* MPATH:$sequence(3,0,999)$
OBO-Edit 2.3-beta5
mouse_pathology.ontology
1.2
ORCID: 0000-0002-5111-7263
The Pathbase mouse pathology ontology provides a description of experimental mouse pathology phenotypes and incorporates 889 concepts including anatomical pathological entities and pathological processes. These are organised in an almost entirely is_a hierarchy of pathological processes or anatomical entities. Questions, comments and suggestions for amendment should be sent to the Co-ordinator, Dr. Paul Schofield, Dept. of Physiology Development and Neuroscience, University of Cambridge (PNS12@cam.ac.uk).The ontology was developed by the Pathbase consortium (http://www.pathbase.net) funded under the European Commission's Fifth Framework programme, Contract number QLRI-CT-1999-00320.
definition
namespace-id-rule
has_alternative_id
has_broad_synonym
database_cross_reference
has_exact_synonym
has_obo_format_version
has_obo_namespace
has_related_synonym
mouse_pathology.ontology
is_a
is a
mouse_pathology.ontology
part_of
part of
Pathological structure or process
mouse_pathology.ontology
MPATH:0
pathological entity
Pathological structure or process
Pathbase: Curation
The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors.
mouse_pathology.ontology
MPATH:1
cell and tissue damage
The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors.
Pathbase: Pathology Committee
Extensive necrosis from whatever cause, often following chronic ischemia.
mouse_pathology.ontology
Mortification
MPATH:10
gangrene
Extensive necrosis from whatever cause, often following chronic ischemia.
ISBN:0781727286
Mortification
Pathbase: Curation
Defect in placental growth, differentiation of circulation; maternal or embryonic component.
mouse_pathology.ontology
MPATH:100
placental abnormality
Defect in placental growth, differentiation of circulation; maternal or embryonic component.
Pathbase: Pathology Committee
Phenotypic observation of the presence or absence of a pathological entity.
Luke Slater
mouse_pathology.ontology
MPATH:1000
pathological phenotype observation
Phenotypic observation of the presence or absence of a pathological entity.
UOB:LTS
Lack of, displacement of, or abnormality in function or growth of the glycogen cells.
mouse_pathology.ontology
MPATH:101
glycogen cell defect
Lack of, displacement of, or abnormality in function or growth of the glycogen cells.
Pathbase: Curation
Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta.
mouse_pathology.ontology
MPATH:102
labyrinth zone defect
Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta.
Pathbase: Pathology Committee
Any defect in the maternal or embryonic placental circulation.
mouse_pathology.ontology
MPATH:103
placental vascular defect
Any defect in the maternal or embryonic placental circulation.
Pathbase: Curation
Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta.
mouse_pathology.ontology
MPATH:104
spongiotrophoblast defect
Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta.
Pathbase: Curation
Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body.
mouse_pathology.ontology
MPATH:105
circulatory disorder
Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body.
Pathbase: Pathology Committee
Abnormal accumulation of fluid; blood or lymph.
mouse_pathology.ontology
MPATH:106
fluid accumulation
Abnormal accumulation of fluid; blood or lymph.
Pathbase: Curation
Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ.
mouse_pathology.ontology
MPATH:107
congestion
Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ.
Pathbase: Pathology Committee
A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products.
mouse_pathology.ontology
DIC
MPATH:108
Diagnosed by microthrombi in many organs.
disseminated intravascular coagulation
A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products.
ISBN:0781727286
DIC
Pathbase: Curation
An accumulation of an excessive amount of watery fluid in cells or intercellular tissues.
oedema
mouse_pathology.ontology
MPATH:109
edema
An accumulation of an excessive amount of watery fluid in cells or intercellular tissues.
Pathbase: Curation
Necrosis associated with local hemorrhage.
mouse_pathology.ontology
MPATH:11
hemorrhagic necrosis
Necrosis associated with local hemorrhage.
ISBN:0781727286
A plug formed from a variety of materials occluding a vessel or tube.
mouse_pathology.ontology
MPATH:110
embolus
A plug formed from a variety of materials occluding a vessel or tube.
Pathbase: Pathology Committee
An bubble of air occluding flow through a blood or lymphatic vessel.
mouse_pathology.ontology
MPATH:111
air embolism
An bubble of air occluding flow through a blood or lymphatic vessel.
Pathbase: Curation
Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation.
mouse_pathology.ontology
MPATH:112
amniotic fluid embolism
Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation.
Pathbase: Curation
Occlusion of the outflow tract of the right atrium by a thrombus.
mouse_pathology.ontology
MPATH:113
atrial embolism
Occlusion of the outflow tract of the right atrium by a thrombus.
Pathbase: Curation
Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma.
mouse_pathology.ontology
MPATH:114
bone marrow embolism
Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma.
Pathbase: Pathology Committee
Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma.
mouse_pathology.ontology
MPATH:115
fat embolism
Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma.
Pathbase: Curation
Occlusion of pulmonary vessels by an embolus.
mouse_pathology.ontology
MPATH:116
pulmonary embolism
Occlusion of pulmonary vessels by an embolus.
Pathbase: Curation
Occlusion of vessels, usually small arterioles in the dermis by various emboli.
mouse_pathology.ontology
MPATH:117
skin embolism
Occlusion of vessels, usually small arterioles in the dermis by various emboli.
Pathbase: Curation
Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta.
mouse_pathology.ontology
MPATH:118
systemic embolism
Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta.
Pathbase: Pathology Committee
Abnormal release of whole blood or the cellular component from the circulation.
mouse_pathology.ontology
MPATH:119
hemorrhage and non-specified extravasation
Abnormal release of whole blood or the cellular component from the circulation.
Pathbase: Curation
Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes.
mouse_pathology.ontology
MPATH:12
liquefactive necrosis
Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes.
ISBN:0781727286
A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae.
mouse_pathology.ontology
MPATH:120
May also be used for any organ, although more generally used with respect to the skin.
ecchymosis
A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae.
ISBN:0781727286
A localised deposition of clotted or partially clotted extravasated blood.
mouse_pathology.ontology
Bruise
MPATH:121
hematoma
A localised deposition of clotted or partially clotted extravasated blood.
ISBN:0781727286
Bruise
Pathbase: Curation
Small hemorrhagic spots in the skin caused by blood vessel breakdown.
mouse_pathology.ontology
MPATH:122
Usually used with reference to the skin but can be used in the context of other organs.
petechia
Small hemorrhagic spots in the skin caused by blood vessel breakdown.
ISBN:0781727286
Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia.
mouse_pathology.ontology
MPATH:123
purpura
Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia.
ISBN:0781727286
An area of necrosis resulting from a sudden cessation of arterial or venous blood supply.
mouse_pathology.ontology
MPATH:124
infarct
An area of necrosis resulting from a sudden cessation of arterial or venous blood supply.
Pathbase: Pathology Committee
Presence of an occluding or mural thrombus in a blood vessel.
mouse_pathology.ontology
MPATH:125
thrombosis
Presence of an occluding or mural thrombus in a blood vessel.
Pathbase: Curation
Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs.
mouse_pathology.ontology
MPATH:126
growth and differentiation defect
Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs.
Pathbase: Pathology Committee
A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume.
mouse_pathology.ontology
MPATH:127
atrophy
A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume.
Pathbase: Pathology Committee
Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64.
mouse_pathology.ontology
intra-epithelial lesion
MPATH:128
This term has been previously used as a synonym for pre-malignant dysplasia or carcinoma in situ and is now to be preferred.
intra-epithelial neoplasia
Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64.
Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128
intra-epithelial lesion
Pathbase: Curation
epithelial dysplasia
mouse_pathology.ontology
MPATH:129
obsolete due to renaming of preneoplastic dysplasias and Intraepithelial neoplasias Use MPATH:128.
epithelial dysplasia
true
epithelial dysplasia
Pathbase: Pathology Committee
Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate.
mouse_pathology.ontology
MPATH:13
piecemeal necrosis
Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate.
ISBN:0781727286
Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
George Gkoutos
mouse_pathology.ontology
IENI
low grade intraepithelial lesion
mild epithelial dysplasia.
MPATH:130
mild intra-epithelial neoplasia
Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128
IENI
Pathbase: Curation
low grade intraepithelial lesion
Pathbase: Curation
mild epithelial dysplasia.
Pathbase: Curation
Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
George Gkoutos
mouse_pathology.ontology
IENII
high grade intraepithelial lesion
moderate epithelial dysplasia
MPATH:131
moderate intra-epithelial epithelial neoplasia
Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128
IENII
Pathbase: Curation
high grade intraepithelial lesion
Pathbase: Curation
moderate epithelial dysplasia
Pathbase: Curation
Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone.
George Gkoutos
mouse_pathology.ontology
IENIII
carcinoma in situ
high grade intra-epithelial lesion
severe epithelial dysplasia
MPATH:132
Carcinoma in situ may be used in some systems as a synonym.
severe intra-epithelial neoplasia
Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone.
Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128
IENIII
Pathbase: Curation
carcinoma in situ
Pathbase: Curation
high grade intra-epithelial lesion
Pathbase: Curation
severe epithelial dysplasia
Pathbase: Curation
Small organ or structure; failure to develop to normal size.
George Gkoutos
mouse_pathology.ontology
Developmental hypoplasia
MPATH:133
hypoplasia
Small organ or structure; failure to develop to normal size.
Pathbase: Pathology Committee
Developmental hypoplasia
Pathbase: Curation
An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process.
George Gkoutos
mouse_pathology.ontology
MPATH:134
hyperplasia
An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process.
Pathbase: Pathology Committee
Abnormal proliferation of epithelial and stromal cells.
George Gkoutos
mouse_pathology.ontology
MPATH:135
epithelial and stromal hyperplasia
Abnormal proliferation of epithelial and stromal cells.
Pathbase: Pathology Committee
A polypoid outgrowth of both epidermis and dermal fibrovascular tissue.
George Gkoutos
mouse_pathology.ontology
skin tag
MPATH:136
fibroepithelial polyp
A polypoid outgrowth of both epidermis and dermal fibrovascular tissue.
ISBN:0781727286
skin tag
Pathbase: Curation
Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma.
George Gkoutos
mouse_pathology.ontology
MPATH:137
fibroglandular hyperplasia
Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma.
Pathbase: Curation
Abnormal proliferation of epithelial cells and epithelial components.
George Gkoutos
mouse_pathology.ontology
MPATH:138
epithelial hyperplasia
Abnormal proliferation of epithelial cells and epithelial components.
Pathbase: Pathology Committee
Benign proliferation of goblet cells.
George Gkoutos
mouse_pathology.ontology
MPATH:139
goblet cell hyperplasia
Benign proliferation of goblet cells.
Pathbase: Curation
A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell.
George Gkoutos
mouse_pathology.ontology
MPATH:14
process of degenerative change
A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell.
Pathbase: Pathology Committee
A benign polyp, usually in the colon, showing hyperplasia.
George Gkoutos
mouse_pathology.ontology
MPATH:140
hyperplastic polyp
A benign polyp, usually in the colon, showing hyperplasia.
ISBN:0781727286
A projecting mass of granulation tissue which may become covered by regenerating epithelium.
George Gkoutos
mouse_pathology.ontology
pseudopolyp
MPATH:141
inflammatory polyp
A projecting mass of granulation tissue which may become covered by regenerating epithelium.
ISBN:0781727286
pseudopolyp
Pathbase: Curation
Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia.
George Gkoutos
mouse_pathology.ontology
MPATH:142
intraductal hyperplasia
Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia.
PMID:10713680
Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium.
George Gkoutos
mouse_pathology.ontology
microglandular adenosis
MPATH:143
microglandular hyperplasia
Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium.
ISBN:0781727286
microglandular adenosis
Pathbase: Curation
Benign proliferation of glandular myoepithelial cells.
George Gkoutos
mouse_pathology.ontology
MPATH:144
myoepithelial hyperplasia
Benign proliferation of glandular myoepithelial cells.
Pathbase: Curation
Benign proliferation of adipose tissue.
George Gkoutos
mouse_pathology.ontology
MPATH:145
fat cell hyperplasia
Benign proliferation of adipose tissue.
Pathbase: Pathology Committee
true
Benign enlargement of lymphoid tissues.
George Gkoutos
mouse_pathology.ontology
lymphoid hypertrophy
MPATH:147
lymphoid hyperplasia
Benign enlargement of lymphoid tissues.
Pathbase: Pathology Committee
lymphoid hypertrophy
Pathbase: Curation
Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm.
George Gkoutos
mouse_pathology.ontology
mesothelioma
MPATH:148
mesothelial hyperplasia
Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm.
Pathbase: Mohr
mesothelioma
Pathbase: Curation
Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia).
George Gkoutos
mouse_pathology.ontology
epidermal hyperplasia.
squamous cell hyperplasia
MPATH:149
squamous hyperplasia
Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia).
Pathbase: Pathology Committee
epidermal hyperplasia.
Pathbase: Curation
squamous cell hyperplasia
Pathbase: Curation
Change of tissue to a lower state of integrity or less functional form, as in heart failure.
George Gkoutos
mouse_pathology.ontology
MPATH:15
general degenerative process
Change of tissue to a lower state of integrity or less functional form, as in heart failure.
Pathbase: Pathology Committee
Hyperplasia of the Malpighian layer (prickle cell) of the epidermis.
George Gkoutos
mouse_pathology.ontology
MPATH:150
acanthosis
Hyperplasia of the Malpighian layer (prickle cell) of the epidermis.
ISBN:0781727286
Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date.
George Gkoutos
mouse_pathology.ontology
MPATH:151
actinic keratosis
Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date.
Pathbase: Pathology Committee
Benign proliferation of the basal layer cells of the skin.
George Gkoutos
mouse_pathology.ontology
MPATH:152
basal cell hyperplasia
Benign proliferation of the basal layer cells of the skin.
Pathbase: Curation
Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis.
George Gkoutos
mouse_pathology.ontology
MPATH:153
hypergranulosis
Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis.
Pathbase: Pathology Committee
Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis.
George Gkoutos
mouse_pathology.ontology
cornification
hyperorthokeratosis
hyperparakeratosis
MPATH:154
hyperkeratosis
Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis.
Pathbase: Pathology Committee
cornification
Pathbase: Curation
hyperorthokeratosis
Pathbase: Curation
hyperparakeratosis
Pathbase: Curation
Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium.
George Gkoutos
mouse_pathology.ontology
MPATH:155
orthokeratosis
Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium.
Pathbase: Pathology Committee
Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum.
George Gkoutos
mouse_pathology.ontology
MPATH:156
parakeratosis
Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum.
Pathbase: Pathology Committee
Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma.
George Gkoutos
mouse_pathology.ontology
pseudocarcinoma
pseudocarcinomatous hyperplasia
pseudoepitheliomatous hyperplasia
MPATH:157
pseudoepithelioma/pseudocarcinoma
Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma.
ISBN:0781727286
pseudocarcinoma
Pathbase: Curation
pseudocarcinomatous hyperplasia
Pathbase: Curation
pseudoepitheliomatous hyperplasia
Pathbase: Curation
Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts.
George Gkoutos
mouse_pathology.ontology
Basal cell papilloma
seborrheic verruca
MPATH:158
seborrheic keratosis
Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts.
ISBN:0781727286
Basal cell papilloma
Pathbase: Curation
seborrheic verruca
Pathbase: Curation
Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133.
George Gkoutos
mouse_pathology.ontology
MPATH:159
hypertrophy
Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133.
Pathbase: Pathology Committee
A conversion of the connective tissues into a gelatinous or mucous substance.
George Gkoutos
mouse_pathology.ontology
Mucoid degeneration
myxomatosis
MPATH:16
myxoid/myxomatous degeneration
Mucoid degeneration
Pathbase: Curation
myxomatosis
Pathbase: Curation
A conversion of the connective tissues into a gelatinous or mucous substance.
ISBN:0781727286
Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced.
George Gkoutos
mouse_pathology.ontology
MPATH:160
metaplasia
Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced.
Pathbase: Pathology Committee
Metaplasia resulting in heterotopic formation of cartilage.
George Gkoutos
mouse_pathology.ontology
MPATH:161
cartilaginous metaplasia
Metaplasia resulting in heterotopic formation of cartilage.
ISBN:0781727286
Metaplasia occurring within epithelia.
George Gkoutos
mouse_pathology.ontology
MPATH:162
epithelial metaplasia
Metaplasia occurring within epithelia.
ISBN:0781727286
Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands.
George Gkoutos
mouse_pathology.ontology
MPATH:163
apocrine metaplasia
Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands.
ISBN:0781727286
Appearance of heterotopic gastric epithelium.
George Gkoutos
mouse_pathology.ontology
MPATH:164
gastric metaplasia
Appearance of heterotopic gastric epithelium.
ISBN:0781727286
Development of heterotopic glandular epithelia.
George Gkoutos
mouse_pathology.ontology
MPATH:165
glandular metaplasia
Development of heterotopic glandular epithelia.
ISBN:0781727286
Metaplasia resulting in formation of mucus secreting goblet cells.
George Gkoutos
mouse_pathology.ontology
MPATH:166
goblet cell metaplasia
Metaplasia resulting in formation of mucus secreting goblet cells.
ISBN:0781727286
Appearance of heterotopic intestinal epithelium.
George Gkoutos
mouse_pathology.ontology
MPATH:167
intestinal metaplasia
Appearance of heterotopic intestinal epithelium.
ISBN:0781727286
Metaplasia resulting in formation of fat cells.
George Gkoutos
mouse_pathology.ontology
MPATH:168
lipomatous metaplasia
Metaplasia resulting in formation of fat cells.
ISBN:0781727286
.A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron.
George Gkoutos
mouse_pathology.ontology
nephrogenic adenoma
MPATH:169
nephrogenic metaplasia
.A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron.
ISBN:0781727286
nephrogenic adenoma
Pathbase: Curation
Defect of a subcellular structure or organelle.
George Gkoutos
mouse_pathology.ontology
MPATH:17
subcellular defect
Defect of a subcellular structure or organelle.
Pathbase: Pathology Committee
Appearance of oncocytic cells in for example an epithelium or tumor.
George Gkoutos
mouse_pathology.ontology
MPATH:170
An oncocyte is an acidophilic cell containing numerous mitochondria - an oxophil cell.
oncocytic metaplasia
Appearance of oncocytic cells in for example an epithelium or tumor.
ISBN:0781727286
Change of a glandular or mucosal epithelium into squamous epithelium.
George Gkoutos
mouse_pathology.ontology
MPATH:171
squamous metaplasia
Change of a glandular or mucosal epithelium into squamous epithelium.
ISBN:0781727286
Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example.
George Gkoutos
mouse_pathology.ontology
MPATH:172
transitional cell metaplasia
Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example.
ISBN:0781727286
A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow.
George Gkoutos
mouse_pathology.ontology
MPATH:173
myeloid metaplasia
A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow.
ISBN:0781727286
Metaplasia resulting in formation of bone.
George Gkoutos
ectopic bone
mouse_pathology.ontology
MPATH:174
osseous metaplasia
Metaplasia resulting in formation of bone.
ISBN:0781727286
The process, normal or abnormal, of damage repair or wound closure.
George Gkoutos
mouse_pathology.ontology
MPATH:175
healing and repair process
The process, normal or abnormal, of damage repair or wound closure.
Pathbase: Pathology Committee
Replacement of connective tissue by fibro-fatty deposits and scar tissue.
George Gkoutos
mouse_pathology.ontology
MPATH:176
connective tissue replacement
Replacement of connective tissue by fibro-fatty deposits and scar tissue.
Pathbase: Curation
Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis.
George Gkoutos
mouse_pathology.ontology
neovascularisation
MPATH:177
angiogenesis
Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis.
Pathbase: Curation
Abnormal deposition of extracellular matrix proteins or other components.
George Gkoutos
mouse_pathology.ontology
MPATH:178
extracellular matrix deposition
Abnormal deposition of extracellular matrix proteins or other components.
Pathbase: Curation
Deposition of fibrin.
George Gkoutos
mouse_pathology.ontology
MPATH:179
fibrin deposition
Deposition of fibrin.
Pathbase: Curation
Defect in the structure or function of the cytoskeleton.
George Gkoutos
mouse_pathology.ontology
MPATH:18
cytoskeletal defect
Defect in the structure or function of the cytoskeleton.
Pathbase: Pathology Committee
Abnormal or reactive proliferation of fibroblasts.
George Gkoutos
mouse_pathology.ontology
MPATH:180
fibroblast proliferation
Abnormal or reactive proliferation of fibroblasts.
Pathbase: Curation
Reactive formation of fibrous tissue.
George Gkoutos
mouse_pathology.ontology
MPATH:181
fibrosis
Reactive formation of fibrous tissue.
Pathbase: Curation
Proliferation of astrocytes in an area of damage in the brain or spinal cord.
George Gkoutos
mouse_pathology.ontology
MPATH:182
gliosis
Proliferation of astrocytes in an area of damage in the brain or spinal cord.
Pathbase: Curation
Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells.
George Gkoutos
mouse_pathology.ontology
MPATH:183
granulation tissue
Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells.
Pathbase: Pathology Committee
Any pathological thickening or hardening of a tissue.
George Gkoutos
mouse_pathology.ontology
Induration
MPATH:184
sclerosis
Any pathological thickening or hardening of a tissue.
Pathbase: Curation
Induration
Pathbase: Curation
Post-injury regeneration of the functional tissue parenchyma. Eg. Liver.
George Gkoutos
mouse_pathology.ontology
MPATH:185
parenchymal regeneration
Post-injury regeneration of the functional tissue parenchyma. Eg. Liver.
Pathbase: Curation
Complete healing through parenchymal regeneration - no fibrosis.
George Gkoutos
mouse_pathology.ontology
MPATH:186
complete parenchymal regeneration
Complete healing through parenchymal regeneration - no fibrosis.
Pathbase: Curation
Incomplete healing usually accompanied by fibrosis.
George Gkoutos
mouse_pathology.ontology
MPATH:187
incomplete parenchymal regeneration
Incomplete healing usually accompanied by fibrosis.
Pathbase: Pathology Committee
Inappropriate or aberrant activation or suppression of the immune or inflammatory response.
George Gkoutos
mouse_pathology.ontology
MPATH:188
immunopathological process
Inappropriate or aberrant activation or suppression of the immune or inflammatory response.
Pathbase: Pathology Committee
Immune response resulting in tissue injury.
George Gkoutos
mouse_pathology.ontology
MPATH:189
hypersensitivity disease
Immune response resulting in tissue injury.
Pathbase: Curation
Defect in the structure or function of the endoplasmic reticulum.
George Gkoutos
mouse_pathology.ontology
MPATH:19
endoplasmic reticulum defect
Defect in the structure or function of the endoplasmic reticulum.
Pathbase: Pathology Committee
This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks.
George Gkoutos
mouse_pathology.ontology
MPATH:190
type I hypersensitivity
This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks.
ISBN:0781727286
Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues.
George Gkoutos
mouse_pathology.ontology
MPATH:191
Most often involves IgG and IgM. Complement activation is usually involved.
type II hypersensitivity
Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues.
ISBN:0781727286
Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury.
George Gkoutos
mouse_pathology.ontology
MPATH:192
type III hypersensitivity
Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury.
ISBN:0781727286
An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact.
George Gkoutos
mouse_pathology.ontology
MPATH:193
type IV hypersensitivity
An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact.
ISBN:0781727286
Tissue response to inappropriate immune/inflammatory process.
