OBO-Edit 1.002
03:03:2011 12:59
event
1.0
sakainoriko2
version: 1.72
definition
has_alternative_id
database_cross_reference
has_exact_synonym
has_narrow_synonym
has_obo_format_version
has_obo_namespace
event
negatively_regulates
negatively_regulates
event
part_of
part of
event
positively_regulates
positively_regulates
event
regulates
regulates
event
IEV:0000000
Event
event
IEV:0000001
Pathway
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
GO:0030154
event
IEV:0000002
Cell differentiation
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
GO:0030154
event
IEV:0000003
Biological event
event
IEV:0000004
Binding
Reversible reaction that can affect D,C,H,S,T,Y,R residues.
EC:2.7.-.-
GO:0016310
MI:0217
event
IEV:0000005
Phosphorylation
Reversible reaction that can affect D,C,H,S,T,Y,R residues.
MI:0217
event
IEV:0000006
Dissociation
event
IEV:0000007
Inactivation
event
IEV:0000008
Activation
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
GO:0006810
transport
event
IEV:0000009
Translocation
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
GO:0006810
Cleavage of peptide bonds with very broad specificity.
EC:3.4.25.1
event
IEV:0000010
Proteasome degradation
Cleavage of peptide bonds with very broad specificity.
EC:3.4.25.1
Phosphoresidues are cleaved and return D,C,H,S,T,Y or R residues.
MI:0203
event
IEV:0000011
Dephosphorylation
Phosphoresidues are cleaved and return D,C,H,S,T,Y or R residues.
MI:0203
Reversible reaction that create a covalent bond between a C-terminus G of ubiquitin and a K residue of the target.
EC:6.3.2.19
MI:0220
event
IEV:0000012
Ubiquitination
Reversible reaction that create a covalent bond between a C-terminus G of ubiquitin and a K residue of the target.
MI:0220
event
IEV:0000013
Binding in cytosol
event
IEV:0000014
Binding in plasma membrane
event
IEV:0000015
Binding in nucleus
event
IEV:0000016
Binding in extracellular
event
IEV:0000017
Binding in nuclear membrane
The directed movement of substances into the nucleus.
GO:0051170
import into nucleus
nucleus import
substance nuclear import
event
IEV:0000018
Nuclear import
The directed movement of substances into the nucleus.
GO:0051170
The directed movement of substances out of the nucleus.
GO:0051168
export from nucleus
nucleus export
substance nuclear export
event
IEV:0000019
Nuclear export
The directed movement of substances out of the nucleus.
GO:0051168
event
IEV:0000020
Activation in cytosol
event
IEV:0000021
Proteasome degradation in cytosol
event
IEV:0000022
Dephosphorylation in cytosol
event
IEV:0000023
Dissociation in cytosol
event
IEV:0000024
Inactivation in cytosol
event
IEV:0000025
Phosphorylation in cytosol
event
IEV:0000026
Ubiquitination in cytosol
The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell.
GO:0016055
KEGG:hsa04310
PubMed:15473860
Wnt receptor signaling pathway
Wnt signaling pathway (C. elegans)
Wnt signaling pathway (Drosophila)
Wnt signaling pathway (Mammalia)
Wnt signaling pathway (Xenopus)
event
IEV:0000027
Wnt signaling pathway
The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell.
GO:0016055
Wnt receptor signaling pathway
GO:0016055
event
IEV:0000028
Chemical treatment
IMR:0000055
IMR:0100755
PubMed:14636582
PubMed:15473860
event
IEV:0000029
Binding of Frizzled and DSH in cytosol
IMR:0100755
IMR:0100809
PubMed:10517632
PubMed:10656974
event
IEV:0000030
Phosphorylation of DSH by CK1 in cytosol
IMR:0100737
IMR:0100755
event
IEV:0000031
Inactivation of GSK3beta by DSH_p in cytosol
IMR:0000177
IMR:0000205
IMR:0000432
IMR:0100737
IMR:0100810
PubMed:15549094
event
IEV:0000032
Complex formation of Axin, APC, GSK3beta, CK1alpha and beta catenin in cytosol
event
IEV:0000033
Binding in mitochondria membrane
IMR:0000177
PubMed:15473860
PubMed:15549094
event
IEV:0000034
Nuclear import of beta catenin
IMR:0000177
IMR:0000418
PubMed:12210516
PubMed:15473860
event
IEV:0000035
Binding of beta-catenin and TCF in inner space of nucleus
IGS:0000028
IMR:0000418
PubMed:14755243
PubMed:15292219
PubMed:15473860
PubMed:15549094
event
IEV:0000036
Binding of TCF/LEF and responsive element in inner space of nucleus
true
event
IEV:0000038
Activation in unidentified cellular location
event
IEV:0000039
Proteasome degradation in unidentified cellular location
event
IEV:0000040
Dephosphorylation in unidentified cellular location
IMR:0000177
IMR:0000205
IMR:0000432
IMR:0100737
IMR:0100810
PubMed:15473860
PubMed:15549094
event
IEV:0000041
Dissociation of Axin, APC, GSK3beta, CK1alpha and beta-catenin in cytosol
IMR:0000003
IMR:0000055
PubMed:15473860
PubMed:15549094
PubMed:9288750
event
IEV:0000042
Binding of Wnt and Frizzled in extracellular
event
IEV:0000043
Inorganic chemical treatment
The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
IEV:0000137
GO:0007259
KEGG:hsa04630
event
IEV:0000044
JAK STAT pathway
The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
GO:0007259
IMR:0000006
IMR:0000095
PubMed:9974393
event
IEV:0000045
Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
IMR:0000095
IMR:0000374
PubMed:15541651
event
IEV:0000046
Binding of cytokine receptor and STAT in cytosol
The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
GO:0007261
IMR:0000374
PubMed:12039028
JAK-induced STAT protein dimerization
STAT dimerization
event
IEV:0000047
Dimerization of STAT in cytosol
The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
GO:0007261
The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
GO:0007262
IMR:0000374
PubMed:12039028
STAT protein nuclear translocation
event
IEV:0000048
Nuclear import of STAT dimer
The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
GO:0007262
IGS:0000028
IMR:0000374
PubMed:12039028
event
IEV:0000049
Binding of STAT dimer and responsive element in inner space of nucleus
IMR:0000374
PubMed:12039028
PubMed:14607831
event
IEV:0000050
Transcription by STAT dimer in nucleus
IMR:0000095
IMR:0000213
PubMed:12039028
event
IEV:0000051
Binding of cytokine receptor and JAK in cytosol
The process of introducing a phosphoric group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
GO:0042976
IMR:0000213
PubMed:9974393
activation of JAK protein
positive regulation of JAK protein activity by tyrosine phosphorylation
event
IEV:0000052
Autophosphorylation of Jak in cytosol
The process of introducing a phosphoric group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
GO:0042976
IMR:0000095
IMR:0000213
PubMed:15541651
event
IEV:0000053
Phosphorylation of cytokine receptor by Jak in cytosol
Bad inactivation signaling
Bad phosphorylation signaling
event
IEV:0000054
Bad inactivation signaling
event
IEV:0000055
PKA-Bad signaling
event
IEV:0000056
RSK-Bad signaling
true
event
IEV:0000059
TGF beta super family signaling pathway (through p38 cascade)
event
IEV:0000060
Grb2-Sos-Ras-PI3K signaling
IMR:0000898
IMR:0002721
IMR:0002730
IMR:0002736
Phosphorylation of 4EBP by TOR of TOR:LST8:Raptor in cytosol
Phosphorylation of 4EBP by mTOR in cytosol
event
IEV:0000061
Phosphorylation of 4EBP by TOR of TORC1 in cytosol
PubMed:16870827
JAK STAT signaling pathway (Angiotensin induced)
event
IEV:0000062
JAK STAT signaling (Angiotensin induced)
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
event
IEV:0000063
IL1 signaling (through IKK-NF-kappaB cascade)
event
IEV:0000064
Organic chemical treatment
event
IEV:0000065
PLC beta signaling
CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
IEV:0000066
CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
IMR:0002721
IMR:0002730
IMR:0002736
IMR:0002798
Activation of p70S6K by mTOR
Phosphorylation of S6K1 by TOR of TOR:LST8:Raptor in cytosol
event
IEV:0000067
Phosphorylation of S6K1 by TOR of TORC1 in cytosol
IMR:0100712
PubMed:14985712
event
IEV:0000068
Translocation of Notch (NIC) from plasma membrane to cytosol
event
IEV:0000069
Cellular event
A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine.
GO:0006915
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
apoptotic cell death
apoptotic programmed cell death
programmed cell death by apoptosis
event
IEV:0000070
Apoptosis (Inhibition of cell survival)
A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine.
GO:0006915
event
IEV:0000071
Molecular event
The process by which a dormant state is induced, maintained and broken. Dormancy is characterized by a suspension of physiological activity.
GO:0022611
event
IEV:0000072
Dormancy
The process by which a dormant state is induced, maintained and broken. Dormancy is characterized by a suspension of physiological activity.
GO:0022611
event
IEV:0000073
Bud dormancy
The process by which a dormant state is induced and maintained in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated once dormancy is broken.
GO:0010162
event
IEV:0000074
Seed dormancy
The process by which a dormant state is induced and maintained in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated once dormancy is broken.
GO:0010162
event
IEV:0000075
Disease
The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population.
GO:0008283
event
IEV:0000076
Cell proliferation
The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population.
GO:0008283
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
GO:0007049
MeSH:D002453
event
IEV:0000077
Cell cycle
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
GO:0007049
The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M).
GO:0007050
arrest of cell cycle progression
cessation of cell cycle
termination of cell cycle
event
IEV:0000078
Cell cycle arrest
The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M).
GO:0007050
A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components.
GO:0000910
event
IEV:0000079
Cytokinesis
A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components.
GO:0000910
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
GO:0060290
event
IEV:0000080
Transdifferentiation
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
GO:0060290
event
IEV:0000081
Epithelial to mesenchymal transdifferentiation
event
IEV:0000082
Organism event
GO:0032502
event
IEV:0000083
Development
The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
GO:0045444
adipocyte cell differentiation
adipose cell differentiation
fat cell differentiation
event
IEV:0000084
Adipocyte differentiation
The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
GO:0045444
adipocyte cell differentiation
GO:0045444
adipose cell differentiation
GO:0045444
fat cell differentiation
GO:0045444
The process whereby a relatively unspecialized cell acquires specialized features of a myoblast, a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
GO:0045445
event
IEV:0000085
Myoblast differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a myoblast, a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
GO:0045445
Differentiation of the osteoblast; which is the mesodermal cell that gives rise to bone.
GO:0001649
event
IEV:0000086
Osteoblast differentiation
Differentiation of the osteoblast; which is the mesodermal cell that gives rise to bone.
GO:0001649
Any process that stops, prevents or reduces the rate, frequency or extent of adipocyte differentiation.
GO:0045599
negative regulation of fat cell differentiation
event
IEV:0000087
Inhibition of Adipocyte differentiation
Any process that stops, prevents or reduces the rate, frequency or extent of adipocyte differentiation.
GO:0045599
negative regulation of fat cell differentiation
GO:0045599
Any process that stops, prevents or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
GO:0045662
event
IEV:0000088
Negative regulation of myoblast differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
GO:0045662
Any process that stops, prevents or reduces the rate, frequency or extent of osteoblast differentiation.
GO:0045668
event
IEV:0000089
Negative regulation of osteoblast differentiation
Any process that stops, prevents or reduces the rate, frequency or extent of osteoblast differentiation.
GO:0045668
event
IEV:0000090
TGF beta super family signaling pathway
The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
GO:0016049
cellular growth
growth of cell
event
IEV:0000091
Cell growth
The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
GO:0016049
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
GO:0007010
cytoskeleton organisation
event
IEV:0000092
Cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
GO:0007010
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
GO:0030032
event
IEV:0000093
Lamellipodium biogenesis
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
GO:0030032
event
IEV:0000094
Membrane ruffling
Assembly of a stress fiber, the bundle of microfilaments and other proteins found in fibroblasts.
GO:0043149
event
IEV:0000095
Stress fiber formation
Assembly of a stress fiber, the bundle of microfilaments and other proteins found in fibroblasts.
GO:0043149
event
IEV:0000096
Ecodormancy
The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
GO:0008219
event
IEV:0000097
Cell death
The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
GO:0008219
Any process involved in the immunological reaction of an organism to an immunogenic stimulus.
GO:0006955
event
IEV:0000098
Immune response
Any process involved in the immunological reaction of an organism to an immunogenic stimulus.
GO:0006955
oncogenesis
event
IEV:0000099
Tumorigenesis
true
Cell death resulting from activation of endogenous cellular processes.
GO:0012501
event
IEV:0000101
Programmed cell death
Cell death resulting from activation of endogenous cellular processes.
GO:0012501
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.
GO:0000279
event
IEV:0000102
M phase
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.
GO:0000279
Any process involved in the controlled movement of a cell.
GO:0006928
cell movement
event
IEV:0000103
Cell motion
Any process involved in the controlled movement of a cell.
GO:0006928
The orderly movement of cells from one site to another, often during the development of a multicellular organism.
GO:0016477
event
IEV:0000104
Cell migration
The orderly movement of cells from one site to another, often during the development of a multicellular organism.
GO:0016477
The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules.
GO:0007155
KEGG:hsa04510
event
IEV:0000105
Cell adhesion
The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules.
GO:0007155
The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
GO:0007610
event
IEV:0000106
Behavior
The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
GO:0007610
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050853
KEGG:hsa04662
PubMed:14632637
B lymphocyte receptor signaling pathway
B-cell receptor signaling pathway
B-lymphocyte receptor signaling pathway
event
IEV:0000107
B cell receptor signaling pathway
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050853
B lymphocyte receptor signaling pathway
GO:0050853
B-cell receptor signaling pathway
GO:0050853
B-lymphocyte receptor signaling pathway
GO:0050853
event
IEV:0000108
Toll-like receptor signaling pathway (p38 cascade)
Negative regulation of BAD phosphorylation signaling
event
IEV:0000109
Negative regulation of BAD inactivation signaling
true
REACT:22272.1
event
IEV:0000110
IL1 signaling pathway
event
IEV:0000111
Skeletal muscle hypertrophy
KEGG:hsa04150
AKT(PKB)-mTOR signaling
mTOR signaling
event
IEV:0000112
AKT(PKB)-TOR signaling
IEV:0000119
TNFR2 Signaling Pathway
event
IEV:0000113
TNFR1 signaling pathway (through NF-kappaB cascade)
GO:0008624
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
REACT:1432.1
TNF signaling
event
IEV:0000114
TNFR1 signaling pathway (through caspase cascade)
A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases.
Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
PubMed:14734786
ERK1 and ERK2 cascade
ERK1/2 cascade
event
IEV:0000115
ERK cascade
A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases.
Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
GO:0070371
OBSOLETE: remap to 'Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty' IEV:0003547.
event
IEV:0000116
Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty (Drosophila)
true
OBSOLETE: remap to 'Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty' IEV:0003547.
XX:<new dbxref>
OBSOLETE: remap to 'Negative feedback regulation of Ras-Raf-MAPK signaling by spred' IEV:0003546.
event
IEV:0000117
Negative feedback regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
true
OBSOLETE: remap to 'Negative feedback regulation of Ras-Raf-MAPK signaling by spred' IEV:0003546.
XX:<new dbxref>
Reversible reaction that create a covalent bond between a C-terminus G of an ubiquitine like sumo protein and a K residue of the target.
MI:0566
event
IEV:0000118
SUMOylation
Reversible reaction that create a covalent bond between a C-terminus G of an ubiquitine like sumo protein and a K residue of the target.
MI:0566
true
event
IEV:0000120
TPO signaling pathway
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon.
GO:0016056
event
IEV:0000121
Rhodopsin mediated signaling pathway
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon.
GO:0016056
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
GO:0043161
proteasomal pathway
proteasomal ubiquitin-dependent protein breakdown
proteasomal ubiquitin-dependent protein catabolic process
proteasomal ubiquitin-dependent protein catabolism
proteasomal ubiquitin-dependent protein degradation
event
IEV:0000122
Proteasome mediated protein degradation signaling
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
GO:0043161
event
IEV:0000123
PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
GO:0007229
KEGG:hsa04510
event
IEV:0000124
Integrin signaling pathway
Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
GO:0007229
The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.
GO:0007215
glutamate signaling pathway
event
IEV:0000125
Glutamate receptor signaling pathway
The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.
GO:0007215
Insulin receptor signaling pathway (through ERK cascade)
event
IEV:0000126
Insulin receptor signaling pathway (through Shc mediated signaling)
KEGG:hsa04510
event
IEV:0000127
Integrin signaling pathway (through ERK cascade)
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
event
IEV:0000128
Caspase Cascade
IMR:0000453
REACT:341.2
Oligomerization of BAX at the mitochondrial membrane
event
IEV:0000129
Oligomerization of Bax in cytosol
GO:0008054
event
IEV:0000130
Cyclin E degradation signaling
IMR:0000248
IMR:0100288
event
IEV:0000131
Phosphorylation of Bad by RSK in cytosol
IMR:0000213
IMR:0000460
event
IEV:0000132
Binding of SOCS and JAK in cytosol
event
IEV:0000133
Growth hormone signaling pathway (JAK2, STAT5)
event
IEV:0000134
IL4 signaling pathway (JAK1, JAK3, STAT6)
event
IEV:0000135
IL3 signaling pathway (JAK1, JAK2, STAT5)
PubMed:8700888
IL2 signaling pathway (JAK1, JAK3, STAT5)
event
IEV:0000136
IL2 signaling (JAK1, JAK3, STAT5)
true
PubMed:10415122
event
IEV:0000138
IL12 signaling pathway (JAK2, TYK2, STAT4)
PubMed:10433356
IL10 signaling pathway (JAK1, TYK2, STAT3)
event
IEV:0000139
IL10 signaling (JAK1, TYK2, STAT3)
IL7 signaling pathway (JAK1, JAK3, STAT5)
event
IEV:0000140
IL7 signaling (JAK1, JAK3, STAT5)
The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
GO:0009908
Flowering
event
IEV:0000141
Flower development
The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
GO:0009908
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO:0040007
event
IEV:0000142
Growth
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO:0040007
IMR:0000213
IMR:0000460
event
IEV:0000143
Negative feedback regulation of JAK STAT pathway by (binding of SOCS and JAK)
true
event
IEV:0000145
Regulation pathway
IMR:0000213
IMR:0000273
event
IEV:0000146
Dephosphorylation of Jak by PTP in cytosol
IMR:0000095
IMR:0000273
event
IEV:0000147
Dephosphorylation of cytokine receptor by PTP in cytosol
IMR:0002914
PubMed:15021887
event
IEV:0000148
Negative regulation of transcription by PIAS
IMR:0000273
IMR:0000374
event
IEV:0000149
Dephosphorylation of STAT dimer by PTP in cytosol
Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.
GO:0046426
event
IEV:0000150
Negative regulation of JAK STAT pathway
Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.
GO:0046426
IMR:0000095
IMR:0000460
event
IEV:0000151
Negative feedback regulation of JAK STAT pathway by (binding of SOCS and cytokine receptor)
IMR:0000095
IMR:0000460
event
IEV:0000152
Binding of SOCS and Cytokine receptor in cytosol
event
IEV:0000153
Cell survival (Inhibition of apoptosis)
IMR:0000036
IMR:0000092
event
IEV:0000154
Binding of TGF beta superfamily and TGF beta superfamily receptor I/II in extracellular
IMR:0000371
IMR:0100315
event
IEV:0000155
Transcription by R-Smad:Smad4 in nucleus
IGS:0000028
IMR:0000371
IMR:0000424
IMR:0100315
event
IEV:0000156
Binding of R-Smad:Smad4 complex, Coactivator and responsive element in inner space of nucleus
GO:0007182
IMR:0000371
IMR:0000710
event
IEV:0000157
Phosphorylation of R-Smad by TGF beta receptor I in cytosol
GO:0007184
IMR:0000371
IMR:0100315
event
IEV:0000158
Nuclear import of R-Smad:Smad4
GO:0007183
IMR:0000371
IMR:0100315
event
IEV:0000159
Complex formation of R-Smad and Smad4 in cytosol
IMR:0000710
IMR:0000712
event
IEV:0000160
Phosphorylation of TGF-b receptor I by TGF beta receptor II in cytosol
GO:0008624
REACT:900.1
FasL/ CD95L signaling
event
IEV:0000161
Fas signaling pathway (through caspase cascade)
Any series of molecular signals generated as a consequence of an estrogen binding to its receptor.
GO:0030520
event
IEV:0000162
Estrogen receptor signaling pathway
Any series of molecular signals generated as a consequence of an estrogen binding to its receptor.
GO:0030520
event
IEV:0000163
fMLP signaling pathway
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
GO:0007219
KEGG:hsa04330
PubMed:14985712
N signaling pathway
event
IEV:0000164
Notch signaling pathway
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
GO:0007219
N signaling pathway
GO:0007219
event
IEV:0000165
p53 signaling pathway (through p21)
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
PI3K-AKT(PKB)-Bad signaling
event
IEV:0000166
AKT(PKB)-Bad signaling
GO:0008633
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
REACT:584.3
Activation, translocation and oligomerization of BAX
Bax dimerization signaling
event
IEV:0000167
Bax activation signaling
event
IEV:0000168
Endodormancy
event
IEV:0000169
Oxidation in unidentified cellular location
IMR:0100261
IMR:0100288
IMR:0100293
REACT:1062.2
BAD displaces tBID from BCL-2 sequestration
event
IEV:0000170
Binding of Bad and Bcl-2/Bcl-xL in mitochondria membrane
event
IEV:0000171
Oxidation in cytosol
event
IEV:0000172
Paradormancy
event
IEV:0000173
Negative regulation of Fas signaling pathway
event
IEV:0000174
Binding outside the mitochondria membrane
event
IEV:0000175
Translocation from mitochondria membrane to cytosol
IMR:0001206
REACT:535.3
Release of Cytochrome c from mitochondria
event
IEV:0000176
Permeabilization of mitochondria and Translocation of Cyt c from mitochondria to cytosol
event
IEV:0000177
Negative regulation of Caspase cascade (through mitochondria)
IMR:0001204
IMR:0001206
REACT:1640.2
Cytochrome C Binds to Apaf-1
event
IEV:0000178
Binding of Cyt c and Apaf1 in cytosol
IMR:0100261
IMR:0100293
event
IEV:0000179
Binding of Cyt c and Bcl-2/Bcl-xL
IMR:0100261
event
IEV:0000180
Phosphorylation of Bcl-2 in cytosol
IMR:0000092
event
IEV:0000181
Internalization of TGF beta receptor
The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010467
event
IEV:0000182
Gene expression
The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010467
The synthesis of either RNA on a template of DNA or DNA on a template of RNA.
GO:0006350
event
IEV:0000183
Transcription
The synthesis of either RNA on a template of DNA or DNA on a template of RNA.
GO:0006350
EC:3 catalyzed process
EC:3.-.-.-
GO:0016787
lyase activity
event
IEV:0000184
Hydrolysis
EC:3 catalyzed process
EC:3.-.-.-
event
IEV:0000185
Environmental event
event
IEV:0000186
Binding in unidentified cellular location
event
IEV:0000187
Phosphorylation in unidentified cellular location
event
IEV:0000188
Negative regulation of NF-kappaB signaling (cytoplasmic sequestering)
IMR:0000382
event
IEV:0000189
Binding of NF-kappaB and specific modules in cytosol
event
IEV:0000190
Induction of (Para) dormancy
GO:0004908
IMR:0000011
IMR:0000120
event
IEV:0000191
Binding of IL1 and IL1R complex in extracellular
IMR:0000890
IMR:0100465
event
IEV:0000192
Binding of MyD88 and IRAK1 in cytosol
IMR:0000120
IMR:0000894
event
IEV:0000193
Binding of IL-1R complex and Tollip in cytosol
IMR:0000892
IMR:0100465
event
IEV:0000194
Binding of MyD88 and IRAK4 in cytosol
IMR:0000120
IMR:0100465
event
IEV:0000195
Binding of IL1-R complex and MyD88 in cytosol
IMR:0000890
IMR:0000894
event
IEV:0000196
Binding of Tollip and IRAK1 in cytosol
IMR:0000890
IMR:0000892
event
IEV:0000197
Phosphorylation of IRAK1 by IRAK4 in cytosol
event
IEV:0000198
Phosphorylation in plasma membrane
event
IEV:0000199
GDP-GTP exchange in plasma membrane
IMR:0000890
IMR:0100427
event
IEV:0000200
Binding of IRAK1_p and TRAF6 in cytosol
IMR:0000232
IMR:0000441
IMR:0000890
IMR:0000893
IMR:0100427
event
IEV:0000201
Binding of IRAK1:TRAF6 and TAK1:TAB1:TAB2 in cytosol
IMR:0100427
event
IEV:0000202
Ubiquitination of TRAF6 in cytosol
event
IEV:0000203
Lyase process in cytosol
event
IEV:0000204
Ubiquitination in unidentified cellular location
IMR:0000890
event
IEV:0000205
Ubiquitination of IRAK1_p in cytosol
event
IEV:0000206
Proteasome degradation in plasma membrane
IMR:0000890
event
IEV:0000207
Proteasome degradation of IRAK1_p in cytosol
A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
GO:0007249
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
PubMed:15134788
I-kappaB kinase/NF-kappaB cascade
NIK-I-kappaB/NF-kappaB cascade
event
IEV:0000208
IKK-NF-kappaB cascade
A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
GO:0007249
I-kappaB kinase/NF-kappaB cascade
GO:0007249
NIK-I-kappaB/NF-kappaB cascade
GO:0007249
IMR:0000232
IMR:0000242
event
IEV:0000209
Phosphorylation of NIK by TAK1 in cytosol
IEV:0001265
IMR:0000464
PubMed:15134788
Proteasome degradation of I-kappaB by 26S proteasome in cytosol
event
IEV:0000210
Proteasome degradation of I-kappaB in cytosol
event
IEV:0000211
Release of (eco) dormancy
IEV:0001266
IMR:0000464
PubMed:15134788
Ubiquitination of I-kappaB in cytosol
event
IEV:0000212
Ubiquitination of I-kappaB_p in cytosol
GO:0007252
IMR:0000243
IMR:0000464
PubMed:15134788
Phosphorylation of I-kappaB_p by IKK complex_p [mammals]
event
IEV:0000213
Phosphorylation of I-kappaB_p by IKK complex_p in cytosol
GO:0007253
IMR:0000382
IMR:0000464
PubMed:15134788
event
IEV:0000214
Binding of NF-kappaB and I-kappaB in cytosol
GO:0008588
IMR:0000382
IMR:0000464
PubMed:15134788
Dissociation of NF-kappaB and I-kappaB [mammals]
event
IEV:0000215
Dissociation of NF-kappaB and I-kappaB in cytosol
The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
GO:0042348
IMR:0000382
PubMed:15134788
NF-kappaB import into nucleus
NF-kappaB protein-nucleus import
NF-kappaB transport from cytoplasm to nucleus
NF-kappaB-nucleus import
event
IEV:0000216
Nuclear import of NF-kappaB
The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
GO:0042348
IGS:0000028
IMR:0000382
PubMed:11973130
event
IEV:0000217
Binding of NF-kappaB and responsive element in inner space of nucleus
IMR:0000006
IMR:0000382
event
IEV:0000218
Gene expression of cytokine by NF-kappaB
The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
GO:0006412
event
IEV:0000219
Translation
The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
GO:0006412
true
event
IEV:0000221
Metabolic reaction
Reaction that can affect K or G residues.
MI:0214
event
IEV:0000222
Myristoylation
Reaction that can affect K or G residues.
MI:0214
GDP+ phosphate = GTP + H2O
event
IEV:0000223
GDP-GTP exchange
GDP+ phosphate = GTP + H2O
XX:<new dbxref>
IL1 signaling pathway (through JNK cascade)
event
IEV:0000224
IL-1 signaling (through JNK cascade)
IMR:0000006
IMR:0000414
event
IEV:0000225
Gene expression of cytokine by AP-1
A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
GO:0007254
event
IEV:0000226
JNK cascade
A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
GO:0007254
The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress.
GO:0007256
IMR:0000229
IMR:0000262
activation of JNKK activity
event
IEV:0000227
Phosphorylation of MKK4/7 by MAPKKK in cytosol
The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress.
GO:0007256
activation of JNKK activity
GO:0007256
GO:0007257
IMR:0000225
IMR:0000262
event
IEV:0000228
Phosphorylation of JNK by MKK4/7_p in cytosol
IMR:0000225
event
IEV:0000229
Nuclear import of JNK_p
The process of introducing a phosphoric group into a JUN protein.
GO:0007258
IMR:0000225
IMR:0000817
event
IEV:0000230
Phosphorylation of c-Jun by JNK_p in inner space of nucleus
The process of introducing a phosphoric group into a JUN protein.
GO:0007258
event
IEV:0000231
Phosphorylation in nucleus
IL1 signaling pathway (through p38 cascade)
event
IEV:0000232
IL-1 signaling (through p38 cascade)
IMR:0000369
event
IEV:0000233
Gene expression by transcriptional regulator
event
IEV:0000234
p38 cascade
IMR:0000226
IMR:0000263
event
IEV:0000235
Phosphorylation of p38 by MKK3/6_p in cytosol
IMR:0000229
IMR:0000263
IMR:0100454
event
IEV:0000236
Phosphorylation of MKK3/4/6 by MAPKKK in cytosol
IMR:0000226
event
IEV:0000237
Nuclear import of p38_p
IMR:0000226
IMR:0000369
event
IEV:0000238
Phosphorylation of transcriptional regulator by p38_p in inner space of nucleus
event
IEV:0000239
Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
IMR:0001438
IMR:0001439
IMR:0001440
IMR:0001655
event
IEV:0000240
Binding of LPS and TLR4:MD-2:CD14 in extracellular
IMR:0001438
IMR:0001439
IMR:0001440
IMR:0100465
event
IEV:0000241
Binding of TLR4:MD-2:CD14 and MyD88 in cytosol
IMR:0100465
IMR:0100488
event
IEV:0000242
Binding of MyD88 and IRAK in cytosol
IMR:0100488
event
IEV:0000243
Activation of IRAK in cytosol
event
IEV:0000244
Activation in plasma membrane
event
IEV:0000245
Inactivation in extracellular
event
IEV:0000246
Inactivation in unidentified cellular location
IMR:0100427
IMR:0100488
event
IEV:0000247
Binding of activated IRAK and TRAF6 in cytosol
IMR:0000232
IMR:0000441
IMR:0000893
IMR:0100427
event
IEV:0000248
Binding of TRAF6 and TAB1:TAB2:TAK1 in cytosol
event
IEV:0000249
Reduction in cytosol
GO:0007250
IMR:0000229
IMR:0000243
event
IEV:0000250
Phosphorylation of IKK complex by MAPKKK in cytosol
IMR:0000025
IMR:0000060
REACT:2096.2
TNF Binds TNF-R1
event
IEV:0000251
Binding of TNF alpha homotrimer and TNFR1 in extracellular
IMR:0000060
TNFR1 trimerization
event
IEV:0000253
Trimerization of TNFR1 in plasma membrane
IMR:0000060
IMR:0100464
event
IEV:0000254
Binding of TNFR1 trimer and TRADD in cytosol
IMR:0100423
IMR:0100464
event
IEV:0000255
Binding of TRADD and TRAF2 in cytosol
IMR:0000269
IMR:0100423
event
IEV:0000256
Activation of RIP by TRAF2 in cytosol
IMR:0000269
IMR:0100451
event
IEV:0000257
Activation of MEKK3 by RIP in cytosol
IMR:0002372
PubMed:15343367
TCR-CD3 complex formation
event
IEV:0000258
Complex formation of TCR-CD3 in plasma membrane
IMR:0000465
IMR:0002372
IMR:0100294
PubMed:15343367
event
IEV:0000259
Binding of antigen, TCR-CD3 complex and CD4 in extracellular
IMR:0002372
IMR:0100353
event
IEV:0000260
Binding of TCR-CD3 complex and Lck in cytosol
true
IMR:0002372
IMR:0100352
event
IEV:0000262
Binding of TCR-CD3 complex and Fyn in cytosol
IMR:0000221
IMR:0000348
PubMed:15343367
event
IEV:0000263
Phosphorylation of LAT by ZAP-70_p in cytosol
IMR:0000434
IMR:0000682
event
IEV:0000264
Phosphorylation of Vav by non-receptor tyrosine kinase in cytosol
IMR:0000265
IMR:0000434
event
IEV:0000265
Phosphorylation of Vav by PI3K in cytosol
IMR:0000221
IMR:0100353
PubMed:12040176
Phosphorylation of ZAP-70 by autophosphorylated Lck in cytosol
event
IEV:0000266
Phosphorylation of ZAP-70 by Lck_p in cytosol
IMR:0000285
IMR:0000348
event
IEV:0000267
Binding of LAT_p and PLC gamma in cytosol
IMR:0000285
IMR:0001350
IMR:0100027
IMR:0100028
event
IEV:0000268
Hydrolysis of PIP2 by PLC gamma to generate DAG and IP3 in cytosol
event
IEV:0000269
Hydrolysis in plasma membrane
IMR:0000245
IMR:0100027
PubMed:7499357
event
IEV:0000270
Binding of DAG and PKC and active conformational change of PKC in cytosol
true
IMR:0000084
IMR:0100028
event
IEV:0000272
Binding of IP3 and IP3R and IP3R opening
event
IEV:0000273
Binding in ER membrane
IMR:0000499
IMR:0100031
event
IEV:0000274
Calcium ion transport from ER to cytosol through calcium ion channel
true
event
IEV:0000276
Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
IMR:0002655
IMR:0002658
IMR:0002662
PubMed:11973130
event
IEV:0000277
Trimerization of MALT1:CARMA1:BCL10 in cytosol
IMR:0000473
IMR:0002950
ISBN:081533642X
PubMed:15343367
event
IEV:0000278
Binding of CD28 and CD80/CD86 in extracellular
event
IEV:0000279
Reduction in unidentified cellular location
CD4 T cell receptor signaling pathway (through Ras and ERK cascade)
event
IEV:0000280
CD4 T cell receptor signaling (through Ras and ERK cascade)
CD4 T cell receptor signaling pathway (through Vav, Rac and JNK cascade)
event
IEV:0000281
CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
IMR:0000232
event
IEV:0000282
Activation of TAK1 in cytosol
IMR:0000063
IMR:0000285
event
IEV:0000283
Binding of RTK and PLC gamma in cytosol
IMR:0000284
IMR:0001352
event
IEV:0000284
Binding of PLC and PIP3 in cytosol
true
IEV:0000285
IMR:0000285
IMR:0000682
PubMed:14993283
Phosphorylation of PLC gamma by syk
event
IEV:0000286
Phosphorylation of PLC gamma by non-receptor tyrosine kinase in cytosol
event
IEV:0000287
Negative regulation of PLC gamma signaling (through LAT)
IMR:0000265
IMR:0001350
event
IEV:0000288
Phosphorylation of PIP2 by PI3K in plasma membrane
IMR:0000348
IMR:0000741
PubMed:15343367
event
IEV:0000289
Binding of LAT_p and Gads in cytosol
true
The Physical Association of Protein Kinase Ctheta with a Lipid Raft-Associated Inhibitor of kB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-kB Cascade by TCR and CD28.
IMR:0000243
IMR:0100484
PubMed:11120819
PubMed:11973130
Activation of NF-kappaB by PKC
NF-kappaB activation
event
IEV:0000291
Activation of IKK complex by PKC theta in cytosol
The Physical Association of Protein Kinase Ctheta with a Lipid Raft-Associated Inhibitor of kB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-kB Cascade by TCR and CD28.
PubMed:11120819
NF-kappaB activation
PubMed:14632637
event
IEV:0000292
Medication
event
IEV:0000293
Medium condition
event
IEV:0000294
Plant hormone medication
event
IEV:0000295
KBM (medium)
event
IEV:0000296
KBM-2 (medium)
event
IEV:0000297
MEGM (medium)
event
IEV:0000298
MEBM (medium)
event
IEV:0000299
BEBM (medium)
event
IEV:0000300
SABM (medium)
event
IEV:0000301
PrEGM (medium)
event
IEV:0000302
PrEBM (medium)
event
IEV:0000304
DMEM (medium)
event
IEV:0000305
199 medium
event
IEV:0000306
Animal cell medium
event
IEV:0000307
KGM-2 (medium)
event
IEV:0000308
Rat cell medium
event
IEV:0000309
Mouse cell medium
event
IEV:0000310
Neuronal cell medium
event
IEV:0000311
ES cell medium
event
IEV:0000312
HeLa medium
event
IEV:0000313
BME medium
event
IEV:0000314
Mouse L-cell medium
event
IEV:0000315
Hepatocyte medium
event
IEV:0000316
Epidermal keratinocyto medium
event
IEV:0000317
Macrophage medium
event
IEV:0000318
Amniocyte medium
event
IEV:0000319
Peripheral blood medium
event
IEV:0000320
Bone marrow medium
event
IEV:0000321
Human hematopoietic cell medium
event
IEV:0000322
Lymphocyte medium
event
IEV:0000323
CHO medium
event
IEV:0000324
DG44 medium
event
IEV:0000325
293 medium
event
IEV:0000326
COS-7 medium
event
IEV:0000327
MDCK medium
event
IEV:0000328
VERO medium
event
IEV:0000329
BHK-21 medium
event
IEV:0000330
PK-15 medium
event
IEV:0000331
CV-1 medium
event
IEV:0000332
WI-38 medium
event
IEV:0000333
Hybridoma cell medium
event
IEV:0000334
HEp2 medium
event
IEV:0000335
A549 medium
event
IEV:0000336
BSC-1 medium
event
IEV:0000337
Ham's F-10 medium
event
IEV:0000338
Myeloma medium
event
IEV:0000339
Ham's F-12 medium
event
IEV:0000340
IMDM (medium)
event
IEV:0000341
Chicken aortic smooth muscle cell medium
event
IEV:0000342
Fibroblast medium
event
IEV:0000343
All-purpose medium
event
IEV:0000344
MEM (medium)
event
IEV:0000346
Alpha MEM (medium)
event
IEV:0000348
Jurkat cell medium
event
IEV:0000349
HL60 medium
event
IEV:0000350
Waymouth's medium
event
IEV:0000351
Mesenchymal cell medium
event
IEV:0000352
Human bronchial epithelial cell medium
event
IEV:0000353
Mammary epithelial cell medium
event
IEV:0000354
Human prostate epithelial cell medium
event
IEV:0000355
SAGM (medium)
event
IEV:0000356
BEGM (medium)
event
IEV:0000357
KGM (medium)
event
IEV:0000362
Human vascular smooth muscle medium
event
IEV:0000363
Human vascular endothelial cell medium
event
IEV:0000365
Cambium dormancy
A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0022402
KEGG:hsa04110
event
IEV:0000366
Cell cycle process
A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0022402
true
Progression from G2 phase to M phase of the mitotic cell cycle.
GO:0000086
KEGG:hsa04110
event
IEV:0000368
G2-M-phase transition
Progression from G2 phase to M phase of the mitotic cell cycle.
GO:0000086
IMR:0100600
IMR:0100614
event
IEV:0000369
Binding of Cdk4 and cyclin D in cytosol
IMR:0100600
IMR:0100602
IMR:0100636
REACT:96.4
event
IEV:0000370
Phosphorylation of Cdk4/6 by CAK in cytosol
event
IEV:0000371
Temperature treatment
event
IEV:0000372
Radiation treatment
event
IEV:0000373
Wavelength of light treatment
event
IEV:0000374
Photoperiod treatment
event
IEV:0000375
Freeze treatment
event
IEV:0000376
Cold temperature treatment
event
IEV:0000377
High temperature treatment
event
IEV:0000378
Low temperature treatment
event
IEV:0000379
Heat treatment
event
IEV:0000380
Physical stimulus treatment
event
IEV:0000381
Gravity treatment
event
IEV:0000382
Oxidation
event
IEV:0000383
Contact pressure treatment
event
IEV:0000384
Magnetic force treatment
event
IEV:0000385
Electricity treatment
event
IEV:0000386
FK506 medication
event
IEV:0000387
Treatment
IMR:0100600
IMR:0100614
event
IEV:0000388
Nuclear import of Cdk4:cyclin D
IMR:0000461
IMR:0100600
event
IEV:0000389
Phosphorylation of RB by Cdk4_p in inner space of nucleus
IMR:0000461
IMR:0000848
REACT:1882.4
event
IEV:0000390
Dissociation of E2F and RB_p in inner space of nucleus
event
IEV:0000391
Negative regulation of G1-S-phase transition
IMR:0100614
REACT:715.2
event
IEV:0000392
Ubiquitination of Cyclin D in cytosol
The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.
GO:0006260
MeSH:D004261
REACT:383.2
event
IEV:0000393
DNA replication
The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.
GO:0006260
EC:6.2.1
event
IEV:0000394
CoA ligation
true
The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers.
GO:0009809
lignin anabolism
lignin biosynthetic process
lignin formation
lignin synthesis
event
IEV:0000396
Lignin biosynthesis
The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers.
GO:0009809
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
GO:0009790
embryogenesis
embryonal development
event
IEV:0000397
Embryonic development
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
GO:0009790
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
GO:0009791
event
IEV:0000398
Post embryonic development
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
GO:0009791
true
IEV:0000781
IMR:0100024
IMR:0100702
PubMed:15023366
Dissociation of PKA catalytic subunit and regulatory subunit
event
IEV:0000400
Binding of c-AMP and PKA regulatory subunits and active conformational change in cytosol
IMR:0000249
IMR:0100288
event
IEV:0000401
Phosphorylation of Bad by PKA in cytosol
IMR:0000250
IMR:0100299
event
IEV:0000402
Phosphorylation of caspase9 by AKT in cytosol
IMR:0000250
IMR:0100288
REACT:188.2
Akt1 phosphorylates BAD protein
event
IEV:0000403
Phosphorylation of Bad by AKT_p
IMR:0000456
IMR:0100288
REACT:1139.2
Sequesteration of BAD protein by 14-3-3
event
IEV:0000404
Binding of Bad_p and 14-3-3 in cytosol
IMR:0100288
event
IEV:0000405
Translocation of Bad_p from mitochondria membrane to cytosol
GO:0008633
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
REACT:549.2
Activation of BAD and translocation to mitochondria
Bad dephosphorylation signaling
event
IEV:0000406
Bad activation signaling
KEGG:C01494
event
IEV:0000407
Oxidation of ferulate in cytosol
IMR:0000250
IMR:0000255
event
IEV:0000408
Phosphorylation of AKT by PDK1
event
IEV:0000409
Removement of survival factor
true
GO:0001844
IMR:0100288
REACT:2046.3
Translocation of activated BAD protein to mitochondria
event
IEV:0000411
Translocation of Bad from the cytosol to the mitochondria membrane
event
IEV:0000412
Translocation from cytosol to mitochondria membrane
IMR:0000278
IMR:0100288
REACT:1663.2
Activation of BAD by calcineurin
event
IEV:0000413
Dephosphorylation of Bad_p by calcineurin in cytosol
event
IEV:0000414
Dephosphorylation in plasma membrane
KEGG:C00811
event
IEV:0000415
Oxidation of 4-coumarate in cytosol
KEGG:C02646
KEGG:C05615
event
IEV:0000416
Peroxidation of 4-Coumaryl alcohol to Lignin (grasses) in cytosol
KEGG:C00590
event
IEV:0000417
Translocation of Coniferyl alcohol to cell wall
KEGG:C02646
event
IEV:0000418
Translocation of 4-Coumaryl alcohol to cell wall
EC:2.1.1.104
KEGG:C00323
KEGG:R01942
event
IEV:0000419
O-methyltransferase of caffeoyl-CoA by CCR in cytosol
KEGG:C00423
event
IEV:0000420
Hydroxylation of trans-cinnamate by C4H in the cytosol
KEGG:C02325
KEGG:C05615
event
IEV:0000421
Peroxidation of sinapyl alcohol to Lignin (angiosperm and grasses) in cytosol
EC:6.2.1.12
IMR:0200354
KEGG:C00223
KEGG:C01197
KEGG:R01943
event
IEV:0000422
CoA ligation of caffeic acid by 4CL in cytosol
EC:6.2.1.12
IMR:0200354
KEGG:C00223
KEGG:C00811
KEGG:R01616
event
IEV:0000423
CoA ligation of 4-coumarate by 4CL in cytosol
EC:6.2.1.12
IMR:0200354
KEGG:C00223
KEGG:C01494
KEGG:R02194
event
IEV:0000424
CoA ligation of ferulate by 4CL in cytosol
EC:2.1.1.68
KEGG:C01197
KEGG:R03366
event
IEV:0000425
O-methyl-transfer of caffeic acid by OMT in cytosol
EC:6.2.1.12
IMR:0200354
KEGG:C00223
KEGG:C05619
KEGG:R06583
event
IEV:0000426
CoA ligation of 5-Hydroxyferulate by 4CL in cytosol
KEGG:C00590
KEGG:C05615
event
IEV:0000427
Peroxidation of coniferyl alcohol to Lignin (gymnosperm, angiosperm and grasses) in cytosol
KEGG:C02325
event
IEV:0000428
Translocation of sinapyl alcohol to cell wall
event
IEV:0000429
Translocation from cytosol to cell wall
event
IEV:0000430
CoA ligation in cytosol
event
IEV:0000431
CoA ligation inside of the plasma membrane
event
IEV:0000432
CoA ligation in unidentified cellular location
The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Irreversible reaction that can affect A,G,M,F,P,C,R,N,Q,E,H,or K residues.
EC:2.1.1.-
MI:0213
event
IEV:0000433
Transmethylation
The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Irreversible reaction that can affect A,G,M,F,P,C,R,N,Q,E,H,or K residues.
MI:0213
event
IEV:0000434
Transmethylation in unidentified cellular location
event
IEV:0000435
Transmethylation in cytosol
event
IEV:0000436
Isoprenylation in cytosol
Irreversible reaction that can affect K,P,Y or R residues.
MI:0210
event
IEV:0000437
Hydroxylation
Irreversible reaction that can affect K,P,Y or R residues.
MI:0210
event
IEV:0000438
Hydroxylation in the cytosol
event
IEV:0000439
Hydroxylation in the unidentified cellular location
event
IEV:0000440
Farnesylation in cytosol
event
IEV:0000441
Lignin biosynthesis (angiosperm)
event
IEV:0000442
Lignin biosynthesis (gymnosperm)
event
IEV:0000443
Lignin biosynthesis (grasses)
GO:0001844
IMR:0000453
REACT:1286.3
Translocation of activated BAX to the mitochondria
event
IEV:0000444
Translocation of Bax from the cytosol to the mitochondria membrane
Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
GO:0000165
KEGG:hsa04010
MAP kinase cascade
MAP kinase kinase kinase cascade
MAPK cascade
event
IEV:0000445
MAPKKK cascade
Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
GO:0000165
MAP kinase cascade
GO:0000165
MAP kinase kinase kinase cascade
GO:0000165
GO:0007260
IMR:0000213
IMR:0000374
PubMed:12039028
event
IEV:0000446
Phosphorylation of STAT by JAK_p in cytosol
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
GO:0009653
anatomical structure organization
morphogenesis
event
IEV:0000447
Anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
GO:0009653
anatomical structure organization
GO:0009653
morphogenesis
GO:0009653
The process of blood cell formation. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
GO:0030097
Haemopoiesis
Hemopoiesis
blood cell biosynthesis
blood cell formation
event
IEV:0000448
Hematopoiesis
The process of blood cell formation. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
GO:0030097
OBSOLETE: remap to 'Negative regulation of Ras-Raf-MAPK signaling by spred' IEV:0003544.
event
IEV:0000449
Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
true
OBSOLETE: remap to 'Negative regulation of Ras-Raf-MAPK signaling by spred' IEV:0003544.
XX:<new dbxref>
Insulin receptor signaling pathway (through AKT-Bad signaling)
event
IEV:0000452
Insulin receptor signaling pathway (through IRS mediated signaling)
IMR:0100659
UniProt:Q13315
event
IEV:0000453
Phosphorylation of p53 by ATM in inner space of nucleus
The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
GO:0048009
PubMed:15205477
IGF receptor signaling pathway
insulin-like growth factor receptor signaling pathway
event
IEV:0000454
IGF signaling pathway
The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
GO:0048009
IGF receptor signaling pathway
GO:0048009
insulin-like growth factor receptor signaling pathway
GO:0048009
event
IEV:0000455
TNFR1 signaling pathway (through JNK cascade)
IMR:0100218
IMR:0100423
event
IEV:0000456
Binding of TRAF2 and ASK1 in cytosol
IMR:0100463
IMR:0100464
REACT:1766.1
TRADD:TRAF2:RIP1 complex binds FADD
event
IEV:0000457
Binding of TRADD and FADD in cytosol
event
IEV:0000458
Protein activation/inactivation signaling
event
IEV:0000459
Autophosphorylation in unidentified cellular location
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050852
KEGG:hsa04660
T lymphocyte receptor signaling pathway
T-cell receptor signaling pathway
T-lymphocyte receptor signaling pathway
event
IEV:0000460
T cell receptor signaling pathway
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050852
T lymphocyte receptor signaling pathway
GO:0050852
T-cell receptor signaling pathway
GO:0050852
T-lymphocyte receptor signaling pathway
GO:0050852
event
IEV:0000461
Regulation of p53 signaling pathway
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
GO:0002224
KEGG:hsa04620
TLR signaling pathway
event
IEV:0000462
Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
Toll-like receptor signaling pathway
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
GO:0002224
TLR signaling pathway
GO:0002224
event
IEV:0000463
Negative regulation of p53 signaling pathway
event
IEV:0000464
Positive regulation of p53 signaling pathway
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
Death Receptor Signalling
Extrinsic Pathway for Apoptosis
induction of apoptosis by extracellular signals
event
IEV:0000465
TNFR signaling pathway
IMR:0000227
event
IEV:0000466
Nuclear import of ERK_p
IEV:0000058
IEV:0000271
IEV:0000468
PubMed:10579907
PLC gamma signaling (through BLNK)
PLC gamma signaling (through LAT)
PLC gamma signaling (through RTK)
event
IEV:0000467
T cell=PLC gamma1, B cell=gamma2, PDGFR=PLC gamma1
PLC gamma signaling
true
activation of PLC gamma, PLC gamma_SH2 or PH domain
IMR:0000285
IMR:0001352
event
IEV:0000469
Binding of PLC gamma and PIP3 in cytosol
activation of PLC gamma, PLC gamma_SH2 or PH domain
XX:<new dbxref>
IMR:0000286
IMR:0001352
event
IEV:0000470
Binding of PLC beta and PIP3 in cytosol
phospholipase C signaling
event
IEV:0000471
PLC signaling
IMR:0000284
IMR:0001350
IMR:0100027
IMR:0100028
event
IEV:0000472
Hydrolysis of PIP2 by PLC to generate DAG and IP3 in cytosol
IMR:0000286
IMR:0001350
IMR:0100027
IMR:0100028
event
IEV:0000473
Hydrolysis of PIP2 by PLC beta to generate DAG and IP3 in cytosol
The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK.
IEV:0002094
GO:0000186
IMR:0000229
IMR:0000259
Phosphorylation of MKK by MAPKKK
activation of MAPKK activity
event
IEV:0000474
Phosphorylation of MAPKK by MAPKKK in cytosol
The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK.
GO:0000186
activation of MAPKK activity
GO:0000186
IMR:0000229
IMR:0000261
event
IEV:0000475
Phosphorylation of MEK1/2(MKK1/2) by MAPKKK in cytosol
IMR:0000227
IMR:0000261
PubMed:14734786
event
IEV:0000476
Phosphorylation of ERK by MEK1/2(MKK1/2)_p in cytosol
IMR:0000227
IMR:0000369
event
IEV:0000477
Phosphorylation of transcriptional regulator by ERK_p in inner space of nucleus
The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK.
GO:0000187
IMR:0000224
IMR:0000259
activation of MAP kinase
activation of MAPK activity
event
IEV:0000478
Phosphorylation of MAPK by MAPKK in cytosol
The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK.
GO:0000187
Dually phosphorylated MAPK, or dpERK, phosphorylates protein targets in both the cytoplasm and nucleus.
IMR:0000224
IMR:0000369
event
IEV:0000479
Phosphorylation of transcriptional regulator by MAPK_p in inner space of nucleus
Dually phosphorylated MAPK, or dpERK, phosphorylates protein targets in both the cytoplasm and nucleus.
PubMed:16771628
The directed movement of a MAP kinase to the nucleus upon activation.
GO:0000189
IMR:0000224
nuclear translocation of MAPK
event
IEV:0000480
Nuclear import of MAPK (through MAPKKK cascade)
The directed movement of a MAP kinase to the nucleus upon activation.
GO:0000189
event
IEV:0000481
Autophosphorylation in cytosol
CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
event
IEV:0000482
CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
IMR:0000245
IMR:0100031
PubMed:7499357
event
IEV:0000483
Binding of calcium ion and PKC and active conformational change of PKC in cytosol
IMR:0000245
IMR:0100027
IMR:0100031
PubMed:7499357
event
IEV:0000484
Binding of DAG, calcium ion and PKC and active conformational change of PKC in cytosol
IMR:0000008
PubMed:11973130
event
IEV:0000485
Transcription of IL-2 in nucleus
event
IEV:0000486
Autophosphorylation in plasma membrane
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
GO:0008286
REACT:498.5
Insulin receptor mediated signalling
event
IEV:0000487
Insulin receptor signaling pathway
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
GO:0008286
IMR:0000052
IMR:0000078
REACT:1459.4
Insulin binding
event
IEV:0000488
Binding of insulin and insulin receptor in extracellular
IMR:0000078
REACT:2211.3
event
IEV:0000489
Autophosphorylation of insulin receptor in plasma membrane
GO:0046777
event
IEV:0000490
Autophosphorylation
IMR:0000078
IMR:0000347
REACT:106.2
Binding of SHC to insulin receptor
event
IEV:0000491
Binding of insulin receptor and Shc in cytosol
IMR:0000078
IMR:0000347
REACT:2015.2
Phosphorylation of SHC
event
IEV:0000492
Phosphorylation of Shc by insulin receptor in cytosol
IMR:0000078
IMR:0000347
REACT:596.2
Dissociation of SHC-P from insulin receptor
event
IEV:0000493
Dissociation of Shc and insulin receptor in cytosol
IMR:0000078
IMR:0000351
REACT:2120.3
Binding of IRS to insulin receptor
event
IEV:0000494
Binding of IRS and insulin receptor in cytosol
IMR:0000078
IMR:0000351
REACT:342.3
Phosphorylation of IRS
event
IEV:0000495
Phosphorylation of IRS by insulin receptor in cytosol
IMR:0000078
IMR:0000351
REACT:562.2
Dissociation of IRS-P from insulin receptor
event
IEV:0000496
Dissociation of IRS and insulin receptor in cytosol
IMR:0000078
REACT:599.2
event
IEV:0000497
Internalisation of the insulin receptor
REACT:1109.2
event
IEV:0000498
Insulin receptor recycling
IMR:0001051
IMR:0200030
REACT:2002.3
Endosome acidification
event
IEV:0000499
Influx of hydrogen ion into the lumen of the endosome by proton pump
IMR:0000052
IMR:0000078
REACT:134.2
Dissociation of insulin from insulin receptor
event
IEV:0000500
Dissociation of insulin and insulin receptor in extracellular
Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling.
GO:0046627
event
IEV:0000501
Negative regulation of insulin signaling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling.
GO:0046627
IMR:0000078
IMR:0000273
REACT:453.3
Insulin receptor de-phosphorylation
event
IEV:0000502
Dephosphorylation of Insulin receptor by PTP in cytosol
IMR:0000078
REACT:490.2
Re-integration of insulin receptor into plasma membrane
event
IEV:0000503
Translocation of insulin receptor from the endosome to plasma membrane
event
IEV:0000504
Translocation from cytosol into lumen of endosome
event
IEV:0000505
Translocation from endosome to plasma membrane
event
IEV:0000506
Dissociation in extracellular
event
IEV:0000507
Dissociation in unidentified cellular location
event
IEV:0000508
Translocation from plasma membrane to cytosol
IMR:0001045
IMR:0100353
PubMed:11781344
PubMed:12040176
Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by CD45 and active conformational change
event
IEV:0000509
Dephosphorylation of Lck_p by CD45 and active conformational change
IMR:0100353
PubMed:11781344
PubMed:15034556
event
IEV:0000510
Autophosphorylation of Lck and active conformational change in cytosol
IMR:0100294
IMR:0100353
PubMed:15343367
event
IEV:0000511
Binding of CD4 and Lck in extracellular
Negative regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
IEV:0000512
Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
IMR:0000273
PubMed:11781344
PubMed:12040176
PubMed:15034556
event
IEV:0000513
Lck inactivation signaling (through PTP)
IMR:0100346
IMR:0100352
PubMed:11781344
event
IEV:0000514
Phosphorylation of PAG/Cbp by Fyn in cytosol
IMR:0000212
IMR:0100346
PubMed:11781344
event
IEV:0000515
Binding of PAG/Cbp_p and Csk in cytosol
IMR:0000212
IMR:0100342
PubMed:11781344
event
IEV:0000516
Binding of Csk and PEP in cytosol
UniProt:Q14249
event
IEV:0000517
DNA fragmentation by EndoG in inner space of nucleus
IMR:0100342
IMR:0100353
PubMed:11781344
Dephosphorylation of Lck_p (autophosphorylated) by PEP in cytosol
event
IEV:0000518
Dephosphorylation of Lck_p by PEP in cytosol
IMR:0000273
PubMed:11781344
PubMed:12040176
PubMed:15034556
event
IEV:0000519
Lck activation signaling (through autophosphorylation and PTP)
event
IEV:0000520
Regulation of Src family activation signaling
IMR:0000144
IMR:0000465
PubMed:15343367
event
IEV:0000521
Binding of antigen and MHC II in extracellular
IMR:0100287
IMR:0100353
PubMed:12040176
Phosphorylation of CD3 zeta by Lck (autophosphorylated) in cytosol
event
IEV:0000522
Phosphorylation of CD3 zeta by Lck_p in cytosol
IMR:0100287
IMR:0100352
Phosphorylation of CD3 zeta by Fyn (autophosphorylated) in cytosol
event
IEV:0000523
Phosphorylation of CD3 zeta by Fyn_p in cytosol
IEV:0000261
IMR:0000221
IMR:0100287
PubMed:15343367
Binding of TCR-CD3 complex and Zap-70
event
IEV:0000524
Binding of CD3 zeta and ZAP-70 in cytosol
IMR:0000221
IMR:0100352
Phosphorylation of ZAP-70 by autophosphorylated Fyn in cytosol
event
IEV:0000525
Phosphorylation of ZAP-70 by Fyn_p in cytosol
IMR:0000221
IMR:0000271
event
IEV:0000526
Dephosphorylation of ZAP-70_p by SHIP-1 in cytosol
IEV:0000290
IMR:0000221
IMR:0000350
PubMed:15343367
Phosphorylation of SLP-76 by Zap-70
event
IEV:0000527
Phosphorylation of SLP-76 by ZAP-70_p in cytosol
IMR:0000350
IMR:0000741
PubMed:15343367
event
IEV:0000528
Binding of Gads and SLP-76 in cytosol
T-cell
IMR:0000732
IMR:0100354
PubMed:11752630
event
IEV:0000529
Phosphorylation of PLC gamma1 by Itk in cytosol
T-cell
XX:<new dbxref>
IMR:0000222
IMR:0000285
PubMed:14632637
event
IEV:0000530
Phosphorylation of PLC gamma by Syk in cytosol
IMR:0000350
IMR:0100354
PubMed:12040176
event
IEV:0000531
Binding of SLP-76 and Itk in cytosol
IMR:0001651
IMR:0100699
event
IEV:0000532
Phosphorylation of PI by PI4K in plasma membrane
IMR:0000268
IMR:0001348
event
IEV:0000533
Phosphorylation of PIP by PI5K in plasma membrane
IMR:0001350
event
IEV:0000534
Binding of PIP2 and actin-binding protein in cytosol
IMR:0000273
PubMed:15034556
event
IEV:0000535
Fyn activation signaling (through autophosphorylation and PTP)
IMR:0100352
PubMed:15034556
event
IEV:0000536
Autophosphorylation of Fyn and active conformational change in cytosol
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
event
IEV:0000537
Interaction in nucleus
true
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
XX:<new dbxref>
Regulation of BAD phosphorylation signaling
event
IEV:0000538
Regulation of BAD inactivation signaling
true
event
IEV:0000539
Regulation of Caspase cascade
Positive regulation of BAD phosphorylation signaling
event
IEV:0000540
Positive regulation of BAD inactivation signaling
true
event
IEV:0000541
Positive regulation of Caspase cascade (through mitochondria)
Regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
IEV:0000542
Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
Positive regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
IEV:0000543
Positive regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
event
IEV:0000544
Regulation of Fas signaling pathway
event
IEV:0000545
Positive regulation of Fas signaling pathway
event
IEV:0000546
Regulation of G1-S-phase transition
event
IEV:0000547
Positive regulation of G1-S-phase transition
Any process that modulates the frequency, rate or extent of insulin receptor signaling.
GO:0046626
event
IEV:0000548
Regulation of insulin receptor signaling pathway
Any process that modulates the frequency, rate or extent of insulin receptor signaling.
GO:0046626
Any process that increases the frequency, rate or extent of insulin receptor signaling.
GO:0046628
event
IEV:0000549
Positive regulation of insulin receptor signaling pathway
Any process that increases the frequency, rate or extent of insulin receptor signaling.
GO:0046628
Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.
GO:0046425
event
IEV:0000550
Regulation of JAK STAT pathway
Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.
GO:0046425
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
GO:0046427
event
IEV:0000551
Positive regulation of JAK STAT pathway
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
GO:0046427
event
IEV:0000552
Regulation of NF-kappaB signaling (cytoplasmic sequestering)
event
IEV:0000553
Positive regulation of NF-kappaB signaling (cytoplasmic sequestering)
event
IEV:0000554
Regulation of PLC gamma signaling
event
IEV:0000555
Positive regulation of PLC gamma signaling (through LAT)
OBSOLETE: remap to 'Regulation of Ras-Raf-MAPK signaling by spred' IEV:0003543.
event
IEV:0000556
Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
true
OBSOLETE: remap to 'Regulation of Ras-Raf-MAPK signaling by spred' IEV:0003543.
XX:<new dbxref>
OBSOLETE: remap to 'Positive regulation of Ras-Raf-MAPK signaling by spred' IEV:0003545.
event
IEV:0000557
Positive regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
true
OBSOLETE: remap to 'Positive regulation of Ras-Raf-MAPK signaling by spred' IEV:0003545.
XX:<new dbxref>
IMR:0000273
PubMed:11781344
PubMed:15034556
event
IEV:0000558
Fyn inactivation signaling (through PTP)
event
IEV:0000559
Negative regulation of Src family activation signaling
event
IEV:0000560
Positive regulation of Src family activation signaling
PubMed:11724969
event
IEV:0000561
ZAP-70 and CD3 degradation signaling
IMR:0000221
IMR:0100344
PubMed:11724969
event
IEV:0000562
Ubiquitination of ZAP-70 by c-Cbl in cytosol
IMR:0000147
IMR:0100344
PubMed:11724969
event
IEV:0000563
Ubiquitination of CD3_p by c-Cbl in cytosol
IMR:0000221
IMR:0000310
PubMed:11724969
event
IEV:0000564
Proteasome degradation of ZAP-70 by 26S proteasome in cytosol
IMR:0000147
IMR:0000310
PubMed:11724969
event
IEV:0000565
Proteasome degradation of CD3 by 26S proteasome in cytosol
PubMed:12024036
event
IEV:0000566
Syk degradation signaling
IMR:0000222
IMR:0100344
PubMed:12024036
event
IEV:0000567
Ubiquitination of Syk by c-Cbl in cytosol
IMR:0000222
IMR:0000310
PubMed:12024036
event
IEV:0000568
Proteasome degradation of Syk by 26S proteasome in cytosol
PubMed:11904433
event
IEV:0000569
Lck degradation signaling
IMR:0100344
IMR:0100353
PubMed:11904433
event
IEV:0000570
Ubiquitination of Lck by c-Cbl in cytosol
IMR:0000310
IMR:0100353
PubMed:11904433
event
IEV:0000571
Proteasome degradation of Lck by 26S proteasome in cytosol
REACT:18424.1
UniProt:P18509
UniProt:P41586
event
IEV:0000572
Binding of PACAP and PACAP receptor in cytosol
IMR:0000221
IMR:0000682
PubMed:12040176
PubMed:15343367
event
IEV:0000573
Phosphorylation of ZAP-70 by non-receptor tyrosine kinase in cytosol
The developmental processes by which defined structures within an embryo are generated.
GO:0048598
event
IEV:0000574
Embryonic morphogenesis
The developmental processes by which defined structures within an embryo are generated.
GO:0048598
The process, occurring after embryonic development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
GO:0009886
post-embryonic morphogenesis of an anatomical structure
event
IEV:0000575
Post-embryonic morphogenesis
The process, occurring after embryonic development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
GO:0009886
Morphogenesis of a tissue or tissues that function together to perform a specific function. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.
GO:0009887
histogenesis and organogenesis
event
IEV:0000576
Organ morphogenesis
Morphogenesis of a tissue or tissues that function together to perform a specific function. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.
GO:0009887
histogenesis and organogenesis
GO:0009887
The process by which the anatomical structures of the flower are generated and organized. Morphogenesis pertains to the creation of form.
GO:0048439
event
IEV:0000577
Flower morphogenesis
The process by which the anatomical structures of the flower are generated and organized. Morphogenesis pertains to the creation of form.
GO:0048439
The regrowth of lost or destroyed tissues.
IEV:0000100
GO:0042246
Tissue repair
event
IEV:0000578
Tissue regeneration
The regrowth of lost or destroyed tissues.
GO:0042246
IMR:0000172
event
IEV:0000579
Binding of extracellular matrix and Integrin complex in extracellular
IMR:0000172
IMR:0000540
event
IEV:0000580
Binding of extracellular matrix protein and integrin complex in extracellular
IMR:0000172
IMR:0000515
Integrin complex and caveolin complex formation
event
IEV:0000581
Complex formation of integrin complex and caveolin in plasma membrane
IMR:0000172
IMR:0001714
event
IEV:0000582
Binding of integrin complex and talin in cytosol
IMR:0000185
event
IEV:0000583
Complex formation of integrin-dependent membrane-skeletal protein in cytosol
IMR:0000172
IMR:0000218
event
IEV:0000584
Binding of integrin complex and FAK in cytosol
IMR:0000172
UniProt:Q9HBL0
event
IEV:0000585
Binding of Integrin complex and tensin in cytosol
IMR:0000187
IMR:0000218
event
IEV:0000586
Binding of FAK and paxillin in cytosol
IMR:0000218
IMR:0000355
event
IEV:0000587
Binding of FAK and p130Cas in cytosol
IMR:0000189
IMR:0000190
event
IEV:0000588
Binding of alpha-actinin and F actin in cytosol
IMR:0000190
UniProt:Q9HBL0
event
IEV:0000589
Binding of tensin and F actin in cytosol
IMR:0000190
IMR:0001711
PubMed:8632828
event
IEV:0000590
Binding of vinculin and F actin in cytosol
IMR:0000190
IMR:0001714
event
IEV:0000591
Binding of talin and F actin in cytosol
IMR:0000189
UniProt:Q15942
event
IEV:0000592
Binding of alpha-actinin and zyxin in cytosol
IMR:0000218
event
IEV:0000593
Autophosphorylation of FAK in cytosol
IMR:0000211
IMR:0000218
event
IEV:0000594
Phosphorylation of FAK by Src family in cytosol
IMR:0000211
IMR:0000355
event
IEV:0000595
Phosphorylation of p130Cas by Src family in cytosol
IMR:0000187
IMR:0000211
event
IEV:0000596
Phosphorylation of paxillin by Src family in cytosol
IMR:0000211
IMR:0000218
event
IEV:0000597
Binding of FAK and Src family in cytosol
IMR:0000335
IMR:0000355
event
IEV:0000598
Binding of p130Cas and Crk in cytosol
IMR:0000218
IMR:0000340
event
IEV:0000599
Binding of FAK and Grb2 in cytosol
IMR:0000347
IMR:0100352
event
IEV:0000600
Binding of Fyn and Shc in cytosol
IMR:0000347
IMR:0100352
event
IEV:0000601
Phosphorylation of Shc by Fyn in cytosol
Grb2-Sos-Ras-Raf signaling
event
IEV:0000602
Raf activation signaling (through Grb2 and Sos)
IMR:0000340
IMR:0000435
PubMed:15220003
event
IEV:0000603
Binding of Grb2 and Sos in cytosol
IMR:0000290
IMR:0000435
IMR:0001354
IMR:0001357
PubMed:15220003
event
IEV:0000604
GDP-GTP exchange of Ras by Sos in cytosol
event
IEV:0000605
GDP-GTP exchange in cytosol
event
IEV:0000606
GDP-GTP exchange in unidentified cellular location
event
IEV:0000607
Transference in cytosol
IMR:0000231
IMR:0000290
IMR:0001354
event
IEV:0000608
Activation of Raf by Ras-GTP in cytosol
IMR:0000265
IMR:0000290
IMR:0001354
event
IEV:0000609
Binding of Ras-GTP and PI3K in cytosol
event
IEV:0000610
Regulation of integrin signaling pathway
event
IEV:0000611
Negative regulation of integrin signaling pathway
event
IEV:0000612
Positive regulation of integrin signaling pathway
IMR:0000218
IMR:0100701
event
IEV:0000613
Dephosphorylation of FAK by PTEN in cytosol
IMR:0000340
IMR:0000347
event
IEV:0000614
Binding of Shc_p and Grb2 in cytosol
KEGG:hsa04510
event
IEV:0000615
Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
KEGG:hsa04510
KEGG:hsa04810
KEGG:mmu04810
KEGG:rno04810
event
IEV:0000616
Integrin signaling pathway (through Rho)
IMR:0000218
IMR:0000227
event
IEV:0000617
Phosphorylation of ERK by FAK in cytosol
KEGG:hsa04510
event
IEV:0000618
Integrin signaling pathway (through Rac and JNK cascade)
IMR:0000227
UniProt:Q15746
event
IEV:0000619
Activation of MLCK by ERK_p in cytosol
IMR:0000172
UniProt:Q13418
event
IEV:0000620
Binding of integrin complex and Ilk in cytosol
PI3K approaching to the plasma membrane
IMR:0000218
IMR:0000265
event
IEV:0000621
Binding of FAK and PI3K in cytosol
PI3K approaching to the plasma membrane
XX:<new dbxref>
IMR:0000250
IMR:0001352
event
IEV:0000622
Binding of PIP3 and AKT
IMR:0000250
UniProt:Q13418
event
IEV:0000623
Phosphorylation of AKT by IlK in cytosol
event
IEV:0000624
Phosphorylation outside the mitochondria membrane
IMR:0000255
IMR:0001352
event
IEV:0000625
Binding of PIP3 and PDK1
IMR:0000222
IMR:0000434
PubMed:9843681
event
IEV:0000626
Phosphorylation of Vav by Syk in cytosol
IMR:0000297
IMR:0000434
IMR:0001354
IMR:0001357
PubMed:12818159
PubMed:15343367
event
IEV:0000627
GDP-GTP exchange of Rac by Vav in cytosol
IMR:0000238
IMR:0000297
event
IEV:0000628
Activation of PAK by Rac in cytosol
IMR:0000229
IMR:0000238
event
IEV:0000629
Phosphorylation of MAPKKK by PAK in cytosol
IMR:0000335
IMR:0000436
PubMed:11804588
event
IEV:0000630
Binding of Crk and C3G in cytosol
IMR:0000436
IMR:0001354
IMR:0001357
IMR:0001504
PubMed:9560161
event
IEV:0000631
GDP-GTP exchange of Rap1 by C3G in cytosol
IMR:0001504
IMR:0100207
event
IEV:0000632
Activation of MAPKKKK by Rap1 in cytosol
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase.
GO:0000185
GO:0042655
IMR:0000229
IMR:0100207
activation of MAP kinase kinase kinase
activation of MAPKKK activity
event
IEV:0000633
Phosphorylation of MAPKKK by MAPKKKK in cytosol
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase.
GO:0000185
IMR:0000297
IMR:0001354
IMR:0001357
IMR:0001468
event
IEV:0000634
GDP-GTP exchange of Rac by Dock180 in cytosol
IMR:0001468
PubMed:12879077
UniProt:P84095
UniProt:Q92556
UniProt:Q96JJ3
event
IEV:0000635
Complex formation of RhoG, Elmo and Dock180 in cytosol
IMR:0001350
UniProt:P06396
event
IEV:0000636
Binding of PIP2 and gelsolin in cytosol
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
GO:0008154
event
IEV:0000637
Actin polymerization and/or depolymerization
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
GO:0008154
Disassembly of actin filaments by the removal of actin monomers from a filament.
GO:0030042
Actin depolymerization
event
IEV:0000638
Actin filament depolymerization
Disassembly of actin filaments by the removal of actin monomers from a filament.
GO:0030042
Assembly of actin filaments by the addition of actin monomers to a filament.
GO:0030041
Actin polymerization
event
IEV:0000639
Actin filament polymerization
Assembly of actin filaments by the addition of actin monomers to a filament.
GO:0030041
IMR:0000194
IMR:0001350
event
IEV:0000640
Binding of PIP2 and profilin in cytosol
IMR:0001350
UniProt:P23528
UniProt:Q9Y281
event
IEV:0000641
Binding of PIP2 and cofilin in cytosol
IMR:0000189
IMR:0001350
event
IEV:0000642
Binding of PIP2 and actinin in cytosol
IMR:0001350
IMR:0001711
PubMed:8632828
event
IEV:0000643
Binding of PIP2 and vinculin in cytosol
IMR:0001711
IMR:0001714
PubMed:8632828
event
IEV:0000644
Binding of vinculin and talin in cytosol
IMR:0001093
IMR:0001350
event
IEV:0000645
Binding of PIP2 and ERM in cytosol
IMR:0001093
IMR:0001350
PubMed:12045227
PubMed:8858161
event
IEV:0000646
Activation of ERM by PIP2 in cytosol
IMR:0000268
IMR:0000296
PubMed:7954816
event
IEV:0000647
Activation of PI5K by Rho in cytosol
Inhibitor of p160ROCK
event
IEV:0000648
Y-27632 medication
Inhibitor of p160ROCK
XX:<new dbxref>
IMR:0000296
UniProt:Q13464
event
IEV:0000649
Activation of p160ROCK by Rho in cytosol
Inactivation of myosin phosphatase
PubMed:8662509
UniProt:Q13464
event
IEV:0000650
Phosphorylation of myosin phosphatase by p160ROCK in cytosol
Inactivation of myosin phosphatase
XX:<new dbxref>
IMR:0000191
UniProt:Q15746
event
IEV:0000651
Phosphorylation of MLC by MLCK in cytosol
UniProt:P53667
UniProt:Q13464
event
IEV:0000652
Phosphorylation of LIM-kinase by p160ROCK in cytosol
PubMed:9655398
UniProt:P23528
UniProt:P53667
UniProt:Q9Y281
event
IEV:0000653
Phosphorylation of cofilin by LIM-kinase in cytosol
IMR:0000227
PubMed:9128257
UniProt:Q15746
event
IEV:0000654
Phosphorylation of MLCK by ERK in cytosol
event
IEV:0000655
Regulation of Integrin signaling pathway (through Rho)
event
IEV:0000656
Negative regulation of Integrin signaling pathway (through Rho)
event
IEV:0000657
Positive regulation of Integrin signaling pathway (through Rho)
IMR:0000238
PubMed:10092231
UniProt:Q15746
event
IEV:0000658
Phosphorylation of MLCK by PAK in cytosol
KEGG:hsa04510
KEGG:hsa04810
KEGG:mmu04810
KEGG:rno04810
event
IEV:0000659
Rac/Cdc42-PAK-MLCK signaling
IMR:0000238
IMR:0000699
event
IEV:0000660
Activation of PAK by Cdc42 in cytosol
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
GO:0007186
G-protein coupled receptor protein signaling pathway
event
IEV:0000661
GPCR signaling pathway
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
GO:0007186
IMR:0000137
PubMed:14734786
event
IEV:0000662
Binding of GPCR ligand and GPCR in extracellular
IMR:0000316
IMR:0001354
IMR:0001357
event
IEV:0000663
GDP-GTP exchange of G alpha in cytosol
IMR:0000316
IMR:0001354
IMR:0100018
event
IEV:0000664
Dissociation of G alpha-GTP and G beta:G gamma in cytosol
event
IEV:0000665
Dissociation in plasma membrane
IMR:0000316
IMR:0001354
event
IEV:0000666
Binding of G alpha-GTP and effector in cytosol
IMR:0100018
PubMed:14734786
event
IEV:0000667
Binding of G beta:G gamma and effector in cytosol
event
IEV:0000668
Regulation of heterotrimeric GPCR signaling pathway
event
IEV:0000669
Negative regulation of heterotrimeric GPCR signaling pathway
event
IEV:0000670
Positive regulation of heterotrimeric GPCR signaling pathway
event
IEV:0000671
G alpha-GTP hydrolysis signaling
IMR:0001354
event
IEV:0000672
Hydrolysis of GTP by G alpha-GTP in cytosol
event
IEV:0000673
Hydrolysis in unidentified cellular location
IMR:0000316
IMR:0000431
IMR:0001354
event
IEV:0000674
Binding of G alpha-GTP and RGS in cytosol
IMR:0000316
IMR:0001357
event
IEV:0000675
Dissociation of G alpha-GDP and target protein in cytosol
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
GO:0007264
small GTPase mediated signal transduction
event
IEV:0000676
Small GTPase mediated signaling
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
GO:0007264
small GTPase mediated signal transduction
GO:0007264
event
IEV:0000677
GDP-GTP exchange of small GTPase by GEF
true
event
IEV:0000678
Binding of small GTPase-GTP and target protein
true
IMR:0000288
IMR:0000442
IMR:0001354
event
IEV:0000679
Binding of small GTPase-GTP and GAP in cytosol
IMR:0000288
IMR:0001354
event
IEV:0000680
Hydrolysis of GTP by small GTPase in cytosol
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051056
regulation of small GTPase mediated signal transduction
event
IEV:0000681
Regulation of small GTPase mediated signaling
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051056
regulation of small GTPase mediated signal transduction
GO:0051056
Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051057
positive regulation of small GTPase mediated signal transduction
event
IEV:0000682
Positive regulation of small GTPase mediated signaling
Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051057
positive regulation of small GTPase mediated signal transduction
GO:0051057
Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051058
negative regulation of small GTPase mediated signal transduction
event
IEV:0000683
Negative regulation of small GTPase mediated signaling
Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction.
GO:0051058
negative regulation of small GTPase mediated signal transduction
GO:0051058
event
IEV:0000684
Small GTPase hydrolysis signaling
event
IEV:0000685
Hydrolysis in cytosol
IMR:0000313
IMR:0001354
IMR:0100366
PubMed:14734786
event
IEV:0000686
Inactivation of ACs.
Binding of G alpha s-GTP and adenylate cyclase in cytosol
The formation from simpler components of cyclic AMP, adenosine 3',5'-phosphate.
GO:0006171
IMR:0000313
IMR:0001351
IMR:0100024
PubMed:7814360
event
IEV:0000687
Hydrolysis of ATP to cAMP by adenylate cyclase in cytosol
The formation from simpler components of cyclic AMP, adenosine 3',5'-phosphate.
GO:0006171
IMR:0000313
IMR:0001357
IMR:0100366
PubMed:11604548
event
IEV:0000688
Dissociation of G alpha s-GDP and adenylate cyclase in cytosol
IMR:0000313
IMR:0000319
IMR:0001354
PubMed:14734786
event
IEV:0000689
Binding of G alpha i-GTP and adenylate cyclase in cytosol
IMR:0000313
IMR:0000319
IMR:0001357
event
IEV:0000690
Dissociation of G alpha i-GDP and adenylate cyclase in cytosol
GO:0007189
PubMed:14734786
event
IEV:0000691
Heterotrimeric GPCR signaling pathway (through G alpha s)
IEV:0000716
Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin)
event
IEV:0000692
Heterotrimeric GPCR signaling pathway (through G alpha i)
event
IEV:0000693
Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
event
IEV:0000694
Negative regulation of (G alpha i GDP-GTP exchange signaling)
event
IEV:0000695
Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
event
IEV:0000696
Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
IMR:0000319
IMR:0000431
IMR:0001354
PubMed:8774883
event
IEV:0000697
Binding of G alpha i-GTP and RGS in cytosol
IMR:0000431
IMR:0001354
PubMed:8774883
event
IEV:0000698
Hydrolysis of GTP by G alpha i-GTP and RGS in cytosol
IMR:0000431
IMR:0001354
IMR:0100366
PubMed:11604548
event
IEV:0000699
Binding of G alpha s-GTP and RGS in cytosol
IMR:0000431
IMR:0001354
PubMed:11604548
event
IEV:0000700
Hydrolysis of GTP by G alpha s-GTP and RGS in cytosol
PubMed:8774883
event
IEV:0000701
G alpha i-GTP hydrolysis signaling
PubMed:11604548
G alpha s inactivation signaling
event
IEV:0000702
G alpha s-GTP hydrolysis signaling
event
IEV:0000703
Ras-GTP hydrolysis signaling
Any process that stops, prevents or reduces the rate, frequency or extent of Ras protein signal transduction.
