS

day 7 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 6 of adulthood
definition: 7th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007082
comment: Temporal ordering number - 870.

Axiom
annotated source: day 7 of adulthood
annotated property: definition
annotated target: 7th day after eclosion.
database_cross_reference: FBC:DOS

day 8 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 7 of adulthood
definition: 8th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007083
comment: Temporal ordering number - 880.

Axiom
annotated source: day 8 of adulthood
annotated property: definition
annotated target: 8th day after eclosion.
database_cross_reference: FBC:DOS

day 9 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 8 of adulthood
definition: 9th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007084
comment: Temporal ordering number - 890.

Axiom
annotated source: day 9 of adulthood
annotated property: definition
annotated target: 9th day after eclosion.
database_cross_reference: FBC:DOS

day 10 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 9 of adulthood
definition: 10th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007085
comment: Temporal ordering number - 900.

Axiom
annotated source: day 10 of adulthood
annotated property: definition
annotated target: 10th day after eclosion.
database_cross_reference: FBC:DOS

day 11 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 10 of adulthood
definition: 11th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007086
comment: Temporal ordering number - 910.

Axiom
annotated source: day 11 of adulthood
annotated property: definition
annotated target: 11th day after eclosion.
database_cross_reference: FBC:DOS

day 12 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 11 of adulthood
definition: 12th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007087
comment: Temporal ordering number - 920.

Axiom
annotated source: day 12 of adulthood
annotated property: definition
annotated target: 12th day after eclosion.
database_cross_reference: FBC:DOS

day 13 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 12 of adulthood
definition: 13th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007088
comment: Temporal ordering number - 930.

Axiom
annotated source: day 13 of adulthood
annotated property: definition
annotated target: 13th day after eclosion.
database_cross_reference: FBC:DOS

day 14 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 13 of adulthood
definition: 14th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007089
comment: Temporal ordering number - 940.

Axiom
annotated source: day 14 of adulthood
annotated property: definition
annotated target: 14th day after eclosion.
database_cross_reference: FBC:DOS

day 15 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 14 of adulthood
definition: 15th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007090
comment: Temporal ordering number - 950.

Axiom
annotated source: day 15 of adulthood
annotated property: definition
annotated target: 15th day after eclosion.
database_cross_reference: FBC:DOS

day 16 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 15 of adulthood
definition: 16th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007091
comment: Temporal ordering number - 960.

Axiom
annotated source: day 16 of adulthood
annotated property: definition
annotated target: 16th day after eclosion.
database_cross_reference: FBC:DOS

day 17 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 16 of adulthood
definition: 17th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007092
comment: Temporal ordering number - 970.

Axiom
annotated source: day 17 of adulthood
annotated property: definition
annotated target: 17th day after eclosion.
database_cross_reference: FBC:DOS

day 18 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 17 of adulthood
definition: 18th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007093
comment: Temporal ordering number - 980.

Axiom
annotated source: day 18 of adulthood
annotated property: definition
annotated target: 18th day after eclosion.
database_cross_reference: FBC:DOS

day 19 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 18 of adulthood
definition: 19th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007094
comment: Temporal ordering number - 990.

Axiom
annotated source: day 19 of adulthood
annotated property: definition
annotated target: 19th day after eclosion.
database_cross_reference: FBC:DOS

day 20 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 19 of adulthood
definition: 20th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007095
comment: Temporal ordering number - 1000.

Axiom
annotated source: day 20 of adulthood
annotated property: definition
annotated target: 20th day after eclosion.
database_cross_reference: FBC:DOS

day 21 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 20 of adulthood
definition: 21st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007096
comment: Temporal ordering number - 1010.

Axiom
annotated source: day 21 of adulthood
annotated property: definition
annotated target: 21st day after eclosion.
database_cross_reference: FBC:DOS

day 22 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 21 of adulthood
definition: 22nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007097
comment: Temporal ordering number - 1020.

Axiom
annotated source: day 22 of adulthood
annotated property: definition
annotated target: 22nd day after eclosion.
database_cross_reference: FBC:DOS

day 23 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 22 of adulthood
definition: 23rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007098
comment: Temporal ordering number - 1030.