George Gkoutos
mouse_pathology.ontology
MPATH:194
immune mediated disease
Tissue response to inappropriate immune/inflammatory process.
Pathbase: Curation
Inflammation of a joint.
George Gkoutos
mouse_pathology.ontology
MPATH:195
arthritis
Inflammation of a joint.
Pathbase: Curation
Inflammation of the skin.
George Gkoutos
mouse_pathology.ontology
MPATH:196
dermatitis
Inflammation of the skin.
Pathbase: Curation
Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment.
George Gkoutos
mouse_pathology.ontology
MPATH:197
glomerulonephritis
Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment.
Pathbase: Curation
An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction.
George Gkoutos
mouse_pathology.ontology
MPATH:198
immune mediated hemolytic anaemia
An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction.
ISBN:0781727286
A condition resulting from an increased rate of immune mediated platelet destruction.
George Gkoutos
mouse_pathology.ontology
MPATH:199
immune mediated thrombocytopenia
A condition resulting from an increased rate of immune mediated platelet destruction.
ISBN:0781727286
Complete and irreversible cessation of metabolic activity.
George Gkoutos
mouse_pathology.ontology
MPATH:2
cell death
Complete and irreversible cessation of metabolic activity.
Pathbase: Pathology Committee
Defect in the structure or function of the golgi apparatus.
George Gkoutos
mouse_pathology.ontology
MPATH:20
golgi defect
Defect in the structure or function of the golgi apparatus.
Pathbase: Pathology Committee
Inflammation of a muscle.
George Gkoutos
mouse_pathology.ontology
Initis
MPATH:200
myositis
Inflammation of a muscle.
Pathbase: Curation
Initis
Pathbase: Curation
Inflammation of a blood vessel.
George Gkoutos
mouse_pathology.ontology
angiitis
arteritis
lymphangiitis
phlebitis
MPATH:201
vasculitis
Inflammation of a blood vessel.
Pathbase: Pathology Committee
angiitis
Pathbase: Curation
arteritis
Pathbase: Curation
lymphangiitis
Pathbase: Curation
phlebitis
Pathbase: Curation
Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease.
George Gkoutos
mouse_pathology.ontology
MPATH:202
immunodeficiency disease
Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease.
Pathbase: Curation
general immunodeficiency disease
mouse_pathology.ontology
MPATH:203
obsolete. Subsumed into MPATH:202
general immunodeficiency disease
true
general immunodeficiency disease
Pathbase: Curation
chronic/recurrent inflammatory disease
mouse_pathology.ontology
MPATH:204
obsolete. Subsumed into MPATH: 214.
chronic/recurrent inflammatory disease
true
chronic/recurrent inflammatory disease
Pathbase: Curation
Infection with bacteria, viruses or fungi subsequent to immunodeficiency.
mouse_pathology.ontology
MPATH:205
immunodeficiency associated infection
true
Infection with bacteria, viruses or fungi subsequent to immunodeficiency.
Pathbase: Pathology Committee
Disease due to primary molecular or cellular defect in the immune system or its development.
George Gkoutos
mouse_pathology.ontology
MPATH:206
primary immunodeficiency disease
Disease due to primary molecular or cellular defect in the immune system or its development.
Pathbase: Curation
Primary defect in the lymphoid arm of the immune system.
George Gkoutos
mouse_pathology.ontology
MPATH:207
immunodeficiency - lymphoid defect
Primary defect in the lymphoid arm of the immune system.
Pathbase: Curation
Primary defect in the myeloid arm of the immune system.
George Gkoutos
mouse_pathology.ontology
MPATH:208
immunodeficiency - myeloid/phagocytic defect
Primary defect in the myeloid arm of the immune system.
Pathbase: Curation
Defect in the immune system subsequent to external injury, infection, ablation or deficiency.
George Gkoutos
mouse_pathology.ontology
MPATH:209
secondary immunodeficiency disease
Defect in the immune system subsequent to external injury, infection, ablation or deficiency.
Pathbase: Curation
Defect in the structure or function of the lysosomes.
George Gkoutos
mouse_pathology.ontology
MPATH:21
lysosomal defect
Defect in the structure or function of the lysosomes.
Pathbase: Curation
Defect in the immune system subsequent to external injury, infection or ablation.
George Gkoutos
mouse_pathology.ontology
MPATH:210
acquired immunodeficiency
Defect in the immune system subsequent to external injury, infection or ablation.
Pathbase: Curation
Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins.
George Gkoutos
mouse_pathology.ontology
MPATH:211
failed transfer of maternal immunoglobulin
Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins.
Pathbase: Pathology Committee
A tissue reaction to an internal or external injury.
George Gkoutos
mouse_pathology.ontology
MPATH:212
inflammation
A tissue reaction to an internal or external injury.
Pathbase: Pathology Committee
Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia.
George Gkoutos
mouse_pathology.ontology
MPATH:213
The five classical signs of inflammation: Rubor, tumor, calor, dolor, functio laesa (Galen 300BC).
acute inflammation
Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia.
Pathbase: Pathology Committee
Chronic inflammatory condition characterised by infiltration of primarily lymphocytes.
George Gkoutos
mouse_pathology.ontology
MPATH:214
chronic inflammation
Chronic inflammatory condition characterised by infiltration of primarily lymphocytes.
Pathbase: Pathology Committee
Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma.
George Gkoutos
mouse_pathology.ontology
MPATH:215
granulomatous inflammation
Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma.
ISBN:0781727286
Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue.
George Gkoutos
mouse_pathology.ontology
MPATH:216
necrotic inflammation
Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue.
ISBN:0781727286
Combination of inflammation, often suppurative or granulomatous, with ulceration.
mouse_pathology.ontology
MPATH:217
Ulcers may be a component or inflammation. Use MPATH: Ulcer
ulcerative inflammation
true
Combination of inflammation, often suppurative or granulomatous, with ulceration.
ISBN:0781727286
A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant.
George Gkoutos
mouse_pathology.ontology
MPATH:218
neoplasm
A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant.
Pathbase: Pathology Committee
Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures.
George Gkoutos
mouse_pathology.ontology
MPATH:219
adnexal and skin appendage tumor
Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures.
Pathbase: Curation
Defect in the structure or function of the mitochondria.
George Gkoutos
mouse_pathology.ontology
MPATH:22
mitochondrial defect
Defect in the structure or function of the mitochondria.
Pathbase: Curation
Carcinoma of the glandular epithelium of apocrine glands (M-8401/3).
George Gkoutos
mouse_pathology.ontology
MPATH:220
apocrine adenocarcinoma
Carcinoma of the glandular epithelium of apocrine glands (M-8401/3).
Pathbase: Pathology Committee
Benign neoplasm of the epithelium of apocrine glands (M-8401/0).
George Gkoutos
mouse_pathology.ontology
MPATH:221
apocrine adenoma
Benign neoplasm of the epithelium of apocrine glands (M-8401/0).
Pathbase: Curation
Malignant carcinoma of the ceruminous gland (M-8420/3).
George Gkoutos
mouse_pathology.ontology
MPATH:222
ceruminous adenocarcinoma
Malignant carcinoma of the ceruminous gland (M-8420/3).
Pathbase: Curation
Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0).
mouse_pathology.ontology
MPATH:223
ceruminous adenoma
Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0).
Pathbase: Curation
Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 ).
mouse_pathology.ontology
Eccrine acrospiroma
nodular hidradenoma
MPATH:224
clear cell hidradenoma
Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 ).
Pathbase: Curation
Eccrine acrospiroma
Pathbase: Curation
nodular hidradenoma
Pathbase: Curation
Malignant neoplasm of the eccrine gland (M-8413/3).
mouse_pathology.ontology
MPATH:225
eccrine gland adenocarcinoma
Malignant neoplasm of the eccrine gland (M-8413/3).
Pathbase: Curation
Benign neoplasm of the eccrine gland (M-8408/0).
mouse_pathology.ontology
MPATH:226
eccrine gland adenoma
Benign neoplasm of the eccrine gland (M-8408/0).
:Papillary adenoma
Papillary form of eccrine sweat gland adenoma. (M -8408/0).
mouse_pathology.ontology
Papillary adenoma
benign neoplasm of the eccrine gland, papillary form
MPATH:227
eccrine papillary adenoma
Papillary form of eccrine sweat gland adenoma. (M -8408/0).
Pathbase: Pathology Committee
Papillary adenoma
Pathbase: Curation
benign neoplasm of the eccrine gland, papillary form
Pathbase: Curation
Benign apocrine sweat gland tumor (8405/0).
mouse_pathology.ontology
Hidradenoma papilliferum
MPATH:228
papillary hidradenoma
Benign apocrine sweat gland tumor (8405/0).
Pathbase: Curation
Hidradenoma papilliferum
Pathbase: Curation
Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3).
mouse_pathology.ontology
sebaceous carcinoma
MPATH:229
sebaceous adenocarcinoma
Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3).
Pathbase: Curation
sebaceous carcinoma
Pathbase: Curation
Defect in the structure or function of the peroxysomes.
mouse_pathology.ontology
MPATH:23
peroxysomal defect
Defect in the structure or function of the peroxysomes.
Pathbase: Curation
Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0).
mouse_pathology.ontology
Epithelioma
MPATH:230
sebaceous adenoma
Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0).
Pathbase: Curation
Epithelioma
Pathbase: Curation
A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0).
mouse_pathology.ontology
MPATH:231
syringoma
A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0).
Pathbase: Curation
Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0).
mouse_pathology.ontology
Epithelioma adenoides cysticum
benign
hair follicle tumor
MPATH:232
trichoepithelioma
Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0).
URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models
Epithelioma adenoides cysticum
Pathbase: Curation
benign
Pathbase: Curation
hair follicle tumor
Pathbase: Curation
Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0).
mouse_pathology.ontology
Benign basal cell tumor
basal cell adenoma
MPATH:233
basal cell tumor
Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0).
Pathbase: Pathology Committee
Benign basal cell tumor
Pathbase: Curation
basal cell adenoma
Pathbase: Curation
Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3).
mouse_pathology.ontology
MPATH:234
basal cell carcinoma
Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3).
URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models
Tumor of venous or arterial vessels or capillaries.
mouse_pathology.ontology
MPATH:235
blood vessel tumor
Tumor of venous or arterial vessels or capillaries.
Pathbase: Pathology Committee
.A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0).
mouse_pathology.ontology
Telangiectatic fibroma
MPATH:236
angiofibroma
.A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0).
Pathbase: Curation
Telangiectatic fibroma
Pathbase: Curation
An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0).
mouse_pathology.ontology
keratoangioma
telangiectasia verrucosa
telangiectatic wart
MPATH:237
angiokeratoma
An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0).
Pathbase: Curation
keratoangioma
Pathbase: Curation
telangiectasia verrucosa
Pathbase: Curation
telangiectatic wart
Pathbase: Curation
A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1).
mouse_pathology.ontology
Angioblastoma
MPATH:238
hemangioblastoma
A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1).
Pathbase: Pathology Committee
Angioblastoma
Pathbase: Curation
hemangioendothelioma
mouse_pathology.ontology
MPATH:239
obsolete Use Hemangioma MPATH: 240
hemangioendothelioma
true
hemangioendothelioma
Pathbase: Curation
Defect in the structure or function of the plasma membrane.
mouse_pathology.ontology
MPATH:24
plasma membrane defect
Defect in the structure or function of the plasma membrane.
Pathbase: Curation
Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively).
mouse_pathology.ontology
Angioendothelioma.
Hemangioendothelioma, benign
MPATH:240
hemangioma
Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively).
PMID:8569146
Angioendothelioma.
Pathbase: Curation
Hemangioendothelioma, benign
Pathbase: Curation
A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3).
mouse_pathology.ontology
Pericytoma
MPATH:241
hemangiopericytoma
A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3).
Pathbase: Pathology Committee
Pericytoma
Pathbase: Curation
Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3).
mouse_pathology.ontology
Hemangioma malignant
hemangioendothelioma malignant, angiosarcoma
hemangioendothelioma malignant.
MPATH:242
hemangiosarcoma
Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3).
PMID:8569146
Hemangioma malignant
Pathbase: Curation
hemangioendothelioma malignant, angiosarcoma
Pathbase: Curation
hemangioendothelioma malignant.
Pathbase: Curation
Neoplasm of the neurones, glia or meninges of the CNS.
mouse_pathology.ontology
MPATH:243
central nervous system tumor
Neoplasm of the neurones, glia or meninges of the CNS.
Pathbase: Curation
Glioma derived from astrocytes, both benign and malignant forms (M-9400/3).
mouse_pathology.ontology
Astrocytic glioma
astroglioma
MPATH:244
Also see comments in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
astrocytoma
Glioma derived from astrocytes, both benign and malignant forms (M-9400/3).
ISBN-13:9783794515530
Astrocytic glioma
Pathbase: Curation
astroglioma
Pathbase: Curation
Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3).
mouse_pathology.ontology
MPATH:245
choroid plexus carcinoma
Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3).
ISBN-13:9783794515530
Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0).
mouse_pathology.ontology
MPATH:246
choroid plexus papilloma
Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0).
ISBN-13:9783794515530
Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3).
mouse_pathology.ontology
MPATH:247
Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
ependymoma
Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3).
ISBN-13:9783794515530
ependymoma malignant
mouse_pathology.ontology
MPATH:248
obsolete -subsumed into MPATH:247
ependymoma malignant
true
ependymoma malignant
Pathbase: Curation
Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3).
mouse_pathology.ontology
MPATH:249
Also see comments in: Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
glioma
Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3).
ISBN-13:9783794515530
Degenerative process characteristic of a particular tissue.
mouse_pathology.ontology
MPATH:25
tissue specific degenerative process
Degenerative process characteristic of a particular tissue.
Pathbase: Curation
Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS.
mouse_pathology.ontology
MPATH:250
Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
medulloblastoma
Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS.
ISBN-13:9783794515530
meningioma
mouse_pathology.ontology
Sarcoma, meningeal ( sensu malignant tumor)
MPATH:251
Benign or malignant neoplasm derived from the meninges. (M-9530/0).
meningioma
meningioma
ISBN-13:9783794515530
Sarcoma, meningeal ( sensu malignant tumor)
Pathbase: Curation
Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3).
mouse_pathology.ontology
Glioma, oligodendritic, benign
glioma oligodendritic, malignant
MPATH:252
Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
oligodendroglioma
Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3).
ISBN-13:9783794515530
Glioma, oligodendritic, benign
Pathbase: Curation
glioma oligodendritic, malignant
Pathbase: Curation
Neoplasm derived from sub-ependymal astrocytes (M-9383/1).
mouse_pathology.ontology
MPATH:253
Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
sub-ependymoma
Neoplasm derived from sub-ependymal astrocytes (M-9383/1).
ISBN-13:9783794515530
Tumors showing multiple histological componants/differentiation.
mouse_pathology.ontology
MPATH:254
complex tumor
Tumors showing multiple histological componants/differentiation.
Pathbase: Pathology Committee
Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3).
mouse_pathology.ontology
adenoid squamous cell carcinoma
MPATH:255
adenoacanthoma
Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3).
Pathbase: Curation
adenoid squamous cell carcinoma
Pathbase: Curation
Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3).
mouse_pathology.ontology
MPATH:256
carcinosarcoma
Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3).
Pathbase: Curation
A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1).
mouse_pathology.ontology
Erdheim tumor
Pituitary adamantinoma
Rathke pouch tumor
pituitary ameloblastoma
suprasellar cyst
MPATH:257
craniopharyngioma
A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1).
Pathbase: Pathology Committee
Erdheim tumor
Pathbase: Curation
Pituitary adamantinoma
Pathbase: Curation
Rathke pouch tumor
Pathbase: Curation
pituitary ameloblastoma
Pathbase: Curation
suprasellar cyst
Pathbase: Curation
Neoplasm showing multiple phases, derived from mesoderm (M-8951/3).
mouse_pathology.ontology
MPATH:258
mesodermal mixed tumor
Neoplasm showing multiple phases, derived from mesoderm (M-8951/3).
Pathbase: Curation
Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3).
mouse_pathology.ontology
MPATH:259
mucoepidermoid carcinoma
Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3).
Pathbase: Curation
Absence of hair or loss of hair.
mouse_pathology.ontology
MPATH:26
alopecia
Absence of hair or loss of hair.
ISBN:0781727286
Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3).
mouse_pathology.ontology
MPATH:260
mullerian mixed tumor
Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3).
Pathbase: Pathology Committee
Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3).
mouse_pathology.ontology
nephroma
MPATH:261
nephroblastoma
Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3).
Pathbase: Pathology Committee
nephroma
Pathbase: Curation
A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3).
mouse_pathology.ontology
MPATH:262
pulmonary blastoma
A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3).
Pathbase: Pathology Committee
Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3.
mouse_pathology.ontology
Malignant rhabdoid tumor
MPATH:263
rhabdoid sarcoma
Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3.
Pathbase: Curation
Malignant rhabdoid tumor
Pathbase: Curation
Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030).
mouse_pathology.ontology
MPATH:264
fibroepithelial tumor
Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030).
Pathbase: Curation
A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0).
mouse_pathology.ontology
Cystadenofibroma
papillary adenofibroma
MPATH:265
adenofibroma
A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0).
Pathbase: Curation
Cystadenofibroma
Pathbase: Curation
papillary adenofibroma
Pathbase: Curation
A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0).
mouse_pathology.ontology
MPATH:266
fibroadenoma
A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0).
Pathbase: Curation
Neoplasms derived from glandular epithelial cells.
mouse_pathology.ontology
MPATH:267
glandular tumor
Neoplasms derived from glandular epithelial cells.
Pathbase: Curation
Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3).
mouse_pathology.ontology
MPATH:268
adenocarcinoma
Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3).
Pathbase: Curation
A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2).
mouse_pathology.ontology
MPATH:269
adenocarcinoma in situ
A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2).
Pathbase: Pathology Committee
Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process.
mouse_pathology.ontology
Degenerative joint disease
osteoarthrosis
MPATH:27
arthrosis
Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process.
ISBN:0781727286
Degenerative joint disease
Pathbase: Curation
osteoarthrosis
Pathbase: Curation
A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy.
mouse_pathology.ontology
MPATH:270
adenoma
A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy.
Pathbase: Pathology Committee
Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0).
mouse_pathology.ontology
MPATH:271
adenomatous polyposis coli
Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0).
Pathbase: Curation
Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification.
URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
mouse_pathology.ontology
Bronchial adenoma
Bronchial adenoma, BA adenoma
MPATH:272
bronchioloalveolar adenoma
Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification.
PMID:15059877
Bronchial adenoma
Pathbase: Curation
Bronchial adenoma, BA adenoma
Pathbase: Curation
Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification.
URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
mouse_pathology.ontology
Bronchioloalveolar adenocarcinoma
Bronchioloalveolar adenocarcinoma, bronchioalveolar carcinoma
MPATH:273
bronchioloalveolar carcinoma
Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification.
PMID:15059877
Bronchioloalveolar adenocarcinoma
Pathbase: Curation
Bronchioloalveolar adenocarcinoma, bronchioalveolar carcinoma
Pathbase: Curation
An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3).
mouse_pathology.ontology
MPATH:274
clear cell adenocarcinoma
An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3).
Pathbase: Curation
Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3).
mouse_pathology.ontology
MPATH:275
comedocarcinoma
Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3).
Pathbase: Pathology Committee
Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3).
mouse_pathology.ontology
MPATH:276
cystadenocarcinoma
Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3).
Pathbase: Curation
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0).
mouse_pathology.ontology
MPATH:277
cystadenoma
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0).
Pathbase: Pathology Committee
Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3).
mouse_pathology.ontology
Follicular carcinoma
MPATH:278
follicular adenocarcinoma
Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3).
Pathbase: Curation
Follicular carcinoma
Pathbase: Curation
Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0.
mouse_pathology.ontology
MPATH:279
follicular adenoma
Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0.
Pathbase: Curation
Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification.
mouse_pathology.ontology
MPATH:28
Note that in mouse and rats the initial lesions are mostly in the medial layer while in human they occur in the intima.
atherosclerosis
Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification.
Pathbase: Pathology Committee
Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms.
mouse_pathology.ontology
MPATH:280
Harderian gland adenoma
Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms.
Pathbase: Pathology Committee
Malignant tumor derived form acinar epithelium of the Harderian gland.
mouse_pathology.ontology
MPATH:281
Harderian gland carcinoma
Malignant tumor derived form acinar epithelium of the Harderian gland.
Pathbase: Pathology Committee
Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3).
mouse_pathology.ontology
Infiltrating ductal adenocarcinoma
duct adenocarcinoma
ductal carcinoma
MPATH:282
infiltrating duct carcinoma
Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3).
Pathbase: Pathology Committee
Infiltrating ductal adenocarcinoma
Pathbase: Curation
duct adenocarcinoma
Pathbase: Curation
ductal carcinoma
Pathbase: Curation
In situ carcinoma of the mammary ductal epithelium. (M- 8500/2).
mouse_pathology.ontology
Ductal carcinoma in situ
intraductal adenocarcinoma, non-infiltrating
MPATH:283
Made obsolete by inclusion in MPATH: 486 Ductal intra-epithelial neoplasia
intraductal carcinoma
true
In situ carcinoma of the mammary ductal epithelium. (M- 8500/2).
Pathbase: Curation
Ductal carcinoma in situ
Pathbase: Curation
intraductal adenocarcinoma, non-infiltrating
Pathbase: Curation
Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3).
mouse_pathology.ontology
Intraductal papillary adenocarcinoma
MPATH:284
intraductal papillary carcinoma
Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3).
Pathbase: Curation
Intraductal papillary adenocarcinoma
Pathbase: Curation
Benign papilloma arising from ductal epithelium (M- 8503/0 ).
mouse_pathology.ontology
Duct adenoma
ductal papilloma
MPATH:285
intraductal papilloma
Benign papilloma arising from ductal epithelium (M- 8503/0 ).
Pathbase: Curation
Duct adenoma
Pathbase: Curation
ductal papilloma
Pathbase: Curation
Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0).
mouse_pathology.ontology
Diffuse intraductal papillomatosis
MPATH:286
intraductal papillomatosis
Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0).
Pathbase: Curation
Diffuse intraductal papillomatosis
Pathbase: Curation
Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0).
mouse_pathology.ontology
Adenoma, endocrine pancreas
adenomatosis
islet (pancreatic) cell tumor benign
MPATH:287
islet cell adenoma
Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0).
Pathbase: Curation
Adenoma, endocrine pancreas
Pathbase: Curation
adenomatosis
Pathbase: Curation
islet (pancreatic) cell tumor benign
Pathbase: Curation
Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3).
mouse_pathology.ontology
Adenocarcinoma, endocrine pancreas
islet cell tumor, malignant
MPATH:288
islet cell carcinoma
Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3).
Pathbase: Pathology Committee
Adenocarcinoma, endocrine pancreas
Pathbase: Curation
islet cell tumor, malignant
Pathbase: Curation
A form of breast adenocarcinoma derived from lobular cells. (M-8520/3).
mouse_pathology.ontology
Lobular adenocarcinoma
lobular infiltrating carcinoma
MPATH:289
lobular carcinoma
A form of breast adenocarcinoma derived from lobular cells. (M-8520/3).
Pathbase: Curation
Lobular adenocarcinoma
Pathbase: Curation
lobular infiltrating carcinoma
Pathbase: Curation
Opacity of the lens.
mouse_pathology.ontology
MPATH:29
cataract
Opacity of the lens.