GO:0046580
negative regulation of Ras protein signal transduction
event
IEV:0000704
Negative regulation of Ras mediated signaling
Any process that stops, prevents or reduces the rate, frequency or extent of Ras protein signal transduction.
GO:0046580
negative regulation of Ras protein signal transduction
GO:0046580
IMR:0000290
IMR:0001354
event
IEV:0000705
Hydrolysis of GTP by Ras in cytosol
IMR:0000290
IMR:0000442
IMR:0001354
event
IEV:0000706
Binding of Ras-GTP and GAP in cytosol
event
IEV:0000707
Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
IMR:0100366
IMR:0100468
event
IEV:0000708
ADP-ribosylation of G alpha s by cholera toxin in cytosol
Reaction that can affect Arg, Cys, Glu, Arg and Asn residues.
EC:2.4.5.30
EC:2.4.5.31
EC:2.4.5.36
EC:2.4.5.37
MI:0557
event
IEV:0000709
ADP ribosylation
Reaction that can affect Arg, Cys, Glu, Arg and Asn residues.
MI:0557
event
IEV:0000710
ADP ribosylation in cytosol
event
IEV:0000711
ADP ribosylation in plasma membrane
event
IEV:0000712
Transference in unidentified cellular location
IMR:0000313
IMR:0001354
IMR:0100366
event
IEV:0000713
Binding of G alpha s-GTP-ADPrib and adenylate cyclase in cytosol
event
IEV:0000714
Clinical presentation
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
MeSH:D003967
event
IEV:0000715
Diarrhea
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
MeSH:D003967
true
A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.
MeSH:D014917
event
IEV:0000717
Whooping cough
A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.
MeSH:D014917
IMR:0000319
IMR:0100469
PubMed:9032437
event
IEV:0000718
ADP ribosylation of G alpha i by pertussis toxin in cytosol
IMR:0000319
IMR:0001354
IMR:0100018
event
IEV:0000719
Dissociation of G alpha i-GTP and G beta:G gamma in cytosol
IMR:0000319
IMR:0001354
IMR:0001357
PubMed:14734786
event
IEV:0000720
GDP-GTP exchange of G alpha i in cytosol
IMR:0001354
IMR:0100018
IMR:0100366
PubMed:14734786
event
IEV:0000721
Dissociation of G alpha s-GTP and G beta:G gamma in cytosol
IMR:0000317
IMR:0001354
IMR:0001357
PubMed:14734786
event
IEV:0000722
GDP-GTP exchange of G alpha s in cytosol
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon.
GO:0030265
event
IEV:0000723
Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon.
GO:0016056
UniProt:P08100
event
IEV:0000724
Activation of rhodopsin by photon in extracellular
event
IEV:0000725
Activation in extracellular
IMR:0000321
IMR:0001354
IMR:0001357
PubMed:14734786
event
IEV:0000726
GDP-GTP exchange of G alpha t in cytosol
IMR:0000321
IMR:0001354
IMR:0100018
event
IEV:0000727
Dissociation of G alpha t-GTP and G beta:G gamma in cytosol
IMR:0000321
IMR:0001022
IMR:0001354
event
IEV:0000728
Binding of G alpha t-GTP and cGMP PDE in cytosol
IMR:0001022
IMR:0100025
IMR:0200292
event
IEV:0000729
Hydrolysis of cGMP to GMP by cGMP PDE in cytosol
event
IEV:0000730
Regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
event
IEV:0000731
Regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
event
IEV:0000732
Regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
event
IEV:0000733
Negative regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
event
IEV:0000734
Positive regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
event
IEV:0000735
G alpha t-GTP hydrolysis signaling
IMR:0000321
IMR:0000431
IMR:0001354
event
IEV:0000736
Binding of G alpha t-GTP and RGS in cytosol
IMR:0000321
IMR:0001022
IMR:0001357
event
IEV:0000737
Dissociation of G alpha t-GDP and cGMP PDE in cytosol
IMR:0000431
IMR:0001354
event
IEV:0000738
Hydrolysis of GTP by G alpha t-GTP and RGS in cytosol
The directed movement of charged atoms or small charged molecules into, out of, within or between cells.
GO:0006811
ion transport
event
IEV:0000739
Ion transport through ion channel
The directed movement of charged atoms or small charged molecules into, out of, within or between cells.
GO:0006811
IMR:0000498
IMR:0001658
event
IEV:0000740
Cation ion transport from extracellular to cytosol through cation channel
IMR:0001354
IMR:0001357
IMR:0100378
PubMed:14734786
event
IEV:0000741
GDP-GTP exchange of G alpha q in cytosol
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
GO:0007601
event
IEV:0000742
Visual perception
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
GO:0007601
event
IEV:0000743
Changes in polarization state of photoreceptor cell membrane
The processes pertaining to the functions of the nervous system of an organism.
GO:0050877
Neurological process
Neurophysiological process
event
IEV:0000744
Neurological system process
The processes pertaining to the functions of the nervous system of an organism.
GO:0050877
Neurophysiological process
GO:0050877
The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
GO:0007269
neurotransmitter release
event
IEV:0000745
Neurotransmitter secretion
The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
GO:0007269
Process by which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation.
GO:0016062
event
IEV:0000746
Adaptation of rhodopsin mediated signaling
Process by which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation.
GO:0016062
The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon).
GO:0016059
event
IEV:0000747
Deactivation of rhodopsin mediated signaling
The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon).
GO:0016059
GO:0007200
event
IEV:0000748
Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
GO:0007201
IMR:0001354
IMR:0100018
IMR:0100378
event
IEV:0000749
Dissociation of G alpha q-GTP and G beta:G gamma in cytosol
IMR:0000286
IMR:0001354
IMR:0100378
PubMed:14734786
event
IEV:0000750
Binding of G alpha q-GTP and PLC beta in cytosol
event
IEV:0000751
Regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
event
IEV:0000752
Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
event
IEV:0000753
Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
event
IEV:0000754
G alpha q-GTP hydrolysis signaling
IMR:0000431
IMR:0001354
IMR:0100378
event
IEV:0000755
Binding of G alpha q-GTP and RGS in cytosol
IMR:0000286
IMR:0001357
IMR:0100378
event
IEV:0000756
Dissociation of G alpha q-GDP and PLC beta in cytosol
IMR:0000431
IMR:0001354
IMR:0100378
event
IEV:0000757
Hydrolysis of GTP by G alpha q-GTP and RGS in cytosol
event
IEV:0000758
Rhodopsin dark adaptation
event
IEV:0000759
Rhodopsin dark adaptation signaling
UniProt:P08100
event
IEV:0000760
Inactivation of Rhodopsin in extracellular
IMR:0100712
PubMed:14985712
event
IEV:0000761
Nuclear import of Notch (NIC) from the cytosol
event
IEV:0000762
Channel opening/closing in the plasma membrane
IMR:0100003
IMR:0100025
event
IEV:0000763
Binding of cGMP and cGMP activated cation ion channel and the channel opening in cytosol
IMR:0100003
IMR:0100025
event
IEV:0000764
Dissociation of cGMP and cGMP activated cation ion channel and the channel closing in cytosol
IMR:0000084
IMR:0100028
event
IEV:0000765
Dissociation of IP3 and IP3R and IP3R closing
IMR:0000321
IMR:0001357
IMR:0100018
event
IEV:0000766
Binding of G alpha t-GDP and G beta:G gamma in cytosol
event
IEV:0000767
Channel opening/closing
event
IEV:0000768
Hyper polarization state of photoreceptor cell membrane
event
IEV:0000769
Depolarization state of photoreceptor cell membrane
event
IEV:0000770
Channel opening/closing in the ER membrane
event
IEV:0000771
Change in material concentration
Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger.
GO:0051482
elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)
event
IEV:0000772
Cytosolic calcium ion concentration elevation (through IP3 receptor)
Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger.
GO:0051482
event
IEV:0000773
Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
IEV:0001334
GO:0007623
KEGG:hsa04710
KEGG:mmu04710
KEGG:rno04710
Circadian process
Response to circadian rhythm
event
IEV:0000774
Circadian rhythm
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
GO:0007623
GO:0001664
GO:0008502
IMR:0100069
UniProt:P48039
UniProt:P49286
event
IEV:0000775
part_of: Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o, PLCbeta and circadian rhythm)
Binding of melatonin and melatonin receptor in cytosol
IMR:0000320
IMR:0001354
IMR:0001357
PubMed:14734786
event
IEV:0000776
GDP-GTP exchange of G alpha o in cytosol
IMR:0000320
IMR:0001354
IMR:0100018
event
IEV:0000777
Dissociation of G alpha o-GTP and G beta:G gamma in cytosol
IMR:0000286
IMR:0000320
IMR:0001354
PubMed:14734786
event
IEV:0000778
Binding of G alpha o-GTP and PLC beta in cytosol
The series of molecular signals that results in the upregulation of protein kinase C activity in response to the signal.
GO:0007205
PKC activation
protein kinase C activation
event
IEV:0000779
PKC activation signaling
The series of molecular signals that results in the upregulation of protein kinase C activity in response to the signal.
GO:0007205
PKC activation
GO:0007205
protein kinase C activation
GO:0007205
PubMed:14734786
event
IEV:0000780
PKA activation signaling
true
TNFR1 signaling
GO:0007250
IMR:0000243
IMR:0100451
event
IEV:0000782
Phosphorylation of IKK complex by MEKK3 in cytosol
TNFR1 signaling
XX:<new dbxref>
IMR:0000382
event
IEV:0000783
Gene expression by NF-kappaB
Toll-like receptor pathway
IMR:0000232
IMR:0000243
PubMed:15125833
Phosphorylation of DmIKK by TAK1 [Drosophila]
event
IEV:0000784
Phosphorylation of IKK complex by TAK1 in cytosol
Toll-like receptor pathway
XX:<new dbxref>
event
IEV:0000785
Regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
event
IEV:0000786
Negative regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
event
IEV:0000787
Positive regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK- NF-kappaB cascade)
IMR:0000089
IMR:0100446
PubMed:14587029
event
IEV:0000788
Binding of RelA and PPAR in inner space of nucleus
KEGG:hsa03320
peroxisome proliferator-activated receptor signaling
event
IEV:0000789
PPAR signaling
IMR:0000002
IMR:0000089
event
IEV:0000790
Binding of ligand and PPAR in cytosol
event
IEV:0000791
Binding outside the nuclear membrane
IMR:0000085
IMR:0000089
event
IEV:0000792
Binding of PPAR and nuclear receptor in inner space of nucleus
IGS:0000015
IMR:0000089
event
IEV:0000793
Binding of PPAR and PPRE in inner space of nucleus
IMR:0000089
KEGG:C00162
event
IEV:0000794
Binding of fatty acid and PPAR in cytosol
IMR:0000089
IMR:0000368
event
IEV:0000795
Binding of PPAR and transcription factor in inner space of nucleus
IMR:0000089
UniProt:P19793
UniProt:P28702
event
IEV:0000796
Binding of PPAR and RXR in inner space of nucleus
IMR:0000089
event
IEV:0000797
Phosphorylation of PPAR by kinase in cytosol
event
IEV:0000798
Regulation of PPAR signaling
event
IEV:0000799
Negative regulation of PPAR signaling
event
IEV:0000800
Positive regulation of PPAR signaling
IMR:0000089
IMR:0000517
event
IEV:0000801
Dephosphorylation of PPAR by phosphatase in cytosol
event
IEV:0000802
TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
IMR:0000061
TNFR2 trimerization
event
IEV:0000803
Trimerization of TNFR2 in plasma membrane
IMR:0000025
IMR:0000061
event
IEV:0000804
Binding of TNF alpha homotrimer and TNFR2 in extracellular
IMR:0000061
IMR:0100423
event
IEV:0000805
Binding of TNFR2 and TRAF2 in cytosol
IMR:0000061
IMR:0100422
event
IEV:0000806
Binding of TNFR2 and TRAF1 in cytosol
IMR:0000269
IMR:0100222
event
IEV:0000807
Activation of MEKK1 by RIP in cytosol
IMR:0000242
IMR:0000269
event
IEV:0000808
Activation of NIK by RIP in cytosol
IMR:0000242
IMR:0100222
event
IEV:0000809
Phosphorylation of MEKK1 by NIK in cytosol
GO:0007250
IMR:0000243
IMR:0100222
event
IEV:0000810
Phosphorylation of IKK complex by MEKK1 in cytosol
TNFR1 signaling
GO:0007256
IMR:0000262
IMR:0100218
event
IEV:0000811
Phosphorylation of MKK4/7 by ASK1 in cytosol
TNFR1 signaling
XX:<new dbxref>
IMR:0000032
IMR:0000068
event
IEV:0000812
Binding of PDGF and PDGF receptor in extracellular
IMR:0000068
PDGF receptor dimerization
event
IEV:0000813
Dimerization of PDGF receptor in plasma membrane
IMR:0000068
event
IEV:0000814
Autophosphorylation of PDGF receptor in plasma membrane
IEV:0002452
IMR:0000068
IMR:0000340
Binding of (PDGF:PDGF Receptor_p) and (GRB2:SOS)
event
IEV:0000815
Binding of PDGF receptor and Grb2 in cytosol
IMR:0000068
IMR:0000347
event
IEV:0000816
Binding of PDGF receptor and Shc in cytosol
IMR:0000813
IMR:0001094
event
IEV:0000817
Transcription of c-fos by Elk-1 in nucleus
event
IEV:0000818
Metabolic pathway
PDGF signaling
IMR:0000227
IMR:0001094
event
IEV:0000819
Phosphorylation of Elk-1 by ERK_p in inner space of nucleus
PDGF signaling
XX:<new dbxref>
PDGF signaling, Integrin signaling, G
IMR:0000231
IMR:0000261
PubMed:11752597
event
IEV:0000820
Phosphorylation of MEK1/2(MKK1/2) by Raf in cytosol
PDGF signaling, Integrin signaling, G
XX:<new dbxref>
event
IEV:0000821
Regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
event
IEV:0000822
Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
event
IEV:0000823
Positive regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
IMR:0000290
IMR:0001357
event
IEV:0000824
Dissociation of Ras-GDP and target protein in cytosol
event
IEV:0000825
PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
event
IEV:0000826
RalGDS-Ral-RalBP1 signaling
IMR:0000290
IMR:0001354
IMR:0100433
event
IEV:0000827
Binding of Ras-GTP and RalGDS in cytosol
IMR:0000293
IMR:0001354
IMR:0001357
IMR:0100433
event
IEV:0000828
GDP-GTP exchange of Ral by RalGDS in cytosol
Activation of RalBP1 by Ral-GTP
IMR:0000293
IMR:0001354
UniProt:Q15311
event
IEV:0000829
Binding of Ral-GTP and RalBP1 in cytosol
Activation of RalBP1 by Ral-GTP
XX:<new dbxref>
The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand.
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
event
IEV:0000830
RTK signaling pathway
The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand.
GO:0007169
IMR:0000265
IMR:0002063
PubMed:12515821
UniProt:Q12929
UniProt:Q8IZP0
event
IEV:0000831
Complex formation of PI3K, Eps8, Abi1 and Sos1 in cytosol
IMR:0000297
IMR:0001354
IMR:0001357
IMR:0002063
PubMed:12515821
event
IEV:0000832
GDP-GTP exchange of Rac by Sos1 in cytosol
PubMed:12515821
event
IEV:0000833
Rac activation signaling (through PI3K)
event
IEV:0000834
Regulation of RTK signaling pathway
event
IEV:0000835
Negative regulation of RTK signaling pathway
event
IEV:0000836
Positive regulation of RTK signaling pathway
IMR:0000297
IMR:0000382
IMR:0001354
PubMed:10740269
NF-kappaB activation
event
IEV:0000837
Activation of NF-kappaB by Rac-GTP in cytosol
IMR:0000382
event
IEV:0000838
Gene expression of anti-apoptotic gene by NF-kappaB
event
IEV:0000839
Regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
event
IEV:0000840
Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
event
IEV:0000841
Positive regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
IMR:0000030
IMR:0000063
event
IEV:0000842
Binding of RTK-ligand and RTK in extracellular
GO:0004714
IMR:0000063
event
IEV:0000843
Autophosphorylation of RTK in plasma membrane
IMR:0000063
IMR:0000340
event
IEV:0000844
Binding of RTK and Grb2 in cytosol
IMR:0000063
IMR:0000347
event
IEV:0000845
Binding of RTK and Shc in cytosol
GO:0007171
IMR:0000063
RTK dimerization
transmembrane receptor protein tyrosine kinase activation (dimerization)
event
IEV:0000846
Dimerization of RTK in plasma membrane
event
IEV:0000847
RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
Grb2-Sos-Ras-RalGDS signaling
event
IEV:0000848
RalGDS activation signaling (through Grb2 and Sos)
IMR:0000290
IMR:0001354
IMR:0100433
event
IEV:0000849
Activation of RalGDS by Ras-GTP in cytosol
event
IEV:0000850
Rac-GTP hydrolysis signaling
IMR:0000297
IMR:0001354
event
IEV:0000851
Hydrolysis of GTP by Rac in cytosol
IMR:0000297
IMR:0001357
event
IEV:0000852
Dissociation of Rac-GDP and target protein in cytosol
event
IEV:0000853
Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
event
IEV:0000854
Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
event
IEV:0000855
Positive regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
event
IEV:0000856
RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
event
IEV:0000857
RalGDS-Ral-PLD1 signaling
IMR:0000293
IMR:0000728
IMR:0001354
event
IEV:0000858
Binding of Ral-GTP and Phospholipase D1 in cytosol
IMR:0000728
KEGG:C00416
event
IEV:0000859
Hydrolysis of phosphatidic acid by PLD1 in cytosol
event
IEV:0000860
Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
event
IEV:0000861
Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
event
IEV:0000862
Positive regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor.
GO:0030509
BMP receptor signaling pathway
event
IEV:0000863
BMP signaling pathway
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor.
GO:0030509
BMP receptor signaling pathway
GO:0030509
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands.
GO:0007179
KEGG:hsa04350
transforming growth factor beta receptor signaling pathway
event
IEV:0000864
TGF beta signaling pathway
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands.
GO:0007179
transforming growth factor beta receptor signaling pathway
GO:0007179
The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
GO:0007173
EGF signaling pathway
EGFR signaling pathway
epidermal growth factor receptor signaling pathway
event
IEV:0000865
EGF receptor signaling pathway
The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
GO:0007173
EGF signaling pathway
GO:0007173
EGFR signaling pathway
GO:0007173
epidermal growth factor receptor signaling pathway
GO:0007173
The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands.
GO:0048011
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
NGF signaling pathway
nerve growth factor receptor signaling pathway
event
IEV:0000866
NGF receptor signaling pathway
The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands.
GO:0048011
NGF signaling pathway
GO:0048011
nerve growth factor receptor signaling pathway
GO:0048011
event
IEV:0000867
EPO signaling pathway
PubMed:10721693
event
IEV:0000868
p53 degradation signaling
IMR:0100659
IMR:0100660
PubMed:10721693
PubMed:15021897
event
IEV:0000869
Ubiquitination of p53 by Mdm2 in nucleus
IMR:0100660
IMR:0701010
PubMed:15021897
event
IEV:0000870
Binding of Mdm2 and p19ARF in inner space of nucleus
event
IEV:0000871
Ubiquitination in nucleus
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0006281
MeSH:D004260
event
IEV:0000872
DNA repair
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0006281
Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.
GO:0017015
event
IEV:0000873
Regulation of TGF beta signaling pathway
Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.
GO:0017015
Any process that stops, prevents or reduces the rate, frequency or extent of any TGFbeta receptor signaling pathway.
GO:0030512
event
IEV:0000874
Negative regulation of TGF beta signaling pathway
Any process that stops, prevents or reduces the rate, frequency or extent of any TGFbeta receptor signaling pathway.
GO:0030512
Any process that activates or increases the rate, frequency or extent of TGFbeta receptor signaling pathway activity.
GO:0030511
event
IEV:0000875
Positive regulation of TGF beta signaling pathway
Any process that activates or increases the rate, frequency or extent of TGFbeta receptor signaling pathway activity.
GO:0030511
event
IEV:0000876
Regulation of TGF beta super family signaling pathway (through p38 cascade)
event
IEV:0000877
Negative regulation of TGF beta super family signaling pathway (through p38 cascade)
event
IEV:0000878
Positive regulation of TGF beta super family signaling pathway (through p38 cascade)
event
IEV:0000879
Regulation of TGF beta super family signaling pathway
event
IEV:0000880
Negative regulation of TGF beta super family signaling pathway
event
IEV:0000881
Positive regulation of TGF beta super family signaling pathway
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
GO:0030510
event
IEV:0000882
Regulation of BMP signaling pathway
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
GO:0030510
Any process that stops, prevents or reduces the rate, frequency or extent of BMP signaling pathway activity.
GO:0030514
event
IEV:0000883
Negative regulation of BMP signaling pathway
Any process that stops, prevents or reduces the rate, frequency or extent of BMP signaling pathway activity.
GO:0030514
Any process that activates or increases the rate, frequency or extent of BMP signaling pathway activity.
GO:0030513
event
IEV:0000884
Positive regulation of BMP signaling pathway
Any process that activates or increases the rate, frequency or extent of BMP signaling pathway activity.
GO:0030513
Negative feedback regulation pathway of TGF beta superfamily signaling pathway
event
IEV:0000885
Negative feedback regulation pathway of TGF beta superfamily signaling
IMR:0000371
IMR:0000373
IMR:0100315
Gene expression of Smad6/7 by R-Smad:Smad4
event
IEV:0000886
Gene expression of I-Smad by R-Smad:Smad4
IMR:0000373
IMR:0000710
Binding of Smad6/7 and TGF beta receptor I in cytosol
event
IEV:0000887
Binding of I-Smad and TGF beta receptor I in cytosol
IMR:0000224
IMR:0000371
IMR:0100315
PubMed:11752591
event
IEV:0000888
Phosphorylation of R-Smad:Smad4 by MAPK in cytosol
PubMed:11163210
event
IEV:0000889
TGF beta receptor I degradation signaling
IMR:0100318
IMR:0100514
PubMed:11163210
event
IEV:0000890
Complex formation of Smad7 and smurf2 in cytosol
IMR:0000710
IMR:0100318
IMR:0100514
PubMed:11163210
event
IEV:0000891
Binding of Smad7:smurf2 and TGF beta type I receptor in cytosol
IMR:0000710
IMR:0100514
PubMed:11163210
event
IEV:0000892
Ubiquitination of TGF beta receptor I by smurf2 in cytosol
IMR:0000310
IMR:0000710
PubMed:11163210
event
IEV:0000893
Proteasome degradation of TGF beta receptor I by 26S proteasome in plasma membrane
IMR:0000710
IMR:0100318
IMR:0100514
PubMed:11163210
event
IEV:0000894
Dissociation of Smad7:smurf2 and TGF beta receptor I_Ub in cytosol
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
GO:0030579
ubiquitin-dependent SMAD protein breakdown
ubiquitin-dependent SMAD protein catabolic process
ubiquitin-dependent SMAD protein catabolism
ubiquitin-dependent SMAD protein degradation
event
IEV:0000895
R-Smad degradation signaling
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
GO:0030579
IMR:0000371
IMR:0100318
IMR:0100513
IMR:0100514
event
IEV:0000896
Binding of Smad7:smurf1/2 and R-Smad in cytosol
IMR:0000371
IMR:0100513
IMR:0100514
event
IEV:0000897
Ubiquitination of R-Smad_Ub by smurf1/2 in cytosol
IMR:0000371
IMR:0100318
IMR:0100513
IMR:0100514
event
IEV:0000898
Dissociation of Smad7:smurf1/2 and R-Smad_Ub in cytosol
IMR:0000310
IMR:0000371
event
IEV:0000899
Proteasome degradation of R-Smad by 26S proteasome in cytosol
IMR:0000373
Nuclear export of mRNA (Smad6/7)
event
IEV:0000900
Nuclear export of mRNA (I-Smad)
IMR:0000371
IMR:0000373
IMR:0100315
Transcription of Smad6/7 by R-Smad:Smad4 in nucleus
event
IEV:0000901
Transcription of I-Smad by R-Smad:Smad4 in nucleus
IMR:0000373
Translation of Smad6/7 in cytosol
event
IEV:0000902
Translation of I-Smad in cytosol
IMR:0000093
IMR:0000373
Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of Smad6/7 and TGF beta receptor I)
event
IEV:0000903
Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of I-Smad and TGF beta receptor I)
IMR:0000371
IMR:0100513
IMR:0100514
event
IEV:0000904
Negative feedback regulation pathway of TGF beta superfamily signaling by (R-Smad degradation through smurf1/2)
IMR:0000093
IMR:0000094
event
IEV:0000905
Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)
IMR:0000371
IMR:0100315
IMR:0100318
event
IEV:0000906
Gene expression of Smad7 by R-Smad:Smad4
IMR:0000371
IMR:0100315
IMR:0100318
event
IEV:0000907
Transcription of Smad7 by R-Smad:Smad4 in nucleus
IMR:0100318
event
IEV:0000908
Translation of Smad7 in cytosol
The directed movement of mRNA from the nucleus to the cytoplasm.
GO:0006406
mRNA export from nucleus
mRNA export out of nucleus
mRNA transport from nucleus to cytoplasm
mRNA-nucleus export
event
IEV:0000909
Nuclear export of mRNA
The directed movement of mRNA from the nucleus to the cytoplasm.
GO:0006406
REACT:402.1
TRAIL signaling
event
IEV:0000910
DR4/5 signaling pathway
event
IEV:0000911
DR3 signaling pathway
EC:6 catalyzed process
EC:6.-.-.-
GO:0016874
event
IEV:0000912
Ligation
EC:6 catalyzed process
EC:6.-.-.-
EC:2 catalyzed process
EC:2.-.-.-
GO:0016740
event
IEV:0000913
Transference
EC:2 catalyzed process
EC:2.-.-.-
EC:1 catalyzed process
EC:1.-.-.-
GO:0016491
event
IEV:0000914
Oxidation/Reduction
EC:1 catalyzed process
EC:1.-.-.-
EC:5 catalyzed process
EC:5.-.-.-
GO:0016853
event
IEV:0000915
Isomerization
EC:5 catalyzed process
EC:5.-.-.-
event
IEV:0000916
Reduction
EC:4 catalyzed process
[STKE:0456] Enzyme that catalyzes the cleavage of C-C, C-O, C-S, C-N or other bonds by other means than by hydrolysis or oxidation, with two substrates in one reaction direction, and one in the other. In the latter direction, a molecule (of carbon dioxide, water, etc) is eliminated, thus creating a new double bond or a new ring.
[GO:0016829] Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
EC:4.-.-.-
GO:0016829
STKE:0456
event
IEV:0000917
Lyase process
EC:4 catalyzed process
[STKE:0456] Enzyme that catalyzes the cleavage of C-C, C-O, C-S, C-N or other bonds by other means than by hydrolysis or oxidation, with two substrates in one reaction direction, and one in the other. In the latter direction, a molecule (of carbon dioxide, water, etc) is eliminated, thus creating a new double bond or a new ring.
[GO:0016829] Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0016829
STKE:0456
Reversible reaction that can affect C,K,T or S residues.
MI:0216
event
IEV:0000918
Palmitoylation
Reversible reaction that can affect C,K,T or S residues.
MI:0216
Reversible reaction that can affect C residue.
MI:0206
event
IEV:0000919
Farnesylation
Reversible reaction that can affect C residue.
MI:0206
Reversible reaction that can affect C residue.
MI:0209
event
IEV:0000920
Geranylgeranylation
Reversible reaction that can affect C residue.
MI:0209
Polyisoprenylation
event
IEV:0000921
Isoprenylation
true
IMR:0000022
IMR:0010252
REACT:1426.2
FASL binds FAS Receptor
induction of apoptosis by extracellular signals
event
IEV:0000923
Binding of FasL and Fas in extracellular
IMR:0010252
REACT:606.2
Fas trimerization
Trimerization of the FASL:FAS receptor complex
event
IEV:0000924
Trimerization of Fas in plasma membrane
IMR:0010252
IMR:0100463
REACT:2191.3
FasL:Fas binds FADD
event
IEV:0000925
Binding of Fas and FADD in cytosol
IMR:0100300
IMR:0100301
IMR:0100463
REACT:1143.2
REACT:1543.2
DISC complex formation
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
event
IEV:0000926
Binding of FADD and pro-caspase8/10 in cytosol
IMR:0100300
IMR:0100463
REACT:1038.2
REACT:1543.2
DISC complex formation
event
IEV:0000927
Binding of FADD and pro-caspase8 in cytosol
IMR:0100301
IMR:0100463
REACT:1143.2
REACT:1418.2
DISC complex formation
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
event
IEV:0000928
Binding of FADD and pro-caspase10 in cytosol
GO:0006919
event
IEV:0000929
Caspase8/10 activation signaling
IMR:0100300
REACT:1159.2
Caspase8 homodimer formation
Formation of Caspase-8 dimer
event
IEV:0000930
Homodimerization of Caspase8 in cytosol
GO:0006919
IMR:0100300
REACT:832.2
Activation of Pro-Caspase 8
Cleavage of pro-caspase8
event
IEV:0000931
Hydrolysis of pro-caspase8 in cytosol
IMR:0000060
IMR:0000269
IMR:0100423
IMR:0100464
REACT:2175.2
TNF:TNF-R1 binds TRADD, TRAF2 and RIP Complex
event
IEV:0000932
Binding of TNFR1, TRADD, TRAF2 and RIP in cytosol
IMR:0000025
IMR:0000060
IMR:0000269
IMR:0100423
IMR:0100464
REACT:1856.1
TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex
event
IEV:0000933
Dissociation of TRADD:TRAF2:RIP complex and TNF alpha:TNFR1 in cytosol
IMR:0000269
IMR:0100464
event
IEV:0000934
Binding of TRADD and RIP in cytosol
IMR:0001200
IMR:0001201
IMR:0001202
REACT:2170.2
TRAIL Binds TRAIL-Receptor2
event
IEV:0000935
Binding of DR4/5 and APO-2L in extracellular
IMR:0001201
IMR:0001202
REACT:1360.2
DR4/5 trimerization
Trimerization of TRAIL: TRAIL receptor-2 complex
event
IEV:0000936
Trimerization of DR4/5 in plasma membrane
IMR:0001201
IMR:0001202
IMR:0100463
REACT:1721.2
TRAIL:TRAIL receptor-2 Trimer Binds FADD
event
IEV:0000937
Binding of DR4/5 and FADD in cytosol
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
Intrinsic Pathway for Apoptosis
event
IEV:0000938
Caspase cascade (not through mitochondria)
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
REACT:964.2
Intrinsic Pathway for Apoptosis
event
IEV:0000939
Caspase cascade (through mitochondria)
The conversion of proteins that induce or sustain apoptosis to an active form.
GO:0008633
REACT:697.2
activation of pro-apoptotic gene products
event
IEV:0000940
Apoptotic factor activation signaling
The conversion of proteins that induce or sustain apoptosis to an active form.
GO:0008633
GO:0008633
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
REACT:701.2
Activation, myristoylation of BID and translocation to mitochondria
event
IEV:0000941
BID activation signaling
GO:0008633
IMR:0100289
IMR:0100300
REACT:1320.1
Caspase-8 activates BID by cleavage
event
IEV:0000942
Hydrolysis of Bid by caspase8 in cytosol
IMR:0001203
IMR:0100289
REACT:1610.2
Granzyme-B activates BID by cleavage
event
IEV:0000943
Hydrolysis of Bid by granzyme B in cytosol
IMR:0001212
IMR:0100289
PubMed:11099414
REACT:1158.1
event
IEV:0000944
Myristoylation of Bid by NMT1 in cytosol
event
IEV:0000945
Myristoylation in cytosol
event
IEV:0000946
Isoprenylation in unidentified cellular location
event
IEV:0000947
Myristoylation in unidentified cellular location
GO:0001844
IMR:0100289
REACT:1370.3
event
IEV:0000948
Translocation of Bid from the cytosol to the mitochondria membrane
IMR:0100261
IMR:0100289
REACT:1062.2
event
IEV:0000949
Dissociation of Bid and Bcl-2 in mitochondria membrane
event
IEV:0000950
Dissociation in mitochondria membrane
GO:0008633
REACT:1194.2
Activation of NOXA and translocation to mitochondria
event
IEV:0000951
NOXA activation signaling
IMR:0001210
IMR:0100659
REACT:2201.3
Transactivation of NOXA by p53
event
IEV:0000952
Transcription of NOXA by p53 in nucleus
IMR:0000839
IMR:0001210
REACT:1872.3
Transactivation of NOXA by E2F1
event
IEV:0000953
Transcription of NOXA by E2F-1 in nucleus
GO:0001844
IMR:0001210
REACT:1585.3
event
IEV:0000954
Translocation of NOXA from the cytosol to the mitochondria membrane
GO:0008633
REACT:121.2
Activation of NOXA and translocation to mitochondria
event
IEV:0000955
PUMA activation signaling
IMR:0000839
IMR:0001211
REACT:284.3
Transactivation of PUMA by E2F1
event
IEV:0000956
Transcription of PUMA by E2F-1 in nucleus
IMR:0001211
IMR:0100659
REACT:1555.3
Transactivation of PUMA by p53
event
IEV:0000957
Transcription of PUMA by p53 in nucleus
GO:0001844
IMR:0001211
REACT:104.3
Translocation of PUMA protein to mitochondria
event
IEV:0000958
Translocation of PUMA from cytosol to the mitochondria membrane
GO:0008633
REACT:1650.2
Activation of BIM and translocation to mitochondria
event
IEV:0000959
Bim activation signaling
IMR:0000683
IMR:0001213
REACT:1888.3
event
IEV:0000960
Phosphorylation of DLC1 by MAPK8 in cytosol
IMR:0000191
IMR:0000200
IMR:0100291
PubMed:10198631
event
IEV:0000961
Dissociation of Bim and dynein:myosin V in cytosol
GO:0001844
IMR:0100291
REACT:750.3
Translocation of BIM to mitochondria
event
IEV:0000962
Translocation of Bim from the cytosol to the mitochondria membrane
GO:0008633
REACT:2100.2
Activation of BMF and translocation to mitochondria
event
IEV:0000963
Bmf activation signaling
IMR:0000683
IMR:0001209
REACT:1981.3
event
IEV:0000964
Phosphorylation of DLC2 by MAPK8 in cytosol
IMR:0000191
IMR:0000200
IMR:0001208
event
IEV:0000965
Dissociation of Bmf and dynein:myosin V in cytosol
GO:0001844
IMR:0001208
REACT:600.3
Translocation of BMF to mitochondria
event
IEV:0000966
Translocation of Bmf from the cytosol to the mitochondria membrane
event
IEV:0000967
Inactivation in mitochondria membrane
IMR:0100261
IMR:0100288
REACT:330.1
event
IEV:0000968
Inactivation of Bcl-2 by Bad in mitochondria membrane
IMR:0100288
IMR:0100293
REACT:21278.1
event
IEV:0000969
Inactivation of Bcl-xL by Bad in mitochondria membrane
IMR:0100261
IMR:0100289
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
REACT:784.2
event
IEV:0000970
Inactivation of Bid by Bcl-2 in mitochondria membrane
IMR:0100261
IMR:0100291
REACT:330.1
event
IEV:0000971
Inactivation of Bcl-2 by Bim in mitochondria membrane
IMR:0100289
IMR:0100293
REACT:21278.1
event
IEV:0000972
Inactivation of Bcl-xL by Bid in mitochondria membrane
IMR:0100291
IMR:0100293
REACT:21278.1
event
IEV:0000973
Inactivation of Bcl-xL by Bim in mitochondria membrane
IMR:0001210
IMR:0100261
REACT:330.1
event
IEV:0000974
Inactivation of Bcl-2 by NOXA in mitochondria membrane
IMR:0001211
IMR:0100261
REACT:330.1
event
IEV:0000975
Inactivation of Bcl-2 by PUMA in mitochondria membrane
IMR:0001211
IMR:0100293
REACT:21278.1
event
IEV:0000976
Inactivation of Bcl-xL by PUMA in mitochondria membrane
IMR:0100706
REACT:21278.1
REACT:330.1
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
event
IEV:0000977
Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane
GO:0008633
IMR:0000453
IMR:0100289
PubMed:10950869
REACT:1506.2
tBID activates BAX protein
event
IEV:0000978
Activation of Bax by Bid in cytosol
event
IEV:0000979
Activation in mitochondria membrane
GO:0008633
REACT:707.3
Activation and oligomerization of BAK protein
event
IEV:0000980
Bak activation signaling
GO:0008633
IMR:0000452
IMR:0100289
REACT:1424.3
tBID activates BAK protein
event
IEV:0000981
Activation of Bak by Bid in mitochondria membrane
IMR:0000452
REACT:507.2
Oligomerization of BAK at the mitochondrial membrane
event
IEV:0000982
Oligomerization of Bak
event
IEV:0000983
Permeabilization of mitochondria
true
IMR:0001206
IMR:0001207
REACT:1322.1
Release of apoptotic factors from the mitochondria
event
IEV:0000984
Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol
event
IEV:0000985
Translocation from mitochondria to cytosol
IMR:0001207
REACT:1101.3
Release of SMAC from mitochondria
event
IEV:0000986
Permeabilization of mitochondria and Translocation of SMAC from mitochondria to cytosol
Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c.
GO:0008635
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
REACT:831.1
Cytochrome c-mediated apoptotic response
Effector caspase3 / 7 activation signaling (through Cyt c)
event
IEV:0000987
Cytochrome c mediated signaling
Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c.
GO:0008635
REACT:666.1
SMAC-mediated apoptotic response
event
IEV:0000988
SMAC mediated signaling
REACT:89.2
Formation of apoptosome
event
IEV:0000989
Apoptosome formation in cytosol
IMR:0001204
IMR:0001206
IMR:0100299
REACT:39.3
Cytochrome C:Apaf-1 binds Procaspase-9
event
IEV:0000990
Binding of Cyt c:Apaf1 and procaspase9 in cytosol
IMR:0100299
REACT:2116.3
Cleavage of Procaspase-9 to Caspase-9
event
IEV:0000991
Hydrolysis of Procaspase9 to Caspase9 in cytosol
IMR:0100296
IMR:0100297
IMR:0100298
IMR:0100299
REACT:607.3
Activation of caspases through apoptosome-mediated cleavage
event
IEV:0000992
Hydrolysis of Caspase3/6/7 by Caspase9 in cytosol
IMR:0100298
IMR:0100299
REACT:2165.3
Cleavage of Procaspase-7 by the apoptosome
event
IEV:0000993
Hydrolysis of Procaspase7 to Caspase7 by Caspase9 in cytosol
IMR:0100296
IMR:0100299
REACT:1460.5
Cleavage of Procaspase-3 by the apoptosome
event
IEV:0000994
Hydrolysis of Procaspase3 to Caspase3 by Caspase9 in cytosol
IMR:0000454
IMR:0001207
REACT:2190.2
SMAC binds to IAPs
event
IEV:0000995
Binding of SMAC and IAP in cytosol
IMR:0001207
IMR:0100296
IMR:0100331
REACT:1300.3
SMAC binds XIAP:Caspase-3
event
IEV:0000996
Dissociation of Caspase3 and SMAC:XIAP in cytosol
IMR:0000305
IMR:0000454
IMR:0001207
REACT:1767.2
SMAC-mediated dissociation of IAP:caspase complexes
event
IEV:0000997
Dissociation of Caspase and SMAC:IAP in cytosol
IMR:0001207
IMR:0100296
IMR:0100331
REACT:1090.2
SMAC binds XIAP:Caspase-3
event
IEV:0000998
Binding of SMAC and XIAP:Caspase3 in cytosol
IMR:0001207
IMR:0100298
IMR:0100331
REACT:2091.2
SMAC binds XIAP:Caspase-7
event
IEV:0000999
Binding of SMAC and XIAP:Caspase7 in cytosol
IMR:0001207
IMR:0100299
IMR:0100331
REACT:1312.2
SMAC binds XIAP:Caspase-9
event
IEV:0001000
Binding of SMAC and XIAP:Caspase9 in cytosol
IMR:0001207
IMR:0100298
IMR:0100331
REACT:2102.3
Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7
event
IEV:0001001
Dissociation of Caspase7 and SMAC:XIAP in cytosol
IMR:0001207
IMR:0100299
IMR:0100331
REACT:1035.3
Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9
event
IEV:0001002
Dissociation of Caspase9 and SMAC:XIAP in cytosol
GO:0006919
event
IEV:0001003
Caspase9 activation signaling
GO:0006919
GO:0008633
event
IEV:0001004
Caspase10 activation signaling
IMR:0100299
Caspase9 homodimer formation
event
IEV:0001005
Homodimerization of Caspase9 in cytosol
GO:0006919
Activation of Effector Caspases
event
IEV:0001006
Caspase3/6/7 activation signaling (through mitochondria)
IMR:0100296
IMR:0100297
IMR:0100298
event
IEV:0001007
Caspase3/6/7 homodimer formation in cytosol
GO:0006919
GO:0008633
REACT:1503.2
Activation of Pro-Caspase 8
event
IEV:0001008
Caspase8 activation signaling
GO:0006919
IMR:0100301
Activation of Pro-Caspase10
Cleavage of pro-caspase10
event
IEV:0001009
Hydrolysis of pro-caspase10 in cytosol
IMR:0100301
Caspase10 homodimer formation
Formation of Caspase10 dimer
event
IEV:0001010
Homodimerization of Caspase10 in cytosol
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
event
IEV:0001011
AIF mediated signaling
UniProt:O95831
event
IEV:0001012
Nuclear import of AIF
GO:0006919
Activation of Effector Caspases
event
IEV:0001013
Caspase3/6/7 activation signaling (not through mitochondria)
IMR:0100296
IMR:0100297
IMR:0100298
IMR:0100300
IMR:0100301
event
IEV:0001014
Hydrolysis of Procaspase3/6/7 by caspase8/10 in cytosol
IMR:0100296
IMR:0100298
UniProt:O00273
event
IEV:0001015
Hydrolysis of ICAD by Caspase3/7 in cytosol
UniProt:O76075
event
IEV:0001016
Nuclear import of CAD
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
GO:0006309
REACT:1213.3
Apoptosis induced DNA fragmentation
event
IEV:0001017
DNA fragmentation during apoptosis
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
GO:0006309
event
IEV:0001018
Regulation of Caspase cascade (through mitochondria)
event
IEV:0001019
Negative regulation of Caspase cascade
event
IEV:0001020
Positive regulation of Caspase cascade
event
IEV:0001021
Regulation of Caspase cascade (not through mitochondria)
event
IEV:0001022
Negative regulation of Caspase cascade (not through mitochondria)
event
IEV:0001023
Positive regulation of Caspase cascade (not through mitochondria)
REACT:14379.1
UniProt:O00273
UniProt:O76075
event
IEV:0001024
Binding of CAD and ICAD in cytosol
IMR:0000454
IMR:0100296
IMR:0100298
IMR:0100299
event
IEV:0001025
Binding of Caspase3/7/9 and IAP in cytosol
event
IEV:0001026
Hydrolysis in nucleus
UniProt:O95831
event
IEV:0001027
DNA fragmentation by AIF in inner space of nucleus
UniProt:O76075
event
IEV:0001028
DNA fragmentation by CAD in inner space of nucleus
GO:0030972
IMR:0100296
IMR:0100297
IMR:0100298
REACT:13541.1
cleavage of cytosolic proteins during apoptosis
event
IEV:0001029
Hydrolysis of cytosolic protein by caspase3/6/7 in cytosol
event
IEV:0001030
Apoptotic factor inactivation signaling
event
IEV:0001031
Cytosolic cation ion concentration decline
event
IEV:0001032
Dissociation outside the ER membrane
event
IEV:0001033
Dissociation in mitochondria
event
IEV:0001034
Dissociation in ER
event
IEV:0001035
Binding in ER
event
IEV:0001036
Binding in mitochondria
event
IEV:0001037
Binding outside the ER membrane
event
IEV:0001038
Dissociation outside the mitochondria membrane
event
IEV:0001039
Binding in inner space of mitochondria
event
IEV:0001040
Binding in inner space of ER
event
IEV:0001041
Binding in inner space of nucleus
event
IEV:0001042
Dissociation in nucleus
event
IEV:0001043
Dissociation in ER membrane
event
IEV:0001044
Dissociation in inner space of ER
event
IEV:0001045
Dissociation in inner space of mitochondria
event
IEV:0001046
Dissociation in inner space of nucleus
event
IEV:0001047
Dissociation in nuclear membrane
event
IEV:0001048
Dissociation outside the nuclear membrane
event
IEV:0001049
Dephosphorylation in nucleus
event
IEV:0001050
Dephosphorylation in inner space of nucleus
event
IEV:0001051
Hydrolysis in inner space of nucleus
event
IEV:0001052
Isomerization in cytosol
event
IEV:0001053
Isomerization in unidentified cellular location
event
IEV:0001054
SUMOylation in unidentified cellular location
event
IEV:0001055
SUMOylation in cytosol
IMR:0100614
REACT:2142.4
event
IEV:0001056
Proteasome degradation of cyclin D in cytosol
event
IEV:0001057
Lyase process in unidentified cellular location
event
IEV:0001058
Oxidation/Reduction in unidentified cellular location
event
IEV:0001059
Oxidation/Reduction in cytosol
event
IEV:0001060
Farnesylation in unidentified cellular location
event
IEV:0001061
Geranylgeranylation in unidentified cellular location
event
IEV:0001062
Geranylgeranylation in cytosol
event
IEV:0001063
Palmitoylation in cytosol
event
IEV:0001064
Palmitoylation in unidentified cellular location
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
event
IEV:0001065
Interaction in cytosol
true
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
XX:<new dbxref>
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
event
IEV:0001066
Interaction in unidentified cellular location
true
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
XX:<new dbxref>
EC:4.1.1
event
IEV:0001067
Decarboxylation
event
IEV:0001068
Decarboxylation in the cytosol
event
IEV:0001069
Decarboxylation in the unidentified cellular location
Progression from G1 phase to S phase of the mitotic cell cycle.
IEV:0000367
GO:0000082
KEGG:hsa04110
G1-S-phase transition process [Plant]
event
IEV:0001070
G1-S-phase transition
Progression from G1 phase to S phase of the mitotic cell cycle.
GO:0000082
IMR:0100600
IMR:0100602
IMR:0100614
REACT:2081.2
event
IEV:0001071
Binding of Cdk4/6 and cyclin D in cytosol
IMR:0100600
IMR:0100602
IMR:0100614
REACT:713.3
event
IEV:0001072
Nuclear import of Cdk4/6_p:cyclin D
IMR:0000461
IMR:0100600
IMR:0100602
REACT:1882.4
event
IEV:0001074
Phosphorylation of RB by Cdk4/6 in inner space of nucleus
IMR:0000845
IMR:0000848
event
IEV:0001075
Binding of E2F and DP-1 in inner space of nucleus
IMR:0000848
event
IEV:0001076
Transcription by E2F in nucleus
IMR:0000461
IMR:0000839
event
IEV:0001077
Dissociation of E2F-1 and RB_p in inner space of nucleus
IMR:0100598
IMR:0100618
REACT:1683.3
event
IEV:0001078
Binding of Cdk2 and cyclin E in cytosol
IMR:0100598
IMR:0100618
REACT:425.2
event
IEV:0001079
Nuclear import of Cdk2_p:cyclin E
IMR:0100383
IMR:0100659
Transactivation of p21 by p53
event
IEV:0001080
Gene expression of p21 by p53
IMR:0000461
IMR:0100598
REACT:8993.1
event
IEV:0001081
Phosphorylation of RB by Cdk2 in inner space of nucleus
event
IEV:0001082
Phosphorylation in inner space of nucleus
A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle.
GO:0033261
regulation of progression through S phase
event
IEV:0001083
Regulation of S phase
A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle.
GO:0033261
The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions.
GO:0008054
event
IEV:0001084
Cyclin D degradation signaling
The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions.
GO:0008054
IMR:0100618
REACT:926.3
event
IEV:0001085
Proteasome degradation of cyclin E in cytosol
IMR:0100618
REACT:926.3
event
IEV:0001086
Ubiquitination of Cyclin E in cytosol
IMR:0000447
IMR:0100600
IMR:0100602
REACT:7947.1
event
IEV:0001087
Binding of INK4 family and Cdk4/6 in cytosol
Interacts strongly with CDK4 and CDK6. Inhibits their ability to interact with cyclins D. Could act as a negative regulator of the proliferation of normal cells.
IMR:0100600
IMR:0100602
IMR:0701007
event
IEV:0001088
Binding of p16 and Cdk4/6 in cytosol
Interacts strongly with CDK4 and CDK6. Inhibits their ability to interact with cyclins D. Could act as a negative regulator of the proliferation of normal cells.
UniProt:P42771
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
IMR:0100600
IMR:0100602
IMR:0701008
event
IEV:0001089
Binding of p15 and Cdk4/6 in cytosol
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
UniProt:P42772
Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import.
IMR:0100384
IMR:0100598
REACT:334.3
event
IEV:0001090
Binding of p27 and Cdk2 in inner space of nucleus
Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import.
UniProt:P46527
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. May bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
IMR:0100383
IMR:0100598
REACT:334.3
event
IEV:0001091
Binding of p21 and Cdk2 in inner space of nucleus
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. May bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
UniProt:P38936
Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
IMR:0000559
UniProt:P12004
event
IEV:0001092
Binding of GADD45 and PCNA in cytosol
Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
UniProt:P24522
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
IMR:0100600
IMR:0100602
IMR:0701009
event
IEV:0001093
Binding of p18 and Cdk4/6 in cytosol
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
UniProt:P42773
Interacts strongly with CDK4 and CDK6.
IMR:0100600
IMR:0100602
IMR:0701013
event
IEV:0001094
Binding of p19 and Cdk4/6 in cytosol
Interacts strongly with CDK4 and CDK6.
UniProt:P55273
Progression through S phase, the part of the cell cycle during which DNA synthesis takes place.
GO:0051320
KEGG:hsa04110
MeSH:D016196
event
IEV:0001095
S phase
Progression through S phase, the part of the cell cycle during which DNA synthesis takes place.
GO:0051320
event
IEV:0001096
Negative regulation of S phase
event
IEV:0001097
Positive regulation of S phase
Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity. It also dephosphorylates CDK2 in complex with cyclin E, in vitro.
IMR:0100598
IMR:0100632
REACT:592.4
event
IEV:0001098
Dephosphorylation Cdk2 by Cdc25A in cytosol
Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity. It also dephosphorylates CDK2 in complex with cyclin E, in vitro.
UniProt:P30304
IMR:0100603
IMR:0100625
event
IEV:0001099
Binding of Cdk7 and Cyclin H in cytosol
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
IMR:0100598
IMR:0100603
event
IEV:0001100
Thr160
Phosphorylation of Cdk2 by Cdk7 in cytosol
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
UniProt:P50613
IMR:0100598
IMR:0100607
REACT:8996.1
event
IEV:0001101
Binding of Cdk2 and Cyclin A in cytosol
IMR:0000839
REACT:22145.1
event
IEV:0001102
Transcription by E2F-1 in nucleus
event
IEV:0001103
p53 signaling pathway
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand ( PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired ( DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
MeSH:D004249
event
IEV:0001104
DNA damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand ( PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired ( DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
MeSH:D004249
UniProt:Q13315
event
IEV:0001105
Activation of ATM by damaged DNA in cytosol
Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
GO:0051318
MeSH:D016193
event
IEV:0001106
G1 phase
Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
GO:0051318
event
IEV:0001107
p53 signaling pathway (through GADD45)
IMR:0100660
event
IEV:0001108
Negative feedback regulation of p53 signaling pathway by Mdm2
IMR:0100659
PubMed:10721693
PubMed:15021897
event
IEV:0001109
Proteasome degradation of p53 in cytosol
IMR:0100659
event
IEV:0001110
Gene expression by p53
IMR:0000559
IMR:0100659
event
IEV:0001111
Gene expression of GADD45 by p53
IMR:0000456
IMR:0100659
event
IEV:0001112
Gene expression of 14-3-3 by p53
IMR:0100659
IMR:0100660
PubMed:12860999
event
IEV:0001113
Gene expression of Mdm2 by p53
event
IEV:0001114
p53 signaling pathway (through apoptotic factor)
IMR:0000453
IMR:0100659
event
IEV:0001115
Gene expression of BAX by p53
IMR:0000559
event
IEV:0001116
Nuclear export of mRNA (GADD45)
IMR:0000559
IMR:0100659
event
IEV:0001117
Transcription of GADD45 by p53 in nucleus
IMR:0000559
event
IEV:0001118
Translation of GADD45 in cytosol
IMR:0100660
PubMed:12860999
event
IEV:0001119
Nuclear export of mRNA (Mdm2)
IMR:0100659
IMR:0100660
PubMed:12860999
event
IEV:0001120
Transcription of Mdm2 by p53 in nucleus
IMR:0100660
PubMed:12860999
event
IEV:0001121
Translation of Mdm2 in cytosol
event
IEV:0001122
Regulation of p53 degradation signaling
event
IEV:0001123
Negative regulation of p53 degradation signaling
event
IEV:0001124
Positive regulation of p53 degradation signaling
IMR:0100383
event
IEV:0001125
Nuclear export of mRNA (p21)
IMR:0100383
IMR:0100659
event
IEV:0001126
Transcription of p21 by p53 in nucleus
IMR:0100383
event
IEV:0001127
Translation of p21 in cytosol
IMR:0000453
event
IEV:0001128
Nuclear export of mRNA (BAX)
IMR:0000453
IMR:0100659
event
IEV:0001129
Transcription of BAX by p53 in nucleus
IMR:0000453
event
IEV:0001130
Translation of BAX in cytosol
IMR:0100597
IMR:0100610
REACT:6216.2
Binding of Cdk1 and CyclinB in cytosol
event
IEV:0001131
Binding of Cdc2 and CyclinB in cytosol
IMR:0100597
IMR:0100607
REACT:6308.2
Binding of Cdk1 and CyclinA in cytosol
event
IEV:0001132
Binding of Cdc2 and CyclinA in cytosol
IMR:0100597
IMR:0100603
Phosphorylation of Cdk1 by Cdk7 in cytosol
event
IEV:0001133
UniProt:P50613, Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Phosphorylation of Cdc2 by Cdk7 in cytosol
Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
IMR:0100597
IMR:0100634
REACT:6257.1
event
IEV:0001134
Dephosphorylation Cdc2 by Cdc25C in cytosol
Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
XX:<new dbxref>
May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on Tyr-15 and phosphorylation of monomeric CDC2 does not occur.
CATALYTIC ACTIVITY: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
IMR:0100597
IMR:0100640
REACT:6178.2
REACT:6327.2
Phosphorylation of Cdk1 by Wee1 in cytosol
event
IEV:0001135
Phosphorylation of Cdc2 by Wee1 in cytosol
May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on Tyr-15 and phosphorylation of monomeric CDC2 does not occur.
CATALYTIC ACTIVITY: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
UniProt:P30291
Any process that decreases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010972
event
IEV:0001136
Negative regulation of G2-M-phase transition
Any process that decreases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010972
Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010389
event
IEV:0001137
Regulation of G2-M-phase transition
Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010389
Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010971
event
IEV:0001138
Positive regulation of G2-M-phase transition
Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
GO:0010971
TGF beta super family signaling pathway (through p15)
event
IEV:0001139
TGF beta super family signaling (through p15)
TGF beta super family signaling pathway (through p21)
event
IEV:0001140
TGF beta super family signaling (through p21)
IMR:0100384
event
IEV:0001141
Activation of p27 by Contact pressure in cytosol
IMR:0000370
event
IEV:0001142
Gene expression by Smad complex
IMR:0000370
IMR:0701008
event
IEV:0001143
Gene expression of p15 by Smad complex
IMR:0100659
event
IEV:0001144
Transcription by p53 in nucleus
IMR:0000370
event
IEV:0001145
Transcription by Smad complex in nucleus
IMR:0701008
event
IEV:0001146
Nuclear export of mRNA (p15)
IMR:0000370
IMR:0701008
event
IEV:0001147
Transcription of p15 by Smad complex in nucleus
IMR:0701008
event
IEV:0001148
Translation of p15 in cytosol
TGF beta super family signaling pathway (through p16)
event
IEV:0001149
TGF beta super family signaling (through p16)
TGF beta super family signaling pathway (through p27)
event
IEV:0001150
TGF beta super family signaling (through p27)
IMR:0100383
event
IEV:0001151
Activation of p21 by Contact pressure in cytosol
event
IEV:0001152
Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)
event
IEV:0001153
Negative regulation of G1-S-phase transition pathway by contact pressure (through p21)
IMR:0701007
event
IEV:0001154
Translation of p16 in cytosol
IMR:0000370
IMR:0701007
event
IEV:0001155
Gene expression of p16 by Smad complex
IMR:0701007
event
IEV:0001156
Nuclear export of mRNA (p16)
IMR:0000370
IMR:0701007
event
IEV:0001157
Transcription of p16 by Smad complex in nucleus
IMR:0000370
IMR:0100383
event
IEV:0001158
Gene expression of p21 by Smad complex
IMR:0000370
IMR:0100383
event
IEV:0001159
Transcription of p21 by Smad complex in nucleus
IMR:0100384
event
IEV:0001160
Translation of p27 in cytosol
IMR:0000370
IMR:0100384
event
IEV:0001161
Transcription of p27 by Smad complex in nucleus
IMR:0000370
IMR:0100384
event
IEV:0001162
Gene expression of p27 by Smad complex
IMR:0100384
event
IEV:0001163
Nuclear export of mRNA (p27)
IMR:0100712
PubMed:14985712
event
IEV:0001164
Hydrolysis of precursor Notch by convertase in Golgi
event
IEV:0001165
Hydrolysis in Golgi
IMR:0100712
PubMed:14985712
event
IEV:0001166
Translocation of Notch from the Golgi to plasma membrane
The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
GO:0006893
Golgi to plasma membrane transport
Golgi to plasma membrane vesicle-mediated transport
event
IEV:0001167
Translocation from Golgi to plasma membrane
The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
GO:0006893
IMR:0001920
IMR:0100712
PubMed:14985712
event
IEV:0001168
Binding of Notch and DSL ligand in extracellular
near the transmembrane domain
IMR:0001865
IMR:0100712
PubMed:14985712
event
IEV:0001169
Hydrolysis of Notch by ADAM in plasma membrane
near the transmembrane domain
XX:<new dbxref>
within the transmembrane domain
IMR:0000560
IMR:0100712
PubMed:14985712
event
IEV:0001170
Hydrolysis of Notch by Presenilin in plasma membrane
within the transmembrane domain
XX:<new dbxref>
IMR:0100712
PubMed:14985712
event
IEV:0001171
Nuclear import of Notch (NIC) from the plasma membrane
IMR:0100712
IMR:0100723
PubMed:14985712
event
IEV:0001172
Binding of Notch (NIC) and CSL in inner space of nucleus
IMR:0000424
IMR:0100712
PubMed:14985712
event
IEV:0001173
Binding of Notch (NIC) and coactivator in inner space of nucleus
GO:0007221
IMR:0000368
IMR:0100712
PubMed:14985712
event
IEV:0001174
Binding of Notch (NIC) and transcription factor in inner space of nucleus
IMR:0000427
IMR:0100723
PubMed:14985712
event
IEV:0001175
Dissociation of CSL and corepressor in inner space of nucleus
IGS:0000028
IMR:0100723
PubMed:14985712
event
IEV:0001176
Binding of CSL and responsive element in inner space of nucleus
IMR:0100712
IMR:0100723
PubMed:14985712
event
IEV:0001177
Transcription by CSL:Notch (NIC) in nucleus
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
GO:0008593
event
IEV:0001178
Regulation of Notch signaling pathway
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
GO:0008593
Any process that stops, prevents or reduces the rate, frequency or extent of the Notch signaling pathway.
GO:0045746
event
IEV:0001179
Negative regulation of Notch signaling pathway
Any process that stops, prevents or reduces the rate, frequency or extent of the Notch signaling pathway.
GO:0045746
Any process that activates or increases the rate, frequency or extent of the Notch signaling pathway.
GO:0045747
event
IEV:0001180
Positive regulation of Notch signaling pathway
Any process that activates or increases the rate, frequency or extent of the Notch signaling pathway.
GO:0045747
IMR:0100712
IMR:0100718
PubMed:14985712
event
IEV:0001181
Binding of Notch and Delta in extracellular
IMR:0001910
IMR:0100714
PubMed:14985712
event
IEV:0001182
Binding of Notch1 and Jagged1 in extracellular
IMR:0001852
IMR:0100714
PubMed:14985712
event
IEV:0001183
Binding of Notch1 and Fringe in Golgi
event
IEV:0001184
Binding in Golgi
IMR:0001852
IMR:0100712
PubMed:14985712
event
IEV:0001185
Binding of Notch and Fringe
PubMed:14985712
event
IEV:0001186
Delta mediated Notch signaling pathway
PubMed:14985712
event
IEV:0001187
Jagged mediated Notch signaling pathway
event
IEV:0001188
Regulation of Delta mediated Notch signaling pathway
event
IEV:0001189
Negative regulation of Delta mediated Notch signaling pathway
event
IEV:0001190
Positive regulation of Delta mediated Notch signaling pathway
event
IEV:0001191
Regulation of Jagged mediated Notch signaling pathway
event
IEV:0001192
Negative regulation of Jagged mediated Notch signaling pathway
event
IEV:0001193
Positive regulation of Jagged mediated Notch signaling pathway
IMR:0001961
IMR:0100723
PubMed:14985712
event
IEV:0001194
Binding of Mint and CSL in inner space of nucleus
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
OBSOLETE: remap to 'Activation of Deltex' IEV:0003541.
PubMed:14985712
event
IEV:0001195
Activation of Deltex [Mammalian]
true
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
OBSOLETE: remap to 'Activation of Deltex' IEV:0003541.
UniProt:Q86Y01
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as an ubiquitin ligase protein in the Notch pathway.
OBSOLETE: remap to 'Activation of Deltex' IEV:0003541.
PubMed:14985712
event
IEV:0001196
Activation of Deltex [Drosophila]
true
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as an ubiquitin ligase protein in the Notch pathway.
OBSOLETE: remap to 'Activation of Deltex' IEV:0003541.
UniProt:Q23985
OBSOLETE: remap to 'Activation of Numb' IEV:0003542.
PubMed:14985712
event
IEV:0001197
Activation of Numb [Mammalian]
true
OBSOLETE: remap to 'Activation of Numb' IEV:0003542.
XX:<new dbxref>
Signal transduction by the BCR and coreceptor complexes is initiated by the recruitment and activation of tyrosine kinases. Upon antigen binding, membrane immunoglobulin and the Ig alpha-Ig beta heterodimer translocate to the glycolipid and cholesterol-rich membrane microdomains (lipid rafts) wherein fatty-acid-modified Src family kinases are constitutively present. Similarly, coengagement of the BCR and CD21 with multimeric C3d(g) bound to antigen promotes CD19-CD21-CD81 partitioning to the rafts, functioning to augment and potentiate signal transduction.
IMR:0000153
PubMed:15886112
BCR receptor complex and coreceptor complex formation
event
IEV:0001198
Complex formation of BCR complex and coreceptor in plasma membrane
Signal transduction by the BCR and coreceptor complexes is initiated by the recruitment and activation of tyrosine kinases. Upon antigen binding, membrane immunoglobulin and the Ig alpha-Ig beta heterodimer translocate to the glycolipid and cholesterol-rich membrane microdomains (lipid rafts) wherein fatty-acid-modified Src family kinases are constitutively present. Similarly, coengagement of the BCR and CD21 with multimeric C3d(g) bound to antigen promotes CD19-CD21-CD81 partitioning to the rafts, functioning to augment and potentiate signal transduction.
PubMed:15886112
The assembly and arrangement of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments.
GO:0031032
event
IEV:0001199
Actomyosin structure organization and biogenesis
The assembly and arrangement of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments.
GO:0031032
KEGG:hsa04510
event
IEV:0001200
Integrin signaling pathway (through PI3K, Vav and Rac)
CHEBI:50114
IMR:0000088
PubMed:11559590
PubMed:15385571
PubMed:17336390
event
IEV:0001201
Binding of Estrogen and Estrogen receptor in inner space of nucleus
CHEBI:50114
PubMed:15385571
event
IEV:0001202
Translocation of Estrogen from extracellular to cytosol
event
IEV:0001203
Translocation from extracellular to cytosol
GO:0016514
IMR:0000088
PubMed:11559590
event
IEV:0001204
Binding of Estrogen receptor and SWI/SNF complex in inner space of nucleus
CHEBI:50114
PubMed:15385571
event
IEV:0001205
Nuclear import of Estrogen
IMR:0000088
PubMed:15385571
PubMed:17336390
Estrogen receptor complex formation
event
IEV:0001206
Complex formation of Estrogen receptor in inner space of nucleus
IGS:0000028
IMR:0000088
PubMed:11559590
event
IEV:0001207
Binding of Estrogen receptor and responsive element in inner space of nucleus
IMR:0000088
IMR:0000368
PubMed:11559590
event
IEV:0001208
Binding of Estrogen receptor and transcription factor in inner space of nucleus
IMR:0000088
PubMed:11559590
event
IEV:0001209
Binding of Estrogen receptor and p160 coactivator in inner space of nucleus
IMR:0000088
IMR:0100615
PubMed:11559590
event
IEV:0001210
Binding of Estrogen receptor and cyclin D1 in inner space of nucleus
IMR:0000088
PubMed:11559590
UniProt:Q13330
event
IEV:0001211
Binding of Estrogen receptor and MTA-1 in inner space of nucleus
IMR:0000088
IMR:0000427
PubMed:11559590
event
IEV:0001212
Binding of Estrogen receptor and corepressor in inner space of nucleus
IMR:0000088
PubMed:11559590
UniProt:O75376
event
IEV:0001213
Binding of Estrogen receptor and NCOR1 in inner space of nucleus
IMR:0000088
PubMed:11559590
UniProt:Q9Y618
event
IEV:0001214
Binding of Estrogen receptor and NCOR2 in inner space of nucleus
IMR:0000088
PubMed:11136970
PubMed:11559590
PubMed:12040178
event
IEV:0001215
Transcription factor complex formation with Estrogen receptor in inner space of nucleus
IMR:0000368
IMR:0001404
PubMed:11559590
event
IEV:0001216
Binding of Transcription factor complex and CBP in inner space of nucleus
IMR:0000368
IMR:0001166
PubMed:11559590
event
IEV:0001217
Binding of Transcription factor complex and HDAC in inner space of nucleus
IMR:0000368
PubMed:11559590
UniProt:Q92831
event
IEV:0001218
Binding of Transcription factor complex and pCAF in inner space of nucleus
IMR:0000368
IMR:0001405
PubMed:11559590
event
IEV:0001219
Binding of Transcription factor complex and p300 in inner space of nucleus
IMR:0000368
IMR:0001176
PubMed:11559590
event
IEV:0001220
Binding of Transcription factor complex and HAT in inner space of nucleus
IMR:0000088
PubMed:11559590
event
IEV:0001221
Transcription by Estrogen receptor in nucleus
event
IEV:0001222
Src activation signaling
IMR:0100575
IMR:0700224
PubMed:12415108
event
IEV:0001223
Binding of Src and Estrogen receptor beta:MNAR
IMR:0000088
PubMed:12415108
UniProt:Q8IZL8
event
IEV:0001224
Binding of Estrogen receptor and MNAR
IMR:0700220
PubMed:12415108
UniProt:Q8IZL8
event
IEV:0001225
Binding of Estrogen receptor alpha and MNAR
IMR:0700224
PubMed:12415108
UniProt:Q8IZL8
event
IEV:0001226
Binding of Estrogen receptor beta and MNAR
event
IEV:0001227
PI3K activation signaling
IMR:0000266
IMR:0700220
PubMed:11029009
event
IEV:0001228
Binding of Estrogen receptor alpha and p85 in cytosol
CHEBI:50114
IMR:0700220
PubMed:11559590
event
IEV:0001229
Binding of Estrogen and Estrogen receptor alpha in inner space of nucleus
CHEBI:50114
IMR:0700224
PubMed:11559590
event
IEV:0001230
Binding of Estrogen and Estrogen receptor beta in inner space of nucleus
Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor.
GO:0030518
steroid hormone receptor signaling pathway
event
IEV:0001231
Steroid receptor signaling pathway
Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor.
GO:0030518
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
GO:0030521
event
IEV:0001232
Androgen receptor signaling pathway
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
GO:0030521
event
IEV:0001233
TPO signaling pathway (JAK2, STAT3)
event
IEV:0001234
TPO signaling pathway (through Sos, Ras and Erk cascade)
event
IEV:0001235
TPO signaling pathway (through PI3K, PLCgamma and PKC)
IMR:0000083
IMR:0100119
PubMed:12536131
PubMed:14556714
event
IEV:0001236
Binding of Glutamate and NMDA receptor
IMR:0100119
PubMed:14556714
event
IEV:0001237
Binding of Glutamate and AMPA receptor
KEGG:C01330
PubMed:14556714
event
IEV:0001238
Translocation of sodium ion from extracellular to cytosol (through AMPA receptor)
event
IEV:0001239
Changes in polarization state of the membrane
PubMed:14556714
event
IEV:0001240
Depolarization state of the postsynaptic cell
event
IEV:0001241
Changes in polarization state of postsynaptic cell membrane
IMR:0000083
KEGG:C00305
PubMed:14556714
event
IEV:0001242
Dissociation of magnesium ion and NMDA receptor in plasma membrane
IMR:0100031
KEGG:C01330
PubMed:14556714
event
IEV:0001243
Translocation of calcium and sodium ion from extracellular to cytosol (through NMDA receptor)
KEGG:hsa04720
PubMed:14556714
event
IEV:0001244
Long-Term Potentiation
IMR:0000457
IMR:0100031
PubMed:14556714
event
IEV:0001245
Binding of calcium ion and calmodulin in cytosol
Any process that increases the concentration of calcium ions in the cytosol.
GO:0007204
elevation of calcium ion concentration in cytosol
elevation of cytosolic calcium ion concentration
event
IEV:0001246
Cytosolic calcium ion concentration elevation
Any process that increases the concentration of calcium ions in the cytosol.
GO:0007204
elevation of calcium ion concentration in cytosol
GO:0007204
elevation of cytosolic calcium ion concentration
GO:0007204
PubMed:14556714
event
IEV:0001247
Cytosolic calcium ion concentration elevation (through Glutamate receptor)
IMR:0000457
IMR:0100031
IMR:0100548
PubMed:14556714
event
IEV:0001248
Binding of calcium calmodulin and CaMKII in cytosol
event
IEV:0001249
Cytosolic cation ion concentration decline (through cGMP activated cation ion channel)
IMR:0100031
event
IEV:0001250
Translocation of calcium ion from the cytosol to the extracellular
event
IEV:0001251
Translocation from cytosol to extracellular
IMR:0000682
IMR:0002372
event
IEV:0001252
Binding of TCR-CD3 complex and non-receptor tyrosine kinase in cytosol
IMR:0000682
IMR:0100287
PubMed:12040176
event
IEV:0001253
Phosphorylation of CD3 zeta by non-receptor tyrosine kinase in cytosol
The series of successive proteolytic cleavage events that take place after a Notch receptor binds a ligand, and which lead to the release of the Notch Intracellular Domain (NICD), which is the active form of the receptor.
GO:0007220
PubMed:14985712
event
IEV:0001254
Notch receptor processing
The series of successive proteolytic cleavage events that take place after a Notch receptor binds a ligand, and which lead to the release of the Notch Intracellular Domain (NICD), which is the active form of the receptor.
GO:0007220
The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
GO:0001881
event
IEV:0001255
Receptor recycling
The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
GO:0001881
true
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
GO:0048008
PDGF signaling pathway
PDGFR signaling pathway
platelet-derived growth factor receptor signaling pathway
event
IEV:0001257
PDGF receptor signaling pathway
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
GO:0048008
PDGF signaling pathway
GO:0048008
PDGFR signaling pathway
GO:0048008
platelet-derived growth factor receptor signaling pathway
GO:0048008
A series of molecular signals within the cell that are mediated by a member of the Ras family of proteins switching to a GTP-bound active state.
GO:0007265
Ras mediated signal transduction
Ras protein signal transduction
event
IEV:0001258
Ras mediated signaling
A series of molecular signals within the cell that are mediated by a member of the Ras family of proteins switching to a GTP-bound active state.
GO:0007265
Ras mediated signal transduction
GO:0007265
Ras protein signal transduction
GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
GO:0016601
Rac mediated signal transduction
Rac protein signal transduction
event
IEV:0001259
Rac mediated signaling
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
GO:0016601
Rac mediated signal transduction
GO:0016601
Rac protein signal transduction
GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
GO:0007266
Rho mediated signal transduction
Rho protein signal transduction
event
IEV:0001260
Rho mediated signaling
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
GO:0007266
Rho mediated signal transduction
GO:0007266
Rho protein signal transduction
GO:0007266
KEGG:hsa04510
KEGG:hsa04810
KEGG:mmu04810
KEGG:rno04810
event
IEV:0001261
Rho-p160-myosin phosphatase signaling
KEGG:hsa04510
event
IEV:0001262
Rho-PI5K signaling
A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.
GO:0032484
Ral protein signal transduction
event
IEV:0001263
Ral mediated signaling
A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.
GO:0032484
event
IEV:0001264
I-kappaB degradation signaling
true
true
Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043122
regulation of I-kappaB kinase/NF-kappaB cascade
event
IEV:0001267
Regulation of IKK-NF-kappaB signaling
Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043122
Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043124
downregulation of I-kappaB kinase/NF-kappaB cascade
negative regulation of I-kappaB kinase/NF-kappaB cascade
event
IEV:0001268
Negative regulation of IKK-NF-kappaB signaling
Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043124
Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043123
positive regulation of I-kappaB kinase/NF-kappaB cascade
upregulation of I-kappaB kinase/NF-kappaB cascade
event
IEV:0001269
Positive regulation of IKK-NF-kappaB signaling
Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
GO:0043123
GO:0042501
IMR:0000224
IMR:0000374
event
IEV:0001270
Phosphorylation of STAT by MAPK in cytosol
IMR:0000153
PubMed:15886112
BCR complex formation
event
IEV:0001271
Complex formation of BCR in plasma membrane
The B cell coreceptor complex, which is defined by its ability to bind and respond to C3d(g)-bound antigen, is composed of CD19, CD21 and the widely expressed CD81 and Leu13 proteins.
PubMed:15886112
B cell coreceptor complex formation
event
IEV:0001272
Complex formation of B cell coreceptor in plasma membrane
The B cell coreceptor complex, which is defined by its ability to bind and respond to C3d(g)-bound antigen, is composed of CD19, CD21 and the widely expressed CD81 and Leu13 proteins.
PubMed:15886112
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050855
Regulation of B cell receptor signaling pathway
event
IEV:0001273
Regulation of B cell receptor signaling
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050855
Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050859
Negative regulation of B cell receptor signaling pathway
event
IEV:0001274
Negative regulation of B cell receptor signaling
Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050859
Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050861
Positive regulation of B cell receptor signaling pathway
event
IEV:0001275
Positive regulation of B cell receptor signaling
Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
GO:0050861
IMR:0000275
PubMed:14632637
event
IEV:0001276
Negative regulation of B cell receptor signaling (through CD72 and SHP-1)
IMR:0000154
IMR:0000155
PubMed:14632637
IgM and Ig alpha:beta complex formation
event
IEV:0001277
Complex formation of IgM and Ig alpha:beta in plasma membrane
IMR:0000153
IMR:0000465
PubMed:14632637
event
IEV:0001278
Binding of antigen and BCR complex in extracellular
The immunoglobulin (Ig) and Ig cytoplasmic tails are phosphorylated on the immunoreceptor tyrosine-based activation motif (ITAM) tyrosines by Src-family tyrosine kinases (SFTKs) and/or Syk.
IMR:0000155
IMR:0000682
PubMed:14632637
event
IEV:0001279
Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase in cytosol
The immunoglobulin (Ig) and Ig cytoplasmic tails are phosphorylated on the immunoreceptor tyrosine-based activation motif (ITAM) tyrosines by Src-family tyrosine kinases (SFTKs) and/or Syk.
PubMed:14632637
IMR:0000155
IMR:0000211
PubMed:14632637
event
IEV:0001280
Phosphorylation of Ig alpha:beta by Lyn in cytosol
IMR:0000155
IMR:0000222
PubMed:14632637
event
IEV:0001281
Phosphorylation of Ig alpha:beta by Syk in cytosol
IMR:0000155
IMR:0000211
PubMed:14632637
event
IEV:0001282
Phosphorylation of Ig alpha:beta by Src family in cytosol
he B-cell linker protein (BLNK) binds to tyrosine 204 of Ig alpha.
IMR:0000222
IMR:0100541
PubMed:14632637
event
IEV:0001283
Binding of Ig alpha and Syk in cytosol
he B-cell linker protein (BLNK) binds to tyrosine 204 of Ig alpha.
PubMed:14632637
IMR:0000353
IMR:0100541
PubMed:14632637
event
IEV:0001284
Binding of Ig alpha and BLNK in cytosol
IMR:0000215
IMR:0000353
PubMed:14632637
event
IEV:0001285
Binding of BLNK and BtK in cytosol
IMR:0000285
IMR:0000353
PubMed:14632637
event
IEV:0001286
Binding of BLNK and PLC gamma in cytosol
IMR:0000284
IMR:0000949
event
IEV:0001287
Binding of tyrosine-phosphorylated protein and PLC in cytosol
IMR:0000284
IMR:0000682
event
IEV:0001288
Phosphorylation of PLC by non-receptor tyrosine kinase in cytosol
IMR:0100027
IMR:0100484
PubMed:15343367
event
IEV:0001289
Binding of DAG and PKC theta and active conformational change of PKC theta in cytosol
IMR:0000215
IMR:0000285
PubMed:14632637
event
IEV:0001290
Phosphorylation of PLC gamma by Btk in cytosol
IMR:0000285
IMR:0000949
event
IEV:0001291
Binding of tyrosine-phosphorylated protein and PLC gamma in cytosol
IMR:0000155
IMR:0100352
PubMed:14632637
event
IEV:0001292
Phosphorylation of Ig alpha:beta by Fyn in cytosol
IMR:0000155
PubMed:14632637
UniProt:P51451
event
IEV:0001293
Phosphorylation of Ig alpha:beta by Blk in cytosol
PubMed:14632637
B cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
event
IEV:0001294
B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
PubMed:14632637
B cell receptor signaling pathway (through Ras and ERK cascade)
event
IEV:0001295
B cell receptor signaling (through Ras and ERK cascade)
PubMed:14632637
B cell receptor signaling pathway (through Vav and Rac)
event
IEV:0001296
B cell receptor signaling (through Vav and Rac)
IMR:0000340
IMR:0000353
PubMed:14632637
event
IEV:0001297
Binding of BLNK and Grb2 in cytosol
B cell receptor signaling pathway (through IKK-NF-kappaB cascade)
event
IEV:0001298
B cell receptor signaling (through IKK-NF-kappaB cascade)
IMR:0000353
IMR:0000434
PubMed:14632637
event
IEV:0001299
Binding of BLNK and Vav in cytosol
event
IEV:0001300
Rac activation signaling
event
IEV:0001301
Small GTPase activation signaling
event
IEV:0001302
Calcium ion dependent protein activation signaling
event
IEV:0001303
Calcineurin activation signaling
event
IEV:0001304
CaMKII activation signaling
IMR:0000278
IMR:0000457
IMR:0100031
event
IEV:0001305
Binding of calcium calmodulin and calcineurin in cytosol
IMR:0000278
IMR:0100031
event
IEV:0001306
Binding of calcium ion and calcineurin in cytosol
IMR:0000211
IMR:0000382
PubMed:14632637
NF-kappaB activation
event
IEV:0001307
Activation of NF-kappaB by Src family in cytosol
IMR:0000382
event
IEV:0001308
Transcription by NF-kappaB in nucleus
IMR:0000278
IMR:0000421
event
IEV:0001309
Dephosphorylation of NF-AT by calcineurin in cytosol
The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane.
GO:0051531
IMR:0000421
NFAT protein import into nucleus
NFAT protein nuclear translocation
NFAT protein nucleus import
NFAT protein transport from cytoplasm to nucleus
event
IEV:0001310
Nuclear import of NF-AT
The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane.
GO:0051531
IMR:0000278
event
IEV:0001311
Nuclear import of calcineurin
IMR:0000421
event
IEV:0001312
Transcription by NF-AT in nucleus
PubMed:12415108
event
IEV:0001313
Src activation signaling (through Estrogen receptor)
The process whereby a relatively unspecialized precursor cell acquires specialized features of B-cells, T-cells, or natural killer cells.