Axiom
annotated source: day 23 of adulthood
annotated property: definition
annotated target: 23rd day after eclosion.
database_cross_reference: FBC:DOS

day 24 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 23 of adulthood
definition: 24th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007099
comment: Temporal ordering number - 1040.

Axiom
annotated source: day 24 of adulthood
annotated property: definition
annotated target: 24th day after eclosion.
database_cross_reference: FBC:DOS

day 25 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 24 of adulthood
definition: 25th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007100
comment: Temporal ordering number - 1050.

Axiom
annotated source: day 25 of adulthood
annotated property: definition
annotated target: 25th day after eclosion.
database_cross_reference: FBC:DOS

day 26 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 25 of adulthood
definition: 26th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007101
comment: Temporal ordering number - 1060.

Axiom
annotated source: day 26 of adulthood
annotated property: definition
annotated target: 26th day after eclosion.
database_cross_reference: FBC:DOS

day 27 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 26 of adulthood
definition: 27th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007102
comment: Temporal ordering number - 1070.

Axiom
annotated source: day 27 of adulthood
annotated property: definition
annotated target: 27th day after eclosion.
database_cross_reference: FBC:DOS

day 28 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 27 of adulthood
definition: 28th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007103
comment: Temporal ordering number - 1080.

Axiom
annotated source: day 28 of adulthood
annotated property: definition
annotated target: 28th day after eclosion.
database_cross_reference: FBC:DOS

day 29 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 28 of adulthood
definition: 29th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007104
comment: Temporal ordering number - 1090.

Axiom
annotated source: day 29 of adulthood
annotated property: definition
annotated target: 29th day after eclosion.
database_cross_reference: FBC:DOS

day 30 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 29 of adulthood
definition: 30th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007105
comment: Temporal ordering number - 1100.

Axiom
annotated source: day 30 of adulthood
annotated property: definition
annotated target: 30th day after eclosion.
database_cross_reference: FBC:DOS

day 31 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 30 of adulthood
definition: 31st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007106
comment: Temporal ordering number - 1110.

Axiom
annotated source: day 31 of adulthood
annotated property: definition
annotated target: 31st day after eclosion.
database_cross_reference: FBC:DOS

day 32 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 31 of adulthood
definition: 32nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007107
comment: Temporal ordering number - 1120.

Axiom
annotated source: day 32 of adulthood
annotated property: definition
annotated target: 32nd day after eclosion.
database_cross_reference: FBC:DOS

day 33 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 32 of adulthood
definition: 33rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007108
comment: Temporal ordering number - 1130.

Axiom
annotated source: day 33 of adulthood
annotated property: definition
annotated target: 33rd day after eclosion.
database_cross_reference: FBC:DOS

day 34 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 33 of adulthood
definition: 34th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007109
comment: Temporal ordering number - 1140.

Axiom
annotated source: day 34 of adulthood
annotated property: definition
annotated target: 34th day after eclosion.
database_cross_reference: FBC:DOS

day 35 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 34 of adulthood
definition: 35th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007110
comment: Temporal ordering number - 1150.

Axiom
annotated source: day 35 of adulthood
annotated property: definition
annotated target: 35th day after eclosion.
database_cross_reference: FBC:DOS

day 36 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 35 of adulthood
definition: 36th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007111
comment: Temporal ordering number - 1160.

Axiom
annotated source: day 36 of adulthood
annotated property: definition
annotated target: 36th day after eclosion.
database_cross_reference: FBC:DOS

day 37 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 36 of adulthood
definition: 37th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007112
comment: Temporal ordering number - 1170.

Axiom
annotated source: day 37 of adulthood
annotated property: definition
annotated target: 37th day after eclosion.
database_cross_reference: FBC:DOS

day 38 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 37 of adulthood
definition: 38th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007113
comment: Temporal ordering number - 1180.

Axiom
annotated source: day 38 of adulthood
annotated property: definition
annotated target: 38th day after eclosion.
database_cross_reference: FBC:DOS

day 39 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 38 of adulthood
definition: 39th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007114
comment: Temporal ordering number - 1190.