PMID:9309781
Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2).
mouse_pathology.ontology
mammary intra-epithelial neoplasia
MPATH:290
lobular carcinoma in situ
Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2).
ISBN:0781727286
mammary intra-epithelial neoplasia
Pathbase: Curation
Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3).
mouse_pathology.ontology
Medullary adenocarcinoma
MPATH:291
medullary carcinoma
Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3).
Pathbase: Pathology Committee
Medullary adenocarcinoma
Pathbase: Curation
Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3).
mouse_pathology.ontology
MPATH:292
mucinous cystadenocarcinoma
Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3).
Pathbase: Pathology Committee
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0).
mouse_pathology.ontology
MPATH:293
mucinous cystadenoma
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0).
Pathbase: Pathology Committee
Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0).
mouse_pathology.ontology
myoepithelial adenoma
MPATH:294
myoepithelioma
Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0).
Pathbase: Pathology Committee
myoepithelial adenoma
Pathbase: Curation
A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3).
mouse_pathology.ontology
MPATH:295
papillary adenocarcinoma
A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3).
Pathbase: Pathology Committee
A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0).
mouse_pathology.ontology
MPATH:296
papillary adenoma
A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0).
Pathbase: Pathology Committee
A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3).
mouse_pathology.ontology
MPATH:297
papillary cystadenocarcinoma
A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3).
Pathbase: Pathology Committee
A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0).
mouse_pathology.ontology
MPATH:298
papillary cystadenoma
A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0).
Pathbase: Pathology Committee
Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1).
mouse_pathology.ontology
MPATH:299
pinealoma
Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1).
Pathbase: Pathology Committee
Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies.
mouse_pathology.ontology
programmed cell death
MPATH:3
apoptosis
Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies.
Pathbase: Pathology Committee
programmed cell death
Pathbase: Curation
Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide.
mouse_pathology.ontology
Erdheim disease
Mucoid medial degeneration
media necrosis aortae idiopathica cystica
media necrosis of the aorta
MPATH:30
cystic medial necrosis
Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide.
ISBN:0781727286
Erdheim disease
Pathbase: Curation
Mucoid medial degeneration
Pathbase: Curation
media necrosis aortae idiopathica cystica
Pathbase: Curation
media necrosis of the aorta
Pathbase: Curation
Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3).
mouse_pathology.ontology
Mixed pineal tumor
pineal parenchymal tumor of intermediate differentiation
transitional pineal tumor
MPATH:300
pineoblastoma
Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3).
Pathbase: Pathology Committee
Mixed pineal tumor
Pathbase: Curation
pineal parenchymal tumor of intermediate differentiation
Pathbase: Curation
transitional pineal tumor
Pathbase: Curation
A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1).
mouse_pathology.ontology
MPATH:301
pineocytoma
A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1).
Pathbase: Curation
Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0).
mouse_pathology.ontology
pituitary adenoma
MPATH:302
pituicytoma
Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0).
Pathbase: Curation
pituitary adenoma
Pathbase: Curation
Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6).
mouse_pathology.ontology
MPATH:303
pseudomyxoma peritonei
Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6).
Pathbase: Curation
Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3).
mouse_pathology.ontology
MPATH:304
serous adenocarcinoma
Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3).
Pathbase: Pathology Committee
Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0).
mouse_pathology.ontology
MPATH:305
serous cystadenoma
Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0).
Pathbase: Curation
Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3).
mouse_pathology.ontology
Signet ring cell adenocarcinoma
signet ring cell carcinoma
MPATH:306
signet ring cell carcinoma
Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3).
PMID:12612914
Signet ring cell adenocarcinoma
Pathbase: Curation
signet ring cell carcinoma
Pathbase: Curation
Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland.
mouse_pathology.ontology
Adenoma, parafollicular cell
tumor c-cell benign
MPATH:307
thyroid C-cell adenoma
Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland.
Pathbase: Curation
Adenoma, parafollicular cell
Pathbase: Curation
tumor c-cell benign
Pathbase: Curation
Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3).
mouse_pathology.ontology
Medullary carcinoma, parafollicular cell
tumor c-cell malignant
MPATH:308
thyroid C-cell carcinoma
Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3).
Pathbase: Curation
Medullary carcinoma, parafollicular cell
Pathbase: Curation
tumor c-cell malignant
Pathbase: Curation
Germ cell and non-germ cell tumors of the testis and ovary.
mouse_pathology.ontology
MPATH:309
gonadal tumor
Germ cell and non-germ cell tumors of the testis and ovary.
Pathbase: Pathology Committee
Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number.
mouse_pathology.ontology
MPATH:31
emphysema
Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number.
ISBN:0781727286
Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells.
mouse_pathology.ontology
MPATH:310
germ cell tumor
Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells.
Pathbase: Pathology Committee
Cystic ovarian teratomas with different mature cell types (M-9084/3).
mouse_pathology.ontology
MPATH:311
dermoid cyst
Cystic ovarian teratomas with different mature cell types (M-9084/3).
Pathbase: Curation
Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3).
mouse_pathology.ontology
Seminoma (sensu male)
MPATH:312
dysgerminoma
Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3).
Pathbase: Curation
Seminoma (sensu male)
Pathbase: Curation
Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 ).
mouse_pathology.ontology
MPATH:313
embryonal carcinoma
Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 ).
Pathbase: Curation
Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3).
mouse_pathology.ontology
Yolk sac carcinoma
MPATH:314
endodermal sinus tumor
Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3).
Pathbase: Pathology Committee
Yolk sac carcinoma
Pathbase: Curation
Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1).
mouse_pathology.ontology
Gonocytoma
MPATH:315
gonadoblastoma
Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1).
Pathbase: Curation
Gonocytoma
Pathbase: Curation
Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3).
mouse_pathology.ontology
Mixed teratoma and seminoma
MPATH:316
mixed germ cell tumor
Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3).
Pathbase: Curation
Mixed teratoma and seminoma
Pathbase: Curation
Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3).
mouse_pathology.ontology
Germinoma, malignant
dysgerminoma
spermatoblastoma
spermatocytoma, malignant.
MPATH:317
seminoma
Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3).
Pathbase: Curation
Germinoma, malignant
Pathbase: Curation
dysgerminoma
Pathbase: Curation
spermatoblastoma
Pathbase: Curation
spermatocytoma, malignant.
Pathbase: Curation
As MPATH:317, but not spermatocytic (M-9061/3).
mouse_pathology.ontology
MPATH:318
classical seminoma
As MPATH:317, but not spermatocytic (M-9061/3).
Pathbase: Curation
Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3).
mouse_pathology.ontology
Spermatoma
MPATH:319
spermatocytic seminoma
Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3).
:Walt; H.; Oosterhuis; J.W. and Stevens; L.C. (1993) Int J Androl; 16; 267-271
Spermatoma
Pathbase: Curation
Increase in the intraocular pressure.
mouse_pathology.ontology
MPATH:32
glaucoma
Increase in the intraocular pressure.
Pathbase: Curation
Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0).
mouse_pathology.ontology
MPATH:320
struma ovarii
Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0).
Pathbase: Curation
Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3).
mouse_pathology.ontology
MPATH:321
teratocarcinoma
Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3).
Pathbase: Curation
Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1).
mouse_pathology.ontology
MPATH:322
teratoma
Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1).
Pathbase: Pathology Committee
Neoplasms derived from the non-germ cell derived tissues of the testis and ovary.
mouse_pathology.ontology
MPATH:323
gonadal somatic cell tumor
Neoplasms derived from the non-germ cell derived tissues of the testis and ovary.
Pathbase: Curation
obsolete use Sertoli cell tumor MPATH: 331.
mouse_pathology.ontology
MPATH:324
androblastoma
true
obsolete use Sertoli cell tumor MPATH: 331.
Pathbase: Curation
obsolete use thecoma MPATH:334.
mouse_pathology.ontology
MPATH:325
fibrothecoma
true
obsolete use thecoma MPATH:334.
Pathbase: Curation
. Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1).
mouse_pathology.ontology
Tumor, sex cord stromal, benign, granulosa cell type
gynoblastoma (sensu malignant form in ovary)
MPATH:326
granulosa cell tumor
. Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1).
PMID:9789961
Tumor, sex cord stromal, benign, granulosa cell type
Pathbase: Curation
gynoblastoma (sensu malignant form in ovary)
Pathbase: Curation
gynandroblastoma
mouse_pathology.ontology
MPATH:327
obsolete Use sertoli-leydig cell tumor MPATH 332
gynandroblastoma
true
gynandroblastoma
Pathbase: Curation
Tumor derived from Leydig cells (M-8650/1).
mouse_pathology.ontology
Interstitial cell tumor, benign
Leydig cell adenoma
MPATH:328
leydig cell tumor
Tumor derived from Leydig cells (M-8650/1).
Mahler M; Sundberg JP ( 1997) Spontaneous Leydig cell tumors in inbred laboratory mice Lab Animal Science 47:148-52
Interstitial cell tumor, benign
Pathbase: Curation
Leydig cell adenoma
Pathbase: Curation
Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0).
mouse_pathology.ontology
Luteoma
luteinised granulosa cell tumor, benign. Gonadal sex cord stromal tumor, benign, luteoma type
MPATH:329
luteal cell tumor
Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0).
Pathbase: Curation
Luteoma
Pathbase: Curation
luteinised granulosa cell tumor, benign. Gonadal sex cord stromal tumor, benign, luteoma type
Pathbase: Curation
Accumulation of substances within, on the surface of or between cells.
mouse_pathology.ontology
MPATH:33
intracellular and extracellular accumulation
Accumulation of substances within, on the surface of or between cells.
Pathbase: Pathology Committee
Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1).
mouse_pathology.ontology
MPATH:330
ovarian stromal tumor
Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1).
Pathbase: Curation
Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1).
mouse_pathology.ontology
Androblastoma
arrhenoblastoma
gonadal stromal tumor
sex cord stromal tumor
sustentacluar tumor
MPATH:331
sertoli cell tumor
Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1).
Pathbase: Pathology Committee
Androblastoma
Pathbase: Curation
arrhenoblastoma
Pathbase: Curation
gonadal stromal tumor
Pathbase: Curation
sex cord stromal tumor
Pathbase: Curation
sustentacluar tumor
Pathbase: Curation
Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0).
mouse_pathology.ontology
Gynandroblastoma
MPATH:332
sertoli-leydig cell tumor
Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0).
Pathbase: Pathology Committee
Gynandroblastoma
Pathbase: Curation
sex cord tumor
mouse_pathology.ontology
MPATH:333
obsolete: Use more specific terms: MPATH: 334, 331, 329, 326
sex cord tumor
true
sex cord tumor
Pathbase: Curation
Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0).
mouse_pathology.ontology
Fibrothecoma
theca cell tumor
MPATH:334
thecoma
Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0).
Pathbase: Curation
Fibrothecoma
Pathbase: Curation
theca cell tumor
Pathbase: Curation
Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages.
mouse_pathology.ontology
MPATH:335
hematopoietic/lymphoid malignancies/disorder
Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
leukaemia
mouse_pathology.ontology
MPATH:336
obsolete folowing reclassification.
leukaemia
true
leukaemia
Pathbase: Curation
Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:337
erythroid leukaemia
Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue.
PMID:12070033
granulocytic leukaemia
mouse_pathology.ontology
MPATH:338
obsolete following reclassification see: MPATH505
granulocytic leukaemia
true
granulocytic leukaemia
Pathbase: Curation
lymphatic leukaemia
mouse_pathology.ontology
MPATH:339
lymphatic leukaemia
true
lymphatic leukaemia
Pathbase: Curation
Extracellular deposition of amyloid protein.
mouse_pathology.ontology
Amyloidosis
MPATH:34
Any group of chemically diverse proteins that appears microscopically homogeneous, but is composed of linear non-branching aggregated fibrils aranged in sheets when see under the electron microscope.
amyloid deposition
Extracellular deposition of amyloid protein.
ISBN:0781727286
Amyloidosis
Pathbase: Curation
Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:340
megakaryocytic leukaemia
Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue.
PMID:12070033
Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:341
myelodysplastic disorder
Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts.
PMID:12070033
Leukaemias of the myeloid lineage.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
granulocytic leukaemia
MPATH:342
myeloid leukaemia
Leukaemias of the myeloid lineage.
PMID:12070033
granulocytic leukaemia
Pathbase: Curation
lymphoma
mouse_pathology.ontology
MPATH:343
obsolete; divided between subtypes of MPATH516, MPATH535
lymphoma
true
lymphoma
Pathbase: Curation
follicle center cell lymphoma
mouse_pathology.ontology
MPATH:344
obsolete; see MPATH 522
follicle center cell lymphoma
true
follicle center cell lymphoma
Pathbase: Curation
immunoblastic lymphoma
mouse_pathology.ontology
MPATH:345
obsolete; see MPATH525
immunoblastic lymphoma
true
immunoblastic lymphoma
Pathbase: Curation
George Gkoutos
2011-03-22T01:12:01Z
mouse_pathology.ontology
MPATH:346
autoimmune mediated disease
small lymphocytic lymphoma
mouse_pathology.ontology
MPATH:347
obsolete; see MPATH520
small lymphocytic lymphoma
true
small lymphocytic lymphoma
Pathbase: Curation
thymic lymphoma
mouse_pathology.ontology
MPATH:348
obsolete
thymic lymphoma
true
thymic lymphoma
Pathbase: Curation
mast cell tumor
mouse_pathology.ontology
MPATH:349
obsolete; see MPATH507
mast cell tumor
true
mast cell tumor
Pathbase: Curation
Intra- or extracellular deposition of bile pigments and their metabolites.
mouse_pathology.ontology
MPATH:35
bile deposition
Intra- or extracellular deposition of bile pigments and their metabolites.
Pathbase: Pathology Committee
mastocytoma
mouse_pathology.ontology
MPATH:350
obsolete. See MPATH507
mastocytoma
true
mastocytoma
Pathbase: Curation
A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1).
mouse_pathology.ontology
MPATH:351
thymoma
A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1).
ISBN:0781727286
Tumors of the liver and biliary apparatus.
mouse_pathology.ontology
MPATH:352
hepatic tumor
Tumors of the liver and biliary apparatus.
Pathbase: Curation
Benign neoplasm derived from hepatocytes. (M- 8170/0).
mouse_pathology.ontology
hepatic adenoma, benign, liver cell tumor, benign
hepatoma, benign
nodule type A
MPATH:353
hepatocellular adenoma
Benign neoplasm derived from hepatocytes. (M- 8170/0).
Pathbase: Curation
hepatic adenoma, benign, liver cell tumor, benign
Pathbase: Curation
hepatoma, benign
Pathbase: Curation
nodule type A
Pathbase: Curation
Malignant tumor derived from the bile duct epithelium. (M8160/3).
mouse_pathology.ontology
MPATH:354
cholangiocarcinoma
Malignant tumor derived from the bile duct epithelium. (M8160/3).
Pathbase: Pathology Committee
Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant.
mouse_pathology.ontology
MPATH:355
cholangiofibroma
Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant.
Pathbase: Curation
Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3).
mouse_pathology.ontology
embryonal hepatoma
tumor, mixed, poorly differentiated
MPATH:356
hepatoblastoma
Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3).
Pathbase: Curation
embryonal hepatoma
Pathbase: Curation
tumor, mixed, poorly differentiated
Pathbase: Curation
Malignant tumor derived from hepatocytes. (M- 8170/3).
mouse_pathology.ontology
carcinoma, trabecular
carcinoma, trabecular (liver)
hepatoma, malignant
nodule type B
MPATH:357
hepatocellular carcinoma
Malignant tumor derived from hepatocytes. (M- 8170/3).
Book: Bannasche; P and Zerban; H. Preneoplastic and neoplastic lesions of the rat iver. In; Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 18-63
carcinoma, trabecular
Pathbase: Curation
carcinoma, trabecular (liver)
Pathbase: Curation
hepatoma, malignant
Pathbase: Curation
nodule type B
Pathbase: Curation
Tumors derived from melanocytes.
mouse_pathology.ontology
MPATH:358
melanocytic tumor
Tumors derived from melanocytes.
Pathbase: Pathology Committee
Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3).
URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/malignant_melanoma#melanoma_table
mouse_pathology.ontology
melanosarcoma
melanosarcoma, malignant melanoma
MPATH:359
melanoma
Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3).
Book: Klein-Szanto; A.J.; Neoplastic and preneoplastic lesions of the mouse skin; in Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 1-18
melanosarcoma
Pathbase: Curation
melanosarcoma, malignant melanoma
Pathbase: Curation
Intra or extracellular deposition of calcium usually as calcium phosphate.
mouse_pathology.ontology
MPATH:36
calcium deposition
Intra or extracellular deposition of calcium usually as calcium phosphate.
Pathbase: Curation
A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2).
mouse_pathology.ontology
level I melanoma
MPATH:360
melanoma in situ
A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2).
Pathbase: Pathology Committee
level I melanoma
Pathbase: Curation
Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0).
mouse_pathology.ontology
mole (sensu melanocytic nevus)
MPATH:361
naevus
Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0).
Pathbase: Pathology Committee
mole (sensu melanocytic nevus)
Pathbase: Curation
Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3).
mouse_pathology.ontology
mesonephric adenocarcinoma, wolffian duct carcinoma, mesonephroid tumor
MPATH:362
mesonephroma
Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3).
Pathbase: Pathology Committee
mesonephric adenocarcinoma, wolffian duct carcinoma, mesonephroid tumor
Pathbase: Curation
Tumor beleived to be derived from mesonephric remnants. (M-8310/3).
mouse_pathology.ontology
mesonephroid clear cell adenocarcinoma
MPATH:363
mesonephric tumor
Tumor beleived to be derived from mesonephric remnants. (M-8310/3).
Pathbase: Curation
mesonephroid clear cell adenocarcinoma
Pathbase: Curation
mesothelial tumor
mouse_pathology.ontology
MPATH:364
obsolete; subsumed into MPATH365
mesothelial tumor
true
mesothelial tumor
Pathbase: Curation
Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3).
mouse_pathology.ontology
MPATH:365
mesothelioma
Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3).
Pathbase: Curation
Neoplasms derived from the neuroendocrine system.
mouse_pathology.ontology
MPATH:366
neuroendocrine tumor
Neoplasms derived from the neuroendocrine system.
Pathbase: Curation
Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3).
mouse_pathology.ontology
MPATH:367
carcinoid tumor
Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3).
Pathbase: Pathology Committee
obsolete.
mouse_pathology.ontology
MPATH:368
endocrine adenocarcinoma
true
obsolete.
Pathbase: Curation
endocrine adenoma
mouse_pathology.ontology
MPATH:369
endocrine adenoma
true
endocrine adenoma
Pathbase: Curation
Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin.
mouse_pathology.ontology
MPATH:37
ceroid deposition
Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin.
Pathbase: Pathology Committee
Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3).
mouse_pathology.ontology
PNET
MPATH:370
primitive neurectodermal tumor
Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3).
ISBN-13:9783794515530
PNET
Pathbase: Curation
Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification.
URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
mouse_pathology.ontology
oat cell carcinoma
MPATH:371
see: Meuwissen, R., Linn, S.C., Linnoila, R.I. et al. (2003) Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer cell, 4: 181-189. AND Calbo, J., Meuwissen, R., van Montfort, E. et al. (2005) Genotype-phenotype relationships in a mouse model for human small-cell lung cancer. Cold Spring Harbor symposia on quantitative biology, 70: 225-232. AND Meuwissen, R. and Berns, A. (2005) Mouse models for human lung cancer. Genes & development, 19: 643-664.
small cell carcinoma
Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification.
PMID:15059877
oat cell carcinoma
Pathbase: Curation
Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1).
mouse_pathology.ontology
MPATH:372
tumorlet
Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1).
Pathbase: Pathology Committee
Neoplasms derived from neuroepithelial precursors.
mouse_pathology.ontology
MPATH:373
Renamed from neuroepitheliomatous tumor, to reflect primitive origins of this class of tumor.
CNS progenitor tumor
Neoplasms derived from neuroepithelial precursors.
Pathbase: Pathology Committee
A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3).
mouse_pathology.ontology
neuroblastoma, olfactory
neuroepithelial carcinoma
neuroepithelioma, olfactory
MPATH:374
esthesioneuroblastoma
A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3).
Pathbase: Curation
neuroblastoma, olfactory
Pathbase: Curation
neuroepithelial carcinoma
Pathbase: Curation
neuroepithelioma, olfactory
Pathbase: Curation
A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0).
mouse_pathology.ontology
MPATH:375
ganglioneuroma
A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0).
Pathbase: Pathology Committee
A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3).
mouse_pathology.ontology
MPATH:376
neuroblastoma
A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3).
ISBN-13:9783794515530
A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3).
mouse_pathology.ontology
MPATH:377
pheochromocytoma
A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3).
Pathbase: Pathology Committee
Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3).
mouse_pathology.ontology
MPATH:378
retinoblastoma
Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3).
Pathbase: Curation
Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) .
mouse_pathology.ontology
MPATH:379
odontogenic tumor
Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) .
Pathbase: Pathology Committee
Intra and extracellular deposition of copper and copper containing proteins.
mouse_pathology.ontology
MPATH:38
copper deposition
Intra and extracellular deposition of copper and copper containing proteins.
Pathbase: Curation
A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0).
mouse_pathology.ontology
MPATH:380
ameloblastic fibroma
A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0).
Pathbase: Pathology Committee
Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0).
mouse_pathology.ontology
MPATH:381
ameloblastoma
Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0).
Pathbase: Pathology Committee
Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0).
mouse_pathology.ontology
ossifying fibroma, cemento-ossifying fibroma
MPATH:382
cementifying fibroma
Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0).
Pathbase: Curation
ossifying fibroma, cemento-ossifying fibroma
Pathbase: Curation
A neoplasm arising from the periodontal ligament (M-9273/0).
mouse_pathology.ontology
True cementoma
MPATH:383
cementoblastoma
A neoplasm arising from the periodontal ligament (M-9273/0).
Pathbase: Curation
True cementoma
Pathbase: Curation
Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0).
mouse_pathology.ontology
MPATH:384
cementoma
Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0).
Pathbase: Curation
Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0).
mouse_pathology.ontology
ameloblastic fibrodentinoma
MPATH:385
dentinoma
Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0).
Pathbase: Curation
ameloblastic fibrodentinoma
Pathbase: Curation
odontogenic tumor
mouse_pathology.ontology
MPATH:386
redundant
odontogenic tumor
true
odontogenic tumor
Pathbase: Curation
Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0).
mouse_pathology.ontology
MPATH:387
odontoma
Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0).
ISBN:0781727286
Neoplasms of bone and cartilage.
mouse_pathology.ontology
MPATH:388
osseous and chondromatous tumor
Neoplasms of bone and cartilage.
Pathbase: Curation
A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3).
mouse_pathology.ontology
MPATH:389
chondroblastoma
A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3).
Pathbase: Pathology Committee
Intracellular deposition of glycogen.
mouse_pathology.ontology
MPATH:39
glycogen deposition
Intracellular deposition of glycogen.
Pathbase: Curation
chondroblastoma, malignant
mouse_pathology.ontology
MPATH:390
Subsumed into MPATH:389
chondroblastoma, malignant
true
chondroblastoma, malignant
Pathbase: Curation
A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0).
mouse_pathology.ontology
MPATH:391
chondroma
A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0).
Pathbase: Curation
Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3).
mouse_pathology.ontology
MPATH:392
chondrosarcoma
Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3).
Pathbase: Pathology Committee
Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0).
mouse_pathology.ontology
giant osteoid osteoma, benign osteoblastoma
MPATH:393
osteoblastoma
Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0).