GO:0030098
event
IEV:0001314
Lymphocyte differentiation
The process whereby a relatively unspecialized precursor cell acquires specialized features of B-cells, T-cells, or natural killer cells.
GO:0030098
The rapid expansion of a lymphocyte population by cell division.
GO:0046651
event
IEV:0001315
Lymphocyte proliferation
The rapid expansion of a lymphocyte population by cell division.
GO:0046651
Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
GO:0051319
GO:D016195
event
IEV:0001316
G2 phase
Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
GO:0051319
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0007154
event
IEV:0001319
Cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0007154
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0016043
cell component organization and biogenesis
cell organisation
event
IEV:0001320
Cellular component organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0016043
cell component organization and biogenesis
GO:0016043
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0007028
cytoplasm organisation
event
IEV:0001321
Cytoplasm organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0007028
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0006996
organelle organisation
event
IEV:0001322
Organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0006996
The assembly and arrangement of cytoskeletal structures comprising actin filaments and their associated proteins.
GO:0030036
event
IEV:0001323
Actin cytoskeleton organization and biogenesis
The assembly and arrangement of cytoskeletal structures comprising actin filaments and their associated proteins.
GO:0030036
Control of the spatial distribution of actin filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
GO:0007015
event
IEV:0001324
Actin filament organization
Control of the spatial distribution of actin filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
GO:0007015
The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form.
GO:0000902
cellular morphogenesis
event
IEV:0001325
Cell morphogenesis
The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form.
GO:0000902
UniProt:O95831
event
IEV:0001326
Permeabilization of mitochondria and Translocation of AIF from mitochondria to cytosol
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
GO:0032501
Organismal physiological process
event
IEV:0001327
Multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
GO:0032501
Organismal physiological process
GO:0050874
The specific actions or reactions of an organism that recur with measured regularity.
GO:0007622
event
IEV:0001328
Rhythmic behavior
The specific actions or reactions of an organism that recur with measured regularity.
GO:0007622
Processes aimed at the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves.
GO:0048316
event
IEV:0001329
Seed development
Processes aimed at the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves.
GO:0048316
event
IEV:0001330
Physiological event
GO:0042592
homeostatic process
event
IEV:0001331
Homeostasis
A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a stimulus.
GO:0050896
event
IEV:0001332
Response to stimulus
A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a stimulus.
GO:0050896
A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a biotic stimulus.
GO:0009607
event
IEV:0001333
Response to biotic stimulus
A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a biotic stimulus.
GO:0009607
true
A change in state or activity of a cell or an organism as a result of the perception of an endogenous stimulus.
GO:0009719
event
IEV:0001335
Response to endogenous stimulus
A change in state or activity of a cell or an organism as a result of the perception of an endogenous stimulus.
GO:0009719
A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of an external stimulus.
GO:0009605
event
IEV:0001336
Response to external stimulus
A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of an external stimulus.
GO:0009605
A change in state or activity of an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) that occurs in response to stress, usually, but not necessarily exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0006950
event
IEV:0001337
Response to stress
A change in state or activity of an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) that occurs in response to stress, usually, but not necessarily exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0006950
The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts.
GO:0048460
event
IEV:0001338
Flower formation
The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts.
GO:0048460
IEV:0000395
Wood formation
event
IEV:0001339
Wood development
IEV:0000399
Bud formation
event
IEV:0001340
Bud development
A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of damage to the organism.
GO:0009611
event
IEV:0001341
Response to wounding
A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of damage to the organism.
GO:0009611
The series of events that restore integrity to a damaged tissue, following an injury.
GO:0042060
event
IEV:0001342
Wound healing
The series of events that restore integrity to a damaged tissue, following an injury.
GO:0042060
Combining with interleukin-2 to initiate a change in cell activity.
GO:0004911
GO:0005134
IMR:0000008
IMR:0000097
PubMed:10920190
event
IEV:0001343
Binding of IL-2 and IL-2 receptor and conformational change of receptors in plasma membrane
Combining with interleukin-2 to initiate a change in cell activity.
GO:0004911
Combining with interleukin-3 to initiate a change in cell activity.
GO:0004912
GO:0005135
IMR:0000012
IMR:0000109
event
IEV:0001344
Binding of IL3 and IL3 receptor and conformational change of receptors in plasma membrane
Combining with interleukin-3 to initiate a change in cell activity.
GO:0004912
Combining with interleukin-4 to initiate a change in cell activity.
GO:0004913
GO:0005136
IMR:0000107
IMR:0000585
event
IEV:0001345
Binding of IL4 and IL4 receptor and conformational change of receptors in plasma membrane
Combining with interleukin-4 to initiate a change in cell activity.
GO:0004913
true
Combining with interleukin-12 to initiate a change in cell activity.
GO:0005143
GO:0016517
IMR:0000590
IMR:0000602
PubMed:12805384
event
IEV:0001347
Binding of IL-12 and IL-12 receptor and conformational change of receptors in plasma membrane
Combining with interleukin-12 to initiate a change in cell activity.
GO:0016517
Combining with interleukin-10 to initiate a change in cell activity.
GO:0004920
GO:0005141
IMR:0000589
IMR:0000608
PubMed:12626585
event
IEV:0001348
Binding of IL-10 and IL-10 receptor and conformational change of receptors in plasma membrane
Combining with interleukin-10 to initiate a change in cell activity.
GO:0004920
PKC then phosphorylates and regulates the activity of many proteins, including EGFR; phosphorylation of a threonine residue (Thr654) in the juxtamembrane domain modulates EGF binding affinity and kinase activity of the EGFR.
IMR:0000081
IMR:0000245
PubMed:15567847
event
IEV:0001349
Phosphorylation of EGFR by PKC in cytosol
PKC then phosphorylates and regulates the activity of many proteins, including EGFR; phosphorylation of a threonine residue (Thr654) in the juxtamembrane domain modulates EGF binding affinity and kinase activity of the EGFR.
PubMed:15567847
Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
GO:0042058
regulation of EGF receptor signaling pathway
regulation of EGFR signaling pathway
regulation of epidermal growth factor receptor signaling pathway
event
IEV:0001350
Regulation of EGF signaling pathway
Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
GO:0042058
regulation of EGF receptor signaling pathway
GO:0042058
regulation of EGFR signaling pathway
GO:0042058
regulation of epidermal growth factor receptor signaling pathway
GO:0042058
Any process that stops, prevents or reduces the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity.
GO:0042059
event
IEV:0001351
Negative regulation of EGF receptor signaling pathway
Any process that stops, prevents or reduces the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity.
GO:0042059
Any process that activates or increases the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity.
GO:0045742
event
IEV:0001352
Positive regulation of EGF signaling pathway
Any process that activates or increases the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity.
GO:0045742
The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
GO:0006571
KEGG:map00400
tyrosine anabolism
tyrosine biosynthetic process
tyrosine formation
tyrosine synthesis
event
IEV:0001353
Tyrosine biosynthesis
The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
GO:0006571
cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes.
IMR:0001146
IMR:0100355
PubMed:9447975
event
IEV:0001354
Activation of c-Raf1 by PKC beta in cytosol
cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes.
PubMed:9447975
IMR:0000290
IMR:0001145
IMR:0001354
IMR:0100355
PubMed:12417593
event
IEV:0001355
Activation of Raf1 by Ras-GTP along with PKC alpha in cytosol
Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
event
IEV:0001356
Raf activation signaling (through RKIP)
Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
IMR:0000245
PubMed:12551925
UniProt:P30086
event
IEV:0001357
Phosphorylation of RKIP by PKC in cytosol
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1.
IMR:0100355
PubMed:12551925
UniProt:P30086
event
IEV:0001358
Dissociation of RKIP and Raf1 in cytosol
Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1.
PubMed:12551925
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
IMR:0100486
PubMed:12551925
UniProt:P30086
event
IEV:0001359
Phosphorylation of RKIP by cPKC in cytosol
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
IMR:0000247
PubMed:12551925
UniProt:P30086
event
IEV:0001360
Phosphorylation of RKIP by aPKC in cytosol
Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153).
PubMed:12551925
cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes.
IMR:0001145
IMR:0100355
PubMed:9447975
event
IEV:0001361
Activation of c-Raf1 by PKC alpha in cytosol
cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes.
PubMed:9447975
IMR:0000231
IMR:0000245
event
IEV:0001362
Activation of Raf by PKC in cytosol
At the level of Raf, the kinase that phosphorylates MEK-1, the activation cascade diverges; while conventional and novel PKCs (isotypes a and h) are potent activators of c-Raf1, atypical PKC-z cannot increase c-Raf1 activity,stimulating MEK by an independent mechanism.
IMR:0001150
IMR:0100355
PubMed:9447975
event
IEV:0001363
Activation of c-Raf1 by PKC eta in cytosol
At the level of Raf, the kinase that phosphorylates MEK-1, the activation cascade diverges; while conventional and novel PKCs (isotypes a and h) are potent activators of c-Raf1, atypical PKC-z cannot increase c-Raf1 activity,stimulating MEK by an independent mechanism.
PubMed:9447975
event
IEV:0001364
Raf activation signaling (through PKC)
IMR:0000732
IMR:0001352
PubMed:15343367
event
IEV:0001365
Binding of PLC gamma1 and PIP3 in cytosol
IMR:0000732
IMR:0001350
IMR:0100027
IMR:0100028
PubMed:15343367
event
IEV:0001366
Hydrolysis of PIP2 by PLC gamma1 to generate DAG and IP3 in cytosol
IMR:0000348
IMR:0000732
PubMed:12040176
PubMed:15343367
event
IEV:0001367
Binding of LAT_p and PLC gamma1 in cytosol
IMR:0000221
IMR:0000434
PubMed:15343367
event
IEV:0001368
Phosphorylation of Vav by ZAP-70 in cytosol
IMR:0000350
IMR:0000434
PubMed:12040176
PubMed:15343367
event
IEV:0001369
Binding of SLP-76 and Vav in cytosol
IMR:0000343
IMR:0000350
PubMed:12040176
PubMed:15343367
event
IEV:0001370
Binding of SLP-76 and Nck in cytosol
IMR:0000238
IMR:0000343
PubMed:12040176
PubMed:15343367
event
IEV:0001371
Binding of Nck and PAK in cytosol
T-cell lines expressing constitutively active PKC-theta, but not other constitutively active PKCs (alpha, delta, epsilon or zeta), were capable of activating an NF-kB reporter. Co-transfection experiments indicated that constitutively active PKC-theta upregulates the activity of IKKbeta, but not IKKalpha. Although a biochemical association between PKC-theta and IKKbeta could not be detected, the data suggest that PKC-theta directly or indirectly modulates IKKbeta kinase activity, thus regulating NF-kB.
IMR:0100459
IMR:0100484
PubMed:10733597
event
IEV:0001372
Activation of IKK beta by PKC theta in cytosol
T-cell lines expressing constitutively active PKC-theta, but not other constitutively active PKCs (alpha, delta, epsilon or zeta), were capable of activating an NF-kB reporter. Co-transfection experiments indicated that constitutively active PKC-theta upregulates the activity of IKKbeta, but not IKKalpha. Although a biochemical association between PKC-theta and IKKbeta could not be detected, the data suggest that PKC-theta directly or indirectly modulates IKKbeta kinase activity, thus regulating NF-kB.
PubMed:10733597
TNRF signaling
GO:0007250
IMR:0000242
IMR:0000243
event
IEV:0001373
Phosphorylation of IKK complex by NIK in cytosol
TNRF signaling
XX:<new dbxref>
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050856
event
IEV:0001374
Regulation of T cell receptor signaling pathway
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050856
Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050860
event
IEV:0001375
Negative regulation of T cell receptor signaling pathway
Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050860
Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050862
event
IEV:0001376
Positive regulation of T cell receptor signaling pathway
Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
GO:0050862
IMR:0000008
IMR:0000382
PubMed:11973130
event
IEV:0001377
Transcription of IL-2 by NF-kappaB in nucleus
IMR:0000232
IMR:0100459
PubMed:15125833
event
IEV:0001378
Phosphorylation of IKK beta by TAK1 in cytosol
event
IEV:0001379
IKK activation signaling
IMR:0002662
PubMed:15125833
event
IEV:0001380
Oligomerization of MALT1 in cytosol
IMR:0100427
PubMed:15125833
event
IEV:0001381
Oligomerization of TRAF6 in cytosol
IMR:0002662
IMR:0100427
PubMed:15125833
event
IEV:0001382
Binding of MALT1 and TRAF6 in cytosol
IMR:0002658
IMR:0002662
PubMed:15125833
event
IEV:0001383
Binding of BCL10 and MALT1 in cytosol
IMR:0000232
IMR:0100427
PubMed:15125833
event
IEV:0001384
Activation of TAK1 by ubiquitinated TRAF6 in cytosol
IMR:0002655
IMR:0002658
IMR:0100484
PubMed:15125833
event
IEV:0001385
Recruitment of CARMA1 and BCL10 to the lipid raft of the synapse by PKC theta
event
IEV:0001386
Recruitment to the raft
event
IEV:0001387
IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
IMR:0100427
PubMed:15125833
event
IEV:0001388
Ubiquitination of TRAF6 by TRAF6 in cytosol
IMR:0001164
IMR:0100427
PubMed:15125833
event
IEV:0001389
Ubiquitination of NEMO by TRAF6 in cytosol
IMR:0000232
PubMed:15125833
event
IEV:0001390
Autophosphorylation of TAK1 in cytosol
PubMed:15343367
event
IEV:0001391
PKC theta activation signaling
event
IEV:0001392
cPKC activation signaling
IMR:0100031
IMR:0100486
PubMed:10506570
PubMed:7499357
event
IEV:0001393
Binding of calcium ion and cPKC and active conformational change of cPKC in cytosol
IMR:0100027
IMR:0100486
PubMed:7499357
event
IEV:0001394
Binding of DAG and cPKC and active conformational change of cPKC in cytosol
IMR:0100027
IMR:0100031
IMR:0100486
PubMed:7499357
event
IEV:0001395
Binding of DAG, calcium ion and cPKC and active conformational change of cPKC in cytosol
IMR:0100451
IMR:0700610
event
IEV:0001396
Activation of MEKK3 by RIP1 in cytosol
KEGG:hsa04210
KEGG:mmu04210
KEGG:rno04210
REACT:900.1
event
IEV:0001397
Fas signaling pathway
IMR:0100318
event
IEV:0001398
Nuclear export of mRNA (Smad7)
IMR:0000710
IMR:0100318
event
IEV:0001399
Binding of Smad7 and TGF beta receptor I in cytosol
Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034121
regulation of TLR signaling pathway
event
IEV:0001400
Regulation of Toll-like receptor pathway
Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034121
Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
GO:0046578
regulation of Ras protein signal transduction
event
IEV:0001401
Regulation of Ras mediated signaling
Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
GO:0046578
regulation of Ras protein signal transduction
GO:0046578
Any process that activates or increases the rate, frequency or extent of Ras protein signal transduction.
GO:0046579
positive regulation of Ras protein signal transduction
event
IEV:0001402
Positive regulation of Ras mediated signaling
Any process that activates or increases the rate, frequency or extent of Ras protein signal transduction.
GO:0046579
positive regulation of Ras protein signal transduction
GO:0046579
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0010564
event
IEV:0001403
Regulation of cell cycle process
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0010564
Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0010948
event
IEV:0001404
Negative regulation of cell cycle process
Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0010948
Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0090068
event
IEV:0001405
Positive regulation of cell cycle process
Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0090068
event
IEV:0001406
Regulation of PDGF signaling pathway
event
IEV:0001407
Regulation of PLC signaling
event
IEV:0001408
Negative regulation of PLC signaling
event
IEV:0001409
Positive regulation of PLC signaling
Alanine metabolism: The chemical reactions and pathways involving alanine, 2-aminopropanoic acid.
Aspartate metabolism: The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
GO:0006522
GO:0006531
KEGG:map00250
event
IEV:0001410
Alanine and aspartate metabolism
Alanine metabolism: The chemical reactions and pathways involving alanine, 2-aminopropanoic acid.
Aspartate metabolism: The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
GO:0006522
GO:0006531
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
GO:0006536
KEGG:map00250
glutamate metabolic process
glutamic acid metabolic process
glutamic acid metabolism
event
IEV:0001411
Glutamate metabolism
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
GO:0006536
Glycine metabolism: The chemical reactions and pathways involving glycine, aminoethanoic acid.
Serine metabolism: The chemical reactions and pathways involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid.
Threonine metabolism: The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
GO:0006544
GO:0006563
GO:0006566
KEGG:map00260
event
IEV:0001412
Glycine, serine and threonine metabolism
Glycine metabolism: The chemical reactions and pathways involving glycine, aminoethanoic acid.
Serine metabolism: The chemical reactions and pathways involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid.
Threonine metabolism: The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
GO:0006544
GO:0006563
GO:0006566
Glycolysis: The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) in other compounds, including pyruvate.
Gluconeogenesis: The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
GO:0006094
GO:0006096
KEGG:map00010
event
IEV:0001413
Glycolysis and Gluconeogenesis
Glycolysis: The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) in other compounds, including pyruvate.
Gluconeogenesis: The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
GO:0006094
GO:0006096
The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.
GO:0006098
KEGG:map00030
hexose monophosphate pathway
pentose phosphate shunt
pentose-phosphate pathway
pentose-phosphate shunt
event
IEV:0001414
Pentose phosphate pathway
The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.
GO:0006098
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
GO:0006099
KEGG:map00020
Krebs cycle
citric acid cycle
tricarboxylic acid cycle
event
IEV:0001415
Citrate cycle (TCA cycle)
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
GO:0006099
KEGG:map00040
event
IEV:0001416
Pentose and glucuronate interconversions
Fructose metabolism: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
Mannose metabolism: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
GO:0006000
GO:0006013
KEGG:map00051
event
IEV:0001417
Fructose and mannose metabolism
Fructose metabolism: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
Mannose metabolism: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
GO:0006000
GO:0006013
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
GO:0006012
KEGG:map00052
galactose metabolic process
event
IEV:0001418
Galactose metabolism
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
GO:0006012
Ascorbate metabolism: The chemical reactions and pathways involving L-ascorbic acid, a carbohydrate-like vitamin containing six carbon atoms per molecule. Widely distributed in fruit and vegetables.
GO:0019852
KEGG:map00053
event
IEV:0001419
Ascorbate and aldarate metabolism
Ascorbate metabolism: The chemical reactions and pathways involving L-ascorbic acid, a carbohydrate-like vitamin containing six carbon atoms per molecule. Widely distributed in fruit and vegetables.
GO:0019852
Starch metabolism: The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.
Sucrose metabolism: The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.
GO:0005982
GO:0005985
KEGG:map00500
event
IEV:0001420
Starch and sucrose metabolism
Starch metabolism: The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.
Sucrose metabolism: The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.
GO:0005982
GO:0005985
The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group.
GO:0006040
KEGG:map00520
amino sugar metabolic process
amino sugar metabolism
aminosaccharide metabolic process
aminosaccharide metabolism
event
IEV:0001421
Aminosugars metabolism
The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group.
GO:0006040
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
GO:0005975
carbohydrate metabolic process
event
IEV:0001422
Carbohydrate Metabolism
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
GO:0005975
The chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.
GO:0009225
KEGG:map00520
nucleotide-sugar metabolic process
event
IEV:0001423
Nucleotide sugars metabolism
The chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.
GO:0009225
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
GO:0006090
KEGG:map00620
pyruvate metabolic process
event
IEV:0001424
Pyruvate metabolism
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
GO:0006090
Glyoxylate metabolism: The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
Dicarboxylate metabolism: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
GO:0043648
GO:0046487
KEGG:map00630
event
IEV:0001425
Glyoxylate and dicarboxylate metabolism
Glyoxylate metabolism: The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
Dicarboxylate metabolism: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
GO:0043648
GO:0046487
KEGG:map00640
event
IEV:0001426
Propanoate metabolism
KEGG:map00650
event
IEV:0001427
Butanoate metabolism
KEGG:map00660
event
IEV:0001428
C5-Branched dibasic acid metabolism
The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
GO:0006020
KEGG:map00562
inositol metabolic process
vitamin Bh metabolic process
vitamin Bh metabolism
event
IEV:0001429
Inositol metabolism
The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
GO:0006020
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
GO:0043647
KEGG:map00562
inositol phosphate metabolic process
event
IEV:0001430
Inositol phosphate metabolism
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
GO:0043647
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
GO:0006119
KEGG:map00190
respiratory-chain phosphorylation
event
IEV:0001431
Oxidative phosphorylation
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
GO:0006119
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0006754
ATP anabolism
ATP biosynthesis
ATP biosynthetic process
ATP formation
event
IEV:0001432
ATP synthesis
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0006754
The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
GO:0015979
KEGG:map00195
event
IEV:0001433
Photosynthesis
The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
GO:0015979
KEGG:map00710
event
IEV:0001434
Carbon fixation
KEGG:map00720
event
IEV:0001435
Reductive carboxylate cycle (CO2 fixation)
The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes.
GO:0015947
KEGG:map00680
methane metabolic process
event
IEV:0001436
Methane metabolism
The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes.
GO:0015947
KEGG:map00910
event
IEV:0001437
Nitrogen metabolism
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
GO:0006790
KEGG:map00920
sulfur metabolic process
sulphur metabolic process
sulphur metabolism
event
IEV:0001438
Sulfur metabolism
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
GO:0006790
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
GO:0006633
KEGG:map00061
fatty acid anabolism
fatty acid biosynthetic process
fatty acid formation
fatty acid synthesis
event
IEV:0001439
Fatty acid biosynthesis
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
GO:0006633
Fatty acid elongation: The elongation of a fatty acid chain by the sequential addition of two-carbon units.
GO:0030497
KEGG:map00062
event
IEV:0001440
Fatty acid elongation in mitochondria
Fatty acid elongation: The elongation of a fatty acid chain by the sequential addition of two-carbon units.
GO:0030497
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
GO:0006631
KEGG:map00071
fatty acid metabolic process
event
IEV:0001441
Fatty acid metabolism
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
GO:0006631
The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.
GO:0046950
KEGG:map00072
ketone body metabolic process
event
IEV:0001442
Ketone bodies metabolism
The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.
GO:0046950
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
GO:0006694
KEGG:map00100
steroid anabolism
steroid biosynthetic process
steroid formation
steroid synthesis
steroidogenesis
event
IEV:0001443
Steroid biosynthesis
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
GO:0006694
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
GO:0006699
KEGG:map00120
bile acid anabolism
bile acid biosynthetic process
bile acid formation
bile acid synthesis
event
IEV:0001444
Bile acid biosynthesis
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
GO:0006699
The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
GO:0008207
KEGG:map00140
C21-steroid hormone metabolic process
event
IEV:0001445
C21-Steroid hormone metabolism
The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
GO:0008207
KEGG:map00140
event
IEV:0001446
Steroid hormone biosynthesis
The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.
GO:0046486
KEGG:map00561
glycerolipid metabolic process
event
IEV:0001447
Glycerolipid metabolism
The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.
GO:0046486
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
GO:0006650
KEGG:map00564
glycerophospholipid metabolic process
phosphoglyceride metabolic process
phosphoglyceride metabolism
event
IEV:0001448
Glycerophospholipid metabolism
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
GO:0006650
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
GO:0019369
KEGG:map00590
event
IEV:0001449
Prostaglandin and leukotriene metabolism
Arachidonic acid metabolism
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
GO:0019369
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
GO:0006163
KEGG:map00230
purine nucleotide metabolism
event
IEV:0001450
Purine metabolism
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
GO:0006163
The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
GO:0006220
KEGG:map00240
pyrimidine nucleotide metabolism
event
IEV:0001451
Pyrimidine metabolism
The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
GO:0006220
true
true
Valine degradation: The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
Leucine degradation: The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
Isoleucine degradation: The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
GO:0006550
GO:0006552
GO:0006574
KEGG:map00280
event
IEV:0001454
Valine, leucine and isoleucine degradation
Valine degradation: The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
Leucine degradation: The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
Isoleucine degradation: The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
GO:0006550
GO:0006552
GO:0006574
Valine biosynthesis: The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
Leucine biosynthesis: The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
Isoleucine biosynthesis: The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
GO:0009097
GO:0009098
GO:0009099
KEGG:map00290
event
IEV:0001455
Valine, leucine and isoleucine biosynthesis
Valine biosynthesis: The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
Leucine biosynthesis: The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
Isoleucine biosynthesis: The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
GO:0009097
GO:0009098
GO:0009099
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
GO:0009085
KEGG:map00300
lysine anabolism
lysine biosynthetic process
lysine formation
lysine synthesis
event
IEV:0001456
Lysine biosynthesis
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
GO:0009085
The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.
GO:0006554
KEGG:map00310
lysine breakdown
lysine catabolic process
lysine catabolism
event
IEV:0001457
Lysine degradation
The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.
GO:0006554
Arginine metabolism: The chemical reactions and pathways involving arginine, 2-amino-5-guanidinopentanoic acid. Proline metabolism: The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
GO:0006525
GO:0006560
KEGG:map00330
event
IEV:0001458
Arginine and proline metabolism
Arginine metabolism: The chemical reactions and pathways involving arginine, 2-amino-5-guanidinopentanoic acid. Proline metabolism: The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
GO:0006525
GO:0006560
The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
GO:0006547
KEGG:map00340
histidine metabolic process
event
IEV:0001459
Histidine metabolism
The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
GO:0006547
The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
GO:0006570
KEGG:map00350
tyrosine metabolic process
event
IEV:0001460
Tyrosine metabolism
The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
GO:0006570
L-phenylalanine metabolism: The chemical reactions and pathways involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid.
GO:0006558
KEGG:map00360
event
IEV:0001461
Phenylalanine metabolism
L-phenylalanine metabolism: The chemical reactions and pathways involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid.
GO:0006558
The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
GO:0006568
KEGG:map00380
tryptophan metabolic process
event
IEV:0001462
Tryptophan metabolism
The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
GO:0006568
L-phenylalanine biosynthesis: The chemical reactions and pathways resulting in the formation of L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid.
IEV:0000410
GO:0009094
KEGG:map00400
Phenylalanine biosynthesis pathway
event
IEV:0001463
Phenylalanine biosynthesis
L-phenylalanine biosynthesis: The chemical reactions and pathways resulting in the formation of L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid.
GO:0009094
A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
GO:0000050
KEGG:map00330
event
IEV:0001464
Urea cycle and metabolism of amino groups
A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
GO:0000050
The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
GO:0019482
KEGG:map00410
beta-alanine metabolic process
event
IEV:0001465
beta-Alanine metabolism
The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
GO:0019482
Methionine metabolism: The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
Cysteine metabolism: The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.
IEV:0001452
IEV:0001453
GO:0006534
GO:0006555
KEGG:map00270
KEGG:map00430
event
IEV:0001466
Methionine and Cysteine metabolism
Methionine metabolism: The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
Cysteine metabolism: The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.
GO:0006534
GO:0006555
The chemical reactions and pathways involving aminophosphonates, amino acid derivatives that contain a phosphonic acid moiety.
GO:0033051
aminophosphonate metabolic process
event
IEV:0001467
Aminophosphonate metabolism
The chemical reactions and pathways involving aminophosphonates, amino acid derivatives that contain a phosphonic acid moiety.
GO:0033051
KEGG:map00450
event
IEV:0001468
Selenoamino acid metabolism
The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group.
GO:0033052
KEGG:map00460
cyanoamino acid metabolic process
event
IEV:0001469
Cyanoamino acid metabolism
The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group.
GO:0033052
D-glutamine metabolism:The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid.
D-glutamate metabolism:The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid.
GO:0033053
GO:0033054
KEGG:map00471
event
IEV:0001470
D-Glutamine and D-glutamate metabolism
D-glutamine metabolism:The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid.
D-glutamate metabolism:The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid.
GO:0033053
GO:0033054
D-arginine metabolism:The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid.
D-ornithine metabolism:The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.
GO:0033055
GO:0033056
KEGG:map00472
event
IEV:0001471
D-Arginine and D-ornithine metabolism
D-arginine metabolism:The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid.
D-ornithine metabolism:The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.
GO:0033055
GO:0033056
The chemical reactions and pathways involving D-alanine, the dextrorotatory isomer of the amino acid alanine.
GO:0046436
KEGG:map00473
D-alanine metabolic process
event
IEV:0001472
D-Alanine metabolism
The chemical reactions and pathways involving D-alanine, the dextrorotatory isomer of the amino acid alanine.
GO:0046436
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
GO:0006749
KEGG:map00480
glutathione metabolic process
event
IEV:0001473
Glutathione metabolism
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
GO:0006749
KEGG:map00510
event
IEV:0001474
N-Glycan biosynthesis
KEGG:map00513
event
IEV:0001475
High-mannose type N-glycan biosynthesis
KEGG:map00511
event
IEV:0001476
N-Glycan degradation
KEGG:map00512
event
IEV:0001477
O-Glycan biosynthesis
The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
GO:0030206
KEGG:map00532
chondroitin sulfate anabolism
chondroitin sulfate biosynthetic process
chondroitin sulfate formation
chondroitin sulfate synthesis
chondroitin sulphate biosynthesis
event
IEV:0001478
Chondroitin sulfate biosynthesis
The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
GO:0030206
PubMed:12121659
CD28 Costimulation
event
IEV:0001479
CD28 signaling
CD28 Costimulation
PubMed:12121659
IMR:0000211
IMR:0000473
PubMed:12121659
event
IEV:0001480
Phosphorylation of CD28 by Src family in cytosol
IMR:0000473
IMR:0100353
PubMed:12121659
event
IEV:0001481
Phosphorylation of CD28 by Lck in cytosol
IMR:0000473
IMR:0100352
PubMed:12121659
event
IEV:0001482
Phosphorylation of CD28 by Fyn in cytosol
IMR:0000265
IMR:0000473
event
IEV:0001483
Binding of CD28 and PI3K in cytosol
PubMed:10485710
PI3K-AKT signaling
event
IEV:0001484
AKT(PKB) activation signaling
PI3K-AKT signaling
PubMed:10485710
event
IEV:0001485
Regulation of AKT(PKB) activation signaling
event
IEV:0001486
Negative regulation of AKT(PKB) activation signaling
event
IEV:0001487
Positive regulation of AKT(PKB) activation signaling
IMR:0001352
IMR:0100701
event
IEV:0001488
Dephosphorylation of PIP3 by PTEN in plasma membrane
The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
GO:0018146
KEGG:map00533
keratan sulfate anabolism
keratan sulfate biosynthetic process
keratan sulfate formation
keratan sulfate synthesis
keratan sulphate biosynthesis
keratan sulphate biosynthetic process
event
IEV:0001489
Keratan sulfate biosynthesis
The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
GO:0018146
The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars.
GO:0006027
KEGG:map00531
glycosaminoglycan breakdown
glycosaminoglycan catabolic process
glycosaminoglycan catabolism
event
IEV:0001490
Glycosaminoglycan degradation
The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars.
GO:0006027
The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
GO:0009103
KEGG:map00540
lipopolysaccharide anabolism
lipopolysaccharide biosynthetic process
lipopolysaccharide formation
lipopolysaccharide synthesis
event
IEV:0001491
Lipopolysaccharide biosynthesis
The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
GO:0009103
The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
GO:0009252
KEGG:map00550
murein biosynthesis
murein biosynthetic process
peptidoglycan anabolism
peptidoglycan biosynthetic process
peptidoglycan formation
peptidoglycan synthesis
event
IEV:0001492
Peptidoglycan biosynthesis
The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
GO:0009252
The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.
GO:0006506
KEGG:map00563
GPI anchor anabolism
GPI anchor biosynthetic process
GPI anchor formation
GPI anchor synthesis
glycosylphosphatidylinositol biosynthesis
glycosylphosphatidylinositol biosynthetic process
event
IEV:0001493
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.
GO:0006506
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
GO:0006665
KEGG:map00600
sphingolipid metabolic process
event
IEV:0001494
Sphingolipid metabolism
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
GO:0006665
KEGG:map00601
event
IEV:0001495
Glycosphingolipid biosynthesis-lactoseries
KEGG:map00601
event
IEV:0001496
Glycosphingolipid biosynthesis-neo-lactoseries
The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.
GO:0001575
KEGG:map00603
globoside metabolic process
globoside metabolism
event
IEV:0001497
Glycosphingolipid biosynthesis-globoseries
The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.
GO:0001575
The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
GO:0001574
KEGG:map00604
ganglioside anabolism
ganglioside biosynthesis
ganglioside biosynthetic process
ganglioside formation
ganglioside synthesis
event
IEV:0001498
Glycosphingolipid biosynthesis-ganglioseries
The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
GO:0001574
KEGG:map01055
event
IEV:0001499
Biosynthesis of vancomycin group antibiotics
KEGG:map00522
event
IEV:0001500
Biosynthesis of 12-, 14- and 16-membered macrolides
The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.
GO:0033070
KEGG:map01051
ansamycin anabolism
ansamycin biosynthesis
ansamycin biosynthetic process
ansamycin formation
ansamycin synthesis
event
IEV:0001501
Biosynthesis of ansamycins
The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.
GO:0033070
KEGG:map01056
event
IEV:0001502
Biosynthesis of type II polyketide backbone
KEGG:map01057
event
IEV:0001503
Biosynthesis of type II polyketide products
KEGG:map00523
event
IEV:0001504
Polyketide sugar unit biosynthesis
The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
GO:0031623
event
IEV:0001505
Receptor internalization
The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
GO:0031623
KEGG:map01053
event
IEV:0001506
Biosynthesis of siderophore group nonribosomal peptides
The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
GO:0006772
KEGG:map00730
thiamin metabolic process
thiamin metabolism
thiamine metabolic process
vitamin B1 metabolic process
vitamin B1 metabolism
event
IEV:0001507
Thiamine metabolism
The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
GO:0006772
The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
GO:0006771
KEGG:map00740
riboflavin metabolic process
vitamin B2 metabolic process
vitamin B2 metabolism
vitamin G metabolic process
vitamin G metabolism
event
IEV:0001508
Riboflavin metabolism
The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
GO:0006771
The chemical reactions and pathways involving any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.
GO:0042816
KEGG:map00750
vitamin B6 metabolic process
event
IEV:0001509
Vitamin B6 metabolism
The chemical reactions and pathways involving any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.
GO:0042816
Nicotinamide metabolism: The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms.
GO:0006769
GO:0046497
KEGG:map00760
event
IEV:0001510
Nicotinate and nicotinamide metabolism
Nicotinamide metabolism: The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms.
GO:0006769
The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.
GO:0015940
KEGG:map00770
pantothenate anabolism
pantothenate biosynthetic process
pantothenate formation
pantothenate synthesis
vitamin B5 biosynthesis
vitamin B5 biosynthetic process
event
IEV:0001511
Pantothenate biosynthesis
The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.
GO:0015940
The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
GO:0006768
KEGG:map00780
biotin metabolic process
vitamin B7 metabolic process
vitamin B7 metabolism
vitamin H metabolic process
vitamin H metabolism
event
IEV:0001512
Biotin metabolism
The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
GO:0006768
true
The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
IEV:0001513
GO:0046655
KEGG:map00670
KEGG:map00790
folate metabolic process
folic acid metabolic process
folic acid metabolism
vitamin B9 metabolic process
vitamin B9 metabolism
vitamin M metabolic process
vitamin M metabolism
event
IEV:0001514
Folate metabolism
The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
GO:0046655
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
GO:0042572
KEGG:map00830
retinol metabolic process
vitamin A1 alcohol metabolic process
vitamin A1 alcohol metabolism
vitamin A1 metabolic process
vitamin A1 metabolism
event
IEV:0001515
Retinol metabolism
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
GO:0042572
Porphyrin metabolism: The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.
Chlorophyll metabolism: The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment.
GO:0006778
GO:0015994
KEGG:map00860
event
IEV:0001516
Porphyrin and chlorophyll metabolism
Porphyrin metabolism: The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.
Chlorophyll metabolism: The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment.
GO:0006778
GO:0015994
The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
GO:0006744
KEGG:map00130
coenzyme Q biosynthesis
coenzyme Q biosynthetic process
ubiquinone anabolism
ubiquinone biosynthetic process
ubiquinone formation
ubiquinone synthesis
event
IEV:0001517
Ubiquinone biosynthesis
The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
GO:0006744
The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
GO:0016114
KEGG:map00900
terpenoid anabolism
terpenoid biosynthetic process
terpenoid formation
terpenoid synthesis
event
IEV:0001518
Terpenoid biosynthesis
The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
GO:0016114
The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton.
GO:0016099
KEGG:map00902
monoterpenoid anabolism
monoterpenoid biosynthetic process
monoterpenoid formation
monoterpenoid synthesis
event
IEV:0001519
Monoterpenoid biosynthesis
The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton.
GO:0016099
Limonene degradation: The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene.
alpha-pinene degradation: The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature.
GO:0046249
GO:0046251
KEGG:map00903
event
IEV:0001520
Limonene and pinene degradation
Limonene degradation: The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene.
alpha-pinene degradation: The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature.
GO:0046249
GO:0046251
The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units.
GO:0016102
KEGG:map00904
diterpenoid anabolism
diterpenoid biosynthetic process
diterpenoid formation
diterpenoid synthesis
event
IEV:0001521
Diterpenoid biosynthesis
The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units.
GO:0016102
Indole biosynthesis: The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).
GO:0042432
KEGG:map00901
event
IEV:0001522
Indole and ipecac alkaloid biosynthesis
Indole biosynthesis: The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).
GO:0042432
Stilbene biosynthesis: The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA.
Coumarin biosynthesis: The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids. Lignin biosynthesis: The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers.
GO:0009805
GO:0009809
GO:0009811
event
IEV:0001523
Stilbene, coumarine and lignin biosynthesis
Stilbene biosynthesis: The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA.
Coumarin biosynthesis: The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids. Lignin biosynthesis: The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers.
GO:0009805
GO:0009809
GO:0009811
The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton.
GO:0009813
KEGG:map00941
flavonoid anabolism
flavonoid biosynthetic process
flavonoid formation
flavonoid synthesis
event
IEV:0001524
Flavonoid biosynthesis
The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton.
GO:0009813
The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases).
IEV:0001526
GO:0009821
KEGG:map00950
KEGG:map00960
KEGG:map01058
alkaloid anabolism
alkaloid biosynthetic process
alkaloid formation
alkaloid synthesis
event
IEV:0001525
Alkaloid biosynthesis
The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases).
GO:0009821
true
Penicillin biosynthesis: The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Cephalosporin biosynthesis: The formation from simpler components of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria.
GO:0042318
GO:0043646
KEGG:map00311
event
IEV:0001527
Penicillins and cephalosporins biosynthesis
Penicillin biosynthesis: The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Cephalosporin biosynthesis: The formation from simpler components of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria.
GO:0042318
GO:0043646
KEGG:map00312
event
IEV:0001528
beta-Lactam resistanse
The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.
GO:0019872
KEGG:map00521
streptomycin anabolism
streptomycin biosynthetic process
streptomycin formation
streptomycin synthesis
event
IEV:0001529
Streptomycin biosynthesis
The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.
GO:0019872
The formation from simpler components of tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).
GO:0043644
KEGG:map00253
tetracyclin biosynthesis
tetracycline biosynthetic process
event
IEV:0001530
Tetracycline biosynthesis
The formation from simpler components of tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).
GO:0043644
The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.
GO:0033050
KEGG:map00331
clavulanic acid anabolism
clavulanic acid biosynthetic process
clavulanic acid formation
clavulanic acid synthesis
event
IEV:0001531
Clavulanic acid biosynthesis
The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.
GO:0033050
The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger.
GO:0043638
KEGG:map00231
puromycin biosynthetic process
event
IEV:0001532
Puromycin biosynthesis
The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger.
GO:0043638
The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase.
GO:0043642
KEGG:map00401
novobiocin biosynthetic process
event
IEV:0001533
Novobiocin biosynthesis
The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase.
GO:0043642
The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid.
GO:0019384
KEGG:map00930
caprolactam breakdown
caprolactam catabolic process
caprolactam catabolism
event
IEV:0001534
Caprolactam degradation
The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid.
GO:0019384
The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs).
GO:0070980
KEGG:map00621
biphenyl breakdown
biphenyl catabolic process
biphenyl catabolism
event
IEV:0001535
Biphenyl degradation
The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs).
GO:0070980
Toluene degradation: The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.
Xylene degradation: The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene.
GO:0042184
GO:0042203
KEGG:map00622
event
IEV:0001536
Toluene and xylene degradation
Toluene degradation: The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.
Xylene degradation: The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene.
GO:0042184
GO:0042203
GO:0018919
KEGG:map00361
event
IEV:0001537
gamma-Hexachlorocyclohexane degradation
GO:0018888
KEGG:map00641
event
IEV:0001538
3-Chloroacrylic acid degradation
The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide.
GO:0042188
KEGG:map00351
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism
DDT catabolic process
DDT catabolism
event
IEV:0001539
1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane degradation
The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide.
GO:0042188
The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs).
GO:0046298
KEGG:map00623
2,4-dichlorobenzoate breakdown
2,4-dichlorobenzoate catabolic process
2,4-dichlorobenzoate catabolism
event
IEV:0001540
2,4-Dichlorobenzoate degradation
The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs).
GO:0046298
The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride.
GO:0019260
KEGG:map00631
1,2-dichloroethane breakdown
1,2-dichloroethane catabolic process
1,2-dichloroethane catabolism
event
IEV:0001541
1,2-Dichloroethane degradation
The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride.
GO:0019260
The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines.
GO:0019337
KEGG:map00625
tetrachloroethene catabolic process
tetrachloroethene catabolism
tetrachloroethylene breakdown
tetrachloroethylene catabolic process
tetrachloroethylene catabolism
tetrachloroethylene degradation
event
IEV:0001542
Tetrachloroethene degradation
The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines.
GO:0019337
The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene.
GO:0042207
KEGG:map00643
styrene breakdown
styrene catabolic process
styrene catabolism
event
IEV:0001543
Styrene degradation
The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene.
GO:0042207
The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring.
GO:0019261
KEGG:map00627
1,4-dichlorobenzene breakdown
1,4-dichlorobenzene catabolic process
1,4-dichlorobenzene catabolism
event
IEV:0001544
1,4-Dichlorobenzene degradation
The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring.
GO:0019261
GO:0018916
KEGG:map00626
event
IEV:0001545
Nitrobenzene degradation
The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen.
GO:0010130
KEGG:map00642
event
IEV:0001546
Ethylbenzene degradation
The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen.
GO:0010130
The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents.
GO:0019429
KEGG:map00628
fluorene breakdown
fluorene catabolic process
fluorene catabolism
event
IEV:0001547
Fluorene degradation
The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents.
GO:0019429
The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen.
GO:0046232
KEGG:map00629
carbazole breakdown
carbazole catabolic process
carbazole catabolism
event
IEV:0001548
Carbazole degradation
The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen.
GO:0046232
The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway.
GO:0010128
KEGG:map00632
anaerobic benzoate breakdown
anaerobic benzoate catabolic process
anaerobic benzoate catabolism
anaerobic benzoate degradation
benzoate catabolic process via CoA ligation
event
IEV:0001549
Benzoate degradation via CoA ligation
The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway.
GO:0010128
The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol.
GO:0043640
KEGG:map00362
benzoate breakdown via hydroxylation
benzoate catabolic process via hydroxylation
event
IEV:0001550
Benzoate degradation via hydroxylation
The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol.
GO:0043640
The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide.
GO:0019381
KEGG:map00791
atrazine breakdown
atrazine catabolic process
atrazine catabolism
event
IEV:0001551
Atrazine degradation
The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide.
GO:0019381
event
IEV:0001552
Energy Metabolism
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
GO:0006629
KEGG:map01130
lipid metabolic process
event
IEV:0001553
Lipid Metabolism
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
GO:0006629
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
GO:0009117
nucleotide metabolic process
event
IEV:0001554
Nucleotide Metabolism
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
GO:0009117
Cofactor metabolism: The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
Vitamin metabolism: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
GO:0006766
GO:0051186
event
IEV:0001555
Metabolism of Cofactors and Vitamins
Cofactor metabolism: The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
Vitamin metabolism: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
GO:0006766
GO:0051186
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
GO:0006520
amino acid metabolic process
event
IEV:0001556
Amino Acid Metabolism
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
GO:0006520
The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
GO:0006575
event
IEV:0001557
Amino acid derivative metabolism
The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
GO:0006575
Glycan biosynthesis: The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.
Glycan metabolism: The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages.
GO:0000271
GO:0005976
event
IEV:0001558
Glycan Biosynthesis and Metabolism
Glycan biosynthesis: The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.
Glycan metabolism: The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages.
GO:0000271
GO:0005976
The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps.
GO:0030639
polyketide anabolism
polyketide biosynthetic process
polyketide formation
polyketide synthesis
event
IEV:0001559
Polyketide biosynthesis
The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps.
GO:0030639
event
IEV:0001560
Biosynthesis of Secondary Metabolites
Xenobiotic degradation: The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
Xenobiotic metabolism: The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
GO:0006805
GO:0042178
event
IEV:0001561
Xenobiotics Biodegradation and Metabolism
Xenobiotic degradation: The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
Xenobiotic metabolism: The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
GO:0006805
GO:0042178
event
IEV:0001562
Osmotic pressure treatment
event
IEV:0001563
Humidity treatment
event
IEV:0001564
High osmotic pressure treatment
event
IEV:0001565
Heat shock treatment
event
IEV:0001566
Anticancer drug medication
event
IEV:0001567
Protein synthesis inhibitor medication
event
IEV:0001568
Ultraviolet irradiation
event
IEV:0001569
Cyclohexemide medication
event
IEV:0001570
Proteasome inhibitor medication
event
IEV:0001571
Transcription inhibitor medication
event
IEV:0001572
DRB medication
event
IEV:0001573
Hydrogen peroxide treatment
event
IEV:0001574
Abscisic acid stimulus
event
IEV:0001575
Auxin stimulus
event
IEV:0001576
Sorbitol treatment
event
IEV:0001577
Brassinosteroid stimulus
event
IEV:0001578
Cytokinin stimulus
event
IEV:0001579
Ethylene stimulus
event
IEV:0001580
Gibberellic acid stimulus
event
IEV:0001581
Carbohydrate treatment
event
IEV:0001582
Hexose treatment
event
IEV:0001583
Sucrose treatment
event
IEV:0001584
Fructose treatment
event
IEV:0001585
Glucose treatment
event
IEV:0001586
Anisomycin medication
event
IEV:0001587
Puromycin medication
event
IEV:0001588
Actinomycin medication
PubMed:15034556
event
IEV:0001589
Src family activation signaling
PubMed:11781344
event
IEV:0001590
Src family inactivation signaling
IMR:0000682
IMR:0100353
PubMed:15034556
event
IEV:0001591
Phosphorylation of Lck by non-receptor kinase and inactive conformational change in cytosol
IMR:0000273
IMR:0100353
PubMed:15034556
Dephosphorylation of Lck_p (autophosphorylated) by PTP in cytosol
event
IEV:0001592
Dephosphorylation of Lck_p by PTP in cytosol
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
event
IEV:0001593
Interaction in the inner space of the nuclear
true
OBSOLETE: remap to 'Unknown interaction' IEV:0000922.
XX:<new dbxref>
IMR:0000273
IMR:0100352
PubMed:15034556
Dephosphorylation of Fyn_p (autophosphorylated) by PTP in cytosol
event
IEV:0001594
Dephosphorylation of Fyn_p by PTP in cytosol
event
IEV:0001595
Protein involved in DNA fragmentation and chromatin condensation signaling
true
IMR:0000682
IMR:0100352
PubMed:15034556
event
IEV:0001596
Phosphorylation of Fyn by non-receptor kinase and inactive conformational change in cytosol
IMR:0000211
PubMed:15034556
event
IEV:0001597
Phosphorylation of Src family by Csk and inactive conformational change in cytosol
IMR:0000273
IMR:0100352
PubMed:15034556
Dephosphorylation of Fyn_p (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol
event
IEV:0001598
Dephosphorylation of Fyn_p by PTP and active conformational change in cytosol
IMR:0000273
IMR:0100353
PubMed:15034556
Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by PTP and active conformational change in cytosol
event
IEV:0001599
Dephosphorylation of Lck_p by PTP and active conformational change in cytosol
IMR:0000275
IMR:0100575
PubMed:15034556
PubMed:9261115
Dephosphorylation of Src (phosphorylated in the C-terminal site) by SHP-1 and active conformational change
event
IEV:0001600
Dephosphorylation of Src_p by SHP-1 and active conformational change
IMR:0000276
IMR:0100575
PubMed:15034556
PubMed:7478513
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP1D and active conformational change
event
IEV:0001601
Dephosphorylation of Src_p by SHP-2 and active conformational change
event
IEV:0001602
EndoG mediated signaling
event
IEV:0001603
CAD signaling
IMR:0100659
event
IEV:0001604
Gene expression of apoptotic factor by p53
UniProt:Q14249
event
IEV:0001605
Nuclear import of EndoG
IMR:0000273
event
IEV:0001606
Src family activation signaling (through autophosphorylation and PTP)
IMR:0000211
PubMed:15034556
event
IEV:0001607
Autophosphorylation of Src family and active conformational change in cytosol
IMR:0000211
IMR:0000273
PubMed:15034556
Dephosphorylation of Src family (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol
event
IEV:0001608
Dephosphorylation of Src family_p by PTP and active conformational change in cytosol
event
IEV:0001609
Fyn activation signaling
event
IEV:0001610
Lck activation signaling
IMR:0000211
IMR:0000273
PubMed:15034556
Dephosphorylation of Src family (autophosphorylated) by PTP in cytosol
event
IEV:0001611
Dephosphorylation of Src family_p by PTP in cytosol
IMR:0000211
IMR:0000682
PubMed:15034556
event
IEV:0001612
Phosphorylation of Src family by non-receptor kinase and inactive conformational change in cytosol
event
IEV:0001613
Regulation of Fyn activation signaling
event
IEV:0001614
Negative regulation of Fyn activation signaling
event
IEV:0001615
Positive regulation of Fyn activation signaling
event
IEV:0001616
Regulation of Lck activation signaling
event
IEV:0001617
Negative regulation of Lck activation signaling
event
IEV:0001618
Positive regulation of Lck activation signaling
event
IEV:0001619
Regulation of Src activation signaling
event
IEV:0001620
Negative regulation of Src activation signaling
event
IEV:0001621
Positive regulation of Src activation signaling
IMR:0000273
event
IEV:0001622
Regulation of Src family activation signaling (autophosphorylation and PTP)
IMR:0000273
event
IEV:0001623
Negative regulation of Src family activation signaling (autophosphorylation and PTP)
IMR:0000273
event
IEV:0001624
Positive regulation of Src family activation signaling (autophosphorylation and PTP)
event
IEV:0001625
Regulation of src activation signaling (through Estrogen receptor)
event
IEV:0001626
Negative regulation of src activation signaling (through Estrogen receptor)
event
IEV:0001627
Positive regulation of src activation signaling (through Estrogen receptor)
IMR:0000273
event
IEV:0001628
Regulation of Fyn activation signaling (through autophosphorylation and PTP)
IMR:0000273
event
IEV:0001629
Negative regulation of Fyn activation signaling (through autophosphorylation and PTP)
IMR:0000273
event
IEV:0001630
Positive regulation of Fyn activation signaling (autophosphorylation and PTP)
IMR:0000273
event
IEV:0001631
Regulation of Lck activation signaling (autophosphorylation and PTP)
IMR:0000273
event
IEV:0001632
Negative regulation of (dephosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
IMR:0000273
event
IEV:0001633
Positive regulation of Lck activation signaling (autophosphorylation and PTP)
event
IEV:0001634
Fyn inactivation signaling
event
IEV:0001635
Lck inactivation signaling
IMR:0000273
event
IEV:0001636
Src activation signaling (through autophosphorylation and PTP)
p416
IMR:0100575
PubMed:11804588
PubMed:15034556
event
IEV:0001637
Autophosphorylation of Src and active conformational change in cytosol
p416
PubMed:11804588
IMR:0000273
IMR:0100575
PubMed:15034556
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol
event
IEV:0001638
Dephosphorylation of Src_p by PTP and active conformational change in cytosol
IMR:0000273
event
IEV:0001639
Regulation of Src activation signaling (through autophosphorylation and PTP)
IMR:0000273
event
IEV:0001640
Negative regulation of Src activation signaling (through autophosphorylation and PTP)
IMR:0000273
event
IEV:0001641
Positive regulation of Src activation signaling (through autophosphorylation and PTP)
PubMed:15034556
event
IEV:0001642
Src inactivation signaling
IMR:0000273
IMR:0100575
PubMed:15034556
Dephosphorylation of Src (autophosphorylated) by PTP in cytosol
event
IEV:0001643
Dephosphorylation of Src_p by PTP in cytosol
IMR:0000682
IMR:0100575
PubMed:15034556
event
IEV:0001644
Phosphorylation of Src by non-receptor kinase and inactive conformational change in cytosol
IMR:0000212
IMR:0100575
PubMed:12480346
PubMed:15034556
event
IEV:0001645
Phosphorylation of Src by Csk and inactive conformational change in cytosol
IMR:0100575
PubMed:15034556
UniProt:P18433
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP alpha and active conformational change
event
IEV:0001646
Dephosphorylation of Src_p by PTP alpha and active conformational change
IMR:0100575
PubMed:15034556
UniProt:Q92729
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP lambda and active conformational change
event
IEV:0001647
Dephosphorylation of Src_p by PTP lambda and active conformational change
IMR:0100575
PubMed:15034556
UniProt:P18031
Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP1B and active conformational change
event
IEV:0001648
Dephosphorylation of Src_p by PTP1B and active conformational change
UniProt:Q14249
event
IEV:0001649
Permeabilization of mitochondria and Translocation of EndoG from mitochondria to cytosol
IMR:0000452
IMR:0100659
event
IEV:0001650
Gene expression of BAK by p53
IMR:0100289
IMR:0100659
event
IEV:0001651
Gene expression of Bid by p53
IMR:0001210
IMR:0100659
event
IEV:0001652
Gene expression of NOXA by p53
IMR:0001211
IMR:0100659
event
IEV:0001653
Gene expression of PUMA by p53
IMR:0000452
event
IEV:0001654
Nuclear export of mRNA (BAK)
IMR:0100289
event
IEV:0001655
Nuclear export of mRNA (Bid)
IMR:0001210
event
IEV:0001656
Nuclear export of mRNA (NOXA)
IMR:0001211
event
IEV:0001657
Nuclear export of mRNA (PUMA)
IMR:0000452
IMR:0100659
event
IEV:0001658
Transcription of BAK by p53 in nucleus
IMR:0100289
IMR:0100659
event
IEV:0001659
Transcription of Bid by p53 in nucleus
IMR:0001210
event
IEV:0001660
Translation of NOXA in cytosol
IMR:0100659
event
IEV:0001661
Transcription of apoptotic factor by p53 in nucleus
event
IEV:0001662
Translation of apoptotic factor in cytosol
IMR:0000452
event
IEV:0001663
Translation of BAK in cytosol
IMR:0100289
event
IEV:0001664
Translation of Bid in cytosol
IMR:0001211
event
IEV:0001665
Translation of PUMA in cytosol
UniProt:O43464
event
IEV:0001666
Permeabilization of mitochondria and Translocation of OMI from mitochondria to cytosol
event
IEV:0001667
Bcl-2/Bcl-xL inactivation signaling
IMR:0100289
event
IEV:0001668
Relocation of free Bid to cytosol
Any process that activates or increases the frequency, rate or extent of a signaling pathway.
GO:0035468
event
IEV:0001669
Positive signal transduction regulation pathway
Any process that activates or increases the frequency, rate or extent of a signaling pathway.
GO:0035468
Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway.
GO:0035467
event
IEV:0001670
Negative signal transduction regulation pathway
Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway.
GO:0035467
event
IEV:0001671
Negative regulation of PDGF receptor signaling pathway
event
IEV:0001672
Positive regulation of PDGF signaling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034122
negative regulation of TLR signaling pathway
event
IEV:0001673
Negative regulation of Toll-like receptor pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034122
Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034123
positive regulation of TLR signaling pathway
event
IEV:0001674
Positive regulation of Toll-like receptor pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.
GO:0034123
Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway.
GO:0030111
event
IEV:0001675
Regulation of Wnt signaling pathway
Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway.
GO:0030111
Any process that stops, prevents or reduces the rate, frequency or extent of Wnt receptor signaling pathway activity.
GO:0030178
event
IEV:0001676
Negative regulation of Wnt signaling pathway
Any process that stops, prevents or reduces the rate, frequency or extent of Wnt receptor signaling pathway activity.
GO:0030178
Any process that activates or increases the rate, frequency or extent of Wnt receptor signaling pathway activity.
GO:0030177
event
IEV:0001677
Positive regulation of Wnt signaling pathway
Any process that activates or increases the rate, frequency or extent of Wnt receptor signaling pathway activity.
GO:0030177
PubMed:15205477
event
IEV:0001678
Caloric restriction
event
IEV:0001679
Caloric treatment
EC:3.5.1.-
IMR:0010335
PubMed:15205477
UniProt:Q96EB6
event
IEV:0001680
Deacetylation of Ku70 by SIRT1 in nucleus
N6-acetyl-L-lysine or S-acetyl-L-cysteine are cleaved and return K or C residues.
MI:0197
event
IEV:0001681
Deacetylation
N6-acetyl-L-lysine or S-acetyl-L-cysteine are cleaved and return K or C residues.
MI:0197
event
IEV:0001682
Deacetylation in cytosol
event
IEV:0001683
Deacetylation in nucleus
event
IEV:0001684
Deacetylation in unidentified cellular location
event
IEV:0001685
Regulation of caloric restriction - cell survival signaling
event
IEV:0001686
Caloric restriction - cell survival signaling
Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043567
regulation of IGF receptor signaling pathway
regulation of insulin-like growth factor receptor signaling pathwa
event
IEV:0001687
Regulation of IGF signaling pathway
Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043567
regulation of IGF receptor signaling pathway
GO:0043567
regulation of insulin-like growth factor receptor signaling pathwa
GO:0043567
Any process that stops, prevents or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043569
negative regulation of insulin-like growth factor receptor signaling pathway
event
IEV:0001688
Negative regulation of IGF receptor signaling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043569
negative regulation of insulin-like growth factor receptor signaling pathway
GO:0043569
Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043568
positive regulation of IGF receptor signaling pathway
positive regulation of insulin-like growth factor receptor signaling pathway
event
IEV:0001689
Positive regulation of IGF signaling pathway
Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.
GO:0043568
positive regulation of IGF receptor signaling pathway
GO:0043568
positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043568
event
IEV:0001690
Negative regulation of caloric restriction - cell survival signaling
event
IEV:0001691
Positive regulation of caloric restriction - cell survival signaling
IMR:0000453
PubMed:15205477
event
IEV:0001692
Translocation of Bax from mitochondria membrane to cytosol
PubMed:11585834
event
IEV:0001693
Endothelin receptor signaling
IMR:0100166
UniProt:P24530
UniProt:P25101
event
IEV:0001694
Binding of endothelin and endothelin receptor in extracellular
Regulation of endothelin receptor signaling pathway
event
IEV:0001695
Regulation of endothelin receptor signaling
Negative regulation of endothelin receptor signaling pathway
event
IEV:0001696
Negative regulation of endothelin receptor signaling
Positive regulation of endothelin receptor signaling pathway
event
IEV:0001697
Positive regulation of endothelin receptor signaling
IMR:0000456
IMR:0001171
IMR:0001173
PubMed:11509672
PubMed:11585834
PubMed:15166223
event
IEV:0001698
Binding of 14-3-3 and HDAC5/7 in cytosol and/or nucleus
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound.
GO:0043491
AKT signaling cascade
PKB signaling cascade
protein kinase B signaling cascade
event
IEV:0001699
AKT signaling
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound.
GO:0043491
AKT signaling cascade
GO:0043491
PKB signaling cascade
GO:0043491
protein kinase B signaling cascade
GO:0043491
IMR:0001171
IMR:0001173
IMR:0100543
PubMed:11509672
PubMed:11585834
PubMed:15166223
event
IEV:0001700
Phosphorylation of HDAC5/7 by CaMK in cytosol and/or nucleus
IMR:0000272
IMR:0001171
IMR:0001173
event
IEV:0001701
Dephosphorylation of HDAC5/7 by protein phosphatase in cytosol
IMR:0000456
IMR:0001090
IMR:0001171
IMR:0001173
PubMed:11509672
PubMed:11585834
event
IEV:0001702
Nuclear export of 14-3-3:HDAC5/7:Crm1
IMR:0001171
IMR:0001173
PubMed:11509672
PubMed:11585834
UniProt:Q02078
event
IEV:0001703
Binding of HDAC5/7 and MEF2 in inner space of nucleus
IMR:0000456
IMR:0001171
IMR:0001173
event
IEV:0001704
Dissociation of 14-3-3 and HDAC5/7 in cytosol
IMR:0001171
IMR:0001173
PubMed:11509672
PubMed:11585834
event
IEV:0001705
Nuclear import of HDAC5/7
IMR:0000456
IMR:0001090
IMR:0001171
IMR:0001173
PubMed:11509672
PubMed:11585834
event
IEV:0001706
Complex formation of 14-3-3:HDAC5/7:Crm1 in inner space of nucleus
event
IEV:0001707
AKT(PKB)-caspase signaling
AKT(PKB)-FKHR signaling
AKT(PKB)-FKHRL1 signaling
event
IEV:0001709
AKT(PKB)-FOXO signaling
IMR:0000250
IMR:0002806
Phosphorylation of FKHRL1 by AKT in inner space of nucleus
event
IEV:0001710
Phosphorylation of FOXO3 by AKT in inner space of nucleus
IMR:0000368
IMR:0001090
PubMed:11509672
event
IEV:0001711
Binding of transcription factor and Crm1 in inner space of nucleus
IMR:0000375
IMR:0001090
PubMed:11509672
event
IEV:0001712
Binding of Stat1 and Crm1 in inner space of nucleus
IMR:0000421
IMR:0001090
PubMed:11509672
event
IEV:0001713
Binding of NFAT and Crm1 in inner space of nucleus
IMR:0000456
IMR:0001090
IMR:0001171
PubMed:11509672
event
IEV:0001714
Complex formation of 14-3-3:HDAC5:Crm1 in inner space of nucleus
IMR:0000456
IMR:0001090
IMR:0001173
PubMed:11585834
event
IEV:0001715
Complex formation of 14-3-3:HDAC7:Crm1 in inner space of nucleus
IMR:0000456
IMR:0001090
IMR:0001171
PubMed:11509672
event
IEV:0001716
Nuclear export of 14-3-3:HDAC5:Crm1
IMR:0000456
IMR:0001090
IMR:0001173
PubMed:11585834
event
IEV:0001717
Nuclear export of 14-3-3:HDAC7:Crm1
IMR:0001171
PubMed:11509672
UniProt:Q02078
event
IEV:0001718
Binding of HDAC5 and MEF2 in inner space of nucleus
PubMed:11509672
event
IEV:0001719
Nuclear import of HDAC5:importin alpha
true
IMR:0001173
PubMed:11585834
UniProt:Q02078
event
IEV:0001720
Binding of HDAC7 and MEF2 in inner space of nucleus
IMR:0000456
IMR:0001171
PubMed:11509672
event
IEV:0001721
Dissociation of 14-3-3 and HDAC5 in cytosol
IMR:0000456
IMR:0001173
PubMed:11585834
event
IEV:0001722
Dissociation of 14-3-3 and HDAC7 in cytosol
IMR:0000272
IMR:0001173
PubMed:11585834
PubMed:15166223
event
IEV:0001723
Dephosphorylation of HDAC7 by protein phosphatase in cytosol
IMR:0000272
IMR:0001171
PubMed:11509672
event
IEV:0001724
Dephosphorylation of HDAC5 by protein phosphatase in cytosol
IMR:0000229
IMR:0100423
PubMed:10485710
event
IEV:0001725
Binding of TRAF2 and MAPKKK in cytosol
IMR:0000242
IMR:0100423
PubMed:10485710
event
IEV:0001726
Binding of TRAF2 and NIK in cytosol
event
IEV:0001727
AKT(PKB)-IKK signaling
IMR:0000250
event
IEV:0001728
Phosphorylation of IKK alpha by AKT(PKB)
event
IEV:0001729
Dephosphorylation in cytosol and/or nucleus
event
IEV:0001730
Binding in cytosol and/or nucleus
CaMK-mediated nuclear export of HDAC5 appears to require binding of 14-3-3 to Ser-259 and Ser-498 in its amino terminus. Indeed, substitution of these serines with alanines blocks both 14-3-3 binding and nuclear export of HDAC5. However, association with 14-3-3 alone is not sufficient to localize HDAC5 in the cytoplasm, since NES mutants of HDAC5 associate with 14-3-3 in a CaMK-dependent manner but remain in the nucleus.
IMR:0000456
IMR:0001171
PubMed:11509672
PubMed:15923258
event
IEV:0001731
Binding of 14-3-3 and HDAC5 in inner space of nucleus
CaMK-mediated nuclear export of HDAC5 appears to require binding of 14-3-3 to Ser-259 and Ser-498 in its amino terminus. Indeed, substitution of these serines with alanines blocks both 14-3-3 binding and nuclear export of HDAC5. However, association with 14-3-3 alone is not sufficient to localize HDAC5 in the cytoplasm, since NES mutants of HDAC5 associate with 14-3-3 in a CaMK-dependent manner but remain in the nucleus.
PubMed:11509672
IMR:0000456
IMR:0001173
PubMed:11585834
PubMed:15166223
event
IEV:0001732
Binding of 14-3-3 and HDAC7 in cytosol and/or nucleus
IMR:0001171
IMR:0100543
PubMed:11509672
event
IEV:0001733
Phosphorylation of HDAC5 by CaMK in inner space of nucleus
IMR:0001173
IMR:0100543
PubMed:11585834
PubMed:15166223
event
IEV:0001734
Phosphorylation of HDAC7 by CaMKI in cytosol
event
IEV:0001735
Phosphorylation in cytosol and/or nucleus
IMR:0000250
IMR:0100737
PubMed:11278246
event
IEV:0001736
Binding of AKT and GSK3beta in cytosol
IMR:0100471
event
IEV:0001737
Gene expression of beta-TrCP
IMR:0000177
IMR:0000205
PubMed:8259519
event
IEV:0001738
Binding of APC and beta catenin in cytosol
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
GO:0031146
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
SCF-dependent proteasomal ubiquitin-dependent protein degradation
event
IEV:0001739
Beta catenin degradation signaling
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
GO:0031146
true
IMR:0000177
IMR:0000310
event
IEV:0001741
Proteasome degradation of beta catenin by 26S proteasome in cytosol
IMR:0000177
IMR:0100737
event
IEV:0001742
Phosphorylation of beta-catenin by GSK3beta in cytosol
IMR:0000250
IMR:0100737
PubMed:11278246
event
IEV:0001743
Phosphorylation of GSK3beta by AKT in cytosol
event
IEV:0001744
GSK3beta inactivation signaling
event
IEV:0001745
AKT(PKB)-GSK3beta signaling
event
IEV:0001746
Regulation of EPO signaling pathway
event
IEV:0001747
Negative regulation of EPO signaling pathway
event
IEV:0001748
Positive regulation of EPO signaling pathway
event
IEV:0001749
Regulation of Growth hormone signaling pathway (JAK2 STAT5)
event
IEV:0001750
Negative regulation of Growth hormone signaling pathway (JAK2 STAT5)
event
IEV:0001751
Positive regulation of Growth hormone signaling pathway (JAK2 STAT5)
Regulation of JAK STAT signaling pathway (Angiotensin induced)
event
IEV:0001752
Regulation of JAK STAT signaling (Angiotensin induced)
Negative regulation of JAK STAT signaling pathway (Angiotensin induced)
event
IEV:0001753
Negative regulation of JAK STAT signaling (Angiotensin induced)
Positive regulation of JAK STAT signaling pathway (Angiotensin induced)
event
IEV:0001754
Positive regulation of JAK STAT signaling (Angiotensin induced)
event
IEV:0001755
Regulation of TPO signaling pathway (through JAK STAT pathway)
event
IEV:0001756
Negative regulation of TPO signaling pathway (through JAK STAT pathway)
event
IEV:0001757
Positive regulation of TPO signaling pathway (through JAK STAT pathway)
IMR:0002926
IMR:0100312
PubMed:12815042
event
IEV:0001761
Sumoylation of Smad3 by PIAS4 in cytosol
IMR:0002914
IMR:0100312
event
IEV:0001762
Negative feedback regulation pathway of TGF beta superfamily signaling by (Smad3 sumoylation by PIAS)
Hep3B cells
IMR:0002926
PubMed:12815042
event
IEV:0001763
Gene expression of PIAS4 (induced by TGF-beta)
Hep3B cells
PubMed:12815042
IMR:0000375
IMR:0002914
PubMed:12855578
event
IEV:0001765
Sumoylation of STAT1 by PIAS in nucleus
IMR:0000374
IMR:0002915
event
IEV:0001767
Negative regulation of JAK STAT pathway by (sumoylation of STAT by PIAS1/3)
IMR:0100035
UniProt:P10275
event
IEV:0001769
Binding of Androgen and Androgen receptor in inner space of nucleus
IGS:0000028
UniProt:P10275
event
IEV:0001770
Binding of Androgen receptor and responsive element in inner space of nucleus
IMR:0100035
event
IEV:0001771
Nuclear import of Androgen
UniProt:P10275
event
IEV:0001772
Transcription by Androgen receptor in nucleus
IMR:0100035
event
IEV:0001773
Translocation of Androgen from extracellular to cytosol
UniProt:P10275
event
IEV:0001774
Binding of Androgen receptor and Hsp90 in cytosol
UniProt:P10275
event
IEV:0001775
Nuclear import of Androgen receptor:Hsp90
Regulation of Steroid receptor signaling pathway
event
IEV:0001776
Regulation of Steroid receptor signaling
event
IEV:0001777
Negative regulation of Steroid receptor signaling pathway
event
IEV:0001778
Positive regulation of Steroid receptor signaling pathway
Any process that modulates the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033146
event
IEV:0001779
Regulation of Estrogen receptor signaling pathway
Any process that modulates the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033146
event
IEV:0001780
Regulation of Androgen receptor signaling pathway
event
IEV:0001781
Negative regulation of Androgen receptor signaling pathway
event
IEV:0001782
Positive regulation of Androgen receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033147
event
IEV:0001783
Negative regulation of Estrogen receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033147
Any process that activates or increases the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033148
event
IEV:0001784
Positive regulation of Estrogen receptor signaling pathway
Any process that activates or increases the frequency, rate or extent of the activity of an estrogen receptor signaling pathway.
GO:0033148
IMR:0002926
PubMed:14981544
UniProt:P10275
event
IEV:0001785
Binding of Androgen receptor and PIAS4 in cytosol and/or nucleus
event
IEV:0001786
Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor
IMR:0002926
PubMed:14981544
UniProt:P10275
event
IEV:0001787
Sumoylation of Androgen receptor by PIAS4
IMR:0001166
PubMed:14981544
UniProt:P10275
event
IEV:0001788
Binding of Androgen receptor and HDAC in inner space of nucleus
UniProt:P10275
event
IEV:0001789
Homodimerization of Androgen receptor in inner space of nucleus
IMR:0000088
event
IEV:0001790
Homodimerization of Estrogen receptor in inner space of nucleus
event
IEV:0001791
Regulation of calcineurin activation signaling
event
IEV:0001792
Negative regulation of calcineurin activation signaling
event
IEV:0001793
Positive regulation of calcineurin activation signaling
IMR:0000278
KEGG:C01375
event
IEV:0001794
Binding of calcineurin and FK506
IMR:0000212
IMR:0000278
event
IEV:0001795
Binding of calcineurin and CSK
Regulation of CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
event
IEV:0001796
Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
Negative regulation of CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
event
IEV:0001797
Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
IMR:0000421
Positive regulation of CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)
event
IEV:0001798
Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
event
IEV:0001799
Regulation of Bad activation signaling
event
IEV:0001800
Negative regulation of Bad activation signaling
event
IEV:0001801
Positive regulation of Bad activation signaling
IMR:0000250
PubMed:10995457
event
IEV:0001802
Binding of AKT and Hsp90 in cytosol
IMR:0000250
IMR:0000280
PubMed:10995457
event
IEV:0001803
Dephosphorylation of AKT(PKB) by PP2A
IMR:0100755
UniProt:Q969F2
UniProt:Q969G9
event
IEV:0001805
Binding of Naked and DSH in cytosol
IMR:0100755
UniProt:Q9H2H0
event
IEV:0001806
Binding of Idax and DSH in cytosol
event
IEV:0001807
TCF phosphorylation signaling
IMR:0000232
IMR:0000441
PubMed:14687659
PubMed:15733830
event
IEV:0001808
Binding of TAB1 and TAK1 in cytosol
IMR:0000232
IMR:0001164
event
IEV:0001809
Phosphorylation of NLK by TAK1 in cytosol
IMR:0000418
IMR:0001164
event
IEV:0001810
Phosphorylation of TCF by NLK in cytosol
event
IEV:0001811
Negative feedback regulation of Wnt signaling pathway
IMR:0000177
IMR:0100471
event
IEV:0001812
Binding of beta catenin and beta-TrCP in cytosol
event
IEV:0001813
Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)
IMR:0000983
PubMed:15549094
event
IEV:0001814
Binding of SFRP and Wnt receptor in extracellular
IMR:0000003
IMR:0002954
PubMed:15549094
event
IEV:0001815
Binding of Wnt and LRP5/6 in extracellular
IMR:0000003
PubMed:15549094
event
IEV:0001816
Binding of Wnt and Wnt receptor in extracellular
IMR:0000989
PubMed:15549094
event
IEV:0001817
Binding of WIF and Wnt receptor in extracellular
IMR:0000991
PubMed:15549094
event
IEV:0001818
Binding of Dkk and Wnt receptor in extracellular
IMR:0000177
IMR:0000418
IMR:0001178
IMR:0001179
PubMed:15549094
event
IEV:0001819
Complex formation of beta catenin, TCF/LEF, Legless, Pygopus, etc. in inner space of nucleus
The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products.
GO:0008015
event
IEV:0001820
Blood circulation
The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products.
GO:0008015
Any process that modulates the size of blood vessels.
GO:0050880
event
IEV:0001821
Regulation of blood vessel size
Any process that modulates the size of blood vessels.
GO:0050880
A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.
GO:0042310
Negative regulation of blood vessel size
event
IEV:0001822
Vasoconstriction
A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.
GO:0042310
Negative regulation of blood vessel size
GO:0042310
The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.
GO:0042692
event
IEV:0001823
Muscle cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.
GO:0042692
The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
GO:0051145
nonstriated muscle cell differentiation
event
IEV:0001824
Smooth muscle cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
GO:0051145
nonstriated muscle cell differentiation
GO:0051145
IMR:0000375
IMR:0000377
IMR:0000378
IMR:0002914
PubMed:14607831
event
IEV:0001825
Sumoylation of STAT1/3/4 by PIAS in nucleus
IMR:0000375
IMR:0000377
IMR:0000378
IMR:0002915
IMR:0002922
PubMed:14607831
event
IEV:0001826
Sumoylation of STAT1/3/4 by PIAS1/3 in nucleus
IMR:0000375
IMR:0000377
IMR:0000378
IMR:0002918
IMR:0002926
PubMed:14607831
event
IEV:0001827
Sumoylation of STAT1/3/4 by PIAS2/4 in nucleus
event
IEV:0001828
SUMOylation in cytosol and/or nucleus
event
IEV:0001829
SUMOylation in nucleus
IMR:0002914
PubMed:15021887
event
IEV:0001831
Sumoylation of trans-activator by PIAS in nucleus
PubMed:15021887
event
IEV:0001832
Binding of trans-activator and co-repressor in inner space of nucleus
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
GO:0045449
event
IEV:0001833
Regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
GO:0045449
Any process that activates or increases the frequency, rate or extent of transcription.
GO:0045941
up regulation of transcription
event
IEV:0001834
Positive regulation of transcription
Any process that activates or increases the frequency, rate or extent of transcription.
GO:0045941
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010468
event
IEV:0001835
Regulation of gene expression
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010468
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010628
event
IEV:0001836
Positive regulation of gene expression
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010628
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010629
event
IEV:0001837
Negative regulation of gene expression
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GO:0010629
Any process that stops, prevents or reduces the frequency, rate or extent of transcription.
GO:0016481
down regulation of transcription
event
IEV:0001838
Negative regulation of transcription
Any process that stops, prevents or reduces the frequency, rate or extent of transcription.
GO:0016481
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0017148
down regulation of protein biosynthetic process
negative regulation of protein anabolism
negative regulation of protein biosynthesis
negative regulation of protein biosynthetic process
negative regulation of protein formation
negative regulation of protein synthesis
event
IEV:0001839
Negative regulation of translation
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0017148
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0045727
positive regulation of protein anabolism
positive regulation of protein biosynthesis
positive regulation of protein biosynthetic process
positive regulation of protein formation
positive regulation of protein synthesis
up regulation of protein biosynthetic process
event
IEV:0001840
Positive regulation of translation
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0045727
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0006417
regulation of protein anabolism
regulation of protein biosynthesis
regulation of protein formation
regulation of protein synthesis
event
IEV:0001841
Regulation of translation
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
GO:0006417
The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.
GO:0023033
event
IEV:0001842
Signaling pathway
The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.