Axiom
annotated source: day 39 of adulthood
annotated property: definition
annotated target: 39th day after eclosion.
database_cross_reference: FBC:DOS

day 40 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 39 of adulthood
definition: 40th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007115
comment: Temporal ordering number - 1200.

Axiom
annotated source: day 40 of adulthood
annotated property: definition
annotated target: 40th day after eclosion.
database_cross_reference: FBC:DOS

day 41 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 40 of adulthood
definition: 41st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007116
comment: Temporal ordering number - 1210.

Axiom
annotated source: day 41 of adulthood
annotated property: definition
annotated target: 41st day after eclosion.
database_cross_reference: FBC:DOS

day 42 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 41 of adulthood
definition: 42nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007117
comment: Temporal ordering number - 1220.

Axiom
annotated source: day 42 of adulthood
annotated property: definition
annotated target: 42nd day after eclosion.
database_cross_reference: FBC:DOS

day 43 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 42 of adulthood
definition: 43rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007118
comment: Temporal ordering number - 1230.

Axiom
annotated source: day 43 of adulthood
annotated property: definition
annotated target: 43rd day after eclosion.
database_cross_reference: FBC:DOS

day 44 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 43 of adulthood
definition: 44th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007119
comment: Temporal ordering number - 1240.

Axiom
annotated source: day 44 of adulthood
annotated property: definition
annotated target: 44th day after eclosion.
database_cross_reference: FBC:DOS

day 45 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 44 of adulthood
definition: 45th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007120
comment: Temporal ordering number - 1250.

Axiom
annotated source: day 45 of adulthood
annotated property: definition
annotated target: 45th day after eclosion.
database_cross_reference: FBC:DOS

day 46 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 45 of adulthood
definition: 46th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007121
comment: Temporal ordering number - 1260.

Axiom
annotated source: day 46 of adulthood
annotated property: definition
annotated target: 46th day after eclosion.
database_cross_reference: FBC:DOS

day 47 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 46 of adulthood
definition: 47th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007122
comment: Temporal ordering number - 1270.

Axiom
annotated source: day 47 of adulthood
annotated property: definition
annotated target: 47th day after eclosion.
database_cross_reference: FBC:DOS

day 48 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 47 of adulthood
definition: 48th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007123
comment: Temporal ordering number - 1280.

Axiom
annotated source: day 48 of adulthood
annotated property: definition
annotated target: 48th day after eclosion.
database_cross_reference: FBC:DOS

day 49 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 48 of adulthood
definition: 49th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007124
comment: Temporal ordering number - 1290.

Axiom
annotated source: day 49 of adulthood
annotated property: definition
annotated target: 49th day after eclosion.
database_cross_reference: FBC:DOS

day 50 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 49 of adulthood
definition: 50th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007125
comment: Temporal ordering number - 1300.

Axiom
annotated source: day 50 of adulthood
annotated property: definition
annotated target: 50th day after eclosion.
database_cross_reference: FBC:DOS

day 51 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 50 of adulthood
definition: 51st day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007126
comment: Temporal ordering number - 1310.

Axiom
annotated source: day 51 of adulthood
annotated property: definition
annotated target: 51st day after eclosion.
database_cross_reference: FBC:DOS

day 52 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 51 of adulthood
definition: 52nd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007127
comment: Temporal ordering number - 1320.

Axiom
annotated source: day 52 of adulthood
annotated property: definition
annotated target: 52nd day after eclosion.
database_cross_reference: FBC:DOS

day 53 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 52 of adulthood
definition: 53rd day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007128
comment: Temporal ordering number - 1330.

Axiom
annotated source: day 53 of adulthood
annotated property: definition
annotated target: 53rd day after eclosion.
database_cross_reference: FBC:DOS

day 54 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 53 of adulthood
definition: 54th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007129
comment: Temporal ordering number - 1340.