Pathbase: Pathology Committee
giant osteoid osteoma, benign osteoblastoma
Pathbase: Curation
Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0).
mouse_pathology.ontology
cartilaginous exostosis
MPATH:394
osteochondroma
Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0).
Pathbase: Pathology Committee
cartilaginous exostosis
Pathbase: Curation
Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0).
mouse_pathology.ontology
MPATH:395
osteofibroma
Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0).
Pathbase: Curation
Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0).
mouse_pathology.ontology
cancellous osteoma
compact osteoma
juxtacortical osteoma
medullary osteoma
osteoid osteoma
spongious osteoma
trabecular osteoma
MPATH:396
osteoma
Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0).
Book: Luz; A and Gessner; W. ; Neoplastic bone lesions of the mouse; in Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 142-154
cancellous osteoma
Pathbase: Curation
compact osteoma
Pathbase: Curation
juxtacortical osteoma
Pathbase: Curation
medullary osteoma
Pathbase: Curation
osteoid osteoma
Pathbase: Curation
spongious osteoma
Pathbase: Curation
trabecular osteoma
Pathbase: Curation
Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3).
mouse_pathology.ontology
osteogenic sarcoma
MPATH:397
osteosarcoma
Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3).
Pathbase: Curation
osteogenic sarcoma
Pathbase: Curation
Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma.
mouse_pathology.ontology
MPATH:398
paragangliomas and glomus tumor
Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma.
Pathbase: Curation
Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1).
mouse_pathology.ontology
aortic body paraganglioma
MPATH:399
aortic body tumor
Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1).
Pathbase: Curation
aortic body paraganglioma
Pathbase: Curation
Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3.
mouse_pathology.ontology
MPATH:4
necrosis
Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3.
ISBN:0781727286
Intracellular deposition of eosinophilic material.
mouse_pathology.ontology
Hyaline degeneration, Eosinophilic cytoplasmic change
MPATH:40
hyalinosis
Intracellular deposition of eosinophilic material.
PMID: 11794381
Hyaline degeneration, Eosinophilic cytoplasmic change
Pathbase: Curation
Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1).
mouse_pathology.ontology
carotid body paraganglioma
MPATH:400
carotid body tumor
Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1).
Pathbase: Pathology Committee
carotid body paraganglioma
Pathbase: Curation
A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1).
mouse_pathology.ontology
MPATH:401
glomus jugulare tumor
A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1).
Pathbase: Curation
glomus tumor
mouse_pathology.ontology
MPATH:402
obsolete; use paraganglioma M-8711/0) or specific example terms, MPATH399-401.
glomus tumor
true
glomus tumor
Pathbase: Curation
A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0).
mouse_pathology.ontology
chemodectomas
glomus tumor
non-chromaffin paragangliomas
MPATH:403
paraganglioma
A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0).
Pathbase: Curation
chemodectomas
Pathbase: Curation
glomus tumor
Pathbase: Curation
non-chromaffin paragangliomas
Pathbase: Curation
Neoplasms of the soft and connective tissues.
mouse_pathology.ontology
MPATH:404
soft tissue tumor
Neoplasms of the soft and connective tissues.
Pathbase: Curation
Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3).
mouse_pathology.ontology
MPATH:405
chordoma
Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3).
Pathbase: Curation
Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3).
mouse_pathology.ontology
MPATH:406
dermatofibrosarcoma
Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3).
Pathbase: Curation
Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0).
mouse_pathology.ontology
MPATH:407
"Soft tissue" qualifier removed by Pathology Panel to increase scope of term.
fibroma
Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0).
Pathbase: Pathology Committee
Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3).
fibrosarcoma
mouse_pathology.ontology
MPATH:408
soft tissue fibrosarcoma
Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3).
Pathbase: Pathology Committee
Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0).
mouse_pathology.ontology
MPATH:409
fibrous histiocytoma
Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0).
Pathbase: Curation
Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin.
mouse_pathology.ontology
MPATH:41
iron deposition
Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin.
Pathbase: Curation
Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1).
mouse_pathology.ontology
giant cell fibrous histiocytoma
MPATH:410
giant cell tumor of soft tissue
Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1).
Pathbase: Pathology Committee
giant cell fibrous histiocytoma
Pathbase: Curation
granular cell tumor/alveolar sarcoma
mouse_pathology.ontology
MPATH:411
obsolete. Use specific terms MPATH: 412 or MPATH: 413
granular cell tumor/alveolar sarcoma
true
granular cell tumor/alveolar sarcoma
Pathbase: Curation
Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3).
mouse_pathology.ontology
MPATH:412
alveolar soft part sarcoma
Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3).
Pathbase: Pathology Committee
Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0).
mouse_pathology.ontology
myoblastoma
MPATH:413
granular cell tumor
Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0).
Pathbase: Pathology Committee
myoblastoma
Pathbase: Curation
histiocytic sarcoma
mouse_pathology.ontology
MPATH:414
redundant use MPATH506
histiocytic sarcoma
true
histiocytic sarcoma
Pathbase: Curation
Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation.
mouse_pathology.ontology
MPATH:415
lipomatous tumor
Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation.
Pathbase: Curation
Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0).
mouse_pathology.ontology
MPATH:416
angiomyolipoma
Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0).
Pathbase: Pathology Committee
Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0).
mouse_pathology.ontology
MPATH:417
lipoma
Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0).
Pathbase: Pathology Committee
Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3).
mouse_pathology.ontology
MPATH:418
liposarcoma
Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3).
Pathbase: Pathology Committee
Neoplasms of the lymphatic vessels.
mouse_pathology.ontology
MPATH:419
lymphatic vessel tumor
Neoplasms of the lymphatic vessels.
Pathbase: Curation
Extra or intracellular deposition of lipid.
mouse_pathology.ontology
MPATH:42
lipid deposition
Extra or intracellular deposition of lipid.
Pathbase: Curation
Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0).
Hygroma
mouse_pathology.ontology
MPATH:420
lymphangioma
Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0).
ISBN:0781727286
Hygroma
ISBN:0-19-261976-4
Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1).
mouse_pathology.ontology
Lymphangioleiomyomatosis.
MPATH:421
lymphangiomyomatosis
Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1).
Pathbase: Curation
Lymphangioleiomyomatosis.
Pathbase: Curation
A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3).
mouse_pathology.ontology
MPATH:422
lymphangiosarcoma
A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3).
Pathbase: Curation
Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation.
mouse_pathology.ontology
MPATH:423
myomatous tumor
Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation.
Pathbase: Curation
Benign leiomyoma that invades vascular spaces. (M-8890/1).
mouse_pathology.ontology
MPATH:424
intravascular leiomyomatosis
Benign leiomyoma that invades vascular spaces. (M-8890/1).
Pathbase: Curation
Benign neoplasm derived from smooth muscle cells. (M-8890/0).
mouse_pathology.ontology
MPATH:425
leiomyoma
Benign neoplasm derived from smooth muscle cells. (M-8890/0).
Pathbase: Curation
Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3).
mouse_pathology.ontology
MPATH:426
leiomyosarcoma
Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3).
Pathbase: Curation
myoblastoma
mouse_pathology.ontology
MPATH:427
obsolete. Syn of granular cell tumor. MPATH 413
myoblastoma
true
myoblastoma
Pathbase: Curation
Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3).
mouse_pathology.ontology
MPATH:428
rhabdomyosarcoma
Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3).
Pathbase: Curation
Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix.
mouse_pathology.ontology
MPATH:429
myxomatous tumor
Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix.
Pathbase: Curation
Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related.
mouse_pathology.ontology
MPATH:43
lipofuscin deposition
Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related.
Pathbase: Pathology Committee
Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1).
mouse_pathology.ontology
MPATH:430
angiomyxoma
Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1).
Pathbase: Curation
A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0).
mouse_pathology.ontology
MPATH:431
myxoma
A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0).
Pathbase: Pathology Committee
A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3).
mouse_pathology.ontology
MPATH:432
myxosarcoma
A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3).
Pathbase: Curation
Neoplasms of the nerve sheath.
mouse_pathology.ontology
MPATH:433
nerve sheath tumor
Neoplasms of the nerve sheath.
Pathbase: Pathology Committee
neurilemmoma
mouse_pathology.ontology
MPATH:434
obsolete. Use schwannoma MPATH438
neurilemmoma
true
neurilemmoma
Pathbase: Curation
Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0).
mouse_pathology.ontology
MPATH:435
neurofibroma
Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0).
ISBN-13:9783794515530
Systemic manifestation of MPATH:435 ( M-9540/1).
mouse_pathology.ontology
MPATH:436
neurofibromatosis
Systemic manifestation of MPATH:435 ( M-9540/1).
Pathbase: Curation
Malignant neoplasm derived from Schwann cells. (M-9540/3).
mouse_pathology.ontology
malignant peripheral nerve sheath tumor
MPATH:437
neurofibrosarcoma
Malignant neoplasm derived from Schwann cells. (M-9540/3).
ISBN-13:9783794515530
malignant peripheral nerve sheath tumor
Pathbase: Curation
May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0).
mouse_pathology.ontology
neurilemoma
neurinoma, benign
MPATH:438
schwannoma
May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0).
ISBN-13:9783794515530
neurilemoma
Pathbase: Curation
neurinoma, benign
Pathbase: Curation
Neoplasms of synovial origin.
mouse_pathology.ontology
MPATH:439
synovial-like tumor
Neoplasms of synovial origin.
Pathbase: Curation
Intra or extracellular deposition of melanin.
mouse_pathology.ontology
MPATH:44
melanin deposition
Intra or extracellular deposition of melanin.
Pathbase: Pathology Committee
Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3).
mouse_pathology.ontology
Synovial cell sarcoma
MPATH:440
synovial sarcoma
Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3).
Pathbase: Pathology Committee
Synovial cell sarcoma
Pathbase: Curation
synovioma
mouse_pathology.ontology
MPATH:441
Obsolete. Use MPATH:440
synovioma
true
synovioma
Pathbase: Curation
Neoplasms of stratified squamous epithelial cells.
mouse_pathology.ontology
MPATH:442
squamous cell tumor
Neoplasms of stratified squamous epithelial cells.
Pathbase: Pathology Committee
A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0).
mouse_pathology.ontology
endophytic papilloma
invaginated papilloma
MPATH:443
inverted squamous papilloma
A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0).
Pathbase: Pathology Committee
endophytic papilloma
Pathbase: Curation
invaginated papilloma
Pathbase: Curation
Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses.
mouse_pathology.ontology
epithelioma, intracutaneous, cornifying
MPATH:444
keratoacanthoma
Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses.
Pathbase: Pathology Committee
epithelioma, intracutaneous, cornifying
Pathbase: Curation
A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0).
mouse_pathology.ontology
MPATH:445
papilloma
A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0).
Pathbase: Pathology Committee
Malignant tumor derived from stratified squamous cells. (M-8070/3).
mouse_pathology.ontology
carcinoma, epidermoid ( sensu epidermal derived tumors)
MPATH:446
squamous cell carcinoma
Malignant tumor derived from stratified squamous cells. (M-8070/3).
Pathbase: Pathology Committee
carcinoma, epidermoid ( sensu epidermal derived tumors)
Pathbase: Curation
Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2).
mouse_pathology.ontology
IENIII
severe intra-epithelial neoplasia
MPATH:447
squamous cell carcinoma in situ
Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2).
Pathbase: Pathology Committee
IENIII
Pathbase: Curation
severe intra-epithelial neoplasia
Pathbase: Curation
A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells.
mouse_pathology.ontology
Exophytic papilloma
MPATH:448
squamous cell papilloma
A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells.
Pathbase: Pathology Committee
Exophytic papilloma
Pathbase: Curation
A well-differentiated papillary squamous cell carcinoma. (M-8051/3).
mouse_pathology.ontology
MPATH:449
verrucous carcinoma
A well-differentiated papillary squamous cell carcinoma. (M-8051/3).
Pathbase: Curation
Non-specified intra or extracellular deposition of protein.
mouse_pathology.ontology
MPATH:45
protein deposition
Non-specified intra or extracellular deposition of protein.
Pathbase: Curation
Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix.
mouse_pathology.ontology
MPATH:450
transitional cell tumor
Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix.
Pathbase: Pathology Committee
Malignant neoplasm of transitional cells (M-8120/3).
mouse_pathology.ontology
MPATH:451
transitional cell carcinoma
Malignant neoplasm of transitional cells (M-8120/3).
Pathbase: Curation
Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2).
mouse_pathology.ontology
severe intra-epithelial neoplasia
MPATH:452
transitional cell carcinoma in situ
Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2).
Pathbase: Pathology Committee
severe intra-epithelial neoplasia
Pathbase: Curation
Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1).
mouse_pathology.ontology
MPATH:453
transitional cell papilloma
Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1).
Pathbase: Pathology Committee
Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins.
mouse_pathology.ontology
MPATH:454
trophoblastic tumor
Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins.
Pathbase: Curation
Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3).
mouse_pathology.ontology
Chorioepithelioma, malignant.
MPATH:455
choriocarcinoma
Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3).
Pathbase: Pathology Committee
Chorioepithelioma, malignant.
Pathbase: Curation
Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0).
mouse_pathology.ontology
cystic mole
gestational trophoblastic disease
MPATH:456
hydatidiform mole
Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0).
Pathbase: Curation
cystic mole
Pathbase: Curation
gestational trophoblastic disease
Pathbase: Curation
Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1).
mouse_pathology.ontology
MPATH:457
placental site trophoblastic tumor
Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1).
Pathbase: Pathology Committee
No pathological entity observable.
mouse_pathology.ontology
MPATH:458
normal
No pathological entity observable.
Pathbase: Pathology Committee
obsolete
mouse_pathology.ontology
MPATH:459
obsolete
true
obsolete
Pathbase: Pathology Committee
Extracellular deposition of uric acid crystals.
mouse_pathology.ontology
MPATH:46
uric acid deposition
Extracellular deposition of uric acid crystals.
Pathbase: Curation
Defect in the structure or function of the nuclear membrane or matrix or other component.
mouse_pathology.ontology
MPATH:460
nuclear defect
Defect in the structure or function of the nuclear membrane or matrix or other component.
Pathbase: Curation
Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin.
mouse_pathology.ontology
MPATH:461
cataract; capsular-epithelial
Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin.
ISBN:08493086 4X
Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule.
mouse_pathology.ontology
MPATH:462
cataract; nuclear and cortical
Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule.
ISBN:08493086 4X
Of developmental origins; nucleus and cortex become completely liquefied in post-natal life.
mouse_pathology.ontology
MPATH:463
cataract; cortical liquefactive
Of developmental origins; nucleus and cortex become completely liquefied in post-natal life.
ISBN:08493086 4X
Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye.
mouse_pathology.ontology
MPATH:464
cataract; lens extrusion
Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye.
ISBN:08493086 4X
Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle.
mouse_pathology.ontology
MPATH:465
glaucoma developmental
Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle.
ISBN:08493086 4X
Failure of drainage of the eye for unknown reasons.
mouse_pathology.ontology
MPATH:466
glaucoma; open angle
Failure of drainage of the eye for unknown reasons.
ISBN:08493086 4X
Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions.
mouse_pathology.ontology
MPATH:467
glaucoma; angle closure
Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions.
ISBN:08493086 4X
Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances.
mouse_pathology.ontology
MPATH:468
pseudocyst
Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances.
Pathbase: Pathology Committee
Any aberration of the normal symmetrical organisation of the body pattern.
mouse_pathology.ontology
MPATH:469
symmetry defect
Any aberration of the normal symmetrical organisation of the body pattern.
Pathbase: Curation
Loss or dispersion of specific intra- and extracellular substances.
mouse_pathology.ontology
MPATH:47
intracellular and extracellular depletion
Loss or dispersion of specific intra- and extracellular substances.
Pathbase: Pathology Committee
Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern.
mouse_pathology.ontology
MPATH:470
For example as seen in the mutation <situs inversus>.
left/right axis defect
Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern.
Pathbase: Pathology Committee
Anteroposterior aberration of the normal symmetrical organisation of the body pattern.
mouse_pathology.ontology
MPATH:471
anterior/posterior axis defect
Anteroposterior aberration of the normal symmetrical organisation of the body pattern.
Pathbase: Curation
Dorsoventral aberration of the normal symmetrical organisation of the body pattern.
mouse_pathology.ontology
MPATH:472
dorsal/ventral axis defect
Dorsoventral aberration of the normal symmetrical organisation of the body pattern.
Pathbase: Curation
Developmental dysplasia showing epithelial cell bounded cavities.
mouse_pathology.ontology
MPATH:473
developmental cystic dysplasia
Developmental dysplasia showing epithelial cell bounded cavities.
Pathbase: Pathology Committee
Dilation of a tubular structure.
mouse_pathology.ontology
MPATH:474
Often associated with an obstruction.
ectasia
Dilation of a tubular structure.
Pathbase: Pathology Committee
Dilation of a ductal structure.
mouse_pathology.ontology
MPATH:475
ductal ectasia
Dilation of a ductal structure.
Pathbase: Curation
A lesion formed by a dilated capillary or terminal artery.
mouse_pathology.ontology
MPATH:476
telangiectasia
A lesion formed by a dilated capillary or terminal artery.
Pathbase: Curation
Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly).
mouse_pathology.ontology
Choristoblastoma
MPATH:477
choristoma
Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly).
ISBN:0781727286
Choristoblastoma
Pathbase: Curation
Abnormality in developmental angiogenesis.
mouse_pathology.ontology
MPATH:478
angiogenesis defect
Abnormality in developmental angiogenesis.
Pathbase: Pathology Committee
Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells.
mouse_pathology.ontology
MPATH:479
vasculogenesis defect
Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells.
Pathbase: Pathology Committee
Process of loss of calcium from normally calcified tissue, usually bone.
mouse_pathology.ontology
MPATH:48
decalcification
Process of loss of calcium from normally calcified tissue, usually bone.
Pathbase: Curation
Any defect in the formation, architecture, cellular composition or function of the maternal decidua.
mouse_pathology.ontology
MPATH:480
decidual defect
Any defect in the formation, architecture, cellular composition or function of the maternal decidua.
Pathbase: Curation
Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous.
mouse_pathology.ontology
MPATH:481
Obsolete; replaced by potentially pre-cancerous lesions (MPATH 556) as many are actually neoplastic but do not progress to cancer.
pre-neoplastic lesions
true
Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous.
Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128
Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy.
mouse_pathology.ontology
MPATH:482
focal hyperplasia
Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy.
Pathbase: Pathology Committee
Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma.
mouse_pathology.ontology
MPATH:483
Considered to be too vague to be useful.
atypical hyperplasia
true
Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma.
Pathbase: Pathology Committee
Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells.
mouse_pathology.ontology
hyperplastic nodules
nodular hyperplasia
MPATH:484
hyperplastic nodule
Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells.
Pathbase: Pathology Committee
hyperplastic nodules
Pathbase: Curation
May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion.
mouse_pathology.ontology
severe epithelial dysplasia
severe intraepithelial neoplasia
MPATH:485
Subsumed into MPATH: 132
carcinoma in situ
true
May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion.
Pathbase: Pathology Committee
severe epithelial dysplasia
Pathbase: Curation
severe intraepithelial neoplasia
Pathbase: Curation
Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors.
mouse_pathology.ontology
DIN
Ductal carcinoma in situ
MIN
intraductal adenocarcinoma, non-infiltrating
mammary intra-epithelial neoplasia
MPATH:486
This term covers the range of DIN (MIN) including severe intra-epithelial neoplasia (IENIII), alternatively termed in situ carcinoma of the mammary ductal epithelium. (M- 8500/2). See Tavassoli FA. (1998) Mod Pathol. 11:140-54. Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia for further definition.
ductal intra-epithelial neoplasia
Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors.
PMID:10713680
DIN
Pathbase: Curation
Ductal carcinoma in situ
Pathbase: Curation
MIN
Pathbase: Curation
intraductal adenocarcinoma, non-infiltrating
Pathbase: Curation
mammary intra-epithelial neoplasia
Pathbase: Curation
Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands.
mouse_pathology.ontology
GIN
IIN
microadenoma
MPATH:487
intestinal intra-epithelial neoplasia
Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands.
PMID:12612914
GIN
Pathbase: Curation
IIN
Pathbase: Curation
microadenoma
Pathbase: Curation
See reference for definition.
URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/prostate_models/path_class_mouse
mouse_pathology.ontology
PIN
MPATH:488
prostate intra-epithelial neoplasia
See reference for definition.
ISBN:0-19-512338-7
PIN
Pathbase: Curation
stomach, oesophagus and pancreatic intra-epithelial neoplasia
mouse_pathology.ontology
PANIN
MPATH:489
stomach, oesophagus and pancreatic intra-epithelial neoplasia
stomach, oesophagus and pancreatic intra-epithelial neoplasia
ISBN:0-19-512338-7
PANIN
Pathbase: Curation
Reduction of myelin content in neuronal sheath.
mouse_pathology.ontology
MPATH:49
demyelination
Reduction of myelin content in neuronal sheath.
Pathbase: Curation
Benign neoplastic growth containing areas of adenomatous structure (progression).
mouse_pathology.ontology
polypoid adenoma, cellular polyp.
MPATH:490
adenomatous polyp
Benign neoplastic growth containing areas of adenomatous structure (progression).
Pathbase: Curation
polypoid adenoma, cellular polyp.
Pathbase: Curation
A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk.
mouse_pathology.ontology
MPATH:491
polyp
A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk.
ISBN:0781727286
Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,.
mouse_pathology.ontology
MPATH:492
membraneous glomerulonephritis
Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,.
ISBN:0781727286
A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,.
mouse_pathology.ontology
MPATH:493
membraneoproliferative glomerulonephritis
A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,.
ISBN:0781727286
Glomerulonephritis caused by autoimmune attack on the glomerulus.
mouse_pathology.ontology
MPATH:494
Needs multiple parentage with autoimmune mediated disease
autoimmune glomerulonephritis
Glomerulonephritis caused by autoimmune attack on the glomerulus.
ISBN:0781727286
Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0).
mouse_pathology.ontology
MPATH:495
glomangioma
Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0).
Pathbase: Curation
Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:496
Non-Lymphoid leukaemias
Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition.
PMID:12070033
Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
myeloblastic leukaemia without maturation
myeloid leukaemia (myeloblastic type)
poorly differentiated myeloid leukaemia
MPATH:497
myeloid leukaemia without maturation
Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts.
PMID:12070033
myeloblastic leukaemia without maturation
Pathbase: Curation
myeloid leukaemia (myeloblastic type)
Pathbase: Curation
poorly differentiated myeloid leukaemia
Pathbase: Curation
Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
myeloblastic laeukaemia with maturation
poorly differentiated myeloid leukaemia
MPATH:498
myeloid leukaemia with maturation
Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts.
PMID:12070033
myeloblastic laeukaemia with maturation
Pathbase: Curation
poorly differentiated myeloid leukaemia
Pathbase: Curation
Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion.
mouse_pathology.ontology
Beta-cell nesidioblastosis
congenital insulinomas
diffused or generalised islet cell hyperplasia
endocrine dysplasia
focal adenomatosis
microadenomatosis
multifocal and focal ductulo-insular proliferation (nesidioblastosis)
nesidioblastoma
nesidiodysplasia
MPATH:499
nesidioblastosis
Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion.