GO:0023033
IMR:0000095
event
IEV:0001843
Negative regulation of (Phosphorylation of cytokine receptor) in JAK STAT pathway
IMR:0000213
PubMed:14607831
event
IEV:0001844
Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway
IMR:0000374
event
IEV:0001845
Negative regulation of (Phosphorylation of STAT) in JAK STAT pathway
IMR:0000371
IMR:0100315
event
IEV:0001846
Negative regulation of (nuclear import of R-Smad:Smad4) in TGF beta super family signaling pathway
IMR:0000371
IMR:0100315
event
IEV:0001847
Positive regulation of (transcription by R-Smad:Smad4 ) in TGF beta super family signaling pathway by (Smad4 sumoylation by PIAS1)
event
IEV:0001848
Negative regulation of (phosphorylation of AKT(PKB)) in AKT(PKB) activation signaling
event
IEV:0001849
Negative regulation of (dephosphorylation of AKT(PKB)) in negative regulation of AKT(PKB)-Bad signaling
true
event
IEV:0001850
Regulation of AKT(PKB)-Bad signaling
event
IEV:0001851
Negative regulation of AKT(PKB)-Bad signaling
event
IEV:0001852
Positive regulation of AKT(PKB)-Bad signaling
event
IEV:0001853
Positive regulation of (phosphorylation of Bad) in AKT(PKB)-Bad signaling
true
IMR:0000041
IMR:0000712
event
IEV:0001854
Binding of TGF beta and TGF-beta receptor II in extracellular
IMR:0000041
IMR:0000710
IMR:0000712
event
IEV:0001855
Binding of TGF beta:TGF beta receptor II and TGF beta receptor I in plasma membrane
IMR:0001424
IMR:0001425
event
IEV:0001856
Binding of BMP2 and BMP receptor I in extracellular
event
IEV:0001857
Negative regulation of (phosphorylation of Bad) in AKT(PKB)-Bad signaling
true
IMR:0001350
event
IEV:0001858
Negative regulation of (phosphorylation of PIP2) in AKT(PKB) activation signaling
event
IEV:0001859
Regulation of (negative regulation of AKT(PKB) activation signaling)
event
IEV:0001860
Negative regulation of (negative regulation of AKT(PKB) activation signaling)
event
IEV:0001861
Negative regulation of (dephosphorylation of AKT(PKB) in negative regulation of AKT(PKB) activation signaling)
event
IEV:0001862
Positive regulation of (phosphorylation of AKT(PKB) in AKT(PKB) activation signaling
event
IEV:0001863
Protein nuclear import/export signaling
event
IEV:0001864
HDAC nuclear import/export signaling
event
IEV:0001865
HDAC nuclear import signaling
event
IEV:0001866
HDAC nuclear export signaling
event
IEV:0001867
Regulation of HDAC nuclear export signaling
event
IEV:0001868
Positive regulation of HDAC nuclear export signaling
event
IEV:0001869
Negative regulation of HDAC nuclear export signaling
event
IEV:0001870
Regulation of HDAC nuclear import signaling
event
IEV:0001871
Negative regulation of HDAC nuclear import signaling
event
IEV:0001872
Positive regulation of HDAC nuclear import signaling
IMR:0001171
IMR:0001173
UniProt:Q02078
event
IEV:0001873
Dissociation of HDAC5/7 and MEF2 in inner space of nucleus
UniProt:Q02078
event
IEV:0001874
Transcription by MEF2 in nucleus
event
IEV:0001875
Negative regulation of transcription in endothelin signaling by histone acetylation
IMR:0001171
IMR:0001173
PubMed:11509672
PubMed:11585834
event
IEV:0001876
Deacetylation of histone by HDAC5/7 in nucleus
IMR:0001171
IMR:0100202
PubMed:11509672
event
IEV:0001877
Binding of HDAC5 and importin alpha in cytosol
KEGG:map00534
event
IEV:0001878
Heparan sulfate biosynthesis
IMR:0001171
PubMed:11509672
event
IEV:0001879
Deacetylation of histone by HDAC5 in nucleus
IMR:0001173
PubMed:11585834
event
IEV:0001880
Deacetylation of histone by HDAC7 in nucleus
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
GO:0000162
KEGG:map00400
tryptophan anabolism
tryptophan biosynthetic process
tryptophan formation
tryptophan synthesis
event
IEV:0001881
Tryptophan biosynthesis
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
GO:0000162
IMR:0001171
PubMed:11509672
event
IEV:0001882
Nuclear import of HDAC5
IMR:0001173
PubMed:11585834
event
IEV:0001883
Nuclear import of HDAC7
IMR:0001173
UniProt:Q02078
event
IEV:0001884
Dissociation of HDAC7 and MEF2 in inner space of nucleus
IMR:0001171
UniProt:Q02078
event
IEV:0001885
Dissociation of HDAC5 and MEF2 in inner space of nucleus
IEV:0000220
IEV:0000922
Unknown interaction
Unknown process
event
IEV:0001886
Molecular interaction
IMR:0000212
IMR:0100352
event
IEV:0001887
Phosphorylation of Fyn by Csk and inactive conformational change in cytosol
IMR:0100352
event
IEV:0001888
Negative regulation of (Autophosphorylation of Fyn) in Fyn activation signaling
IMR:0100352
event
IEV:0001889
Negative regulation of (dephosphorylation of Fyn) in Fyn activation signaling
event
IEV:0001890
Lck inactivation signaling (through Csk)
event
IEV:0001891
Fyn inactivation signaling (through Csk)
IMR:0000273
event
IEV:0001892
Src inactivation signaling (through PTP)
event
IEV:0001893
Src inactivation signaling (through non-receptor kinase)
IMR:0000273
event
IEV:0001894
Negative regulation of (phosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
IMR:0000212
IMR:0100353
event
IEV:0001895
Phosphorylation of Lck by Csk and inactive conformational change in cytosol
IMR:0000273
event
IEV:0001896
Negative regulation of Lck activation signaling (autophosphorylation and PTP)
IMR:0000245
IMR:0001358
PubMed:7499357
event
IEV:0001897
Binding of phosphatidylserine and PKC and active conformational change of PKC in plasma membrane
IMR:0001358
IMR:0100486
PubMed:7499357
event
IEV:0001898
Binding of phosphatidylserine and cPKC and active conformational change of cPKC in plasma membrane
IMR:0001358
IMR:0100484
PubMed:7499357
event
IEV:0001899
Binding of phosphatidylserine and PKC theta and active conformational change of PKC theta in plasma membrane
event
IEV:0001900
Regulation of cPKC activation signaling
event
IEV:0001901
Negative regulation of cPKC activation signaling
event
IEV:0001902
Positive regulation of cPKC activation signaling
IMR:0100031
event
IEV:0001903
Negative regulation of (binding of calcium ion and cPKC) in cPKC activation signaling
event
IEV:0001904
Negative regulation of (binding of DAG and cPKC) in cPKC activation signaling
IMR:0001358
event
IEV:0001905
Negative regulation of (binding of phosphatidylserine and cPKC) in cPKC activation signaling
IMR:0100031
IMR:0100486
event
IEV:0001906
Dissociation of calcium ion and cPKC
IMR:0100027
IMR:0100486
event
IEV:0001907
Dissociation of DAG and cPKC
IMR:0001358
IMR:0100486
PubMed:7499357
event
IEV:0001908
Dissociation of phosphatidylserine and cPKC in plasma membrane
event
IEV:0001909
Regulation of PKC activation signaling
event
IEV:0001910
Positive regulation of PKC activation signaling
event
IEV:0001911
Negative regulation of PKC activation signaling
event
IEV:0001912
Regulation of PKC theta activation signaling
event
IEV:0001913
Negative regulation of PKC theta activation signaling
event
IEV:0001914
Positive regulation of PKC theta activation signaling
event
IEV:0001915
Negative regulation of (binding of DAG and PKC theta) in PKC theta activation signaling
IMR:0001358
event
IEV:0001916
Negative regulation of (binding of phosphatidylserine and PKC theta) in PKC theta activation signaling
IMR:0100027
IMR:0100484
event
IEV:0001917
Dissociation of DAG and PKC theta
IMR:0001358
IMR:0100484
event
IEV:0001918
Dissociation of phosphatidylserine and PKC theta in plasma membrane
IMR:0100031
event
IEV:0001919
Negative regulation of (binding of calcium ion and PKC) in PKC activation signaling
event
IEV:0001920
Negative regulation of (binding of DAG and PKC) in PKC activation signaling
IMR:0001358
event
IEV:0001921
Negative regulation of (binding of phosphatidylserine and PKC) in PKC activation signaling
IMR:0000245
IMR:0100031
event
IEV:0001922
Dissociation of calcium ion and PKC
IMR:0000245
IMR:0100027
event
IEV:0001923
Dissociation of DAG and PKC
IMR:0000245
IMR:0001358
PubMed:7499357
event
IEV:0001924
Dissociation of phosphatidylserine and PKC in plasma membrane
event
IEV:0001925
Regulation of PKA activation signaling
event
IEV:0001926
Negative regulation of PKA activation signaling
event
IEV:0001927
Positive regulation of PKA activation signaling
event
IEV:0001928
Negative feedback regulation of p53 degradation signaling
true
IMR:0100660
IMR:0701007
PubMed:15021897
event
IEV:0001929
Binding of Mdm2 and p14ARF in inner space of nucleus
IMR:0100660
UniProt:O15151
event
IEV:0001930
Ubiquitination of Mdm4 by Mdm2 in nucleus
UniProt:O15151
event
IEV:0001931
Proteasome degradation of Mdm4 in cytosol
IMR:0000329
IMR:0100659
PubMed:15021897
event
IEV:0001932
Ubiquitination of p53 by ubiquitin ligase in nucleus
IMR:0100660
PubMed:12860999
UniProt:O15151
event
IEV:0001933
Binding of Mdm2 and Mdm4 in inner space of nucleus
IMR:0000447
IMR:0100660
PubMed:12860999
PubMed:15021897
event
IEV:0001934
Binding of Mdm2 and ARF in inner space of nucleus
PubMed:12860999
UniProt:O15151
event
IEV:0001935
Nuclear import of Mdm4
IMR:0000003
IMR:0000981
PubMed:15166250
PubMed:15473860
PubMed:8985181
event
IEV:0001936
Palmitoylation of Wnt by Porcupine in ER
event
IEV:0001937
Palmitoylation in ER
IMR:0000003
PubMed:15473860
event
IEV:0001938
Translocation of Wnt from ER to extracellular space
event
IEV:0001939
Translocation from ER to extracellular space
IMR:0002951
PubMed:12581524
PubMed:15473860
event
IEV:0001940
Translocation of Arrow/LRP5/6 from ER to plasma membrane
event
IEV:0001941
Translocation from ER to plasma membrane
IEV:0002197
Translocation from cytosol to plasma membrane
event
IEV:0001942
Translocation from cytosol to plasma membrane
IEV:0000275
Translocation from the ER to the cytosol
event
IEV:0001943
Translocation from ER to cytosol
IMR:0000970
event
IEV:0001944
Translocation of LRP6 from ER to plasma membrane
IMR:0002951
event
IEV:0001945
Translocation of Arrow/LRP5/6 from ER to cytosol
IMR:0002951
event
IEV:0001946
Translocation of Arrow/LRP5/6 from cytosol to plasma membrane
IMR:0000970
event
IEV:0001947
Translocation of LRP6 from cytosol to plasma membrane
IMR:0000970
event
IEV:0001948
Translocation of LRP6 from ER to cytosol
IMR:0000003
IMR:0000055
IMR:0002951
PubMed:11029006
PubMed:11029007
PubMed:12205098
PubMed:15473860
PubMed:8717036
event
IEV:0001949
Binding of Wnt, Frizzled and Arrow/LRP5/6 in extracellular
IMR:0002951
PubMed:11029007
PubMed:14731402
PubMed:15473860
event
IEV:0001950
Phosphorylation of Arrow/LRP5/6 in cytosol
IMR:0000432
IMR:0002951
PubMed:11336703
PubMed:1236921
PubMed:14731402
PubMed:15473860
event
IEV:0001951
Binding of Arrow/LRP5/6 and Axin in cytosol
IMR:0000432
IMR:0100755
PubMed:10688669
PubMed:15473860
event
IEV:0001952
Binding of Dsh and Axin in cytosol
IMR:0000257
IMR:0001247
IMR:0100755
PubMed:10428961
PubMed:10684251
PubMed:10882137
PubMed:15473860
PubMed:9635432
event
IEV:0001953
Binding of Dsh and GBP/Frat and GSK-3 in cytosol
IMR:0000177
IMR:0000205
IMR:0000257
IMR:0000280
IMR:0000432
event
IEV:0001954
Complex formation of Axin, APC, GSK-3, Beta catenin and PP2A in cytosol
IMR:0000177
IMR:0000280
event
IEV:0001955
Dephosphorylation of beta-catenin by PP2A in cytosol
IMR:0000177
IMR:0000418
IMR:0001178
IMR:0001179
event
IEV:0001956
Binding of Pygopus, Legless and beta-catenin:TCF complex in inner space of nucleus
IMR:0000177
IMR:0000426
event
IEV:0001957
Binding of CBP and beta-catenin in inner space of nucleus
IMR:0000177
IMR:0000418
IMR:0001951
event
IEV:0001958
Binding of Brg1 and beta-catenin:TCF complex in inner space of nucleus
IMR:0000003
IMR:0000989
event
IEV:0001959
Binding of Wnt and WIF in extracellular
IMR:0000003
IMR:0000983
event
IEV:0001960
Binding of Wnt and SFRP in extracellular
IMR:0000991
IMR:0000996
IMR:0002951
event
IEV:0001961
Binding of Dkk, Arrow/LRP5/6 and Kremen in extracellular
IMR:0000970
IMR:0000992
IMR:0000998
event
IEV:0001962
Binding of Dkk1, LRP6 and Kremen2 in extracellular
IMR:0000993
IMR:0000998
IMR:0002951
event
IEV:0001963
Binding of Dkk2, Arrow/LRP5/6 and Kremen2 in extracellular
IMR:0001162
IMR:0002951
event
IEV:0001964
Binding of Wise and Arrow/LRP5/6 in extracellular
IMR:0002951
event
IEV:0001965
Internalization of Arrow/LRP5/6
IMR:0000970
event
IEV:0001966
Internalization of LRP6
IMR:0000177
IMR:0000205
IMR:0000257
IMR:0000432
event
IEV:0001967
Complex formation of Axin, APC, GSK-3 and Beta catenin in cytosol
IMR:0000177
IMR:0000205
IMR:0000257
IMR:0000432
IMR:0100810
event
IEV:0001968
Complex formation of Axin, APC, GSK-3, CK1alpha and beta catenin in cytosol
IMR:0000177
IMR:0100810
event
IEV:0001969
Phosphorylation of beta-catenin by CK1alpha in cytosol
IMR:0000177
IMR:0000257
event
IEV:0001970
Phosphorylation of beta-catenin by GSK-3 in cytosol
IEV:0001740
IMR:0000177
IMR:0100470
Ubiquitination of beta catenin
event
IEV:0001971
Ubiquitination of beta-catenin by SCF ubiquitin ligase complex in cytosol
IMR:0000177
IMR:0001159
event
IEV:0001972
Binding of Chibby and beta-catenin in inner space of nucleus
IMR:0000177
IMR:0001161
event
IEV:0001973
Binding of ICAT and beta-catenin in inner space of nucleus
IMR:0000418
IMR:0001164
event
IEV:0001974
Phosphorylation of TCF by NLK in inner space of nucleus
IMR:0000418
IMR:0100748
event
IEV:0001975
Binding of Groucho and TCF in inner space of nucleus
IMR:0000418
event
IEV:0001976
Nuclear export of TCF
IMR:0000265
IMR:0000351
PubMed:11282018
event
IEV:0001977
Binding of IRS and PI3K in cytosol
event
IEV:0001978
PI3K activation signaling (through Estrogen receptor)
event
IEV:0001979
PI3K activation signaling (through IRS)
IMR:0000890
IMR:0100427
PubMed:12620219
event
IEV:0001980
Dissociation of IRAK1_p and TRAF6 in cytosol
IMR:0000316
IMR:0001357
IMR:0100018
PubMed:14734786
event
IEV:0001981
Binding of G alpha-GDP and G beta:G gamma in cytosol
IMR:0001357
IMR:0100018
IMR:0100366
PubMed:14734786
event
IEV:0001982
Binding of G alpha s-GDP and G beta:G gamma in cytosol
IMR:0000137
IMR:0000316
PubMed:14734786
event
IEV:0001983
Binding of GPCR and G alpha in cytosol
IMR:0000137
IMR:0100366
PubMed:14734786
event
IEV:0001984
Binding of GPCR and G alpha s in cytosol
IMR:0100018
IMR:0200776
PubMed:14734786
event
IEV:0001985
Free Gbetagamma can directly bind the regulatory p101 of PI3K gamma, leading to PI3K activation.
Binding of G beta:G gamma and PI3K gamma
event
IEV:0001987
PI3K gamma activation singlaing
A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
GO:0019933
3',5' cAMP-mediated signaling
3',5'-cAMP-mediated signaling
adenosine 3',5'-cyclophosphate-mediated signaling
cAMP signaling
cAMP-mediated signaling
cyclic AMP-mediated signaling
event
IEV:0001988
cAMP mediated signaling
A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
GO:0019933
event
IEV:0001989
Epac:Rap guanine nucleotide exchange factor by cAMP.
Epac activation signaling
event
IEV:0001990
Cyclic nucleotide-gated cannel activation signaling
IMR:0000265
IMR:0100321
event
IEV:0001991
Phosphorylation of PI3K by JAK3_p in cytosol
IMR:0001354
IMR:0100366
event
IEV:0001992
Binding of G alpha s-GTP and effector in cytosol
IMR:0000211
IMR:0001354
IMR:0100366
PubMed:14734786
event
IEV:0001993
Binding of G alpha s-GTP and Src family in cytosol
PubMed:14734786
event
IEV:0001994
Binding of G beta gamma and GRK2/3
true
event
IEV:0001995
Binding of G beta gamma and calcium ion channel
true
PubMed:14734786
event
IEV:0001996
Binding of G beta gamma and sodium ion channel
true
IMR:0000319
IMR:0001354
event
IEV:0001997
Binding of G alpha i-GTP and effector in cytosol
IMR:0000320
IMR:0001354
event
IEV:0001998
Binding of G alpha o-GTP and effector in cytosol
PubMed:14734786
event
IEV:0001999
Binding of G alpha i-GTP and PLC beta
true
IMR:0000286
IMR:0001354
IMR:0100375
PubMed:14734786
event
IEV:0002000
Binding of G alpha 11-GTP and PLC beta in cytosol
IMR:0000324
IMR:0001354
IMR:0001954
PubMed:14734786
event
IEV:0002001
Binding of G alpha 12/13-GTP and RhoGEF in cytosol
IMR:0000313
event
IEV:0002002
Negative regulation of (Binding of G alpha s-GTP and adenylate cyclase)
G alpha s activation signaling
event
IEV:0002003
G alpha s GDP-GTP exchange signaling
event
IEV:0002004
Negative regulation of (G alpha s GDP-GTP exchange signaling)
event
IEV:0002005
Regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
event
IEV:0002006
Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
event
IEV:0002007
Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
event
IEV:0002008
Regulation of G alpha s-GTP hydrolysis signaling
event
IEV:0002009
Negative regulation of G alpha s-GTP hydrolysis signaling
event
IEV:0002010
Positive regulation of G alpha s-GTP hydrolysis signaling
IMR:0000431
event
IEV:0002011
Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through G alpha s GDP-GTP exchange signaling)
event
IEV:0002012
G alpha GDP-GTP exchange signaling
IMR:0000321
IMR:0001354
event
IEV:0002013
Binding of G alpha t-GTP and effector in cytosol
IMR:0001354
IMR:0100375
event
IEV:0002014
Binding of G alpha 11-GTP and effector in cytosol
IMR:0000286
IMR:0000324
IMR:0001354
event
IEV:0002015
Binding of G alpha 12/13-GTP and PLC beta in cytosol
IMR:0001354
IMR:0100378
event
IEV:0002016
Binding of G alpha q-GTP and effector in cytosol
event
IEV:0002017
G alpha i GDP-GTP exchange signaling
IMR:0000137
IMR:0000319
PubMed:14734786
event
IEV:0002018
Binding of GPCR and G alpha i in cytosol
IMR:0000319
IMR:0001357
IMR:0100018
PubMed:14734786
event
IEV:0002019
Binding of G alpha i-GDP and G beta:G gamma in cytosol
IMR:0000313
event
IEV:0002020
Negative regulation of (Binding of G alpha i-GTP and adenylate cyclase)
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
GO:0007190
PubMed:14734786
adenylate cyclase activation
event
IEV:0002021
Adenylate cyclase activation signaling
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
GO:0007190
PubMed:14734786
event
IEV:0002022
Adenylate cyclase inactivation signaling
event
IEV:0002023
Positive regulation of G alpha i-GTP hydrolysis signaling
event
IEV:0002024
Regulation of G alpha i-GTP hydrolysis signaling
event
IEV:0002025
Positive regulation of heteromeric GPCR signaling pathway (through G alpha i and pertussis toxin)
event
IEV:0002026
Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)
event
IEV:0002027
Negative regulation of (Binding of GPCR and G alpha i)
true
event
IEV:0002028
cAMP concentration elevation
event
IEV:0002029
cAMP concentration decline
IMR:0000137
event
IEV:0002030
Negative regulation of (Binding of GPCR ligand and GPCR)
event
IEV:0002031
G alpha q GDP-GTP exchange signaling
IMR:0001357
IMR:0100018
IMR:0100378
PubMed:14734786
event
IEV:0002032
Binding of G alpha q-GDP and G beta:G gamma in cytosol
event
IEV:0002033
Negative regulation of G alpha i-GTP hydrolysis signaling
IMR:0000431
event
IEV:0002034
Negative regulation of (Hydrolysis of GTP by G alpha i-GTP and RGS)
event
IEV:0002035
Regulation of G alpha q-GTP hydrolysis signaling
event
IEV:0002036
Negative regulation of G alpha q-GTP hydrolysis signaling
IMR:0000431
IMR:0100378
event
IEV:0002037
Negative regulation of (Hydrolysis of GTP by G alpha q-GTP and RGS)
event
IEV:0002038
Positive regulation of G alpha q-GTP hydrolysis signaling
event
IEV:0002039
Regulation of G alpha t-GTP hydrolysis signaling
event
IEV:0002040
Positive regulation of G alpha t-GTP hydrolysis signaling
event
IEV:0002041
Negative regulation of G alpha t-GTP hydrolysis signaling
IMR:0000431
event
IEV:0002042
Negative regulation of (Hydrolysis of GTP by G alpha t-GTP and RGS)
event
IEV:0002043
G alpha t GDP-GTP exchange signaling
event
IEV:0002044
Regulation of G alpha GDP-GTP exchange signaling
event
IEV:0002045
Regulation of G alpha s GDP-GTP exchange signaling
event
IEV:0002046
Negative regulation of G alpha GDP-GTP exchange signaling
event
IEV:0002047
Positive regulation of G alpha GDP-GTP exchange signaling
event
IEV:0002048
Regulation of G alpha i GDP-GTP exchange signaling
event
IEV:0002049
Regulation of G alpha q GDP-GTP exchange signaling
event
IEV:0002050
Regulation of G alpha t GDP-GTP exchange signaling
event
IEV:0002051
Negative regulation of G alpha i GDP-GTP exchange signaling
event
IEV:0002052
Negative regulation of G alpha q GDP-GTP exchange signaling
event
IEV:0002053
Negative regulation of G alpha s GDP-GTP exchange signaling
event
IEV:0002054
Negative regulation of G alpha t GDP-GTP exchange signaling
event
IEV:0002055
Positive regulation of G alpha i GDP-GTP exchange signaling
event
IEV:0002056
Positive regulation of G alpha q GDP-GTP exchange signaling
event
IEV:0002057
Positive regulation of G alpha s GDP-GTP exchange signaling
event
IEV:0002058
Positive regulation of G alpha t GDP-GTP exchange signaling
IMR:0001357
event
IEV:0002059
Negative regulation of (GDP-GTP exchange of G alpha)
IMR:0001357
event
IEV:0002060
Negative regulation of (GDP-GTP exchange of G alpha i)
IMR:0001357
IMR:0100378
event
IEV:0002061
Negative regulation of (GDP-GTP exchange of G alpha q)
IMR:0001357
event
IEV:0002062
Negative regulation of (GDP-GTP exchange of G alpha s)
IMR:0001357
event
IEV:0002063
Negative regulation of (GDP-GTP exchange of G alpha t)
IMR:0000137
IMR:0100378
PubMed:14734786
event
IEV:0002064
Binding of GPCR and G alpha q in cytosol
IMR:0000137
IMR:0000321
PubMed:14734786
event
IEV:0002065
Binding of GPCR and G alpha t in cytosol
IMR:0000431
event
IEV:0002066
Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through Adenylate cyclase activation signaling)
IMR:0000224
IMR:0000259
event
IEV:0002067
Phosphorylation of MAPK by MEK in cytosol
IMR:0000675
IMR:0001504
PubMed:11752597
PubMed:9247123
event
IEV:0002068
Activation of B-Raf by Rap1 in cytosol
IMR:0000675
IMR:0001504
PubMed:11752597
PubMed:9560161
event
IEV:0002069
Binding of Rap1 and B-Raf in cytosol
PubMed:9560161
event
IEV:0002070
Binding of Rap1 and Crk
true
IMR:0001354
IMR:0001357
IMR:0001504
IMR:0001968
PubMed:11752597
event
IEV:0002071
GDP-GTP exchange of Rap1 by Epac1 in cytosol
event
IEV:0002072
Raf activation signaling
IMR:0001967
IMR:0100024
PubMed:9853756
event
IEV:0002073
Activation of Epac by cAMP in cytosol
IMR:0000316
IMR:0001357
event
IEV:0002074
Binding of G alpha-GDP and effector in cytosol
IMR:0000320
IMR:0001357
PubMed:10419452
UniProt:P47736
event
IEV:0002075
Binding of G alpha o -GDP and Rap1GAP1 in cytosol
IMR:0000319
IMR:0001354
PubMed:10476970
UniProt:Q684P5
event
IEV:0002076
Binding of G alpha i-GTP and Rap1GAP2 in cytosol
IMR:0000322
IMR:0001354
event
IEV:0002077
Binding of G alpha z-GTP and effector in cytosol
IMR:0000322
IMR:0001354
PubMed:10593970
UniProt:P47736
event
IEV:0002078
Binding of G alpha z-GTP and Rap1GAP1 in cytosol
event
IEV:0002079
Rap1 activation signaling
PubMed:11752597
event
IEV:0002080
Rap1 activation signaling (through cAMP and Epac)
PubMed:11804588
event
IEV:0002081
Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)
IMR:0000249
IMR:0100575
PubMed:11804588
event
IEV:0002082
Phosphorylation of Src by PKA in cytosol
IMR:0000356
IMR:0100575
PubMed:11804588
PubMed:15345216
PubMed:20584982
event
IEV:0002083
Phosphorylation of Cbl by Src in cytosol
event
IEV:0002084
B-Raf activation signaling
IMR:0001357
IMR:0001504
IMR:0001968
event
IEV:0002085
Negative regulation of (GDP-GTP exchange of Rap1 by Epac1)
IMR:0000229
IMR:0000681
event
IEV:0002086
Phosphorylation of MAPKKK by non-receptor serine/threonine kinase in cytosol
IMR:0000231
IMR:0000245
PubMed:8321321
event
IEV:0002087
Phosphorylation of Raf by PKC in cytosol
IMR:0000261
IMR:0000675
PubMed:11752597
event
IEV:0002088
Phosphorylation of MEK1/2(MKK1/2) by B-Raf in cytosol
event
IEV:0002089
Rap1 inactivation signaling
IMR:0001354
event
IEV:0002090
Hydrolysis of GTP by RapGAP in cytosol
IMR:0001354
PubMed:11752597
UniProt:P47736
event
IEV:0002091
Hydrolysis of GTP by Rap1GAP1 in cytosol
IMR:0001354
PubMed:11752597
UniProt:Q684P5
event
IEV:0002092
Hydrolysis of GTP by Rap1GAP2 in cytosol
IMR:0000335
IMR:0000356
PubMed:11804588
event
IEV:0002093
Binding of Crk and Cbl in cytosol
true
The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK).
GO:0007257
IMR:0000225
IMR:0000259
activation of JNK activity
event
IEV:0002095
Phosphorylation of JNK by MKK_p in cytosol
The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK).
GO:0007257
IMR:0000095
IMR:0000374
PubMed:12039028
event
IEV:0002096
Dissociation of cytokine receptor and STAT in cytosol
IGS:0000028
IMR:0000414
event
IEV:0002097
Binding of AP-1 and responsive element in inner space of nucleus
IGS:0000028
IMR:0000368
Binding of transcription factor and responsive element in inner space of nucleus
event
IEV:0002098
Binding of transcription factor and responsive element in inner space of nucleus
IMR:0000006
IMR:0000414
event
IEV:0002099
Transcription of cytokine by AP-1 in nucleus
IGS:0000018
IMR:0000374
PubMed:12039028
event
IEV:0002100
Binding of STAT dimer and GAS in inner space of nucleus
IEV:0000144
IEV:0002234
IMR:0000374
IMR:0000460
PubMed:14607831
Gene expression of CIS by STAT dimer
Gene expression of CIS family
event
IEV:0002101
Gene expression of SOCS by STAT dimer
IMR:0000374
PubMed:14607831
event
IEV:0002102
Gene expression by STAT dimer
IEV:0002237
IMR:0000374
IMR:0000460
PubMed:14607831
Transcription of CIS by STAT dimer in nucleus
event
IEV:0002103
Transcription of SOCS by STAT dimer in nucleus
IEV:0002236
IMR:0000460
PubMed:14607831
Translation of CIS in cytosol
event
IEV:0002104
Translation of SOCS in cytosol
IEV:0002235
IMR:0000460
PubMed:14607831
Nuclear export of mRNA (CIS)
event
IEV:0002105
Nuclear export of mRNA (SOCS)
IMR:0000226
IMR:0000259
event
IEV:0002106
Phosphorylation of p38 by MKK_p in cytosol
IMR:0000135
IMR:0000376
PubMed:12040185
event
IEV:0002107
Binding of IFN alpha receptor and STAT2 in cytosol
IMR:0000135
IMR:0000375
PubMed:15561601
event
IEV:0002108
Binding of IFN alpha receptor and STAT1 in cytosol
IMR:0000135
IMR:0000377
PubMed:15561601
event
IEV:0002109
Binding of IFN alpha receptor and STAT3 in cytosol
IMR:0000136
IMR:0000375
PubMed:12040185
event
IEV:0002110
Binding of IFN gamma receptor and STAT1 in cytosol
IMR:0000104
IMR:0000377
PubMed:12040185
event
IEV:0002111
Binding of IL-6 receptor and STAT3 in cytosol
IMR:0000377
IMR:0000608
PubMed:10433356
PubMed:12626585
event
IEV:0002112
Binding of IL-10 receptor and STAT3 in cytosol
IMR:0000097
IMR:0100733
PubMed:10920190
PubMed:11160217
event
IEV:0002113
Binding of IL-2 receptor and STAT5 in cytosol
IMR:0000378
IMR:0000602
PubMed:10415122
PubMed:12805384
event
IEV:0002114
Binding of IL-12 receptor and STAT4 in cytosol
IMR:0001422
PubMed:12040185
Nuclear import of STAT1:STAT2:IRF9
event
IEV:0002115
Nuclear import of ISGF3
IMR:0000375
PubMed:12040185
event
IEV:0002116
Nuclear import of STAT1 homodimer
IMR:0000377
PubMed:10857556
PubMed:12040185
event
IEV:0002117
Nuclear import of STAT3 homodimer
IMR:0000375
IMR:0000377
PubMed:15561601
event
IEV:0002118
Nuclear import of STAT1:STAT3 heterodimer
IMR:0100733
PubMed:11160217
PubMed:15561601
event
IEV:0002119
Nuclear import of STAT5 homodimer
IMR:0000378
PubMed:12805384
PubMed:15004198
event
IEV:0002120
Nuclear import of STAT4 homodimer
IMR:0000375
IMR:0000376
PubMed:11932384
event
IEV:0002121
Dimerization of STAT1 and STAT2 in cytosol
IMR:0000375
PubMed:12040185
PubMed:15561601
event
IEV:0002122
Dimerization of STAT1 in cytosol
IMR:0000377
PubMed:10433356
PubMed:10857556
PubMed:12040185
event
IEV:0002123
Dimerization of STAT3 in cytosol
IMR:0000375
IMR:0000377
PubMed:15561601
event
IEV:0002124
Dimerization of STAT1 and STAT3 in cytosol
IMR:0100733
PubMed:11160217
event
IEV:0002125
Dimerization of STAT5 in cytosol
IMR:0000378
PubMed:15004198
event
IEV:0002126
Dimerization of STAT4 in cytosol
IMR:0000376
IMR:0100319
IMR:0100322
PubMed:12040185
event
IEV:0002127
Phosphorylation of STAT2 by JAK1_p and TYK2_p in cytosol
IMR:0000375
IMR:0100319
IMR:0100322
PubMed:12040185
PubMed:15561601
event
IEV:0002128
Phosphorylation of STAT1 by JAK1_p and TYK2_p in cytosol
IMR:0000377
IMR:0100319
IMR:0100322
PubMed:10433356
PubMed:12626585
PubMed:15561601
event
IEV:0002129
Phosphorylation of STAT3 by JAK1_p and TYK2_p in cytosol
IMR:0000377
IMR:0100319
IMR:0100320
PubMed:10857556
PubMed:12040185
PubMed:15504351
event
IEV:0002130
Phosphorylation of STAT3 by JAK1_p and JAK2_p in cytosol
IMR:0100319
IMR:0100321
IMR:0100733
PubMed:111278301
event
IEV:0002131
Phosphorylation of STAT5 by JAK1_p and JAK3_p in cytosol
IMR:0000378
IMR:0100320
IMR:0100322
PubMed:10415122
PubMed:12805384
event
IEV:0002132
Phosphorylation of STAT4 by JAK2_p and TYK2_p in cytosol
IGS:0000018
IMR:0000375
PubMed:12040185
Binding of STAT1 homodimer and GAS element
event
IEV:0002133
Binding of GAF and GAS element in inner space of nucleus
IGS:0000018
IMR:0000377
PubMed:10857556
PubMed:12040185
event
IEV:0002134
Binding of STAT3 homodimer and GAS element in inner space of nucleus
IGS:0000019
IMR:0000377
PubMed:10857556
PubMed:12040185
event
IEV:0002135
Binding of STAT3 homodimer and SIE element in inner space of nucleus
IGS:0000028
IMR:0000375
IMR:0000377
PubMed:15561601
event
IEV:0002136
Binding of STAT1:STAT3 heterodimer and responsive element in inner space of nucleus
IGS:0000018
IMR:0100733
PubMed:15561601
event
IEV:0002137
Binding of STAT5 homodimer and GAS element in inner space of nucleus
IGS:0000021
IMR:0001422
PubMed:12040185
Binding of STAT1:STAT2:IRF9 and ISRE
event
IEV:0002138
Binding of ISGF3 and ISRE in inner space of nucleus
IGS:0000018
IMR:0000378
PubMed:15004198
PubMed:9144409
event
IEV:0002139
Binding of STAT4 homodimer and GAS element in inner space of nucleus
IMR:0000135
IMR:0100319
IMR:0100322
PubMed:12040185
PubMed:15561601
PubMed:9287210
event
IEV:0002140
Phosphorylation of IFN alpha receptor by JAK1 and TYK2 in cytosol
IMR:0000136
IMR:0100319
IMR:0100320
PubMed:12040185
event
IEV:0002141
Phosphorylation of IFN gamma receptor by JAK1 and JAK2 in cytosol
IMR:0000104
IMR:0100319
IMR:0100320
PubMed:15504351
event
IEV:0002142
Phosphorylation of IL-6 receptor by JAK1 and JAK2 in cytosol
IMR:0000608
IMR:0100319
IMR:0100322
PubMed:12626585
event
IEV:0002143
Phosphorylation of IL-10 receptor by JAK1 and TYK2 in cytosol
IMR:0000097
IMR:0100319
IMR:0100321
PubMed:10920190
PubMed:11160217
event
IEV:0002144
Phosphorylation of IL-2 receptor by JAK1 and JAK3 in cytosol
IMR:0000602
IMR:0100320
IMR:0100322
PubMed:10415122
PubMed:12805384
event
IEV:0002145
Phosphorylation of IL-12 receptor by JAK2 and TYK2 in cytosol
IMR:0000135
IMR:0100319
IMR:0100322
PubMed:12040185
event
IEV:0002146
Binding of IFN alpha receptor and JAK1 and TYK2 in cytosol
IMR:0000136
IMR:0100319
IMR:0100320
PubMed:12040185
event
IEV:0002147
Binding of IFN gamma receptor and JAK1 and JAK2 in cytosol
IMR:0000104
IMR:0100319
IMR:0100320
PubMed:12040185
event
IEV:0002148
Binding of IL-6 receptor and JAK1 and JAK2 in cytosol
IMR:0000608
IMR:0100319
IMR:0100322
PubMed:12626585
event
IEV:0002149
Binding of IL-10 receptor and JAK1 and TYK2 in cytosol
IMR:0000097
IMR:0100319
IMR:0100321
PubMed:10920190
PubMed:8700888
event
IEV:0002150
Binding of IL-2 receptor and JAK1 and JAK3 in cytosol
IMR:0000602
IMR:0100320
IMR:0100322
PubMed:12805384
event
IEV:0002151
Binding of IL-12 receptor and JAK2 and TYK2 in cytosol
IMR:0000135
IMR:0100386
PubMed:12040185
event
IEV:0002152
Binding of IFN alpha and IFN alpha receptor and conformational change of receptors in plasma membrane
IMR:0000136
IMR:0100390
PubMed:12040185
event
IEV:0002153
Binding of IFN gamma and IFN gamma receptor and conformational change of receptors in plasma membrane
IMR:0000010
IMR:0000104
PubMed:12040185
event
IEV:0002154
Binding of IL-6 and IL-6 receptor and conformational change of receptors in plasma membrane
IMR:0000130
IMR:0000377
PubMed:10857556
event
IEV:0002155
Binding of LIF receptor and STAT3 in cytosol
IMR:0000130
IMR:0100319
IMR:0100320
PubMed:10857556
PubMed:12040185
event
IEV:0002156
Phosphorylation of LIF receptor by JAK1 and JAK2 in cytosol
IMR:0000130
IMR:0100319
IMR:0100320
PubMed:10586060
PubMed:10857556
event
IEV:0002157
Binding of LIF receptor and JAK1 and JAK2 in cytosol
IMR:0100322
PubMed:10433356
PubMed:12040185
PubMed:12626585
PubMed:15561601
PubMed:9287210
event
IEV:0002158
Autophosphorylation of TYK2 in cytosol
The process of introducing a phosphoric group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.
IMR:0100320
PubMed:10857556
PubMed:12040185
PubMed:15561601
PubMed:9287210
PubMed:9351438
event
IEV:0002159
Autophosphorylation of JAK2 in cytosol
The process of introducing a phosphoric group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.
GO:0042977
IMR:0100319
PubMed:10433356
PubMed:10857556
PubMed:10920190
PubMed:12039028
PubMed:12040185
PubMed:15561601
PubMed:9287210
PubMed:9351438
event
IEV:0002160
Autophosphorylation of JAK1 in cytosol
IMR:0100321
PubMed:10920190
PubMed:11160217
PubMed:12039028
PubMed:9287210
event
IEV:0002161
Autophosphorylation of JAK3 in cytosol
IMR:0000135
IMR:0000375
PubMed:15561601
event
IEV:0002162
Dissociation of IFN alpha receptor and STAT1 in cytosol
IMR:0000135
IMR:0000377
PubMed:15561601
event
IEV:0002163
Dissociation of IFN alpha receptor and STAT3 in cytosol
IMR:0000136
IMR:0000375
PubMed:12040185
event
IEV:0002164
Dissociation of IFN gamma receptor and STAT1 in cytosol
IMR:0000104
IMR:0000377
PubMed:15504351
event
IEV:0002165
Dissociation of IL-6 receptor and STAT3 in cytosol
IMR:0000377
IMR:0000608
PubMed:15561601
event
IEV:0002166
Dissociation of IL-10 receptor and STAT3 in cytosol
IMR:0000097
IMR:0100733
PubMed:11160217
PubMed:12039028
event
IEV:0002167
Dissociation of IL-2 receptor and STAT5 in cytosol
IMR:0000378
IMR:0000602
PubMed:12039028
PubMed:12040185
PubMed:15004198
event
IEV:0002168
Dissociation of IL-12 receptor and STAT4 in cytosol
IMR:0000375
IMR:0000376
PubMed:12040185
event
IEV:0002169
Binding of STAT1 and STAT2_p in cytosol
IMR:0000375
IMR:0000376
IMR:0000395
PubMed:11932384
PubMed:12040185
event
IEV:0002170
Binding of STAT1:STAT2 heterodimer and IRF9 in cytosol
IMR:0000019
IMR:0000130
PubMed:10857556
PubMed:12487370
event
IEV:0002171
Binding of LIF and LIF receptor and conformational change of receptors in plasma membrane
IMR:0000702
IMR:0001424
IMR:0001425
event
IEV:0002172
Binding of BMP2 and BMP receptor I/II in extracellular
IMR:0100310
IMR:0100315
event
IEV:0002173
Nuclear import of Smad1:Smad4
IMR:0100310
IMR:0100315
event
IEV:0002174
Complex formation of Smad1 and Smad4 in cytosol
IMR:0000377
IMR:0001405
IMR:0100310
IMR:0100315
UniProt:P14136
event
IEV:0002175
Binding of STAT3:p300:Smad1:Smad4 complex and GFAP promoter in inner space of nucleus
IMR:0000130
IMR:0000377
PubMed:10857556
event
IEV:0002176
Dissociation of LIF receptor and STAT3 in cytosol
IMR:0000702
IMR:0001425
event
IEV:0002177
Phosphorylation of BMPR1 by BMPR2 in cytosol
IMR:0000377
IMR:0001405
IMR:0100310
event
IEV:0002178
Binding of STAT3 and p300 and Smad1 in inner space of nucleus
IMR:0100427
event
IEV:0002179
Translocation of TRAF6 to cytosol
PubMed:11278251
event
IEV:0002180
TGF beta receptor complex degradation signaling
IMR:0100318
IMR:0100513
PubMed:11278251
event
IEV:0002181
Complex formation of Smad7 and smurf1 in cytosol
IMR:0000092
IMR:0100318
IMR:0100513
PubMed:11278251
event
IEV:0002182
Binding of Smad7:smurf1 and TGF beta receptor complex in cytosol
IMR:0000092
IMR:0000310
PubMed:11278251
event
IEV:0002183
Proteasome degradation of TGF beta receptor complex by 26S proteasome in plasma membrane
IMR:0000092
IMR:0100318
IMR:0100513
PubMed:11278251
event
IEV:0002184
Dissociation of Smad7:smurf1 and TGF beta receptor complex_Ub in cytosol
IMR:0000092
IMR:0100513
PubMed:11278251
event
IEV:0002185
Ubiquitination of TGF beta receptor complex by smurf1 in cytosol
IMR:0000371
IMR:0100315
event
IEV:0002186
Negative regulation of (transcription by R-Smad:Smad4) in TGF beta super family signaling pathway
IGS:0000028
IMR:0000371
IMR:0000427
IMR:0001166
IMR:0100315
event
IEV:0002187
Binding of R-Smad:Smad4 complex, Corepressor, HDAC and responsive element in inner space of nucleus
PubMed:11389444
event
IEV:0002188
SnoN degradation signaling
IMR:0002129
IMR:0100311
IMR:0100514
PubMed:11389444
event
IEV:0002189
Binding of Smad2, smurf2 and SnoN
IMR:0000371
IMR:0100315
event
IEV:0002190
Positive regulation of (transcription by R-Smad:Smad4 ) in TGF beta super family signaling pathway
IMR:0002129
IMR:0100514
PubMed:11389444
event
IEV:0002191
Ubiquitination of SnoN by smurf2
IMR:0000310
IMR:0002129
PubMed:11389444
event
IEV:0002192
Proteasome degradation of SnoN_ub by 26S proteasome
IMR:0000224
IMR:0100310
PubMed:11752591
event
IEV:0002193
Phosphorylation of Smad1 by MAPK in cytosol
IMR:0000340
IMR:0000348
PubMed:15220003
event
IEV:0002194
Binding of LAT and Grb2 in cytosol
IMR:0100027
IMR:0100349
PubMed:15221855
event
IEV:0002195
Binding of RasGRP and DAG in cytosol
Regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)
event
IEV:0002196
Regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
true
Negative regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)
event
IEV:0002198
Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
event
IEV:0002199
Raf activation signaling (through RasGRP)
IMR:0000290
IMR:0001354
IMR:0001357
IMR:0100349
PubMed:15221855
event
IEV:0002200
GDP-GTP exchange of Ras by RasGRP in cytosol
Positive regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)
event
IEV:0002201
Positive regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
IMR:0000297
IMR:0100484
PubMed:11094261
event
IEV:0002202
Activation of PKC theta by Rac in cytosol
IMR:0100454
IMR:0100484
PubMed:11094621
event
IEV:0002203
Phosphorylation of MKK4(SEK1) by PKC theta in cytosol
IMR:0000225
IMR:0100454
PubMed:11094261
event
IEV:0002204
Phosphorylation of JNK by MKK4(SEK1)_p in cytosol
IMR:0000414
PubMed:7546397
event
IEV:0002205
Nuclear transport of AP-1
IMR:0000008
IMR:0000414
PubMed:7546397
event
IEV:0002206
Gene expression of IL2 by AP-1
IMR:0000008
event
IEV:0002207
Nuclear export of mRNA (IL2)
IMR:0000008
IMR:0000414
PubMed:7546397
event
IEV:0002208
Transcription of IL2 by AP-1 in nucleus
IMR:0000008
PubMed:7546397
event
IEV:0002209
Translation of IL2 in cytosol
IMR:0000006
event
IEV:0002210
Nuclear export of mRNA (cytokine)
IMR:0000006
event
IEV:0002211
Translation of cytokine in cytosol
event
IEV:0002212
Chilling temperature treatment
event
IEV:0002213
Thermoperiodism
event
IEV:0002214
Cell division within the secondary xylem
event
IEV:0002215
Cell division within the vascular cambium
event
IEV:0002216
Cell wall organization and biosynthesis
The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
GO:0030244
cellulose anabolism
cellulose biosynthetic process
cellulose formation
cellulose synthesis
event
IEV:0002217
Cellulose biosynthesis
The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
GO:0030244
event
IEV:0002218
Hemicellulose biosynthesis
PubMed:15541651
event
IEV:0002219
Cytokine receptor degradation signaling
IMR:0000095
IMR:0100839
PubMed:15541651
event
IEV:0002220
Ubiquitination of cytokine receptor by SOCS3 in cytosol
IMR:0000095
IMR:0100839
PubMed:14607831
PubMed:15541651
event
IEV:0002221
Binding of SOCS3 and cytokine receptor in cytosol
IMR:0000095
IMR:0000310
PubMed:15541651
event
IEV:0002222
Proteasome degradation of cytokine receptor by 26S proteasome in cytosol
event
IEV:0002223
Negative feedback regulation of JAK STAT pathway by (cytokine receptor degradation signaling)
IMR:0000374
IMR:0100839
event
IEV:0002224
Gene expression of SOCS3 by STAT dimer
IMR:0000374
IMR:0100839
PubMed:14607831
event
IEV:0002225
Transcription of SOCS3 by STAT dimer in nucleus
IMR:0100839
PubMed:14607831
event
IEV:0002226
Nuclear export of mRNA (SOCS3)
IMR:0100839
PubMed:14607831
event
IEV:0002227
Translation of SOCS3 in cytosol
event
IEV:0002228
Negative feedback regulation of JAK STAT pathway
event
IEV:0002229
Negative feedback regulation of JAK STAT pathway by (JAK degradation signaling)
event
IEV:0002230
JAK degradation signaling
IMR:0000213
IMR:0100837
event
IEV:0002231
Binding of SOCS1 and JAK in cytosol
IMR:0000213
IMR:0100837
event
IEV:0002232
Ubiquitination of JAK by SOCS1
IMR:0000213
IMR:0000310
event
IEV:0002233
Proteasome degradation of JAK by 26S proteasome
true
true
true
true
IMR:0000374
IMR:0100837
PubMed:14607831
event
IEV:0002238
Gene expression of SOCS1 by STAT dimer
IMR:0100837
PubMed:14607831
event
IEV:0002239
Nuclear export of mRNA (SOCS1)
IMR:0000374
IMR:0100837
PubMed:14607831
event
IEV:0002240
Transcription of SOCS1 by STAT dimer in nucleus
IMR:0100837
PubMed:14607831
event
IEV:0002241
Translation of SOCS1 in cytosol
IMR:0000213
IMR:0000275
PubMed:14607831
event
IEV:0002242
Dephosphorylation of JAK by SHP-1 in cytosol
IMR:0000095
IMR:0000275
event
IEV:0002243
Dephosphorylation of cytokine receptor by SHP-1 in cytosol
IMR:0000275
IMR:0100733
PubMed:10617656
event
IEV:0002244
Dephosphorylation of STAT5 by SHP-1 in cytosol
IMR:0000374
PubMed:10617656
event
IEV:0002245
Negative regulation of (Dimerization of STAT) in JAK STAT pathway
IMR:0000374
IMR:0000460
event
IEV:0002246
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway
IMR:0000223
IMR:0000374
PubMed:9153303
event
IEV:0002247
Phosphorylation of STAT dimer by serine kinase in cytosol and/or nucleus
Regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)
event
IEV:0002248
Regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
Negative regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)
event
IEV:0002249
Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
Positive regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)
event
IEV:0002250
Positive regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
IMR:0000221
IMR:0100353
event
IEV:0002251
Negative regulation of (Phosphorylation of ZAP-70 by Lck_PY)
IMR:0000265
IMR:0001350
event
IEV:0002252
Negative regulation of (Phosphorylation of PIP2 by PI3K)
IMR:0000221
event
IEV:0002253
Negative regulation of (Phosphorylation of LAT by ZAP-70)
IMR:0000221
event
IEV:0002254
Negative regulation of (Phosphorylation of Vav by ZAP-70)
event
IEV:0002255
Negative regulation of (Lck activation signaling)
event
IEV:0002256
Negative regulation of (Fyn activation signaling)
IMR:0000222
event
IEV:0002257
Negative regulation of (Phosphorylation of Vav by Syk)
Rearrangement of the spatial distribution of actin filaments and associated proteins that accompanies progression of the cell cycle.
GO:0030037
PubMed:15313367
event
IEV:0002258
Actin filament reorganization during cell cycle
Rearrangement of the spatial distribution of actin filaments and associated proteins that accompanies progression of the cell cycle.
GO:0030037
PubMed:12773095
event
IEV:0002259
IL6 signaling pathway (JAK1, JAK2, STAT3)
PubMed:15561601
event
IEV:0002260
IFN alpha signaling pathway (JAK1, TYK2, STAT1)
PubMed:15561601
event
IEV:0002261
IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands.
GO:0048861
PubMed:10857556
leukemia inhibitory factor signaling pathway
event
IEV:0002262
LIF signaling pathway
The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands.
GO:0048861
PubMed:12041185
event
IEV:0002263
IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)
PubMed:12040185
event
IEV:0002264
IFN gamma signaling pathway (JAK1, JAK2, STAT1)
PubMed:15561601
event
IEV:0002265
IFN alpha signaling pathway (JAK1, TYK2, STAT3)
PubMed:15733830
event
IEV:0002266
TGF beta super family signaling pathway (through JNK cascade)
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
PubMed:15473860
event
IEV:0002267
Wnt signaling pathway (Xenopus)
true
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
XX:<new dbxref>
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
PubMed:15473860
event
IEV:0002268
Wnt signaling pathway (Mammalia)
true
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
XX:<new dbxref>
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
PubMed:15473860
event
IEV:0002269
Wnt signaling pathway (Drosophila)
true
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
XX:<new dbxref>
OBSOLETE: remap to 'Endoderm induction Wnt signaling pathway' IEV:0003455.
PubMed:12210516
event
IEV:0002270
C. elegans endoderm induction Wnt signaling pathway
true
OBSOLETE: remap to 'Endoderm induction Wnt signaling pathway' IEV:0003455.
XX:<new dbxref>
IMR:0000375
IMR:0100319
IMR:0100320
PubMed:12040185
event
IEV:0002271
Phosphorylation of STAT1 by JAK1_p and JAK2_p in cytosol
IMR:0000177
IMR:0000418
IMR:0100315
PubMed:10693808
PubMed:10890911
event
IEV:0002272
Binding of beta-catenin, TCF and Smad4 in inner space of nucleus
IMR:0000418
IMR:0100748
PubMed:15473860
event
IEV:0002273
Dissociation of Groucho and TCF in inner space of nucleus
IGS:0000028
IMR:0000177
IMR:0000418
IMR:0100315
PubMed:10693808
PubMed:10890911
event
IEV:0002274
Binding of beta-catenin:TCF:Smad4 and responsive element in inner space of nucleus
IMR:0001829
PubMed:10693808
PubMed:10890911
event
IEV:0002275
Transcription of Xtwn gene in nucleus
IMR:0001830
PubMed:15473860
event
IEV:0002276
Transcription of Siamois gene in nucleus
true
IMR:0000003
IMR:0001125
PubMed:15473860
PubMed:2158444
event
IEV:0002278
Binding of Wnt and HSPG in extracellular
IMR:0002958
IMR:0100761
PubMed:10421371
PubMed:10978892
PubMed:15473860
event
IEV:0002279
Binding of wingless and Dally in extracellular
IEV:0002277
IMR:0000177
IMR:0000418
Gene expression by beta-catenin TCF complex
Gene expression in response to beta-catenin TCF complex
event
IEV:0002280
Gene expression by beta-catenin:TCF complex
IEV:0000037
IMR:0000177
IMR:0000418
PubMed:15473860
Transcription in response to beta-catenin TCF complex
Transcription in response to beta-catenin TCF complex (Xenopus laevis)
Transcription by beta-catenin TCF complex (C. elegans)
Transcription by beta-catenin TCF complex (Drosophila)
Transcription by beta-catenin TCF complex (Mammals)
Transcription by beta-catenin TCF complex (Xenopus)
event
IEV:0002282
Transcription by beta-catenin:TCF complex in nucleus
IMR:0000177
IMR:0000418
IMR:0100315
event
IEV:0002283
Gene expression by beta-catenin:TCF complex and Smad4
IMR:0000177
IMR:0000418
IMR:0100315
Transcription by beta-catenin TCF complex and Smad4 (Mammals)
Transcription by beta-catenin TCF complex and Smad4 (Xenopus)
event
IEV:0002284
Transcription by beta-catenin:TCF complex and Smad4 in nucleus
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex and Smad4' IEV:0002284.
event
IEV:0002285
Transcription by beta-catenin TCF complex and Smad4 (Xenopus)
true
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex and Smad4' IEV:0002284.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
event
IEV:0002286
Transcription by beta-catenin TCF complex (Mammals)
true
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
PubMed:15473860
event
IEV:0002287
Transcription by beta-catenin TCF complex (Drosophila)
true
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex and Smad4' IEV:0002284.
event
IEV:0002288
Transcription by beta-catenin TCF complex and Smad4 (Mammals)
true
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex and Smad4' IEV:0002284.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
event
IEV:0002289
Transcription by beta-catenin TCF complex (Xenopus)
true
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
XX:<new dbxref>
Regulation of B cell receptor signaling pathway (through IKK-NF-kappaB cascade)
event
IEV:0002290
Regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
event
IEV:0002291
Negative regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
Positive regulation of B cell receptor signaling pathway (through IKK-NF-kappaB cascade)
event
IEV:0002292
Positive regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
IMR:0000107
IMR:0100319
IMR:0100321
event
IEV:0002293
Binding of IL-4 receptor and JAK1 and JAK3 in cytosol
IMR:0000107
IMR:0100319
IMR:0100321
event
IEV:0002294
Phosphorylation of IL-4 receptor by JAK1 and JAK3 in cytosol
IMR:0000107
IMR:0000381
event
IEV:0002295
Binding of IL-4 receptor and STAT6 in cytosol
IMR:0000381
IMR:0100319
IMR:0100321
event
IEV:0002296
Phosphorylation of STAT6 by JAK1_p and JAK3_p in cytosol
IMR:0000107
IMR:0000381
event
IEV:0002297
Dissociation of IL-4 receptor and STAT6 in cytosol
IMR:0000381
event
IEV:0002298
Dimerization of STAT6 in cytosol
IMR:0000381
event
IEV:0002299
Nuclear import of STAT6 homodimer
IGS:0000029
IMR:0000381
event
IEV:0002300
Binding of STAT6 homodimer and promoter in inner space of nucleus
IMR:0000275
IMR:0000381
event
IEV:0002301
Dephosphorylation of STAT6 by SHP-1 in cytosol
PubMed:12461567
event
IEV:0002302
Syk activation signaling
PubMed:12461567
event
IEV:0002303
Lyn activation signaling
IMR:0000211
IMR:0100541
PubMed:12461567
event
IEV:0002304
Phosphorylation of Ig alpha by Lyn in cytosol
IMR:0000211
IMR:0100542
PubMed:12461567
event
IEV:0002305
Phosphorylation of Ig beta by Lyn in cytosol
IMR:0000222
IMR:0100542
ISBN:081533642X
event
IEV:0002306
Binding of Ig beta and Syk in cytosol
IMR:0000222
IMR:0000353
PubMed:152119998
event
IEV:0002307
Phosphorylation of BLNK by Syk in cytosol
IMR:0000222
IMR:0000733
PubMed:12461567
event
IEV:0002308
Phosphorylation of PLC gamma2 by Syk in cytosol
IMR:0000215
IMR:0000733
PubMed:12461567
event
IEV:0002309
Phosphorylation of PLC gamma2 by Btk in cytosol
IMR:0000215
IMR:0000353
IMR:0000434
IMR:0000733
IMR:0001352
PubMed:12461567
event
IEV:0002310
Binding of BLNK, BTK, PLC gamma2, Vav and PIP3 in cytosol
IMR:0000353
IMR:0000733
PubMed:12461567
event
IEV:0002311
Binding of BLNK and PLC gamma2 in cytosol
IMR:0000733
IMR:0001352
IMR:0002136
PubMed:12461567
event
IEV:0002312
Binding of PLC gamma2, BAM32 and PIP3 in cytosol
IMR:0000215
IMR:0001352
event
IEV:0002313
Binding of Btk and PIP3 in cytosol
IMR:0001352
IMR:0002136
event
IEV:0002314
Binding of BAM32 and PIP3 in cytosol
IMR:0000733
IMR:0001352
event
IEV:0002315
Binding of PLC gamma2 and PIP3 in cytosol
IMR:0000265
IMR:0001964
PubMed:12461567
event
IEV:0002316
Binding of CD19 and PI3K in cytosol
IMR:0000243
IMR:0000245
PubMed:12461567
event
IEV:0002317
Activation of IKK complex by PKCs in cytosol
IMR:0000243
IMR:0001146
PubMed:12461567
event
IEV:0002318
Activation of IKK complex by PKC beta in cytosol
IMR:0100320
IMR:0100735
event
IEV:0002319
Binding of GH receptor and JAK2 in cytosol
IMR:0100320
IMR:0100735
event
IEV:0002320
Phosphorylation of GH receptor by JAK2 in cytosol
IMR:0100733
IMR:0100735
event
IEV:0002321
Binding of GH receptor and STAT5 in cytosol
IMR:0100320
IMR:0100733
event
IEV:0002322
Phosphorylation of STAT5 by JAK2_p in cytosol
IMR:0100733
IMR:0100735
event
IEV:0002323
Dissociation of GH receptor and STAT5 in cytosol
IMR:0100102
IMR:0100735
event
IEV:0002324
Binding of GH and GH receptor and conformational change of receptors in plasma membrane
IMR:0000276
IMR:0100735
event
IEV:0002325
Dephosphorylation of GHR_p by SHP-2 in cytosol
IMR:0000109
IMR:0100320
event
IEV:0002326
Binding of IL3 receptor and JAK2 in cytosol
IMR:0000109
IMR:0100320
event
IEV:0002327
Phosphorylation of IL-3 receptor by JAK2 in cytosol
IMR:0000109
IMR:0100733
event
IEV:0002328
Binding of IL-3 receptor and STAT5 in cytosol
IMR:0000109
IMR:0100733
event
IEV:0002329
Dissociation of IL-3 receptor and STAT5 in cytosol
IMR:0000111
IMR:0100319
IMR:0100321
event
IEV:0002330
Binding of IL-7 receptor and JAK1 and JAK3 in cytosol
IMR:0000111
IMR:0100319
IMR:0100321
event
IEV:0002331
Phosphorylation of IL-7 receptor by JAK1 and JAK3 in cytosol
IMR:0000111
IMR:0100733
event
IEV:0002332
Binding of IL-7 receptor and STAT5 in cytosol
IMR:0000111
IMR:0100733
event
IEV:0002333
Dissociation of IL-7 receptor and STAT5 in cytosol
Combining with interleukin-7 to initiate a change in cell activity.
IEV:0001346
GO:0005139
GO:0019982
IMR:0000111
IMR:0000586
Binding of IL7 and IL7 receptor and conformational change of receptors in plasma membrane
event
IEV:0002334
Binding of IL-7 and IL-7 receptor and conformational change of receptors in plasma membrane
Combining with interleukin-7 to initiate a change in cell activity.
XX:<new dbxref>
IMR:0000111
IMR:0000265
event
IEV:0002335
Binding of IL-7 R and PI3K in cytosol
IMR:0000265
IMR:0100319
event
IEV:0002336
Phosphorylation of PI3K by JAK1_p in cytosol
event
IEV:0002337
BMP2 signaling pathway(through Smad)
event
IEV:0002338
BMP2 signaling pathway(through TAK1)
event
IEV:0002339
TGF beta signaling pathway (through TAK1)
OBSOLETE: remap to 'Toll receptor signaling' IEV:0003490.
event
IEV:0002340
Drosophila Toll-like receptor signaling
true
OBSOLETE: remap to 'Toll receptor signaling' IEV:0003490.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of PGRP-SA and GNBP1' IEV:0003496.
event
IEV:0002341
Binding of PGRP-SA and GNBP1 [Drosophila]
true
OBSOLETE: remap to 'Binding of PGRP-SA and GNBP1' IEV:0003496.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of PGRP-SA:GNBP1 and PGN' IEV:0003497.
event
IEV:0002342
Binding of PGRP-SA:GNBP1 and PGN [Drosophila]
true
OBSOLETE: remap to 'Binding of PGRP-SA:GNBP1 and PGN' IEV:0003497.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of PGRP-SD and PGN' IEV:0003498.
event
IEV:0002343
Binding of PGRP-SD and PGN [Drosophila]
true
OBSOLETE: remap to 'Binding of PGRP-SD and PGN' IEV:0003498.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of GNBP3 and beta1-3 glucan' IEV:0003494.
event
IEV:0002344
Binding of GNBP3 and beta1-3 glucan [Drosophila]
true
OBSOLETE: remap to 'Binding of GNBP3 and beta1-3 glucan' IEV:0003494.
XX:<new dbxref>
OBSOLETE: remap to 'Activation of serine protease' IEV:0003491.
event
IEV:0002345
Activation of serine protease [Drosophila]
true
OBSOLETE: remap to 'Activation of serine protease' IEV:0003491.
XX:<new dbxref>
OBSOLETE: remap to 'Activation of PSH by GNBP3' IEV:0003492.
event
IEV:0002346
Activation of PSH by GNBP3 [Drosophila]
true
OBSOLETE: remap to 'Activation of PSH by GNBP3' IEV:0003492.
XX:<new dbxref>
OBSOLETE: remap to 'Activation of Spaetzle by serine protease' IEV:0003504.
event
IEV:0002347
Activation of Spaetzle by serine protease [Drosophila]
true
OBSOLETE: remap to 'Activation of Spaetzle by serine protease' IEV:0003504.
XX:<new dbxref>
OBSOLETE: remap to 'Activation of Spaetzle by PSH' IEV:0003503.
event
IEV:0002348
Activation of Spaetzle by PSH [Drosophila]
true
OBSOLETE: remap to 'Activation of Spaetzle by PSH' IEV:0003503.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of Toll and Spaetzle' IEV:0003500.
event
IEV:0002349
Binding of Toll and Spaetzle [Drosophila]
true
OBSOLETE: remap to 'Binding of Toll and Spaetzle' IEV:0003500.
XX:<new dbxref>
OBSOLETE: remap to 'Dimerization of Toll by Spaetzle' IEV:0003529.
event
IEV:0002350
Dimerization of Toll by Spaetzle [Drosophila]
true
OBSOLETE: remap to 'Dimerization of Toll by Spaetzle' IEV:0003529.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of Toll and MyD88:Tube' IEV:0003499.
event
IEV:0002351
Binding of Toll and dMyD88:Tube [Drosophila]
true
OBSOLETE: remap to 'Binding of Toll and MyD88:Tube' IEV:0003499.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of Toll:MyD88:Tube and Pelle' IEV:0003501.
event
IEV:0002352
Binding of Toll:dMyD88:Tube and Pelle [Drosophila]
true
OBSOLETE: remap to 'Binding of Toll:MyD88:Tube and Pelle' IEV:0003501.
XX:<new dbxref>
OBSOLETE: remap to 'Autophosphorylation of Pelle' IEV:0003493.
event
IEV:0002353
Autophosphorylation of Pelle [Drosophila]
true
OBSOLETE: remap to 'Autophosphorylation of Pelle' IEV:0003493.
XX:<new dbxref>
OBSOLETE: remap to 'Dissociation of Toll:MyD88:Tube and Pelle' IEV:0003530.
event
IEV:0002354
Dissociation of Toll:dMyD88:Tube and Pelle [Drosophila]
true
OBSOLETE: remap to 'Dissociation of Toll:MyD88:Tube and Pelle' IEV:0003530.
XX:<new dbxref>
OBSOLETE: remap to 'Phosphorylation of TRAF2 by Pelle_p' IEV:0003540.
event
IEV:0002355
Phosphorylation of dTRAF2 by Pelle_p [Drosophila]
true
OBSOLETE: remap to 'Phosphorylation of TRAF2 by Pelle_p' IEV:0003540.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of TRAF2 and Ref(2):DaPKC' IEV:0003495.
event
IEV:0002356
Binding of dTRAF2 and Ref(2):DaPKC [Drosophila]
true
OBSOLETE: remap to 'Binding of TRAF2 and Ref(2):DaPKC' IEV:0003495.
XX:<new dbxref>
OBSOLETE: remap to 'Nuclear import of TRAF2:Ref(2)P:DaPKC' IEV:0003539.
event
IEV:0002357
Nuclear import of dTRAF2:Ref(2)P:DaPKC [Drosophila]
true
OBSOLETE: remap to 'Nuclear import of TRAF2:Ref(2)P:DaPKC' IEV:0003539.
XX:<new dbxref>
OBSOLETE: remap to 'Phosphorylation of Cactus' IEV:0003522.
event
IEV:0002358
Phosphorylation of Cactus [Drosophila]
true
OBSOLETE: remap to 'Phosphorylation of Cactus' IEV:0003522.
XX:<new dbxref>
OBSOLETE: remap to 'Dissociation of Cactus_p and DIF' IEV:0003510.
event
IEV:0002359
Dissociation of Cactus_p and DIF [Drosophila]
true
OBSOLETE: remap to 'Dissociation of Cactus_p and DIF' IEV:0003510.
XX:<new dbxref>
OBSOLETE: remap to 'Dissociation of Cactus_p and Dorsal:DIF' IEV:0003524.
event
IEV:0002360
Dissociation of Cactus_p and Dorsal:DIF [Drosophila]
true
OBSOLETE: remap to 'Dissociation of Cactus_p and Dorsal:DIF' IEV:0003524.
XX:<new dbxref>
OBSOLETE: remap to 'Nuclear import of DIF' IEV:0003521.
event
IEV:0002361
Nuclear import of DIF [Drosophila]
true
OBSOLETE: remap to 'Nuclear import of DIF' IEV:0003521.
XX:<new dbxref>
OBSOLETE: remap to 'Nuclear import of Dorsal' IEV:0003538.
event
IEV:0002362
Nuclear import of Dorsal [Drosophila]
true
OBSOLETE: remap to 'Nuclear import of Dorsal' IEV:0003538.
XX:<new dbxref>
OBSOLETE: remap to 'Nuclear import of Dorsal:DIF' IEV:0003528.
event
IEV:0002363
Nuclear import of Dorsal:DIF [Drosophila]
true
OBSOLETE: remap to 'Nuclear import of Dorsal:DIF' IEV:0003528.
XX:<new dbxref>
OBSOLETE: remap to 'Activation of DIF' IEV:0003509.
event
IEV:0002364
Activation of DIF [Drosophila]
true
OBSOLETE: remap to 'Activation of DIF' IEV:0003509.
XX:<new dbxref>
OBSOLETE: remap to 'Activation of Dorsal' IEV:0003531.
event
IEV:0002365
Activation of Dorsal [Drosophila]
true
OBSOLETE: remap to 'Activation of Dorsal' IEV:0003531.
XX:<new dbxref>
OBSOLETE: remap to 'Activation of DIF:Dorsal' IEV:0003523.
event
IEV:0002366
Activation of DIF:Dorsal [Drosophila]
true
OBSOLETE: remap to 'Activation of DIF:Dorsal' IEV:0003523.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of DIF and NF-kappaB binding sequence' IEV:0003512.
event
IEV:0002367
Binding of DIF and NF-kappaB binding sequence [Drosophila]
true
OBSOLETE: remap to 'Binding of DIF and NF-kappaB binding sequence' IEV:0003512.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of Dorsal and NF-kappaB binding sequence' IEV:0003534.
event
IEV:0002368
Binding of Dorsal and NF-kappaB binding sequence [Drosophila]
true
OBSOLETE: remap to 'Binding of Dorsal and NF-kappaB binding sequence' IEV:0003534.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of DIF:Dorsal and NF-kappaB binding sequence' IEV:0003526.
event
IEV:0002369
Binding of DIF:Dorsal and NF-kappaB binding sequence [Drosophila]
true
OBSOLETE: remap to 'Binding of DIF:Dorsal and NF-kappaB binding sequence' IEV:0003526.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of antimicrobial peptide by DIF' IEV:0003517.
event
IEV:0002370
Transcription of antimicrobial peptide by DIF [Drosophila]
true
OBSOLETE: remap to 'Transcription of antimicrobial peptide by DIF' IEV:0003517.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of antimicrobial peptide by Dorsal' IEV:0003537.
event
IEV:0002371
Transcription of antimicrobial peptide by Dorsal [Drosophila]
true
OBSOLETE: remap to 'Transcription of antimicrobial peptide by Dorsal' IEV:0003537.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of antimicrobial peptide by DIF:Dorsal' IEV:0003527.
event
IEV:0002372
Transcription of antimicrobial peptide by DIF:Dorsal [Drosophila]
true
OBSOLETE: remap to 'Transcription of antimicrobial peptide by DIF:Dorsal' IEV:0003527.
XX:<new dbxref>
OBSOLETE: remap to 'DIF signaling' IEV:0003506.
event
IEV:0002373
DIF signaling [Drosophila]
true
OBSOLETE: remap to 'DIF signaling' IEV:0003506.
XX:<new dbxref>
OBSOLETE: remap to 'Dorsal signaling' IEV:0003507.
event
IEV:0002374
Dorsal signaling [Drosophila]
true
OBSOLETE: remap to 'Dorsal signaling' IEV:0003507.
XX:<new dbxref>
OBSOLETE: remap to 'DIF:Dorsal signaling' IEV:0003508.
event
IEV:0002375
DIF:Dorsal signaling [Drosophila]
true
OBSOLETE: remap to 'DIF:Dorsal signaling' IEV:0003508.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of antimicrobial peptide by Relish' IEV:0003464.
event
IEV:0002376
Expression of antimicrobial peptide by Relish [Drosophila]
true
OBSOLETE: remap to 'Expression of antimicrobial peptide by Relish' IEV:0003464.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of drosomycin by Relish' IEV:0003475.
event
IEV:0002377
Expression of drosomycin by Relish [Drosophila]
true
OBSOLETE: remap to 'Expression of drosomycin by Relish' IEV:0003475.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of cecropin by Relish' IEV:0002644.
event
IEV:0002378
Expression of cecropin by Relish [Drosophila]
true
OBSOLETE: remap to 'Expression of cecropin by Relish' IEV:0002644.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of diptericin by Relish' IEV:0003472.
event
IEV:0002379
Expression of diptericin by Relish [Drosophila]
true
OBSOLETE: remap to 'Expression of diptericin by Relish' IEV:0003472.
XX:<new dbxref>
OBSOLETE: remap to 'IMD signaling pathway' IEV:0003456.
event
IEV:0002380
Drosophila IMD pathway [Drosophila]
true
OBSOLETE: remap to 'IMD signaling pathway' IEV:0003456.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of PGRP-LC and PGN' IEV:0003465.
event
IEV:0002381
Binding of PGRP-LC and PGN [Drosophila]
true
OBSOLETE: remap to 'Binding of PGRP-LC and PGN' IEV:0003465.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of PGRP-LC and LPS' IEV:0003457.
event
IEV:0002382
Binding of PGRP-LC and LPS [Drosophila]
true
OBSOLETE: remap to 'Binding of PGRP-LC and LPS' IEV:0003457.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of PGRP-LE and PGN' IEV:0003466.
event
IEV:0002383
Binding of PGRP-LE and PGN [Drosophila]
true
OBSOLETE: remap to 'Binding of PGRP-LE and PGN' IEV:0003466.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of PGRP-LC and IMD' IEV:0003461.
event
IEV:0002384
Binding of PGRP-LC and IMD [Drosophila]
true
OBSOLETE: remap to 'Binding of PGRP-LC and IMD' IEV:0003461.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of IMD and FADD' IEV:0003463.
event
IEV:0002385
Binding of IMD and dFADD [Drosophila]
true
OBSOLETE: remap to 'Binding of IMD and FADD' IEV:0003463.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of FADD and caspase8' IEV:0003458.
event
IEV:0002386
Binding of dFADD and Dredd [Drosophila]
true
OBSOLETE: remap to 'Binding of FADD and caspase8' IEV:0003458.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of Dnr-1 and caspase8' IEV:0003462.
event
IEV:0002387
Binding of Dnr-1 and Dredd [Drosophila]
true
OBSOLETE: remap to 'Binding of Dnr-1 and caspase8' IEV:0003462.
XX:<new dbxref>
OBSOLETE: remap to 'Activation of TAK1 by IMD' IEV:0003459.
event
IEV:0002388
Activation of TAK1 by IMD [Drosophila]
true
OBSOLETE: remap to 'Activation of TAK1 by IMD' IEV:0003459.
XX:<new dbxref>
OBSOLETE: remap to 'Phosphorylation of IKK complex by TAK1' IEV:0000784.
event
IEV:0002389
Phosphorylation of DmIKK by TAK1 [Drosophila]
true
OBSOLETE: remap to 'Phosphorylation of IKK complex by TAK1' IEV:0000784.
XX:<new dbxref>
OBSOLETE: remap to 'Phosphorylation of Relish by IKK' IEV:0003469.
event
IEV:0002390
Phosphorylation of Relish by IKK [Drosophila]
true
OBSOLETE: remap to 'Phosphorylation of Relish by IKK' IEV:0003469.
XX:<new dbxref>
OBSOLETE: remap to 'Cleavage and activation of Relish by caspase8' IEV:0003467.
event
IEV:0002391
Cleavage and activation of Relish by Dredd [Drosophila]
true
OBSOLETE: remap to 'Cleavage and activation of Relish by caspase8' IEV:0003467.
XX:<new dbxref>
OBSOLETE: remap to 'Nuclear import of Relish' IEV:0003471.
event
IEV:0002392
Nuclear import of Relish [Drosophila]
true
OBSOLETE: remap to 'Nuclear import of Relish' IEV:0003471.
XX:<new dbxref>
OBSOLETE: remap to 'Binding of Relish and NF-kappaB binding sequence' IEV:0003468.
event
IEV:0002393
Binding of Relish and NF-kappaB binding sequence [Drosophila]
true
OBSOLETE: remap to 'Binding of Relish and NF-kappaB binding sequence' IEV:0003468.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of antimicrobial peptide by Relish' IEV:0003478.
event
IEV:0002394
Transcription of antimicrobial peptide by Relish [Drosophila]
true
OBSOLETE: remap to 'Transcription of antimicrobial peptide by Relish' IEV:0003478.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of drosocin by Relish' IEV:0003473.
event
IEV:0002395
Expression of drosocin by Relish [Drosophila]
true
OBSOLETE: remap to 'Expression of drosocin by Relish' IEV:0003473.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of attacin by Relish' IEV:0003474.
event
IEV:0002396
Expression of attacin by Relish [Drosophila]
true
OBSOLETE: remap to 'Expression of attacin by Relish' IEV:0003474.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of defensin by DIF:Relish' IEV:0003477.
event
IEV:0002397
Expression of defensin by DIF:Relish [Drosophila]
true
OBSOLETE: remap to 'Expression of defensin by DIF:Relish' IEV:0003477.
XX:<new dbxref>
OBSOLETE: remap to 'Dissociation of Cactus_p and Dorsal' IEV:0003532.
event
IEV:0002398
Dissociation of Cactus_p and Dorsal [Drosophila]
true
OBSOLETE: remap to 'Dissociation of Cactus_p and Dorsal' IEV:0003532.
XX:<new dbxref>
Reaction, that can affect K,C,A,D,E,Q,G,I,K,M,P,S,T,Y,V residues.
EC:2.3.1.12
EC:2.3.1.29
EC:2.3.1.4
EC:2.3.1.57
EC:2.3.1.87
EC:2.3.1.9
MI:0192
event
IEV:0002399
Transacetylation
Reaction, that can affect K,C,A,D,E,Q,G,I,K,M,P,S,T,Y,V residues.
MI:0192
IMR:0001721
IMR:0100150
event
IEV:0002400
Binding of Angiotensin II and AT1R in extracellular
IMR:0001721
IMR:0100378
event
IEV:0002401
Binding of AT1R and G alpha q in cytosol
IMR:0001354
IMR:0001721
IMR:0100018
IMR:0100366
event
IEV:0002402
Dissociation of AT1R, G alpha s-GTP and G beta:G gamma in cytosol
IMR:0000284
IMR:0001354
IMR:0100378
event
IEV:0002403
Binding of G alpha q-GTP and PLC in cytosol
IMR:0001729
IMR:0100119
event
IEV:0002404
Binding of Glutamate and Group I mGlu receptor in extracellular
IMR:0001729
IMR:0100378
event
IEV:0002405
Binding of Group I mGlu receptor and G alpha q in cytosol
IMR:0001354
IMR:0001729
IMR:0100018
IMR:0100378
event
IEV:0002406
Dissociation of Group I mGlu receptor, G alpha q-GTP and G beta:G gamma in cytosol
OBSOLETE: remap to 'Dissociation of NF-kappaB and I-kappaB' IEV:0000215.
event
IEV:0002407
Dissociation of NF-kappaB and I-kappaB [mammals]
true
OBSOLETE: remap to 'Dissociation of NF-kappaB and I-kappaB' IEV:0000215.
XX:<new dbxref>
REACT:1432.1
event
IEV:0002408
TNFR1 signaling pathway
event
IEV:0002409
TNFR2 signaling pathway
OBSOLETE: remap to 'Phosphorylation of I-kappaB_p by IKK complex_p in cytosol' IEV:0000213.
event
IEV:0002410
Phosphorylation of I-kappaB_p by IKK complex_p [mammals]
true
OBSOLETE: remap to 'Phosphorylation of I-kappaB_p by IKK complex_p in cytosol' IEV:0000213.