Axiom
annotated source: day 54 of adulthood
annotated property: definition
annotated target: 54th day after eclosion.
database_cross_reference: FBC:DOS

day 55 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 54 of adulthood
definition: 55th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007130
comment: Temporal ordering number - 1350.

Axiom
annotated source: day 55 of adulthood
annotated property: definition
annotated target: 55th day after eclosion.
database_cross_reference: FBC:DOS

day 56 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 55 of adulthood
definition: 56th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007131
comment: Temporal ordering number - 1360.

Axiom
annotated source: day 56 of adulthood
annotated property: definition
annotated target: 56th day after eclosion.
database_cross_reference: FBC:DOS

day 57 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 56 of adulthood
definition: 57th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007132
comment: Temporal ordering number - 1370.

Axiom
annotated source: day 57 of adulthood
annotated property: definition
annotated target: 57th day after eclosion.
database_cross_reference: FBC:DOS

day 58 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 57 of adulthood
definition: 58th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007133
comment: Temporal ordering number - 1380.

Axiom
annotated source: day 58 of adulthood
annotated property: definition
annotated target: 58th day after eclosion.
database_cross_reference: FBC:DOS

day 59 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 58 of adulthood
definition: 59th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007134
comment: Temporal ordering number - 1390.

Axiom
annotated source: day 59 of adulthood
annotated property: definition
annotated target: 59th day after eclosion.
database_cross_reference: FBC:DOS

day 60 of adulthood
type: Class
subclass of: adult age in days
subclass of: Restriction
  on property: substage_of
  some values from: adult stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: day 59 of adulthood
definition: 60th day after eclosion.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00007135
comment: Temporal ordering number - 1400.

Axiom
annotated source: day 60 of adulthood
annotated property: definition
annotated target: 60th day after eclosion.
database_cross_reference: FBC:DOS

early extended germ band stage
type: Class
subclass of: developmental stage
subclass of: Restriction
  on property: substage_of
  some values from: extended germ band stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: gastrula stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: embryonic stage 8
definition: A collective term for stages 9 and 10.
has_obo_namespace: FlyBase_development_CV
id: FBdv:00014201
comment: Temporal ordering number - 270.

Axiom
annotated source: early extended germ band stage
annotated property: definition
annotated target: A collective term for stages 9 and 10.
database_cross_reference: FBC:DOS

FBdv root 00000000
type: Class
IAO_0000231: IAO_0000227
term replaced by: Drosophila life
deprecated: true

mitotic M phase
type: Class
equivalent class: Class
  intersection of: M phase
  intersection of: Restriction
    on property: happens during
    some values from: mitotic cell cycle
subclass of: M phase
subclass of: mitotic cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
has_exact_synonym: M phase of mitotic cell cycle
has_exact_synonym: M-phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000087
in subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: cell cycle
  intersection of: Restriction
    on property: has part
    some values from: mitotic nuclear division
subclass of: cell cycle
subclass of: Restriction
  on property: has part
  some values from: mitotic nuclear division
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has_alternative_id: GO:0007067
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
has_related_synonym: mitosis
id: GO:0000278
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim yeast
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.

Axiom
annotated source: mitotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
database_cross_reference: Reactome:69278

M phase
type: Class
subclass of: cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: Wikipedia:M_phase
has_exact_synonym: M-phase
has_obo_namespace: biological_process
id: GO:0000279
in subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: GOC:mtg_cell_cycle

nuclear division
type: Class
subclass of: organelle fission
definition: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
has_obo_namespace: biological_process
has_related_synonym: karyokinesis
id: GO:0000280
in subset: goslim pir

Axiom
annotated source: nuclear division
annotated property: definition
annotated target: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
database_cross_reference: GOC:mah

molecular_function
type: Class
subclass of: process
IAO_0000589: molecular process

catalytic activity
type: Class
subclass of: molecular_function

organelle organization
type: Class
subclass of: cellular component organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
created by: jl
creation date: 2013-12-19T15:25:51Z
has_alternative_id: GO:1902589
has_exact_synonym: organelle organisation
has_exact_synonym: single organism organelle organization
has_obo_namespace: biological_process
has_related_synonym: organelle organization and biogenesis
has_related_synonym: single-organism organelle organization
id: GO:0006996
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim pir