PMCID: 1964945
Beta-cell nesidioblastosis
Pathbase: Curation
congenital insulinomas
Pathbase: Curation
diffused or generalised islet cell hyperplasia
Pathbase: Curation
endocrine dysplasia
Pathbase: Curation
focal adenomatosis
Pathbase: Curation
microadenomatosis
Pathbase: Curation
multifocal and focal ductulo-insular proliferation (nesidioblastosis)
Pathbase: Curation
nesidioblastoma
Pathbase: Curation
nesidiodysplasia
Pathbase: Curation
Area of liver necrosis that bridges adjacent portal areas and central veins.
mouse_pathology.ontology
MPATH:5
bridging necrosis
Area of liver necrosis that bridges adjacent portal areas and central veins.
ISBN:0781727286
Reduction in intracellular glycogen content.
mouse_pathology.ontology
MPATH:50
glycogen depletion
Reduction in intracellular glycogen content.
Pathbase: Curation
Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
myeloid leukaemia, chonic type
well differentiated myeloid leukaemia
MPATH:500
myeloproliferative disease-like myeloid leukaemia
Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts.
PMID:12070033
myeloid leukaemia, chonic type
Pathbase: Curation
well differentiated myeloid leukaemia
Pathbase: Curation
Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
myeloid leukaemia, myelomonocytic type
MPATH:501
myelomonocytic leukaemia
Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts.
PMID:12070033
myeloid leukaemia, myelomonocytic type
Pathbase: Curation
Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:502
monocytic leukaemia
Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts.
PMID:12070033
A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:503
biphenotypic leukaemia
A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage.
PMID:12070033
Solid tumor mass composed of non-lymphoid haematopoietic cells.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:504
non-lymphoid hematopoietic sarcomas
Solid tumor mass composed of non-lymphoid haematopoietic cells.
PMID:12070033
Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:505
granulocytic sarcoma
Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells.
PMID:12070033
Solid tumor mass composed predominantly of histiocytic cells (M-9775/3).
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
Kupffer cell sarcoma (sensu liver)
histiocytic lymphoma
malignant lymphoma, histiocytic type
reticulum cell sarcoma, type A
reticulum cell sarcoma, type A, reticulosarcoma
MPATH:506
histiocytic sarcoma
Solid tumor mass composed predominantly of histiocytic cells (M-9775/3).
PMID:12070033
Kupffer cell sarcoma (sensu liver)
Pathbase: Curation
histiocytic lymphoma
Pathbase: Curation
malignant lymphoma, histiocytic type
Pathbase: Curation
reticulum cell sarcoma, type A
Pathbase: Curation
reticulum cell sarcoma, type A, reticulosarcoma
Pathbase: Curation
Solid tumor mass composed of mast cells.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
malignant mastocytoma
mast cell tumor
mastocytosis
MPATH:507
mast cell sarcoma
Solid tumor mass composed of mast cells.
PMID:12070033
malignant mastocytoma
Pathbase: Curation
mast cell tumor
Pathbase: Curation
mastocytosis
Pathbase: Curation
Haematopoietic proliferation with evidence of trilineage dysplasia.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:508
myeloid dysplasias
Haematopoietic proliferation with evidence of trilineage dysplasia.
PMID:12070033
Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:509
cytopenia with increased blasts
Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts.
PMID:12070033
Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48.
mouse_pathology.ontology
MPATH:51
hypocalcification
Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48.
Pathbase: Curation
Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:510
myeloid proliferations (non-reactive)
Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined.
PMID:12070033
Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:511
myeloproliferation (genetic)
Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined.
PMID:12070033
Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:512
myeloproliferative disease
Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow.
PMID:12070033
Neoplasms of the B or T cell lineage.
mouse_pathology.ontology
MPATH:513
lymphoid neoplasms
Neoplasms of the B or T cell lineage.
PMID:12070034
B cell neoplasms
mouse_pathology.ontology
MPATH:514
B cell neoplasms
true
B cell neoplasms
Pathbase: Pathology Committee
Hematological neoplasias of non-lymphoid origin.
URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
mouse_pathology.ontology
MPATH:515
non-Lymphoid neoplasias
Hematological neoplasias of non-lymphoid origin.
PMID:12070033
Neoplasm of the B cell lymphoid lineage.
mouse_pathology.ontology
MPATH:516
B-cell neoplasms
Neoplasm of the B cell lymphoid lineage.
Pathbase: Curation
Lymphoma originating from precursor B-cells.
mouse_pathology.ontology
MPATH:517
precursor B cell neoplasms
Lymphoma originating from precursor B-cells.
PMID:12070034
Lymphoma originating in a precursor B-cell.
mouse_pathology.ontology
lymphoblastic leukaemia
lymphoblastic lymphoma
MPATH:518
precursor B -cell lymphoblastic lymphoma/leukaemia
Lymphoma originating in a precursor B-cell.
PMID:12070034
lymphoblastic leukaemia
Pathbase: Curation
lymphoblastic lymphoma
Pathbase: Curation
Lymphomas originating in peripheral B cells.
mouse_pathology.ontology
MPATH:519
mature B-cell neoplasms
Lymphomas originating in peripheral B cells.
PMID:12070034
Reduction in cellular or plasma lipid content.
mouse_pathology.ontology
MPATH:52
lipid depletion
Reduction in cellular or plasma lipid content.
Pathbase: Curation
Diffuse accumulation of small mature B-cells.
mouse_pathology.ontology
small lymphocytic lymphoma
well differentiated lymphocytic lymphoma
MPATH:520
small B-cell lymphoma
Diffuse accumulation of small mature B-cells.
Book: Morse; et al. (2002) Blood 100; 246-258
small lymphocytic lymphoma
Pathbase: Curation
well differentiated lymphocytic lymphoma
Pathbase: Curation
A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen.
mouse_pathology.ontology
SMZL
MPATH:521
splenic marginal zone lymphoma
A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen.
PMID:12070034
SMZL
Pathbase: Curation
A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse.
mouse_pathology.ontology
centroblastic/centrocytic lymphoma
follicular center cell lymphoma, small cell or mixed
follicular lymphoma
MPATH:522
follicular B cell lymphoma
A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse.
PMID:12070034
centroblastic/centrocytic lymphoma
Pathbase: Curation
follicular center cell lymphoma, small cell or mixed
Pathbase: Curation
follicular lymphoma
Pathbase: Curation
Diffuse proliferation of large B lymphoid cells.
mouse_pathology.ontology
DLBCL
MPATH:523
diffuse large B-cell lymphoma
Diffuse proliferation of large B lymphoid cells.
PMID:12070034
DLBCL
Pathbase: Curation
Diffuse follicular centre cell lymphoma mainly composed of centroblasts.
mouse_pathology.ontology
centroblastic lymphoma
MPATH:524
diffuse large B-cell lymphoma, centroblastic type
Diffuse follicular centre cell lymphoma mainly composed of centroblasts.
PMID:12070034
centroblastic lymphoma
Pathbase: Curation
Diffuse large B cell lymphoma with increased number of immunoblasts.
mouse_pathology.ontology
Immunoblastic lymphoma
MPATH:525
diffuse large B-cell lymphoma, immunoblastic type
Diffuse large B cell lymphoma with increased number of immunoblasts.
PMID:12070034
Immunoblastic lymphoma
Pathbase: Curation
Diffuse large B-cell lymphoma with more than 50% histiocytes.
mouse_pathology.ontology
DLCL (HS)
MPATH:526
diffuse large B-cell lymphoma, histiocyte associated
Diffuse large B-cell lymphoma with more than 50% histiocytes.
PMID:12070034
DLCL (HS)
Pathbase: Curation
Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease.
mouse_pathology.ontology
MPATH:527
primary mediastinal (thymic) diffuse large B cell lymphoma
Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease.
PMID:12070034
Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells.
mouse_pathology.ontology
MPATH:528
classic Burkitt lymphoma
Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells.
PMID:12070034
Highly proliferative mature B-cell lymphoma, poorly defined.
mouse_pathology.ontology
MPATH:529
Burkitt-like lymphoma
Highly proliferative mature B-cell lymphoma, poorly defined.
PMID:12070034
Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification.
mouse_pathology.ontology
MPATH:53
osteopenia
Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification.
ISBN:0781727286
Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3).
URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class
mouse_pathology.ontology
Myeloma ( human )
MPATH:530
plasma cell neoplasms
Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3).
PMID:12070034
Myeloma ( human )
Pathbase: Curation
Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype.
mouse_pathology.ontology
MPATH:531
B-natural killer cell lymphoma
Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype.
Lu; L-M.; et al (1999) Jpn J. Cancer Res. 90: 1218-1223
Diffuse proliferation of mature plasma cells. Clonal by definition.
URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class
mouse_pathology.ontology
MPATH:532
Tissue, usually lymph nodes, that contain unusually large numbers of normal appearing plasma cells. While these may be plasmacytomas, additional work is needed to confirm this latter diagnosis.
plasmacytoma
Diffuse proliferation of mature plasma cells. Clonal by definition.
PMID:12070034
Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum.
mouse_pathology.ontology
MPATH:533
extraosseous plasmacytoma
Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum.
PMID:12070034
Diffuse proliferation of immature plasma cells or plasma blasts.
mouse_pathology.ontology
MPATH:534
anaplastic plasmacytoma
Diffuse proliferation of immature plasma cells or plasma blasts.
PMID:12070034
Neoplasms derived from cells of the T lymphocyte lineage.
mouse_pathology.ontology
MPATH:535
T-cell neoplasms
Neoplasms derived from cells of the T lymphocyte lineage.
PMID:12070034
Neoplasms of precursor T cells.
mouse_pathology.ontology
MPATH:536
precursor T-cell neoplasms
Neoplasms of precursor T cells.
PMID:12070034
Precursor T cell derived neoplasia. Most commonly found in the thymus.
mouse_pathology.ontology
thymic lymphoma
MPATH:537
precursor T-cell lymphoblastic lymphoma/leukaemia
Precursor T cell derived neoplasia. Most commonly found in the thymus.
PMID:12070034
thymic lymphoma
Pathbase: Curation
Non-thymic neoplasms of mature T cell origin.
mouse_pathology.ontology
MPATH:538
mature T-cell neoplasms
Non-thymic neoplasms of mature T cell origin.
PMID:12070034
Accumulation of small mature T cells. No human counterpart known to date.
mouse_pathology.ontology
MPATH:539
small T-cell lymphoma
Accumulation of small mature T cells. No human counterpart known to date.
PMID:12070034
Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix.
mouse_pathology.ontology
MPATH:54
osteoporosis
Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix.
ISBN:0781727286
T cell neoplasms which cannot currently be classified into known subtypes.
mouse_pathology.ontology
MPATH:540
T cell neoplasms character undetermined
T cell neoplasms which cannot currently be classified into known subtypes.
PMID:12070034
Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma.
mouse_pathology.ontology
MPATH:541
T large cell anaplastic lymphoma
Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma.
PMID:12070034
Neoplasm of large granular T cells of CD8 phenotype.
mouse_pathology.ontology
MPATH:542
T natural killer cell lymphoma
Neoplasm of large granular T cells of CD8 phenotype.
PMID:12070034
Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0).
mouse_pathology.ontology
MPATH:543
cholangioma
Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0).
Pathbase: Pathology Committee
Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma.
mouse_pathology.ontology
MPATH:544
hepatocholangiocellular adenoma
Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma.
Pathbase: Pathology Committee
Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3).
mouse_pathology.ontology
MPATH:545
hepatocholangiocellular carcinoma
Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3).
Pathbase: Pathology Committee
George Gkoutos
2011-03-22T03:07:49Z
mouse_pathology.ontology
MPATH:546
blepharitis
Extracellular accumulation of mucous secretions.
mouse_pathology.ontology
MPATH:547
Mucus is the clear viscous secretion of the mucous membranes. Consisting of mucin, epithelial cells, leukocytes and various inorganic salts dissolved in water.
mucous secretions
Extracellular accumulation of mucous secretions.
Pathbase: Pathology Committee
A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells.
mouse_pathology.ontology
MPATH:548
papillary transitional cell carcinoma
A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells.
Book: Kunze; E. (1994) Preneoplastic and neoplastic lesions of the Rat urinary bladder. In; Pathology of Neoplasia and Preneoplasia in Rodents. Eds. Bannach; P.; and Goessner; W.; Vol 1 p 114. Schattauer; Stuttgart New York
Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma).
mouse_pathology.ontology
MPATH:549
carcinoma
Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma).
Pathbase: Curation
Developmental and structural abnormalities occurring during embryonic development or during adult life.
mouse_pathology.ontology
MPATH:55
developmental and structural abnormality
Developmental and structural abnormalities occurring during embryonic development or during adult life.
Pathbase: Pathology Committee
A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
mouse_pathology.ontology
MPATH:550
sarcoma
true
A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
Pathbase: Pathology Committee
A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
mouse_pathology.ontology
MPATH:551
sarcoma
A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
Pathbase: Curation
Benign tumor of the Clara cells of the bronchioalveolar epithelium.
URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
mouse_pathology.ontology
MPATH:552
Merged with MPATH:272 following recommendations of MMHC 2003.
Clara cell adenoma
true
Benign tumor of the Clara cells of the bronchioalveolar epithelium.
Book: Hahn; F.F. and Boorman; GA. neoplasia and pre-neoplasia in the lung. In Pathology of Neoplasia and Preneoplasia in Rodents. Vol.2. p 39. (1997) Schattauer ( Stuttgart and New York)
Inflammation of a nerve.
mouse_pathology.ontology
MPATH:553
neuritis
Inflammation of a nerve.
ISBN:0781727286
Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ.
mouse_pathology.ontology
MPATH:554
Most often used for diseases in which a structure does not develop properly (not necessarily in an embryonic context) and undergoes degradation.
dystrophy
Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ.
Pathbase: Pathology Committee
Deposition of any homogeneous inorganic material.
mouse_pathology.ontology
MPATH:555
mineralisation
Deposition of any homogeneous inorganic material.
ISBN:0781727286
Lesions which in some cases have the potential to become progressively growing malignant tumors.
mouse_pathology.ontology
MPATH:556
potentially cancerous lesions
Lesions which in some cases have the potential to become progressively growing malignant tumors.
Pathbase: Pathology Committee
Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis.
mouse_pathology.ontology
ACF
MPATH:557
Use IEN1 MPATH:130 instead. Suppressed as not strictly a histological diagnosis.
aberrant crypt foci
true
Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis.
PMID:12612914
ACF
Pathbase: Curation
Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0).
mouse_pathology.ontology
MPATH:558
adenomyoepithelioma
Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0).
PMID:10713680
Tumor composed of small glandular clusters with small lumens.
mouse_pathology.ontology
MPATH:559
acinar adenocarcinoma
Tumor composed of small glandular clusters with small lumens.
PMID:10713680
Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult.
mouse_pathology.ontology
MPATH:56
developmental or adult structural defect
Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult.
Pathbase: Pathology Committee
Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces.
mouse_pathology.ontology
MPATH:560
cribriform adenocarcinoma
Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces.
PMID:10713680
Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3.
mouse_pathology.ontology
MPATH:561
adenosquamous carcinoma
Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3.
PMID:12612914
The twisting of a bodily organ or part on its own axis.
mouse_pathology.ontology
MPATH:562
torsion
The twisting of a bodily organ or part on its own axis.
Pathbase: Pathology Committee
carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3).
mouse_pathology.ontology
mucinous adenocarcinoma
MPATH:563
mucinous carcinoma
carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3).
PMID:12612914
mucinous adenocarcinoma
Pathbase: Curation
Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3).
mouse_pathology.ontology
glioblastoma multiforme
monstrocytoma
MPATH:564
Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
glioblastoma
Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3).
ISBN-13:9783794515530
glioblastoma multiforme
Pathbase: Curation
monstrocytoma
Pathbase: Curation
Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium.
mouse_pathology.ontology
MPATH:565
tumors of neurepithelial tissue
Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium.
Pathbase: Pathology Committee
tumors of the meninges
mouse_pathology.ontology
MPATH:566
tumors of the meninges
tumors of the meninges
Pathbase: Curation
Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1).
mouse_pathology.ontology
cystic cerebellar astrocytoma
MPATH:567
Often cystic in children and generally considered benign.
pilocytic astrocytoma
Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1).
Nervous System. Radovsky A and Mahler; J.S. In: Maronpot; R. Pathology of the Mouse. (1999) Cache River Press. Vienna IL
cystic cerebellar astrocytoma
Pathbase: Curation
Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3).
mouse_pathology.ontology
MPATH:568
Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.
mixed glioma
Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3).
ISBN-13:9783794515530
granular cell tumor
mouse_pathology.ontology
MPATH:569
Subsumed into MP:413 as incidence in meninges, whilst a characteristic lesion, is the same type of tumor as that originally classified under myomatous tumors. Describe meningeal granular cell tumor using MP:413 and the anatomical descriptor.
granular cell tumor
true
granular cell tumor
ISBN-13:9783794515530
Failure of a tissue or organ to develop.
mouse_pathology.ontology
Agenesia
MPATH:57
agenesis
Failure of a tissue or organ to develop.
Pathbase: Pathology Committee
Agenesia
Pathbase: Curation
Tumors of the peripheral nervous system.
mouse_pathology.ontology
MPATH:570
peripheral nervous system tumors
Tumors of the peripheral nervous system.
Pathbase: Pathology Committee
Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common.
mouse_pathology.ontology
MPATH:571
pilomatricoma
Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common.
See: Gat; U.; DasGupta; R.; Degenstein; L. and Fuchs; E. (1998) De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin Cell; 95; 605-614.
Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts.
mouse_pathology.ontology
MPATH:572
ossifying fibroma
Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts.
Book: Luz A; Goessner; W.;and Murray AB.(1991) Ossifying fibroma; mouse. In; Jones TC; Mohr U; Hunt RD (eds) Monographs on pathology of laboratory animals. Cardiovascular and musculoskeletal systems. Springer; Berlin Heidelberg New York Tokyo; pp 228-232
Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface.
mouse_pathology.ontology
MPATH:573
inverted transitional cell papilloma
Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface.
Pathbase: Curation
Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests.
mouse_pathology.ontology
MPATH:574
nephroblastomatosis
Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests.
PMID:8383276
This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation.
mouse_pathology.ontology
MPATH:575
basaloid follicular neoplasms
This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation.
URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models
Basaloid neoplasm with numerous mature hair follicles and hair formation.
mouse_pathology.ontology
MPATH:576
trichofolliculoma
Basaloid neoplasm with numerous mature hair follicles and hair formation.
URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models
Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular.
mouse_pathology.ontology
MPATH:577
spiradenoma
Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular.
URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification
Basaloid neoplasm with frequent primitive hair follicles.
mouse_pathology.ontology
MPATH:578
trichoblastoma
Basaloid neoplasm with frequent primitive hair follicles.
URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification
Loss of epithelium and the basement membrane (full thickness). Cf Erosion.
mouse_pathology.ontology
MPATH:579
ulcer
Loss of epithelium and the basement membrane (full thickness). Cf Erosion.
Pathbase: Pathology Committee
Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely.
mouse_pathology.ontology
MPATH:58
aplasia
Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely.
ISBN:0781727286
Partial epithelial denudation not penetrating to the basement membrane.
mouse_pathology.ontology
MPATH:580
erosion
Partial epithelial denudation not penetrating to the basement membrane.
Pathbase: Pathology Committee
Connective tissue proliferative reaction induced by a neoplastic process.
mouse_pathology.ontology
scirrhous
sclerosis
MPATH:581
desmoplasia
Connective tissue proliferative reaction induced by a neoplastic process.
Pathbase: Pathology Committee
scirrhous
Pathbase: Curation
sclerosis
Pathbase: Curation
Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals.
mouse_pathology.ontology
MPATH:582
cicatricial alopecia
Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals.
Pathbase: Curation
Loss of hair follicles in a diffuse dermal scar.
mouse_pathology.ontology
MPATH:583
scarring alopecia
Loss of hair follicles in a diffuse dermal scar.
Pathbase: Pathology Committee
In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia.
mouse_pathology.ontology
MPATH:584
myelofibrosis
In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia.
Pathbase: Pathology Committee
A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals.
mouse_pathology.ontology
MPATH:585
Crystals and acidophilic material have been reported as various materials including Ym1 and Ym2 proteins and blood pigment derivatives and Eotaxin.
acidophilic macrophage pneumonia
A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals.
:Murray AB; Luz A ( 1990 ) Acidophilic macrophage pneumonia in laboratory mice. Vet Pathol. 27; 274-81
A group of degenerative disorders resulting in multiple cysts in tissues.
mouse_pathology.ontology
polycystic kidney disease
polycystic liver disease
polycystic ovary
MPATH:586
polycystic disease
A group of degenerative disorders resulting in multiple cysts in tissues.
Pathbase: Pathology Committee
polycystic kidney disease
Pathbase: Curation
polycystic liver disease
Pathbase: Curation
polycystic ovary
Pathbase: Curation
The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change.
mouse_pathology.ontology
MPATH:587
Cribriform epididymal hyperplasia was initially described as an incidental finding in human orchidectomy specimens. Recently, this condition was also described in mice, homozygous for a targeted mutation in p53.
Cribriform epididymal hyperplasia
The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change.
Journal: La Perle KM; Blomme EA; Sagartz JE; Capen CC (2002) Epididymal cribriform hyperplasia with nuclear atypia in p53 homozygous knockout. Comp Med. 2002 52:568-71.
Dysplasia
mouse_pathology.ontology
MPATH:588
dysplasia
true
Dysplasia
Pathbase: Pathology Committee
Distortion or deficiency of the tissue or cellular architecture.
mouse_pathology.ontology
MPATH:589
Note that with respect to developmental processes the term dysplasia is often used with greater specificity to describe aberrant developmental processes of proliferation and differentation, in which case MPATH: 64 Developmental dysplasia should be used.
dysplasia
Distortion or deficiency of the tissue or cellular architecture.
Pathbase: Pathology Committee
Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts.
mouse_pathology.ontology
MPATH:59
defective branching morphogenesis
Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts.
Pathbase: Pathology Committee
Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts.
mouse_pathology.ontology
fibrous dysplasia
fibrous osteodystrophy
osteodysplasia
osteodystrophy
osteofibrosis
MPATH:590
The benign fibro-osseous lesions (BFOL) represent a clinically diverse group of disorders of bone that share similar histopathologic features. As a group, they are relatively common in the craniofacial complex, especially the jaws. Common in some inbred strains notably B6C3F1 females. Note that many of the synonyms have been used historically and may not be accurate. See: Albassam MA, Courtney CL (1996) Nonneoplastic and neoplastic lesions of the bone. In: Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM (eds) Pathobiology of the aging mouse. Vol 2. Musculoskeletal system. ILSI Press, Washington D.C., pp 425-437. AND Albassam MA, Wojcinski ZW, Barsoum NJ, Smith, GS (1991) Spontaneous fibro-osseous proliferative lesions in the sternums and femurs of B6C3F1 mice. Vet Path 28: 381-388.
fibro-osseous lesion
Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts.
Book: Albassam MA; Courtney CL (1996) Nonneoplastic and neoplastic lesions of the bone. In; Mohr U; Dungworth DL; Capen CC; Carlton WW; Sundberg JP; Ward JM (eds) Pathobiology of the aging mouse. Vol 2. Musculoskeletal system. ILSI Press; Washington D.C.; pp 425-437
fibrous dysplasia
Pathbase: Curation
fibrous osteodystrophy
Pathbase: Curation
osteodysplasia
Pathbase: Curation
osteodystrophy
Pathbase: Curation
osteofibrosis
Pathbase: Curation
Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage.
mouse_pathology.ontology
MPATH:591
fatty infiltration
Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage.