XX:<new dbxref>
IMR:0000232
IMR:0000329
IMR:0000441
IMR:0000893
IMR:0100427
PubMed:12620219
event
IEV:0002411
Binding of TRAF6:TAK1:TAB1:TAB2 complex and ubiquitin ligase in cytosol
IMR:0000066
IMR:0000226
event
IEV:0002412
Phosphorylation of p38 by KDR_p in cytosol
IMR:0000226
IMR:0001689
event
IEV:0002413
Phosphorylation of MAPKAPK2/3 by p38_p in cytosol
IMR:0001689
IMR:0001692
event
IEV:0002414
Phosphorylation of HSP27 by MAPKAPK2/3_p in cytosol
IMR:0000209
IMR:0000250
event
IEV:0002415
Phosphorylation of Akt by protein kinase in cytosol
IMR:0001761
IMR:0100113
event
IEV:0002416
Binding of Dopamine and D1-like receptor in extracellular
IMR:0001761
IMR:0100366
event
IEV:0002417
Binding of D1-like receptor and G alpha s in cytosol
IMR:0001354
IMR:0001761
IMR:0100018
IMR:0100366
event
IEV:0002418
Dissociation of D1-like receptor, G alpha s-GTP and G beta:G gamma in cytosol
IMR:0000722
IMR:0001354
IMR:0100366
event
IEV:0002419
Binding of G alpha s-GTP and adenylate cyclase type V in cytosol
IMR:0000722
IMR:0001351
IMR:0100024
event
IEV:0002420
Hydrolysis of ATP to cAMP by adenylate cyclase type V in cytosol
IMR:0000249
IMR:0000420
event
IEV:0002421
Phosphorylation of CREB by PKA in cytosol
IMR:0000249
IMR:0000280
event
IEV:0002422
Activation of PP2A by PKA in cytosol
IMR:0000249
IMR:0001763
event
IEV:0002423
Phosphorylation of DARPP-32 by PKA in cytosol
IMR:0000083
IMR:0000279
event
IEV:0002424
Dephosphorylation of NMDA glutamate receptor by PP1 in cytosol
IMR:0000279
IMR:0000749
event
IEV:0002425
Dephosphorylation of L-type Ca2+ channel_p by PP1 in cytosol
IMR:0000249
IMR:0000749
event
IEV:0002426
Phosphorylation of L-type Ca2+ channel by PKA in cytosol
IMR:0000083
IMR:0000249
event
IEV:0002427
Phosphorylation of NMDA glutamate receptor by PKA in cytosol
IMR:0001763
IMR:0100601
event
IEV:0002428
Phosphorylation of DARPP-32 by CDK5 in cytosol
IMR:0000280
IMR:0001763
event
IEV:0002429
Dephosphorylation of DARPP-32_p by PP2A in cytosol
IMR:0000710
IMR:0100331
PubMed:14687659
PubMed:15733830
event
IEV:0002430
Binding of TGF beta receptor I and XIAP in cytosol
IMR:0000441
IMR:0100331
PubMed:14687659
PubMed:15733830
event
IEV:0002431
Binding of XIAP and TAB1 in cytosol
IMR:0000232
IMR:0000441
PubMed:14687659
PubMed:15733830
event
IEV:0002432
Activation of TAK1 by TAB1 in cytosol
IMR:0100222
IMR:0100454
ISBN:4320055608
ISBN:4897060729
ISBN:4897065739
event
IEV:0002433
Phosphorylation of MKK4 by MEKK1 in cytosol
IMR:0000683
IMR:0100454
ISBN:4320055608
ISBN:4897060729
ISBN:4897065739
event
IEV:0002434
Phosphorylation of JNK1 by MKK4_p in cytosol
IMR:0000683
ISBN:4320055608
ISBN:4897060729
ISBN:4897065739
event
IEV:0002435
Nuclear import of JNK1_p
IMR:0000683
IMR:0000817
ISBN:4320055608
ISBN:4897060729
ISBN:4897065739
event
IEV:0002436
Phosphorylation of c-Jun by JNK1_p in inner space of nucleus
event
IEV:0002437
PKC delta activation signaling
IMR:0001148
IMR:0100027
event
IEV:0002438
Activation of PKC delta by DAG in cytosol
IMR:0000081
IMR:0100279
event
IEV:0002440
Binding of EGF and EGFR in extracellular
IMR:0000081
event
IEV:0002441
Dimerization of EGFR in plasma membrane
IMR:0000081
event
IEV:0002442
Autophosphorylation of EGFR in plasma membrane
true
IMR:0000081
IMR:0000347
event
IEV:0002444
Phosphorylation of Shc by EGFR_p in cytosol
true
IMR:0000290
IMR:0000435
event
IEV:0002446
Binding of Sos and Ras in cytosol
IMR:0000290
IMR:0001354
IMR:0100355
event
IEV:0002447
Activation of Raf1 by Ras-GTP in cytosol
IMR:0000290
IMR:0001354
IMR:0100222
event
IEV:0002448
Activation of MEKK1 by Ras-GTP in cytosol
IMR:0000261
IMR:0100355
event
IEV:0002449
Phosphorylation of MEK1/2(MKK1/2) by Raf1 in cytosol
IMR:0000227
IMR:0000261
event
IEV:0002450
Phosphorylation of ERK1/2 by MEK1/2(MKK1/2)_p in cytosol
IMR:0000068
IMR:0000347
event
IEV:0002451
Phosphorylation of Shc by PDGF Receptor_p in cytosol
true
IMR:0000033
IMR:0000071
event
IEV:0002453
Binding of HGF and Met in extracellular
IMR:0000071
event
IEV:0002454
Dimerization of Met in plasma membrane
IMR:0000071
event
IEV:0002455
Autophosphorylation of Met in plasma membrane
IMR:0000071
IMR:0100575
event
IEV:0002456
Binding of Met_p and Src in cytosol
IMR:0000071
IMR:0001410
event
IEV:0002457
Binding of Met_p and Gab1 in cytosol
IEV:0002468
IMR:0000071
IMR:0000340
Binding of (HGF:Met_p) and (Grb2:Sos)
event
IEV:0002458
Binding of Met_p and Grb2 in cytosol
IMR:0000340
IMR:0001410
event
IEV:0002459
Binding of Gab1 and Grb2 in cytosol
IMR:0000285
IMR:0001410
event
IEV:0002460
Binding of Gab1 and PLC gamma in cytosol
IMR:0000276
IMR:0001410
event
IEV:0002461
Binding of Gab1 and SHP-2 in cytosol
true
IMR:0000335
IMR:0001410
event
IEV:0002463
Binding of Gab1 and Crk in cytosol
IMR:0000335
IMR:0001468
event
IEV:0002464
Binding of Crk and Dock180 in cytosol
IMR:0000297
IMR:0001468
event
IEV:0002465
Binding of Dock180 and Rac in cytosol
IMR:0000436
IMR:0001504
event
IEV:0002466
Binding of C3G and Rap1 in cytosol
true
true
IMR:0000071
IMR:0000347
event
IEV:0002469
Phosphorylation of Shc by Met_p in cytosol
IMR:0000072
IMR:0100407
event
IEV:0002470
Binding of NGF and TRK in extracellular
IMR:0000072
event
IEV:0002471
Dimerization of TRK in plasma membrane
IMR:0000072
event
IEV:0002472
Autophosphorylation of TRK in plasma membrane
true
IMR:0000072
IMR:0000347
event
IEV:0002474
Phosphorylation of Shc by TRK_p in cytosol
true
IMR:0000072
IMR:0000285
event
IEV:0002476
Binding of TRK_p and PLC gamma in cytosol
IMR:0000072
IMR:0000285
event
IEV:0002477
Phosphorylation of PLC gamma by TRK_p in cytosol
IMR:0000031
IMR:0000066
event
IEV:0002478
Binding of VEGF and KDR in extracellular
IMR:0000066
event
IEV:0002479
Dimerization of KDR in plasma membrane
IMR:0000066
event
IEV:0002480
Autophosphorylation of KDR in plasma membrane
IMR:0000066
IMR:0000265
event
IEV:0002481
Binding of KDR_p and PI3K in cytosol
IMR:0000066
IMR:0001652
event
IEV:0002482
Binding of KDR_p and VRAP in cytosol
IMR:0000066
IMR:0000285
event
IEV:0002483
Binding of KDR_p and PLC gamma in cytosol
IMR:0000245
IMR:0100027
event
IEV:0002484
Activation of PKC by DAG in cytosol
IMR:0000245
IMR:0100355
Activation of c-Raf1 by PKC
event
IEV:0002485
Activation of Raf-1 by PKC in cytosol
IMR:0000049
IMR:0000080
event
IEV:0002486
Binding of FGF and FGFR in extracellular
IMR:0000080
event
IEV:0002487
Dimerization of FGFR in plasma membrane
IMR:0000080
event
IEV:0002488
Autophosphorylation of FGFR in plasma membrane
IMR:0000080
IMR:0000285
event
IEV:0002489
Binding of FGFR_p and PLC gamma in cytosol
IMR:0000080
IMR:0001836
event
IEV:0002490
Binding of FGFR_p and FRS2 in cytosol
IMR:0000080
IMR:0001836
event
IEV:0002491
Phosphorylation of FRS2 by FGFR_p in cytosol
IMR:0000340
IMR:0001836
event
IEV:0002492
Binding of Grb2 and FRS2_p in cytosol
IMR:0001410
IMR:0001836
event
IEV:0002493
Phosphorylation of Gab1 by FRS2 in cytosol
IEV:0002462
IMR:0000265
IMR:0001410
Binding of Gab1 and PI3K
event
IEV:0002494
Binding of Gab1_p and PI3K in cytosol
IMR:0000265
IMR:0000290
event
IEV:0002495
Binding of Ras and PI3K in cytosol
IMR:0001372
IMR:0100471
event
IEV:0002496
Binding of Ci/Gli and Slmb/beta-TrCP in cytosol
IMR:0000702
IMR:0001424
IMR:0001425
event
IEV:0002497
Binding of BMP2:BMP receptor I and BMP receptor II in plasma membrane
IMR:0001425
IMR:0100331
event
IEV:0002498
Binding of BMP receptor I and XIAP in cytosol
IMR:0000232
IMR:0100317
event
IEV:0002499
Binding of Smad6 and TAK1 in cytosol
event
IEV:0002500
Ventral mesoderm specification
event
IEV:0002501
Regulation of BMP2 signaling pathway (through Smad)
event
IEV:0002502
Negative regulation of BMP2 signaling pathway (through Smad)
event
IEV:0002503
Positive regulation of BMP2 signaling pathway (through Smad)
event
IEV:0002504
Regulation of BMP2 signaling pathway (through TAK1)
event
IEV:0002505
Negative regulation of BMP2 signaling pathway (through TAK1)
event
IEV:0002506
Positive regulation of BMP2 signaling pathway (through TAK1)
IMR:0000702
IMR:0001831
event
IEV:0002507
Binding of BMP receptor II and BAMBI in cytosol
IMR:0001425
IMR:0100318
event
IEV:0002508
Binding of BMP receptor I and Smad7 in cytosol
IMR:0001425
IMR:0100317
event
IEV:0002509
Binding of BMP receptor I and Smad6 in cytosol
IMR:0100310
IMR:0100317
event
IEV:0002510
Binding of Smad1_p and Smad6 in cytosol
OBSOLETE: remap to 'Binding of DIF:Relish and NF-kappaB binding sequence' IEV:0003460.
event
IEV:0002511
Binding of DIF:Relish and NF-kappaB binding sequence [Drosophila]
true
OBSOLETE: remap to 'Binding of DIF:Relish and NF-kappaB binding sequence' IEV:0003460.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of defensin by DIF:Relish' IEV:0003481.
event
IEV:0002512
Transcription of defensin by DIF:Relish [Drosophila]
true
OBSOLETE: remap to 'Transcription of defensin by DIF:Relish' IEV:0003481.
XX:<new dbxref>
OBSOLETE: remap to 'Regulation of Toll receptor signaling' IEV:0003569.
event
IEV:0002513
Regulation of Drosophila Toll receptor signaling
true
OBSOLETE: remap to 'Regulation of Toll receptor signaling' IEV:0003569.
XX:<new dbxref>
Any process that stops, prevents or reduces the frequency, rate or extent of the Tl signaling pathway.
GO:0045751
Negative regulation of Toll receptor signaling pathway
down regulation of Toll signaling pathway
negative regulation of Tl signaling pathway
event
IEV:0002514
Negative regulation of Toll receptor signaling
Any process that stops, prevents or reduces the frequency, rate or extent of the Tl signaling pathway.
GO:0045751
Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway.
GO:0045752
Positive regulation of Toll receptor signaling pathway
positive regulation of Tl signaling pathway
up regulation of Toll signaling pathway
event
IEV:0002515
Positive regulation of Toll receptor signaling
Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway.
GO:0045752
event
IEV:0002516
Negative regulation of (Activation of PSH by GNBP3)
IMR:0001796
IMR:0001797
event
IEV:0002517
Binding of PSH and NEC in extracellular
IMR:0000310
IMR:0001805
event
IEV:0002518
Proteasome degradation of Cactus_p by 26S proteasome in cytosol
A defense response that is mediated by cells.
GO:0006968
cellular defense response
event
IEV:0002519
Cellular defense (Activated blood cell)
A defense response that is mediated by cells.
GO:0006968
cellular defense response
GO:0006968
IMR:0001425
IMR:0100310
event
IEV:0002520
Phosphorylation of Smad1 by BMP receptor I_p in cytosol
IMR:0001948
IMR:0100310
IMR:0100315
event
IEV:0002521
Binding of Smad1_p:Smad4 and OAZ in inner space of nucleus
IMR:0001948
IMR:0100310
IMR:0100315
event
IEV:0002522
Binding of Smad1:Smad4:OAZ complex and BRE in inner space of nucleus
IMR:0000172
PubMed:10446041
PubMed:15179030
event
IEV:0002523
Clustering of integrins in plasma membrane
event
IEV:0002524
Clustering
event
IEV:0002525
Clustering in plasma membrane
IMR:0000172
IMR:0000347
IMR:0001647
IMR:0100352
event
IEV:0002526
Complex formation of integrin complex, caveolin-1, Fyn and Shc
IMR:0000173
IMR:0001647
event
IEV:0002527
Binding of integrin alpha and caveolin-1 in plasma membrane
IMR:0001647
IMR:0100352
event
IEV:0002528
Binding of caveolin-1 and Fyn in plasma membrane
IMR:0000172
IMR:0000347
IMR:0000515
IMR:0100352
event
IEV:0002529
Complex formation of integrin complex, caveolin, Fyn and Shc
IMR:0001354
IMR:0001357
IMR:0001501
IMR:0001954
event
IEV:0002530
GDP-GTP exchange of Rac1 by RhoGEF in cytosol
IMR:0000699
IMR:0001354
IMR:0001357
IMR:0001954
event
IEV:0002531
GDP-GTP exchange of Cdc42 by RhoGEF in cytosol
IMR:0001354
IMR:0001357
IMR:0001953
IMR:0001954
event
IEV:0002532
GDP-GTP exchange of RhoA by RhoGEF in cytosol
IMR:0100615
event
IEV:0002533
Transcription of cyclin D1 gene in nucleus
The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon.
GO:0046847
filopodia biosynthesis
filopodia formation
event
IEV:0002534
Filopodium formation
The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon.
GO:0046847
Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
GO:0001709
event
IEV:0002535
Cell fate determination
Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
GO:0001709
Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
GO:0007500
mesoderm cell fate determination
event
IEV:0002536
Mesodermal cell fate determination
Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
GO:0007500
mesoderm cell fate determination
GO:0007500
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
GO:0007498
event
IEV:0002537
Mesoderm development
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
GO:0007498
GO:0048332
event
IEV:0002538
Mesoderm morphogenesis
event
IEV:0002539
Wnt secretory pathway
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
GO:0007492
event
IEV:0002540
Endoderm development
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
GO:0007492
Process by which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
GO:0007493
endoderm cell fate determination
event
IEV:0002541
Endodermal cell fate determination
Process by which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
GO:0007493
endoderm cell fate determination
GO:0007493
REACT:11045.1
event
IEV:0002542
Signaling with Wnt
event
IEV:0002543
Signaling without Wnt
IMR:0000177
event
IEV:0002544
Stabilization and accumulation of cytoplasmic beta-catenin in cytosol
event
IEV:0002545
Accumulation
event
IEV:0002546
Accumulation in cytosol
IMR:0001978
event
IEV:0002547
Transcription of Ubx gene in nucleus
IMR:0001979
event
IEV:0002548
Transcription of Engrailed gene in nucleus
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
event
IEV:0002549
Wnt signaling pathway (C. elegans)
true
OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027.
XX:<new dbxref>
IMR:0001977
event
IEV:0002550
Transcription of end-1 gene in nucleus
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
event
IEV:0002551
Transcription by beta-catenin TCF complex (C. elegans)
true
OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282.
XX:<new dbxref>
IMR:0000232
IMR:0001164
event
IEV:0002552
Activation of NLK by TAK1 in cytosol
IMR:0001197
event
IEV:0002553
Activation of APR-1 in cytosol
IMR:0000205
event
IEV:0002554
Activation of APC in cytosol
IMR:0100737
event
IEV:0002555
Activation of GSK3beta in cytosol
IMR:0001246
event
IEV:0002556
Activation of SGG-1 in cytosol
IMR:0100714
IMR:0100720
event
IEV:0002557
Binding of Notch1 and Delta1 in extracellular
IMR:0001919
IMR:0100712
event
IEV:0002558
Binding of Notch and Serrate/Jagged in extracellular
IMR:0001852
IMR:0100712
event
IEV:0002559
Glycosylation of Notch by Fringe in cytosol
The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Reaction that can affect Ser, Thr, Cys, Arg, and Asn residues. This reaction is known to be reversible in the case of Asn substrate.
EC:2.4.-.-
MI:0559
event
IEV:0002560
Glycosylation
The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Reaction that can affect Ser, Thr, Cys, Arg, and Asn residues. This reaction is known to be reversible in the case of Asn substrate.
MI:0559
event
IEV:0002561
Glycosylation in cytosol
IMR:0001955
IMR:0100712
event
IEV:0002562
Binding of Notch (ICN) and Numb in cytosol
IMR:0001943
IMR:0100712
event
IEV:0002563
Ubiquitination of Notch by Su(dx)/Itch in cytosol
event
IEV:0002564
Notch degradation signaling
IMR:0100712
event
IEV:0002565
Phosphorylation of Notch (NIC) in cytosol
IMR:0001931
IMR:0100470
IMR:0100712
event
IEV:0002566
Ubiquitination of Notch (NIC) by SCF ubiquitin ligase complex including sel-10 in cytosol
IMR:0000310
IMR:0100712
event
IEV:0002567
Proteasome degradation of Notch (NIC) by 26S proteasome in cytosol
event
IEV:0002568
Notch secretory pathway
IMR:0001980
event
IEV:0002569
Transcription of HES gene in nucleus
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
GO:0007224
KEGG:hsa04340
hh signaling pathway
smoothened signaling pathway
event
IEV:0002570
Hedgehog signaling pathway
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
GO:0007224
hh signaling pathway
GO:0007224
smoothened signaling pathway
GO:0007224
Covalent bond breakage in a molecule leading to the formation of smaller molecules.
MI:0194
event
IEV:0002571
Cleavage
Covalent bond breakage in a molecule leading to the formation of smaller molecules.
MI:0194
event
IEV:0002572
Autocleavage
event
IEV:0002573
Cholesterol modification
event
IEV:0002574
Cholesterol modification in ER
event
IEV:0002575
Autocleavage in ER
event
IEV:0002576
Secretory pathway of Hedgehog
true
true
IMR:0000004
event
IEV:0002579
Palmitoylation of hedgehog in ER
IMR:0000004
event
IEV:0002580
Translocation of hedgehog from ER to plasma membrane
The movement of substances between cells in a multicellular organism.
GO:0010496
Cell-to-cell movement
event
IEV:0002581
Intercellular transport
The movement of substances between cells in a multicellular organism.
GO:0010496
IMR:0000004
event
IEV:0002582
cell-to-cell movement of Hedgehog
IMR:0001125
event
IEV:0002583
Translocation of HSPG from Golgi to plasma membrane
IMR:0002958
event
IEV:0002584
Translocation of Dlp/Dally from Golgi to plasma membrane
IMR:0001125
IMR:0001396
event
IEV:0002585
Glycosylation of HSPG by Exostosin in cytosol
IMR:0001392
IMR:0002958
event
IEV:0002586
Glycosylation of Dlp/Dally by Tout-velu in cytosol
IMR:0100802
event
IEV:0002587
Activation of Smo
IMR:0000141
IMR:0100802
event
IEV:0002588
Inactivation of Smo by Ptc in plasma membrane
IMR:0000004
IMR:0000141
event
IEV:0002589
Inactivation of Ptc by Hedgehog in extracellular
IMR:0000141
IMR:0100802
event
IEV:0002590
Binding of Ptc and Smo in plasma membrane
IMR:0000004
IMR:0000141
event
IEV:0002591
Binding of Hedgehog and Ptc in extracellular
IMR:0001372
IMR:0100802
IMR:0100806
IMR:0100807
event
IEV:0002592
Binding of Smo and Cos2:Fu:Ci/Gli in cytosol
IMR:0001372
IMR:0003011
event
IEV:0002594
Binding of Sufu and Ci/Gli in cytosol
IMR:0001372
IMR:0100806
IMR:0100807
event
IEV:0002595
Binding of Ci/Gli, Fu and Cos2 in cytosol
event
IEV:0002596
Ci/Gli processing signaling
IMR:0000249
IMR:0001372
event
IEV:0002597
Phosphorylation of Ci/Gli by PKA in cytosol
IMR:0001372
IMR:0100809
event
IEV:0002598
Phosphorylation of Ci/Gli by CK1 in cytosol
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
GO:0045165
event
IEV:0002599
Cell fate commitment
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
GO:0045165
IMR:0000257
IMR:0001372
event
IEV:0002600
Phosphorylation of Ci/Gli by GSK3 in cytosol
event
IEV:0002601
Cleavage in cytosol
IMR:0001372
event
IEV:0002602
Cleavage of Ci/Gli in cytosol
IMR:0001372
event
IEV:0002603
Nuclear import of Ci/Gli
IMR:0001372
event
IEV:0002604
Nuclear import of Ci/GliR
IMR:0000004
event
IEV:0002605
Transcription of Hh target gene in nucleus
IMR:0000141
event
IEV:0002606
Transcription of ptc gene in nucleus
IMR:0001981
event
IEV:0002607
Transcription of dpp gene in nucleus
Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.
GO:0045168
event
IEV:0002608
Cell-cell signaling involved in cell fate commitment
Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.
GO:0045168
Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other.
GO:0031128
event
IEV:0002609
Induction
Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other.
GO:0031128
Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.
GO:0046331
event
IEV:0002610
Lateral inhibition
Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.
GO:0046331
Any process that mediates the transfer of information from one cell to another.
GO:0007267
event
IEV:0002611
Cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
GO:0007267
event
IEV:0002612
Translocation from ER to Golgi
event
IEV:0002613
Translocation from Golgi to cytosol
event
IEV:0002614
Translocation from cytosol to Golgi
IMR:0002951
event
IEV:0002615
Translocation of Arrow/LRP5/6 from ER to Golgi
IMR:0000970
event
IEV:0002616
Translocation of LRP6 from ER to Golgi
IMR:0002951
event
IEV:0002617
Translocation of Arrow/LRP5/6 from Golgi to plasma membrane
IMR:0000970
event
IEV:0002618
Translocation of LRP6 from Golgi to plasma membrane
IMR:0001909
IMR:0100712
event
IEV:0002619
Binding of Notch and Serrate in extracellular
IMR:0001935
IMR:0100712
event
IEV:0002620
Binding of Notch (ICN) and Deltex in cytosol
IMR:0001959
IMR:0100712
IMR:0100723
event
IEV:0002621
Binding of Notch (ICN):CSL and Nrarp in inner space of nucleus
OBSOLETE: remap to 'Dissociation of Axin, APC, GSK3beta and beta-catenin in cytosol' IEV:0003870.
event
IEV:0002622
Dissociation of Axin, APC, GSK3beta and beta-catenin
true
OBSOLETE: remap to 'Dissociation of Axin, APC, GSK3beta and beta-catenin in cytosol' IEV:0003870.
XX:<new dbxref>
IEV:0002445
IMR:0000081
IMR:0000340
Binding of (GRB2:SOS) and (EGF:EGFR_p)
event
IEV:0002623
Binding of EGFR and Grb2 in cytosol
IEV:0002443
IMR:0000081
IMR:0000347
Binding of SHC and (EGF:EGFR_p)
event
IEV:0002624
Binding of EGFR and Shc in cytosol
IMR:0000227
event
IEV:0002625
Nuclear import of ERK1/2_p
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
GO:0008543
FGF signaling pathway
FGFR signaling pathway
fibroblast growth factor receptor signaling pathway
event
IEV:0002626
FGF receptor signaling pathway
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
GO:0008543
FGF signaling pathway
GO:0008543
FGFR signaling pathway
GO:0008543
fibroblast growth factor receptor signaling pathway
GO:0008543
The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.
GO:0048012
HGF signaling pathway
HGFR signaling pathway
hepatocyte growth factor receptor signaling pathway
event
IEV:0002627
HGF receptor signaling pathway
The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.
GO:0048012
HGFR signaling pathway
GO:0048012
hepatocyte growth factor receptor signaling pathway
GO:0048012
IEV:0002467
IMR:0000071
IMR:0000347
Binding of (HGF:Met_p) and Shc
event
IEV:0002628
Binding of Met_p and Shc in cytosol
IEV:0002473
IMR:0000072
IMR:0000347
Binding of SHC and (NGF:TRK_p)
event
IEV:0002629
Binding of TRK and Shc in cytosol
IEV:0002475
IMR:0000072
IMR:0000340
Binding of (NGF:TRK_p) and (GRB2:SOS)
event
IEV:0002630
Binding of TRK and Grb2 in cytosol
IMR:0000063
IMR:0000347
event
IEV:0002631
Phosphorylation of Shc by RTK in cytosol
The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
GO:0048010
KEGG:hsa04370
VEGF signaling pathway
vascular endothelial growth factor receptor signaling pathway
event
IEV:0002632
VEGF receptor signaling pathway
The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
GO:0048010
VEGF signaling pathway
GO:0048010
vascular endothelial growth factor receptor signaling pathway
GO:0048010
event
IEV:0002633
Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
event
IEV:0002634
Heterotrimeric GPCR signaling pathway (through G alpha q)
event
IEV:0002635
Heterotrimeric GPCR signaling pathway (through G alpha o)
event
IEV:0002636
Heterotrimeric GPCR signaling pathway (through G alpha t)
event
IEV:0002637
Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)
IMR:0001815
event
IEV:0002638
Translation of antimicrobial protein in cytosol
OBSOLETE: remap to 'Translation of Defensin' IEV:0003487.
event
IEV:0002639
Translation of Defensin [Drosophila]
true
OBSOLETE: remap to 'Translation of Defensin' IEV:0003487.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of drosocin by Relish' IEV:0003482.
event
IEV:0002640
Transcription of drosocin by Relish [Drosophila]
true
OBSOLETE: remap to 'Transcription of drosocin by Relish' IEV:0003482.
XX:<new dbxref>
OBSOLETE: remap to 'Translation of drosocin' IEV:0003488.
event
IEV:0002641
Translation of drosocin [Drosophila]
true
OBSOLETE: remap to 'Translation of drosocin' IEV:0003488.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of attacin by Relish' IEV:0003476.
event
IEV:0002642
Transcription of attacin by Relish [Drosophila]
true
OBSOLETE: remap to 'Transcription of attacin by Relish' IEV:0003476.
XX:<new dbxref>
OBSOLETE: remap to 'Translation of attacin' IEV:0003485.
event
IEV:0002643
Translation of attacin [Drosophila]
true
OBSOLETE: remap to 'Translation of attacin' IEV:0003485.
XX:<new dbxref>
IMR:0001814
IMR:0001819
Expression of cecropin by Relish [Drosophila]
event
IEV:0002644
Expression of cecropin by Relish
OBSOLETE: remap to 'Transcription of cecropin by Relish' IEV:0003480.
event
IEV:0002645
Transcription of cecropin by Relish [Drosophila]
true
OBSOLETE: remap to 'Transcription of cecropin by Relish' IEV:0003480.
XX:<new dbxref>
OBSOLETE: remap to 'Translation of cecropin' IEV:0003486.
event
IEV:0002646
Translation of cecropin [Drosophila]
true
OBSOLETE: remap to 'Translation of cecropin' IEV:0003486.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of diptericin by Relish' IEV:0003483.
event
IEV:0002647
Transcription of diptericin by Relish [Drosophila]
true
OBSOLETE: remap to 'Transcription of diptericin by Relish' IEV:0003483.
XX:<new dbxref>
OBSOLETE: remap to 'Translation of diptericin' IEV:0003489.
event
IEV:0002648
Translation of diptericin [Drosophila]
true
OBSOLETE: remap to 'Translation of diptericin' IEV:0003489.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of drosomycin by Relish' IEV:0003479.
event
IEV:0002649
Transcription of drosomycin by Relish [Drosophila]
true
OBSOLETE: remap to 'Transcription of drosomycin by Relish' IEV:0003479.
XX:<new dbxref>
OBSOLETE: remap to 'Translation of drosomycin' IEV:0003484.
event
IEV:0002650
Translation of drosomycin [Drosophila]
true
OBSOLETE: remap to 'Translation of drosomycin' IEV:0003484.
XX:<new dbxref>
IMR:0000209
IMR:0001802
event
IEV:0002651
Activation of protein kinase by Pelle in cytosol
event
IEV:0002652
Activation in nucleus
event
IEV:0002653
Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)
OBSOLETE: remap to 'Transcription of antimicrobial peptide' IEV:0003518.
event
IEV:0002654
Transcription of antimicrobial peptide [Drosophila]
true
OBSOLETE: remap to 'Transcription of antimicrobial peptide' IEV:0003518.
XX:<new dbxref>
IMR:0000126
IMR:0100320
event
IEV:0002655
Binding of TPO receptor and JAK2 in cytosol
IMR:0000015
IMR:0000126
event
IEV:0002656
Binding of TPO and TPO receptor and conformational change of receptors in plasma membrane
IMR:0000126
IMR:0100320
event
IEV:0002657
Phosphorylation of TPO receptor by JAK2 in cytosol
IMR:0000126
IMR:0000377
event
IEV:0002658
Binding of TPO receptor and STAT3 in cytosol
IMR:0000377
IMR:0100320
event
IEV:0002659
Phosphorylation of STAT3 by JAK2_p in cytosol
IMR:0000126
IMR:0000377
event
IEV:0002660
Dissociation of TPO receptor and STAT3 in cytosol
Interaction leading to the formation of covalent bond within an autocatalytic molecule or between partners.
MI:0195
event
IEV:0002661
Covalent binding
Interaction leading to the formation of covalent bond within an autocatalytic molecule or between partners.
MI:0195
co-occurrence of interactors in a limited subcellular location or similar distribution in various regions of a cell.
MI:0403
PubMed:14755292
event
IEV:0002662
Colocalization
co-occurrence of interactors in a limited subcellular location or similar distribution in various regions of a cell.
MI:0403
Covalent bond mediated by 2 sulfur atoms.
MI:0408
event
IEV:0002663
Disulfide binding
Covalent bond mediated by 2 sulfur atoms.
MI:0408
Gln-Lys cross-link catalyzed by a transglutaminase.
MI:0566
event
IEV:0002664
Transglutamination
Gln-Lys cross-link catalyzed by a transglutaminase.
MI:0556
Covalent bond breakage of a DNA molecule leading to the formation of smaller fragements.
MI:0572
event
IEV:0002665
DNA cleavage
Covalent bond breakage of a DNA molecule leading to the formation of smaller fragements.
MI:0572
Cleavage of a lipid group covalently bound to a protein residue.
MI:0212
event
IEV:0002666
lipid cleavage
Cleavage of a lipid group covalently bound to a protein residue.
MI:0212
S-farnesyl-L-cysteined is cleaved and returns a C residue.
MI:0198
event
IEV:0002667
Defarnesylation
S-farnesyl-L-cysteined is cleaved and returns a C residue.
MI:0198
S-geranylgeranyl-L-cysteine is cleaved and returns a C residue.
MI:0200
event
IEV:0002668
Degeranylation
S-geranylgeranyl-L-cysteine is cleaved and returns a C residue.
MI:0200
N6-myristoyl-L-lysine is cleaved and returns a K residue.
MI:0201
event
IEV:0002669
Demyristoylation
N6-myristoyl-L-lysine is cleaved and returns a K residue.
MI:0201
S-palmitoyl-L-cysteine, N6-palmitoyl-L-lysine, O-palmitoyl-L-threonine or O-palmitoyl-L-serine are cleaved and return C,K,T or S residues.
MI:0202
event
IEV:0002670
Depalmitoylation
S-palmitoyl-L-cysteine, N6-palmitoyl-L-lysine, O-palmitoyl-L-threonine or O-palmitoyl-L-serine are cleaved and return C,K,T or S residues.
MI:0202
Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
MI:0571
event
IEV:0002671
mRNA cleavage
Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
MI:0571
Covalent modification of a polypeptide occuring during its maturation or its proteolytic degradation.
MI:0570
event
IEV:0002672
Protein cleavage
Covalent modification of a polypeptide occuring during its maturation or its proteolytic degradation.
MI:0570
Reaction catalyzed by PNGase, a deglycosylating enzyme that promotes the hydrolysis of the beta-aspartylglycosylamine bond of aspargine-linked glycopeptides and glycoproteins.
MI:0558
event
IEV:0002673
Deglycosylation
Reaction catalyzed by PNGase, a deglycosylating enzyme that promotes the hydrolysis of the beta-aspartylglycosylamine bond of aspargine-linked glycopeptides and glycoproteins.
MI:0558
Reaction that can affect K or G residues.
EC:2.1.2.2
EC:2.1.2.3
EC:2.1.2.9
MI:0207
event
IEV:0002674
Formylation
Reaction that can affect K or G residues.
MI:0207
Irreversible reaction that can affect A,R,N,D,C,Q,E,G,H,I,L,K,M,F,P,S,T,W,Y or V residues.
EC:6.3.1.-
MI:0193
event
IEV:0002675
Amidation
Irreversible reaction that can affect A,R,N,D,C,Q,E,G,H,I,L,K,M,F,P,S,T,W,Y or V residues.
MI:0193
N6-formyl-L-lysine is cleaved and returns a K residue.
MI:0199
event
IEV:0002676
Deformylation
N6-formyl-L-lysine is cleaved and returns a K residue.
MI:0199
Reversible reaction that create a covalent bond between a Glycine residue of an ubiquitine like NEDD8 protein and a lysine residue of the target.
MI:0567
event
IEV:0002677
Neddylation
Reversible reaction that create a covalent bond between a Glycine residue of an ubiquitine like NEDD8 protein and a lysine residue of the target.
MI:0567
Cleavage of the G-K bond and release of the NEDD8 ubiquitin like proteins. Deneddylation, which removes the NEDD8 moiety, requires the isopeptidase activity of the COP9 signalosome.
MI:0569
event
IEV:0002678
Deneddylation
Cleavage of the G-K bond and release of the NEDD8 ubiquitin like proteins. Deneddylation, which removes the NEDD8 moiety, requires the isopeptidase activity of the COP9 signalosome.
MI:0569
Cleavage of the G-K bond and release of the SUMO ubiquitin like proteins.
MI:0568
event
IEV:0002679
Desumoylation
Cleavage of the G-K bond and release of the SUMO ubiquitin like proteins.
MI:0568
Cleavage of the G-K bond and release of ubiquitin or ubiquitin like proteins.
MI:0204
event
IEV:0002680
Deubiquitination
Cleavage of the G-K bond and release of ubiquitin or ubiquitin like proteins.
MI:0204
Covalent or non covalent binding of lipid group on a protein residue.
MI:0211
event
IEV:0002681
lipid addition
Covalent or non covalent binding of lipid group on a protein residue.
MI:0211
Functional relationship among genes revealed by the phenotype of cells carrying combined mutations of those genes.
MI:0208
PubMed:14755292
event
IEV:0002682
genetic interaction
Functional relationship among genes revealed by the phenotype of cells carrying combined mutations of those genes.
MI:0208
A supressed gene mutation cause of an altered phenotype that is reverted to wild type phenotype when cell also carry a suppressor gene with a specific mutation or altered expression level.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796.
MI:0261
event
IEV:0002683
suppression
true
A supressed gene mutation cause of an altered phenotype that is reverted to wild type phenotype when cell also carry a suppressor gene with a specific mutation or altered expression level.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796.
MI:0261
An altered expression is the suppressor of a phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'expression level alteration' MI:0803.
MI:0265
event
IEV:0002684
suppression expression alteration
true
An altered expression is the suppressor of a phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'expression level alteration' MI:0803.
MI:0265
Overexpression is the suppressor of a phenotpe.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'over expressed' MI:0506.
MI:0266
event
IEV:0002685
suppression overexpression
true
Overexpression is the suppressor of a phenotpe.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'over expressed' MI:0506.
MI:0266
Underexpression is the suppressor of a phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'under expressed' MI:0223.
MI:0268
event
IEV:0002686
suppression underexpression
true
Underexpression is the suppressor of a phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'under expressed' MI:0223.
MI:0268
a given (suppressed) mutation phenotype is reverted by a supressor gene mutation.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'mutated gene' MI:0804.
MI:0262
event
IEV:0002687
suppression mutation
true
a given (suppressed) mutation phenotype is reverted by a supressor gene mutation.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'mutated gene' MI:0804.
MI:0262
Knocked out gene is the suppressor of a phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'knock out' MI:0788.
MI:0263
event
IEV:0002688
suppression knockout
true
Knocked out gene is the suppressor of a phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'knock out' MI:0788.
MI:0263
A mutation is the partial suppressor of a mutant phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'knock down' MI:0789.
MI:0264
event
IEV:0002689
suppression partial alteration
true
A mutation is the partial suppressor of a mutant phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'knock down' MI:0789.
MI:0264
Two silent mutations show an altered phenotype when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794.
MI:0269
event
IEV:0002690
synthetic phenotype
true
Two silent mutations show an altered phenotype when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794.
MI:0269
Death phenotype observed on cells carrying combination of two independently silent mutations.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (lethal FBcv:0000351)
MI:0219
event
IEV:0002691
synthetic lethal
true
Death phenotype observed on cells carrying combination of two independently silent mutations.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (lethal FBcv:0000351)
MI:0219
Two silent mutations show altered growth effect when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0273
event
IEV:0002692
synthetic growth effect
true
Two silent mutations show altered growth effect when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0273
Two silent mutations show a conditional synthetic lethal phenotype when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (lethal FBcv:0000351)
MI:0270
event
IEV:0002693
conditional synthetic lethal
true
Two silent mutations show a conditional synthetic lethal phenotype when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (lethal FBcv:0000351)
MI:0270
Level of over/underexpression scales the 'extend' of a phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'expression level alteration' MI:0803.
MI:0267
event
IEV:0002694
suppression scalable
true
Level of over/underexpression scales the 'extend' of a phenotype.
OBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'expression level alteration' MI:0803.
MI:0267
Two silent mutations show a nutrition sensitive lethal phenotype when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description.
MI:0600
event
IEV:0002695
conditional synthetic lethal nutrition-sensitivity
true
Two silent mutations show a nutrition sensitive lethal phenotype when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description.
MI:0600
Two silent mutations show a temperature sensitive lethal phenotype when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (FBcv:0000310 'temperature conditional')
MI:0271
event
IEV:0002696
conditional synthetic lethal temperature-sensitivity
true
Two silent mutations show a temperature sensitive lethal phenotype when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (FBcv:0000310 'temperature conditional')
MI:0271
Two silent mutations show growth defect when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0274
event
IEV:0002697
synthetic growth defect
true
Two silent mutations show growth defect when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0274
Two silent mutations show growth increase when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0275
event
IEV:0002698
synthetic growth increase
true
Two silent mutations show growth increase when they co-occur on the same cell.
OBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')
MI:0275
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
MeSH:D009421
event
IEV:0002699
Nervous System Malformation
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
MeSH:D009421
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure.
MeSH:D009436
event
IEV:0002700
Neural Tube Defect
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure.
MeSH:D009436
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
MeSH:D009422
event
IEV:0002701
Nervous System Disease
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
MeSH:D009422
Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA.
MeSH:D016135
PubMed:15555669
event
IEV:0002702
Spinal Dysraphism
Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA.
MeSH:D016135
IMR:0100454
PubMed:15731347
UniProt:Q9Y6R4
event
IEV:0002703
Phosphorylation of MKK4 by MEKK4 in cytosol
The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form.
GO:0016331
event
IEV:0002704
Morphogenesis of embryonic epithelium
The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form.
GO:0016331
The morphogenesis of an embryonic epithelium into a tube-shaped structure.
GO:0001838
event
IEV:0002705
Embryonic epithelial tube formation
The morphogenesis of an embryonic epithelium into a tube-shaped structure.
GO:0001838
The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium is a sheet of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
GO:0002009
event
IEV:0002706
Morphogenesis of an epithelium
The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium is a sheet of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
GO:0002009
The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
GO:0001841
neural tube morphogenesis
neurulation
event
IEV:0002707
Neural tube formation
The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
GO:0001841
neurulation
GO:0001841
The last step in the formation of the neural tube, where the paired neural folds are brought together at the dorsal midline.
GO:0001843
event
IEV:0002708
Neural tube closure
The last step in the formation of the neural tube, where the paired neural folds are brought together at the dorsal midline.
GO:0001843
The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
GO:0001839
event
IEV:0002709
Neural plate morphogenesis
The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
GO:0001839
The origin and formation of nervous tissue.
GO:0007399
neurite formation
neurite growth
event
IEV:0002710
Nervous system development
The origin and formation of nervous tissue.
GO:0007399
neurite formation
GO:0007399
neurite growth
GO:0007399
The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
GO:0035239
event
IEV:0002711
Tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
GO:0035239
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
GO:0048513
development of an organ
organogenesis
event
IEV:0002712
Organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
GO:0048513
development of an organ
GO:0048513
organogenesis
GO:0048513
The process whose specific outcome is the progression of a tube over time, from its intial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
GO:0035295
event
IEV:0002713
Tube development
The process whose specific outcome is the progression of a tube over time, from its intial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
GO:0035295
event
IEV:0002714
Toll-like receptor signaling pathway (through JNK cascade)
IMR:0100222
IMR:0100539
event
IEV:0002715
Binding of ECSIT and MEKK1 in cytosol
IMR:0100427
IMR:0100539
event
IEV:0002716
Binding of TRAF6 and ECSIT in cytosol
IMR:0000095
IMR:0000340
event
IEV:0002717
Binding of cytokine receptor and Grb2 in cytosol
IMR:0000276
IMR:0100733
event
IEV:0002718
Dephosphorylation of STAT5 by SHP-2 in cytosol
IMR:0000223
IMR:0000377
event
IEV:0002719
Phosphorylation of STAT3 dimer by serine kinase in cytosol and/or nucleus
The reaction direction shown, that is, A + B <==> C + D versus C + D <==> A + B, is in accordance with the direction of the reaction within a pathway.
This reaction occurs spontaneously -- no enzyme is required.
event
IEV:0002720
nonenzymatic reaction
The reaction direction shown, that is, A + B <==> C + D versus C + D <==> A + B, is in accordance with the direction of the reaction within a pathway.
This reaction occurs spontaneously -- no enzyme is required.
EcoCyc:
Terms aiming to represent biochemical reactions referring to their resulting product modifications.
MI:0414
event
IEV:0002721
enzymatic reaction
Terms aiming to represent biochemical reactions referring to their resulting product modifications.
MI:0414
EC:1.1.1.1
IMR:0200030
IMR:0200248
IMR:0200521
KEGG:C00069
KEGG:C00071
KEGG:R07326
event
IEV:0002722
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+( EC:1.1.1.1 )
Alcohol + NAD+ = Aldehyde + NADH + H+( EC:1.1.1.1 )
EC:1.1.1.184
IMR:0200030
IMR:0200067
IMR:0200463
KEGG:C01450
KEGG:C01612
KEGG:R03557
event
IEV:0002723
Secondary alcohol + NADP+ = Ketone + NADPH + H+( EC:1.1.1.184 )
EC:1.1.1.21
IMR:0200030
IMR:0200067
IMR:0200463
KEGG:C00717
KEGG:C01370
KEGG:R02820
event
IEV:0002724
Alditol + NADP+ = Aldose + NADPH + H+( EC:1.1.1.21 )
EC:1.1.1.35
IMR:0200030
IMR:0200248
IMR:0200521
KEGG:C00264
KEGG:C00640
KEGG:R01778
event
IEV:0002725
(3S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+( EC:1.1.1.35 )
EC:1.14.11.2
IMR:0200119
IMR:0200217
IMR:0200324
IMR:0200480
KEGG:C01078
KEGG:C04398
KEGG:R03219
event
IEV:0002726
procollagen L-proline + 2-Oxo-glutaric acid + O2 = procollagen trans-4-hydroxy-L-proline + Succinic acid + CO2( EC:1.14.11.2 )
EC:1.14.14.1
IMR:0200217
IMR:0200357
IMR:0200450
IMR:0200519
KEGG:C01335
KEGG:C01371
KEGG:R04122
event
IEV:0002727
Alkane + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein + H2O( EC:1.14.14.1 )
EC:1.17.4.1
IMR:0200108
IMR:0200133
IMR:0200357
KEGG:C03723
KEGG:C04232
KEGG:R04294
event
IEV:0002728
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin( EC:1.17.4.1 )
EC:1.2.1.3
IMR:0200030
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:C00060
KEGG:C00071
KEGG:R00538
event
IEV:0002729
Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
EC:1.2.1.5
IMR:0200030
IMR:0200067
IMR:0200357
IMR:0200463
KEGG:C00060
KEGG:C00071
KEGG:R00634
event
IEV:0002730
Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
EC:1.2.3.1
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:C00060
KEGG:C00071
KEGG:R00635
event
IEV:0002731
Aldehyde + H2O + O2 = Carboxylate + H2O2( EC:1.2.3.1 )
EC:1.3.99.3
IMR:0200065
IMR:0200224
IMR:0200300
KEGG:C00605
KEGG:R00392
event
IEV:0002732
Acyl-CoA + Acceptor = 2,3-dehydroacyl-CoA + Reduced acceptor( EC:1.3.99.3 )
EC:1.4.3.3
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:C00161
KEGG:C00405
KEGG:R01340
event
IEV:0002733
D-amino acid + H2O + O2 = 2-oxo acid + NH3 + H2O2( EC:1.4.3.3 )
EC:1.4.3.4
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:C00071
KEGG:C00375
KEGG:R01853
event
IEV:0002734
Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:1.4.3.21
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:C00071
KEGG:C00375
KEGG:R01853
event
IEV:0002735
Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
EC:1.8.1.4
IMR:0200030
IMR:0200248
IMR:0200521
KEGG:C16237
KEGG:C16832
KEGG:R08550
event
IEV:0002736
protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+( EC:1.8.1.4 )
EC:2.1.1.49
IMR:0200054
IMR:0200151
KEGG:C00706
KEGG:C02436
KEGG:R02808
event
IEV:0002737
S-adenosyl-L-methionine + Amine = S-adenosyl-L-homocysteine + Methylated amine( EC:2.1.1.49 )
true
EC:2.3.1.16
IMR:0200065
IMR:0200354
IMR:0200414
KEGG:C00264
KEGG:R00391
event
IEV:0002739
Acyl-CoA + Acetyl-CoA = CoA + 3-Oxoacyl-CoA( EC:2.3.1.16 )
true
EC:2.3.2.2
IMR:0001695
KEGG:C00012
KEGG:C03193
KEGG:C03363
KEGG:R04159
event
IEV:0002741
(5-L-glutamyl)-peptide + Amino acid = peptide + 5-L-glutamyl amino acid( EC:2.3.2.2 )
EC:2.4.2.1
IMR:0200102
KEGG:C00620
KEGG:C15586
KEGG:C15587
KEGG:R08368
event
IEV:0002742
general reaction
purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
EC:2.5.1.57
IMR:0200102
IMR:0200223
IMR:0200357
KEGG:C00686
KEGG:C01200
KEGG:R02769
event
IEV:0002743
Phosphoenol-pyruvic acid + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + Orthophosphate( EC:2.5.1.57 )
EC:2.7.1.1
IMR:0001351
IMR:0001360
KEGG:C00738
KEGG:C02965
KEGG:R02848
event
IEV:0002744
ATP + D-hexose = ADP + D-hexose 6-phosphate( EC:2.7.1.1 )
EC:2.7.1.60
IMR:0001351
IMR:0001360
KEGG:C00625
KEGG:C00686
KEGG:R02650
event
IEV:0002745
ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate( EC:2.7.1.60 )
EC:2.7.1.74
IMR:0200005
IMR:0200390
IMR:0200499
KEGG:C00454
KEGG:R02321
event
IEV:0002746
Nucleoside triphosphate + deoxycytidine = Nucleoside diphosphate + dCMP( EC:2.7.1.74 )
EC:2.7.4.10
IMR:0001360
IMR:0200083
IMR:0200499
KEGG:C00454
KEGG:R00333
event
IEV:0002747
Nucleoside triphosphate + AMP = Nucleoside diphosphate + ADP( EC:2.7.4.10 )
EC:2.7.7.43
IMR:0200202
IMR:0200280
KEGG:C00591
KEGG:C01064
KEGG:R02599
event
IEV:0002748
CTP + N-acylneuraminate = Pyrophosphate + CMP-N-acylneuraminate( EC:2.7.7.43 )
EC:2.8.3.5
IMR:0200037
IMR:0200119
KEGG:C00264
KEGG:C01656
KEGG:R01780
event
IEV:0002749
Succinyl-CoA + 3-oxo acid = succinate + 3-oxoacyl-CoA( EC:2.8.3.5 )
EC:3.1.3.25
IMR:0200102
IMR:0200177
IMR:0200357
KEGG:C15585
KEGG:R07343
event
IEV:0002750
myo-inositol phosphate + H2O = myo-inositol + Orthophosphate( EC:3.1.3.25 )
EC:3.1.3.5
IMR:0200102
IMR:0200357
KEGG:C00911
KEGG:C02520
KEGG:R07297
event
IEV:0002751
5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
EC:3.1.4.17
IMR:0200357
KEGG:C01117
KEGG:C04212
KEGG:R03259
event
IEV:0002752
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate( EC:3.1.4.17 )
EC:3.2.1.23
event
IEV:0002753
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides( EC:3.2.1.23 )
EC:3.5.1.15
IMR:0200357
IMR:0200459
KEGG:C00060
KEGG:C02715
KEGG:R00546
event
IEV:0002754
N-acyl-L-aspartate + H2O = Carboxylate + L-Aspartic acid( EC:3.5.1.15 )
EC:3.6.1.19
IMR:0001349
IMR:0200280
IMR:0200357
IMR:0200499
KEGG:R01532
event
IEV:0002755
Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
EC:3.6.1.6
IMR:0001349
IMR:0200102
IMR:0200357
KEGG:C00454
KEGG:R00329
event
IEV:0002756
nucleoside diphosphate + H2O = nucleotide + Orthophosphate( EC:3.6.1.6 )
EC:3.6.1.7
IMR:0200102
IMR:0200357
KEGG:C00060
KEGG:C02133
KEGG:R00539
event
IEV:0002757
Acylphosphate + H2O = Carboxylate + phosphate( EC:3.6.1.7 )
EC:3.6.1.9
IMR:0200357
KEGG:C01910
KEGG:C02171
KEGG:R00056
event
IEV:0002758
dinucleotide + H2O = 2 mononucleotide( EC:3.6.1.9 )
EC:4.2.1.17
IMR:0200357
KEGG:C00640
KEGG:C00658
KEGG:R02685
event
IEV:0002759
(3S)-3-hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O( EC:4.2.1.17 )
EC:5.1.3.8
KEGG:C00625
KEGG:C03000
KEGG:R02652
event
IEV:0002760
N-acyl-D-glucosamine = N-acyl-D-mannosamine( EC:5.1.3.8 )
EC:3.4.13.20
event
IEV:0002761
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine( EC:3.4.13.20 )
EC:1.2.4.1
IMR:0200324
IMR:0200331
KEGG:C15972
KEGG:C16255
KEGG:R01699
event
IEV:0002762
pyruvate + [dihydrolipoyllysine-residue acetyltransferase]lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2( EC:1.2.4.1 )
Pyruvic acid + Enzyme N6-(lipoyl)lysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2( EC:1.2.4.1 )
EC:1.2.4.2
IMR:0200324
IMR:0200480
KEGG:C15972
KEGG:C16254
KEGG:R01700
event
IEV:0002763
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2( EC:1.2.4.2 )
2-Oxo-glutaric acid + Enzyme N6-(lipoyl)lysine = [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2( EC:1.2.4.2 )
EC:2.7.1.48
IMR:0001351
IMR:0001360
IMR:0200021
IMR:0200409
KEGG:R00964
KEGG:map00240
event
IEV:0002764
ATP + Uridine => ADP + UMP( EC:2.7.1.48 )
EC:2.7.6.1
IMR:0001351
IMR:0200060
IMR:0200083
IMR:0200179
KEGG:R01049
KEGG:map00030
KEGG:map00230
event
IEV:0002765
ATP + D-Ribose 5-phosphate = AMP + D-5-Phospho-ribosyl 1-diphosphate( EC:2.7.6.1 )
ATP + D-Ribose 5-phosphate = AMP + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.7.6.1 )
EC:2.6.1.19
IMR:0100119
IMR:0200438
IMR:0200480
IMR:0200520
KEGG:R00908
KEGG:map00410
KEGG:map00640
event
IEV:0002766
2-Oxo-glutaric acid + beta-Alanine = L-Glutamic acid + Malonate semialdehyde( EC:2.6.1.19 )
EC:2.1.4.1
IMR:0100118
IMR:0200342
IMR:0200413
IMR:0200428
KEGG:R00565
KEGG:map00260
KEGG:map00330
event
IEV:0002767
L-Arginine + Glycine = L-Ornithine + Guanidino-acetic acid( EC:2.1.4.1 )
EC:4.3.2.1
IMR:0200186
IMR:0200391
IMR:0200428
KEGG:R01086
KEGG:map00250
KEGG:map00330
event
IEV:0002768
L-Arginino-succinic acid = L-Arginine + Fumaric acid( EC:4.3.2.1 )
EC:2.7.1.15
IMR:0001351
IMR:0001360
IMR:0200060
IMR:0200130
KEGG:R01051
KEGG:map00030
event
IEV:0002769
ATP + D-Ribose => ADP + D-Ribose 5-phosphate( EC:2.7.1.15 )
EC:1.1.1.14
IMR:0200030
IMR:0200248
IMR:0200462
IMR:0200474
IMR:0200521
KEGG:R00875
KEGG:map00051
event
IEV:0002770
NAD+ + D-Sorbitol = NADH + D-Fructose( EC:1.1.1.14 )
NAD+ + D-Sorbitol = NADH + D-Fructose + H+( EC:1.1.1.14 )
EC:2.5.1.21
IMR:0200097
IMR:0200273
IMR:0200280
KEGG:R00702
KEGG:map00100
event
IEV:0002771
subsequently IEV:0003222
2 Farnesyl diphosphate => Presqualene diphosphate + Pyrophosphate( EC:2.5.1.21 )
EC:2.4.2.4
IMR:0200048
IMR:0200102
IMR:0200103
IMR:0200234
KEGG:R02484
KEGG:map00240
event
IEV:0002772
Deoxy-uridine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Uracil( EC:2.4.2.4 )
EC:1.14.13.30
IMR:0200030
IMR:0200067
IMR:0200217
IMR:0200323
IMR:0200357
IMR:0200376
IMR:0200463
KEGG:R03866
KEGG:map00590
event
IEV:0002773
NADPH + Leucotriene B4 + O2 => NADP+ + 20-OH-Leukotriene B4 + H2O( EC:1.14.13.30 )
NADPH + Leukotriene B4 + O2 + H+ => NADP+ + 20-OH-Leukotriene B4 + H2O( EC:1.14.13.30 )
EC:1.1.1.28
IMR:0200030
IMR:0200248
IMR:0200313
IMR:0200331
IMR:0200521
KEGG:R00704
KEGG:map00620
event
IEV:0002774
NAD+ + (R)-Lactic acid = NADH + Pyruvic acid( EC:1.1.1.28 )
NAD+ + (R)-Lactic acid = NADH + Pyruvic acid + H+( EC:1.1.1.28 )
EC:1.3.99.3
IMR:0200441
IMR:0200484
KEGG:C04253
KEGG:C04570
KEGG:R04432
KEGG:map00640
event
IEV:0002775
Propanoyl-CoA + Acceptor = Propenoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
Propanoyl-CoA + Electron-transferring flavoprotein = Propenoyl-CoA + Reduced electron-transferring flavoprotein( EC:1.3.99.3 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200286
IMR:0200365
KEGG:R01857
KEGG:map00230
event
IEV:0002776
ATP + dGDP = ADP + dGTP( EC:2.7.4.6 )
EC:5.3.1.8
IMR:0200053
KEGG:C05345
KEGG:R01819
KEGG:map00051
KEGG:map00520
event
IEV:0002777
D-Mannose 6-phosphate = D-Fructose 6-phosphate( EC:5.3.1.8 )
D-Mannose 6-phosphate = beta-D-Fructose 6-phosphate( EC:5.3.1.8 )
EC:1.5.1.6
IMR:0200030
IMR:0200067
IMR:0200324
IMR:0200330
IMR:0200347
IMR:0200357
IMR:0200463
KEGG:R00941
KEGG:map00670
event
IEV:0002778
NADP+ + 10-Formyl-tetrahydro-folic acid + H2O => NADPH + L-Tetrahydro-folic acid + CO2( EC:1.5.1.6 )
NADP+ + 10-Formyl-tetrahydro-folic acid + H2O => NADPH + Tetrahydrofolate + CO2 + H+( EC:1.5.1.6 )
EC:1.2.1.3
IMR:0002041
IMR:0200030
IMR:0200248
IMR:0200357
IMR:0200421
IMR:0200521
KEGG:R05050
KEGG:map00330
event
IEV:0002779
NAD+ + N4-Acetyl-amino-butyraldehyde + H2O => NADH + N4-Acetyl-amino-butanoic acid( EC:1.2.1.3 )
NAD+ + N4-Acetylaminobutanal + H2O => NADH + N4-Acetyl-amino-butanoic acid + H+( EC:1.2.1.3 )
EC:3.1.3.5
IMR:0200102
IMR:0200357
IMR:0200495
IMR:0200505
KEGG:R01968
KEGG:map00230
event
IEV:0002780
dGMP + H2O => Deoxy-guanosine + Orthophosphate( EC:3.1.3.5 )
EC:2.7.1.153
IMR:0001350
IMR:0001351
IMR:0001352
IMR:0001360
KEGG:R04545
KEGG:map00562
KEGG:map04070
event
IEV:0002781
ATP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 3,4,5-triphosphate( EC:2.7.1.153 )
EC:2.1.1.6
IMR:0100114
IMR:0200054
IMR:0200080
IMR:0200151
KEGG:R02920
KEGG:map00350
event
IEV:0002782
S-Adenosyl-L-methionine + L-Adrenaline => S-Adenosyl-L-homocysteine + L-Metanephrine( EC:2.1.1.6 )
EC:6.4.1.3
IMR:0001351
IMR:0001360
IMR:0200016
IMR:0200102
IMR:0200484
KEGG:C00288
KEGG:R01859
KEGG:map00280
KEGG:map00640
event
IEV:0002783
ATP + Propanoyl-CoA + CO2 + H2O => ADP + (S)-Methyl-malonyl-CoA + Orthophosphate( EC:6.4.1.3 )
ATP + Propanoyl-CoA + HCO3- => ADP + (S)-Methyl-malonyl-CoA + Orthophosphate( EC:6.4.1.3 )
EC:2.6.1.1
IMR:0100119
IMR:0200170
IMR:0200402
IMR:0200480
KEGG:R02619
KEGG:map00270
event
IEV:0002784
2-Oxo-glutaric acid + L-Cysteine-sulfinic acid = L-Glutamic acid + 3-Sulfinyl-pyruvic acid( EC:2.6.1.1 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200199
IMR:0200206
KEGG:R00156
KEGG:map00240
event
IEV:0002786
ATP + UDP = ADP + UTP( EC:2.7.4.6 )
IEV:0003313
EC:2.3.1.12
IMR:0200354
IMR:0200414
KEGG:C15973
KEGG:C16255
KEGG:R02569
KEGG:map00010
KEGG:map00020
KEGG:map00620
Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine( EC:2.3.1.12 )
event
IEV:0002787
Acetyl-CoA + Dihydro-lipoamide = CoA + 6-S-Acetyl-dihydro-lipoamide( EC:2.3.1.12 )
Acetyl-CoA + Enzyme N6-(dihydrolipoyl)lysine = CoA + S-acetyldihydrolipoyllysine( EC:2.3.1.12 )
EC:3.7.1.3
IMR:0200251
IMR:0200301
IMR:0200312
IMR:0200357
KEGG:R00987
KEGG:map00380
event
IEV:0002788
L-Kynurenine + H2O => Anthranilic acid + L-Alanine( EC:3.7.1.3 )
EC:2.7.1.67
IMR:0001351
IMR:0001360
IMR:0200469
IMR:0200496
KEGG:R03361
KEGG:map00562
KEGG:map04070
event
IEV:0002789
ATP + 1-Phosphatidyl-1D-myo-inositol => ADP + 1-Phosphatidyl-1D-myo-inositol 4-phosphate( EC:2.7.1.67 )
EC:1.4.3.4
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200418
IMR:0200487
IMR:0200516
KEGG:R02613
KEGG:map00360
event
IEV:0002790
Phenyl-ethylamine + H2O + O2 => Phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:2.4.2.10
IMR:0200087
IMR:0200179
IMR:0200265
IMR:0200280
KEGG:R01870
KEGG:map00240
event
IEV:0002791
5'-Orotidylic acid + Pyrophosphate = Orotic acid + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.10 )
Orotidine 5'-phosphate + Pyrophosphate = Orotic acid + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.10 )
EC:1.1.1.40
IMR:0200030
IMR:0200067
IMR:0200278
IMR:0200324
IMR:0200331
IMR:0200463
KEGG:R00216
KEGG:map00620
KEGG:map00710
event
IEV:0002792
NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2( EC:1.1.1.40 )
NADP+ + (S)-Malic acid = NADPH + Pyruvic acid + CO2 + H+( EC:1.1.1.40 )
EC:1.2.1.5
IMR:0200030
IMR:0200193
IMR:0200248
IMR:0200357
IMR:0200418
IMR:0200521
KEGG:R02536
KEGG:map00360
KEGG:map00643
event
IEV:0002793
NAD+ + Phenyl-acetaldehyde + H2O = NADH + Phenyl-acetic acid( EC:1.2.1.5 )
NAD+ + Phenyl-acetaldehyde + H2O = NADH + Phenyl-acetic acid + H+( EC:1.2.1.5 )
EC:2.7.1.151
IMR:0001351
IMR:0001360
IMR:0100028
IMR:0200243
KEGG:R05800
KEGG:map00562
event
IEV:0002794
ATP + 1D-myo-inositol 1,4,5-trisphosphate => ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate( EC:2.7.1.151 )
EC:2.8.3.5
IMR:0200037
IMR:0200064
IMR:0200119
IMR:0200410
KEGG:R00410
KEGG:map00072
KEGG:map00280
KEGG:map00650
event
IEV:0002795
Succinyl-CoA + Acetoacetic acid = Succinic acid + Acetoacetyl-CoA( EC:2.8.3.5 )
EC:2.1.2.1
IMR:0100118
IMR:0200330
IMR:0200357
IMR:0200453
IMR:0200517
KEGG:R00945
KEGG:map00260
KEGG:map00670
event
IEV:0002796
L-Tetrahydro-folic acid + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O( EC:2.1.2.1 )
Tetrahydrofolate + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O( EC:2.1.2.1 )
EC:3.6.1.19
IMR:0200165
IMR:0200280
IMR:0200357
IMR:0200425
KEGG:R02720
KEGG:map00230
event
IEV:0002797
XTP + H2O => XMP + Pyrophosphate( EC:3.6.1.19 )
EC:2.1.2.3
IMR:0200284
IMR:0200330
IMR:0200347
IMR:0200452
KEGG:R04560
KEGG:map00230
KEGG:map00670
event
IEV:0002798
10-Formyl-tetrahydro-folic acid + 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole => L-Tetrahydro-folic acid + 5'-Phospho-ribosyl-4-carboxamido-5-formamido-imidazole( EC:2.1.2.3 )
10-Formyl-tetrahydro-folic acid + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide => Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide( EC:2.1.2.3 )
EC:1.8.1.4
IMR:0200030
IMR:0200248
IMR:0200336
IMR:0200367
IMR:0200521
KEGG:R03815
KEGG:map00260
event
IEV:0002799
NAD+ + Dihydro-lipoylprotein = NADH + Lipoylprotein( EC:1.8.1.4 )
NAD+ + Dihydro-lipoylprotein = NADH + Lipoylprotein + H+( EC:1.8.1.4 )
EC:6.4.1.1
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200331
IMR:0200339
KEGG:C00288
KEGG:R00344
KEGG:map00020
KEGG:map00620
event
IEV:0002800
ATP + Pyruvic acid + CO2 + H2O = ADP + Oxaloacetic acid + Orthophosphate( EC:6.4.1.1 )
ATP + Pyruvic acid + HCO3- = ADP + Oxaloacetic acid + Orthophosphate( EC:6.4.1.1 )
EC:4.2.1.3
IMR:0200271
IMR:0200357
IMR:0200473
KEGG:R01325
KEGG:map00020
KEGG:map00630
KEGG:map00720
event
IEV:0002801
Citric acid = cis-Aconitic acid + H2O( EC:4.2.1.3 )
EC:3.5.99.6
IMR:0200075
IMR:0200228
IMR:0200261
IMR:0200357
KEGG:R00765
KEGG:map00520
event
IEV:0002802
D-Glucosamine 6-phosphate + H2O = D-Fructose 6-phosphate + NH3( EC:3.5.99.6 )
EC:4.2.1.75
IMR:0200002
IMR:0200315
IMR:0200357
KEGG:R03165
KEGG:map00860
event
IEV:0002803
Hydroxy-methylbilane => Uroporphyrinogen III + H2O( EC:4.2.1.75 )
EC:1.2.4.2
IMR:0002042
IMR:0200324
IMR:0200378
IMR:0200480
KEGG:R00621
KEGG:map00020
event
IEV:0002804
subsequently IEV:0003057
TPP + 2-Oxo-glutaric acid = 3-Carboxy-1-hydroxypropyl-ThPP + CO2( EC:1.2.4.2 )
EC:2.1.1.6
IMR:0200026
IMR:0200054
IMR:0200151
IMR:0200269
KEGG:R03304
KEGG:map00350
event
IEV:0002805
S-Adenosyl-L-methionine + 3,4-Dihydroxy-phenyl-acetic acid => S-Adenosyl-L-homocysteine + Homovanillic acid( EC:2.1.1.6 )
EC:2.7.2.3
IMR:0001351
IMR:0001360
IMR:0200320
IMR:0200362
KEGG:R01512
KEGG:map00010
KEGG:map00710
event
IEV:0002806
ATP + D-Glycerate 3-phosphate = ADP + 1,3-Bisphospho-D-glyceric acid( EC:2.7.2.3 )
EC:2.1.3.2
IMR:0200077
IMR:0200102
IMR:0200109
IMR:0200459
KEGG:R01397
KEGG:map00240
KEGG:map00250
event
IEV:0002807
L-Aspartic acid + Carbamoyl phosphate => N-Carbamoyl-L-aspartic acid + Orthophosphate( EC:2.1.3.2 )
EC:5.3.99.4
IMR:0200253
IMR:0200281
KEGG:R02267
KEGG:map00590
event
IEV:0002808
Prostaglandin H2 = Prostaglandin I2( EC:5.3.99.4 )
EC:1.3.1.2
IMR:0200030
IMR:0200067
IMR:0200234
IMR:0200363
IMR:0200463
KEGG:R00978
KEGG:map00240
event
IEV:0002809
NADP+ + 5,6-Dihydro-uracil = NADPH + Uracil( EC:1.3.1.2 )
NADP+ + 5,6-Dihydro-uracil = NADPH + Uracil + H+( EC:1.3.1.2 )
EC:2.7.7.1
IMR:0001351
IMR:0200166
IMR:0200248
IMR:0200280
KEGG:R00137
KEGG:map00760
event
IEV:0002811
Nicotinamide D-ribonucleotide + ATP = NAD+ + Pyrophosphate( EC:2.7.7.1 )
EC:1.4.3.5
IMR:0200217
IMR:0200344
IMR:0200487
IMR:0200504
KEGG:R01711
KEGG:map00750
event
IEV:0002812
Pyridoxine + O2 => Pyridoxal + H2O2( EC:1.4.3.5 )
EC:1.1.1.1
IMR:0200030
IMR:0200248
IMR:0200289
IMR:0200442
IMR:0200521
KEGG:R04880
KEGG:map00350
event
IEV:0002813
NAD+ + 3,4-Dihydroxy-phenyl-ethyleneglycol = NADH + 3,4-Dihydroxy-mandelaldehyde( EC:1.1.1.1 )
NAD+ + 3,4-Dihydroxy-phenyl-ethyleneglycol = NADH + 3,4-Dihydroxy-mandelaldehyde + H+( EC:1.1.1.1 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200074
IMR:0200511
KEGG:R00722
KEGG:map00230
event
IEV:0002814
ATP + IDP = ADP + ITP( EC:2.7.4.6 )
EC:1.2.1.19
IMR:0100117
IMR:0200030
IMR:0200142
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R02549
KEGG:map00330
KEGG:map00410
event
IEV:0002815
NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid( EC:1.2.1.19 )
NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid + H+( EC:1.2.1.19 )
EC:2.1.2.5
IMR:0100119
IMR:0200211
IMR:0200330
IMR:0200443
KEGG:R02287
KEGG:map00340
KEGG:map00670
event
IEV:0002816
5-Formimino-tetrahydro-folic acid + L-Glutamic acid = L-Tetrahydro-folic acid + N-Formimino-L-glutamic acid( EC:2.1.2.5 )
5-Formimino-tetrahydro-folic acid + L-Glutamic acid = Tetrahydrofolate + N-Formimino-L-glutamic acid( EC:2.1.2.5 )
EC:2.6.1.39
IMR:0100119
IMR:0200011
IMR:0200322
IMR:0200480
KEGG:R01939
KEGG:map00300
KEGG:map00310
event
IEV:0002817
L-2-Amino-adipic acid + 2-Oxo-glutaric acid = 2-Oxo-adipic acid + L-Glutamic acid( EC:2.6.1.39 )
EC:1.2.1.24
IMR:0200030
IMR:0200119
IMR:0200248
IMR:0200357
IMR:0200454
IMR:0200521
KEGG:R00713
KEGG:map00250
KEGG:map00350
KEGG:map00650
event
IEV:0002818
NAD+ + Succinate semialdehyde + H2O = NADH + Succinic acid( EC:1.2.1.24 )
NAD+ + Succinate semialdehyde + H2O = NADH + Succinic acid + H+( EC:1.2.1.24 )
IMR:0200205
IMR:0200236
IMR:0200357
KEGG:R03314
KEGG:map00330
event
IEV:0002819
subsequently IEV:0003288
L-Glutamate 5-semialdehyde => (S)-1-Pyrroline-5-carboxylic acid + H2O( nonenzymatic )
EC:4.2.1.2
IMR:0200186
IMR:0200278
IMR:0200357
KEGG:R01082
KEGG:map00020
KEGG:map00720
event
IEV:0002820
(S)-Malic acid = Fumaric acid + H2O( EC:4.2.1.2 )
EC:1.1.1.30
IMR:0200030
IMR:0200064
IMR:0200218
IMR:0200248
IMR:0200521
KEGG:R01361
KEGG:map00072
KEGG:map00650
event
IEV:0002821
NAD+ + (R)-3-Hydroxy-butanoic acid = NADH + Acetoacetic acid( EC:1.1.1.30 )
NAD+ + (R)-3-Hydroxy-butanoic acid = NADH + Acetoacetic acid + H+( EC:1.1.1.30 )
EC:3.5.4.4
IMR:0100126
IMR:0200075
IMR:0200194
IMR:0200357
KEGG:R01560
KEGG:map00230
event
IEV:0002822
Adenosine + H2O => Inosine + NH3( EC:3.5.4.4 )
EC:2.3.1.29
IMR:0100118
IMR:0200354
IMR:0200414
KEGG:C03508
KEGG:R00371
KEGG:map00260
event
IEV:0002823
Acetyl-CoA + Glycine = CoA + L-2-Amino-3-oxo-butanoic acid( EC:2.3.1.29 )
EC:2.6.1.2
IMR:0100119
IMR:0200251
IMR:0200331
IMR:0200480
KEGG:R00258
KEGG:map00250
KEGG:map00710
event
IEV:0002824
L-Alanine + 2-Oxo-glutaric acid = Pyruvic acid + L-Glutamic acid( EC:2.6.1.2 )
EC:2.7.1.40
IMR:0001351
IMR:0001360
IMR:0200223
IMR:0200331
KEGG:R00200
KEGG:map00010
KEGG:map00230
KEGG:map00620
KEGG:map00710
event
IEV:0002825
ADP + Phosphoenol-pyruvic acid => ATP + Pyruvic acid( EC:2.7.1.40 )
EC:5.3.99.3
IMR:0200146
IMR:0200253
KEGG:R02265
KEGG:map00590
event
IEV:0002826
Prostaglandin H2 => Prostaglandin E2( EC:5.3.99.3 )
EC:1.1.1.35
IMR:0200030
IMR:0200248
IMR:0200395
IMR:0200410
IMR:0200521
KEGG:R01975
KEGG:map00071
KEGG:map00310
KEGG:map00380
KEGG:map00650
event
IEV:0002827
NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA( EC:1.1.1.35 )
NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA + H+( EC:1.1.1.35 )
EC:2.4.2.7
IMR:0200179
IMR:0200280
IMR:0200284
IMR:0200291
KEGG:R04378
KEGG:map00230
event
IEV:0002828
5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole + Pyrophosphate = 5-Amino-4-imidazole-carboxyamide + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Pyrophosphate = 5-Amino-4-imidazole-carboxyamide + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
EC:2.7.1.1
IMR:0001351
IMR:0001360
IMR:0200474
KEGG:C05345
KEGG:R00867
KEGG:map00051
event
IEV:0002829
ATP + D-Fructose => ADP + D-Fructose 6-phosphate( EC:2.7.1.1 )
ATP + D-Fructose => ADP + beta-D-Fructose 6-phosphate( EC:2.7.1.1 )
EC:3.5.2.2
IMR:0200276
IMR:0200357
IMR:0200363
KEGG:R02269
KEGG:map00240
KEGG:map00410
KEGG:map00770
event
IEV:0002830
5,6-Dihydro-uracil + H2O = Ureido-propanoic acid( EC:3.5.2.2 )
5,6-Dihydro-uracil + H2O = 3-Ureidopropionate( EC:3.5.2.2 )
EC:2.7.1.23
IMR:0001351
IMR:0001360
IMR:0200067
IMR:0200248
KEGG:R00104
KEGG:map00760
event
IEV:0002831
ATP + NAD+ => ADP + NADP+( EC:2.7.1.23 )
EC:1.3.3.3
IMR:0200217
IMR:0200258
IMR:0200324
IMR:0200357
IMR:0200523
KEGG:R03220
KEGG:map00860
event
IEV:0002832
Coproporphyrinogen III => Protoporphyrinogen IX + 2 CO2( EC:1.3.3.3 ):multi-step reaction
Coproporphyrinogen III + O2 => Protoporphyrinogen IX + 2 CO2 + 2 H2O( EC:1.3.3.3 )
EC:1.3.99.3
IMR:0200158
IMR:0200298
KEGG:C00016
KEGG:C01352
KEGG:R04095
KEGG:map00280
event
IEV:0002833
3-Methyl-butanoyl-CoA + Acceptor = 3-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
3-Methyl-butanoyl-CoA + FAD = 3-Methylbut-2-enoyl-CoA + FADH2( EC:1.3.99.3 )
EC:2.6.1.1
IMR:0100119
IMR:0200091
IMR:0200480
KEGG:C05946
KEGG:R05052
KEGG:map00330
event
IEV:0002834
2-Oxo-glutaric acid + L-erythro-4-Hydroxy-glutamic acid = L-Glutamic acid + D-4-Hydroxy-2-oxo-glutaric acid( EC:2.6.1.1 )
EC:4.2.1.11
IMR:0200223
IMR:0200357
IMR:0200405
KEGG:R00658
KEGG:map00010
event
IEV:0002835
D-Glycerate 2-phosphate = Phosphoenol-pyruvic acid + H2O( EC:4.2.1.11 )
EC:3.3.1.1
IMR:0100126
IMR:0200039
IMR:0200151
IMR:0200357
KEGG:R00192
KEGG:map00270
event
IEV:0002836
S-Adenosyl-L-homocysteine + H2O => Adenosine + L-Homocysteine( EC:3.3.1.1 )
EC:1.3.1.21
IMR:0200030
IMR:0200067
IMR:0200463
IMR:0200486
IMR:0200510
KEGG:R01456
KEGG:map00100
event
IEV:0002837
NADP+ + Cholesterol = NADPH + 7-Dehydro-cholesterol( EC:1.3.1.21 )
NADP+ + Cholesterol = NADPH + 7-Dehydro-cholesterol + H+( EC:1.3.1.21 )
EC:1.8.1.4
IMR:0200030
IMR:0200248
IMR:0200521
KEGG:C15972
KEGG:C15973
KEGG:R07618
KEGG:map00010
KEGG:map00020
KEGG:map00280
KEGG:map00620
event
IEV:0002838
NAD+ + Dihydro-lipoamide = NADH + Lipoamide( EC:1.8.1.4 )
NAD+ + Enzyme N6-(dihydrolipoyl)lysine = NADH + Enzyme N6-(lipoyl)lysine + H+( EC:1.8.1.4 )
EC:3.5.3.4
IMR:0200093
IMR:0200111
IMR:0200357
IMR:0200437
KEGG:R02422
KEGG:map00230
event
IEV:0002839
Allantoic acid + H2O => Ureido-glycolic acid + Urea( EC:3.5.3.4 )
Allantoic acid + H2O => (-)-Ureidoglycolate + Urea( EC:3.5.3.4 )
EC:2.7.7.12
IMR:0200190
IMR:0200227
IMR:0200283
IMR:0200304
KEGG:R00955
KEGG:map00052
KEGG:map00520
event
IEV:0002840
UDP-D-glucose + D-Galactose 1-phosphate = D-Glucose 1-phosphate + UDP-D-galactose( EC:2.7.7.12 )
UDP-D-glucose + alpha-D-Galactose 1-phosphate = D-Glucose 1-phosphate + UDP-D-galactose( EC:2.7.7.12 )