Axiom
annotated source: organelle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:mah

Axiom
annotated source: organelle organization
annotated property: has_exact_synonym
annotated target: single organism organelle organization
database_cross_reference: GOC:TermGenie

Axiom
annotated source: organelle organization
annotated property: has_related_synonym
annotated target: organelle organization and biogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

cell cycle
type: Class
subclass of: cellular process
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: Wikipedia:Cell_cycle
has_exact_synonym: cell-division cycle
has_obo_namespace: biological_process
id: GO:0007049
in subset: gocheck do not manually annotate
in subset: goslim agr
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim flybase ribbon
in subset: goslim generic
in subset: goslim pir
in subset: goslim plant

Axiom
annotated source: cell cycle
annotated property: definition
annotated target: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_cell_cycle

multicellular organism development
type: Class
subclass of: multicellular organismal process
subclass of: anatomical structure development
definition: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
IAO_0000233: https://github.com/geneontology/go-ontology/issues/21234
has_obo_namespace: biological_process
id: GO:0007275
in subset: gocheck do not annotate
in subset: goslim chembl
in subset: goslim plant
comment: Note that this term was 'developmental process'.

Axiom
annotated source: multicellular organism development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

biological_process
type: Class
subclass of: process
definition: A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
created by: jl
creation date: 2012-09-19T15:05:24Z
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
has_alternative_id: GO:0044699
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_exact_synonym: physiological process
has_obo_namespace: biological_process
has_related_synonym: single organism process
has_related_synonym: single-organism process
id: GO:0008150
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
in subset: goslim pombe
in subset: goslim yeast
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.

Axiom
annotated source: biological_process
annotated property: definition
annotated target: A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
database_cross_reference: GOC:pdt

embryo development
type: Class
subclass of: multicellular organism development
definition: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
has_alternative_id: GO:0009795
has_broad_synonym: embryogenesis and morphogenesis
database_cross_reference: Wikipedia:Embryogenesis
has_exact_synonym: embryogenesis
has_exact_synonym: embryonal development
has_obo_namespace: biological_process
id: GO:0009790
in subset: gocheck do not manually annotate
in subset: goslim chembl
in subset: goslim generic
in subset: goslim plant

Axiom
annotated source: embryo development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_sensu

cellular process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
created by: jl
creation date: 2012-12-11T16:56:55Z
has_alternative_id: GO:0008151
has_alternative_id: GO:0044763
has_alternative_id: GO:0050875
has_exact_synonym: cell physiology
has_exact_synonym: cellular physiological process
has_narrow_synonym: cell growth and/or maintenance
has_obo_namespace: biological_process
has_related_synonym: single-organism cellular process
id: GO:0009987
in subset: goslim plant

Axiom
annotated source: cellular process
annotated property: definition
annotated target: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete

cellular component organization
type: Class
subclass of: cellular component organization or biogenesis
definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
has_alternative_id: GO:0044235
has_alternative_id: GO:0071842
has_exact_synonym: cell organisation
has_exact_synonym: cellular component organisation at cellular level
has_exact_synonym: cellular component organisation in other organism
has_exact_synonym: cellular component organization at cellular level
has_exact_synonym: cellular component organization in other organism
has_obo_namespace: biological_process
has_related_synonym: cell organization and biogenesis
id: GO:0016043
in subset: goslim agr
in subset: goslim mouse
in subset: goslim pir
in subset: goslim plant

Axiom
annotated source: cellular component organization
annotated property: definition
annotated target: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:ai
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation in other organism
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_related_synonym
annotated target: cell organization and biogenesis
database_cross_reference: GOC:mah

kinase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
subclass of: Restriction
  on property: is kinase activity
  has self: true

transferase activity
type: Class
subclass of: catalytic activity

transferase activity, transferring phosphorus-containing groups
type: Class
subclass of: transferase activity

cell cycle process
type: Class
equivalent class: Class
  intersection of: cellular process
  intersection of: Restriction
    on property: part of
    some values from: cell cycle
subclass of: cellular process
subclass of: Restriction
  on property: part of
  some values from: cell cycle
definition: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
has_obo_namespace: biological_process
id: GO:0022402
in subset: gocheck do not annotate