Pathbase: Pathology Committee
Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness.
mouse_pathology.ontology
Albers-Schoenberg disease
marble bone disease
marble bones
MPATH:592
osteopetrosis
Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness.
PMID:15625335
Albers-Schoenberg disease
Pathbase: Curation
marble bone disease
Pathbase: Curation
marble bones
Pathbase: Curation
Plasma cell myeloma - (ICD-O 9732/3).
mouse_pathology.ontology
MPATH:593
myeloma
true
Plasma cell myeloma - (ICD-O 9732/3).
Pathbase: Pathology Committee
Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium.
mouse_pathology.ontology
MPATH:594
cystic hyperplasia
Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium.
Pathbase: Pathology Committee
The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors.
mouse_pathology.ontology
MPATH:595
Production of blood cells in tissues other than the bone marrow. In the mouse, this is usually the liver.
extramedullary hemopoiesis
The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors.
:Ward; J.M.; Mann; P.C.; Mrishima; H.; and Frith; C.H. Thymus; Spleen and Lymph nodes. Ch 13. p342. In Maronpot; R. Pathology of the Mouse. (1999) Cache River Press. Vienna IL
The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion.
mouse_pathology.ontology
MPATH:596
pathological process
The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion.
Pathbase: Pathology Committee
Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology.
mouse_pathology.ontology
MPATH:597
cell and tissue damage process
Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology.
Pathbase: Pathology Committee
degenerative entity
mouse_pathology.ontology
MPATH:598
degenerative entity
true
degenerative entity
Pathbase: Pathology Committee
developmental process abnormalities
mouse_pathology.ontology
MPATH:599
developmental process abnormalities
developmental process abnormalities
Pathbase: Pathology Committee
Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency.
mouse_pathology.ontology
MPATH:6
caseous necrosis
Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency.
ISBN:0781727286
Failure of two cavities, voids or lumens to connect.
mouse_pathology.ontology
MPATH:60
communication defect
Failure of two cavities, voids or lumens to connect.
Pathbase: Curation
Aberrant branch or branching pattern of a branched structure such as the bronchus.
mouse_pathology.ontology
MPATH:600
branching defect
Aberrant branch or branching pattern of a branched structure such as the bronchus.
Pathbase: Curation
Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation.
mouse_pathology.ontology
MPATH:601
developmental hypertrophy
Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation.
Pathbase: Pathology Committee
An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation.
mouse_pathology.ontology
MPATH:602
hyperplastic tissue
An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation.
Pathbase: Pathology Committee
Anatomically located instance of pathological response or entity.
mouse_pathology.ontology
MPATH:603
pathological anatomical entity
Anatomically located instance of pathological response or entity.
Pathbase: Pathology Committee
Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells.
mouse_pathology.ontology
MPATH:604
Excludes abnormalities of developmental proliferation and differentiation.
defective growth and differentiation process
Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells.
Pathbase: Pathology Committee
A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind.
mouse_pathology.ontology
MPATH:605
Nearly exclusively used in an adult context.
metaplastic tissue
A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind.
Pathbase: Pathology Committee
The pathological process that results in the formation and growth of a neoplasm.
mouse_pathology.ontology
neoplastic process
MPATH:606
Literally: new growth of cells. Neoplasia refers to the unscheduled or abnormal growth of cells, potentially resulting in a benign or malignant tumour. Neoplasms include potentially cancerous lesions as well as full malignancies but not all neoplasms are potentially cancerous.
neoplasia
The pathological process that results in the formation and growth of a neoplasm.
Pathbase: Pathology Committee
neoplastic process
Pathbase: Curation
Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage.
mouse_pathology.ontology
MPATH:607
healing and repair structure
Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage.
Pathbase: Pathology Committee
A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
mouse_pathology.ontology
MPATH:608
Generally occur following damage or infection with subsequent inflammatory response. Result of the body`s defensive reaction to foreign material.
abscess
A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
ISBN:0781727286
Pus in a body cavity; when used without qualification, refers specifically to pyothorax.
mouse_pathology.ontology
MPATH:609
empyema
Pus in a body cavity; when used without qualification, refers specifically to pyothorax.
ISBN:0781727286
Inappropriate curvature of a structure.
mouse_pathology.ontology
MPATH:61
curvature defect
Inappropriate curvature of a structure.
Pathbase: Curation
Dilatation of a blood vessel or valve.
mouse_pathology.ontology
MPATH:610
angiectasia
Dilatation of a blood vessel or valve.
ISBN:0781727286
Acute or chronic inflammation of the tongue.
mouse_pathology.ontology
MPATH:611
glossitis
Acute or chronic inflammation of the tongue.
Pathbase: Pathology Committee
A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
mouse_pathology.ontology
MPATH:612
Alternately a cavity formed by liquefactive necrosis within solid tissue. Obsoleted by MPATH 608
Abscess
true
A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
ISBN:0781727286
Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment.
mouse_pathology.ontology
MPATH:613
pigmentation
Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment.
ISBN:0781727286
Solid material formed by aggregation of discrete units or particles.
mouse_pathology.ontology
MPATH:614
concretion
Solid material formed by aggregation of discrete units or particles.
ISBN:0781727286
A disease of the heart muscle or myocardium proper.
mouse_pathology.ontology
MPATH:615
Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
cardiomyopathy
A disease of the heart muscle or myocardium proper.
:NCI Thesaurus / A7567983
Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions.
mouse_pathology.ontology
osteosclerosis
MPATH:616
hyperostosis
Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions.
Long; P.H.; and Leininger; J.R ( 1999) Bones Joints and synovia; p663. in: Pathology of the Mouse. Ed Maronpot; R. Cache River Press
osteosclerosis
Pathbase: Curation
Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type.
mouse_pathology.ontology
Areas of cellular alteration
Enzyme altered focus
Focus of altered hepatocytes (fah)
Hyperplastic focus
Phenotypically altered focus
Preneoplastic focus
MPATH:617
More recently amphophilic cell foci, diffusely basophilic cell foci and vacuolated cell foci have been described.
focus of cellular alteration
Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type.
Pathbase: Mohr
Areas of cellular alteration
Pathbase: Curation
Enzyme altered focus
Pathbase: Curation
Focus of altered hepatocytes (fah)
Pathbase: Curation
Hyperplastic focus
Pathbase: Curation
Phenotypically altered focus
Pathbase: Curation
Preneoplastic focus
Pathbase: Curation
Hyperplasia of myeloid lineage, usually in the spleen.
mouse_pathology.ontology
MPATH:618
Myeloid hyperplasia ia a common diagnosis in mouse spleen. In the normal mouse spleen, a low degree of production of myeloid cells occurs (neutrophils, erythroid cells and megakaryocytes). Commonly in aging mice, due to tumors and inflammatory lesions, the mouse myeloid system in bone marrow and spleen react and become hyperplastic. In the spleen it is diagnosed as "myeloid hyperplasia" (MH), in the past it was often extramedullary hematopoiesis, which is still used by some but it is normal to a low degree in normal mouse spleen.
myeloid hyperplasia
Hyperplasia of myeloid lineage, usually in the spleen.
Pathbase: Pathology Committee
Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus.
mouse_pathology.ontology
MPATH:619
truncoconal septal defect
Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus.
Pathbase: Pathology Committee
Formation of an epithelium bounded cavity not associated with neoplasia.
mouse_pathology.ontology
MPATH:62
cyst
Formation of an epithelium bounded cavity not associated with neoplasia.
Pathbase: Pathology Committee
Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum.
mouse_pathology.ontology
MPATH:620
inter-atrial septal defect
Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum.
Pathbase: Curation
Failure of the inter-ventricular septum to completely close between the left and right ventricles.
mouse_pathology.ontology
MPATH:621
inter-ventricular septal defect
Failure of the inter-ventricular septum to completely close between the left and right ventricles.
Pathbase: Curation
Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells.
lipidosis
mouse_pathology.ontology
adipose degeneration
fatty change
fatty degeneration
MPATH:622
Most commonly associated with degenerative change in the liver.
steatosis
Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells.
Pathbase: Curation
adipose degeneration
Pathbase: Curation
fatty change
Pathbase: Curation
fatty degeneration
Pathbase: Curation
An adhesion, usually between the iris and the cornea or the lens capsule.
mouse_pathology.ontology
MPATH:623
May also be seen in the uterus ( in humans Asherman`s syndrome).
synechia
An adhesion, usually between the iris and the cornea or the lens capsule.
Millodot; Michel and Daniel Laby. Dictionary of Ophthalmology. London: Butterworth Heinemann; 2002
Turning in of the edges of a structure.
mouse_pathology.ontology
MPATH:624
Not return of an enlarged organ to its normal size.
involution
Turning in of the edges of a structure.
ISBN:0781727286
Tearing away or separation of two structures or parts.
mouse_pathology.ontology
MPATH:625
avulsion
Tearing away or separation of two structures or parts.
ISBN:0781727286
To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice.
mouse_pathology.ontology
MPATH:626
prolapse
To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice.
ISBN:0781727286
An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells.
mouse_pathology.ontology
MPATH:627
pyogranulomatous inflammation
An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells.
Pathbase: Pathology Committee
A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion.
mouse_pathology.ontology
lobular capillary hemangioma
MPATH:628
pyogenic granuloma
A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion.
Mills; S.E.; Cooper; P.H. & Fechner; R.E. (1980). Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes. Am J Surg Pathol; 4; 470-9.
lobular capillary hemangioma
Pathbase: Curation
Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution.
mouse_pathology.ontology
MPATH:629
cavernous hemangioma
Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution.
ISBN:0781727286
The removal of accumulated fluids or solids.
mouse_pathology.ontology
MPATH:63
depletion
The removal of accumulated fluids or solids.
Pathbase: Pathology Committee
Abnormally increased nuclear size.
mouse_pathology.ontology
MPATH:630
karyomegaly
Abnormally increased nuclear size.
Pathbase: Pathology Committee
Tissue or cells undergoing hypertrophy, MPATH: 159.
mouse_pathology.ontology
MPATH:631
hypertrophic tissue
Tissue or cells undergoing hypertrophy, MPATH: 159.
Pathbase: Pathology Committee
Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume.
PMID:7943185
Hepatocellular hypertrophy.
mouse_pathology.ontology
MPATH:632
Hepatocytomegaly is an enlargement of the hepatocytes and is generally classified into three types: hepatocellular hypertrophy, megalocytosis, and hepatocellular vacuolation. Hepatocellular hypertrophy is an enlargement of cellular diameter without accompanying nuclear changes, leading to a net gain in the dry mass of the liver. Megalocytosis is characterized by enlargement of both the cell and the nucleus, and hepatocellular vacuolation is characterized by vacuolation, or formation of pockets of fluid within the hepatocytes.
hepatocytomegaly
Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume.
Journal: Ward; J.M.; Anver; M.R.; Haines; D.C. & Benveniste; R.E. (1994). Chronic active hepatitis in mice caused by Helicobacter hepaticus. Am J Pathol; 145; 959-68.
Presence of concretions in the gallbladder or bile ducts.
mouse_pathology.ontology
MPATH:633
cholelithiasis
Presence of concretions in the gallbladder or bile ducts.
ISBN:0781727286
Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`.
mouse_pathology.ontology
Boil
MPATH:634
furunculosis
Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`.
ISBN:9780702027888
Boil
Pathbase: Curation
Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia.
mouse_pathology.ontology
MPATH:635
hydronephrosis
Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia.
ISBN:9780702027888
Inflammation of fatty tissue.
mouse_pathology.ontology
MPATH:636
steatitis
Inflammation of fatty tissue.
Pathbase: Pathology Committee
A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa.
mouse_pathology.ontology
MPATH:637
bursal cyst
A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa.
Pathbase: Pathology Committee
An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation.
mouse_pathology.ontology
MPATH:638
It is usually caused by infection of an operative or traumatic wound, burn or other cutaneous lesion by various bacteria, but group A streptococci and Staphylococcus aureus are the most common aetiological agents.
cellulitis
An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation.
URL:http://cancerweb.ncl.ac.uk/cgi-bin/omd?action=Search+OMD&query=cellulitis
Accumulation of water in the ventricles of the brain.
mouse_pathology.ontology
MPATH:639
hydrocephalus
Accumulation of water in the ventricles of the brain.
Pathbase: Pathology Committee
Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth.
mouse_pathology.ontology
MPATH:64
The word dysplasia as commonly used refers to a precursor state to neoplasia. This is not the context used for this MPATH term.
developmental dysplasia
Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth.
Pathbase: Pathology Committee
Deposition of organic bone matrix.
mouse_pathology.ontology
MPATH:640
osteoid deposition
Deposition of organic bone matrix.
Pathbase: Pathology Committee
Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris.
mouse_pathology.ontology
MPATH:641
epidermal inclusion cyst
Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris.
Pathbase: Curation
Intra or extracellular deposition of cholesterol.
mouse_pathology.ontology
MPATH:642
Often diagnosed morphologically by the presence of cholesterol clefts - bare regions of a section where accumulated cholesterol has been removed by histological processing.
cholesterol deposition
Intra or extracellular deposition of cholesterol.
Pathbase: Curation
Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation.
mouse_pathology.ontology
MPATH:643
serous exudate
Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation.
Pathbase: Pathology Committee
Accumulation of chitinase-like protein.
mouse_pathology.ontology
MPATH:644
crystalloid formation
Accumulation of chitinase-like protein.
Pathbase: Curation
George Gkoutos
2011-03-22T03:09:08Z
mouse_pathology.ontology
MPATH:645
epicarditis
George Gkoutos
2011-03-22T03:12:07Z
mouse_pathology.ontology
MPATH:646
chondroarthritis
George Gkoutos
2011-03-22T03:14:35Z
mouse_pathology.ontology
MPATH:647
interstitial nephritis
George Gkoutos
2011-03-22T03:16:02Z
mouse_pathology.ontology
MPATH:648
interstitial pancreatitis
George Gkoutos
2011-03-22T03:16:36Z
mouse_pathology.ontology
MPATH:649
otitis media
Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development.
mouse_pathology.ontology
MPATH:65
developmental hypoplasia
true
Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development.
Pathbase: Pathology Committee
George Gkoutos
2011-03-22T03:17:25Z
mouse_pathology.ontology
MPATH:650
proliferative dermatitis
George Gkoutos
2011-03-22T03:18:00Z
mouse_pathology.ontology
MPATH:651
ventral glossitis
Benign proliferation of histiocytes.
George Gkoutos
2011-03-22T03:19:47Z
MPATH:146
mouse_pathology.ontology
MPATH:652
histiocytosis
Benign proliferation of histiocytes.
MPATH:curation
George Gkoutos
2011-03-22T03:20:12Z
histiocytosis X
mouse_pathology.ontology
MPATH:653
langerhans cell histiocytosis
George Gkoutos
2011-03-22T03:20:52Z
hemophagocytic syndrome
mouse_pathology.ontology
MPATH:654
non-Langerhans cell histiocytosis
George Gkoutos
2011-03-22T03:36:05Z
mouse_pathology.ontology
MPATH:655
lingual adenitis
Rupture or disruption of erythrocytes with release of contents.
Paul
2011-04-01T12:08:29Z
mouse_pathology.ontology
MPATH:656
May be immune-mediated, induced by infectious organisms, or intrinsic disturbance of cell physiology or membrane/cytoskeletal integrity.
hemolysis
Rupture or disruption of erythrocytes with release of contents.
MPATH:Curation
George Gkoutos
2011-03-22T03:45:17Z
mouse_pathology.ontology
MPATH:657
rhinitis
George Gkoutos
2011-03-22T03:45:36Z
mouse_pathology.ontology
MPATH:658
foreign body rhinitis
George Gkoutos
2011-03-22T03:46:02Z
mouse_pathology.ontology
MPATH:659
foreign body dermatitis
Increase in the diameter of an orifice or tubular structure beyond its normal dimensions.
mouse_pathology.ontology
MPATH:66
dilatation
Increase in the diameter of an orifice or tubular structure beyond its normal dimensions.
Pathbase: Pathology Committee
George Gkoutos
2011-03-22T03:46:42Z
mouse_pathology.ontology
MPATH:660
gastritis
George Gkoutos
2011-03-22T03:47:05Z
mouse_pathology.ontology
MPATH:661
foreign body gastritis
George Gkoutos
2011-03-22T03:47:40Z
mouse_pathology.ontology
MPATH:662
foreign body glossitis
George Gkoutos
2011-03-22T03:48:33Z
mouse_pathology.ontology
MPATH:663
peritonitis
George Gkoutos
2011-03-22T03:48:51Z
mouse_pathology.ontology
MPATH:664
granulomatous peritonitis
George Gkoutos
2011-03-22T03:49:26Z
mouse_pathology.ontology
MPATH:665
foreign body granulomatous peritonitis
George Gkoutos
2011-03-22T03:50:05Z
mouse_pathology.ontology
MPATH:666
periodontitis
George Gkoutos
2011-03-22T03:50:24Z
mouse_pathology.ontology
MPATH:667
foreign body periodontitis
George Gkoutos
2011-03-22T03:51:20Z
mouse_pathology.ontology
MPATH:668
tracheitis
George Gkoutos
2011-03-22T03:52:00Z
mouse_pathology.ontology
MPATH:669
foreign body tracheitis
Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue.
mouse_pathology.ontology
MPATH:67
displacement and deformity
Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue.
Pathbase: Pathology Committee
A mixed inflammatory cell infiltrate, primarily macrophages and some syncitial cells, around the heart attached to the epicardium.
George Gkoutos
2011-03-22T03:52:48Z
mouse_pathology.ontology
MPATH:670
granulomatous epicarditis
A mixed inflammatory cell infiltrate, primarily macrophages and some syncitial cells, around the heart attached to the epicardium.
MPATH:Sundberg
George Gkoutos
2011-02-19T04:01:58Z
mouse_pathology.ontology
MPATH:671
mastitis
George Gkoutos
2011-02-19T04:05:08Z
Urticaria pigmentosa
mouse_pathology.ontology
MPATH:672
mastocytosis
George Gkoutos
2011-02-19T04:06:30Z
mouse_pathology.ontology
MPATH:673
metritis
George Gkoutos
2011-02-19T04:08:00Z
mouse_pathology.ontology
MPATH:674
osteomyelitis
George Gkoutos
2011-02-19T04:09:12Z
mouse_pathology.ontology
MPATH:675
psoriasiform dermatitis
George Gkoutos
2011-02-19T04:10:14Z
mouse_pathology.ontology
MPATH:676
nephritis
George Gkoutos
2011-02-19T04:10:51Z
mouse_pathology.ontology
MPATH:677
pyelonephritis
George Gkoutos
2011-02-19T04:12:09Z
mouse_pathology.ontology
MPATH:678
septic nephritis
George Gkoutos
2011-02-19T04:12:43Z
mouse_pathology.ontology
MPATH:679
urocystitis
A blind ended outpouching through the wall of a tubular organ or bounded cavity.
mouse_pathology.ontology
MPATH:68
diverticulum
A blind ended outpouching through the wall of a tubular organ or bounded cavity.
Pathbase: Curation
George Gkoutos
2011-02-19T04:13:07Z
mouse_pathology.ontology
MPATH:680
septic urocystitis
George Gkoutos
2011-02-19T04:13:38Z
mouse_pathology.ontology
MPATH:681
septicemia
George Gkoutos
2011-02-19T04:15:16Z
mouse_pathology.ontology
MPATH:682
arteritis
George Gkoutos
2011-02-19T04:16:05Z
mouse_pathology.ontology
MPATH:683
degenerative arthritis
George Gkoutos
2011-02-19T04:17:26Z
mouse_pathology.ontology
MPATH:684
arthropathy
George Gkoutos
2011-02-19T04:26:34Z
mouse_pathology.ontology
MPATH:685
accessory organ
George Gkoutos
2011-02-19T04:30:20Z
mouse_pathology.ontology
MPATH:686
amputation
George Gkoutos
2011-02-19T04:30:41Z
mouse_pathology.ontology
MPATH:687
autoamputation
George Gkoutos
2011-02-19T04:34:31Z
mouse_pathology.ontology
MPATH:688
aortitis
George Gkoutos
2011-02-19T04:35:13Z
mouse_pathology.ontology
MPATH:689
lymphangitis
ectopia
mouse_pathology.ontology
MPATH:69
obsolete - Subsumed into heterotopia MPATH:76
ectopia
true
ectopia
Pathbase: Curation
George Gkoutos
2011-02-19T04:36:16Z
mouse_pathology.ontology
MPATH:690
phlebitis
George Gkoutos
2011-02-19T04:45:08Z
cutaneous abscess
mouse_pathology.ontology
MPATH:691
pustule
George Gkoutos
2011-02-19T04:56:39Z
mouse_pathology.ontology
MPATH:692
ulcerative blepharitis
George Gkoutos
2011-02-19T05:02:23Z
mouse_pathology.ontology
MPATH:693
pyometra
George Gkoutos
2011-02-19T05:05:05Z
mouse_pathology.ontology
MPATH:694
acidophilic anterior pituitary gland adenoma
George Gkoutos
2011-02-19T05:12:17Z
mouse_pathology.ontology
MPATH:695
spindle cell sarcoma
George Gkoutos
2011-02-19T05:13:13Z
mouse_pathology.ontology
MPATH:696
spindle cell hyperplasia
George Gkoutos
2011-02-19T05:17:30Z
mouse_pathology.ontology
MPATH:697
alopecia areata
George Gkoutos
2011-02-19T05:23:34Z
mouse_pathology.ontology
osteophytes
MPATH:698
exostosis
George Gkoutos
2011-02-19T05:24:05Z
mouse_pathology.ontology
MPATH:699
ankylosing exostosis
A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists.
mouse_pathology.ontology
MPATH:7
coagulation necrosis
A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists.
ISBN:0781727286
An abnormal passage between two internal organs or leading from a cavity to the body surface.
mouse_pathology.ontology
MPATH:70
fistula
An abnormal passage between two internal organs or leading from a cavity to the body surface.
Pathbase: Curation
George Gkoutos
2011-02-19T05:24:55Z
mouse_pathology.ontology
MPATH:700
ascites
George Gkoutos
2011-02-19T05:29:50Z
mouse_pathology.ontology
MPATH:701
developmental aspermia
George Gkoutos
2011-02-19T05:30:40Z
mouse_pathology.ontology
MPATH:702
acquired aspermia
George Gkoutos
2011-02-19T05:31:21Z
mouse_pathology.ontology
MPATH:703
developmental hypoplasia
George Gkoutos
2011-02-19T08:28:41Z
mouse_pathology.ontology
MPATH:704
thyroiditis
George Gkoutos
2011-02-19T10:33:51Z
mouse_pathology.ontology
MPATH:705
acinar atrophy
George Gkoutos
2011-02-19T10:37:34Z
mouse_pathology.ontology
MPATH:706
cryptorchidism
George Gkoutos
2011-02-20T08:44:41Z
mouse_pathology.ontology
MPATH:707
angiolipoma
Distension of the renal pelvis by accumulated fluid or urine.
Paul
2011-06-06T03:01:54Z
mouse_pathology.ontology
MPATH:708
May be fetal or adult.
pyelectasia
Distension of the renal pelvis by accumulated fluid or urine.
:
Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation.
Paul
2011-06-06T03:24:13Z
mouse_pathology.ontology
MPATH:709
alveolar rhabdomyosarcoma
Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation.