EC:3.1.3.25
IMR:0200102
IMR:0200177
IMR:0200357
IMR:0200419
KEGG:R01186
KEGG:map00562
KEGG:map04070
event
IEV:0002841
1D-myo-Inositol 4-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
EC:2.6.1.1
IMR:0200007
IMR:0200467
IMR:0200480
KEGG:C00302
KEGG:R00896
KEGG:map00270
event
IEV:0002842
2-Oxo-glutaric acid + L-Cysteine = L-Glutamic acid + 3-Mercapto-pyruvic acid( EC:2.6.1.1 )
2-Oxo-glutaric acid + L-Cysteine = DL-Glutamic acid + 3-Mercapto-pyruvic acid( EC:2.6.1.1 )
EC:1.1.1.35
IMR:0200030
IMR:0200207
IMR:0200248
IMR:0200288
IMR:0200521
KEGG:R04203
KEGG:map00280
event
IEV:0002843
NAD+ + (S)-3-Hydroxy-2-methyl-butanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA( EC:1.1.1.35 )
NAD+ + (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA + H+( EC:1.1.1.35 )
EC:1.3.99.7
IMR:0200121
IMR:0200224
IMR:0200256
IMR:0200300
IMR:0200324
KEGG:R02488
KEGG:map00310
KEGG:map00380
event
IEV:0002844
Glutaryl-CoA + Acceptor => Crotonoyl-CoA + CO2 + Reduced acceptor( EC:1.3.99.7 )
EC:2.7.4.9
IMR:0001351
IMR:0001360
IMR:0200187
IMR:0200338
KEGG:R02094
KEGG:map00240
event
IEV:0002845
ATP + dTMP = ADP + dTDP( EC:2.7.4.9 )
EC:2.2.1.1
IMR:0200058
IMR:0200060
IMR:0200141
IMR:0200169
KEGG:R01641
KEGG:map00030
KEGG:map00710
event
IEV:0002846
D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Ribose 5-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
EC:2.6.1.1
IMR:0100119
IMR:0200397
IMR:0200417
IMR:0200480
KEGG:R02433
KEGG:map00270
event
IEV:0002847
2-Oxo-glutaric acid + L-Cysteic acid = L-Glutamic acid + 3-Sulfo-pyruvic acid( EC:2.6.1.1 )
EC:1.2.1.5
IMR:0200030
IMR:0200114
IMR:0200248
IMR:0200325
IMR:0200357
IMR:0200521
KEGG:R04996
KEGG:map00340
event
IEV:0002848
NAD+ + 3-Methyl-imidazole acetaldehyde + H2O = NADH + 3-Methyl-imidazole-acetic acid( EC:1.2.1.5 )
NAD+ + Methylimidazole acetaldehyde + H2O = NADH + Methylimidazoleacetic acid + H+( EC:1.2.1.5 )
EC:3.5.2.2
IMR:0200132
IMR:0200343
IMR:0200357
KEGG:R03055
KEGG:map00240
event
IEV:0002849
5,6-Dihydro-thymine + H2O = 3-Ureido-2-methyl-propanoic acid( EC:3.5.2.2 )
5,6-Dihydro-thymine + H2O = 3-Ureidoisobutyrate( EC:3.5.2.2 )
EC:1.1.1.35
IMR:0200030
IMR:0200248
IMR:0200297
IMR:0200385
IMR:0200521
KEGG:R05066
KEGG:map00280
event
IEV:0002850
NAD+ + (S)-3-Hydroxy-2-methyl-propanoic acid = NADH + (S)-Methyl-malonate semialdehyde( EC:1.1.1.35 )
NAD+ + (S)-3-Hydroxyisobutyrate = NADH + (S)-Methyl-malonate semialdehyde + H+( EC:1.1.1.35 )
EC:1.1.1.47
IMR:0200030
IMR:0200067
IMR:0200242
IMR:0200463
KEGG:C00221
KEGG:R01521
KEGG:map00030
event
IEV:0002851
NADP+ + D-Glucose = NADPH + D-Glucono-1,5-lactone( EC:1.1.1.47 )
NADP+ + beta-D-Glucose = NADPH + D-Glucono-1,5-lactone + H+( EC:1.1.1.47 )
EC:1.3.1.2
IMR:0200030
IMR:0200036
IMR:0200067
IMR:0200343
IMR:0200463
KEGG:R01415
KEGG:map00240
event
IEV:0002852
NADP+ + 5,6-Dihydro-thymine = NADPH + Thymine( EC:1.3.1.2 )
NADP+ + 5,6-Dihydro-thymine = NADPH + Thymine + H+( EC:1.3.1.2 )
EC:5.4.2.1
IMR:0200320
IMR:0200405
KEGG:R01518
KEGG:map00010
event
IEV:0002853
D-Glycerate 2-phosphate = D-Glycerate 3-phosphate( EC:5.4.2.1 )
EC:4.1.1.32
IMR:0001354
IMR:0001357
IMR:0200223
IMR:0200324
IMR:0200339
KEGG:R00431
KEGG:map00010
KEGG:map00020
KEGG:map00620
event
IEV:0002854
GTP + Oxaloacetic acid = GDP + Phosphoenol-pyruvic acid + CO2( EC:4.1.1.32 )
EC:5.3.1.6
IMR:0200060
IMR:0200061
KEGG:R01056
KEGG:map00030
KEGG:map00710
event
IEV:0002855
D-Ribose 5-phosphate = D-Ribulose 5-phosphate( EC:5.3.1.6 )
EC:5.1.99.1
IMR:0200016
IMR:0200515
KEGG:R02765
KEGG:map00280
KEGG:map00640
event
IEV:0002856
(R)-Methyl-malonyl-CoA = (S)-Methyl-malonyl-CoA( EC:5.1.99.1 )
EC:5.3.99.5
IMR:0200253
IMR:0200489
KEGG:R02268
KEGG:map00590
event
IEV:0002857
Prostaglandin H2 => Thromboxane A2( EC:5.3.99.5 )
EC:1.2.1.3
IMR:0200030
IMR:0200070
IMR:0200168
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R03283
KEGG:map00310
event
IEV:0002858
NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid( EC:1.2.1.3 )
NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid + H+( EC:1.2.1.3 )
EC:5.2.1.2
IMR:0200245
IMR:0200507
KEGG:R03181
KEGG:map00350
KEGG:map00643
event
IEV:0002859
4-Maleyl-acetoacetic acid => 4-Fumaryl-acetoacetic acid( EC:5.2.1.2 )
EC:2.4.2.1
IMR:0200025
IMR:0200102
IMR:0200479
KEGG:C00620
KEGG:R02294
KEGG:map00760
event
IEV:0002860
N-Ribosyl-nicotinamide + Orthophosphate = Nicotinamide + D-Ribose 1-phosphate( EC:2.4.2.1 )
EC:6.3.1.2
IMR:0001351
IMR:0001360
IMR:0100119
IMR:0200075
IMR:0200102
IMR:0200448
KEGG:R00253
KEGG:map00250
KEGG:map00330
KEGG:map00910
event
IEV:0002861
ATP + L-Glutamic acid + NH3 = ADP + L-Glutamine + Orthophosphate( EC:6.3.1.2 )
EC:2.1.1.13
IMR:0200039
IMR:0200330
IMR:0200408
IMR:0200488
KEGG:R00946
KEGG:map00270
KEGG:map00670
event
IEV:0002862
5-Methyl-tetrahydro-folic acid + L-Homocysteine => L-Tetrahydro-folic acid + L-Methionine( EC:2.1.1.13 )
5-Methyl-tetrahydro-folic acid + L-Homocysteine => Tetrahydrofolate + L-Methionine( EC:2.1.1.13 )
EC:6.1.1.10
IMR:0001351
IMR:0200034
IMR:0200083
IMR:0200280
IMR:0200355
IMR:0200488
KEGG:R03659
KEGG:map00970
event
IEV:0002863
ATP + L-Methionine + tRNA(Met) => AMP + L-Methionyl-tRNA(Met) + Pyrophosphate( EC:6.1.1.10 )
EC:2.4.2.7
IMR:0200083
IMR:0200179
IMR:0200280
IMR:0200350
KEGG:R00190
KEGG:map00230
event
IEV:0002864
AMP + Pyrophosphate = Adenine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
AMP + Pyrophosphate = Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
EC:4.3.1.17
IMR:0200075
IMR:0200331
IMR:0200453
KEGG:R00220
KEGG:map00260
event
IEV:0002865
L-Serine => Pyruvic acid + NH3( EC:4.3.1.17 )
EC:1.5.1.34
IMR:0200030
IMR:0200045
IMR:0200067
IMR:0200209
IMR:0200463
KEGG:R01794
KEGG:map00790
event
IEV:0002866
NADPH + 6,7-Dihydro-biopterin => NADP+ + 5,6,7,8-Tetrahydro-biopterin( EC:1.5.1.34 )
NADPH + 6,7-Dihydro-biopterin + H+ => NADP+ + Tetrahydrobiopterin( EC:1.5.1.34 )
EC:2.7.4.8
IMR:0001351
IMR:0001360
IMR:0200365
IMR:0200505
KEGG:R02090
KEGG:map00230
event
IEV:0002867
ATP + dGMP = ADP + dGDP( EC:2.7.4.8 )
EC:1.14.14.1
IMR:0100069
IMR:0200041
IMR:0200217
IMR:0200357
IMR:0200450
IMR:0200519
KEGG:R03629
KEGG:map00380
event
IEV:0002868
Melatonin + O2 + Reduced flavoprotein => 6-Hydroxy-melatonin + H2O + Oxidized flavoprotein( EC:1.14.14.1 )
EC:2.4.2.8
IMR:0200173
IMR:0200179
IMR:0200221
IMR:0200280
KEGG:R01132
KEGG:map00230
event
IEV:0002869
IMP + Pyrophosphate = Hypoxanthine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
IMP + Pyrophosphate = Hypoxanthine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
EC:1.13.11.5
IMR:0200217
IMR:0200245
IMR:0200254
KEGG:R02519
KEGG:map00350
KEGG:map00643
event
IEV:0002870
2,5-Dihydroxy-phenyl-acetic acid + O2 => 4-Maleyl-acetoacetic acid( EC:1.13.11.5 )
EC:1.5.1.3
IMR:0200030
IMR:0200067
IMR:0200185
IMR:0200356
IMR:0200463
KEGG:R02236
KEGG:map00670
KEGG:map00790
event
IEV:0002871
NADPH + Folic acid => NADP+ + 7,8-Dihydro-folic acid( EC:1.5.1.3 )
NADPH + Folic acid + H+ => NADP+ + 7,8-Dihydro-folic acid( EC:1.5.1.3 )
EC:4.2.1.17
IMR:0200200
IMR:0200357
IMR:0200441
KEGG:R03045
KEGG:map00410
KEGG:map00640
event
IEV:0002872
3-Hydroxy-propanoyl-CoA = Propenoyl-CoA + H2O( EC:4.2.1.17 )
EC:2.5.1.29
IMR:0200097
IMR:0200280
IMR:0200287
IMR:0200316
KEGG:R02061
KEGG:map00900
event
IEV:0002873
Farnesyl diphosphate + Isopentenyl diphosphate = Geranyl-geranyl diphosphate + Pyrophosphate( EC:2.5.1.29 )
EC:1.1.1.27
IMR:0200030
IMR:0200248
IMR:0200270
IMR:0200331
IMR:0200521
KEGG:R00703
KEGG:map00010
KEGG:map00620
event
IEV:0002874
NAD+ + (S)-Lactic acid = NADH + Pyruvic acid( EC:1.1.1.27 )
NAD+ + (S)-Lactic acid = NADH + Pyruvic acid + H+( EC:1.1.1.27 )
EC:5.3.3.2
IMR:0200094
IMR:0200287
KEGG:R01123
KEGG:map00900
event
IEV:0002875
Dimethylallyl diphosphate = Isopentenyl diphosphate( EC:5.3.3.2 )
EC:3.5.4.3
IMR:0200075
IMR:0200319
IMR:0200357
IMR:0200439
KEGG:R01676
KEGG:map00230
event
IEV:0002876
Guanine + H2O => Xanthine + NH3( EC:3.5.4.3 )
EC:3.6.1.5
IMR:0200074
IMR:0200102
IMR:0200357
IMR:0200511
KEGG:R00719
KEGG:map00230
event
IEV:0002877
ITP + H2O => IDP + Orthophosphate( EC:3.6.1.5 )
EC:2.6.1.16
IMR:0100119
IMR:0200228
IMR:0200261
IMR:0200448
KEGG:R00768
KEGG:map00250
KEGG:map00520
event
IEV:0002878
L-Glutamine + D-Fructose 6-phosphate = L-Glutamic acid + D-Glucosamine 6-phosphate( EC:2.6.1.16 )
EC:2.7.4.14
IMR:0001351
IMR:0001360
IMR:0200206
IMR:0200409
KEGG:R00158
KEGG:map00240
event
IEV:0002879
ATP + UMP = ADP + UDP( EC:2.7.4.14 )
EC:2.4.2.8
IMR:0200165
IMR:0200179
IMR:0200280
IMR:0200439
KEGG:R02142
KEGG:map00230
event
IEV:0002880
XMP + Pyrophosphate = Xanthine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
XMP + Pyrophosphate = Xanthine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
EC:3.1.3.46
IMR:0200102
IMR:0200263
IMR:0200357
KEGG:C05345
KEGG:R02731
KEGG:map00051
event
IEV:0002881
D-Fructose 2,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.46 )
D-Fructose 2,6-bisphosphate + H2O => beta-D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.46 )
EC:1.3.3.1
IMR:0200217
IMR:0200265
IMR:0200393
IMR:0200487
KEGG:R01867
KEGG:map00240
event
IEV:0002882
(S)-Dihydro-orotic acid + O2 = Orotic acid + H2O2( EC:1.3.3.1 )
EC:2.7.1.15
IMR:0001351
IMR:0001360
IMR:0200147
IMR:0200449
KEGG:R02750
KEGG:map00030
event
IEV:0002883
ATP + 2-Deoxy-D-ribose => ADP + 2-Deoxy-D-ribose 5-phosphate( EC:2.7.1.15 )
EC:1.3.99.3
IMR:0200164
IMR:0200174
IMR:0200224
IMR:0200300
KEGG:R02661
KEGG:map00280
event
IEV:0002884
2-Methyl-propanoyl-CoA + Acceptor = 2-Methylprop-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
EC:2.1.1.45
IMR:0200008
IMR:0200185
IMR:0200187
IMR:0200517
KEGG:R02101
KEGG:map00240
KEGG:map00670
event
IEV:0002885
dUMP + 5,10-Methylene-tetrahydro-folic acid => dTMP + 7,8-Dihydro-folic acid( EC:2.1.1.45 )
EC:3.1.3.5
IMR:0200102
IMR:0200166
IMR:0200357
IMR:0200479
KEGG:R02323
KEGG:map00760
event
IEV:0002886
Nicotinamide D-ribonucleotide + H2O => N-Ribosyl-nicotinamide + Orthophosphate( EC:3.1.3.5 )
EC:1.14.16.4
IMR:0200045
IMR:0200112
IMR:0200209
IMR:0200217
IMR:0200307
IMR:0200357
KEGG:R01814
KEGG:map00380
event
IEV:0002887
L-Tryptophan + Tetrahydrobiopterin + O2 => 5-Hydroxy-L-tryptophan + 6,7-Dihydro-biopterin + H2O( EC:1.14.16.4 )
EC:2.4.2.7
IMR:0200179
IMR:0200280
IMR:0200292
IMR:0200319
KEGG:R01229
KEGG:map00230
event
IEV:0002888
GMP + Pyrophosphate = Guanine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
GMP + Pyrophosphate = Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
EC:2.7.4.3
IMR:0001351
IMR:0001360
IMR:0200160
IMR:0200237
KEGG:R01547
KEGG:map00230
event
IEV:0002889
ATP + dAMP = ADP + dADP( EC:2.7.4.3 )
EC:3.5.4.9
IMR:0200030
IMR:0200159
IMR:0200347
IMR:0200357
KEGG:R01655
KEGG:map00630
KEGG:map00670
event
IEV:0002890
5,10-Methenyl-tetrahydro-folic acid + H2O = 10-Formyl-tetrahydro-folic acid( EC:3.5.4.9 )
5,10-Methenyl-tetrahydro-folic acid + H2O = 10-Formyl-tetrahydro-folic acid + H+( EC:3.5.4.9 )
EC:4.2.1.17
IMR:0200121
IMR:0200357
IMR:0200395
KEGG:R03026
KEGG:map00071
KEGG:map00310
KEGG:map00380
KEGG:map00632
KEGG:map00650
event
IEV:0002892
(S)-3-Hydroxy-butanoyl-CoA = Crotonoyl-CoA + H2O( EC:4.2.1.17 )
EC:2.3.3.1
IMR:0200339
IMR:0200354
IMR:0200357
IMR:0200414
IMR:0200473
KEGG:R00351
KEGG:map00020
KEGG:map00630
event
IEV:0002893
Acetyl-CoA + Oxaloacetic acid + H2O => CoA + Citric acid( EC:2.3.3.1 )
EC:4.4.1.1
IMR:0200075
IMR:0200127
IMR:0200220
IMR:0200357
IMR:0200467
KEGG:R01001
KEGG:map00260
KEGG:map00270
KEGG:map00910
event
IEV:0002894
L-Cystathionine + H2O => L-Cysteine + 2-Oxo-butanoic acid + NH3( EC:4.4.1.1 )
EC:3.6.1.13
IMR:0200060
IMR:0200083
IMR:0200134
IMR:0200357
KEGG:R01054
KEGG:map00230
event
IEV:0002895
ADP-5-ribose + H2O => AMP + D-Ribose 5-phosphate( EC:3.6.1.13 )
ADP-ribose + H2O => AMP + D-Ribose 5-phosphate( EC:3.6.1.13 )
EC:6.1.1.14
IMR:0001351
IMR:0100118
IMR:0200083
IMR:0200215
IMR:0200280
IMR:0200433
KEGG:R03654
KEGG:map00970
event
IEV:0002896
ATP + Glycine + tRNA(Gly) => AMP + Glycyl-tRNA(Gly) + Pyrophosphate( EC:6.1.1.14 )
EC:3.5.4.4
IMR:0200075
IMR:0200197
IMR:0200226
IMR:0200357
KEGG:R02556
KEGG:map00230
event
IEV:0002897
Deoxy-adenosine + H2O => Deoxy-inosine + NH3( EC:3.5.4.4 )
EC:6.3.5.2
IMR:0001351
IMR:0100119
IMR:0200083
IMR:0200165
IMR:0200280
IMR:0200292
IMR:0200357
IMR:0200448
KEGG:R01231
KEGG:map00230
event
IEV:0002898
ATP + XMP + L-Glutamine + H2O => AMP + GMP + L-Glutamic acid + Pyrophosphate( EC:6.3.5.2 )
EC:1.4.3.4
IMR:0100124
IMR:0200040
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:R02382
KEGG:map00350
event
IEV:0002899
Tyramine + H2O + O2 => 4-Hydroxy-phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:1.1.1.153
IMR:0200030
IMR:0200063
IMR:0200067
IMR:0200209
IMR:0200463
KEGG:R08208
event
IEV:0002900
2 NADPH + 6-Pyruvoyl-5,6,7,8-tetrahydro-pterin => 2 NADP+ + 5,6,7,8-Tetrahydro-biopterin( EC:1.1.1.153 ):multi-step reaction
2 NADPH + 6-Pyruvoyltetrahydropterin + 2 H+ => 2 NADP+ + Tetrahydrobiopterin( EC:1.1.1.153 )
EC:2.3.3.10
IMR:0200033
IMR:0200354
IMR:0200357
IMR:0200410
IMR:0200414
KEGG:R01978
KEGG:map00072
KEGG:map00280
KEGG:map00650
KEGG:map00900
event
IEV:0002901
(S)-3-Hydroxy-3-methyl-glutaryl-CoA + CoA => Acetyl-CoA + Acetoacetyl-CoA + H2O( EC:2.3.3.10 )
EC:1.11.1.6
IMR:0200030
IMR:0200217
IMR:0200381
IMR:0200400
IMR:0200487
KEGG:C00704
KEGG:R02670
KEGG:map00380
event
IEV:0002902
2 3-Hydroxy-anthranilic acid => Cinnavalininic acid( EC:1.11.1.6 ):
non-enzymatic
multi-step reaction
this reaction is hastened by superoxide dismutase (ec 1.15.1.1) and
catalase (ec 1.11.1.6)
2 3-Hydroxy-anthranilic acid + 4 O2 = Cinnavalininate + 2 O2.- + 2 H2O2 + 2 H+( EC:1.11.1.6 )
EC:1.4.4.2
IMR:0100118
IMR:0200324
IMR:0200336
IMR:0200377
KEGG:R03425
KEGG:map00260
event
IEV:0002903
Lipoylprotein + Glycine => S-Aminomethyl-dihydro-lipoylprotein + CO2( EC:1.4.4.2 )
EC:3.1.3.5
IMR:0200102
IMR:0200161
IMR:0200357
IMR:0200494
KEGG:R00511
KEGG:map00240
event
IEV:0002904
CMP + H2O => Cytidine + Orthophosphate( EC:3.1.3.5 )
IMR:0200192
IMR:0200357
IMR:0200460
KEGG:R04293
event
IEV:0002905
2-Amino-3-carboxy-muconate semialdehyde => 2,3-Pyridine-dicarboxylic acid + H2O( nonenzymatic )
EC:1.2.1.3
IMR:0200030
IMR:0200208
IMR:0200248
IMR:0200357
IMR:0200373
IMR:0200521
KEGG:R00710
KEGG:map00010
KEGG:map00620
event
IEV:0002906
NAD+ + Acetaldehyde + H2O = NADH + Acetic acid( EC:1.2.1.3 )
NAD+ + Acetaldehyde + H2O = NADH + Acetic acid + H+( EC:1.2.1.3 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200499
KEGG:C00454
KEGG:R00331
event
IEV:0002907
general reaction
ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
EC:3.1.3.67
IMR:0001350
IMR:0001352
IMR:0200102
IMR:0200357
KEGG:R04513
KEGG:map00562
KEGG:map04070
event
IEV:0002908
1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O => 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate + Orthophosphate ( EC:3.1.3.67 )
EC:4.1.2.13
IMR:0200058
IMR:0200100
KEGG:C05378
KEGG:R01070
KEGG:map00010
KEGG:map00030
KEGG:map00051
event
IEV:0002909
D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate( EC:4.1.2.13 )
beta-D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate( EC:4.1.2.13 )
IEV:0002740
EC:2.3.1.61
IMR:0200037
IMR:0200354
KEGG:C15973
KEGG:C16254
KEGG:R02570
KEGG:map00020
Succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine( EC:2.3.1.61 )
event
IEV:0002910
Succinyl-CoA + Dihydro-lipoamide = CoA + S-Succinyl-dihydro-lipoamide( EC:2.3.1.61 )
Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine = CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine( EC:2.3.1.61 )
EC:1.1.1.38
IMR:0200030
IMR:0200248
IMR:0200278
IMR:0200324
IMR:0200331
IMR:0200521
KEGG:R00214
KEGG:map00620
KEGG:map00710
event
IEV:0002911
NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2( EC:1.1.1.38 )
NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2 + H+( EC:1.1.1.38 )
EC:1.3.99.3
IMR:0200224
IMR:0200300
IMR:0200465
KEGG:C15980
KEGG:R03172
KEGG:map00280
event
IEV:0002912
2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
(S)-2-Methylbutanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
EC:6.1.1.7
IMR:0001351
IMR:0200083
IMR:0200095
IMR:0200244
IMR:0200251
IMR:0200280
KEGG:R03038
KEGG:map00970
event
IEV:0002913
ATP + L-Alanine + tRNA(Ala) => AMP + L-Alanyl-tRNA(Ala) + Pyrophosphate( EC:6.1.1.7 )
EC:4.1.1.45
IMR:0200192
IMR:0200324
IMR:0200424
KEGG:R04323
KEGG:map00380
event
IEV:0002914
2-Amino-3-carboxy-muconate semialdehyde => 2-Amino-muconate semialdehyde + CO2( EC:4.1.1.45 )
EC:4.3.1.17
IMR:0200090
IMR:0200357
IMR:0200453
KEGG:R00590
KEGG:map00270
event
IEV:0002915
L-Serine => 2-Amino-acrylic acid + H2O( EC:4.3.1.17 )
EC:4.1.1.28
IMR:0100123
IMR:0200112
IMR:0200324
KEGG:R02701
KEGG:map00380
event
IEV:0002917
5-Hydroxy-L-tryptophan => Serotonin + CO2( EC:4.1.1.28 )
EC:1.13.11.34
IMR:0200275
IMR:0200357
IMR:0200461
KEGG:R03058
KEGG:map00590
event
IEV:0002918
5-HPETE => Leucotriene A4 + H2O( EC:1.13.11.34 )
5(S)-HPETE => Leukotriene A4 + H2O( EC:1.13.11.34 )
EC:3.1.3.25
IMR:0200102
IMR:0200177
IMR:0200357
IMR:0200476
KEGG:R01185
KEGG:map00562
KEGG:map04070
event
IEV:0002919
1D-myo-Inositol 1-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
EC:2.6.1.13
IMR:0100119
IMR:0200205
IMR:0200342
IMR:0200480
KEGG:R00667
KEGG:map00330
event
IEV:0002920
2-Oxo-glutaric acid + N2-Succinyl-L-ornithine = L-Glutamic acid + N2-Succinyl-L-glutamate 5-semialdehyde( EC:2.6.1.13 )
2-Oxo-glutaric acid + L-Ornithine = L-Glutamic acid + L-Glutamate 5-semialdehyde( EC:2.6.1.13 )
EC:2.1.1.6
IMR:0200054
IMR:0200068
IMR:0200151
IMR:0200152
KEGG:R04887
KEGG:map00350
event
IEV:0002921
S-Adenosyl-L-methionine + 3,4-Dihydroxy-mandelic acid => S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxy-mandelic acid( EC:2.1.1.6 )
EC:4.3.2.2
IMR:0200083
IMR:0200115
IMR:0200186
KEGG:R01083
KEGG:map00230
KEGG:map00250
event
IEV:0002922
Adenylo-succinic acid = AMP + Fumaric acid( EC:4.3.2.2 )
EC:4.3.2.2
IMR:0200186
IMR:0200213
IMR:0200284
KEGG:R04559
KEGG:map00230
event
IEV:0002923
5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole = 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole + Fumaric acid( EC:4.3.2.2 )
5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole = 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Fumaric acid( EC:4.3.2.2 )
EC:3.7.1.3
IMR:0200066
IMR:0200251
IMR:0200357
IMR:0200400
KEGG:R02668
KEGG:map00380
event
IEV:0002924
3-Hydroxy-L-kynurenine + H2O => 3-Hydroxy-anthranilic acid + L-Alanine( EC:3.7.1.3 )
EC:2.7.4.10
IMR:0001360
IMR:0200083
IMR:0200199
IMR:0200206
KEGG:R00157
KEGG:map00240
event
IEV:0002925
UTP + AMP = UDP + ADP( EC:2.7.4.10 )
EC:1.13.11.33
IMR:0200212
IMR:0200217
IMR:0200351
KEGG:R01593
KEGG:map00590
event
IEV:0002926
Arachidonic acid + O2 => 15-HPETE( EC:1.13.11.33 )
Arachidonic acid + O2 => 15(S)-HPETE( EC:1.13.11.33 )
EC:3.1.3.36
IMR:0001350
IMR:0200102
IMR:0200357
IMR:0200496
KEGG:R04404
KEGG:map00562
KEGG:map04070
event
IEV:0002927
1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O => 1-Phosphatidyl-1D-myo-inositol 4 phosphate + Orthophosphate( EC:3.1.3.36 )
EC:1.1.1.37
IMR:0200030
IMR:0200248
IMR:0200278
IMR:0200339
IMR:0200521
KEGG:R00342
KEGG:map00020
KEGG:map00620
KEGG:map00630
KEGG:map00710
KEGG:map00720
event
IEV:0002928
NAD+ + (S)-Malic acid = NADH + Oxaloacetic acid( EC:1.1.1.37 )
NAD+ + (S)-Malic acid = NADH + Oxaloacetic acid + H+( EC:1.1.1.37 )
EC:2.7.1.74
IMR:0001351
IMR:0001360
IMR:0200005
IMR:0200390
KEGG:R01666
KEGG:map00240
event
IEV:0002929
ATP + Deoxy-cytidine => ADP + dCMP( EC:2.7.1.74 )
EC:2.1.1.5
IMR:0200039
IMR:0200047
IMR:0200233
IMR:0200488
KEGG:R02821
KEGG:map00260
KEGG:map00270
event
IEV:0002930
L-Homocysteine + Betaine => L-Methionine + N,N-Dimethyl-glycine( EC:2.1.1.5 )
EC:3.5.3.1
IMR:0200111
IMR:0200342
IMR:0200357
IMR:0200428
KEGG:R00551
KEGG:map00330
event
IEV:0002931
L-Arginine + H2O => L-Ornithine + Urea( EC:3.5.3.1 )
EC:5.3.1.9
KEGG:C01172
KEGG:C05345
KEGG:R03321
KEGG:map00010
event
IEV:0002932
D-Glucose 6-phosphate = D-Fructose 6-phosphate( EC:5.3.1.9 )
beta-D-Glucose 6-phosphate = beta-D-Fructose 6-phosphate( EC:5.3.1.9 )
EC:1.3.99.2
IMR:0200224
IMR:0200300
IMR:0200465
KEGG:C15980
KEGG:R03172
KEGG:map00280
event
IEV:0002933
2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
(S)-2-Methylbutanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
EC:1.5.1.9
IMR:0100119
IMR:0200030
IMR:0200155
IMR:0200248
IMR:0200294
IMR:0200357
IMR:0200521
KEGG:R02313
KEGG:map00310
event
IEV:0002934
NAD+ + L-Saccharopine + H2O = NADH + L-2-Amino-adipate 6-semialdehyde + L-Glutamic acid( EC:1.5.1.9 )
NAD+ + L-Saccharopine + H2O = NADH + L-2-Amino-adipate 6-semialdehyde + L-Glutamic acid + H+( EC:1.5.1.9 )
EC:1.14.99.7
IMR:0200030
IMR:0200067
IMR:0200217
IMR:0200357
IMR:0200463
IMR:0200481
IMR:0200509
KEGG:R02874
KEGG:map00100
event
IEV:0002935
Squalene + O2 + Reduced acceptor => (S)-2,3-Epoxy-squalene + H2O + Acceptor( EC:1.14.99.7 )
Squalene + O2 + NADPH + H+ => (S)-2,3-Epoxy-squalene + H2O + NADP+( EC:1.14.99.7 )
EC:4.6.1.2
IMR:0001354
IMR:0100025
IMR:0200280
KEGG:R00434
KEGG:map00230
event
IEV:0002936
GTP => 3',5'-Cyclic GMP + Pyrophosphate( EC:4.6.1.2 )
EC:5.4.2.2
IMR:0200060
KEGG:C00620
KEGG:R01057
KEGG:map00030
KEGG:map00230
event
IEV:0002937
D-Ribose 1-phosphate = D-Ribose 5-phosphate( EC:5.4.2.2 )
EC:1.13.99.1
IMR:0200015
IMR:0200177
IMR:0200217
IMR:0200357
KEGG:R01184
KEGG:map00053
KEGG:map00562
event
IEV:0002938
myo-Inositol + O2 => D-Glucuronic acid + H2O( EC:1.13.99.1 )
EC:4.1.2.-
IMR:0100118
IMR:0200070
IMR:0200493
KEGG:R03284
KEGG:map00310
event
IEV:0002939
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine => 4-Trimethyl-ammonio-butanal + Glycine( EC:2.1.2.1 )
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine => 4-Trimethyl-ammonio-butanal + Glycine( EC:4.1.2.- )
EC:2.7.4.14
IMR:0001351
IMR:0001360
IMR:0200005
IMR:0200078
KEGG:R01665
KEGG:map00240
event
IEV:0002940
ATP + dCMP = ADP + dCDP( EC:2.7.4.14 )
EC:2.4.2.4
IMR:0200048
IMR:0200102
IMR:0200173
IMR:0200197
KEGG:R02748
KEGG:map00230
event
IEV:0002941
Deoxy-inosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Hypoxanthine( EC:2.4.2.4 )
EC:6.2.1.5
IMR:0001351
IMR:0001360
IMR:0200037
IMR:0200102
IMR:0200119
IMR:0200354
KEGG:R00405
KEGG:map00020
KEGG:map00640
KEGG:map00720
event
IEV:0002942
CoA + ATP + Succinic acid = Succinyl-CoA + ADP + Orthophosphate( EC:6.2.1.5 )
EC:6.1.1.2
IMR:0001351
IMR:0200083
IMR:0200260
IMR:0200280
IMR:0200306
IMR:0200307
KEGG:R03664
KEGG:map00380
KEGG:map00970
event
IEV:0002943
ATP + L-Tryptophan + tRNA(Trp) => AMP + L-Tryptophanyl-tRNA(Trp) + Pyrophosphate( EC:6.1.1.2 )
EC:4.1.1.21
IMR:0200324
IMR:0200422
IMR:0200513
KEGG:R04209
KEGG:map00230
event
IEV:0002944
5'-Phospho-ribosyl-5-amino-imidazole-4-carboxylic acid = 5'-Phospho-ribosyl-5-amino-imidazole + CO2( EC:4.1.1.21 )
1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate = 5'-Phospho-ribosyl-5-amino-imidazole + CO2( EC:4.1.1.21 )
EC:2.3.1.65
IMR:0100120
IMR:0200004
IMR:0200138
IMR:0200354
KEGG:R03720
KEGG:map00120
KEGG:map00430
event
IEV:0002945
Choloyl-CoA + Taurine = CoA + Taurocholic acid( EC:2.3.1.65 )
EC:1.4.1.3
IMR:0100119
IMR:0200030
IMR:0200075
IMR:0200248
IMR:0200357
IMR:0200480
IMR:0200521
KEGG:R00243
KEGG:map00250
KEGG:map00330
KEGG:map00471
KEGG:map00910
event
IEV:0002946
NAD+ + L-Glutamic acid + H2O = NADH + 2-Oxo-glutaric acid + NH3( EC:1.4.1.3 )
NAD+ + L-Glutamic acid + H2O = NADH + 2-Oxo-glutaric acid + NH3 + H+( EC:1.4.1.3 )
EC:4.1.2.13
IMR:0200100
IMR:0200120
IMR:0200167
KEGG:R02568
KEGG:map00051
event
IEV:0002947
D-Fructose 1-phosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde( EC:4.1.2.13 )
EC:5.4.2.2
IMR:0200190
KEGG:C00668
KEGG:R00959
KEGG:map00010
KEGG:map00052
KEGG:map00500
KEGG:map00520
event
IEV:0002948
D-Glucose 1-phosphate = D-Glucose 6-phosphate( EC:5.4.2.2 )
D-Glucose 1-phosphate = alpha-D-Glucose 6-phosphate( EC:5.4.2.2 )
EC:1.2.1.5
IMR:0200030
IMR:0200152
IMR:0200171
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R04891
KEGG:map00350
event
IEV:0002949
NAD+ + 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + H2O = NADH + 3-Methoxy-4-hydroxy-mandelic acid( EC:1.2.1.5 )
NAD+ + 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + H2O = NADH + 3-Methoxy-4-hydroxy-mandelic acid + H+( EC:1.2.1.5 )
EC:3.1.3.57
IMR:0100698
IMR:0200102
IMR:0200357
IMR:0200419
KEGG:R03393
KEGG:map00562
KEGG:map04070
event
IEV:0002950
1D-myo-Inositol 1,4-bisphosphate + H2O => 1D-myo-Inositol 4-phosphate + Orthophosphate( EC:3.1.3.57 )
EC:2.6.1.13
IMR:0200205
IMR:0200342
KEGG:C00151
KEGG:C00161
KEGG:R01343
event
IEV:0002951
2-Oxo acid + L-Ornithine = L-Amino acid + L-Glutamate 5-semialdehyde( EC:2.6.1.13 )
EC:1.4.3.4
IMR:0200075
IMR:0200171
IMR:0200217
IMR:0200357
IMR:0200388
IMR:0200487
KEGG:R04893
KEGG:map00350
event
IEV:0002952
L-Normetanephrine + H2O + O2 => 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200202
IMR:0200468
KEGG:R00570
KEGG:map00240
event
IEV:0002953
ATP + CDP = ADP + CTP( EC:2.7.4.6 )
EC:4.2.1.18
IMR:0200033
IMR:0200069
IMR:0200357
KEGG:R02085
KEGG:map00280
event
IEV:0002954
(S)-3-Hydroxy-3-methyl-glutaryl-CoA = 3-Methyl-glutaconyl-CoA + H2O( EC:4.2.1.18 )
EC:3.7.1.2
IMR:0200064
IMR:0200186
IMR:0200357
IMR:0200507
KEGG:R01364
KEGG:map00350
KEGG:map00643
event
IEV:0002955
4-Fumaryl-acetoacetic acid + H2O => Fumaric acid + Acetoacetic acid( EC:3.7.1.2 )
EC:3.1.3.11
IMR:0200102
IMR:0200357
KEGG:C05345
KEGG:C05378
KEGG:R04780
KEGG:map00010
KEGG:map00030
KEGG:map00051
event
IEV:0002956
D-Fructose 1,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.11 )
beta-D-Fructose 1,6-bisphosphate + H2O => beta-D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.11 )
EC:5.1.3.8
IMR:0200282
IMR:0200374
KEGG:R01207
KEGG:map00520
event
IEV:0002957
N-Acetyl-D-glucosamine = N-Acetyl-D-mannosamine( EC:5.1.3.8 )
EC:3.6.1.5
IMR:0001357
IMR:0200102
IMR:0200292
IMR:0200357
KEGG:R00328
KEGG:map00230
event
IEV:0002958
GDP + H2O => GMP + Orthophosphate( EC:3.6.1.5 )
EC:3.6.1.6
IMR:0200102
IMR:0200221
IMR:0200357
IMR:0200511
KEGG:R00961
KEGG:map00230
event
IEV:0002959
IDP + H2O => IMP + Orthophosphate( EC:3.6.1.6 )
EC:2.7.7.4
IMR:0001351
IMR:0200032
IMR:0200232
IMR:0200280
KEGG:R00529
KEGG:map00230
event
IEV:0002960
ATP + Sulfuric acid => Adenosine-5'-phospho-sulfate + Pyrophosphate( EC:2.7.7.4 )
EC:2.7.7.23
IMR:0200199
IMR:0200247
IMR:0200280
KEGG:C04501
KEGG:R00416
KEGG:map00520
event
IEV:0002961
UTP + N-Acetyl-D-glucosamine 1-phosphate = Pyrophosphate + UDP-N-acetyl-D-glucosamine( EC:2.7.7.23 )
UTP + N-Acetyl-alpha-D-glucosamine 1-phosphate = Pyrophosphate + UDP-N-acetyl-D-glucosamine( EC:2.7.7.23 )
EC:2.3.1.9
IMR:0200354
IMR:0200410
IMR:0200414
KEGG:R00238
KEGG:map00071
KEGG:map00072
KEGG:map00280
KEGG:map00310
KEGG:map00380
KEGG:map00620
KEGG:map00632
KEGG:map00640
KEGG:map00650
KEGG:map00900
event
IEV:0002962
2 Acetyl-CoA = CoA + Acetoacetyl-CoA( EC:2.3.1.9 )
EC:4.1.1.9
IMR:0200324
IMR:0200414
IMR:0200464
KEGG:R00233
KEGG:map00410
KEGG:map00640
event
IEV:0002963
Malonyl-CoA = Acetyl-CoA + CO2( EC:4.1.1.9 )
EC:6.3.4.4
IMR:0001354
IMR:0001357
IMR:0200102
IMR:0200115
IMR:0200221
IMR:0200459
KEGG:R01135
KEGG:map00230
KEGG:map00250
event
IEV:0002964
GTP + IMP + L-Aspartic acid => GDP + Adenylo-succinic acid + Orthophosphate( EC:6.3.4.4 )
EC:1.17.4.1
IMR:0001360
IMR:0200108
IMR:0200133
IMR:0200237
IMR:0200357
KEGG:R02017
KEGG:map00230
event
IEV:0002965
ADP + Reduced thioredoxin => dADP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
EC:2.7.4.9
IMR:0001351
IMR:0001360
IMR:0200008
IMR:0200098
KEGG:R02098
KEGG:map00240
event
IEV:0002966
ATP + dUMP = ADP + dUDP( EC:2.7.4.9 )
EC:2.4.2.4
IMR:0200036
IMR:0200048
IMR:0200102
IMR:0200384
KEGG:R01570
KEGG:map00240
event
IEV:0002967
Thymidine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Thymine( EC:2.4.2.4 )
EC:1.13.11.34
IMR:0200212
IMR:0200217
IMR:0200275
KEGG:R01595
KEGG:map00590
event
IEV:0002968
Arachidonic acid + O2 => 5-HPETE( EC:1.13.11.34 ):subsequently IEV:0002918
Arachidonic acid + O2 => 5(S)-HPETE( EC:1.13.11.34 )
EC:3.6.1.19
IMR:0200074
IMR:0200221
IMR:0200280
IMR:0200357
KEGG:R00720
KEGG:map00230
event
IEV:0002969
ITP + H2O => IMP + Pyrophosphate( EC:3.6.1.19 )
EC:3.5.4.5
IMR:0200075
IMR:0200103
IMR:0200357
IMR:0200390
KEGG:R02485
KEGG:map00240
event
IEV:0002970
Deoxy-cytidine + H2O => Deoxy-uridine + NH3( EC:3.5.4.5 )
EC:3.5.1.6
IMR:0200075
IMR:0200276
IMR:0200324
IMR:0200357
IMR:0200438
KEGG:R00905
KEGG:map00240
KEGG:map00410
KEGG:map00770
event
IEV:0002971
Ureido-propanoic acid + H2O => beta-Alanine + CO2 + NH3( EC:3.5.1.6 )
3-Ureidopropionate + H2O => beta-Alanine + CO2 + NH3( EC:3.5.1.6 )
EC:2.7.1.52
IMR:0001351
IMR:0001360
IMR:0200101
IMR:0200303
KEGG:R03161
KEGG:map00051
KEGG:map00520
event
IEV:0002972
ATP + L-Fucose = ADP + L-Fucose 1-phosphate( EC:2.7.1.52 )
EC:2.4.2.19
IMR:0200179
IMR:0200262
IMR:0200280
IMR:0200324
IMR:0200460
KEGG:R03348
KEGG:map00760
event
IEV:0002973
D-5-Phospho-ribosyl 1-diphosphate + 2,3-Pyridine-dicarboxylic acid => Nicotinate D-ribonucleotide + Pyrophosphate + CO2( EC:2.4.2.19 )
5-Phospho-alpha-D-ribose 1-diphosphate + 2,3-Pyridine-dicarboxylic acid => Nicotinate D-ribonucleotide + Pyrophosphate + CO2( EC:2.4.2.19 )
EC:2.1.1.2
IMR:0200054
IMR:0200144
IMR:0200151
IMR:0200413
KEGG:R01883
KEGG:map00260
KEGG:map00330
event
IEV:0002974
S-Adenosyl-L-methionine + Guanidino-acetic acid => S-Adenosyl-L-homocysteine + Creatine( EC:2.1.1.2 )
EC:4.1.1.28
IMR:0200324
IMR:0200491
IMR:0200500
KEGG:R04909
KEGG:map00380
event
IEV:0002975
5-Hydroxy-kynurenine => 5-Hydroxy-kynurenamine + CO2( EC:4.1.1.28 )
EC:1.1.1.271
IMR:0200030
IMR:0200067
IMR:0200150
IMR:0200463
IMR:0200472
KEGG:R05692
KEGG:map00051
KEGG:map00520
event
IEV:0002976
NADP+ + GDP-L-fucose = NADPH + GDP-4-dehydro-6-deoxy-D-mannose( EC:1.1.1.271 )
NADP+ + GDP-L-fucose = NADPH + GDP-4-dehydro-6-deoxy-D-mannose + H+( EC:1.1.1.271 )
EC:1.5.1.8
IMR:0200030
IMR:0200067
IMR:0200140
IMR:0200155
IMR:0200357
IMR:0200463
IMR:0200480
KEGG:R00716
KEGG:map00300
KEGG:map00310
event
IEV:0002977
NADPH + L-Lysine + 2-Oxo-glutaric acid => NADP+ + L-Saccharopine + H2O( EC:1.5.1.8 )
NADPH + L-Lysine + 2-Oxo-glutaric acid + H+ => NADP+ + L-Saccharopine + H2O( EC:1.5.1.8 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200073
IMR:0200122
KEGG:R03530
KEGG:map00230
event
IEV:0002978
ATP + dIDP = ADP + dITP( EC:2.7.4.6 )
EC:3.1.3.9
IMR:0200102
IMR:0200357
KEGG:C00267
KEGG:C00668
KEGG:R01788
KEGG:map00010
KEGG:map00052
KEGG:map00500
event
IEV:0002979
D-Glucose 6-phosphate + H2O => D-Glucose + Orthophosphate( EC:3.1.3.9 )
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate( EC:3.1.3.9 )
EC:4.1.1.29
IMR:0200305
IMR:0200324
IMR:0200402
KEGG:R02466
KEGG:map00430
event
IEV:0002980
L-Cysteine-sulfinic acid => Hypotaurine + CO2( EC:4.1.1.29 )
EC:2.6.1.51
IMR:0200251
IMR:0200331
IMR:0200453
IMR:0200470
KEGG:R00585
KEGG:map00260
event
IEV:0002981
L-Serine + Pyruvic acid = Hydroxy-pyruvic acid + L-Alanine( EC:2.6.1.51 )
EC:1.4.3.5
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200382
IMR:0200487
IMR:0200504
KEGG:R01710
KEGG:map00750
event
IEV:0002982
Pyridoxamine + O2 + H2O => Pyridoxal + H2O2 + NH3( EC:1.4.3.5 )
EC:5.4.2.8
IMR:0200053
IMR:0200327
KEGG:R01818
KEGG:map00051
KEGG:map00520
event
IEV:0002983
D-Mannose 1-phosphate = D-Mannose 6-phosphate( EC:5.4.2.8 )
EC:2.7.7.1
IMR:0001351
IMR:0200082
IMR:0200262
IMR:0200280
KEGG:R03005
KEGG:map00760
event
IEV:0002984
Nicotinate D-ribonucleotide + ATP = Deamido-NAD+ + Pyrophosphate( EC:2.7.7.1 )
EC:1.1.1.95
IMR:0200030
IMR:0200248
IMR:0200320
IMR:0200329
IMR:0200521
KEGG:R01513
KEGG:map00260
event
IEV:0002985
NAD+ + D-Glycerate 3-phosphate = NADH + 3-Phospho-hydroxy-pyruvic acid( EC:1.1.1.95 )
NAD+ + D-Glycerate 3-phosphate = NADH + 3-Phospho-hydroxy-pyruvic acid + H+( EC:1.1.1.95 )
EC:2.5.1.56
IMR:0200020
IMR:0200102
IMR:0200223
IMR:0200282
IMR:0200357
KEGG:R01804
KEGG:map00520
event
IEV:0002986
N-Acetyl-D-mannosamine + Phosphoenol-pyruvic acid + H2O => N-Acetyl-neuraminic acid + Orthophosphate( EC:2.5.1.56 )
EC:1.2.1.3
IMR:0200030
IMR:0200052
IMR:0200248
IMR:0200353
IMR:0200357
IMR:0200521
KEGG:R04903
KEGG:map00380
event
IEV:0002987
NAD+ + 5-Hydroxy-indole-acetaldehyde + H2O => NADH + 5-Hydroxy-indole-acetic acid( EC:1.2.1.3 )
NAD+ + 5-Hydroxy-indole-acetaldehyde + H2O => NADH + 5-Hydroxy-indole-acetic acid + H+( EC:1.2.1.3 )
EC:2.4.2.1
IMR:0100126
IMR:0200102
IMR:0200350
KEGG:C00620
KEGG:R01561
KEGG:map00230
event
IEV:0002988
Adenosine + Orthophosphate = Adenine + D-Ribose 1-phosphate( EC:2.4.2.1 )
EC:2.2.1.1
IMR:0200012
IMR:0200058
IMR:0200169
KEGG:C05345
KEGG:R01830
KEGG:map00030
event
IEV:0002989
D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
beta-D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
EC:2.7.7.22
IMR:0001357
IMR:0200102
IMR:0200327
IMR:0200451
KEGG:R00883
KEGG:map00051
KEGG:map00520
event
IEV:0002990
GDP + D-Mannose 1-phosphate => GDP-D-mannose + Orthophosphate( EC:2.7.7.22 )
EC:1.2.1.3
IMR:0200030
IMR:0200248
IMR:0200357
IMR:0200371
IMR:0200503
IMR:0200521
KEGG:R02940
KEGG:map00640
event
IEV:0002991
NAD+ + 2-Propyn-1-al + H2O = NADH + Propiolic acid( EC:1.2.1.3 )
NAD+ + 2-Propyn-1-al + H2O = NADH + Propiolic acid + H+( EC:1.2.1.3 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200084
IMR:0200338
KEGG:R02093
KEGG:map00240
event
IEV:0002992
ATP + dTDP = ADP + dTTP( EC:2.7.4.6 )
EC:3.5.4.12
IMR:0200005
IMR:0200008
IMR:0200075
IMR:0200357
KEGG:R01663
KEGG:map00240
event
IEV:0002993
dCMP + H2O => dUMP + NH3( EC:3.5.4.12 )
EC:4.2.1.3
IMR:0200023
IMR:0200271
IMR:0200357
KEGG:R01900
KEGG:map00020
KEGG:map00630
KEGG:map00720
event
IEV:0002994
cis-Aconitic acid + H2O = Isocitric acid( EC:4.2.1.3 )
EC:2.6.1.19
IMR:0100117
IMR:0100119
IMR:0200454
IMR:0200480
KEGG:R01648
KEGG:map00250
KEGG:map00650
event
IEV:0002995
2-Oxo-glutaric acid + 4-Amino-butanoic acid = L-Glutamic acid + Succinate semialdehyde( EC:2.6.1.19 )
EC:6.1.1.19
IMR:0001351
IMR:0200072
IMR:0200083
IMR:0200280
IMR:0200366
IMR:0200428
KEGG:R03646
KEGG:map00970
event
IEV:0002996
ATP + L-Arginine + tRNA(Arg) => AMP + L-Arginyl-tRNA(Arg) + Pyrophosphate( EC:6.1.1.19 )
EC:2.6.1.44
IMR:0100118
IMR:0200184
IMR:0200251
IMR:0200331
KEGG:R00369
KEGG:map00250
event
IEV:0002997
L-Alanine + Glyoxylic acid = Pyruvic acid + Glycine( EC:2.6.1.44 )
EC:2.6.1.42
IMR:0100119
IMR:0200088
IMR:0200480
IMR:0200501
KEGG:R01214
KEGG:map00280
KEGG:map00290
KEGG:map00770
KEGG:map00966
event
IEV:0002998
2-Oxo-glutaric acid + L-Valine = L-Glutamic acid + 3-Methyl-2-oxo-butanoic acid( EC:2.6.1.42 )
EC:4.4.1.5
IMR:0002043
IMR:0200318
IMR:0200471
KEGG:R02530
KEGG:map00620
event
IEV:0002999
(R)-S-Lactoyl-glutathione = Glutathione + Methyl-glyoxal( EC:4.4.1.5 )
EC:3.5.1.2
IMR:0100119
IMR:0200075
IMR:0200357
IMR:0200448
KEGG:R00256
KEGG:map00250
KEGG:map00330
KEGG:map00471
KEGG:map00910
event
IEV:0003000
L-Glutamine + H2O = L-Glutamic acid + NH3( EC:3.5.1.2 )
EC:1.5.1.12
IMR:0200030
IMR:0200091
IMR:0200248
IMR:0200340
IMR:0200357
IMR:0200521
KEGG:R05051
KEGG:map00330
event
IEV:0003001
NAD+ + L-4-Hydroxy-glutamate semialdehyde + H2O => NADH + L-erythro-4-Hydroxy-glutamic acid( EC:1.5.1.12 )
NAD+ + L-4-Hydroxy-glutamate semialdehyde + H2O => NADH + L-erythro-4-Hydroxy-glutamic acid + H+( EC:1.5.1.12 )
EC:6.1.1.16
IMR:0001351
IMR:0200014
IMR:0200044
IMR:0200083
IMR:0200280
IMR:0200467
KEGG:R03650
KEGG:map00970
event
IEV:0003002
ATP + L-Cysteine + tRNA(Cys) => AMP + L-Cysteinyl-tRNA(Cys) + Pyrophosphate( EC:6.1.1.16 )
EC:4.2.1.17
IMR:0200298
IMR:0200357
KEGG:C05998
KEGG:R04137
KEGG:map00280
event
IEV:0003003
3-Hydroxy-isopentyl-CoA = 3-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
3-Hydroxyisovaleryl-CoA = 3-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
EC:2.6.1.1
IMR:0100119
IMR:0200339
IMR:0200459
IMR:0200480
KEGG:R00355
KEGG:map00250
KEGG:map00710
event
IEV:0003004
2-Oxo-glutaric acid + L-Aspartic acid = L-Glutamic acid + Oxaloacetic acid( EC:2.6.1.1 )
EC:3.1.4.17
IMR:0100024
IMR:0200083
IMR:0200357
KEGG:R00191
KEGG:map00230
event
IEV:0003005
3',5'-Cyclic AMP + H2O => AMP( EC:3.1.4.17 )
EC:1.14.11.2
IMR:0200119
IMR:0200183
IMR:0200217
IMR:0200299
IMR:0200324
IMR:0200480
KEGG:R01252
KEGG:map00330
event
IEV:0003006
L-Proline + 2-Oxo-glutaric acid + O2 => trans-4-Hydroxy-L-proline + Succinic acid + CO2( EC:1.14.11.2 )
EC:2.7.7.30
IMR:0001354
IMR:0200101
IMR:0200150
IMR:0200280
KEGG:R01951
KEGG:map00051
KEGG:map00520
event
IEV:0003007
GTP + L-Fucose 1-phosphate = GDP-L-fucose + Pyrophosphate( EC:2.7.7.30 )
EC:2.7.4.3
IMR:0001351
IMR:0001360
IMR:0200083
KEGG:R00127
KEGG:map00230
event
IEV:0003008
ATP + AMP = 2 ADP( EC:2.7.4.3 )
EC:1.1.1.188
IMR:0200030
IMR:0200046
IMR:0200067
IMR:0200457
IMR:0200463
KEGG:R02799
KEGG:map00590
event
IEV:0003009
NADPH + Prostaglandin D2 => NADP+ + 11-epi-Prostaglandin F2alpha( EC:1.1.1.188 )
NADPH + Prostaglandin D2 + H+ => NADP+ + 11-epi-Prostaglandin F2alpha( EC:1.1.1.188 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200078
IMR:0200235
KEGG:R02326
KEGG:map00240
event
IEV:0003010
ATP + dCDP = ADP + dCTP( EC:2.7.4.6 )
EC:2.4.2.1
IMR:0200102
IMR:0200173
IMR:0200194
KEGG:C00620
KEGG:R01863
KEGG:map00230
event
IEV:0003011
Inosine + Orthophosphate = Hypoxanthine + D-Ribose 1-phosphate( EC:2.4.2.1 )
EC:2.2.1.2
IMR:0200012
IMR:0200058
IMR:0200141
KEGG:C05345
KEGG:R01827
KEGG:map00030
event
IEV:0003012
D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Fructose 6-phosphate( EC:2.2.1.2 )
D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + beta-D-Fructose 6-phosphate( EC:2.2.1.2 )
EC:4.1.1.28
IMR:0100124
IMR:0200240
IMR:0200324
KEGG:R00736
KEGG:map00350
KEGG:map00950
event
IEV:0003013
L-Tyrosine => Tyramine + CO2( EC:4.1.1.28 )
EC:3.5.4.5
IMR:0200021
IMR:0200075
IMR:0200161
IMR:0200357
KEGG:R01878
KEGG:map00240
event
IEV:0003014
Cytidine + H2O => Uridine + NH3( EC:3.5.4.5 )
EC:3.6.1.5
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200357
KEGG:R00086
KEGG:map00230
event
IEV:0003015
ATP + H2O => ADP + Orthophosphate( EC:3.6.1.5 )
EC:2.4.2.12
IMR:0200025
IMR:0200166
IMR:0200179
IMR:0200280
KEGG:R01271
KEGG:map00760
event
IEV:0003016
Nicotinamide D-ribonucleotide + Pyrophosphate = Nicotinamide + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.12 )
Nicotinamide D-ribonucleotide + Pyrophosphate = Nicotinamide + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.12 )
EC:2.7.1.149
IMR:0001350
IMR:0001351
IMR:0001360
IMR:0200149
KEGG:R05803
KEGG:map00562
KEGG:map04070
event
IEV:0003017
ATP + 1-Phosphatidyl-1D-myo-inositol 5-phosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate( EC:2.7.1.149 )
EC:2.4.2.1
IMR:0200048
IMR:0200102
IMR:0200226
IMR:0200350
KEGG:R02557
KEGG:map00230
event
IEV:0003018
Deoxy-adenosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Adenine( EC:2.4.2.4 )
Deoxy-adenosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Adenine( EC:2.4.2.1 )
EC:4.1.3.4
IMR:0200033
IMR:0200064
IMR:0200414
KEGG:R01360
KEGG:map00072
KEGG:map00280
KEGG:map00650
event
IEV:0003019
(S)-3-Hydroxy-3-methyl-glutaryl-CoA = Acetyl-CoA + Acetoacetic acid( EC:4.1.3.4 )
EC:2.1.1.28
IMR:0100114
IMR:0100115
IMR:0200054
IMR:0200151
KEGG:R02533
KEGG:map00350
event
IEV:0003020
S-Adenosyl-L-methionine + L-Noradrenaline => S-Adenosyl-L-homocysteine + L-Adrenaline( EC:2.1.1.28 )
EC:1.2.1.27
IMR:0200030
IMR:0200248
IMR:0200297
IMR:0200324
IMR:0200354
IMR:0200484
IMR:0200521
KEGG:R00935
KEGG:map00280
KEGG:map00640
event
IEV:0003021
NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2( EC:1.2.1.27 )
NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2 + H+( EC:1.2.1.27 )
IEV:0003030
EC:1.5.1.2
IMR:0200030
IMR:0200225
IMR:0200248
IMR:0200299
IMR:0200521
KEGG:R03291
KEGG:map00330
event
IEV:0003022
IEV:0003022: NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid = NAD+ + trans-4-Hydroxy-L-proline( EC:1.5.1.2 )
--------------------
IEV:0003030: NAD+ + trans-4-Hydroxy-L-proline => NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid( EC:1.5.1.12 )
NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + H+ = NAD+ + trans-4-Hydroxy-L-proline( EC:1.5.1.2 )
EC:2.6.1.65
IMR:0100119
IMR:0200143
IMR:0200214
IMR:0200480
KEGG:R04029
KEGG:map00310
event
IEV:0003023
N6-Acetyl-L-lysine + 2-Oxo-glutaric acid = 6-Acetamido-2-oxo-hexanoic acid + L-Glutamic acid( EC:2.6.1.39 )
N6-Acetyl-L-lysine + 2-Oxo-glutaric acid = 6-Acetamido-2-oxo-hexanoic acid + L-Glutamic acid( EC:2.6.1.65 )
EC:2.4.2.4
IMR:0200048
IMR:0200102
IMR:0200319
IMR:0200495
KEGG:R01969
KEGG:map00230
event
IEV:0003024
Deoxy-guanosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Guanine( EC:2.4.2.4 )
EC:2.4.2.1
IMR:0200102
IMR:0200426
IMR:0200439
KEGG:C00620
KEGG:R02297
KEGG:map00230
event
IEV:0003025
Xanthosine + Orthophosphate = Xanthine + D-Ribose 1-phosphate( EC:2.4.2.1 )
EC:2.7.1.21
IMR:0001351
IMR:0001360
IMR:0200008
IMR:0200103
KEGG:R02099
KEGG:map00240
event
IEV:0003026
ATP + Deoxy-uridine => ADP + dUMP( EC:2.7.1.21 )
EC:6.2.1.4
IMR:0001354
IMR:0001357
IMR:0200037
IMR:0200102
IMR:0200119
IMR:0200354
KEGG:R00432
KEGG:map00020
KEGG:map00640
event
IEV:0003027
CoA + GTP + Succinic acid = Succinyl-CoA + GDP + Orthophosphate( EC:6.2.1.4 )
EC:2.7.1.1
IMR:0001351
IMR:0001360
IMR:0200228
IMR:0200485
KEGG:R01961
KEGG:map00520
event
IEV:0003028
ATP + D-Glucosamine => ADP + D-Glucosamine 6-phosphate( EC:2.7.1.1 )
EC:2.7.1.48
IMR:0001351
IMR:0001360
IMR:0200161
IMR:0200494
KEGG:R00513
KEGG:map00240
event
IEV:0003029
ATP + Cytidine => ADP + CMP( EC:2.7.1.48 )
true
EC:3.1.3.5
IMR:0200102
IMR:0200292
IMR:0200357
IMR:0200445
KEGG:R01227
KEGG:map00230
event
IEV:0003031
GMP + H2O => Guanosine + Orthophosphate( EC:3.1.3.5 )
EC:1.1.1.34
IMR:0200030
IMR:0200033
IMR:0200067
IMR:0200118
IMR:0200354
IMR:0200463
KEGG:R02082
KEGG:map00900
event
IEV:0003032
2 NADPH + (S)-3-Hydroxy-3-methyl-glutaryl-CoA => 2 NADP+ + CoA + (R)-Mevalonic acid( EC:1.1.1.34 )
2 NADPH + (S)-3-Hydroxy-3-methyl-glutaryl-CoA + 2 H+ => 2 NADP+ + CoA + (R)-Mevalonic acid( EC:1.1.1.34 )
EC:5.1.3.2
IMR:0200227
IMR:0200283
KEGG:R00291
KEGG:map00052
KEGG:map00520
event
IEV:0003033
UDP-D-glucose = UDP-D-galactose( EC:5.1.3.2 )
EC:1.17.4.1
IMR:0001357
IMR:0200108
IMR:0200133
IMR:0200357
IMR:0200365
KEGG:R02019
KEGG:map00230
event
IEV:0003034
GDP + Reduced thioredoxin => dGDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
EC:6.1.1.22
IMR:0001351
IMR:0200083
IMR:0200105
IMR:0200113
IMR:0200280
IMR:0200328
KEGG:R03648
KEGG:map00970
event
IEV:0003035
ATP + L-Asparagine + tRNA(Asn) => AMP + L-Asparaginyl-tRNA(Asn) + Pyrophosphate( EC:6.1.1.22 )
EC:5.3.1.1
IMR:0200058
IMR:0200100
KEGG:R01015
KEGG:map00010
KEGG:map00051
KEGG:map00562
KEGG:map00710
event
IEV:0003036
D-Glyceraldehyde 3-phosphate = Dihydroxy-acetone phosphate( EC:5.3.1.1 )
EC:3.2.1.23
IMR:0200123
IMR:0200277
IMR:0200357
KEGG:C00267
KEGG:R01678
KEGG:map00052
event
IEV:0003037
Lactose + H2O => D-Glucose + D-Galactose( EC:3.2.1.23 )
Lactose + H2O => alpha-D-Glucose + D-Galactose( EC:3.2.1.23 )
EC:6.1.1.18
IMR:0001351
IMR:0200083
IMR:0200117
IMR:0200280
IMR:0200448
IMR:0200506
KEGG:R03652
KEGG:map00970
event
IEV:0003038
ATP + L-Glutamine + tRNA(Gln) => AMP + Glutaminyl-tRNA + Pyrophosphate( EC:6.1.1.18 )
EC:6.4.1.4
IMR:0001351
IMR:0001360
IMR:0200069
IMR:0200102
IMR:0200298
KEGG:C00288
KEGG:R04138
KEGG:map00280
event
IEV:0003039
ATP + 3-Methylbut-2-enoyl-CoA + CO2 + H2O => ADP + 3-Methyl-glutaconyl-CoA + Orthophosphate( EC:6.4.1.4 )
ATP + 3-Methylbut-2-enoyl-CoA + HCO3- => ADP + 3-Methyl-glutaconyl-CoA + Orthophosphate( EC:6.4.1.4 )
EC:6.3.3.1
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200398
IMR:0200513
KEGG:R04208
KEGG:map00230
event
IEV:0003040
ATP + 5'-Phospho-ribosyl-N-formyl-glycinamidine => ADP + 5'-Phospho-ribosyl-5-amino-imidazole + Orthophosphate( EC:6.3.3.1 )
EC:2.6.1.42
IMR:0100119
IMR:0200370
IMR:0200480
IMR:0200492
KEGG:R01090
KEGG:map00280
KEGG:map00290
KEGG:map00966
event
IEV:0003041
2-Oxo-glutaric acid + L-Leucine = L-Glutamic acid + 4-Methyl-2-oxo-pentanoic acid( EC:2.6.1.42 )
EC:3.6.1.19
IMR:0200199
IMR:0200280
IMR:0200357
IMR:0200409
KEGG:R00662
KEGG:map00240
event
IEV:0003042
UTP + H2O => UMP + Pyrophosphate( EC:3.6.1.19 )
EC:4.1.1.33
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200287
IMR:0200324
IMR:0200431
KEGG:R01121
KEGG:map00900
event
IEV:0003043
ATP + (R)-Mevalonic acid 5-diphosphate => ADP + Isopentenyl diphosphate + Orthophosphate + CO2( EC:4.1.1.33 )
ATP + (R)-5-Diphosphomevalonate => ADP + Isopentenyl diphosphate + Orthophosphate + CO2( EC:4.1.1.33 )
EC:2.1.1.8
IMR:0100125
IMR:0200054
IMR:0200151
IMR:0200401
KEGG:R02155
KEGG:map00340
event
IEV:0003044
S-Adenosyl-L-methionine + Histamine => S-Adenosyl-L-homocysteine + N-Methyl-histamine( EC:2.1.1.8 )
EC:2.6.1.5
IMR:0100119
IMR:0200274
IMR:0200380
IMR:0200480
KEGG:R00694
KEGG:map00360
KEGG:map00400
event
IEV:0003045
2-Oxo-glutaric acid + L-Phenylalanine = L-Glutamic acid + Phenyl-pyruvic acid( EC:2.6.1.5 )
EC:2.1.1.4
IMR:0200052
IMR:0200054
IMR:0200151
IMR:0200201
KEGG:R04905
KEGG:map00380
event
IEV:0003046
S-Adenosyl-L-methionine + 5-Hydroxy-indole-acetic acid => S-Adenosyl-L-homocysteine + 5-Methoxy-indole-acetic acid( EC:2.1.1.4 )
EC:1.4.3.21
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200418
IMR:0200487
IMR:0200516
KEGG:R02613
KEGG:map00360
event
IEV:0003047
Phenyl-ethylamine + O2 + H2O => Phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
Phenyl-ethylamine + O2 + H2O => Phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.21 )
EC:6.2.1.2
IMR:0001351
IMR:0200083
IMR:0200195
IMR:0200280
IMR:0200308
IMR:0200354
KEGG:R01176
KEGG:map00650
event
IEV:0003048
CoA + ATP + Butanoic acid => Butanoyl-CoA + AMP + Pyrophosphate( EC:6.2.1.2 )
EC:2.3.2.2
IMR:0001695
IMR:0200432
IMR:0200458
KEGG:C03363
KEGG:R03867
KEGG:map00590
event
IEV:0003049
Lucotriene C4 + H2O => Leucotriene D4 + L-Glutamic acid( EC:2.3.2.2 )
Leukotriene C4 + Amino acid => Leukotriene D4 + 5-L-Glutamyl amino acid( EC:2.3.2.2 )
EC:2.7.3.2
IMR:0001351
IMR:0001360
IMR:0200144
IMR:0200204
KEGG:R01881
KEGG:map00330
event
IEV:0003050
ATP + Creatine = ADP + N-Phospho-creatine( EC:2.7.3.2 )
EC:1.2.1.47
IMR:0200030
IMR:0200070
IMR:0200168
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R03283
KEGG:map00310
event
IEV:0003051
NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid( EC:1.2.1.47 )
NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid + H+( EC:1.2.1.47 )
EC:1.2.1.5
IMR:0200030
IMR:0200040
IMR:0200216
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R02695
KEGG:map00350
event
IEV:0003052
NAD+ + 4-Hydroxy-phenyl-acetaldehyde + H2O = NADH + 4-Hydroxy-phenyl-acetic acid( EC:1.2.1.5 )
NAD+ + 4-Hydroxy-phenyl-acetaldehyde + H2O = NADH + 4-Hydroxy-phenyl-acetic acid + H+( EC:1.2.1.5 )
EC:1.17.4.1
IMR:0200078
IMR:0200108
IMR:0200133
IMR:0200357
IMR:0200468
KEGG:R02024
KEGG:map00240
event
IEV:0003053
CDP + Reduced thioredoxin => dCDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
IEV:0002738
EC:2.1.2.10
IMR:0200075
IMR:0200330
IMR:0200367
IMR:0200377
IMR:0200517
KEGG:R04125
KEGG:map00260
KEGG:map00670
S-aminomethyldihydrolipoyllysine + tetrahydrofolate = dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3( EC:2.1.2.10 )
event
IEV:0003054
Dihydro-lipoylprotein + 5,10-Methylene-tetrahydro-folic acid + NH3 => S-Aminomethyl-dihydro-lipoylprotein + L-Tetrahydro-folic acid( EC:2.1.2.10 )
Dihydro-lipoylprotein + 5,10-Methylene-tetrahydro-folic acid + NH3 => S-Aminomethyl-dihydro-lipoylprotein + Tetrahydrofolate( EC:2.1.2.10 )
EC:3.6.1.5
IMR:0200102
IMR:0200357
IMR:0200468
IMR:0200494
KEGG:R00514
KEGG:map00240
event
IEV:0003055
CDP + H2O => CMP + Orthophosphate( EC:3.6.1.5 )
EC:1.5.1.15
IMR:0200159
IMR:0200248
IMR:0200517
IMR:0200521
KEGG:R01218
KEGG:map00670
event
IEV:0003056
NAD+ + 5,10-Methylene-tetrahydro-folic acid = NADH + 5,10-Methenyl-tetrahydro-folic acid( EC:1.5.1.15 )
EC:1.2.4.2
IMR:0002042
IMR:0200378
KEGG:C15972
KEGG:C16254
KEGG:R03316
KEGG:map00020
event
IEV:0003057
3-Carboxy-1-hydroxypropyl-ThPP + Lipoamide = TPP + S-Succinyl-dihydro-lipoamide( EC:1.2.4.2 )
3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine = TPP + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine( EC:1.2.4.2 )
EC:4.4.1.20
IMR:0200318
IMR:0200458
IMR:0200461
KEGG:R03059
KEGG:map00590
event
IEV:0003058
Leukotriene A4 + Glutathione => Leukotriene C4( EC:4.4.1.20 )
EC:2.4.2.3
IMR:0200021
IMR:0200102
IMR:0200234
KEGG:C00620
KEGG:R01876
KEGG:map00240
event
IEV:0003059
Uridine + Orthophosphate = Uracil + D-Ribose 1-phosphate( EC:2.4.2.3 )
EC:1.1.1.21
IMR:0200030
IMR:0200067
IMR:0200462
IMR:0200463
KEGG:C00267
KEGG:R01787
KEGG:map00051
event
IEV:0003060
NADP+ + D-Sorbitol = NADPH + alpha-D-Glucose( EC:1.1.1.21 )
NADP+ + D-Sorbitol = NADPH + alpha-D-Glucose + H+( EC:1.1.1.21 )
EC:4.1.1.28
IMR:0200128
IMR:0200307
IMR:0200324
KEGG:R00685
KEGG:map00380
KEGG:map00901
event
IEV:0003061
L-Tryptophan => Tryptamine + CO2( EC:4.1.1.28 )
EC:2.4.2.1
IMR:0200102
IMR:0200319
IMR:0200445
KEGG:C00620
KEGG:R02147
KEGG:map00230
event
IEV:0003062
Guanosine + Orthophosphate = Guanine + D-Ribose 1-phosphate( EC:2.4.2.1 )
EC:1.8.1.7
IMR:0200030
IMR:0200067
IMR:0200318
IMR:0200364
IMR:0200463
KEGG:R00115
KEGG:map00480
event
IEV:0003063
NADP+ + 2 Glutathione = NADPH + Glutathione disulfide( EC:1.8.1.7 )
NADP+ + 2 Glutathione = NADPH + Glutathione disulfide + H+( EC:1.8.1.7 )
EC:1.14.18.1
IMR:0100113
IMR:0100124
IMR:0200030
IMR:0200217
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R02383
KEGG:map00950
event
IEV:0003064
Tyramine + O2 => Dopamine + H2O( EC:1.14.18.1 )
Tyramine + O2 + NADH + H+ => Dopamine + NAD+ + H2O( EC:1.14.18.1 )
EC:2.7.4.2
IMR:0001351
IMR:0001360
IMR:0200139
IMR:0200431
KEGG:R03245
KEGG:map00900
event
IEV:0003065
ATP + (R)-Mevalonic acid 5-phosphate => ADP + (R)-Mevalonic acid 5-diphosphate( EC:2.7.4.2 )
ATP + (R)-Mevalonic acid 5-phosphate => ADP + (R)-5-Diphosphomevalonate( EC:2.7.4.2 )
EC:1.1.1.44
IMR:0200030
IMR:0200059
IMR:0200061
IMR:0200067
IMR:0200324
IMR:0200463
KEGG:R01528
KEGG:map00030
KEGG:map00480
event
IEV:0003066
NADP+ + 6-Phospho-D-gluconic acid => NADPH + D-Ribulose 5-phosphate + CO2( EC:1.1.1.44 )
NADP+ + 6-Phospho-D-gluconic acid => NADPH + D-Ribulose 5-phosphate + CO2 + H+( EC:1.1.1.44 )
EC:1.3.5.1
IMR:0200119
IMR:0200186
IMR:0200466
IMR:0200483
KEGG:R02164
KEGG:map00020
event
IEV:0003067
Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol( EC:1.3.5.1 )
EC:4.2.1.47
IMR:0200357
IMR:0200451
IMR:0200472
KEGG:R00888
KEGG:map00051
KEGG:map00520
event
IEV:0003068
GDP-D-mannose => GDP-4-dehydro-6-deoxy-D-mannose + H2O( EC:4.2.1.47 )
EC:1.13.11.31
IMR:0200027
IMR:0200212
IMR:0200217
KEGG:R01596
KEGG:map00590
event
IEV:0003069
Arachidonic acid + O2 => 12-HPETE( EC:1.13.11.31 )
Arachidonic acid + O2 => 12(S)-HPETE( EC:1.13.11.31 )
EC:3.1.4.17
IMR:0100025
IMR:0200292
IMR:0200357
KEGG:R01234
KEGG:map00230
event
IEV:0003070
3',5'-Cyclic GMP + H2O => GMP( EC:3.1.4.17 )
EC:1.4.3.21
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200360
IMR:0200471
IMR:0200487
KEGG:R02529
KEGG:map00260
event
IEV:0003071
Amino-acetone + O2 + H2O => Methyl-glyoxal + H2O2 + NH3( EC:1.4.3.6 )
Amino-acetone + O2 + H2O => Methyl-glyoxal + H2O2 + NH3( EC:1.4.3.21 )
EC:2.5.1.61
IMR:0200002
IMR:0200075
IMR:0200357
IMR:0200436
KEGG:R00084
KEGG:map00860
event
IEV:0003072
multi-step reaction
4 Porphobilinogen + H2O => Hydroxy-methylbilane + 4 NH3( EC:2.5.1.61 )
EC:1.2.1.5
IMR:0200030
IMR:0200248
IMR:0200269
IMR:0200357
IMR:0200383
IMR:0200521
KEGG:R04888
KEGG:map00350
event
IEV:0003073
NAD+ + 3-Methoxy-4-hydroxy-phenyl-acetaldehyde + H2O = NADH + Homovanillic acid( EC:1.2.1.5 )
NAD+ + 3-Methoxy-4-hydroxy-phenyl-acetaldehyde + H2O = NADH + Homovanillic acid + H+( EC:1.2.1.5 )
EC:1.2.1.12
IMR:0200030
IMR:0200058
IMR:0200102
IMR:0200248
IMR:0200362
IMR:0200521
KEGG:R01061
KEGG:map00010
event
IEV:0003074
NADH + 1,3-Bisphospho-D-glyceric acid = NAD+ + D-Glyceraldehyde 3-phosphate + Orthophosphate( EC:1.2.1.12 )
NADH + 1,3-Bisphospho-D-glyceric acid + H+ = NAD+ + D-Glyceraldehyde 3-phosphate + Orthophosphate( EC:1.2.1.12 )
EC:2.4.2.14
IMR:0100119
IMR:0200179
IMR:0200280
IMR:0200357
IMR:0200420
IMR:0200448
KEGG:R01072
KEGG:map00230
KEGG:map00250
event
IEV:0003075
L-Glutamine + D-5-Phospho-ribosyl 1-diphosphate + H2O => L-Glutamic acid + 5-Phospho-ribosyl-1-amine + Pyrophosphate( EC:2.4.2.14 )
L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O => L-Glutamic acid + 5-Phospho-ribosyl-1-amine + Pyrophosphate( EC:2.4.2.14 )
EC:1.4.3.4
IMR:0100115
IMR:0200075
IMR:0200217
IMR:0200289
IMR:0200357
IMR:0200487
KEGG:R02532
KEGG:map00350
event
IEV:0003076
L-Noradrenaline + H2O + O2 => 3,4-Dihydroxy-mandelaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:2.3.1.4
IMR:0200228
IMR:0200259
IMR:0200354
IMR:0200414
KEGG:R02058
KEGG:map00520
event
IEV:0003077
Acetyl-CoA + D-Glucosamine 6-phosphate => CoA + N-Acetyl-D-glucosamine 6-phosphate( EC:2.3.1.4 )
EC:3.5.1.6
IMR:0200075
IMR:0200132
IMR:0200324
IMR:0200357
KEGG:C05145
KEGG:R04666
KEGG:map00240
event
IEV:0003078
3-Ureido-2-methyl-propanoic acid + H2O => (S)-3-Amino-2-methyl-propanoic acid + CO2 + NH3( EC:3.5.1.6 )
3-Ureidoisobutyrate + H2O => 3-Aminoisobutyric acid + CO2 + NH3( EC:3.5.1.6 )
EC:2.3.1.26
IMR:0200050
IMR:0200065
IMR:0200354
IMR:0200486
KEGG:R01461
KEGG:map00100
event
IEV:0003079
Acyl-CoA + Cholesterol = CoA + Cholesterol ester( EC:2.3.1.26 )
EC:3.5.2.3
IMR:0200077
IMR:0200357
IMR:0200393
KEGG:R01993
KEGG:map00240
event
IEV:0003080
(S)-Dihydro-orotic acid + H2O = N-Carbamoyl-L-aspartic acid( EC:3.5.2.3 )
EC:3.5.4.16
IMR:0001354
IMR:0200110
IMR:0200357
IMR:0200406
KEGG:R00424
event
IEV:0003081
four-step reaction
GTP + H2O => 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydro-pteridine triphosphate + Formic acid( EC:3.5.4.16 )
EC:4.1.1.28
IMR:0100113
IMR:0200290
IMR:0200324
KEGG:R02080
KEGG:map00350
KEGG:map00950
KEGG:map00965
event
IEV:0003082
L-Dopa => Dopamine + CO2( EC:4.1.1.28 )
EC:2.3.1.87
IMR:0100123
IMR:0200180
IMR:0200354
IMR:0200414
KEGG:R02911
KEGG:map00380
event
IEV:0003083
Acetyl-CoA + Serotonin => CoA + N-Acetyl-serotonin( EC:2.3.1.87 )
EC:3.6.1.9
IMR:0200083
IMR:0200166
IMR:0200248
IMR:0200357
KEGG:R00103
KEGG:map00760
event
IEV:0003084
NAD+ + H2O => Nicotinamide D-ribonucleotide + AMP( EC:3.6.1.9 )
EC:2.6.1.5
IMR:0100119
IMR:0200240
IMR:0200341
IMR:0200480
KEGG:R00734
KEGG:map00130
KEGG:map00350
KEGG:map00400
KEGG:map00401
KEGG:map00950
event
IEV:0003085
2-Oxo-glutaric acid + L-Tyrosine = L-Glutamic acid + 4-Hydroxy-phenyl-pyruvic acid( EC:2.6.1.5 )
EC:2.7.7.9
IMR:0200190
IMR:0200199
IMR:0200280
IMR:0200283
KEGG:R00289
KEGG:map00040
KEGG:map00052
KEGG:map00500
KEGG:map00520
event
IEV:0003086
UTP + D-Glucose 1-phosphate = Pyrophosphate + UDP-D-glucose( EC:2.7.7.9 )
EC:2.3.1.37
IMR:0100118
IMR:0200037
IMR:0200264
IMR:0200324
IMR:0200354
KEGG:R00830
KEGG:map00260
event
IEV:0003087
Glycine + Succinyl-CoA => CO2 + 5-Amino-4-oxo-pentanoic acid + CoA( EC:2.3.1.37 )
EC:2.3.1.16
IMR:0200288
IMR:0200354
IMR:0200414
IMR:0200484
KEGG:R00927
KEGG:map00280
event
IEV:0003088
CoA + 2-Methyl-3-acetoacetyl-CoA => Acetyl-CoA + Propanoyl-CoA( EC:2.3.1.16 )
EC:3.1.2.6
IMR:0002043
IMR:0200313
IMR:0200318
IMR:0200357
KEGG:R01736
KEGG:map00620
event
IEV:0003089
(R)-S-Lactoyl-glutathione + H2O => Glutathione + (R)-Lactic acid( EC:3.1.2.6 )
EC:4.1.1.15
IMR:0200324
IMR:0200438
IMR:0200459
KEGG:R00489
KEGG:map00410
KEGG:map00770
event
IEV:0003090
L-Aspartic acid => beta-Alanine + CO2( EC:4.1.1.15 )
EC:1.14.99.1
IMR:0200224
IMR:0200253
IMR:0200300
IMR:0200357
IMR:0200497
KEGG:R00073
KEGG:map00590
event
IEV:0003091
Prostaglandin G2 + Reduced acceptor => Prostaglandin H2 + H2O + Acceptor( EC:1.14.99.1 )
EC:3.1.3.5
IMR:0200102
IMR:0200104
IMR:0200262
IMR:0200357
KEGG:R03346
KEGG:map00760
event
IEV:0003092
Nicotinate D-ribonucleotide + H2O => Nicotinate D-ribonucleoside + Orthophosphate( EC:3.1.3.5 )
EC:6.3.2.3
IMR:0001351
IMR:0001360
IMR:0100118
IMR:0200102
IMR:0200318
IMR:0200423
KEGG:R00497
KEGG:map00480
event
IEV:0003093
ATP + 5-L-Glutamyl-cysteine + Glycine => ADP + Glutathione + Orthophosphate( EC:6.3.2.3 )
ATP + gamma-L-Glutamyl-L-cysteine + Glycine => ADP + Glutathione + Orthophosphate( EC:6.3.2.3 )
EC:1.13.11.20
IMR:0200217
IMR:0200402
IMR:0200467
KEGG:R00893
KEGG:map00270
KEGG:map00430
event
IEV:0003094
L-Cysteine + O2 => L-Cysteine-sulfinic acid( EC:1.13.11.20 )
EC:1.13.11.6
IMR:0200192
IMR:0200217
IMR:0200400
KEGG:R02665
KEGG:map00380
event
IEV:0003095
3-Hydroxy-anthranilic acid + O2 => 2-Amino-3-carboxy-muconate semialdehyde( EC:1.13.11.6 )
EC:2.5.1.22
IMR:0200092
IMR:0200153
IMR:0200175
IMR:0200285
KEGG:R02869
KEGG:map00270
KEGG:map00330
KEGG:map00410
KEGG:map00480
event
IEV:0003096
S-Adenosyl-L-methioninamine + Spermidine => 5'-Methylthio-adenosine + Spermine( EC:2.5.1.22 )
S-Adenosylmethioninamine + Spermidine => 5'-Methylthio-adenosine + Spermine( EC:2.5.1.22 )
EC:6.2.1.1
IMR:0001351
IMR:0200083
IMR:0200208
IMR:0200280
IMR:0200354
IMR:0200414
KEGG:R00235
KEGG:map00010
KEGG:map00720
event
IEV:0003097
two-step reaction
CoA + ATP + Acetic acid => Acetyl-CoA + AMP + Pyrophosphate( EC:6.2.1.1 )
EC:1.1.1.189
IMR:0200030
IMR:0200051
IMR:0200067
IMR:0200146
IMR:0200463
KEGG:R02581
KEGG:map00590
event
IEV:0003098
NADPH + Prostaglandin E2 => NADP+ + Prostaglandin F2alpha( EC:1.1.1.189 )
NADPH + Prostaglandin E2 + H+ => NADP+ + Prostaglandin F2alpha( EC:1.1.1.189 )
EC:3.1.3.66
IMR:0200102
IMR:0200334
IMR:0200349
IMR:0200357
KEGG:R04372
KEGG:map00562
KEGG:map04070
event
IEV:0003099
1D-myo-Inositol 3,4-bisphosphate + H2O => 1D-myo-Inositol 3-phosphate + Orthophosphate( EC:3.1.3.66 )
EC:5.4.99.2
IMR:0200037
IMR:0200515
KEGG:R00833
KEGG:map00280
KEGG:map00640
event
IEV:0003100
(R)-Methyl-malonyl-CoA = Succinyl-CoA( EC:5.4.99.2 )
EC:4.1.1.37
IMR:0200131
IMR:0200324
IMR:0200522
KEGG:R04972
KEGG:map00860
event
IEV:0003101
Uroporphyrinogen I => Coproporphyrinogen I + 4 CO2( EC:4.1.1.37 )
EC:4.1.1.17
IMR:0200028
IMR:0200324
IMR:0200342
KEGG:R00670
KEGG:map00330
KEGG:map00480
event
IEV:0003102
L-Ornithine => Putrescine + CO2( EC:4.1.1.17 )
EC:2.1.1.49
IMR:0200054
IMR:0200128
IMR:0200151
IMR:0200310
KEGG:R02174
KEGG:map00380
event
IEV:0003103
S-Adenosyl-L-methionine + Tryptamine => S-Adenosyl-L-homocysteine + N-Methyl-tryptamine( EC:2.1.1.49 )
EC:3.5.1.15
IMR:0200208
IMR:0200357
IMR:0200459
IMR:0200478
KEGG:R00488
KEGG:map00250
event
IEV:0003104
N-Acetyl-L-aspartic acid + H2O => L-Aspartic acid + Acetic acid( EC:3.5.1.15 )
EC:1.4.3.22
IMR:0100125
IMR:0200075
IMR:0200217
IMR:0200352
IMR:0200357
IMR:0200487
KEGG:R02150
KEGG:map00340
event
IEV:0003105
Histamine + O2 + H2O => Imidazole-4-acetaldehyde + NH3 + H2O2( EC:1.4.3.6 )
Histamine + O2 + H2O => Imidazole-4-acetaldehyde + NH3 + H2O2( EC:1.4.3.22 )
EC:5.4.2.3
IMR:0200259
KEGG:C04501
KEGG:R08193
KEGG:map00520
event
IEV:0003106
N-Acetyl-D-glucosamine 1-phosphate = N-Acetyl-D-glucosamine 6-phosphate( EC:5.4.2.3 )
N-Acetyl-alpha-D-glucosamine 1-phosphate = N-Acetyl-D-glucosamine 6-phosphate( EC:5.4.2.3 )
EC:1.1.1.-
IMR:0200030
IMR:0200067
IMR:0200136
IMR:0200463
IMR:0200471
KEGG:R02528
KEGG:map00260
event
IEV:0003107
NAD+ + Hydroxy-acetone = NADH + Methyl-glyoxal( EC:1.1.1.- )
NADP+ + Hydroxy-acetone = NADPH + Methyl-glyoxal + H+( EC:1.1.1.- )
EC:3.1.3.56
IMR:0100028
IMR:0100698
IMR:0200102
IMR:0200357
KEGG:R03394
KEGG:map00562
KEGG:map04070
event
IEV:0003108
1D-myo-Inositol 1,4,5-trisphosphate + H2O => 1D-myo-Inositol 1,4-bisphosphate + Orthophosphate( EC:3.1.3.56 )
EC:4.1.1.15
IMR:0100120
IMR:0200324
IMR:0200417
KEGG:R01682
KEGG:map00430
event
IEV:0003109
L-Cysteic acid => Taurine + CO2( EC:4.1.1.15 )
EC:2.7.1.11
IMR:0001351
IMR:0001360
KEGG:C05345
KEGG:C05378
KEGG:R04779
KEGG:map00010
KEGG:map00030
KEGG:map00051
event
IEV:0003110
ATP + D-Fructose 6-phosphate => ADP + D-Fructose 1,6-bisphosphate( EC:2.7.1.11 )
ATP + beta-D-Fructose 6-phosphate => ADP + beta-D-Fructose 1,6-bisphosphate( EC:2.7.1.11 )
EC:1.3.3.4
IMR:0200089
IMR:0200217
IMR:0200357
IMR:0200523
KEGG:R03222
KEGG:map00860
event
IEV:0003111
Protoporphyrinogen IX + 1.5 O2 => Protoporphyrin IX + 3 H2O( EC:1.3.3.4 ):multi-step reaction
2 Protoporphyrinogen IX + 3 O2 => 2 Protoporphyrin IX + 6 H2O( EC:1.3.3.4 )
EC:6.1.1.17
IMR:0001351
IMR:0100119
IMR:0200083
IMR:0200125
IMR:0200231
IMR:0200280
KEGG:R05578
KEGG:map00860
KEGG:map00970
event
IEV:0003112
ATP + L-Glutamic acid + tRNA(Glu) => AMP + L-Glutamyl-tRNA(Glu) + Pyrophosphate( EC:6.1.1.17 )
EC:2.7.1.40
IMR:0001354
IMR:0001357
IMR:0200223
IMR:0200331
KEGG:R00430
KEGG:map00230
event
IEV:0003113
GDP + Phosphoenol-pyruvic acid => GTP + Pyruvic acid( EC:2.7.1.40 )
EC:1.2.1.3
IMR:0200030
IMR:0200248
IMR:0200357
IMR:0200389
IMR:0200416
IMR:0200521
KEGG:R02678
KEGG:map00380
event
IEV:0003114
NAD+ + Indole-3-acetaldehyde + H2O => NADH + Indole-3-acetic acid( EC:1.2.1.3 )
NAD+ + Indole-3-acetaldehyde + H2O => NADH + Indole-3-acetic acid + H+( EC:1.2.1.3 )
EC:3.6.1.17
IMR:0001354
IMR:0200043
IMR:0200292
IMR:0200357
KEGG:R01232
KEGG:map00230
event
IEV:0003115
P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMP( EC:3.6.1.17 )
EC:4.1.1.28
IMR:0200274
IMR:0200324
IMR:0200516
KEGG:R00699
KEGG:map00360
event
IEV:0003116
L-Phenylalanine => Phenyl-ethylamine + CO2( EC:4.1.1.28 )
EC:2.7.4.14
IMR:0001351
IMR:0001360
IMR:0200468
IMR:0200494
KEGG:R00512
KEGG:map00240
event
IEV:0003117
ATP + CMP = ADP + CDP( EC:2.7.4.14 )
EC:2.7.1.6
IMR:0001351
IMR:0001360
IMR:0200123
IMR:0200304
KEGG:R01092
KEGG:map00052
KEGG:map00520
event
IEV:0003118
ATP + D-Galactose => ADP + D-Galactose 1-phosphate( EC:2.7.1.6 )
ATP + D-Galactose => ADP + alpha-D-Galactose 1-phosphate( EC:2.7.1.6 )
EC:6.2.1.16
IMR:0001351
IMR:0200064
IMR:0200083
IMR:0200280
IMR:0200354
IMR:0200410
KEGG:R01357
KEGG:map00650
event
IEV:0003119
CoA + ATP + Acetoacetic acid => Acetoacetyl-CoA + AMP + Pyrophosphate( EC:6.2.1.16 )
EC:3.6.1.5
IMR:0200102
IMR:0200206
IMR:0200357
IMR:0200409
KEGG:R00155
KEGG:map00240
event
IEV:0003120
UDP + H2O => UMP + Orthophosphate( EC:3.6.1.5 )
EC:1.2.1.5
IMR:0200030
IMR:0200068
IMR:0200248
IMR:0200289
IMR:0200357
IMR:0200521
KEGG:R04882
KEGG:map00350
event
IEV:0003121
NAD+ + 3,4-Dihydroxy-mandelaldehyde + H2O = NADH + 3,4-Dihydroxy-mandelic acid( EC:1.2.1.5 )
NAD+ + 3,4-Dihydroxy-mandelaldehyde + H2O = NADH + 3,4-Dihydroxy-mandelic acid + H+( EC:1.2.1.5 )
EC:3.2.1.23
IMR:0200085
IMR:0200123
IMR:0200357
KEGG:R01105
KEGG:map00052
event
IEV:0003122
notice: Galactan + H2O <=> D-Galactose + Galactan( EC:3.2.1.23 )
Galactan + H2O => 2 D-Galactose( EC:3.2.1.23 )
EC:5.5.1.4
IMR:0200349
IMR:0200430
KEGG:R07324
KEGG:map00521
KEGG:map00562
event
IEV:0003123
D-Glucose 6-phosphate => D-myo-Inositol 1-phosphate( EC:5.5.1.4 )
D-Glucose 6-phosphate => D-myo-Inositol 3-phosphate( EC:5.5.1.4 )
EC:1.4.3.4
IMR:0200075
IMR:0200217
IMR:0200333
IMR:0200357
IMR:0200421
IMR:0200487
KEGG:R04025
KEGG:map00330
event
IEV:0003124
N-Acetyl-putrescine + H2O + O2 => N4-Acetyl-amino-butyraldehyde + NH3 + H2O2( EC:1.4.3.4 )
N-Acetyl-putrescine + H2O + O2 => N4-Acetylaminobutanal + NH3 + H2O2( EC:1.4.3.4 )
EC:1.1.1.27
IMR:0200030
IMR:0200127
IMR:0200219
IMR:0200248
IMR:0200521
KEGG:R01000
KEGG:map00640
event
IEV:0003125
NAD+ + 2-Hydroxy-butanoic acid = NADH + 2-Oxo-butanoic acid( EC:1.1.1.27 )
NAD+ + 2-Hydroxy-butanoic acid = NADH + 2-Oxo-butanoic acid + H+( EC:1.1.1.27 )
EC:3.5.1.9
IMR:0200110
IMR:0200357
IMR:0200411
IMR:0200491
KEGG:R04911
KEGG:map00380
event
IEV:0003126
5-Hydroxy-N-formyl-kynurenine + H2O => 5-Hydroxy-kynurenine + Formic acid( EC:3.5.1.9 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200129
IMR:0200237
KEGG:R01137
KEGG:map00230
event
IEV:0003127
ATP + dADP = ADP + dATP( EC:2.7.4.6 )
EC:4.4.1.1
IMR:0200075
IMR:0200331
IMR:0200357
IMR:0200440
IMR:0200475
KEGG:R02408
KEGG:map00270
event
IEV:0003128
L-Cystine + H2O => Thiocysteine + Pyruvic acid + NH3( EC:4.4.1.1 )
EC:2.1.1.17
IMR:0200054
IMR:0200151
IMR:0200317
IMR:0200361
KEGG:R02056
KEGG:map00564
event
IEV:0003129
S-Adenosyl-L-methionine + Phosphatidyl-ethanolamine => S-Adenosyl-L-homocysteine + Phosphatidyl-N-methyl-ethanolamine( EC:2.1.1.17 )
EC:4.1.1.23
IMR:0200087
IMR:0200324
IMR:0200409
KEGG:R00965
KEGG:map00240
event
IEV:0003130
5'-Orotidylic acid => UMP + CO2( EC:4.1.1.23 )
Orotidine 5'-phosphate => UMP + CO2( EC:4.1.1.23 )
EC:2.4.2.1
IMR:0200102
IMR:0200104
IMR:0200415
KEGG:C00620
KEGG:R02295
KEGG:map00760
event
IEV:0003131
Nicotinate D-ribonucleoside + Orthophosphate = Nicotinic acid + D-Ribose 1-phosphate( EC:2.4.2.1 )
EC:2.7.7.43
IMR:0200024
IMR:0200172
IMR:0200202
IMR:0200280
KEGG:R04215
KEGG:map00520
event
IEV:0003132
CTP + N-Glycolyl-neuraminic acid => Pyrophosphate + CMP-N-glycolyl-neuraminic acid( EC:2.7.7.43 )
EC:1.4.3.22
IMR:0200075
IMR:0200128
IMR:0200217
IMR:0200357
IMR:0200416
IMR:0200487
KEGG:R02173
KEGG:map00380
event
IEV:0003133
Tryptamine + O2 + H2O => Indole-3-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
Tryptamine + O2 + H2O => Indole-3-acetaldehyde + H2O2 + NH3( EC:1.4.3.22 )
EC:3.1.3.5
IMR:0200102
IMR:0200165
IMR:0200357
IMR:0200426
KEGG:R02719
KEGG:map00230
event
IEV:0003134
XMP + H2O => Xanthosine + Orthophosphate( EC:3.1.3.5 )
EC:2.7.4.6
IMR:0001351
IMR:0001354
IMR:0001357
IMR:0001360
KEGG:R00330
KEGG:map00230
event
IEV:0003135
ATP + GDP = ADP + GTP( EC:2.7.4.6 )
EC:2.5.1.10
IMR:0200097
IMR:0200280
IMR:0200287
IMR:0200399
KEGG:R02003
KEGG:map00900
event
IEV:0003136
Isopentenyl diphosphate + Geranyl diphosphate => Farnesyl diphosphate + Pyrophosphate( EC:2.5.1.10 )
EC:4.2.1.17
IMR:0200164
IMR:0200357
IMR:0200434
KEGG:R04224
KEGG:map00280
event
IEV:0003137
(S)-3-Hydroxy-2-methyl-propanoyl-CoA = 2-Methylprop-2-enoyl-CoA + H2O( EC:4.2.1.17 )
(S)-3-Hydroxyisobutyryl-CoA = 2-Methylprop-2-enoyl-CoA + H2O( EC:4.2.1.17 )
EC:1.4.3.21
IMR:0100124
IMR:0200040
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:R02382
KEGG:map00350
event
IEV:0003138
Tyramine + O2 + H2O => 4-Hydroxy-phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
Tyramine + O2 + H2O => 4-Hydroxy-phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.21 )
EC:6.3.5.5
IMR:0001351
IMR:0001360
IMR:0100119
IMR:0200102
IMR:0200109
IMR:0200357
IMR:0200448
KEGG:C00288
KEGG:R00575
KEGG:map00240
KEGG:map00250
event
IEV:0003139
ATP + L-Glutamine + CO2 + 2 H2O => ADP + L-Glutamic acid + Carbamic acid + Orthophosphate( EC:6.3.5.5 ): two-step reaction.