Axiom
annotated source: cell cycle process
annotated property: definition
annotated target: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_cell_cycle

cell cycle phase
type: Class
subclass of: biological phase
definition: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
id: GO:0022403
in subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: cell cycle phase
annotated property: definition
annotated target: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
database_cross_reference: GOC:mtg_cell_cycle

multicellular organismal process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
RO_0002161: NCBITaxon 4896
RO_0002161: NCBITaxon 4932
created by: jl
creation date: 2012-09-19T16:07:47Z
has_alternative_id: GO:0044707
has_alternative_id: GO:0050874
has_exact_synonym: organismal physiological process
has_obo_namespace: biological_process
has_related_synonym: single-multicellular organism process
id: GO:0032501
in subset: gocheck do not annotate
in subset: goslim pir

Axiom
annotated source: multicellular organismal process
annotated property: definition
annotated target: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
database_cross_reference: GOC:curators
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

developmental process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
created by: jl
creation date: 2012-12-19T12:21:31Z
has_alternative_id: GO:0044767
has_narrow_synonym: development
has_obo_namespace: biological_process
has_related_synonym: single-organism developmental process
id: GO:0032502
in subset: goslim agr
in subset: goslim aspergillus
in subset: goslim flybase ribbon
in subset: goslim pir

Axiom
annotated source: developmental process
annotated property: definition
annotated target: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
database_cross_reference: GOC:isa_complete

biological phase
type: Class
subclass of: biological_process
disjoint with: cellular component organization or biogenesis
definition: A distinct period or stage in a biological process or cycle.
created by: jl
creation date: 2014-07-16T13:12:40Z
has_obo_namespace: biological_process
id: GO:0044848
in subset: gocheck do not manually annotate
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.

Axiom
annotated source: biological phase
annotated property: definition
annotated target: A distinct period or stage in a biological process or cycle.
database_cross_reference: GOC:jl

mitotic cell cycle, embryonic
type: Class
subclass of: mitotic cell cycle
subclass of: Restriction
  on property: part of
  some values from: embryo development
definition: The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo.
has_obo_namespace: biological_process
id: GO:0045448

Axiom
annotated source: mitotic cell cycle, embryonic
annotated property: definition
annotated target: The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo.
database_cross_reference: GOC:go_curators

organelle fission
type: Class
subclass of: organelle organization
definition: The creation of two or more organelles by division of one organelle.
has_obo_namespace: biological_process
id: GO:0048285
in subset: goslim pir
in subset: goslim yeast

Axiom
annotated source: organelle fission
annotated property: definition
annotated target: The creation of two or more organelles by division of one organelle.
database_cross_reference: GOC:jid

anatomical structure development
type: Class
subclass of: developmental process
definition: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
has_exact_synonym: development of an anatomical structure
has_obo_namespace: biological_process
id: GO:0048856
in subset: goslim chembl
in subset: goslim generic
in subset: goslim plant

Axiom
annotated source: anatomical structure development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
database_cross_reference: GO_REF:0000021

interphase
type: Class
subclass of: cell cycle phase
definition: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
has_broad_synonym: resting phase
database_cross_reference: Wikipedia:Interphase
has_exact_synonym: karyostasis
has_obo_namespace: biological_process
id: GO:0051325
in subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: interphase
annotated property: definition
annotated target: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
database_cross_reference: GOC:mtg_cell_cycle

mitotic interphase
type: Class
equivalent class: Class
  intersection of: interphase
  intersection of: Restriction
    on property: happens during
    some values from: mitotic cell cycle
subclass of: interphase
subclass of: mitotic cell cycle phase
definition: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
has_exact_synonym: interphase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0051329
in subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic interphase
annotated property: definition
annotated target: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
database_cross_reference: GOC:mtg_cell_cycle

cellular component organization or biogenesis
type: Class
subclass of: cellular process
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
created by: mah
creation date: 2010-09-10T01:39:16Z
has_alternative_id: GO:0071841
has_exact_synonym: cellular component organisation or biogenesis
has_exact_synonym: cellular component organisation or biogenesis at cellular level
has_exact_synonym: cellular component organization or biogenesis at cellular level
has_obo_namespace: biological_process
id: GO:0071840
in subset: goslim flybase ribbon
in subset: goslim metagenomics