ICD-O:8920/3
Failure of two or more structures ( not voids or lumens) to join together.
mouse_pathology.ontology
MPATH:71
fusion process defect
Failure of two or more structures ( not voids or lumens) to join together.
ISBN:0781727286
Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle.
Paul
2011-06-06T03:31:11Z
Myosarcoma
mouse_pathology.ontology
Rhabdopoietic Sarcoma
Sarcoma Botryoides [Soft Tissues]
Embryonal Sarcoma
Malignant Rhabdomyoma
MPATH:710
Includes spindle cell, botryoid, anaplastic.
embryonal rhabdomyosarcoma
Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle.
ICD-O:8910/3
ICDO-:8912/3
George Gkoutos
2011-02-20T12:06:02Z
mouse_pathology.ontology
MPATH:711
situs ambiguus
George Gkoutos
2011-02-20T12:06:38Z
mouse_pathology.ontology
MPATH:712
heterotaxy
George Gkoutos
2011-02-20T12:07:15Z
XX:<new dbxref>
mouse_pathology.ontology
situs inversus with dextrocardia
MPATH:713
situs ambiguus totalis
George Gkoutos
2011-02-20T12:08:14Z
mouse_pathology.ontology
MPATH:714
situs inversus with levocardia
George Gkoutos
2011-02-20T12:10:00Z
mouse_pathology.ontology
MPATH:715
sinusitis
George Gkoutos
2011-02-20T12:14:20Z
mouse_pathology.ontology
primary ciliary dyskinesis
MPATH:716
ciliary motility defect
George Gkoutos
2011-02-20T02:28:51Z
mouse_pathology.ontology
MPATH:717
Most often used in the context of bone.
sequestrum
Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine.
Paul
2011-06-06T03:39:01Z
mouse_pathology.ontology
MPATH:718
pre-sacral teratoma
Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine.
:
George Gkoutos
2011-02-20T12:04:36Z
mouse_pathology.ontology
MPATH:719
bronchiectasia
Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159.
mouse_pathology.ontology
MPATH:72
growth acceleration
Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159.
Pathbase: Pathology Committee
George Gkoutos
2011-02-20T12:05:38Z
mouse_pathology.ontology
MPATH:720
situs inversus
Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx.
Paul
2011-06-06T03:51:12Z
mouse_pathology.ontology
MPATH:721
sacrococcygeal teratoma
Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx.
:
Benign stromal tumors of the soft tissue with skeletal muscle differentiation.
Paul
2011-06-06T03:59:49Z
mouse_pathology.ontology
MPATH:722
Adult and fetal types.
rhabdomyoma
Benign stromal tumors of the soft tissue with skeletal muscle differentiation.
ICD-O:M-8900/0
PMID:3525381
Systemic manifestation of MPATH: 407.
Paul
2011-06-06T04:11:04Z
Desmoid Tumor
mouse_pathology.ontology
Musculoaponeurotic Fibromatosis
Aggressive Fibromatosis
Plantar Fibromatosis (Ledderhose Disease)
MPATH:723
fibromatosis
Systemic manifestation of MPATH: 407.
ICDO:M-8822/1
Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol.
Paul
2011-06-08T03:43:07Z
mouse_pathology.ontology
MPATH:724
xanthoma
Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol.
MPATH:Pathology Committee
Paul
2011-10-26T02:02:02Z
mouse_pathology.ontology
MPATH:725
chronic interstitial nephritis
Paul
2011-10-26T02:05:04Z
mouse_pathology.ontology
MPATH:726
hemosiderosis
Paul
2011-10-26T02:05:29Z
mouse_pathology.ontology
MPATH:727
hepatic hemosiderosis
Paul
2011-10-26T02:06:12Z
mouse_pathology.ontology
MPATH:728
pulmonary hemosiderosis
Paul
2011-10-26T02:06:46Z
mouse_pathology.ontology
MPATH:729
splenic melanosis
The cessation of fetal or embryonic growth beyond a particular stage.
mouse_pathology.ontology
MPATH:73
growth arrest
The cessation of fetal or embryonic growth beyond a particular stage.
Pathbase: Pathology Committee
Paul
2011-10-26T02:13:35Z
mouse_pathology.ontology
MPATH:730
renal tubular concretion
Paul
2011-10-26T02:17:02Z
mouse_pathology.ontology
MPATH:731
Leydig cell hyperplasia
Paul
2011-10-26T02:19:12Z
mouse_pathology.ontology
MPATH:732
tracheal gland ectasia
A uterus distended with a fluid containing large quantities of mucin.
Paul
2011-10-26T02:22:56Z
mouse_pathology.ontology
MPATH:733
mucometra
A uterus distended with a fluid containing large quantities of mucin.
MPATH:Sundberg
Paul
2011-10-26T02:23:54Z
mouse_pathology.ontology
MPATH:734
acute blepharitis
Thickening of the cementum layer of the molars.
Paul
2011-10-26T02:25:55Z
mouse_pathology.ontology
MPATH:735
This is usually a normal adaptive response, serving to improve the functional properties of teeth during aging.
molar hypercementosis
Thickening of the cementum layer of the molars.
MPATH:Sundberg
Paul
2011-10-26T02:29:29Z
mouse_pathology.ontology
MPATH:736
A variety of cysts develop in the ovary. They are subdivided based on where they develop anatomically. Ovarian follicles in this case become large and fluid filled.
ovarian follicular cyst
Paul
2011-10-26T02:33:06Z
mouse_pathology.ontology
MPATH:737
Usually rd6-outer retinal photoreceptor degeneration
retinal degeneration
Paul
2011-10-26T02:34:35Z
mouse_pathology.ontology
MPATH:738
The uterus of older female mice often becomes distended with numerous fluid filled cysts that extend from the endometrium.
uterine cystic endometrial hyperplasia
Extravascular blood between retina and choroid
Paul
2011-10-26T02:36:03Z
mouse_pathology.ontology
MPATH:739
sub-retinal hemorrhage
Extravascular blood between retina and choroid
MPATH:Sundberg
A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477.
mouse_pathology.ontology
MPATH:74
hamartoma
A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477.
ISBN:0781727286
Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium.
Paul
2011-10-26T02:38:14Z
mouse_pathology.ontology
MPATH:740
drusen
Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium.
MPATH:Sundberg
An increase in size of the spleen.
Paul
2011-10-26T02:56:13Z
mouse_pathology.ontology
MPATH:741
splenomegaly
An increase in size of the spleen.
MPATH:Sundberg
Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma.
Paul
2011-10-26T02:59:08Z
mouse_pathology.ontology
MPATH:742
These become more common with age.
intervertebral disk prolapse
Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma.
MPATH:Sundberg
Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins.
Paul
2011-10-26T03:04:08Z
mouse_pathology.ontology
MPATH:743
hepatic centrolobular fatty metamorphosis
Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins.
MPATH:Sundberg
Release of melanin pigment in the dermis.
Paul
2011-10-26T03:06:29Z
mouse_pathology.ontology
MPATH:744
Observed as melanin pigment within macrophages in the dermis. Inflammation in the epidermis stimulates melanocytes to increase the synthesis of melanin and subsequently to transfer the pigment to surrounding keratinocytes. If the basal layer is injured (e.g. lichen planus), melanin pigment is released and subsequently trapped by macrophages in the papillary dermis.
pigmentary incontinence
Release of melanin pigment in the dermis.
MPATH:Sundberg
Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers.
Paul
2011-10-26T03:15:56Z
mouse_pathology.ontology
MPATH:745
zenker's necrosis
Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers.
MPATH:Sundberg
Fragmentation and erosion of articular cartilage.
Paul
2011-10-26T03:18:38Z
mouse_pathology.ontology
MPATH:746
cartilagenous erosion
Fragmentation and erosion of articular cartilage.
MPATH::Sundberg
Pink amorphous material (amyloid) deposited within the renal tubules.
Paul
2011-10-26T03:34:30Z
mouse_pathology.ontology
MPATH:747
renal tubular amyloidosis
Pink amorphous material (amyloid) deposited within the renal tubules.
MPATH:Sundberg
An old organized thrombus that has been recanalized to permit blood flow.
Paul
2011-10-26T03:36:06Z
mouse_pathology.ontology
MPATH:748
recanalised thrombus
An old organized thrombus that has been recanalized to permit blood flow.
MPATH:Sundberg
Various degrees of pulmonary interstitial fibrosis.
Paul
2011-10-26T03:37:48Z
mouse_pathology.ontology
MPATH:749
focal pulmonary fibrosis
Various degrees of pulmonary interstitial fibrosis.
MPATH:Sundberg
Protrusion of a loop or wall of an organ through an abnormal opening.
mouse_pathology.ontology
MPATH:75
hernia
Protrusion of a loop or wall of an organ through an abnormal opening.
Pathbase: Curation
Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes.
Paul
2011-10-26T03:40:09Z
mouse_pathology.ontology
MPATH:750
pulmonary adenomatosis
Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes.
MPATH:Sundberg
Free pigment in anterior chamber/elsewhere in eye.
Paul
2011-10-26T03:41:56Z
mouse_pathology.ontology
MPATH:751
pigment dispersion
Free pigment in anterior chamber/elsewhere in eye.
MPATH:Sundberg
loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other.
Paul
2011-10-26T03:44:05Z
mouse_pathology.ontology
MPATH:752
This is a form of trichotillomania.
barbered
loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other.
MPATH:Sundberg
The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks.
Paul
2011-10-26T03:47:01Z
mouse_pathology.ontology
MPATH:753
gastric forestomach papillomatous hyperplasia
The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks.
MPATH:Sundberg
Spleen contains foci of macrophages containing yellow brown pigment that is positive for iron using Prussian blue.
Paul
2011-11-02T03:30:56Z
mouse_pathology.ontology
MPATH:754
splenic hemosiderosis
Spleen contains foci of macrophages containing yellow brown pigment that is positive for iron using Prussian blue.
MPATH:Sundberg
Small foci of mineralization within the interstitium between alveoli.
Paul
2011-11-02T03:33:11Z
mouse_pathology.ontology
MPATH:755
pulmonary interstitial mineralisation
Small foci of mineralization within the interstitium between alveoli.
MPATH:Sundberg
Chronic inflammation in and around small and medium sized arteries, often in more than one location.
Paul
2011-11-02T03:41:52Z
mouse_pathology.ontology
Kussmaul disease
Kussmaul-Maier disease
MPATH:756
polyarteritis nodosa
Chronic inflammation in and around small and medium sized arteries, often in more than one location.
MPATH:Sundberg
Foci of mineralization within the interstitium of a tissue.
Paul
2011-11-02T03:54:07Z
mouse_pathology.ontology
MPATH:757
interstitial mineralization
Foci of mineralization within the interstitium of a tissue.
MPATH:Sundberg
Small foci of mineralization within the interstitium between tubules.
Paul
2011-11-02T03:57:16Z
mouse_pathology.ontology
MPATH:758
renal interstitial mineralisation
Small foci of mineralization within the interstitium between tubules.
MPATH:Sundberg
Appearance of clinical and/or subclinical signs and symptoms associated with pregnancy when the animal is not pregnant
Paul
2011-11-02T04:02:14Z
XX:<new xref>
false pregnancy
mouse_pathology.ontology
MPATH:759
Virgin females have mammary acini and ducts dilated to various degrees filled with proteinaceous materials suggestive of lactation or involution.
pseudocyesis
Appearance of clinical and/or subclinical signs and symptoms associated with pregnancy when the animal is not pregnant
MPATH:Sundberg
Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly).
mouse_pathology.ontology
Ectopia
MPATH:76
heterotopia
Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly).
Pathbase: Pathology Committee
Ectopia
Pathbase: Curation
Marked dilatation of the ovarian bursa.
Paul
2011-11-02T04:07:28Z
mouse_pathology.ontology
MPATH:760
May compress the ovary
ovarian bursal cyst
Marked dilatation of the ovarian bursa.
MPATH:Sundberg
Linear palisaiding of nuclei within thin pale muscle fibers suggestive of repair.
Paul
2011-11-02T04:14:39Z
mouse_pathology.ontology
MPATH:761
muscle regeneration
Linear palisaiding of nuclei within thin pale muscle fibers suggestive of repair.
MPATH:Sundberg
Thyroid gland follicles are filled with colloid but vary greatly in size.
Paul
2011-11-02T04:18:38Z
mouse_pathology.ontology
MPATH:762
Suggestive of goiter or other functional abnormality.
thyroid follicle pleomorphism
Thyroid gland follicles are filled with colloid but vary greatly in size.
MPATH:Sundberg
Salivary gland duct occlusion resulting in massive enlargement forming a large cyst-like structure.
Paul
2011-11-02T04:23:20Z
mouse_pathology.ontology
MPATH:763
sialocele
Salivary gland duct occlusion resulting in massive enlargement forming a large cyst-like structure.
MPATH:Sundberg
A fracture is the (local) separation of a bone into two, or more, pieces under the action of stress.
Paul
2011-11-02T04:29:57Z
mouse_pathology.ontology
MPATH:764
fracture
A fracture is the (local) separation of a bone into two, or more, pieces under the action of stress.
MPATH:PNS
Break in bone associated with exostoses.
Paul
2011-11-02T04:34:27Z
mouse_pathology.ontology
MPATH:765
fracture and healing
Break in bone associated with exostoses.
MPATH:Sundberg
The lamina propria is distended with amorphous hyalinized material interpreted to be amyloid protein.
Paul
2011-11-02T06:59:37Z
mouse_pathology.ontology
MPATH:766
intestinal amyloidosis
The lamina propria is distended with amorphous hyalinized material interpreted to be amyloid protein.
MPATH:Sundberg
A Meckel's diverticulum is a pouch on the wall of the lower part of the intestine that is present at birth.
Paul
2011-11-02T07:05:54Z
mouse_pathology.ontology
MPATH:767
Meckel's diverticulum
A Meckel's diverticulum is a pouch on the wall of the lower part of the intestine that is present at birth.
PMH:0001281
Necrosis associated with or caused by local bacterial infection.
Paul
2011-11-02T07:11:40Z
mouse_pathology.ontology
MPATH:768
septic necrosis
Necrosis associated with or caused by local bacterial infection.
MPATH:Sundberg
Necrosis of the uterine wall with large bacterial colonies on its surface.
Paul
2011-11-02T07:15:32Z
mouse_pathology.ontology
MPATH:769
uterine septic necrosis
Necrosis of the uterine wall with large bacterial colonies on its surface.
MPATH:Sundberg
Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias.
mouse_pathology.ontology
MPATH:77
homoeotic change
Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias.
Pathbase: Pathology Committee
Abnormal organ dimensions or weight
Paul
2011-11-02T07:19:32Z
mouse_pathology.ontology
MPATH:770
abnormal organ size
Abnormal organ dimensions or weight
MPATH:<new dbxref>
MPATH:PNS
Abnormality of extent of the normal long axis
Paul
2011-11-02T07:21:06Z
mouse_pathology.ontology
MPATH:771
abnormal organ length
Abnormality of extent of the normal long axis
MPATH:<new dbxref>
MPATH:PNS
Abnormal mass of organ
Paul
2011-11-02T07:22:00Z
mouse_pathology.ontology
MPATH:772
abnormal organ mass
Abnormal mass of organ
MPATH:<new dbxref>
MPATH:PNS
Abnormal length of the intestine.
Paul
2011-11-02T07:22:44Z
mouse_pathology.ontology
MPATH:773
abnormal intestine length
Abnormal length of the intestine.
MPATH:PNS
Focal necrosis in the liver often but not always associated with thrombosis.
Paul
2011-11-02T07:24:44Z
mouse_pathology.ontology
MPATH:774
focal hepatic coagulative necrosis
Focal necrosis in the liver often but not always associated with thrombosis.
MPATH:Sundberg
Exertion of abnormal force on a structure or structures usually resulting in deformation and damage.
Paul
2011-11-02T07:27:38Z
mouse_pathology.ontology
MPATH:775
compression
Exertion of abnormal force on a structure or structures usually resulting in deformation and damage.
MPATH:PNS
mpath:<new dbxref>
A spermatocoele is a cyst that contains spermatozoa. .
Paul
2011-11-02T07:30:33Z
mouse_pathology.ontology
MPATH:776
They occur in the head of the epididymis or less commonly, in the spermatic cord.
spermatocoele
A spermatocoele is a cyst that contains spermatozoa. .
MPATH:PNS
Formation of urinary concretions in any part of the kidney.
Paul
2011-11-02T07:32:55Z
mouse_pathology.ontology
MPATH:777
urelithiasis
Formation of urinary concretions in any part of the kidney.
MPATH:PNS
https://doi.org/10.1038/srep41807
Paul
2011-11-02T07:34:59Z
mouse_pathology.ontology
MPATH:778
corpora amylacea
https://doi.org/10.1038/srep41807
MPATH:PNS
Formation or urinary concretions in the ureter.
Paul
2011-11-02T07:36:04Z
mouse_pathology.ontology
MPATH:779
uretolithiasis
Formation or urinary concretions in the ureter.
MPATH:PNS
Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls.
mouse_pathology.ontology
MPATH:78
incomplete closure
Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls.
Pathbase: Pathology Committee
Pseudoxanthoma elasticum is a progressive disorder characterized by accumulated deposits of calcium and other minerals in elastic fibers.
Paul
2011-11-02T07:38:35Z
mouse_pathology.ontology
MPATH:780
pseudoxanthoma elasticum
Pseudoxanthoma elasticum is a progressive disorder characterized by accumulated deposits of calcium and other minerals in elastic fibers.
MPATH:PNS
Softening of brain tissue, usually caused by vascular insufficiency or degenerative changes.
Paul
2011-11-02T07:43:13Z
cerebromalacia
mouse_pathology.ontology
MPATH:781
Areas in the brain where the parenchyma is blanched. Cells in this area are pycnotic. This may be the sequela of an infarction.
encephalomalacia
Softening of brain tissue, usually caused by vascular insufficiency or degenerative changes.
MPATH:PNS
Collapse of the eye globe associated with degenerative changes.
Paul
2011-11-02T07:51:11Z
mouse_pathology.ontology
MPATH:782
phthisis bulbi
Collapse of the eye globe associated with degenerative changes.
MPATH:Sundberg
Follicular dystrophy, rupture, foreign body reaction, ulceration, scarring, pseudoepitheliomatous hyperplasia are part of a syndrome commonly called B6 dermatitis in black strains of mice.
Paul
2011-11-02T07:55:07Z
mouse_pathology.ontology
MPATH:783
B6 dermatitis
Follicular dystrophy, rupture, foreign body reaction, ulceration, scarring, pseudoepitheliomatous hyperplasia are part of a syndrome commonly called B6 dermatitis in black strains of mice.
MPATH:Sundberg
Degeneration and resorption of an ovarian follicle before it reaches maturity and ruptures.
Paul
2011-11-02T07:59:53Z
mouse_pathology.ontology
MPATH:784
Included here to permit annotation of unusual patterns or atresia; abnormal numbers of atretic follicles or abnoral size or distribution.
follicular atresia
Degeneration and resorption of an ovarian follicle before it reaches maturity and ruptures.
MPATH:PNS
Marked production of granulocytes, primarily neutrophils, usually in response to a major acute inflammatory response.
Paul
2011-11-02T08:06:16Z
mouse_pathology.ontology
MPATH:785
bone marrow granulopoiesis
Marked production of granulocytes, primarily neutrophils, usually in response to a major acute inflammatory response.
MPATH:Sundberg
The drying, thickening and coagulation of extracellular secretions or fluids.
Paul
2011-11-02T08:09:33Z
mouse_pathology.ontology
MPATH:786
inspissation
The drying, thickening and coagulation of extracellular secretions or fluids.
MPATH:PNS
Ventral prolapse of the intervertebral disk.
Paul
2011-11-02T08:37:59Z
mouse_pathology.ontology
MPATH:787
Ventral prolapse is quite rare but found in ageing mice.
intervertebral disk prolapse ventral
Ventral prolapse of the intervertebral disk.
MPATH:Sundberg
The testicle twisted around the vascular tract to constrict flow resulting in liquifactive necrosis of the affected testicle.
Paul
2011-11-02T08:43:39Z
mouse_pathology.ontology
MPATH:788
testicular torsion
The testicle twisted around the vascular tract to constrict flow resulting in liquifactive necrosis of the affected testicle.
MPATH:Sundberg
Dermal granuloma surrounding hair fibers.
Paul
2011-11-02T08:52:38Z
mouse_pathology.ontology
MPATH:789
trichogranuloma
Dermal granuloma surrounding hair fibers.
MPATH:Sundberg
Abnormal position or orientation of a structure insufficient to be called a heterotopia.
mouse_pathology.ontology
Misplacement
MPATH:79
malposition
Abnormal position or orientation of a structure insufficient to be called a heterotopia.
Pathbase: Curation
Misplacement
Pathbase: Curation
Retinal degeneration of both eyes.
Paul
2011-11-02T08:56:45Z
mouse_pathology.ontology
MPATH:790
bilateral retinal degeneration
Retinal degeneration of both eyes.
MPATH:Sundberg
Occlusion of a vessel by a piece of dissected cartilage.
Paul
2011-11-02T09:27:08Z
mouse_pathology.ontology
MPATH:791
cartilagenous embolism
Occlusion of a vessel by a piece of dissected cartilage.
MPATH:Sundberg
Proliferation of the reticuloendothelial cells in the medulla of the lymph node.
Paul
2011-11-02T09:32:12Z
mouse_pathology.ontology
MPATH:792
lymph node reticuloendothelial cell hyperplasia
Proliferation of the reticuloendothelial cells in the medulla of the lymph node.
MPATH:Sundberg
An increase in the size of the spleen due to ongoing acute or chronic infection.
Paul
2011-11-02T09:42:26Z
mouse_pathology.ontology
MPATH:793
reactive splenomegaly
An increase in the size of the spleen due to ongoing acute or chronic infection.
MPATH:Sundberg
Digested blood in the lumen of the stomach or small intestine, indicative of hemorrhage.
Paul
2011-11-02T09:57:01Z
mouse_pathology.ontology
MPATH:794
melena
Digested blood in the lumen of the stomach or small intestine, indicative of hemorrhage.
MPATH:Sundberg
Round , often laminar, non-proteinaceous eosinophilic bodies representing calcium deposition.
Paul
2011-11-02T10:01:09Z
mouse_pathology.ontology
MPATH:795
Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from (1) the infarction and calcification of papillae tips and (2) calcification of intralymphatic tumor thrombi.
psammoma body
Round , often laminar, non-proteinaceous eosinophilic bodies representing calcium deposition.
MPATH:Sundberg
Lack of sperm.
Paul
2011-11-02T10:10:45Z
mouse_pathology.ontology
MPATH:796
May be through failure of spermatogenesis, or increased death.
aspermia
Lack of sperm.
MPATH:Sundberg
Compromise or abnormality of the process of spermatogenesis
Paul
2011-11-02T10:17:11Z
mouse_pathology.ontology
MPATH:797
spermatogenesis defect
Compromise or abnormality of the process of spermatogenesis
MPATH:PNS
Reduced numbers of sperm.
Paul
2011-11-02T10:18:26Z
mouse_pathology.ontology
MPATH:798
hypospermia
Reduced numbers of sperm.
MPATH:PNS
scoliosis is an abnormal curvature of the spine. The spine curves away from the middle or sideways.