2 ATP + L-Glutamine + HCO3- + H2O = 2 ADP + L-Glutamic acid + Carbamoyl phosphate + Orthophosphate( EC:6.3.5.5 )
EC:1.14.11.1
IMR:0200035
IMR:0200119
IMR:0200168
IMR:0200217
IMR:0200324
IMR:0200480
KEGG:R02397
KEGG:map00310
event
IEV:0003140
4-Trimethyl-ammonio-butanoic acid + 2-Oxo-glutaric acid + O2 => Carnitine + Succinic acid + CO2( EC:1.14.11.1 )
EC:2.1.1.4
IMR:0100069
IMR:0200054
IMR:0200151
IMR:0200180
KEGG:R03130
KEGG:map00380
event
IEV:0003141
S-Adenosyl-L-methionine + N-Acetyl-serotonin => S-Adenosyl-L-homocysteine + Melatonin( EC:2.1.1.4 )
EC:2.7.1.105
IMR:0001351
IMR:0001360
IMR:0200263
KEGG:C05345
KEGG:R02732
KEGG:map00051
event
IEV:0003142
ATP + D-Fructose 6-phosphate => ADP + D-Fructose 2,6-bisphosphate( EC:2.7.1.105 )
ATP + beta-D-Fructose 6-phosphate => ADP + D-Fructose 2,6-bisphosphate( EC:2.7.1.105 )
EC:4.1.1.22
IMR:0100125
IMR:0200137
IMR:0200324
KEGG:R01167
KEGG:map00340
event
IEV:0003143
L-Histidine => Histamine + CO2( EC:4.1.1.22 )
EC:2.7.1.40
IMR:0200129
IMR:0200223
IMR:0200237
IMR:0200331
KEGG:R01138
KEGG:map00230
event
IEV:0003144
dADP + Phosphoenol-pyruvic acid => dATP + Pyruvic acid( EC:2.7.1.40 )
EC:1.3.99.2
IMR:0200030
IMR:0200121
IMR:0200195
IMR:0200248
IMR:0200521
KEGG:R01171
KEGG:map00650
event
IEV:0003145
Butanoyl-CoA + Acceptor = Crotonoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
Butanoyl-CoA + NAD+ = Crotonoyl-CoA + NADH + H+( EC:1.3.99.2 )
EC:1.1.1.41
IMR:0200023
IMR:0200030
IMR:0200248
IMR:0200324
IMR:0200480
IMR:0200521
KEGG:R00709
KEGG:map00020
event
IEV:0003146
NAD+ + Isocitric acid = NADH + 2-Oxo-glutaric acid + CO2( EC:1.1.1.41 )
NAD+ + Isocitric acid = NADH + 2-Oxo-glutaric acid + CO2 + H+( EC:1.1.1.41 )
EC:1.4.3.4
IMR:0100113
IMR:0200075
IMR:0200217
IMR:0200346
IMR:0200357
IMR:0200487
KEGG:R04300
KEGG:map00350
KEGG:map00950
event
IEV:0003147
Dopamine + H2O + O2 => 3,4-Dihydroxy-phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:6.3.2.-
IMR:0200010
IMR:0200052
KEGG:R04906
KEGG:map00380
event
IEV:0003148
ATP + 5-Hydroxy-indole-acetic acid + Glycine => ADP + 5-Hydroxy-indole-acetylglycine + Orthophosphate( EC:6.3.2.- )
5-Hydroxy-indole-acetic acid => 5-Hydroxy-indole-acetylglycine( EC:6.3.2.- )
EC:1.14.21.6
IMR:0200030
IMR:0200067
IMR:0200217
IMR:0200296
IMR:0200357
IMR:0200463
IMR:0200510
KEGG:R07215
KEGG:map00100
event
IEV:0003149
NADPH + 5-cholest-7-en-3-ol + O2 => NADP+ + 7-Dehydro-cholesterol + H2O2( EC:1.14.21.6 )
NADPH + 5alpha-Cholest-7-en-3beta-ol + O2 + H+ => NADP+ + 7-Dehydro-cholesterol + 2 H2O( EC:1.14.21.6 )
EC:3.1.3.5
IMR:0200021
IMR:0200102
IMR:0200357
IMR:0200409
KEGG:R00963
KEGG:map00240
event
IEV:0003150
UMP + H2O => Uridine + Orthophosphate( EC:3.1.3.5 )
EC:6.1.1.3
IMR:0001351
IMR:0200083
IMR:0200154
IMR:0200280
IMR:0200444
IMR:0200502
KEGG:R03663
KEGG:map00970
event
IEV:0003151
ATP + L-Threonine + tRNA(Thr) => AMP + L-Threonyl-tRNA(Thr) + Pyrophosphate( EC:6.1.1.3 )
EC:4.2.1.17
IMR:0200207
IMR:0200357
IMR:0200465
KEGG:R04204
KEGG:map00280
event
IEV:0003152
(S)-3-Hydroxy-2-methyl-butanoyl-CoA = 2-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA = 2-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
EC:1.2.1.5
IMR:0200026
IMR:0200030
IMR:0200248
IMR:0200346
IMR:0200357
IMR:0200521
KEGG:R03300
KEGG:map00350
event
IEV:0003153
NAD+ + 3,4-Dihydroxy-phenyl-acetaldehyde + H2O = NADH + 3,4-Dihydroxy-phenyl-acetic acid( EC:1.2.1.5 )
NAD+ + 3,4-Dihydroxy-phenyl-acetaldehyde + H2O = NADH + 3,4-Dihydroxy-phenyl-acetic acid + H+( EC:1.2.1.5 )
EC:3.6.1.7
IMR:0200102
IMR:0200208
IMR:0200266
IMR:0200357
KEGG:R00317
KEGG:map00620
event
IEV:0003154
Acetyl phosphate + H2O = Acetic acid + Orthophosphate( EC:3.6.1.7 )
EC:6.3.5.1
IMR:0001351
IMR:0100119
IMR:0200082
IMR:0200083
IMR:0200248
IMR:0200280
IMR:0200357
IMR:0200448
KEGG:R00257
KEGG:map00760
event
IEV:0003155
ATP + Deamido-NAD+ + L-Glutamine + H2O => AMP + NAD+ + L-Glutamic acid + Pyrophosphate( EC:6.3.5.1 )
EC:2.7.1.35
IMR:0001351
IMR:0001360
IMR:0200344
IMR:0200429
KEGG:R01909
KEGG:map00750
event
IEV:0003156
ATP + Pyridoxine => ADP + Pyridoxine 5'-phosphate( EC:2.7.1.35 )
EC:3.1.3.5
IMR:0100126
IMR:0200083
IMR:0200102
IMR:0200357
KEGG:R00183
KEGG:map00230
event
IEV:0003157
AMP + H2O => Adenosine + Orthophosphate( EC:3.1.3.5 )
EC:1.5.1.2
IMR:0200030
IMR:0200183
IMR:0200236
IMR:0200248
IMR:0200521
KEGG:R01248
KEGG:map00330
event
IEV:0003158
NADH + (S)-1-Pyrroline-5-carboxylic acid = NAD+ + L-Proline( EC:1.5.1.2 )
NADH + (S)-1-Pyrroline-5-carboxylic acid + H+ = NAD+ + L-Proline( EC:1.5.1.2 )
EC:1.4.3.4
IMR:0200075
IMR:0200128
IMR:0200217
IMR:0200357
IMR:0200416
IMR:0200487
KEGG:R02173
KEGG:map00380
event
IEV:0003159
Tryptamine + H2O + O2 => Indole-3-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:1.2.4.1
IMR:0200055
IMR:0200378
KEGG:C15972
KEGG:C16255
KEGG:R03270
KEGG:map00010
KEGG:map00020
KEGG:map00620
event
IEV:0003160
2-(Hydroxyethyl)-thiamine diphosphate + Lipoamide => TPP + 6-S-Acetyl-dihydro-lipoamide( EC:1.2.4.1 )
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine => TPP + [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine( EC:1.2.4.1 )
EC:2.1.1.49
IMR:0100123
IMR:0200054
IMR:0200151
IMR:0200386
KEGG:R02910
KEGG:map00380
event
IEV:0003161
S-Adenosyl-L-methionine + Serotonin => S-Adenosyl-L-homocysteine + N-Methyl-serotonin( EC:2.1.1.49 )
EC:2.6.1.42
IMR:0100119
IMR:0200272
IMR:0200480
KEGG:C00671
KEGG:R02199
KEGG:map00280
KEGG:map00290
KEGG:map00966
event
IEV:0003162
2-Oxo-glutaric acid + L-Isoleucine = L-Glutamic acid + (R)-2-Oxo-3-methyl-pentanoic acid( EC:2.6.1.42 )
2-Oxo-glutaric acid + L-Isoleucine = L-Glutamic acid + (S)-3-Methyl-2-oxopentanoic acid( EC:2.6.1.42 )
EC:2.6.1.52
IMR:0100119
IMR:0200329
IMR:0200427
IMR:0200480
KEGG:R04173
KEGG:map00260
event
IEV:0003163
2-Oxo-glutaric acid + L-O-Phospho-serine = L-Glutamic acid + 3-Phospho-hydroxy-pyruvic acid( EC:2.6.1.52 )
EC:2.3.3.8
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200339
IMR:0200354
IMR:0200414
IMR:0200473
KEGG:R00352
KEGG:map00020
KEGG:map00720
event
IEV:0003164
multi-step reaction
ATP + CoA + Citric acid = ADP + Acetyl-CoA + Oxaloacetic acid + Orthophosphate( EC:2.3.3.8 )
EC:2.4.1.22
IMR:0200042
IMR:0200206
IMR:0200227
IMR:0200277
KEGG:R00503
KEGG:map00052
event
IEV:0003165
UDP-D-galactose + D-Glucose => UDP + Lactose( EC:2.4.1.22 )
EC:1.2.1.31
IMR:0200030
IMR:0200248
IMR:0200294
IMR:0200322
IMR:0200357
IMR:0200521
KEGG:R03102
KEGG:map00310
event
IEV:0003166
NAD+ + L-2-Amino-adipate 6-semialdehyde + H2O = NADH + L-2-Amino-adipic acid( EC:1.2.1.31 )
NAD+ + L-2-Amino-adipate 6-semialdehyde + H2O = NADH + L-2-Amino-adipic acid + H+( EC:1.2.1.31 )
EC:6.1.1.15
IMR:0001351
IMR:0200001
IMR:0200083
IMR:0200183
IMR:0200280
IMR:0200359
KEGG:R03661
KEGG:map00970
event
IEV:0003167
ATP + L-Proline + tRNA(Pro) => AMP + L-Prolyl-tRNA(Pro) + Pyrophosphate( EC:6.1.1.15 )
EC:2.7.1.20
IMR:0001351
IMR:0001360
IMR:0100126
IMR:0200083
KEGG:R00185
KEGG:map00230
event
IEV:0003168
ATP + Adenosine => ADP + AMP( EC:2.7.1.20 )
EC:2.5.1.21
IMR:0200030
IMR:0200067
IMR:0200097
IMR:0200280
IMR:0200463
IMR:0200481
KEGG:R06223
event
IEV:0003169
2 Farnesyl diphosphate + NADPH => NADP+ + Squalene + 2 Pyrophosphate( EC:2.5.1.21 ):two-step reaction
2 Farnesyl diphosphate + NADPH + H+ => NADP+ + Squalene + 2 Pyrophosphate( EC:2.5.1.21 )
EC:1.1.1.27
IMR:0200007
IMR:0200030
IMR:0200248
IMR:0200498
IMR:0200521
KEGG:R03104
KEGG:map00270
event
IEV:0003170
NAD+ + 3-Mercapto-lactic acid = NADH + 3-Mercapto-pyruvic acid( EC:1.1.1.27 )
NAD+ + 3-Mercapto-lactic acid = NADH + 3-Mercapto-pyruvic acid + H+( EC:1.1.1.27 )
EC:5.1.3.14
IMR:0200206
IMR:0200247
IMR:0200282
IMR:0200357
KEGG:R00414
KEGG:map00520
event
IEV:0003171
UDP-N-acetyl-D-glucosamine + H2O => UDP + N-acetyl-D-mannosamine( EC:5.1.3.14 )
EC:1.14.13.17
IMR:0200030
IMR:0200067
IMR:0200217
IMR:0200357
IMR:0200404
IMR:0200463
IMR:0200486
KEGG:R01463
KEGG:map00120
event
IEV:0003172
NADPH + Cholesterol + O2 = NADP+ + 7-Hydroxy-cholesterol + H2O( EC:1.14.13.17 )
NADPH + Cholesterol + O2 + H+ = NADP+ + 7alpha-Hydroxycholesterol + H2O( EC:1.14.13.17 )
EC:1.4.3.22
IMR:0200028
IMR:0200075
IMR:0200142
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:R01151
KEGG:map00330
event
IEV:0003173
Putrescine + O2 + H2O => 4-Amino-butyraldehyde + H2O2 + NH3( EC:1.4.3.6 )
Putrescine + O2 + H2O => 4-Amino-butyraldehyde + H2O2 + NH3( EC:1.4.3.22 )
EC:6.3.5.4
IMR:0001351
IMR:0100119
IMR:0200083
IMR:0200113
IMR:0200280
IMR:0200357
IMR:0200448
IMR:0200459
KEGG:R00578
KEGG:map00250
KEGG:map00910
event
IEV:0003175
ATP + L-Glutamine + L-Aspartic acid + H2O => AMP + L-Glutamic acid + L-Asparagine + Pyrophosphate( EC:6.3.5.4 )
EC:1.7.1.7
IMR:0200030
IMR:0200067
IMR:0200075
IMR:0200221
IMR:0200292
IMR:0200463
KEGG:R01134
KEGG:map00230
event
IEV:0003176
NADPH + GMP => NADP+ + IMP + NH3( EC:1.7.1.7 )
NADPH + GMP + H+ => NADP+ + IMP + NH3( EC:1.7.1.7 )
EC:2.3.1.57
IMR:0200028
IMR:0200333
IMR:0200354
IMR:0200414
KEGG:R01154
KEGG:map00330
event
IEV:0003177
Acetyl-CoA + Putrescine => CoA + N-Acetyl-putrescine( EC:2.3.1.57 )
EC:4.3.1.4
IMR:0200030
IMR:0200075
IMR:0200159
IMR:0200443
KEGG:R02302
KEGG:map00670
event
IEV:0003178
5-Formimino-tetrahydro-folic acid = 5,10-Methenyl-tetrahydro-folic acid + NH3( EC:4.3.1.4 )
5-Formimino-tetrahydro-folic acid + H+ = 5,10-Methenyl-tetrahydro-folic acid + NH3( EC:4.3.1.4 )
EC:2.7.4.8
IMR:0001351
IMR:0001357
IMR:0001360
IMR:0200292
KEGG:R00332
KEGG:map00230
event
IEV:0003179
ATP + GMP = ADP + GDP( EC:2.7.4.8 )
EC:3.1.3.25
IMR:0200102
IMR:0200177
IMR:0200349
IMR:0200357
KEGG:R01187
KEGG:map00521
KEGG:map00562
KEGG:map04070
event
IEV:0003180
1D-myo-Inositol 3-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
EC:1.2.4.1
IMR:0200055
IMR:0200324
IMR:0200331
IMR:0200378
KEGG:R00014
KEGG:map00010
KEGG:map00020
KEGG:map00290
KEGG:map00620
KEGG:map00650
event
IEV:0003181
TPP + Pyruvic acid => 2-(Hydroxyethyl)-thiamine diphosphate + CO2( EC:1.2.4.1 ):subsequently IEV:0003160
TPP + Pyruvic acid => 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2( EC:1.2.4.1 )
EC:3.1.1.31
IMR:0200059
IMR:0200357
IMR:0200508
KEGG:R02035
KEGG:map00030
event
IEV:0003182
D-6-Phospho-glucono 1,5-lactone + H2O => 6-Phospho-D-gluconic acid( EC:3.1.1.31 )
D-Glucono-1,5-lactone 6-phosphate + H2O => 6-Phospho-D-gluconic acid( EC:3.1.1.31 )
EC:6.3.5.3
IMR:0001351
IMR:0001360
IMR:0100119
IMR:0200022
IMR:0200102
IMR:0200357
IMR:0200398
IMR:0200448
KEGG:R04463
KEGG:map00230
event
IEV:0003183
ATP + 5'-Phospho-ribosyl-N-formyl-glycinamide + L-Glutamine + H2O => ADP + 5'-Phospho-ribosyl-N-formyl-glycinamidine + L-Glutamic acid + Orthophosphate( EC:6.3.5.3 )
EC:1.13.11.52
IMR:0200112
IMR:0200217
IMR:0200411
KEGG:R02702
KEGG:map00380
event
IEV:0003184
5-Hydroxy-L-Tryptophan + O2 => 5-Hydroxy-N-formyl-kynurenine( EC:1.13.11.42 )
5-Hydroxy-L-Tryptophan + O2 => 5-Hydroxy-N-formyl-kynurenine( EC:1.13.11.52 )
EC:4.2.1.24
IMR:0200264
IMR:0200357
IMR:0200436
KEGG:R00036
KEGG:map00860
event
IEV:0003185
2 5-Amino-4-oxo-pentanoic acid => Porphobilinogen + 2 H2O( EC:4.2.1.24 )
EC:3.5.4.10
IMR:0200221
IMR:0200357
IMR:0200452
KEGG:R01127
KEGG:map00230
event
IEV:0003186
IMP + H2O = 5'-Phospho-ribosyl-4-carboxamido-5-formamido-imidazole( EC:3.5.4.10 )
IMP + H2O = 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide( EC:3.5.4.10 )
EC:3.6.1.19
IMR:0200008
IMR:0200056
IMR:0200280
IMR:0200357
KEGG:R02100
KEGG:map00240
event
IEV:0003187
dUTP + H2O => dUMP + Pyrophosphate( EC:3.6.1.19 )
EC:6.3.2.2
IMR:0001351
IMR:0001360
IMR:0100119
IMR:0200102
IMR:0200423
IMR:0200467
KEGG:R00894
KEGG:map00480
event
IEV:0003188
ATP + L-Glutamic acid + L-Cysteine => ADP + 5-L-Glutamyl-cysteine + Orthophosphate( EC:6.3.2.2 )
ATP + L-Glutamic acid + L-Cysteine => ADP + gamma-L-Glutamyl-L-cysteine + Orthophosphate( EC:6.3.2.2 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
IMR:0200056
IMR:0200098
KEGG:R02331
KEGG:map00240
event
IEV:0003189
ATP + dUDP = ADP + dUTP( EC:2.7.4.6 )
EC:1.14.11.8
IMR:0200119
IMR:0200217
IMR:0200324
IMR:0200326
IMR:0200480
IMR:0200493
KEGG:R03451
KEGG:map00310
event
IEV:0003190
N6,N6,N6-Trimethyl-L-lysine + 2-Oxo-glutaric acid + O2 => 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine + Succinic acid + CO2( EC:1.14.11.8 )
EC:6.3.2.17
IMR:0001351
IMR:0001360
IMR:0100119
IMR:0200102
IMR:0200157
IMR:0200330
KEGG:R00942
KEGG:map00790
event
IEV:0003191
ATP + L-Tetrahydro-folic acid + L-Glutamic acid => ADP + Tetrahydrofolyl-[Glu] + Orthophosphate( EC:6.3.2.17 )
ATP + Tetrahydrofolate + L-Glutamic acid => ADP + Tetrahydrofolyl-[Glu] + Orthophosphate( EC:6.3.2.17 )
EC:3.1.3.56
IMR:0100029
IMR:0200102
IMR:0200124
IMR:0200357
KEGG:R03430
KEGG:map00562
KEGG:map04070
event
IEV:0003192
1D-myo-Inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-Inositol 1,3,4-trisphosphate + Orthophosphate( EC:3.1.3.56 )
EC:3.6.1.5
IMR:0200102
IMR:0200199
IMR:0200206
IMR:0200357
KEGG:R00159
KEGG:map00240
event
IEV:0003193
UTP + H2O => UDP + Orthophosphate( EC:3.6.1.5 )
EC:2.7.1.3
IMR:0001351
IMR:0001360
IMR:0200120
IMR:0200474
KEGG:R00866
KEGG:map00051
event
IEV:0003194
ATP + D-Fructose => ADP + D-Fructose 1-phosphate( EC:2.7.1.3 )
EC:1.4.3.5
IMR:0200217
IMR:0200229
IMR:0200429
IMR:0200487
KEGG:R00278
KEGG:map00750
event
IEV:0003195
Pyridoxine 5'-phosphate + O2 => Pyridoxal 5'-phosphate + H2O2( EC:1.4.3.5 )
EC:1.14.13.9
IMR:0200030
IMR:0200066
IMR:0200067
IMR:0200217
IMR:0200301
IMR:0200357
IMR:0200463
KEGG:R01960
KEGG:map00380
event
IEV:0003196
NADPH + L-Kynurenine + O2 => NADP+ + 3-Hydroxy-L-kynurenine + H2O( EC:1.14.13.9 )
NADPH + L-Kynurenine + O2 + H+ => NADP+ + 3-Hydroxy-L-kynurenine + H2O( EC:1.14.13.9 )
EC:1.14.16.2
IMR:0200045
IMR:0200209
IMR:0200217
IMR:0200240
IMR:0200290
IMR:0200357
KEGG:R01815
KEGG:map00350
event
IEV:0003197
L-Tyrosine + Tetrahydrobiopterin + O2 => L-Dopa + 6,7-Dihydro-biopterin + H2O( EC:1.14.16.2 )
EC:6.3.4.13
IMR:0001351
IMR:0001360
IMR:0100118
IMR:0200102
IMR:0200252
IMR:0200420
KEGG:R04144
KEGG:map00230
event
IEV:0003198
ATP + 5-Phospho-ribosyl-1-amine + Glycine => ADP + 5'-Phospho-ribosyl-glycinamide + Orthophosphate( EC:6.3.4.13 )
EC:1.5.1.12
IMR:0100119
IMR:0200030
IMR:0200236
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R00707
KEGG:map00250
KEGG:map00330
event
IEV:0003199
NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid( EC:1.5.1.12 ):two-step reaction
NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid + H+( EC:1.5.1.12 )
EC:3.1.3.5
IMR:0200102
IMR:0200187
IMR:0200357
IMR:0200384
KEGG:R01569
KEGG:map00240
event
IEV:0003200
dTMP + H2O => Thymidine + Orthophosphate( EC:3.1.3.5 )
EC:3.5.1.15
IMR:0200049
IMR:0200110
IMR:0200357
IMR:0200459
KEGG:R00526
KEGG:map00340
KEGG:map00630
event
IEV:0003201
N-Formyl-L-aspartic acid + H2O => L-Aspartic acid + Formic acid( EC:3.5.1.15 )
EC:2.7.1.137
IMR:0001351
IMR:0001360
IMR:0200387
IMR:0200469
KEGG:R03362
KEGG:map00562
KEGG:map04070
event
IEV:0003202
ATP + 1-Phosphatidyl-1D-myo-inositol => ADP + 1-Phosphatidyl-1D-myo-inositol 3-phosphate( EC:2.7.1.137 )
EC:2.7.1.35
IMR:0001351
IMR:0001360
IMR:0200229
IMR:0200504
KEGG:R00174
KEGG:map00750
event
IEV:0003203
ATP + Pyridoxal => ADP + Pyridoxal 5'-phosphate( EC:2.7.1.35 )
EC:1.2.1.71
IMR:0200030
IMR:0200222
IMR:0200248
IMR:0200357
IMR:0200369
IMR:0200521
KEGG:R05049
KEGG:map00330
event
IEV:0003204
NAD+ + N2-Succinyl-L-glutamate 5-semialdehyde + H2O => NADH + N2-Succinyl-L-glutamic acid( EC:1.5.1.12 )
NAD+ + N-Succinyl-L-glutamate 5-semialdehyde + H2O => NADH + N-Succinyl-L-glutamic acid + H+( EC:1.2.1.71 )
EC:4.6.1.1
IMR:0001354
IMR:0100025
IMR:0200280
KEGG:R00434
KEGG:map00230
event
IEV:0003205
GTP => 3',5'-Cyclic GMP + Pyrophosphate( EC:4.6.1.1 )
EC:1.5.3.1
IMR:0100118
IMR:0200017
IMR:0200189
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:R00610
KEGG:map00260
event
IEV:0003206
Sarcosine + O2 + H2O => Glycine + Formaldehyde + H2O2( EC:1.5.3.1 )
EC:3.1.3.3
IMR:0200102
IMR:0200357
IMR:0200427
IMR:0200453
KEGG:R00582
KEGG:map00260
event
IEV:0003207
L-O-Phospho-serine + H2O => L-Serine + Orthophosphate( EC:3.1.3.3 )
EC:1.5.1.20
IMR:0200030
IMR:0200067
IMR:0200408
IMR:0200463
IMR:0200517
KEGG:R01224
KEGG:map00670
KEGG:map00680
event
IEV:0003208
NADP+ + 5-Methyl-tetrahydro-folic acid => NADPH + 5,10-Methylene-tetrahydro-folic acid( EC:1.5.1.20 )
NADP+ + 5-Methyl-tetrahydro-folic acid => NADPH + 5,10-Methylene-tetrahydro-folic acid + H+( EC:1.5.1.20 )
EC:2.1.3.3
IMR:0200019
IMR:0200102
IMR:0200109
IMR:0200342
KEGG:R01398
KEGG:map00330
event
IEV:0003209
L-Ornithine + Carbamoyl phosphate => L-Citrulline + Orthophosphate( EC:2.1.3.3 )
EC:2.7.1.25
IMR:0001351
IMR:0001360
IMR:0200032
IMR:0200079
KEGG:R00509
KEGG:map00230
KEGG:map00920
event
IEV:0003210
ATP + Adenosine-5'-phospho-sulfate => ADP + 3'-Phospho-adenosine-5'-phospho-sulfate( EC:2.7.1.25 )
EC:3.3.2.6
IMR:0200357
IMR:0200376
IMR:0200461
KEGG:R03057
KEGG:map00590
event
IEV:0003211
Leukotriene A4 + H2O => Leukotriene B4( EC:3.3.2.6 )
EC:1.1.1.205
IMR:0200030
IMR:0200165
IMR:0200221
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R01130
KEGG:map00230
event
IEV:0003212
NAD+ + IMP + H2O => NADH + XMP( EC:1.1.1.205 )
NAD+ + IMP + H2O => NADH + XMP + H+( EC:1.1.1.205 )
EC:2.7.1.60
IMR:0001351
IMR:0001360
IMR:0200282
IMR:0200518
KEGG:R02705
KEGG:map00520
event
IEV:0003213
ATP + N-Acetyl-D-mannosamine => ADP + N-Acetyl-D-mannosamine 6-phosphate( EC:2.7.1.60 )
EC:1.14.13.39
IMR:0100128
IMR:0200019
IMR:0200030
IMR:0200067
IMR:0200217
IMR:0200357
IMR:0200428
IMR:0200463
KEGG:R00557
KEGG:map00330
event
IEV:0003214
NADPH + L-Arginine + O2 = NADP+ + L-Citrulline + NO( EC:1.14.13.39 ):multi-step reaction
3 NADPH + 2 L-Arginine + 4 O2 + 3 H+ = 3 NADP+ + 2 L-Citrulline + 2 Nitric oxide + 4 H2O( EC:1.14.13.39 )
EC:1.3.99.10
IMR:0200158
IMR:0200298
KEGG:C00016
KEGG:C01352
KEGG:R04095
KEGG:map00280
event
IEV:0003215
3-Methyl-butanoyl-CoA + Acceptor => 3-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.10 )
3-Methyl-butanoyl-CoA + FAD => 3-Methylbut-2-enoyl-CoA + FADH2( EC:1.3.99.10 )
EC:3.1.4.11
IMR:0001350
IMR:0100028
IMR:0200076
IMR:0200357
KEGG:R03435
KEGG:mao04070
KEGG:map00562
event
IEV:0003216
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O => D-myo-Inositol 1,4,5-trisphosphate + D-1,2-Diacyl-glycerol( EC:3.1.4.11 )
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O => D-myo-Inositol 1,4,5-trisphosphate + 1,2-Diacyl-sn-glycerol( EC:3.1.4.11 )
EC:6.2.1.1
IMR:0001351
IMR:0200081
IMR:0200083
IMR:0200280
IMR:0200354
IMR:0200484
KEGG:R00925
event
IEV:0003217
two-step reaction:R01354, R00926
CoA + ATP + Propanoic acid => Propanoyl-CoA + AMP + Pyrophosphate( EC:6.2.1.1 )
EC:4.99.1.1
IMR:0200030
IMR:0200089
IMR:0200348
KEGG:C14818
KEGG:R00310
KEGG:map00860
event
IEV:0003218
Protoporphyrin IX + Iron = Protoheme + 2 H+( EC:4.99.1.1 )
Protoporphyrin IX + Fe2+ = Protoheme + 2 H+( EC:4.99.1.1 )
EC:3.6.1.3
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200357
KEGG:R00086
KEGG:map00230
event
IEV:0003219
ATP + H2O => ADP + Orthophosphate( EC:3.6.1.3 )
EC:3.2.2.5
IMR:0200025
IMR:0200134
IMR:0200248
IMR:0200357
KEGG:R00102
KEGG:map00760
event
IEV:0003220
NAD+ + H2O => Nicotinamide + ADP-5-ribose( EC:3.2.2.5 )
NAD+ + H2O => Nicotinamide + ADP-ribose( EC:3.2.2.5 )
EC:5.4.99.7
IMR:0200096
IMR:0200509
KEGG:R03199
KEGG:map00100
event
IEV:0003221
(S)-2,3-Epoxy-squalene = Lanosterol( EC:5.4.99.7 )
EC:2.5.1.21
IMR:0200030
IMR:0200067
IMR:0200273
IMR:0200280
IMR:0200463
IMR:0200481
KEGG:R02872
KEGG:map00100
event
IEV:0003222
NADPH + Presqualene diphosphate => NADP+ + Squalene + Pyrophosphate( EC:2.5.1.21 )
NADPH + Presqualene diphosphate + H+ => NADP+ + Squalene + Pyrophosphate( EC:2.5.1.21 )
EC:1.5.99.2
IMR:0200017
IMR:0200047
IMR:0200189
IMR:0200224
IMR:0200300
IMR:0200357
KEGG:R01565
KEGG:map00260
event
IEV:0003223
N,N-Dimethyl-glycine + H2O + Acceptor => Sarcosine + Formaldehyde + Reduced acceptor( EC:1.5.99.2 )
EC:3.5.4.6
IMR:0200075
IMR:0200083
IMR:0200221
IMR:0200357
KEGG:R00181
KEGG:map00230
event
IEV:0003224
AMP + H2O => IMP + NH3( EC:3.5.4.6 )
EC:6.3.4.16
IMR:0001351
IMR:0001360
IMR:0200075
IMR:0200102
IMR:0200109
IMR:0200324
IMR:0200357
KEGG:R00149
KEGG:map00250
KEGG:map00330
KEGG:map00910
event
IEV:0003225
2 ATP + CO2 + NH3 + H2O => 2 ADP + Carbamoyl phosphate + Orthophosphate( EC:6.3.4.16 )
EC:1.4.3.4
IMR:0200075
IMR:0200217
IMR:0200325
IMR:0200357
IMR:0200401
IMR:0200487
KEGG:R04674
KEGG:map00340
event
IEV:0003226
N-Methyl-histamine + H2O + O2 => 3-Methyl-imidazole acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
N-Methyl-histamine + H2O + O2 => Methylimidazole acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:2.7.1.68
IMR:0001350
IMR:0001351
IMR:0001360
IMR:0200496
KEGG:R03469
KEGG:map00562
KEGG:map04070
event
IEV:0003227
ATP + 1-Phosphatidyl-1D-myo-inositol 4-phosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate( EC:2.7.1.68 )
EC:1.14.99.1
IMR:0200212
IMR:0200217
IMR:0200497
KEGG:R01590
KEGG:map00590
event
IEV:0003228
Arachidonic acid + 2 O2 + Reduced acceptor => Prostaglandin G2 + Acceptor( EC:1.14.99.1 ):subsequently IEV:0003091
Arachidonic acid + 2 O2 => Prostaglandin G2( EC:1.14.99.1 )
EC:5.3.99.2
IMR:0200253
IMR:0200457
KEGG:R02266
KEGG:map00590
event
IEV:0003229
Prostaglandin H2 => Prostaglandin D2( EC:5.3.99.2 )
EC:4.4.1.1
IMR:0200075
IMR:0200331
IMR:0200357
IMR:0200467
IMR:0200514
KEGG:R00782
KEGG:map00270
event
IEV:0003230
L-Cysteine + H2O => Pyruvic acid + Hydrogen sulfide + NH3( EC:4.4.1.1 )
EC:2.7.1.40
IMR:0200223
IMR:0200286
IMR:0200331
IMR:0200365
KEGG:R01858
KEGG:map00230
event
IEV:0003232
dGDP + Phosphoenol-pyruvic acid => dGTP + Pyruvic acid( EC:2.7.1.40 )
EC:1.1.1.184
IMR:0200030
IMR:0200051
IMR:0200067
IMR:0200146
IMR:0200463
KEGG:R02581
KEGG:map00590
event
IEV:0003233
NADPH + Prostaglandin E2 => NADP+ + Prostaglandin F2alpha( EC:1.1.1.184 )
NADPH + Prostaglandin E2 + H+ => NADP+ + Prostaglandin F2alpha( EC:1.1.1.184 )
EC:6.3.4.2
IMR:0001351
IMR:0001360
IMR:0200075
IMR:0200102
IMR:0200199
IMR:0200202
KEGG:R00571
KEGG:map00240
event
IEV:0003234
ATP + UTP + NH3 => ADP + CTP + Orthophosphate( EC:6.3.4.2 )
EC:3.6.1.23
IMR:0200008
IMR:0200056
IMR:0200280
IMR:0200357
KEGG:R02100
KEGG:map00240
event
IEV:0003235
dUTP + H2O => dUMP + Pyrophosphate( EC:3.6.1.23 )
EC:1.13.11.11
IMR:0200038
IMR:0200217
IMR:0200307
KEGG:R00678
KEGG:map00380
event
IEV:0003236
L-Tryptophan + O2 => N-Formyl-L-kynurenine( EC:1.13.11.11 )
EC:6.3.4.5
IMR:0001351
IMR:0200019
IMR:0200083
IMR:0200280
IMR:0200391
IMR:0200459
KEGG:R01954
KEGG:map00250
KEGG:map00330
event
IEV:0003237
ATP + L-Aspartic acid + L-Citrulline => AMP + Pyrophosphate + L-Arginino-succinic acid( EC:6.3.4.5 )
EC:3.6.1.19
IMR:0200280
IMR:0200286
IMR:0200357
IMR:0200505
KEGG:R01855
KEGG:map00230
event
IEV:0003238
dGTP + H2O => dGMP + Pyrophosphate( EC:3.6.1.19 )
EC:3.6.1.19
IMR:0200122
IMR:0200280
IMR:0200357
IMR:0200446
KEGG:R03531
KEGG:map00230
event
IEV:0003239
dITP + H2O => dIMP + Pyrophosphate( EC:3.6.1.19 )
EC:6.3.4.3
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200110
IMR:0200330
IMR:0200347
KEGG:R00943
KEGG:map00630
KEGG:map00670
event
IEV:0003240
ATP + L-Tetrahydro-folic acid + Formic acid => ADP + 10-Formyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.4.3 )
ATP + Tetrahydrofolate + Formic acid => ADP + 10-Formyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.4.3 )
EC:3.6.1.5
IMR:0200102
IMR:0200187
IMR:0200338
IMR:0200357
KEGG:R02092
KEGG:map00240
event
IEV:0003241
dTDP + H2O => dTMP + Orthophosphate( EC:3.6.1.5 )
EC:6.3.2.17
IMR:0001351
IMR:0001360
IMR:0100119
IMR:0200102
IMR:0200176
IMR:0200185
KEGG:R02237
KEGG:map00790
event
IEV:0003242
ATP + 7,8-Dihydro-pteroic acid + L-Glutamic acid => ADP + 7,8-Dihydro-folic acid + Orthophosphate( EC:6.3.2.17 )
EC:2.5.1.16
IMR:0200028
IMR:0200153
IMR:0200175
IMR:0200285
KEGG:R01920
KEGG:map00270
KEGG:map00330
KEGG:map00480
event
IEV:0003243
S-Adenosyl-L-methioninamine + Putrescine => 5'-Methylthio-adenosine + Spermidine( EC:2.5.1.16 )
S-Adenosylmethioninamine + Putrescine => 5'-Methylthio-adenosine + Spermidine( EC:2.5.1.16 )
EC:2.7.1.35
IMR:0001351
IMR:0001360
IMR:0200309
IMR:0200382
KEGG:R02493
KEGG:map00750
event
IEV:0003244
ATP + Pyridoxamine => ADP + Pyridoxamine 5'-phosphate( EC:2.7.1.35 )
EC:2.7.1.1
IMR:0001351
IMR:0001360
IMR:0200053
IMR:0200230
KEGG:R01326
KEGG:map00051
KEGG:map00520
event
IEV:0003245
ATP + D-Mannose => ADP + D-Mannose 6-phosphate( EC:2.7.1.1 )
EC:1.2.3.1
IMR:0200217
IMR:0200267
IMR:0200357
IMR:0200487
IMR:0200504
KEGG:R01709
KEGG:map00750
event
IEV:0003246
Pyridoxal + O2 + H2O => 4-Pyridoxic acid + H2O2( EC:1.2.3.1 )
EC:1.17.4.1
IMR:0200098
IMR:0200108
IMR:0200133
IMR:0200206
IMR:0200357
KEGG:R02018
KEGG:map00240
event
IEV:0003247
UDP + Reduced thioredoxin => dUDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
EC:1.1.1.49
IMR:0200030
IMR:0200067
IMR:0200463
IMR:0200508
KEGG:C01172
KEGG:R02736
KEGG:map00030
KEGG:map00480
event
IEV:0003248
NADP+ + D-Glucose 6-phosphate => NADPH + D-6-Phospho-glucono 1,5-lactone( EC:1.1.1.49 )
NADP+ + beta-D-Glucose 6-phosphate => NADPH + D-Glucono-1,5-lactone 6-phosphate + H+( EC:1.1.1.49 )
EC:2.7.7.43
IMR:0200020
IMR:0200107
IMR:0200202
IMR:0200280
KEGG:R01117
KEGG:map00520
event
IEV:0003249
CTP + N-Acetyl-neuraminic acid => Pyrophosphate + CMP-N-acetyl-neuraminic acid( EC:2.7.7.43 )
EC:6.1.1.11
IMR:0001351
IMR:0200083
IMR:0200268
IMR:0200280
IMR:0200379
IMR:0200453
KEGG:R03662
KEGG:map00970
event
IEV:0003250
ATP + L-Serine + tRNA(Ser) => AMP + L-Seryl-tRNA(Ser) + Pyrophosphate( EC:6.1.1.11 )
EC:1.4.3.3
IMR:0100118
IMR:0200075
IMR:0200184
IMR:0200217
IMR:0200357
IMR:0200487
KEGG:R00366
KEGG:map00260
event
IEV:0003251
Glycine + H2O + O2 => Glyoxylic acid + NH3 + H2O2( EC:1.4.3.3 )
EC:2.1.1.6
IMR:0100115
IMR:0200054
IMR:0200151
IMR:0200388
KEGG:R02534
KEGG:map00350
event
IEV:0003252
S-Adenosyl-L-methionine + L-Noradrenaline => S-Adenosyl-L-homocysteine + L-Normetanephrine( EC:2.1.1.6 )
EC:1.4.3.4
IMR:0100123
IMR:0200075
IMR:0200217
IMR:0200353
IMR:0200357
IMR:0200487
KEGG:R02908
KEGG:map00380
event
IEV:0003253
Serotonin + H2O + O2 => 5-Hydroxy-indole-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:2.1.1.6
IMR:0100113
IMR:0200009
IMR:0200054
IMR:0200151
KEGG:R04301
KEGG:map00350
KEGG:map00965
event
IEV:0003254
S-Adenosyl-L-methionine + Dopamine => S-Adenosyl-L-homocysteine + 3-Methoxy-tyramine( EC:2.1.1.6 )
EC:3.6.1.5
IMR:0001360
IMR:0200083
IMR:0200102
IMR:0200357
KEGG:R00122
KEGG:map00230
event
IEV:0003255
ADP + H2O => AMP + Orthophosphate( EC:3.6.1.5 )
EC:4.6.1.1
IMR:0001351
IMR:0100024
IMR:0200280
KEGG:R00089
KEGG:map00230
event
IEV:0003256
ATP => 3',5'-Cyclic AMP + Pyrophosphate( EC:4.6.1.1 )
EC:4.2.1.22
IMR:0200039
IMR:0200220
IMR:0200357
IMR:0200453
KEGG:R01290
KEGG:map00260
KEGG:map00270
event
IEV:0003257
L-Homocysteine + L-Serine => L-Cystathionine + H2O( EC:4.2.1.22 )
EC:1.5.1.3
IMR:0200030
IMR:0200067
IMR:0200185
IMR:0200330
IMR:0200463
KEGG:R00939
KEGG:map00670
KEGG:map00790
event
IEV:0003258
NADPH + 7,8-Dihydro-folic acid => NADP+ + L-Tetrahydro-folic acid( EC:1.5.1.3 )
NADPH + 7,8-Dihydro-folic acid + H+ => NADP+ + Tetrahydrofolate( EC:1.5.1.3 )
EC:2.7.1.1
IMR:0001351
IMR:0001360
KEGG:C00221
KEGG:C01172
KEGG:R01600
KEGG:map00010
event
IEV:0003259
ATP + D-Glucose => ADP + D-Glucose 6-phosphate( EC:2.7.1.1 )
ATP + beta-D-Glucose => ADP + beta-D-Glucose 6-phosphate( EC:2.7.1.1 )
EC:1.4.3.5
IMR:0200075
IMR:0200217
IMR:0200229
IMR:0200309
IMR:0200357
IMR:0200487
KEGG:R00277
KEGG:map00750
event
IEV:0003260
Pyridoxamine 5'-phosphate + O2 + H2O => Pyridoxal 5'-phosphate + H2O2 + NH3( EC:1.4.3.5 )
EC:3.6.1.5
IMR:0001354
IMR:0001357
IMR:0200102
IMR:0200357
KEGG:R00335
KEGG:map00230
event
IEV:0003261
GTP + H2O => GDP + Orthophosphate( EC:3.6.1.5 )
EC:1.14.17.1
IMR:0100113
IMR:0100115
IMR:0200196
IMR:0200217
IMR:0200293
IMR:0200357
KEGG:R02535
KEGG:map00350
event
IEV:0003262
Dopamine + L-Ascorbic acid + O2 => L-Noradrenaline + L-Dehydro-ascorbic acid + H2O( EC:1.14.17.1 )
EC:6.1.1.21
IMR:0001351
IMR:0200083
IMR:0200106
IMR:0200135
IMR:0200137
IMR:0200280
KEGG:R03655
KEGG:map00970
event
IEV:0003263
ATP + L-Histidine + tRNA(His) => AMP + L-Histidyl-tRNA(His) + Pyrophosphate( EC:6.1.1.21 )
EC:1.5.1.12
IMR:0200030
IMR:0200091
IMR:0200225
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R04444
KEGG:map00330
event
IEV:0003264
NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + 2 H2O => NADH + L-erythro-4-Hydroxy-glutamic acid( EC:1.5.1.12 )
NAD+ + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + 2 H2O => NADH + L-erythro-4-Hydroxy-glutamic acid + H+( EC:1.5.1.12 )
EC:4.1.1.37
IMR:0200258
IMR:0200315
IMR:0200324
KEGG:R03197
KEGG:map00860
event
IEV:0003265
Uroporphyrinogen III => Coproporphyrinogen III + 4 CO2( EC:4.1.1.37 )
EC:2.7.1.59
IMR:0001351
IMR:0001360
IMR:0200259
IMR:0200374
KEGG:R01201
KEGG:map00520
event
IEV:0003266
ATP + N-Acetyl-D-glucosamine => ADP + N-Acetyl-D-glucosamine 6-phosphate( EC:2.7.1.59 )
EC:1.5.1.3
IMR:0200030
IMR:0200067
IMR:0200330
IMR:0200356
IMR:0200463
KEGG:R00940
KEGG:map00790
event
IEV:0003267
NADPH + Folic acid => NADP+ + L-Tetrahydro-folic acid( EC:1.5.1.3 ):two-step reaction
2 NADPH + Folic acid + 2 H+ => 2 NADP+ + Tetrahydrofolate( EC:1.5.1.3 )
EC:1.17.3.2
IMR:0200029
IMR:0200217
IMR:0200357
IMR:0200439
IMR:0200487
KEGG:R02107
KEGG:map00230
event
IEV:0003268
Xanthine + H2O + O2 => Uric acid + H2O2( EC:1.17.3.2 )
EC:2.1.1.20
IMR:0100118
IMR:0200054
IMR:0200151
IMR:0200189
KEGG:R00367
KEGG:map00260
event
IEV:0003269
S-Adenosyl-L-methionine + Glycine => S-Adenosyl-L-homocysteine + Sarcosine( EC:2.1.1.20 )
EC:2.1.2.2
IMR:0200022
IMR:0200252
IMR:0200330
IMR:0200347
KEGG:R04325
KEGG:map00230
KEGG:map00670
event
IEV:0003270
10-Formyl-tetrahydro-folic acid + 5'-Phospho-ribosyl-glycinamide => L-Tetrahydro-folic acid + 5'-Phospho-ribosyl-N-formyl-glycinamide( EC:2.1.2.2 )
10-Formyl-tetrahydro-folic acid + 5'-Phospho-ribosyl-glycinamide => Tetrahydrofolate + 5'-Phospho-ribosyl-N-formyl-glycinamide( EC:2.1.2.2 )
EC:1.13.11.27
IMR:0200217
IMR:0200254
IMR:0200324
IMR:0200341
KEGG:R02521
KEGG:map00130
KEGG:map00350
event
IEV:0003271
4-Hydroxy-phenyl-pyruvic acid + O2 => CO2 + 2,5-Dihydroxy-phenyl-acetic acid( EC:1.13.11.27 )
EC:3.1.3.5
IMR:0200102
IMR:0200160
IMR:0200226
IMR:0200357
KEGG:R02088
KEGG:map00230
event
IEV:0003272
dAMP + H2O => Deoxy-adenosine + Orthophosphate( EC:3.1.3.5 )
EC:2.5.1.6
IMR:0001351
IMR:0200054
IMR:0200102
IMR:0200280
IMR:0200357
IMR:0200488
KEGG:R00177
KEGG:map00270
event
IEV:0003273
ATP + L-Methionine + H2O => S-Adenosyl-L-methionine + Pyrophosphate + Orthophosphate( EC:2.5.1.6 )
IMR:0200324
IMR:0200360
KEGG:C03508
KEGG:R03758
KEGG:map00260
event
IEV:0003274
L-2-Amino-3-oxo-butanoic acid => Amino-acetone + CO2( nonenzymatic )
EC:2.5.1.57
IMR:0200102
IMR:0200223
IMR:0200279
IMR:0200357
IMR:0200518
KEGG:R04435
KEGG:map00520
event
IEV:0003275
N-Acetyl-D-mannosamine 6-phosphate + Phosphoenol-pyruvic acid + H2O => N-Acetyl-neuraminate 9-phosphate + Orthophosphate( EC:2.5.1.57 )
EC:1.4.3.4
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200360
IMR:0200471
IMR:0200487
KEGG:R02529
KEGG:map00260
event
IEV:0003276
Amino-acetone + H2O + O2 => Methyl-glyoxal + NH3 + H2O2( EC:1.4.3.4 )
EC:5.1.3.14
IMR:0200162
IMR:0200247
KEGG:R00420
KEGG:map00520
event
IEV:0003277
UDP-N-acetyl-D-glucosamine => UDP-N-acetyl-D-mannosamine( EC:5.1.3.14 )
EC:1.1.1.31
IMR:0200030
IMR:0200248
IMR:0200297
IMR:0200385
IMR:0200521
KEGG:R05066
KEGG:map00280
event
IEV:0003278
NADH + (S)-Methyl-malonate semialdehyde => NAD+ + (S)-3-Hydroxy-2-methyl-propanoic acid( EC:1.1.1.31 )
NADH + (S)-Methyl-malonate semialdehyde + H+ => NAD+ + (S)-3-Hydroxyisobutyrate( EC:1.1.1.31 )
EC:1.2.1.3
IMR:0200030
IMR:0200163
IMR:0200248
IMR:0200297
IMR:0200357
IMR:0200521
KEGG:R03869
KEGG:map00280
event
IEV:0003279
NAD+ + (S)-Methyl-malonate semialdehyde + H2O => NADH + Methyl-malonic acid( EC:1.2.1.3 )
NAD+ + (S)-Methyl-malonate semialdehyde + H2O => NADH + Methyl-malonic acid + H+( EC:1.2.1.3 )
EC:1.5.1.7
IMR:0200030
IMR:0200140
IMR:0200155
IMR:0200248
IMR:0200357
IMR:0200480
IMR:0200521
KEGG:R00715
KEGG:map00300
KEGG:map00310
event
IEV:0003280
NADH + L-Lysine + 2-Oxo-glutaric acid => NAD+ + L-Saccharopine + H2O( EC:1.5.1.7 )
NADH + L-Lysine + 2-Oxo-glutaric acid + H+ => NAD+ + L-Saccharopine + H2O( EC:1.5.1.7 )
EC:3.2.2.5
IMR:0200025
IMR:0200067
IMR:0200314
IMR:0200357
KEGG:R00119
KEGG:map00760
event
IEV:0003281
NADP+ + H2O => Nicotinamide + ADPribose 2'-phosphate( EC:3.2.2.5 )
EC:1.4.3.4
IMR:0200009
IMR:0200075
IMR:0200217
IMR:0200357
IMR:0200383
IMR:0200487
KEGG:R04890
KEGG:map00350
event
IEV:0003282
3-Methoxy-tyramine + H2O + O2 => 3-methoxy-4-hydroxy-phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
EC:4.2.3.12
IMR:0200063
IMR:0200358
IMR:0200406
KEGG:R04286
KEGG:map00790
event
IEV:0003283
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydro-pteridine triphosphate => 6-Pyruvoyl-5,6,7,8-tetrahydro-pterin + Triphosphate( EC:4.2.3.12 )
EC:2.6.1.52
IMR:0100119
IMR:0200181
IMR:0200257
IMR:0200480
KEGG:R05085
KEGG:map00750
event
IEV:0003284
2-Oxo-glutaric acid + O-Phospho-4-hydroxy-L-threonine = L-Glutamic acid + 2-Oxo-3-hydroxy-4-phospho-butanoic acid( EC:2.6.1.52 )
EC:2.5.1.1
IMR:0200094
IMR:0200280
IMR:0200287
IMR:0200399
KEGG:R01658
KEGG:map00900
event
IEV:0003285
Isopentenyl diphosphate + Dimethylallyl diphosphate => Geranyl diphosphate + Pyrophosphate( EC:2.5.1.1 )
EC:3.6.1.17
IMR:0200165
IMR:0200357
IMR:0200425
IMR:0200490
KEGG:R02805
KEGG:map00230
event
IEV:0003286
P1,P4-Bis(5'-xanthosyl) tetraphosphate + H2O => XTP + XMP( EC:3.6.1.17 )
EC:3.6.1.19
IMR:0001354
IMR:0200280
IMR:0200292
IMR:0200357
KEGG:R00426
KEGG:map00230
event
IEV:0003287
GTP + H2O => GMP + Pyrophosphate( EC:3.6.1.19 )
EC:1.5.1.12
IMR:0100119
IMR:0200030
IMR:0200205
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R00245
KEGG:map00330
event
IEV:0003288
NAD+ + L-Glutamate 5-semialdehyde + H2O => NADH + L-Glutamic acid( EC:1.5.1.12 )
NAD+ + L-Glutamate 5-semialdehyde + H2O => NADH + L-Glutamic acid + H+( EC:1.5.1.12 )
EC:1.2.3.1
IMR:0200052
IMR:0200217
IMR:0200353
IMR:0200357
IMR:0200487
KEGG:R04904
KEGG:map00380
event
IEV:0003289
5-Hydroxy-indole-acetaldehyde + H2O + O2 => 5-Hydroxy-indole-acetic acid + H2O2( EC:1.2.3.1 )
EC:4.3.1.3
IMR:0200075
IMR:0200137
IMR:0200337
KEGG:R01168
KEGG:map00340
KEGG:map00910
event
IEV:0003290
L-Histidine = Urocanic acid + NH3( EC:4.3.1.3 )
EC:4.1.1.15
IMR:0100117
IMR:0100119
IMR:0200324
KEGG:R00261
KEGG:map00250
KEGG:map00650
event
IEV:0003291
L-Glutamic acid => 4-Amino-butanoic acid + CO2( EC:4.1.1.15 )
EC:3.1.3.5
IMR:0200005
IMR:0200102
IMR:0200357
IMR:0200390
KEGG:R01664
KEGG:map00240
event
IEV:0003292
dCMP + H2O => Deoxy-cytidine + Orthophosphate( EC:3.1.3.5 )
EC:6.3.2.6
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200213
IMR:0200422
IMR:0200459
KEGG:R04591
KEGG:map00230
event
IEV:0003293
ATP + 5'-Phospho-ribosyl-5-amino-imidazole-4-carboxylic acid + L-Aspartic acid => ADP + 5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole + Orthophosphate( EC:6.3.2.6 )
ATP + 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate + L-Aspartic acid => ADP + 5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole + Orthophosphate( EC:6.3.2.6 )
EC:3.1.3.-
IMR:0200067
IMR:0200102
IMR:0200248
IMR:0200357
KEGG:R00118
KEGG:map00760
event
IEV:0003294
NADP+ + H2O => NAD+ + Orthophosphate( EC:3.1.3.- )
EC:2.8.1.2
IMR:0200007
IMR:0200331
KEGG:C00094
KEGG:C00320
KEGG:R03105
KEGG:map00270
event
IEV:0003295
3-Mercapto-pyruvic acid + Hydrogen cyanide => Pyruvic acid + Thiocyanic acid( EC:2.8.1.2 )
3-Mercapto-pyruvic acid + Sulfite => Pyruvic acid + Thiosulfate( EC:2.8.1.2 )
EC:3.4.13.20
IMR:0200137
IMR:0200178
IMR:0200357
IMR:0200438
KEGG:R01166
KEGG:map00340
KEGG:map00410
event
IEV:0003296
L-Carnosine + H2O => L-Histidine + beta-Alanine( EC:3.4.13.20 )
Carnosine + H2O => L-Histidine + beta-Alanine( EC:3.4.13.20 )
EC:2.7.1.127
IMR:0001351
IMR:0001360
IMR:0100028
IMR:0100029
KEGG:R03433
KEGG:map00562
KEGG:map04070
event
IEV:0003297
ATP + 1D-myo-Inositol 1,4,5-trisphosphate => ADP + 1D-myo-Inositol 1,3,4,5-tetrakisphosphate( EC:2.7.1.127 )
EC:6.1.1.12
IMR:0001351
IMR:0200006
IMR:0200083
IMR:0200249
IMR:0200280
IMR:0200459
KEGG:R05577
KEGG:map00970
event
IEV:0003298
ATP + L-Aspartic acid + tRNA(Asp) => AMP + L-Aspartyl-tRNA(Asp) + Pyrophosphate( EC:6.1.1.12 )
EC:2.7.1.21
IMR:0001351
IMR:0001360
IMR:0200187
IMR:0200384
KEGG:R01567
KEGG:map00240
event
IEV:0003299
ATP + Thymidine => ADP + dTMP( EC:2.7.1.21 )
EC:3.1.3.57
IMR:0200102
IMR:0200124
IMR:0200334
IMR:0200357
KEGG:R03427
KEGG:map00562
KEGG:map04070
event
IEV:0003300
1D-myo-Inositol 1,3,4-trisphosphate + H2O => 1D-myo-Inositol 3,4-bisphosphate + Orthophosphate( EC:3.1.3.57 )
EC:3.6.1.5
IMR:0200102
IMR:0200202
IMR:0200357
IMR:0200468
KEGG:R00569
KEGG:map00240
event
IEV:0003301
CTP + H2O => CDP + Orthophosphate( EC:3.6.1.5 )
EC:1.2.1.3
IMR:0200030
IMR:0200248
IMR:0200321
IMR:0200352
IMR:0200357
IMR:0200521
KEGG:R04065
KEGG:map00340
event
IEV:0003302
NAD+ + Imidazole-4-acetaldehyde + H2O = NADH + Imidazole-4-acetic acid( EC:1.2.1.3 )
NAD+ + Imidazole-4-acetaldehyde + H2O = NADH + Imidazole-4-acetic acid + H+( EC:1.2.1.3 )
EC:4.1.1.65
IMR:0001358
IMR:0200317
IMR:0200324
KEGG:R02055
KEGG:map00564
event
IEV:0003303
O-Phosphatidyl-L-serine => Phosphatidyl-ethanolamine + CO2( EC:4.1.1.65 )
Phosphatidylserine => Phosphatidyl-ethanolamine + CO2( EC:4.1.1.65 )
EC:3.1.3.5
IMR:0200102
IMR:0200194
IMR:0200221
IMR:0200357
KEGG:R01126
KEGG:map00230
event
IEV:0003304
IMP + H2O => Inosine + Orthophosphate( EC:3.1.3.5 )
EC:1.4.3.1
IMR:0200075
IMR:0200126
IMR:0200217
IMR:0200339
IMR:0200357
IMR:0200487
KEGG:R00359
KEGG:map00250
event
IEV:0003305
D-Aspartic acid + H2O + O2 => Oxaloacetic acid + NH3 + H2O2( EC:1.4.3.1 )
EC:6.3.3.2
IMR:0001351
IMR:0001360
IMR:0200030
IMR:0200102
IMR:0200159
IMR:0200512
KEGG:R02301
KEGG:map00670
event
IEV:0003306
ATP + 5-Formyl-tetrahydro-folic acid => ADP + 5,10-Methenyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.3.2 )
ATP + 5-Formyl-tetrahydro-folic acid + H+ => ADP + 5,10-Methenyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.3.2 )
EC:3.6.1.5
IMR:0200084
IMR:0200102
IMR:0200338
IMR:0200357
KEGG:R02095
KEGG:map00240
event
IEV:0003307
dTTP + H2O => dTDP + Orthophosphate( EC:3.6.1.5 )
EC:4.1.1.50
IMR:0200030
IMR:0200054
IMR:0200285
IMR:0200324
KEGG:R00178
KEGG:map00270
KEGG:map00330
event
IEV:0003308
S-Adenosyl-L-methionine => S-Adenosyl-L-methioninamine + CO2( EC:4.1.1.50 )
S-Adenosyl-L-methionine + H+ => S-Adenosylmethioninamine + CO2( EC:4.1.1.50 )
EC:2.1.1.1
IMR:0200025
IMR:0200030
IMR:0200054
IMR:0200151
IMR:0200188
KEGG:R01269
KEGG:map00760
event
IEV:0003309
S-Adenosyl-L-methionine + Nicotinamide => S-Adenosyl-L-homocysteine + 1-Methyl-nicotinamide( EC:2.1.1.1 )
S-Adenosyl-L-methionine + Nicotinamide + H+ => S-Adenosyl-L-homocysteine + 1-Methyl-nicotinamide( EC:2.1.1.1 )
EC:2.7.1.36
IMR:0001351
IMR:0001360
IMR:0200118
IMR:0200139
KEGG:R02245
KEGG:map00900
event
IEV:0003310
ATP + (R)-Mevalonic acid => ADP + (R)-Mevalonic acid 5-phosphate( EC:2.7.1.36 )
EC:6.4.1.2
IMR:0001351
IMR:0001360
IMR:0200102
IMR:0200414
IMR:0200464
KEGG:C00288
KEGG:R00742
KEGG:map00253
KEGG:map00620
KEGG:map00640
event
IEV:0003311
ATP + Acetyl-CoA + CO2 + H2O = ADP + Malonyl-CoA + Orthophosphate( EC:6.4.1.2 )
ATP + Acetyl-CoA + HCO3- = ADP + Malonyl-CoA + Orthophosphate( EC:6.4.1.2 )
EC:1.5.1.5
IMR:0200067
IMR:0200159
IMR:0200463
IMR:0200517
KEGG:R01220
KEGG:map00630
KEGG:map00670
event
IEV:0003312
NADP+ + 5,10-Methylene-tetrahydro-folic acid = NADPH + 5,10-Methenyl-tetrahydro-folic acid( EC:1.5.1.5 )
true
EC:2.3.1.57
IMR:0200354
IMR:0200414
KEGG:C02297
KEGG:C03687
KEGG:R03910
event
IEV:0003314
Acetyl-CoA + alkane-alpha,omega-diamine = CoA + N-acetyldiamine( EC:2.3.1.57 )
EC:2.3.1.87
IMR:0200354
IMR:0200414
KEGG:C15534
KEGG:C15535
KEGG:R03760
event
IEV:0003315
Acetyl-CoA + 2-arylethylamine = CoA + N-acetyl-2-arylethylamine( EC:2.3.1.87 )
EC:3.6.1.6
IMR:0200102
IMR:0200206
IMR:0200357
IMR:0200409
KEGG:R00155
KEGG:map00240
event
IEV:0003316
UDP + H2O => UMP + Orthophosphate( EC:3.6.1.6 )
EC:3.6.1.6
IMR:0001357
IMR:0200102
IMR:0200292
IMR:0200357
KEGG:R00328
KEGG:map00230
event
IEV:0003317
GDP + H2O => GMP + Orthophosphate( EC:3.6.1.6 )
EC:3.6.1.6
IMR:0200102
IMR:0200221
IMR:0200357
IMR:0200511
KEGG:R00961
KEGG:map00230
event
IEV:0003318
IDP + H2O => IMP + Orthophosphate( EC:3.6.1.5 )
EC:4.1.1.29
IMR:0100120
IMR:0200324
IMR:0200417
KEGG:R01682
KEGG:map00430
event
IEV:0003319
L-Cysteic acid => Taurine + CO2( EC:4.1.1.29 )
EC:4.1.1.15
IMR:0200305
IMR:0200324
IMR:0200402
KEGG:R02466
KEGG:map00430
event
IEV:0003320
L-Cysteine-sulfinic acid => Hypotaurine + CO2( EC:4.1.1.15 )
EC:1.2.1.3
IMR:0100117
IMR:0200030
IMR:0200142
IMR:0200248
IMR:0200357
IMR:0200521
KEGG:R02549
KEGG:map00330
KEGG:map00410
event
IEV:0003321
NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid( EC:1.2.1.3 )
NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid + H+( EC:1.2.1.3 )
EC:1.3.99.2
IMR:0200164
IMR:0200174
IMR:0200224
IMR:0200300
KEGG:R02661
KEGG:map00280
event
IEV:0003322
2-Methyl-propanoyl-CoA + Acceptor = 2-Methylprop-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
EC:2.4.2.8
IMR:0200083
IMR:0200179
IMR:0200280
IMR:0200350
KEGG:R00190
KEGG:map00230
event
IEV:0003323
AMP + Pyrophosphate = Adenine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
AMP + Pyrophosphate = Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
EC:2.4.2.8
IMR:0200179
IMR:0200280
IMR:0200292
IMR:0200319
KEGG:R01229
KEGG:map00230
event
IEV:0003324
GMP + Pyrophosphate = Guanine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
GMP + Pyrophosphate = Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
EC:2.6.1.1
IMR:0100119
IMR:0200274
IMR:0200380
IMR:0200480
KEGG:R00694
KEGG:map00360
KEGG:map00400
event
IEV:0003325
2-Oxo-glutaric acid + L-Phenylalanine = L-Glutamic acid + Phenyl-pyruvic acid( EC:2.6.1.1 )
EC:4.2.1.3
IMR:0200023
IMR:0200473
KEGG:R01324
event
IEV:0003326
two-step reaction
Citric acid = Isocitric acid( EC:4.2.1.3 )
EC:2.7.4.6
IMR:0001351
IMR:0001360
KEGG:R00124
KEGG:map00230
event
IEV:0003327
ATP + ADP = ADP + ATP( EC:2.7.4.6 )
OBSOLETE: remap to 'FGF8 signaling pathway' IEV:0003405.
event
IEV:0003328
FGF8 signaling pathway(Xenopus)
true
OBSOLETE: remap to 'FGF8 signaling pathway' IEV:0003405.
XX:<new dbxref>
OBSOLETE: remap to 'FGF8 signaling pathway' IEV:0003405.
event
IEV:0003329
FGF8 signaling pathway(Mouse)
true
OBSOLETE: remap to 'FGF8 signaling pathway' IEV:0003405.
XX:<new dbxref>
IMR:0002055
IMR:0100558
event
IEV:0003330
Binding of FGF8 and FGFR1 in extracellular
IMR:0002055
IMR:0100558
event
IEV:0003331
FGF8:FGFR1 dimerization in plasma membrane
IMR:0002055
event
IEV:0003332
Autophosphorylation of FGFR1 in plasma membrane
IMR:0001836
IMR:0002055
event
IEV:0003333
Binding of FGFR1_p and FRS2 in cytosol
IMR:0001836
IMR:0002055
event
IEV:0003334
Phosphorylation of FRS2 by FGFR1_p in cytosol
IMR:0000227
IMR:0000399
IMR:0000400
event
IEV:0003335
Phosphorylation of ETS1/2 by ERK1/2_p in inner space of nucleus
IGS:0000028
IMR:0000399
IMR:0000400
event
IEV:0003336
Binding of ETS1/2_p and responsive element in inner space of nucleus
IMR:0000397
event
IEV:0003337
Transcription of ETS target gene in nucleus
IMR:0002082
event
IEV:0003338
Negative feedback regulation of FGF8 signaling by Sprouty2
IMR:0000340
IMR:0002082
event
IEV:0003339
Binding of Grb2 and Sprouty2 in cytosol
IMR:0002055
IMR:0002082
event
IEV:0003340
Phosphorylation of Sprouty2 by FGFR1 in cytosol
IMR:0000399
IMR:0000400
IMR:0002082
event
IEV:0003341
Gene expression of Sprouty2 by ETS1/2
IMR:0002082
event
IEV:0003342
Translation of Sprouty2 in cytosol
IMR:0002082
event
IEV:0003343
Nuclear export of mRNA (Sprouty2)
IMR:0002082
event
IEV:0003344
Transcription of Sprouty2 gene in nucleus
IMR:0002086
event
IEV:0003345
Negative feedback regulation of FGF8 signaling by Sef
IMR:0002055
IMR:0002086
event
IEV:0003346
Binding of FGFR1 and Sef in cytosol
IMR:0000399
IMR:0000400
IMR:0002086
event
IEV:0003347
Gene expression of Sef by ETS1/2
IMR:0002086
event
IEV:0003348
Transcription of Sef gene in nucleus
IMR:0002086
event
IEV:0003349
Nuclear export of mRNA (Sef)
IMR:0002086
event
IEV:0003350
Translation of Sef in cytosol
IMR:0100235
event
IEV:0003351
Negative feedback regulation of FGF8 signaling by Mkp3
IMR:0000227
IMR:0100235
event
IEV:0003352
Binding of ERK1/2_p and Mkp3 in cytosol
IMR:0000399
IMR:0000400
IMR:0100235
PubMed:18321244
event
IEV:0003353
Gene expression of Mkp3 by ETS1/2
IMR:0100235
event
IEV:0003354
Transcription of Mkp3 gene in nucleus
IMR:0100235
event
IEV:0003355
Nuclear export of mRNA (Mkp3)
IMR:0100235
event
IEV:0003356
Translation of Mkp3 in cytosol
IMR:0002081
event
IEV:0003357
Negative feedback regulation of FGF8 signaling by Sprouty1
IMR:0000340
IMR:0002081
event
IEV:0003358
Binding of Grb2 and Sprouty1_p in cytosol
IMR:0002055
IMR:0002081
event
IEV:0003359
Phosphorylation of Sprouty1 by FGFR1 in cytosol
IMR:0000399
IMR:0000400
IMR:0002081
event
IEV:0003360
Gene expression of Sprouty1 by ETS1/2
IMR:0002081
event
IEV:0003361
Transcription of Sprouty1 gene in nucleus
IMR:0002081
event
IEV:0003362
Nuclear export of mRNA (Sprouty1)
IMR:0002081
event
IEV:0003363
Translation of Sprouty1 in cytosol
OBSOLETE: remap to 'Expression of antimicrobial peptide by DIF' IEV:0003511.
event
IEV:0003364
Expression of antimicrobial peptide by DIF [Drosophila]
true
OBSOLETE: remap to 'Expression of antimicrobial peptide by DIF' IEV:0003511.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of cecropin by DIF' IEV:0003513.
event
IEV:0003365
Expression of cecropin by DIF [Drosophila]
true
OBSOLETE: remap to 'Expression of cecropin by DIF' IEV:0003513.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of drosomycin by DIF' IEV:0003515.
event
IEV:0003366
Expression of drosomycin by DIF [Drosophila]
true
OBSOLETE: remap to 'Expression of drosomycin by DIF' IEV:0003515.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of diptericin by DIF' IEV:0003514.
event
IEV:0003367
Expression of diptericin by DIF [Drosophila]
true
OBSOLETE: remap to 'Expression of diptericin by DIF' IEV:0003514.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of antimicrobial peptide by DIF:Dorsal' IEV:0003525.
event
IEV:0003368
Expression of antimicrobial peptide by DIF:Dorsal [Drosophila]
true
OBSOLETE: remap to 'Expression of antimicrobial peptide by DIF:Dorsal' IEV:0003525.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of antimicrobial peptide by Dorsal' IEV:0003533.
event
IEV:0003369
Expression of antimicrobial peptide by Dorsal [Drosophila]
true
OBSOLETE: remap to 'Expression of antimicrobial peptide by Dorsal' IEV:0003533.