Axiom
annotated source: cellular component organization or biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular component organisation or biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular component organisation or biogenesis at cellular level
database_cross_reference: GOC:mah

mitotic cell cycle phase
type: Class
equivalent class: Class
  intersection of: cell cycle phase
  intersection of: Restriction
    on property: happens during
    some values from: mitotic cell cycle
subclass of: cell cycle phase
subclass of: Restriction
  on property: happens during
  some values from: mitotic cell cycle
definition: One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
id: GO:0098763
in subset: gocheck do not annotate
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic cell cycle phase
annotated property: definition
annotated target: One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
database_cross_reference: GOC:dos

mitotic nuclear division
type: Class
equivalent class: Class
  intersection of: nuclear division
  intersection of: Restriction
    on property: part of
    some values from: mitotic cell cycle
subclass of: nuclear division
subclass of: mitotic cell cycle process
definition: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/19910
created by: pg
creation date: 2017-03-23T14:44:23Z
has_exact_synonym: mitosis
has_obo_namespace: biological_process
id: GO:0140014
in subset: goslim chembl
in subset: goslim generic

Axiom
annotated source: mitotic nuclear division
annotated property: definition
annotated target: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
database_cross_reference: ISBN:0198547684

mitotic cell cycle process
type: Class
equivalent class: Class
  intersection of: cellular process
  intersection of: Restriction
    on property: part of
    some values from: mitotic cell cycle
subclass of: cell cycle process
subclass of: Restriction
  on property: part of
  some values from: mitotic cell cycle
definition: A process that is part of the mitotic cell cycle.
created by: jl
creation date: 2014-05-22T14:22:34Z
has_obo_namespace: biological_process
id: GO:1903047
in subset: gocheck do not annotate

Axiom
annotated source: mitotic cell cycle process
annotated property: definition
annotated target: A process that is part of the mitotic cell cycle.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GO_REF:0000060

infer input from direct reg
is rule enabled: true
comment: MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z
type: Imp
body: IndividualPropertyAtom
  property predicate: enables
  argument1: http://purl.obolibrary.org/obo/ro.owl#z
  argument2: http://purl.obolibrary.org/obo/ro.owl#y
body: IndividualPropertyAtom
  property predicate: directly regulates
  argument1: http://purl.obolibrary.org/obo/ro.owl#x
  argument2: http://purl.obolibrary.org/obo/ro.owl#y
body: ClassAtom
  class predicate: molecular_function
  argument1: http://purl.obolibrary.org/obo/ro.owl#x
body: ClassAtom
  class predicate: molecular_function
  argument1: http://purl.obolibrary.org/obo/ro.owl#y
head: IndividualPropertyAtom
  property predicate: has input
  argument1: http://purl.obolibrary.org/obo/ro.owl#x
  argument2: http://purl.obolibrary.org/obo/ro.owl#z

enabling an MF enables its parts
comment: GP(X)-enables->MF(Y)-has_part->MF(Z) => GP(X) enables MF(Z), e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase coupled transporter activity' has_part 'ATPase activity' then GP(X) enables 'ATPase activity'
type: Imp
body: ClassAtom
  class predicate: molecular_function
  argument1: y
body: IndividualPropertyAtom
  property predicate: enables
  argument1: x
  argument2: y
body: IndividualPropertyAtom
  property predicate: has part
  argument1: y
  argument2: z
head: IndividualPropertyAtom
  property predicate: enables
  argument1: x
  argument2: z

involved in BP
is rule enabled: true
comment: GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction'
type: Imp
body: ClassAtom
  class predicate: biological_process
  argument1: z
body: IndividualPropertyAtom
  property predicate: part of
  argument1: y
  argument2: z
body: IndividualPropertyAtom
  property predicate: enables
  argument1: x
  argument2: y
head: IndividualPropertyAtom
  property predicate: involved in
  argument1: x
  argument2: z

inferring direct reg edge from input to regulatory subfunction
comment: If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X. Note: this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this.
type: Imp
body: IndividualPropertyAtom
  property predicate: input of
  argument1: B
  argument2: C
body: IndividualPropertyAtom
  property predicate: enabled by
  argument1: A
  argument2: B
body: IndividualPropertyAtom
  property predicate: has regulatory component activity
  argument1: D
  argument2: C
head: IndividualPropertyAtom
  property predicate: directly regulates
  argument1: A
  argument2: D

inferring direct neg reg edge from input to regulatory subfunction
type: Imp
body: IndividualPropertyAtom
  property predicate: input of
  argument1: B
  argument2: C
body: IndividualPropertyAtom
  property predicate: enabled by
  argument1: A
  argument2: B
body: IndividualPropertyAtom
  property predicate: has negative regulatory component activity
  argument1: D
  argument2: C
head: IndividualPropertyAtom
  property predicate: directly negatively regulates
  argument1: A
  argument2: D

inferring direct positive reg edge from input to regulatory subfunction
type: Imp
body: IndividualPropertyAtom
  property predicate: input of
  argument1: B
  argument2: C
body: IndividualPropertyAtom
  property predicate: enabled by
  argument1: A
  argument2: B
body: IndividualPropertyAtom
  property predicate: has positive regulatory component activity
  argument1: D
  argument2: C
head: IndividualPropertyAtom
  property predicate: directly positively regulates
  argument1: A
  argument2: D

effector input is compound function input
type: Imp
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
body: IndividualPropertyAtom
  property predicate: has input
  argument1: eff
  argument2: in
head: IndividualPropertyAtom
  property predicate: has input
  argument1: mf
  argument2: in

Input of effector is input of its parent MF
type: Imp
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
body: IndividualPropertyAtom
  property predicate: has input
  argument1: mf
  argument2: in
head: IndividualPropertyAtom
  property predicate: has input
  argument1: eff
  argument2: in

Imp
comment: if effector directly regulates X, its parent MF directly regulates X
body: IndividualPropertyAtom
  property predicate: directly regulates
  argument1: mf
  argument2: mf2
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
head: IndividualPropertyAtom
  property predicate: directly regulates
  argument1: eff
  argument2: mf2

Imp
comment: if effector directly positively regulates X, its parent MF directly positively regulates X
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
body: IndividualPropertyAtom
  property predicate: directly positively regulates
  argument1: mf
  argument2: mf2
head: IndividualPropertyAtom
  property predicate: directly positively regulates
  argument1: eff
  argument2: mf2

if effector directly negatively regulates X, its parent MF directly negatively regulates X
type: Imp
body: IndividualPropertyAtom
  property predicate: directly negatively regulates
  argument1: mf
  argument2: mf2
body: IndividualPropertyAtom
  property predicate: has effector activity
  argument1: mf
  argument2: eff
head: IndividualPropertyAtom
  property predicate: directly negatively regulates
  argument1: eff
  argument2: mf2

'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).
type: Imp
body: IndividualPropertyAtom
  property predicate: overlaps
  argument1: x
  argument2: y
body: IndividualPropertyAtom
  property predicate: causally downstream of
  argument1: x
  argument2: y
head: ClassAtom
  class predicate: Nothing
  argument1: y
head: ClassAtom
  class predicate: Nothing
  argument1: x

'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).
type: Imp
body: IndividualPropertyAtom
  property predicate: overlaps
  argument1: x
  argument2: y
body: IndividualPropertyAtom
  property predicate: causally upstream of
  argument1: x
  argument2: y
head: ClassAtom
  class predicate: Nothing
  argument1: y
head: ClassAtom
  class predicate: Nothing
  argument1: x