XX:<new dbxref>
OBSOLETE: remap to 'Expression of drosomycin by Dorsal' IEV:0003535.
event
IEV:0003370
Expression of drosomycin by Dorsal [Drosophila]
true
OBSOLETE: remap to 'Expression of drosomycin by Dorsal' IEV:0003535.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of drosomycin by Dorsal' IEV:0003536.
event
IEV:0003371
Transcription of drosomycin by Dorsal [Drosophila]
true
OBSOLETE: remap to 'Transcription of drosomycin by Dorsal' IEV:0003536.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of cecropin by DIF' IEV:0003516.
event
IEV:0003372
Transcription of cecropin by DIF [Drosophila]
true
OBSOLETE: remap to 'Transcription of cecropin by DIF' IEV:0003516.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of drosomycin by DIF' IEV:0003519.
event
IEV:0003373
Transcription of drosomycin by DIF [Drosophila]
true
OBSOLETE: remap to 'Transcription of drosomycin by DIF' IEV:0003519.
XX:<new dbxref>
OBSOLETE: remap to 'Transcription of diptericin by DIF' IEV:0003520.
event
IEV:0003374
Transcription of diptericin by DIF [Drosophila]
true
OBSOLETE: remap to 'Transcription of diptericin by DIF' IEV:0003520.
XX:<new dbxref>
IMR:0100319
IMR:0100320
event
IEV:0003375
Autophosphorylation of JAK1 and JAK2 in cytosol
IMR:0100319
IMR:0100322
event
IEV:0003376
Autophosphorylation of JAK1 and TYK2 in cytosol
IMR:0100320
IMR:0100322
event
IEV:0003377
Autophosphorylation of JAK2 and TYK2 in cytosol
IMR:0100319
IMR:0100321
event
IEV:0003378
Autophosphorylation of JAK1 and JAK3 in cytosol
IMR:0000226
IMR:0000827
event
IEV:0003379
Phosphorylation of ATF-2 by p38 in inner space of nucleus
IMR:0000232
IMR:0000263
event
IEV:0003380
Phosphorylation of MKK3/6 by TAK1 in cytosol
IMR:0000232
IMR:0100454
event
IEV:0003381
Phosphorylation of MKK4 by TAK1 in cytosol
The processes resulting in the physical partitioning and separation of a cell into daughter cells.
GO:0051301
event
IEV:0003382
Cell division
The processes resulting in the physical partitioning and separation of a cell into daughter cells.
GO:0051301
IMR:0000232
IMR:0000893
event
IEV:0003384
Phosphorylation of TAB2 and TAK1 in cytosol
IMR:0000232
IMR:0000441
IMR:0000893
IMR:0100427
IMR:0100488
Dissociation of IRAK from TRAF6:TAK1:TAB1:TAB2:IRAK in cytosol
event
IEV:0003385
Dissociation of TRAF6:TAK1:TAB1:TAB2 and IRAK in cytosol
IMR:0100222
event
IEV:0003386
Processing of MEKK1 in cytosol
IMR:0000414
event
IEV:0003387
Gene expression by AP-1
IMR:0000414
event
IEV:0003388
Transcription by AP-1 in nucleus
IMR:0000232
IMR:0000259
event
IEV:0003389
Phosphorylation of MKK by TAK1 in cytosol
IMR:0000259
IMR:0100222
event
IEV:0003390
Phosphorylation of MKK by MEKK1 in cytosol
The process by which a DNA strand is synthesized from template DNA by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.
EC:2.7.7.7
GO:0006271
MI:0701
PubMed:14755292
DNA strand elongation
event
IEV:0003391
Elongation
The process by which a DNA strand is synthesized from template DNA by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.
MI:0701
DNA strand elongation
MI:0701
Reaction where a phosphate is transferred between two proteins of a phosphorelay system.
EC:2.7.1.42
EC:2.7.1.61
EC:2.7.1.62
EC:2.7.1.63
EC:2.7.1.69
MI:0844
PubMed:14755292
PubMed:16712436
event
IEV:0003392
Phosphotransfer
Reaction where a phosphate is transferred between two proteins of a phosphorelay system.
MI:0844
The phenotype resulting from genetic perturbation A and the phenotype resulting from genetic perturbation B have no effect on the WT background, but the combined genetic perturbation of A and B has a phenotypic effect.
MI:0794
PubMed:15833125
synthetic
event
IEV:0003393
synthetic interaction
The phenotype resulting from genetic perturbation A and the phenotype resulting from genetic perturbation B have no effect on the WT background, but the combined genetic perturbation of A and B has a phenotypic effect.
MI:0794
The phenotype resulting from genetic perturbation of A alone, B alone and AB combined have the same effect on the WT background.
MI:0795
PubMed:15833125
asynthetic
event
IEV:0003394
asynthetic interaction
The phenotype resulting from genetic perturbation of A alone, B alone and AB combined have the same effect on the WT background.
MI:0795
The phenotype resulting from genetic perturbation of A has an effect on WT, but that effect is abolished by adding the suppressor B, which itself shows no single-mutant effect (for example, WT = B = AB < A).
MI:0796
PubMed:15833125
event
IEV:0003395
suppressive interaction
The phenotype resulting from genetic perturbation of A has an effect on WT, but that effect is abolished by adding the suppressor B, which itself shows no single-mutant effect (for example, WT = B = AB < A).
MI:0796
The phenotype resulting from genetic perturbation of A and B have different effects (in terms of direction or magnitude) on the wild-type background and the double mutant has the same phenotype as either A or B (for example, A < WT < B = AB).
MI:0797
PubMed:15833125
epistatic
event
IEV:0003396
epistatic interaction
The phenotype resulting from genetic perturbation of A and B have different effects (in terms of direction or magnitude) on the wild-type background and the double mutant has the same phenotype as either A or B (for example, A < WT < B = AB).
MI:0797
The phenotype resulting from genetic perturbation of A has an effect only in the B background, or the B mutant has an effect only in the A background.
MI:0798
PubMed:15833125
conditional
event
IEV:0003397
conditional interaction
The phenotype resulting from genetic perturbation of A has an effect only in the B background, or the B mutant has an effect only in the A background.
MI:0798
The A genetic perturbation enhances the phenotype of the B perturbation, or vice versa (e.g. WT = A < B < AB or WT = B < A < AB). This could be conditional or additive by the above scheme.
MI:0802
PubMed:15833125
enhancement
event
IEV:0003398
enhancement interaction
The A genetic perturbation enhances the phenotype of the B perturbation, or vice versa (e.g. WT = A < B < AB or WT = B < A < AB). This could be conditional or additive by the above scheme.
MI:0802
Single-mutant phenotype effects combine to give a double-mutant effect different from the wild type and different from single mutant effect. For instance WT < A= B < AB, B < WT = AB < A, WT < A < B < AB, B < WT < AB < A, and all additional inequalities obtained by interchanging A and B, or reversing the effect of both A and B.
MI:0799
PubMed:15833125
additive
event
IEV:0003399
additive interaction
Single-mutant phenotype effects combine to give a double-mutant effect different from the wild type and different from single mutant effect. For instance WT < A= B < AB, B < WT = AB < A, WT < A < B < AB, B < WT < AB < A, and all additional inequalities obtained by interchanging A and B, or reversing the effect of both A and B.
MI:0799
The phenotype resulting from genetic perturbation of B shows opposing effects in the WT and A backgrounds (for example, B > WT and AB< A); or, A shows opposing effects in the WT and B backgrounds, but not both.
MI:0800
PubMed:15833125
single nonmonotonic
event
IEV:0003400
single nonmonotonic interaction
The phenotype resulting from genetic perturbation of B shows opposing effects in the WT and A backgrounds (for example, B > WT and AB< A); or, A shows opposing effects in the WT and B backgrounds, but not both.
MI:0800
The phenotype resulting from genetic perturbation of both A and B show opposing effects in the WT background and the background with the other mutant gene.
MI:0801
PubMed:15833125
double nonmonotonic
event
IEV:0003401
double nonmonotonic interaction
The phenotype resulting from genetic perturbation of both A and B show opposing effects in the WT background and the background with the other mutant gene.
MI:0801
IMR:0002642
IMR:0010252
event
IEV:0003402
Binding of Fas and DAXX in cytosol
IMR:0000225
IMR:0000369
event
IEV:0003403
Phosphorylation of transcriptional regulator by JNK_p in inner space of nucleus
IMR:0000225
IMR:0001945
event
IEV:0003404
Phosphorylation of Itch by JNK_p in inner space of nucleus
FGF8 signaling pathway
FGF8 signaling pathway(Mouse)
FGF8 signaling pathway(Xenopus)
event
IEV:0003405
FGFR1 signaling pathway
IMR:0002642
IMR:0100218
event
IEV:0003406
Activation of ASK1 by DAXX in cytosol
IMR:0000225
IMR:0000456
event
IEV:0003407
Phosphorylation of 14-3-3 by JNK_p in cytosol
IMR:0000453
IMR:0000456
event
IEV:0003408
Dissociation of 14-3-3_p and Bax in cytosol
event
IEV:0003409
Cleavage in extracellular
OBSOLETE: remap to 'Cleavage of Spaetzle by serine protease' IEV:0003502.
event
IEV:0003410
Cleavage of Spaetzle by serine protease [Drosophila]
true
OBSOLETE: remap to 'Cleavage of Spaetzle by serine protease' IEV:0003502.
XX:<new dbxref>
OBSOLETE: remap to 'Cleavage of Spaetzle by PSH' IEV:0003505.
event
IEV:0003411
Cleavage of Spaetzle by PSH [Drosophila]
true
OBSOLETE: remap to 'Cleavage of Spaetzle by PSH' IEV:0003505.
XX:<new dbxref>
event
IEV:0003412
Caspase3 activation signaling (not through mitochondria)
event
IEV:0003413
Caspase3 activation signaling (through mitochondria)
IMR:0100296
event
IEV:0003414
Caspase3 homodimer formation in cytosol
IMR:0100296
IMR:0100300
event
IEV:0003415
Hydrolysis of Procaspase3 by caspase8 in cytosol
IMR:0001945
IMR:0002641
event
IEV:0003416
Ubiquitination of c-FLIP by Itch_p in cytosol
IMR:0000269
IMR:0100423
IMR:0100464
event
IEV:0003417
Dimerization of TRADD:TRAF2:RIP complex in cytosol
IMR:0002641
event
IEV:0003418
Proteasome degradation of c-FLIP in cytosol
IMR:0000243
IMR:0000269
event
IEV:0003419
Phosphorylation of IKK complex by RIP in cytosol
IMR:0000382
IMR:0002641
event
IEV:0003420
Gene expression of c-FLIP by NF-kappaB
IMR:0002641
event
IEV:0003421
Transcription of c-FLIP gene in nucleus
IMR:0002641
event
IEV:0003422
Nuclear export of mRNA (c-FLIP)
IMR:0002641
event
IEV:0003423
Translation of c-FLIP in cytosol
IMR:0001148
IMR:0100027
event
IEV:0003424
Binding of DAG and PKC delta and active conformational change of PKC delta in cytosol
IMR:0000231
IMR:0001148
event
IEV:0003425
Phosphorylation of Raf by PKC delta in cytosol
IMR:0000246
IMR:0100027
event
IEV:0003426
Binding of DAG and nPKC and active conformational change of nPKC in cytosol
IMR:0000245
IMR:0100355
event
IEV:0003427
Phosphorylation of Raf1 by PKC in cytosol
IMR:0001968
IMR:0100024
event
IEV:0003428
Binding of Epac1 and cAMP in cytosol
IMR:0001504
IMR:0001968
event
IEV:0003429
Binding of Epac1 and Rap1 in cytosol
IMR:0002671
IMR:0100126
event
IEV:0003430
Binding of Adenosine and Adenosine A2A receptor in extracellular
IMR:0002671
IMR:0100366
event
IEV:0003431
Binding of Adenosine A2A receptor and G alpha s in cytosol
IMR:0001354
IMR:0002671
IMR:0100018
IMR:0100366
event
IEV:0003432
Dissociation of Adenosine A2A receptor, G alpha s-GTP and G beta:G gamma in cytosol
IMR:0000375
IMR:0100320
event
IEV:0003433
Phosphorylation of STAT1 by JAK2_p in cytosol
IMR:0000016
IMR:0000127
event
IEV:0003434
Binding of EPO and EPO receptor complex and conformational change of receptors in plasma membrane
IMR:0000127
IMR:0100320
event
IEV:0003435
Phosphorylation of EPO receptor by JAK2 in cytosol
IMR:0000127
IMR:0100733
event
IEV:0003436
Binding of EPO receptor and STAT5 in cytosol
IMR:0000127
IMR:0100733
event
IEV:0003437
Dissociation of EPO receptor and STAT5 in cytosol
IMR:0000127
IMR:0000377
event
IEV:0003438
Binding of EPO receptor and STAT3 in cytosol
IMR:0000127
IMR:0000377
event
IEV:0003439
Dissociation of EPO receptor and STAT3 in cytosol
IMR:0000127
IMR:0000265
event
IEV:0003440
Binding of EPO receptor and PI3K in cytosol
IMR:0000265
IMR:0100320
event
IEV:0003441
Phosphorylation of PI3K by JAK2_p in cytosol
IMR:0002655
IMR:0100484
event
IEV:0003442
Phosphorylation of CARMA1 by PKC theta in cytosol
IMR:0002655
IMR:0002658
event
IEV:0003443
Binding of CARMA1 and BCL10 in cytosol
event
IEV:0003444
IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)
IMR:0001146
IMR:0002655
event
IEV:0003445
Phosphorylation of CARMA1 by PKC beta in cytosol
The cleavage of a methyl group from a polypeptide. Methylation is generally an irreversible reaction except in mamalian.
GO:0006482
MI:0871
event
IEV:0003446
Demethylation
The cleavage of a methyl group from a polypeptide. Methylation is generally an irreversible reaction except in mamalian.
MI:0871
Catalysis of the hydrolisis of a nucleoside triphosphate into a nucleoside diphosphate plus phosphate.
GO:0017111
MI:0881
event
IEV:0003447
nucleoside triphosphatase reaction
Catalysis of the hydrolisis of a nucleoside triphosphate into a nucleoside diphosphate plus phosphate.
MI:0881
Catalysis of the hydrolisis of ATP+ H2O = ADP + phosphate.
GO:0016887
MI:0882
event
IEV:0003448
atpase reaction
Catalysis of the hydrolisis of ATP+ H2O = ADP + phosphate.
MI:0882
Catalysis of the hydrolisis of GTP+ H2O = GDP + phosphate.
GO:0003924
MI:0883
event
IEV:0003449
gtpase reaction
Catalysis of the hydrolisis of GTP+ H2O = GDP + phosphate.
MI:0883
IMR:0000340
IMR:0000351
REACT:646.3
event
IEV:0003450
Binding of IRS_p and Grb2 in cytosol
IMR:0010283
event
IEV:0003451
Translocation of GLUT4 from cytosol to plasma membrane
IMR:0100735
IMR:0100838
event
IEV:0003452
Binding of GHR_p and SOCS-2 in cytosol
IMR:0100320
IMR:0100837
event
IEV:0003453
Binding of JAK2_p and SOCS-1 in cytosol
IMR:0100735
IMR:0100839
event
IEV:0003454
Binding of GHR_p and SOCS-3 in cytosol
PubMed:12210516
C. elegans endoderm induction Wnt signaling pathway
event
IEV:0003455
Endoderm induction Wnt signaling pathway
Drosophila IMD pathway [Drosophila]
event
IEV:0003456
IMD signaling pathway
IMR:0001655
IMR:0001787
Binding of PGRP-LC and LPS [Drosophila]
event
IEV:0003457
Binding of PGRP-LC and LPS in extracellular
IMR:0100300
IMR:0100463
Binding of dFADD and Dredd [Drosophila]
event
IEV:0003458
Binding of FADD and caspase8 in cytosol
IMR:0000232
IMR:0001808
Activation of TAK1 by IMD [Drosophila]
event
IEV:0003459
Activation of TAK1 by IMD in cytosol
IGS:0000010
IMR:0001806
IMR:0001814
Binding of DIF:Relish and NF-kappaB binding sequence [Drosophila]
event
IEV:0003460
Binding of DIF:Relish and NF-kappaB binding sequence in inner space of nucleus
IMR:0001787
IMR:0001808
Binding of PGRP-LC and IMD [Drosophila]
event
IEV:0003461
Binding of PGRP-LC and IMD in cytosol
IMR:0001816
IMR:0100300
Binding of Dnr-1 and Dredd [Drosophila]
event
IEV:0003462
Binding of Dnr-1 and caspase8 in cytosol
IMR:0001808
IMR:0100463
Binding of IMD and dFADD [Drosophila]
event
IEV:0003463
Binding of IMD and FADD in cytosol
IMR:0001814
IMR:0001815
Expression of antimicrobial peptide by Relish [Drosophila]
event
IEV:0003464
Expression of antimicrobial peptide by Relish
IMR:0001699
IMR:0001787
Binding of PGRP-LC and PGN [Drosophila]
event
IEV:0003465
Binding of PGRP-LC and PGN in extracellular
IMR:0001699
IMR:0001788
Binding of PGRP-LE and PGN [Drosophila]
event
IEV:0003466
Binding of PGRP-LE and PGN in extracellular
IMR:0001814
IMR:0100300
Cleavage and activation of Relish by Dredd [Drosophila]
event
IEV:0003467
Cleavage and activation of Relish by caspase8 in cytosol
IGS:0000010
IMR:0001814
Binding of Relish and NF-kappaB binding sequence [Drosophila]
event
IEV:0003468
Binding of Relish and NF-kappaB binding sequence in inner space of nucleus
IMR:0000243
IMR:0001814
Phosphorylation of Relish by IKK [Drosophila]
event
IEV:0003469
Phosphorylation of Relish by IKK in cytosol
IMR:0001814
Nuclear import of Relish [Drosophila]
event
IEV:0003471
Nuclear import of Relish
IMR:0001814
IMR:0001817
Expression of diptericin by Relish [Drosophila]
event
IEV:0003472
Expression of diptericin by Relish
IMR:0001814
IMR:0001827
Expression of drosocin by Relish [Drosophila]
event
IEV:0003473
Expression of drosocin by Relish
IMR:0001814
IMR:0001823
Expression of attacin by Relish [Drosophila]
event
IEV:0003474
Expression of attacin by Relish
IMR:0001814
IMR:0001818
Expression of drosomycin by Relish [Drosophila]
event
IEV:0003475
Expression of drosomycin by Relish
IMR:0001814
IMR:0001823
Transcription of attacin by Relish [Drosophila]
event
IEV:0003476
Transcription of attacin by Relish in nucleus
IMR:0001806
IMR:0001814
IMR:0001828
Expression of defensin by DIF:Relish [Drosophila]
event
IEV:0003477
Expression of defensin by DIF:Relish
IMR:0001814
IMR:0001815
Transcription of antimicrobial peptide by Relish [Drosophila]
event
IEV:0003478
Transcription of antimicrobial peptide by Relish in nucleus
IMR:0001814
IMR:0001818
Transcription of drosomycin by Relish [Drosophila]
event
IEV:0003479
Transcription of drosomycin by Relish in nucleus
IMR:0001814
IMR:0001819
Transcription of cecropin by Relish [Drosophila]
event
IEV:0003480
Transcription of cecropin by Relish in nucleus
IMR:0001806
IMR:0001814
IMR:0001828
Transcription of defensin by DIF:Relish [Drosophila]
event
IEV:0003481
Transcription of defensin by DIF:Relish in nucleus
IMR:0001814
IMR:0001827
Transcription of drosocin by Relish [Drosophila]
event
IEV:0003482
Transcription of drosocin by Relish in nucleus
IMR:0001814
IMR:0001817
Transcription of diptericin by Relish [Drosophila]
event
IEV:0003483
Transcription of diptericin by Relish in nucleus
IMR:0001818
Translation of drosomycin [Drosophila]
event
IEV:0003484
Translation of drosomycin in cytosol
IMR:0001823
Translation of attacin [Drosophila]
event
IEV:0003485
Translation of attacin in cytosol
IMR:0001819
Translation of cecropin [Drosophila]
event
IEV:0003486
Translation of cecropin in cytosol
IMR:0001828
Translation of Defensin [Drosophila]
event
IEV:0003487
Translation of defensin in cytosol
IMR:0001827
Translation of drosocin [Drosophila]
event
IEV:0003488
Translation of drosocin in cytosol
IMR:0001817
Translation of diptericin [Drosophila]
event
IEV:0003489
Translation of diptericin in cytosol
The series of molecular signals initiated by binding of a ligand to an extracellular ligand to the Toll receptor on the surface of the target cell.
GO:0008063
Tl signaling pathway
Toll receptor signaling pathway
Drosophila Toll-like receptor signaling
event
IEV:0003490
Toll receptor signaling
The series of molecular signals initiated by binding of a ligand to an extracellular ligand to the Toll receptor on the surface of the target cell.
GO:0008063
IMR:0000304
Activation of serine protease [Drosophila]
event
IEV:0003491
Activation of serine protease in extracellular
IMR:0001795
IMR:0001796
Activation of PSH by GNBP3 [Drosophila]
event
IEV:0003492
Activation of PSH by GNBP3 in extracellular
IMR:0001802
Autophosphorylation of Pelle [Drosophila]
event
IEV:0003493
Autophosphorylation of Pelle in cytosol
IMR:0001789
IMR:0001795
Binding of GNBP3 and beta1-3 glucan [Drosophila]
event
IEV:0003494
Binding of GNBP3 and beta1-3 glucan in extracellular
IMR:0000247
IMR:0001803
IMR:0100423
Binding of TRAF2 and Ref(2):DaPKC in cytosol
Binding of dTRAF2 and Ref(2):DaPKC [Drosophila]
event
IEV:0003495
Binding of TRAF2 and Ref2P:aPKC in cytosol
IMR:0001785
IMR:0001793
Binding of PGRP-SA and GNBP1 [Drosophila]
event
IEV:0003496
Binding of PGRP-SA and GNBP1 in extracellular
IMR:0001699
IMR:0001785
IMR:0001793
Binding of PGRP-SA:GNBP1 and PGN [Drosophila]
event
IEV:0003497
Binding of PGRP-SA:GNBP1 and PGN in extracellular
IMR:0001699
IMR:0001786
Binding of PGRP-SD and PGN [Drosophila]
event
IEV:0003498
Binding of PGRP-SD and PGN in extracellular
IMR:0001467
IMR:0001799
IMR:0100465
Binding of Toll and dMyD88:Tube [Drosophila]
event
IEV:0003499
Binding of Toll and MyD88:Tube in cytosol
IMR:0001467
IMR:0001798
Binding of Toll and Spaetzle [Drosophila]
event
IEV:0003500
Binding of Toll and Spaetzle in extracellular
IMR:0001467
IMR:0001799
IMR:0001802
IMR:0100465
Binding of Toll:dMyD88:Tube and Pelle [Drosophila]
event
IEV:0003501
Binding of Toll:MyD88:Tube and Pelle in cytosol
IMR:0000304
IMR:0001798
Cleavage of Spaetzle by serine protease [Drosophila]
event
IEV:0003502
Cleavage of Spaetzle by serine protease in extracellular
IMR:0001796
IMR:0001798
Activation of Spaetzle by PSH [Drosophila]
event
IEV:0003503
Activation of Spaetzle by PSH in extracellular
IMR:0000304
IMR:0001798
Activation of Spaetzle by serine protease [Drosophila]
event
IEV:0003504
Activation of Spaetzle by serine protease in extracellular
IMR:0001796
IMR:0001798
Cleavage of Spaetzle by PSH [Drosophila]
event
IEV:0003505
Cleavage of Spaetzle by PSH in extracellular
DIF signaling [Drosophila]
event
IEV:0003506
DIF signaling
Dorsal signaling [Drosophila]
event
IEV:0003507
Dorsal signaling
DIF:Dorsal signaling [Drosophila]
event
IEV:0003508
DIF:Dorsal signaling
IMR:0001806
Activation of DIF [Drosophila]
event
IEV:0003509
Activation of DIF in cytosol
IMR:0001805
IMR:0001806
Dissociation of Cactus_p and DIF [Drosophila]
event
IEV:0003510
Dissociation of Cactus_p and DIF in cytosol
IMR:0001806
IMR:0001815
Expression of antimicrobial peptide by DIF [Drosophila]
event
IEV:0003511
Expression of antimicrobial peptide by DIF
IGS:0000010
IMR:0001806
Binding of DIF and NF-kappaB binding sequence [Drosophila]
event
IEV:0003512
Binding of DIF and NF-kappaB binding sequence in inner space of nucleus
IMR:0001806
IMR:0001819
Expression of cecropin by DIF [Drosophila]
event
IEV:0003513
Expression of cecropin by DIF
IMR:0001806
IMR:0001817
Expression of diptericin by DIF [Drosophila]
event
IEV:0003514
Expression of diptericin by DIF
IMR:0001806
IMR:0001818
Expression of drosomycin by DIF [Drosophila]
event
IEV:0003515
Expression of drosomycin by DIF
IMR:0001806
IMR:0001819
Transcription of cecropin by DIF [Drosophila]
event
IEV:0003516
Transcription of cecropin by DIF in nucleus
IMR:0001806
IMR:0001815
Transcription of antimicrobial peptide by DIF [Drosophila]
event
IEV:0003517
Transcription of antimicrobial peptide by DIF in nucleus
IMR:0001815
Transcription of antimicrobial peptide [Drosophila]
event
IEV:0003518
Transcription of antimicrobial peptide in nucleus
IMR:0001806
IMR:0001818
Transcription of drosomycin by DIF [Drosophila]
event
IEV:0003519
Transcription of drosomycin by DIF in nucleus
IMR:0001806
IMR:0001817
Transcription of diptericin by DIF [Drosophila]
event
IEV:0003520
Transcription of diptericin by DIF in nucleus
IMR:0001806
Nuclear import of DIF [Drosophila]
event
IEV:0003521
Nuclear import of DIF
IMR:0001805
Phosphorylation of Cactus [Drosophila]
event
IEV:0003522
Phosphorylation of Cactus in cytosol
IMR:0001806
IMR:0001807
Activation of DIF:Dorsal [Drosophila]
event
IEV:0003523
Activation of DIF:Dorsal in cytosol
IMR:0001805
IMR:0001806
IMR:0001807
Dissociation of Cactus_p and Dorsal:DIF [Drosophila]
event
IEV:0003524
Dissociation of Cactus_p and Dorsal:DIF in cytosol
IMR:0001806
IMR:0001807
IMR:0001815
Expression of antimicrobial peptide by DIF:Dorsal [Drosophila]
event
IEV:0003525
Expression of antimicrobial peptide by DIF:Dorsal
IGS:0000010
IMR:0001806
IMR:0001807
Binding of DIF:Dorsal and NF-kappaB binding sequence [Drosophila]
event
IEV:0003526
Binding of DIF:Dorsal and NF-kappaB binding sequence in inner space of nucleus
IMR:0001806
IMR:0001807
IMR:0001815
Transcription of antimicrobial peptide by DIF:Dorsal [Drosophila]
event
IEV:0003527
Transcription of antimicrobial peptide by DIF:Dorsal in nucleus
IMR:0001806
IMR:0001807
Nuclear import of Dorsal:DIF [Drosophila]
event
IEV:0003528
Nuclear import of Dorsal:DIF
IMR:0001467
IMR:0001798
Dimerization of Toll by Spaetzle [Drosophila]
event
IEV:0003529
Dimerization of Toll by Spaetzle in plasma membrane
IMR:0001467
IMR:0001799
IMR:0001802
IMR:0100465
Dissociation of Toll:dMyD88:Tube and Pelle [Drosophila]
event
IEV:0003530
Dissociation of Toll:MyD88:Tube and Pelle in cytosol
IMR:0001807
Activation of Dorsal [Drosophila]
event
IEV:0003531
Activation of Dorsal in cytosol
IMR:0001805
IMR:0001807
Dissociation of Cactus_p and Dorsal [Drosophila]
event
IEV:0003532
Dissociation of Cactus_p and Dorsal in cytosol
IMR:0001807
IMR:0001815
Expression of antimicrobial peptide by Dorsal [Drosophila]
event
IEV:0003533
Expression of antimicrobial peptide by Dorsal
IGS:0000010
IMR:0001807
Binding of Dorsal and NF-kappaB binding sequence [Drosophila]
event
IEV:0003534
Binding of Dorsal and NF-kappaB binding sequence in inner space of nucleus
IMR:0001807
IMR:0001818
Expression of drosomycin by Dorsal [Drosophila]
event
IEV:0003535
Expression of drosomycin by Dorsal
IMR:0001807
IMR:0001818
Transcription of drosomycin by Dorsal [Drosophila]
event
IEV:0003536
Transcription of drosomycin by Dorsal in nucleus
IMR:0001807
IMR:0001815
Transcription of antimicrobial peptide by Dorsal [Drosophila]
event
IEV:0003537
Transcription of antimicrobial peptide by Dorsal in nucleus
IMR:0001807
Nuclear import of Dorsal [Drosophila]
event
IEV:0003538
Nuclear import of Dorsal
IMR:0000247
IMR:0001803
IMR:0100423
Nuclear import of TRAF2:Ref(2)P:DaPKC
Nuclear import of dTRAF2:Ref(2)P:DaPKC [Drosophila]
event
IEV:0003539
Nuclear import of TRAF2:Ref2P:aPKC
IMR:0001802
IMR:0100423
Phosphorylation of dTRAF2 by Pelle_p [Drosophila]
event
IEV:0003540
Phosphorylation of TRAF2 by Pelle_p in cytosol
IMR:0001935
Activation of Deltex [Drosophila]
Activation of Deltex [Mammalian]
event
IEV:0003541
Activation of Deltex in cytosol
IMR:0001955
Activation of Numb [Mammalian]
event
IEV:0003542
Activation of Numb in cytosol
Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
event
IEV:0003543
Regulation of Ras-Raf-MAPK signaling by spred
Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
event
IEV:0003544
Negative regulation of Ras-Raf-MAPK signaling by spred
Positive regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
event
IEV:0003545
Positive regulation of Ras-Raf-MAPK signaling by spred
Negative feedback regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
event
IEV:0003546
Negative feedback regulation of Ras-Raf-MAPK signaling by spred
IMR:0002072
Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty (Drosophila)
event
IEV:0003547
Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty
event
IEV:0003548
Inactivation in plasma membrane
event
IEV:0003549
Transcription in nucleus
event
IEV:0003550
Translation in cytosol
IMR:0100144
IMR:0100677
event
IEV:0003551
Binding of IGF-1 and IGF-1 receptor in extracellular
IMR:0100677
event
IEV:0003552
Autophosphorylation of IGF-1 receptor in plasma membrane
IMR:0000347
IMR:0100677
event
IEV:0003553
Binding of IGF-1 receptor_p and Shc in cytosol
IMR:0000347
IMR:0100677
event
IEV:0003554
Phosphorylation of Shc by IGF receptor_p in cytosol
IMR:0100393
IMR:0100677
event
IEV:0003555
Binding of IGF-1 receptor_p and IRS-1 in cytosol
IMR:0100393
IMR:0100677
event
IEV:0003556
Phosphorylation of IRS-1 by IGF-1 receptor in cytosol
IMR:0000265
IMR:0100393
event
IEV:0003557
Binding of IRS-1_p and PI3K in cytosol
IMR:0000340
IMR:0100393
event
IEV:0003558
Binding of IRS-1_p and Grb2 in cytosol
event
IEV:0003559
IGF1 signaling pathway
event
IEV:0003560
Negative regulation of IGF1 signaling pathway
IMR:0002688
IMR:0100144
event
IEV:0003561
Binding of IGF-1 and IGFBP in extracellular
event
IEV:0003562
Regulation of IGF1 signaling pathway
event
IEV:0003563
Positive regulation of IGF1 signaling pathway
IMR:0002691
IMR:0100144
event
IEV:0003564
Binding of IGF-1 and IGFBP-3 in extracellular
IMR:0002691
IMR:0002713
event
IEV:0003565
Cleavage of IGFBP-3 by PSA in extracellular
IMR:0002693
IMR:0100144
event
IEV:0003566
Binding of IGF-1 and IGFBP-5 in extracellular
IMR:0000088
event
IEV:0003567
Complex formation of Estrogen receptor in cytosol
CHEBI:50114
IMR:0000088
event
IEV:0003568
Binding of Estrogen and Estrogen receptor in cytosol
Any process that modulates the frequency, rate or extent of the Tl signaling pathway.
GO:0008592
Regulation of Toll receptor signaling pathway
regulation of Tl signaling pathway
event
IEV:0003569
Regulation of Toll receptor signaling
Any process that modulates the frequency, rate or extent of the Tl signaling pathway.
GO:0008592
IMR:0000702
IMR:0001424
event
IEV:0003570
Binding of BMP2 and BMP receptor II in extracellular
IMR:0000040
IMR:0000702
event
IEV:0003571
Binding of BMP and BMP receptor II in extracellular
IMR:0000702
IMR:0001424
IMR:0001425
event
IEV:0003572
Binding of BMP2:BMP receptor II and BMP receptor I in extracellular
IMR:0000040
IMR:0000702
IMR:0001425
event
IEV:0003573
Binding of BMP and BMP receptor I/II in extracellular
IMR:0000040
IMR:0000702
IMR:0001425
event
IEV:0003574
Binding of BMP:BMP receptor II and BMP receptor I in plasma membrane
IMR:0100313
IMR:0100315
event
IEV:0003575
Complex formation of Smad5 and Smad4 in cytosol
IMR:0100314
IMR:0100315
event
IEV:0003576
Complex formation of Smad8 and Smad4 in cytosol
IMR:0100311
IMR:0100315
event
IEV:0003577
Complex formation of Smad2 and Smad4 in cytosol
IMR:0100312
IMR:0100315
event
IEV:0003578
Complex formation of Smad3 and Smad4 in cytosol
IMR:0000702
IMR:0001425
IMR:0100310
event
IEV:0003579
Binding of BMP receptor complex and Smad1 in cytosol
IMR:0000702
IMR:0001425
IMR:0100310
event
IEV:0003580
Dissociation of BMP receptor complex and Smad1 in cytosol
IMR:0000371
IMR:0000702
IMR:0001425
event
IEV:0003581
Binding of BMP receptor complex and R-Smad in cytosol
IMR:0000371
IMR:0000702
IMR:0001425
event
IEV:0003582
Dissociation of BMP receptor complex and R-Smad in cytosol
IMR:0000093
IMR:0000094
event
IEV:0003583
Phosphorylation of TGF beta superfamily receptor I by TGF beta superfamily receptor II in cytosol
IMR:0000093
IMR:0000371
event
IEV:0003584
Phosphorylation of R-Smad by TGF beta superfamily receptor I in cytosol
IMR:0000371
IMR:0001425
event
IEV:0003585
Phosphorylation of R-Smad by BMP receptor I in cytosol
IMR:0000371
IMR:0000372
event
IEV:0003586
Complex formation of R-Smad and Co-Smad in cytosol
IMR:0000040
event
IEV:0003587
Cleavage of BMP in extracellular
IMR:0000371
event
IEV:0003588
Dephosphorylation of R-Smad in inner space of nucleus
IMR:0000371
IMR:0100315
event
IEV:0003589
Dissociation of R-Smad and Smad4 in inner space of nucleus
IMR:0000371
event
IEV:0003590
Nuclear export of R-Smad
IMR:0000092
IMR:0000371
event
IEV:0003591
Dissociation of TGF beta superfamily receptor complex and R-Smad in cytosol
IMR:0000092
IMR:0000371
event
IEV:0003592
Binding of TGF beta superfamily receptor complex and R-Smad in cytosol
The aggregation and bonding together of a type II transforming growth factor beta (TGFbeta) receptor dimer with a type I TGFbeta receptor dimer, following ligand binding, to form a heterotetrameric TGFbeta receptor complex.
IEV:0001256
GO:0007181
IMR:0000036
IMR:0000093
IMR:0000094
Complex formation of TGF beta superfamily receptor in plasma membrane
TGF beta superfamily receptor complex formation
event
IEV:0003593
Binding of TGF beta super family:Type II receptor and Type I receptor in plasma membrane
The aggregation and bonding together of a type II transforming growth factor beta (TGFbeta) receptor dimer with a type I TGFbeta receptor dimer, following ligand binding, to form a heterotetrameric TGFbeta receptor complex.
XX:<new dbxref>
IMR:0000036
IMR:0000094
event
IEV:0003594
Binding of TGF beta superfamily and TGF beta superfamily receptor II in extracellular
event
IEV:0003595
IL23 signaling pathway (JAK2, TYK2, STAT3, STAT4)
IMR:0002716
IMR:0002717
event
IEV:0003596
Binding of IL-23 and IL-23 receptor and conformational change of receptors in plasma membrane
IMR:0002717
IMR:0100320
IMR:0100322
event
IEV:0003597
Phosphorylation of IL-23 receptor by JAK2 and TYK2 in cytosol
IMR:0000378
IMR:0002717
event
IEV:0003598
Binding of IL-23 receptor and STAT4 in cytosol
IMR:0000377
IMR:0002717
event
IEV:0003599
Binding of IL-23 receptor and STAT3 in cytosol
IMR:0000377
IMR:0100320
IMR:0100322
event
IEV:0003600
Phosphorylation of STAT3 by JAK2_p and TYK2_p in cytosol
IMR:0000377
IMR:0002717
event
IEV:0003601
Dissociation of IL-23 receptor and STAT3 in cytosol
IMR:0000378
IMR:0002717
event
IEV:0003602
Dissociation of IL-23 receptor and STAT4 in cytosol
IMR:0000377
IMR:0000378
event
IEV:0003603
Dimerization of STAT3 and STAT4 in cytosol
IMR:0000377
IMR:0000378
event
IEV:0003604
Nuclear import of STAT3:STAT4 heterodimer
IGS:0000028
IMR:0000377
IMR:0000378
event
IEV:0003605
Binding of STAT3:STAT4 heterodimer and responsive element in inner space of nucleus
Any process by which an RNA molecule is cleaved at specific sites or in a regulated manner.
GO:0006396
MI:0902
event
IEV:0003606
RNA cleavage
Any process by which an RNA molecule is cleaved at specific sites or in a regulated manner.
MI:0902
Covalent bond breakage of a nucleic acid molecule leading to the formation of smaller fragments.
MI:0910
event
IEV:0003607
nucleic acid cleavage
Covalent bond breakage of a nucleic acid molecule leading to the formation of smaller fragments.
MI:0910
IMR:0000381
IMR:0100319
IMR:0100322
event
IEV:0003608
Phosphorylation of STAT6 by JAK1_p and TYK2_p in cytosol
event
IEV:0003609
IL13 signaling pathway (JAK1, TYK2, STAT6)
IMR:0000115
IMR:0000595
event
IEV:0003610
Binding of IL-13 and IL-13 receptor and conformational change of receptors in plasma membrane
IMR:0000107
IMR:0100319
IMR:0100322
event
IEV:0003611
Phosphorylation of IL-4 receptor by JAK1 and TYK2 in cytosol
event
IEV:0003612
Regulation of IL13 signaling pathway (JAK1, TYK2, STAT6)
event
IEV:0003613
Negative regulation of IL13 signaling pathway (JAK1, TYK2, STAT6)
IMR:0000115
IMR:0000595
event
IEV:0003614
Binding of IL-13 and IL-13 receptor in extracellular
IMR:0000101
IMR:0000347
event
IEV:0003615
Binding of IL-5 receptor and Shc in cytosol
IMR:0000347
IMR:0100320
event
IEV:0003616
Phosphorylation of Shc by JAK2_p in cytosol
IMR:0000107
IMR:0000351
event
IEV:0003617
Binding of IRS and IL-4 receptor in cytosol
IMR:0000107
IMR:0100393
event
IEV:0003618
Binding of IRS-1 and IL-4 receptor in cytosol
IMR:0000107
IMR:0100394
event
IEV:0003619
Binding of IRS-2 and IL-4 receptor in cytosol
event
IEV:0003620
IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)
IMR:0000009
IMR:0000101
event
IEV:0003621
Binding of IL5 and IL5 receptor and conformational change of receptors in plasma membrane
IMR:0000101
IMR:0100320
event
IEV:0003622
Phosphorylation of IL-5 receptor and JAK2 in cytosol
IMR:0000101
IMR:0100733
event
IEV:0003623
Binding of IL-5 receptor and STAT5 in cytosol
IMR:0000101
IMR:0000375
event
IEV:0003624
Binding of IL-5 receptor and STAT1 in cytosol
IMR:0000101
IMR:0100733
event
IEV:0003625
Dissociation of IL-5 receptor and STAT5 in cytosol
IMR:0000101
IMR:0000375
event
IEV:0003626
Dissociation of IL-5 receptor and STAT1 in cytosol
IMR:0000078
IMR:0000265
event
IEV:0003627
Binding of insulin receptor and PI3K in cytosol
IEV:0003649
IMR:0002804
Gene expression by Forkhead box domain transcription factor
event
IEV:0003628
Gene expression by FOXO
IMR:0000078
IMR:0000340
event
IEV:0003629
Binding of insulin receptor and Grb2 in cytosol
IMR:0000231
IMR:0000280
event
IEV:0003630
Dephosphorylation of Raf by PP2A in cytosol
IMR:0000231
IMR:0000290
IMR:0001354
event
IEV:0003631
Binding of Ras-GTP and Raf in cytosol
IMR:0000231
IMR:0000290
IMR:0001354
event
IEV:0003632
Dissociation of Ras-GTP and Raf in cytosol
IMR:0000250
IMR:0002759
event
IEV:0003633
Phosphorylation of TSC2 by AKT in cytosol
IMR:0001354
IMR:0002752
IMR:0002759
event
IEV:0003634
Hydrolysis of GTP by Rheb and TSC2 in cytosol
IMR:0001354
IMR:0001357
IMR:0002752
event
IEV:0003635
GDP-GTP exchange of Rheb in cytosol
IMR:0002721
IMR:0002730
IMR:0002736
Activation of TOR:LST8:Raptor in cytosol
event
IEV:0003636
Activation of TORC1 in cytosol
IMR:0000909
event
IEV:0003637
Binding of eIF4F and mRNA in cytosol
IMR:0001845
IMR:0002721
IMR:0002730
IMR:0002736
Phosphorylation of p70S6K by TOR of TOR:LST8:Raptor in cytosol
event
IEV:0003638
Phosphorylation of p70S6K by TOR of TORC1 in cytosol
IMR:0002721
IMR:0002730
IMR:0002736
IMR:0011156
Phosphorylation of 4EBP-1 by TOR of TOR:LST8:Raptor in cytosol
event
IEV:0003639
Phosphorylation of 4EBP-1 by TOR of TORC1 in cytosol
IMR:0002798
IMR:0100711
event
IEV:0003640
Phosphorylation of S6RP by S6K1 in cytosol
IMR:0001845
IMR:0100711
event
IEV:0003641
Phosphorylation of S6RP by p70S6K in cytosol
IMR:0011155
IMR:0011156
event
IEV:0003642
Dissociation of 4EBP-1 and eIF4E in cytosol
IMR:0000909
event
IEV:0003643
Complex formation of eIF4F in cytosol
IMR:0011155
IMR:0011156
event
IEV:0003644
Binding of 4EBP-1 and eIF4E in cytosol
IMR:0002721
IMR:0002818
IMR:0100489
event
IEV:0003645
Binding of rapamycin:FKBP12 and TOR in cytosol
IMR:0002770
IMR:0100737
event
IEV:0003646
Phosphorylation of Glycogen synthase by GSK3b in cytosol
IMR:0002759
IMR:0002775
event
IEV:0003647
Phosphorylation of TSC2 by AMPK in cytosol
IMR:0002759
IMR:0100737
event
IEV:0003648
Phosphorylation of TSC2 by GSK3b in cytosol
true
true
true
IMR:0000250
event
IEV:0003652
Nuclear import of AKT
true
true
IMR:0000250
event
IEV:0003655
Negative regulation of transcription by AKT
IMR:0000250
IMR:0002721
IMR:0002736
IMR:0002742
IMR:0002747
Phosphorylation of AKT by TOR of TOR:LST8:SIN1:Rictor in cytosol
event
IEV:0003656
Phosphorylation of AKT by TOR of TORC2 in cytosol
true
A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
GO:0003013
event
IEV:0003658
Circulatory system process
A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
GO:0003013
IEV:0003653
IMR:0000250
IMR:0002804
Phosphorylation of Forkhead box transcription factor by AKT in inner space of nucleus
event
IEV:0003659
Phosphorylation of FOXO by AKT in inner space of nucleus
IEV:0003650
IGS:0000028
IMR:0002804
Binding of Forkhead box domain transcription factor and responsive element in inner space of nucleus
event
IEV:0003660
Binding of FOXO and responsive element in inner space of nucleus
IEV:0003651
IMR:0002804
Transcription of Forkhead box transcription factor target gene in nucleus
event
IEV:0003661
Transcription of FOXO target gene in nucleus
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
GO:0003012
event
IEV:0003662
Muscle system process
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
GO:0003012
IMR:0002804
UniProt:Q969P5
event
IEV:0003663
Gene expression of MAFbx by FOXO
IMR:0002804
UniProt:Q969Q1
event
IEV:0003664
Gene expression of MuRF1 by FOXO
UniProt:Q969P5
event
IEV:0003665
Transcription of MAFbx in nucleus
UniProt:Q969Q1
event
IEV:0003666
Transcription of MuRF1 in nucleus
IMR:0002721
IMR:0002730
IMR:0002736
IMR:0002823
Binding of TOR:LST8:Raptor and PRAS40 in cytosol
event
IEV:0003667
Binding of TORC1 and PRAS40 in cytosol
IMR:0000250
IMR:0002823
event
IEV:0003668
Phosphorylation of PRAS40 by AKT in cytosol
IMR:0002721
IMR:0002730
IMR:0002736
IMR:0002826
Binding of TOR:LST8:Raptor and FKBP38 in cytosol
event
IEV:0003669
Binding of TORC1 and FKBP38 in cytosol
IMR:0002721
IMR:0002736
IMR:0002742
IMR:0002747
IMR:0002759
IMR:0002764
Binding of TSC1:TSC2 complex and TOR:LST8:SIN1:Rictor in cytosol
event
IEV:0003670
Binding of TSC1:TSC2 complex and TORC2 in cytosol
A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
GO:0014732
event
IEV:0003671
Skeletal muscle atrophy
A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
GO:0014732
IMR:0000898
IMR:0011155
event
IEV:0003672
Dissociation of 4EBP and eIF4E in cytosol
IMR:0000898
IMR:0002804
event
IEV:0003673
Gene expression of 4EBP by FOXO
IEV:0003657
IMR:0000250
IMR:0002804
Negative regulation of Forkhead box transcription factor-mediated transcription by AKT
event
IEV:0003674
Negative regulation of FOXO-mediated transcription by AKT
IEV:0003654
IMR:0002804
Nuclear export of Forkhead box transcription factor
event
IEV:0003675
Nuclear export of FOXO
IMR:0000898
event
IEV:0003676
Transcription of 4EBP in nucleus
IMR:0002764
event
IEV:0003677
Binding of Melted and TSC1 in cytosol
event
IEV:0003678
Regulation of AKT(PKB)-TOR signaling
event
IEV:0003679
Negative regulation of AKT(PKB)-TOR signaling
event
IEV:0003680
Positive regulation of AKT(PKB)-TOR signaling
Any process that modulates the frequency, rate or extent of a signaling pathway.
GO:0035466
event
IEV:0003681
signal transduction regulation pathway
Any process that modulates the frequency, rate or extent of a signaling pathway.
GO:0035466
event
IEV:0003682
Regulation of G alpha-GTP hydrolysis signaling
IMR:0000250
IMR:0002804
event
IEV:0003683
Phosphorylation of FOXO by AKT in cytosol
event
IEV:0003684
Insulin receptor family signaling pathway
IMR:0002730
event
IEV:0003685
Transcription of Raptor gene in nucleus
IMR:0000374
IMR:0002932
event
IEV:0003686
Gene expression of vvl by STAT dimer
IMR:0000374
IMR:0002932
event
IEV:0003687
Transcription of vvl by STAT dimer in nucleus
IMR:0002932
event
IEV:0003688
Nuclear export of mRNA (vvl)
IMR:0002932
event
IEV:0003689
Translation of vvl in cytosol
IMR:0002914
event
IEV:0003690
Binding of trans-activator and PIAS in inner space of nucleus
IMR:0000374
IMR:0002914
event
IEV:0003691
Binding of STAT and PIAS in inner space of nucleus
IMR:0000374
IMR:0002914
event
IEV:0003692
Binding of STAT and PIAS in cytosol
IMR:0000417
event
IEV:0003693
Negative regulation of transcription by BCL-6
IGS:0000018
IMR:0000417
event
IEV:0003694
Binding of BCL-6 and GAS in inner space of nucleus
event
IEV:0003695
Negative regulation of transcription in JAK STAT pathway
IMR:0002914
event
IEV:0003696
Binding of trans-activator and PIAS in cytosol
IMR:0000081
IMR:0100278
event
IEV:0003697
Binding of TGF alpha and EGFR in extracellular
IMR:0000397
PubMed:11175369
PubMed:11715049
PubMed:9570133
event
IEV:0003698
Gene expression by ets domain transcription factor
IMR:0000399
IMR:0000400
event
IEV:0003699
Gene expression by ETS1/2
IMR:0001094
event
IEV:0003700
Gene expression by Elk-1
event
IEV:0003701
Negative regulation of FGFR1 signaling pathway
Dually phosphorylated MAPK, or dpERK, phosphorylates protein targets in both the cytoplasm and nucleus.
IMR:0000224
IMR:0000369
event
IEV:0003702
Phosphorylation of transcriptional regulator by MAPK_p in cytosol
Dually phosphorylated MAPK, or dpERK, phosphorylates protein targets in both the cytoplasm and nucleus.
PubMed:16771628
IMR:0000399
IMR:0002987
event
IEV:0003703
Gene expression of Mae by ETS1
IMR:0002987
event
IEV:0003704
Nuclear export of mRNA (Mae)
IMR:0002987
event
IEV:0003705
Transcription of Mae gene in nucleus
IMR:0002987
event
IEV:0003706
Translation of Mae in cytosol
IMR:0000227
IMR:0002980
event
IEV:0003707
Phosphorylation of Tel-1 by ERK1/2_p in inner space of nucleus
IGS:0000028
IMR:0002980
event
IEV:0003708
Binding of Tel-1 and responsive element in inner space of nucleus
IMR:0002980
event
IEV:0003709
Negative regulation of transcription by Tel-1
event
IEV:0003710
Degradation
IMR:0002965
IMR:0100278
event
IEV:0003711
Binding TGF alpha and Star in extracellular
IMR:0002965
IMR:0100278
event
IEV:0003712
Translocation of TGF alpha:Star from ER to Golgi
IMR:0002959
IMR:0100278
event
IEV:0003713
Cleavage of TGF alpha by Rhomboid in Golgi
event
IEV:0003714
Cleavage in Golgi
IMR:0100278
event
IEV:0003715
Translocation of TGF alpha from Golgi to extracellular
event
IEV:0003716
Translocation from Golgi to extracellular
IMR:0000399
IMR:0000400
IMR:0002072
event
IEV:0003717
Gene expression of Sprouty by ETS1/2
IMR:0002072
event
IEV:0003718
Nuclear export of mRNA (Sprouty)
IMR:0002072
event
IEV:0003719
Transcription of Sprouty gene in nucleus
IMR:0002072
event
IEV:0003720
Translation of Sprouty in cytosol
IMR:0000399
IMR:0002967
event
IEV:0003721
Gene expression of Argos by ETS1
IMR:0002967
event
IEV:0003722
Transcription of Argos gene in nucleus
IMR:0002967
event
IEV:0003723
Nuclear export of mRNA (Argos)
IMR:0002967
event
IEV:0003724
Translation of Argos gene in cytosol
IMR:0000399
IMR:0002988
event
IEV:0003725
Gene expression of Kek by ETS1
IMR:0002988
event
IEV:0003726
Transcription of Kek gene in nucleus
IMR:0002988
event
IEV:0003727
Nuclear export of mRNA (Kek)
IMR:0002988
event
IEV:0003728
Translation of Kek gene in cytosol
IMR:0001090
IMR:0002980
event
IEV:0003729
Binding of Tel-1 and Crm1 in inner space of nucleus
IMR:0001090
IMR:0002980
event
IEV:0003730
Nuclear export of Tel-1:Crm1
IMR:0000081
IMR:0002988
event
IEV:0003731
Binding of EGFR and Kek in plasma membrane
IMR:0002988
event
IEV:0003732
Translocation of Kek from cytosol to plasma membrane
IMR:0002072
event
IEV:0003733
Negative feedback regulation of EGF receptor signaling by Sprouty
IMR:0002988
event
IEV:0003734
Negative feedback regulation of EGF receptor signaling by Kek
IMR:0002967
event
IEV:0003735
Negative feedback regulation of EGF receptor signaling by Argos
IMR:0002967
event
IEV:0003736
Translocation of Argos from the cytosol to the extracellular
IMR:0002967
IMR:0100278
event
IEV:0003737
Binding of Argos and TGF alpha in extracellular
IMR:0000081
IMR:0002072
event
IEV:0003738
Phosphorylation of Sprouty by EGFR in cytosol
IMR:0000356
IMR:0002072
event
IEV:0003739
Binding of Sprouty and cbl in cytosol
IMR:0002072
event
IEV:0003740
Proteasome degradation of Sprouty in cytosol
IMR:0000340
IMR:0002072
event
IEV:0003741
Binding of Sprouty and Grb2 in cytosol
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
GO:0001654
event
IEV:0003742
Eye development
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
GO:0001654
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure.
GO:0048749
compound eye development (sensu Endopterygota)
eye development (sensu Endopterygota)
insect-type retina development
event
IEV:0003743
Compound eye development
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure.
GO:0048749
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
GO:0040025
vulval development (sensu Nematoda)
event
IEV:0003744
Vulval development
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
GO:0040025
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
GO:0007275
event
IEV:0003745
Multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
GO:0007275
The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of any animal when more or less of a metamorphosis takes place, before the assumption of the mature shape.
GO:0002164
event
IEV:0003746
Larval development
The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of any animal when more or less of a metamorphosis takes place, before the assumption of the mature shape.
GO:0002164
The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
GO:0048609
organismal reproductive process
event
IEV:0003747
Reproductive process in a multicellular organism
The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
GO:0048609
The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
GO:0032504
event
IEV:0003748
Multicellular organism reproduction
The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
GO:0032504
The release of a mature ovum/oocyte from an ovary.
GO:0030728
event
IEV:0003749
Ovulation
The release of a mature ovum/oocyte from an ovary.
GO:0030728
IMR:0000249
IMR:0100802
event
IEV:0003750
Phosphorylation of Smo by PKA in cytosol
IMR:0100802
IMR:0100809
event
IEV:0003751
Phosphorylation of Smo by CK1 in cytosol
IMR:0100802
event
IEV:0003752
Translocation of Smo from endosome to plasma membrane
IMR:0002955
IMR:0100802
event
IEV:0003753
Phosphorylation of Smo by GRK2 in cytosol
IMR:0002957
IMR:0100802
event
IEV:0003754
Binding of Smo and beta-arrestin2 in cytosol
event
IEV:0003755
Translocation into the cilia
IMR:0100802
event
IEV:0003756
Translocation of Smo into the cilia
IMR:0000249
IMR:0000257
IMR:0001372
IMR:0100806
IMR:0100807
IMR:0100809
event
IEV:0003757
Binding of Cos2, Fu, Ci/Gli, PKA, GSK3 and CK1 in cytosol
IMR:0001372
IMR:0100470
event
IEV:0003758
Ubiquitination of Ci/Gli by SCF ubiquitin ligase complex in cytosol
Any process that modulates the frequency, rate or extent of smoothened signaling.
GO:0008589
regulation of smoothened signalling pathway
event
IEV:0003759
Regulation of Hedgehog signaling pathway
Any process that modulates the frequency, rate or extent of smoothened signaling.
GO:0008589
regulation of smoothened signalling pathway
GO:0008589
Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling.
GO:0045879
down regulation of smoothened signaling pathway
down-regulation of smoothened signaling pathway
downregulation of smoothened signaling pathway
negative regulation of smoothened signalling pathway
event
IEV:0003760
Negative regulation of Hedgehog signaling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling.
GO:0045879
IMR:0000004
IMR:0002945
event
IEV:0003761
Binding of Hedgehog and Hip in extracellular
IMR:0000004
IMR:0002933
event
IEV:0003762
Binding of Hedgehog and Ihog/Boi/Cdo/Boc in extracellular
IMR:0100802
event
IEV:0003763
Translocation of Smo from plasma membrane to endosome
event
IEV:0003764
Translocation from plasma membrane to endosome
event
IEV:0003765
Degradation in lysosome
IMR:0100802
event
IEV:0003766
Degradation of Smo in lysosome
IMR:0000249
IMR:0000257
IMR:0001372
IMR:0100806
IMR:0100807
IMR:0100809
event
IEV:0003767
Dissociation of Cos2:Fu:Ci/Gli and PKA, GSK3, CK1 in cytosol
IMR:0100806
event
IEV:0003768
Autophosphorylation of Fu in cytosol
IMR:0100806
IMR:0100807
event
IEV:0003769
Phosphorylation of Cos2 by Fu in cytosol
IMR:0003011
IMR:0100806
event
IEV:0003770
Phosphorylation of Sufu by Fu in cytosol
IMR:0001372
IMR:0003011
event
IEV:0003771
Dissociation of Sufu and Ci/Gli in cytosol
IMR:0001372
IMR:0100802
IMR:0100806
IMR:0100807
Dissociation of Ci/Gli from Smo:Cos2:Fu:Ci/Gli in cytosol
event
IEV:0003772
Dissociation of Ci/Gli and Smo:Cos2:Fu in cytosol
IGS:0000029
IMR:0000426
IMR:0001372
event
IEV:0003773
Binding of Ci/Gli, CBP and Hedgehog target gene promoter in inner space of nucleus
IGS:0000029
IMR:0000426
IMR:0001372
IMR:0001981
event
IEV:0003774
Binding of Ci/Gli, CBP and dpp gene promoter in inner space of nucleus
IGS:0000029
IMR:0000141
IMR:0000426
IMR:0001372
event
IEV:0003775
Binding of Ci/Gli, CBP and ptc gene promoter in inner space of nucleus
IMR:0001363
event
IEV:0003776
Transcription of Gli1 gene in nucleus
IGS:0000029
IMR:0001372
event
IEV:0003777
Binding of Ci/GliR and Hedgehog target gene promoter in inner space of nucleus
IMR:0001372
event
IEV:0003778
Gene expression by Ci/Gli
It is further processed by internal cleavage to generate a 19-kDa N-terminal fragment (N-Hh) and a 25-kDa C-terminal fragment (C-Hh) with the concomitant addition of cholesterol at the C-terminus of N-Hh (N-Hhchol).
IEV:0002577
IEV:0002578
IMR:0000004
IMR:0200486
PubMed:12208857
Autocleavage of hedgehog in ER
Cholesterol modification of hedgehog in ER
event
IEV:0003779
Autocleavage and cholesterol modification of Hedgehog in ER
It is further processed by internal cleavage to generate a 19-kDa N-terminal fragment (N-Hh) and a 25-kDa C-terminal fragment (C-Hh) with the concomitant addition of cholesterol at the C-terminus of N-Hh (N-Hhchol).
PubMed:12208857
It is further processed by internal cleavage to generate a 19-kDa N-terminal fragment (N-Hh) and a 25-kDa C-terminal fragment (C-Hh) with the concomitant addition of cholesterol at the C-terminus of N-Hh (N-Hhchol).
MOD:00314
PubMed:12208857
event
IEV:0003780
Hedgehog cleavage and lipidation
It is further processed by internal cleavage to generate a 19-kDa N-terminal fragment (N-Hh) and a 25-kDa C-terminal fragment (C-Hh) with the concomitant addition of cholesterol at the C-terminus of N-Hh (N-Hhchol).
PubMed:12208857
IMR:0000080
IMR:0000399
event
IEV:0003781
Gene expression of FGF receptor by ETS1
IMR:0000080
event
IEV:0003782
Transcription of FGF receptor gene in nucleus
IMR:0000080
event
IEV:0003783
Nuclear export of mRNA (FGF receptor)
IMR:0000080
event
IEV:0003784
Translation of FGF receptor gene in cytosol
IMR:0000399
IMR:0002996
event
IEV:0003785
Gene expression of SRF by ETS1
IMR:0002996
event
IEV:0003786
Transcription of SRF gene in nucleus
IMR:0002996
event
IEV:0003787
Nuclear export of mRNA (SRF)
IMR:0002996
event
IEV:0003788
Translation of SRF gene in cytosol
IMR:0000080
event
IEV:0003789
Translocation of FGF receptor from cytosol to plasma membrane
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
GO:0007509
event
IEV:0003790
Mesoderm migration
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
GO:0007509
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
GO:0007424
event
IEV:0003791
Open tracheal system development
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
GO:0007424
The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.
GO:0060541
event
IEV:0003792
Respiratory system development
The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.
GO:0060541
The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.
GO:0060438
event
IEV:0003793
Trachea development
The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.
GO:0060438
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
GO:0048731
event
IEV:0003794
System development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
GO:0048731
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
GO:0048856
event
IEV:0003795
Anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
GO:0048856
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
GO:0009888
histogenesis
event
IEV:0003796
Tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
GO:0009888
The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
GO:0048608
event
IEV:0003797
Reproductive structure development
The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
GO:0048608
The establishment of the sex of an organism by physical differentiation.
GO:0007548
event
IEV:0003798
Sex differentiation
The establishment of the sex of an organism by physical differentiation.
GO:0007548
A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
GO:0003006
event
IEV:0003799
Reproductive developmental process
A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
GO:0003006
IMR:0000080
IMR:0000340
event
IEV:0003800
Binding of FGFR and Grb2 in cytosol
Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
GO:0040037
down regulation of fibroblast growth factor receptor signaling pathway
down-regulation of fibroblast growth factor receptor signaling pathway
downregulation of fibroblast growth factor receptor signaling pathway
negative regulation of FGF receptor signalling pathway
negative regulation of FGFR signaling pathway
event
IEV:0003801
Negative regulation of FGF receptor signaling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
GO:0040037
down regulation of fibroblast growth factor receptor signaling pathway
GO:0040037
down-regulation of fibroblast growth factor receptor signaling pathway
GO:0040037
downregulation of fibroblast growth factor receptor signaling pathway
GO:0040037
negative regulation of FGF receptor signalling pathway
GO:0040037
negative regulation of FGFR signaling pathway
GO:0040037
IMR:0000080
IMR:0003010
event
IEV:0003802
Dephosphorylation of FGFR by CLR-1 in cytosol
A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase.
GO:0070375
BMK1 cascade
ERK5 cascade
MAPK7 cascade
event
IEV:0003803
BMK cascade
A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase.
GO:0070375
Grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
GO:0043113
event
IEV:0003804
receptor clustering
Grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
GO:0043113
The biosynthetic process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.
GO:0019184
nonribosomal peptide anabolism
nonribosomal peptide biosynthetic process
nonribosomal peptide formation
nonribosomal peptide synthesis
event
IEV:0003805
Nonribosomal peptide biosynthesis
The biosynthetic process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.
GO:0019184
The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
GO:0006836
event
IEV:0003806
Neurotransmitter transport
The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
GO:0006836
Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
GO:0048511
event
IEV:0003807
Rhythmic process
Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
GO:0048511
The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours.
GO:0048512
circadian rhythm behavior
event
IEV:0003808
Circadian behavior
The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours.
GO:0048512
event
IEV:0003809
Receptor recycling mediated signaling
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0019752
carboxylic acid metabolic process
event
IEV:0003810
Carboxylic acid metabolism
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0019752
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
GO:0006066
alcohol metabolic process
event
IEV:0003811
Alcohol metabolism
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
GO:0006066
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
GO:0006519
cellular amino acid and derivative metabolic process
event
IEV:0003812
Amino acid and derivative metabolism
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
GO:0006519
The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.
GO:0043603
cellular amide metabolic process
event
IEV:0003813
Amide metabolism
The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.
GO:0043603
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0006139
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
event
IEV:0003814
Nucleobase, nucleoside, nucleotide and nucleic acid metabolism
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0006139
CoA biosynthesis: The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
GO:0015937
KEGG:map00770
coenzyme A anabolism
coenzyme A biosynthesis
coenzyme A biosynthetic process
coenzyme A formation
coenzyme A synthesis
event
IEV:0003815
CoA biosynthesis
CoA biosynthesis: The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
GO:0015937
IMR:0000063
IMR:0000285
event
IEV:0003816
Phosphorylation of PLC gamma by receptor tyrosine kinase in cytosol
IMR:0000210
IMR:0000285
PubMed:10579907
event
IEV:0003817
Phosphorylation of PLC gamma by tyrosine kinase in cytosol
IMR:0000068
IMR:0000732
event
IEV:0003818
Phosphorylation of PLC gamma1 by PDGF receptor in cytosol
IMR:0000210
IMR:0000284
event
IEV:0003819
Phosphorylation of PLC by tyrosine kinase in cytosol
IMR:0000210
IMR:0000284
event
IEV:0003820
Binding of PLC and tyrosine kinase in cytosol
IMR:0000068
IMR:0000732
event
IEV:0003821
Binding of PDGF receptor_p and PLC gamma1 in cytosol
IMR:0000210
IMR:0000285
event
IEV:0003822
Binding of PLC gamma and tyrosine kinase in cytosol
IMR:0000080
IMR:0002990
event
IEV:0003823
Binding of FGFR and Dof in cytosol
IMR:0000080
IMR:0000333
event
IEV:0003824
Binding of FGFR and adaptor protein in cytosol
IMR:0000080
IMR:0000333
event
IEV:0003825
Phosphorylation of adaptor protein by FGFR in cytosol
IMR:0000080
IMR:0002990
event
IEV:0003826
Phosphorylation of Dof by FGFR in cytosol
IMR:0000276
IMR:0002990
event
IEV:0003827
Binding of Dof and SHP-2 in cytosol
IMR:0000288
IMR:0000442
IMR:0001354
event
IEV:0003828
Hydrolysis of GTP by small GTPase and GAP in cytosol
IMR:0001354
event
IEV:0003829
Hydrolysis of GTP by trimeric G-protein in cytosol
IMR:0000290
IMR:0000443
IMR:0001354
event
IEV:0003830
Hydrolysis of GTP by Ras and RasGAP in cytosol
IMR:0000290
IMR:0001354
IMR:0001357
IMR:0002063
event
IEV:0003831
GDP-GTP exchange of Ras by Sos1 in cytosol
IMR:0000068
IMR:0000276
event
IEV:0003832
Dephosphorylation of PDGF receptor by SHP-2 in cytosol
IMR:0000290
IMR:0001354
IMR:0100355
event
IEV:0003833
Binding of Ras-GTP and Raf1 in cytosol
IMR:0000227
IMR:0001095
event
IEV:0003834
Phosphorylation of Sap-1 by ERK1/2_p in inner space of nucleus
IMR:0002957
IMR:0003014
IMR:0100802
event
IEV:0003835
Binding of Smo:beta-arrestin 2 and Kif3A in cytosol
IMR:0100742
event
IEV:0003836
Movement of Ptc1 out of the cilia
event
IEV:0003837
Translocation out of the cilia
IMR:0000343
IMR:0100356
event
IEV:0003838
Binding of Nck and PAK1 in cytosol
IMR:0000699
IMR:0001354
IMR:0001357
UniProt:Q15052
event
IEV:0003839
GDP-GTP exchange of Cdc42 by RhoGEF6 in cytosol
IMR:0100356
UniProt:Q15052
event
IEV:0003840
Binding of PAK1 and RhoGEF6 in cytosol
EC:2.6.1.81
IMR:0100119
IMR:0200013
IMR:0200369
IMR:0200480
KEGG:R04217
KEGG:map00330
event
IEV:0003841
2-Oxo-glutaric acid + N2-Succinyl-L-ornithine = L-Glutamic acid + N-Succinyl-L-glutamate 5-semialdehyde( EC:2.6.1.81 )
EC:1.1.1.153
IMR:0200030
IMR:0200067
IMR:0200209
IMR:0200463
KEGG:C04244
KEGG:R01813
KEGG:map00790
event
IEV:0003842
Tetrahydrobiopterin + NADP+ = 6-Lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+( EC:1.1.1.153 )
EC:1.1.1.153
IMR:0200030
IMR:0200063
IMR:0200067
IMR:0200463
KEGG:C04244
KEGG:R04285
KEGG:map00790
event
IEV:0003843
6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ = 6-Pyruvoyltetrahydropterin + NADPH + H+( EC:1.1.1.153 )
EC:3.5.4.16
IMR:0001354
IMR:0200357
KEGG:C05922
KEGG:R00428
KEGG:map00790
event
IEV:0003844
subsequently IEV:0003845
GTP + H2O = Formamidopyrimidine nucleoside triphosphate( EC:3.5.4.16 )
EC:3.5.4.16
IMR:0200110
IMR:0200357
KEGG:C05922
KEGG:C05923
KEGG:R05046
KEGG:map00790
event
IEV:0003845
subsequently IEV:0003846
Formamidopyrimidine nucleoside triphosphate + H2O = 2,5-Diaminopyrimidine nucleoside triphosphate + Formic acid( EC:3.5.4.16 )
EC:3.5.4.16
KEGG:C05923
KEGG:C06148
KEGG:R05048
KEGG:map00790
event
IEV:0003846
subsequently IEV:0003847
2,5-Diaminopyrimidine nucleoside triphosphate = 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine( EC:3.5.4.16 )
EC:3.5.4.16
IMR:0200357
IMR:0200406
KEGG:C06148
KEGG:R04639
KEGG:map00790
event
IEV:0003847
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + H2O = 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine( EC:3.5.4.16 )
EC:2.6.1.44
IMR:0100118
IMR:0100119
IMR:0200184
IMR:0200480
KEGG:R00372
KEGG:map00260
event
IEV:0003848
L-Glutamate + Glyoxylic acid = 2-Oxo-glutaric acid + Glycine( EC:2.6.1.44 )
EC:6.2.1.1
IMR:0001351
IMR:0200081
IMR:0200280
KEGG:C05983
KEGG:R01354
KEGG:map00640
event
IEV:0003849
subsequently IEV:0003850
ATP + Propanoic acid = Diphosphate + Propionyladenylate( EC:6.2.1.1 )
EC:6.2.1.1
IMR:0200083
IMR:0200354
IMR:0200484
KEGG:C05983
KEGG:R00926
KEGG:map00640
event
IEV:0003850
Propionyladenylate + CoA = AMP + Propanoyl-CoA( EC:6.2.1.1 )
EC:1.13.11.34
IMR:0200212
IMR:0200217
IMR:0200357
IMR:0200461
KEGG:R08527
event
IEV:0003851
two-step reaction
Arachidonic acid + O2 = Leukotriene A4 + H2O( EC:1.13.11.34 )
EC:1.14.99.1
IMR:0200212
IMR:0200217
IMR:0200224
IMR:0200253
IMR:0200300
IMR:0200357
KEGG:R01599
event
IEV:0003852
multi-step reaction
Arachidonic acid + Reduced acceptor + 2 O2 = Prostaglandin H2 + Acceptor + H2O( EC:1.14.99.1 )
EC:6.2.1.1
IMR:0001351
IMR:0200208
IMR:0200280
KEGG:C05993
KEGG:R00316
KEGG:map00620
event
IEV:0003853
subsequently IEV:0003854
ATP + Acetic acid = Pyrophosphate + Acetyl adenylate( EC:6.2.1.1 )
EC:6.2.1.1
IMR:0200083
IMR:0200354
IMR:0200414
KEGG:C05993
KEGG:R00236
KEGG:map00620
event
IEV:0003854
Acetyl adenylate + CoA = AMP + Acetyl-CoA( EC:6.2.1.1 )
EC:1.14.13.39
IMR:0200030
IMR:0200067
IMR:0200217
IMR:0200357
IMR:0200428
IMR:0200463
KEGG:C05933
KEGG:R00558
KEGG:map00330
event
IEV:0003855
subsequently IEV:0003856
L-Arginine + O2 + NADPH + H+ = N-(omega)-Hydroxyarginine + NADP+ + H2O( EC:1.14.13.39 )
EC:1.14.13.39
IMR:0100128
IMR:0200019
IMR:0200030
IMR:0200067
IMR:0200217
IMR:0200357
IMR:0200463
KEGG:C05933
KEGG:R00111
KEGG:map00330
event
IEV:0003856
NADPH + 2 N-(omega)-Hydroxyarginine + 2 O2 + H+ = NADP+ + 2 Nitric oxide + 2 L-Citrulline + 2 H2O( EC:1.14.13.39 )
EC:6.3.5.5
IMR:0100119
IMR:0200075
IMR:0200357
IMR:0200448
KEGG:R00256
KEGG:map00250
KEGG:map00330
KEGG:map00471
KEGG:map00910
event
IEV:0003857
the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor
L-Glutamine + H2O = L-Glutamate + NH3( EC:6.3.5.5 )
EC:6.3.5.5
IMR:0001351
IMR:0001360
IMR:0200075
IMR:0200102
IMR:0200109
KEGG:C00288
KEGG:R07641
event
IEV:0003858
multi-step reaction
2 ATP + HCO3- + NH3 = 2 ADP + Orthophosphate + Carbamoyl phosphate( EC:6.3.5.5 )
IMR:0000382
event
IEV:0003859
Activation of NF-kappaB in cytosol
IMR:0100596
IMR:0100606
event
IEV:0003860
Binding of CDK and cyclin in cytosol
event
IEV:0003861
Negative regulation of G1 phase
IMR:0000324
IMR:0001354
event
IEV:0003862
Binding of G alpha 12/13-GTP and effector in cytosol
IMR:0000447
event
IEV:0003863
Nuclear export of mRNA (INK4 family)
IMR:0000446
event
IEV:0003864
Nuclear export of mRNA (Cip/Kip family)
IMR:0000445
event
IEV:0003865
Nuclear export of mRNA (CKI)
IMR:0000370
IMR:0000445
event
IEV:0003866
Transcription of CKI by Smad complex in nucleus
IMR:0000445
event
IEV:0003867
Translation of CKI in cytosol
IGS:0000028
IMR:0000399
event
IEV:0003868
Binding of ETS1_p and responsive element in inner space of nucleus
IMR:0000227
IMR:0000397
event
IEV:0003869
Phosphorylation of ets domain transcription factor by ERK_p in inner space of nucleus
IMR:0000177
IMR:0000205
IMR:0000432
IMR:0100737
event
IEV:0003870
Dissociation of Axin, APC, GSK3beta and beta-catenin in cytosol
The expansion of a B cell population by cell division. Follows B cell activation.
GO:0042100
B lymphocyte proliferation
B-cell proliferation
B-lymphocyte proliferation
event
IEV:0003871
B cell proliferation
The expansion of a B cell population by cell division. Follows B cell activation.
GO:0042100
The expansion of a T cell population by cell division. Follows T cell activation.
GO:0042098
T lymphocyte proliferation
T-cell proliferation
T-lymphocyte proliferation
event
IEV:0003872
T cell proliferation
The expansion of a T cell population by cell division. Follows T cell activation.
GO:0042098
event
IEV:0003873
Th2 cell proliferation
event
IEV:0003874
Th1 cell proliferation
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
GO:0030217
T lymphocyte differentiation
T-cell differentiation
T-lymphocyte differentiation
event
IEV:0003875
T cell differentiation
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
GO:0030217
event
IEV:0003876
Th1 cell differentiation
event
IEV:0003877
Th2 cell differentiation
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
GO:0001775
event
IEV:0003878
Cell activation
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
GO:0001775
A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
GO:0046649
event
IEV:0003879
lymphocyte activation
A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
GO:0046649
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
GO:0030101
natural killer cell activation
event
IEV:0003880
NK cell activation
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
GO:0030101
Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift.
GO:0007378
event
IEV:0003881
Amnioserosa formation
Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift.
GO:0007378
The formation of ectoderm during gastrulation.
GO:0001705
event
IEV:0003882
Ectoderm formation
The formation of ectoderm during gastrulation.
GO:0001705
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
GO:0007398
event
IEV:0003883
Ectoderm development
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
GO:0007398
IMR:0000040
event
IEV:0003884
Complex formation of BMP in ER
IMR:0000040
event
IEV:0003885
Translocation of BMP from ER to plasma membrane
IMR:0000040
IMR:0003020
IMR:0003022
event
IEV:0003886
Binding of Tsg, Chordin and BMP in extracellular
IMR:0000040
event
IEV:0003887
Translocation of BMP to the dorsal midline
event
IEV:0003888
Translocation in extracellular
event
IEV:0003889
Cleavage of Chordin by Tld in extracellular
IMR:0100356
event
IEV:0003890
Autophosphorylation of PAK1 in cytosol
IMR:0000242
IMR:0000343
event
IEV:0003891
Binding of Nck and NIK in cytosol
IMR:0000699
IMR:0100356
event
IEV:0003892
Binding of PAK1 and Cdc42 and conformational change of PAK1 in cytosol
IMR:0100356
event
IEV:0003893
Dissociation of PAK1 in cytosol
IMR:0000068
IMR:0000335
event
IEV:0003894
Binding of PDGF receptor and Crk in cytosol
IMR:0000068
IMR:0000265
event
IEV:0003895
Binding of PDGF receptor and PI3K in cytosol
IMR:0000068
IMR:0000276
event
IEV:0003896
Binding of PDGF receptor and SHP-2 in cytosol
IMR:0000068
IMR:0000343
event
IEV:0003897
Binding of PDGF receptor and Nck in cytosol
IMR:0000068
IMR:0100431
event
IEV:0003898
Binding of PDGF receptor and RasGAP in cytosol
IMR:0000068
IMR:0100733
event
IEV:0003899
Binding of PDGF receptor and STAT5 in cytosol
IMR:0000068
IMR:0000732
event
IEV:0003900
Dissociation of PDGF receptor and PLC gamma1 in cytosol
IMR:0000068
IMR:0100733
event
IEV:0003901
Dissociation of PDGF receptor and STAT5 in cytosol
IMR:0000068
IMR:0000343
event
IEV:0003902
Phosphorylation of Nck by PDGF receptor in cytosol
IMR:0100355
IMR:0100356
event
IEV:0003903
Phosphorylation of Raf1 by PAK1 in cytosol
IMR:0000068
IMR:0100733
event
IEV:0003904
Phosphorylation of STAT5 by PDGF receptor in cytosol
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
GO:0030324
event
IEV:0003905
Lung development
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
GO:0030324
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
GO:0043588
event
IEV:0003906
Skin development
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
GO:0043588
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
GO:0008584
event
IEV:0003907
Male gonad development
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
GO:0008584
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0006935
taxis in response to chemical stimulus
event
IEV:0003908
chemotaxis
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0006935
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
GO:0007067
event
IEV:0003909
mitosis
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
GO:0007067
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
GO:0030855
event
IEV:0003910
Epithelial cell differentiation
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
GO:0030855
The process in which a mesodermal angioblast acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
GO:0045446
event
IEV:0003911
Endothelial cell differentiation
The process in which a mesodermal angioblast acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
GO:0045446
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
GO:0060429
event
IEV:0003912
Epithelium development
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
GO:0060429
The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. An endothelium is an epithelium that lines an anatomical structure.
GO:0003158
event
IEV:0003913
Endothelium development
The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. An endothelium is an epithelium that lines an anatomical structure.
GO:0003158
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
GO:0008544
event
IEV:0003914
Epidermis development
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
GO:0008544
The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities.
GO:0060021
palatum development
event
IEV:0003915
Palate development
The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities.
GO:0060021
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
GO:0010001
glia cell differentiation
event
IEV:0003916
Glial cell differentiation
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
GO:0010001
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
GO:0014003
oligodendrocyte cell development
event
IEV:0003917
Oligodendrocyte development
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
GO:0014003
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
GO:0048514
event
IEV:0003918
Blood vessel morphogenesis
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
GO:0048514
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
GO:0048844
arterial morphogenesis
arteriogenesis
event
IEV:0003919
Artery morphogenesis
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
GO:0048844
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
GO:0001525
blood vessel formation from pre-existing blood vessels
event
IEV:0003920
angiogenesis
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
GO:0001525