Paul
2011-11-02T10:20:56Z
mouse_pathology.ontology
MPATH:799
scoliosis
scoliosis is an abnormal curvature of the spine. The spine curves away from the middle or sideways.
MPATH:Sundberg
Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris.
mouse_pathology.ontology
MPATH:8
fat necrosis
Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris.
ISBN:0781727286
Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine.
mouse_pathology.ontology
MPATH:80
obstruction and stenosis
Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine.
Pathbase: Pathology Committee
Dorsal prolapse of the intervertebral disk.
Paul
2011-11-03T07:08:38Z
mouse_pathology.ontology
MPATH:800
intervertebral disk prolapse dorsal
Dorsal prolapse of the intervertebral disk.
MPATH:Sundberg
Presence of dorsal and ventrally prolapsed disks in the same vertebral column.
Paul
2011-11-03T07:09:46Z
mouse_pathology.ontology
MPATH:801
intervertebral disks prolapsed dorsally and ventrally
Presence of dorsal and ventrally prolapsed disks in the same vertebral column.
MPATH:Sundberg
Eversion through the anus.
Paul
2011-11-03T07:11:38Z
mouse_pathology.ontology
MPATH:802
rectal prolapse
Eversion through the anus.
MPATH:Sundberg
Thickening of trabecular bone.
Paul
2011-11-03T07:41:18Z
mouse_pathology.ontology
MPATH:803
Not osteopetrosis.
trabecular bone thickening
Thickening of trabecular bone.
MPATH:Sundberg
Large numbers of thin-walled dilated lymphatic channels situated in the dermis, subcutis or skeletal muscle.
Paul
2011-11-25T03:58:53Z
mouse_pathology.ontology
MPATH:804
This is a developmental malformation
cavernous lymphangioma
Large numbers of thin-walled dilated lymphatic channels situated in the dermis, subcutis or skeletal muscle.
ISBN:0-19-261976-4
Variant of cavernous lymphangioma (MPATH:804) showing gross dilatation of lymphatic channels.
Paul
2011-11-25T04:01:26Z
mouse_pathology.ontology
Cystic lymphangioma.
MPATH:805
cystic hygroma
Variant of cavernous lymphangioma (MPATH:804) showing gross dilatation of lymphatic channels.
ISBN:0-19-261976-4
Cutaneous grouped collection of thin-walled translucent vessels, which appear at birth or in early infancy and are commonest around the limb girdles.
Paul
2011-11-25T04:03:31Z
mouse_pathology.ontology
MPATH:806
Generally believed to represent a developmental defect but may be associated with surgery.
lymphangioma circumscriptum
Cutaneous grouped collection of thin-walled translucent vessels, which appear at birth or in early infancy and are commonest around the limb girdles.
ISBN:0-19-261976-4
Large cystic subcutaneous spaces usually found in the flexures, especially around the neck.
Paul
2011-11-25T04:11:06Z
mouse_pathology.ontology
Cystic hygroma
MPATH:807
Obstruction of the developing lymphatics may contribute to their genesis.
hygroma
Large cystic subcutaneous spaces usually found in the flexures, especially around the neck.
ISBN:0-19-261976-4
Accumulation of interstitial fluid caused by blockage or failure of the lymphatic system.
Paul
2011-11-25T04:15:32Z
Lymphoedema
mouse_pathology.ontology
MPATH:808
Not be confused with edema arising from venous insufficiency, which is not lymphedema.
lymphedema
Accumulation of interstitial fluid caused by blockage or failure of the lymphatic system.
ISBN:0-19-261976-4
Edema of the posterior aspect of the fetal neck caused by an accumulation of fluid, usually lymph.
Paul
2011-11-25T04:33:15Z
mouse_pathology.ontology
MPATH:809
nuchal edema
Edema of the posterior aspect of the fetal neck caused by an accumulation of fluid, usually lymph.
MPATH:Pathology committee
Presence of a hole/channel through a normally imperforate structure often a membrane or septum.
mouse_pathology.ontology
MPATH:81
perforation
Presence of a hole/channel through a normally imperforate structure often a membrane or septum.
Pathbase: Pathology Committee
Degenerative changes in hair follicles resulting in a deformed hair fiber, sometimes root sheath hyperplasia and follicular rupture.
Paul
2011-11-25T05:04:59Z
mouse_pathology.ontology
MPATH:810
follicular dystrophy
Degenerative changes in hair follicles resulting in a deformed hair fiber, sometimes root sheath hyperplasia and follicular rupture.
MPATH:Sundberg
Deposition of minerals in the epicardium.
Paul
2012-03-19T03:53:35Z
mouse_pathology.ontology
MPATH:811
epicardial mineralization
Deposition of minerals in the epicardium.
MPATH:curation
A collection of fluid underneath the top layer of skin (epidermis).
Paul
2012-03-19T03:59:12Z
mouse_pathology.ontology
MPATH:812
Most blisters are filled with a clear fluid called serum or plasma. However, blisters can be filled with blood (known as blood blisters) or with pus (if they become infected).
blister
A collection of fluid underneath the top layer of skin (epidermis).
MPATH:curation
Lesions of a connective tissue disease causing blisters in the skin and mucosal membranes.
Paul
2012-03-19T04:02:20Z
mouse_pathology.ontology
MPATH:813
epidermolysis bullosa lesions
Lesions of a connective tissue disease causing blisters in the skin and mucosal membranes.
MPATH:curation
Locally circumscribed regions of fatty change.
Paul
2012-03-19T04:10:23Z
focal fatty change
mouse_pathology.ontology
MPATH:814
focal hepatic lipidosis
Locally circumscribed regions of fatty change.
MPATH:curation
subtype of steatosis with Hepatocytes containing a large well-defined single rounded vacuole within each cell, nucleus and cytoplasm displaced to the periphery,
Paul
2012-03-19T04:13:31Z
macrovesicular steatosis
mouse_pathology.ontology
MPATH:815
macrovesicular lipidosis
subtype of steatosis with Hepatocytes containing a large well-defined single rounded vacuole within each cell, nucleus and cytoplasm displaced to the periphery,
PMID: 21191096
Variant form of hepatic steatosis. Hepatocytes partially or completely filled with numerous small lipid vacuoles. Affected hepatocytes may have a foamy appearance.Small vacuoles do not normally displace the nucleus to
the periphery in contrast to macrovesicular lipidosis.
Paul
2012-03-19T04:18:42Z
microvesicular fatty change
microvesicular steatosis
mouse_pathology.ontology
MPATH:816
microvesicular lipidosis
Variant form of hepatic steatosis. Hepatocytes partially or completely filled with numerous small lipid vacuoles. Affected hepatocytes may have a foamy appearance.Small vacuoles do not normally displace the nucleus to
the periphery in contrast to macrovesicular lipidosis.
PMID:21191096
Form of degenerative process in which there is Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity.
Paul
2012-03-19T04:26:38Z
cloudy swelling
hydropic change
mouse_pathology.ontology
<new synonym>
MPATH:817
Cytoplasmic vacuolation and ballooning with a centrally located nucleus.
hydropic degeneration
Form of degenerative process in which there is Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity.
MPATH:curation
Paul
2012-03-19T04:37:02Z
mouse_pathology.ontology
MPATH:818
focal pulmonary histiocytosis
Paul
2012-03-19T04:39:04Z
mouse_pathology.ontology
MPATH:819
focal renal pelvic mineralisation.
Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly).
mouse_pathology.ontology
Embryonic rest.
MPATH:82
persistent embryonic structure
Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly).
Pathbase: Pathology Committee
Embryonic rest.
Pathbase: Curation
Increase in size of the thyroid gland caused initially by uniform follicular epithelial hyperplasia generally in response to iodine deficiency.
Paul
2012-03-19T05:09:58Z
goiter
mouse_pathology.ontology
hyperplastic goitre
MPATH:820
goitre
Increase in size of the thyroid gland caused initially by uniform follicular epithelial hyperplasia generally in response to iodine deficiency.
MPATH:curation
Tissue showing smaller mass as a consequence of deficient proliferation or premature differentiation.
Paul
2012-03-19T05:20:21Z
mouse_pathology.ontology
MPATH:821
hypoplastic tissue
Tissue showing smaller mass as a consequence of deficient proliferation or premature differentiation.
MPATH:curation
Reduced mass of GALT resulting form fewer cells.
Paul
2012-03-19T05:21:50Z
mouse_pathology.ontology
MPATH:822
hypoplastic gut associated lymphoid tissue
Reduced mass of GALT resulting form fewer cells.
MPATH:curation
A benign neoplasm characterized by mucous and fibroblastic tissues.
Paul
2012-03-20T11:45:41Z
Fibromyxoma
mouse_pathology.ontology
fibroma myxomatodes.
MPATH:823
myxofibroma
A benign neoplasm characterized by mucous and fibroblastic tissues.
MPATH:curation
A benign localized neoplasm arising from the subcutaneous tissues and skeletal muscle. It is characterized by the presence of myofibroblastic hyperchromatic spindle cells, hylanized stroma formation, calcification, necrosis, and a multinodular growth pattern.
Paul
2012-03-20T11:51:59Z
mouse_pathology.ontology
Solitary Myofibromatosis
MPATH:824
myofibroma
A benign localized neoplasm arising from the subcutaneous tissues and skeletal muscle. It is characterized by the presence of myofibroblastic hyperchromatic spindle cells, hylanized stroma formation, calcification, necrosis, and a multinodular growth pattern.
CUI:C1266121
Generation of intracytoplasmic vacuoles otherwise unspecified.
Paul
2012-03-22T08:19:10Z
mouse_pathology.ontology
MPATH:825
vacuolation
Generation of intracytoplasmic vacuoles otherwise unspecified.
MPATH:curation
granulomatous inflammation of the skin
Paul
2012-03-22T08:22:17Z
mouse_pathology.ontology
MPATH:826
granulomatous dermatitis
granulomatous inflammation of the skin
MPATH:curation
chronic inflammation of the skin
Paul
2012-03-22T08:24:43Z
mouse_pathology.ontology
MPATH:827
chronic dermatitis
chronic inflammation of the skin
MPATH:curation
locally demarcated region of inflammation in the skin
Paul
2012-03-22T08:33:42Z
mouse_pathology.ontology
MPATH:828
focal dermatitis
locally demarcated region of inflammation in the skin
MPATH:curation
possession of both ovary and testis due to primary sex determination defect
Paul
2012-03-22T08:42:35Z
mouse_pathology.ontology
MPATH:829
true hermaphrodite
possession of both ovary and testis due to primary sex determination defect
MPATH:curation
Any defect in the formation of septae not describable as perforation.
mouse_pathology.ontology
MPATH:83
septation defect
Any defect in the formation of septae not describable as perforation.
Pathbase: Curation
repair, reproduction, or replacement of lost or injured cells, tissues, or organs.
Paul
2012-03-22T08:45:44Z
mouse_pathology.ontology
MPATH:830
regeneration
repair, reproduction, or replacement of lost or injured cells, tissues, or organs.
MPATH:curation
multilocular sites of muscle regeneration with centrally located nuclei.
Paul
2012-03-22T08:48:14Z
mouse_pathology.ontology
MPATH:831
multifocal muscle regeneration
multilocular sites of muscle regeneration with centrally located nuclei.
MPATH:curation
persistent retraction of the prepuce behind the glans penis
Paul
2012-03-22T08:52:08Z
mouse_pathology.ontology
MPATH:832
generally due to inflammation, but can cause further inflammation which exacerbates the condition
paraphimosis
persistent retraction of the prepuce behind the glans penis
MPATH:curation
transition between acute and chronic inflammation.
Paul
2012-03-22T08:55:14Z
mouse_pathology.ontology
MPATH:833
time varies form a few days to a week or so. Cells mainly lymphocytes and plasma cells, few macrophages or neutrophils. Less hemorrhage, edema and hyperemia.
subacute inflammation
transition between acute and chronic inflammation.
mpath:curation
non-malignant neoplasia of the ovary.
Paul
2012-03-22T09:04:54Z
mouse_pathology.ontology
tubular adenoma
MPATH:834
ovarian tubulostromal tumor
non-malignant neoplasia of the ovary.
ISBN:0-944398-45-6
MPATH:curation
acute inflammation due to infection.
Paul
2012-03-22T03:38:07Z
mouse_pathology.ontology
MPATH:835
acute septic inflammation
acute inflammation due to infection.
MPATH:curation
fibrosis in the skin
Paul
2012-03-22T05:06:25Z
mouse_pathology.ontology
MPATH:836
dermal fibrosis
fibrosis in the skin
MPATH:curation
Fatty change in the mid-zonal region of the liver.
Paul
2012-03-22T05:23:46Z
mouse_pathology.ontology
MPATH:837
hepatic mid-zonal fatty metamorphosis
Fatty change in the mid-zonal region of the liver.
MPATH:curation
carcinoma with an absence of epithelial structural differentiation.
Paul
2012-03-22T05:26:31Z
mouse_pathology.ontology
MPATH:838
anaplastic carcinoma
carcinoma with an absence of epithelial structural differentiation.
MPATH:curation
anaplastic carcinoma of the liver.
Paul
2012-03-22T05:28:22Z
mouse_pathology.ontology
MPATH:839
anaplastic hepatocellular carcinoma
anaplastic carcinoma of the liver.
MPATH:curation
Additional structure whether normally located or not.
mouse_pathology.ontology
MPATH:84
supernumerary structure
Additional structure whether normally located or not.
Pathbase: Curation
arthitis involving extensive macrophage infiltration into the joint.
Paul
2012-03-22T05:37:23Z
mouse_pathology.ontology
MPATH:840
granulomatous arthritis
arthitis involving extensive macrophage infiltration into the joint.
MPATH:curation
Absence of eye.
Paul
2012-03-22T05:40:44Z
mouse_pathology.ontology
MPATH:841
may be uni or bilateral
anopthalmia
Absence of eye.
MPATH:curation
abnormally shaped vertebral body often triangular as opposed to rectangular.
Paul
2012-03-22T05:55:21Z
mouse_pathology.ontology
MPATH:842
spontaneous or induced developmental lesion
coccygeal hemivertebrae
abnormally shaped vertebral body often triangular as opposed to rectangular.
PMID:1666161
Cessation of movement of a body fluid or liquid.
Paul
2012-03-22T06:05:28Z
mouse_pathology.ontology
MPATH:843
stasis
Cessation of movement of a body fluid or liquid.
MPATH:curation
Cessation of the flow of bile due to bile duct blockage or overproduction.
Paul
2012-03-22T06:06:41Z
mouse_pathology.ontology
MPATH:844
biliary stasis
Cessation of the flow of bile due to bile duct blockage or overproduction.
MPATH:curation
Evidence of residual placenta in utero without embryo.
Paul
2012-03-24T03:03:26Z
mouse_pathology.ontology
MPATH:845
partial abortion
Evidence of residual placenta in utero without embryo.
MPATH:curation
acute inflammation of the footpad caused by foreign body.
Paul
2012-03-24T03:05:46Z
mouse_pathology.ontology
MPATH:846
foreign body acute pododermatitis
acute inflammation of the footpad caused by foreign body.
MPATH:curation
Collection of epithelioid macrophages into a nodule
Paul
2012-03-24T03:19:38Z
mouse_pathology.ontology
MPATH:847
granuloma
Collection of epithelioid macrophages into a nodule
MPATH:curation
Replacement of normal tissue by granuloma.
Paul
2012-03-24T03:22:52Z
mouse_pathology.ontology
MPATH:848
effacing granuloma
Replacement of normal tissue by granuloma.
MPATH:curation
poorly differentiated adenocarcinoma of the mammary gland
Paul
2012-03-24T03:26:01Z
mouse_pathology.ontology
MPATH:849
anaplastic mammary adenocarcinoma
poorly differentiated adenocarcinoma of the mammary gland
MPATH:curation
Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state.
mouse_pathology.ontology
MPATH:85
This term is generally used in the context of embryonic cells or stem cells.
transdifferentiation
Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state.
Pathbase: Pathology Committee
Morphological abnormality following trauma or related insult such as infection.
Paul
2012-03-24T03:28:03Z
mouse_pathology.ontology
MPATH:850
post-traumatic structural abnormality
Morphological abnormality following trauma or related insult such as infection.
MPATH:curation
acquired dysmorphology of the external pinna following trauma or infection.
Paul
2012-03-24T03:29:48Z
mouse_pathology.ontology
MPATH:851
auricular deformation
acquired dysmorphology of the external pinna following trauma or infection.
MPATH:curation
A condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood.
Paul
2012-03-24T03:32:23Z
mouse_pathology.ontology
MPATH:852
plasmacytosis
A condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood.
MPAHTH:curation
Abnormality of circulating plasma cells
Paul
2012-03-24T03:33:57Z
mouse_pathology.ontology
MPATH:853
systemic plasmacytosis
Abnormality of circulating plasma cells
MPATH:curation
Plasmacytosis in the skin.
Paul
2012-03-24T03:35:42Z
mouse_pathology.ontology
MPATH:854
cutaneous plasmacytosis
Plasmacytosis in the skin.
MPATH:curation
In vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances.
Paul
2012-03-24T03:38:37Z
mouse_pathology.ontology
MPATH:855
Splendore-Hoeppli phenomenon
In vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances.
PMID:18976399
Rupture of alveolar walls result in large rounded open air spaces in the lung
Paul
2012-03-24T03:43:52Z
mouse_pathology.ontology
MPATH:856
bullous emphysema
Rupture of alveolar walls result in large rounded open air spaces in the lung
MPATH:curation
mutilocular bullous emphysema
Paul
2012-03-24T03:45:01Z
mouse_pathology.ontology
MPATH:857
multifocal bullous emphysema
mutilocular bullous emphysema
MPATH:curation
Benign proliferation of capillaries made up of closely packed aggregations of capillaries, usually of normal caliber, separated by scant connective stroma.
Paul
2012-03-24T03:46:38Z
mouse_pathology.ontology
MPATH:858
Most common kind of hemangioma thought to be derived from primitive mesenchymal stem cells.
capillary hemangioma
Benign proliferation of capillaries made up of closely packed aggregations of capillaries, usually of normal caliber, separated by scant connective stroma.
MPATH:curation
Chronic granulomatous bacterial infection that affects the skin, and sometimes the viscera. Usually caused by S. aureus.
Paul
2012-03-24T03:52:35Z
mouse_pathology.ontology
MPATH:859
botryomycosis
Chronic granulomatous bacterial infection that affects the skin, and sometimes the viscera. Usually caused by S. aureus.
ISBN: 0-7216-2921-0.
Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations.
mouse_pathology.ontology
MPATH:86
organ specific developmental defect
Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations.
Pathbase: Curation
inflammation of the gall bladder
Paul
2012-03-24T04:11:00Z
mouse_pathology.ontology
MPATH:860
cholecystitis
inflammation of the gall bladder
MPATH:curation
cholecystitis associated with edema
Paul
2012-03-24T04:11:43Z
mouse_pathology.ontology
MPATH:861
edematous cholecystitis
cholecystitis associated with edema
MPATH:curation
Accumulation or trapping of air
Paul
2012-03-24T04:17:10Z
mouse_pathology.ontology
MPATH:862
flatus
Accumulation or trapping of air
MPATH:curation
circumscribed ulceration of the skin penetrating the basement membrane as part of inflammation process.
Paul
2012-03-24T04:18:54Z
mouse_pathology.ontology
MPATH:863
focal ulcerative dermatitis
circumscribed ulceration of the skin penetrating the basement membrane as part of inflammation process.
MPATH:curation
Inflammation of the outer ear.
Paul
2012-03-25T10:00:59Z
mouse_pathology.ontology
MPATH:864
otitis externa
Inflammation of the outer ear.
MPATH:curation
Papillomatous inflammation of the tongue caused by a foreign body.
Paul
2012-03-25T10:49:17Z
mouse_pathology.ontology
MPATH:865
foreign body acute papillomatous glossitis
Papillomatous inflammation of the tongue caused by a foreign body.
MPATH:curationf>
Thickening of the glandular epithelium
Paul
2012-03-25T10:59:20Z
mouse_pathology.ontology
MPATH:866
Often with crystalloid formation
gastric adenomatous hyperplasia
Thickening of the glandular epithelium
MPATH:curation
Major hepatic vein surrounded by fibrous connective tissue.
Paul
2012-03-25T11:02:20Z
mouse_pathology.ontology
MPATH:867
hepatic central vein perivascular fibrosis
Major hepatic vein surrounded by fibrous connective tissue.
MPATH:curation
Dilation of the uterus
Paul
2012-03-25T11:58:56Z
mouse_pathology.ontology
hydrometra
MPATH:868
Usually assciated iwth hydrpometra
uterine ectasia
Dilation of the uterus
MPATH:curation
Condition in which a part of the intestine has invaginated into another section of intestine,
Paul
2012-03-25T12:04:33Z
mouse_pathology.ontology
MPATH:869
intussception
Condition in which a part of the intestine has invaginated into another section of intestine,
MPATH:curation
Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic.
mouse_pathology.ontology
MPATH:87
germ cell defect
Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic.
Pathbase: Curation
severe type of the disorder generally apparent at birth.Junctional epidermolysis bullosa involves defects in hemidesmosomes. t
Paul
2012-03-25T12:10:57Z
mouse_pathology.ontology
MPATH:870
junctional epidermolysis bullosa
severe type of the disorder generally apparent at birth.Junctional epidermolysis bullosa involves defects in hemidesmosomes. t
MPATH:curation
Structural defects of the bony and muscular components of the vertebrae.
Paul
2012-03-25T12:15:53Z
mouse_pathology.ontology
MPATH:871
spinal structural defects
Structural defects of the bony and muscular components of the vertebrae.
MPATH:curation
Abnormality of the kyphotic curvature of the spine.
Paul
2012-03-25T12:17:10Z
mouse_pathology.ontology
MPATH:872
kyphosis
Abnormality of the kyphotic curvature of the spine.
MPATH:curation
Reduced size of the eye globe.
Paul
2012-03-25T12:21:30Z
mouse_pathology.ontology
MPATH:873
micropthalmia
Reduced size of the eye globe.
MPATH:curation
Plasmacytosis is a hyperplastic condition in which there is an unusually large proportion of mature plasma cells in tissues, exudates, or blood.
Paul
2012-09-03T04:32:06Z
mouse_pathology.ontology
MPATH:874
plasmacytosis
Plasmacytosis is a hyperplastic condition in which there is an unusually large proportion of mature plasma cells in tissues, exudates, or blood.
MPATH:Pathology Committee
cutaneous manifestation of plasmacytosis
Paul
2012-09-03T04:36:31Z
mouse_pathology.ontology
MPATH:875
cutaneous plasmacytosis
cutaneous manifestation of plasmacytosis
MPATH:Pathology Committee
systemic manifestation of plasmacytosis. Disseminated in the circulation.
Paul
2012-09-03T04:37:32Z
mouse_pathology.ontology
MPATH:876
systemic plasmacytosis
systemic manifestation of plasmacytosis. Disseminated in the circulation.
MPATH:Pathology Committee
An inflammatory condition of the lung, especially affecting the alveoli, associated with fever, chest symptoms, and congestion.
Paul
2012-09-03T05:30:23Z
mouse_pathology.ontology
MPATH:877
Typically caused by an infection but there are a number of other causes. Infectious agents include: bacteria, viruses, fungi, and parasites.
pneumonia
An inflammatory condition of the lung, especially affecting the alveoli, associated with fever, chest symptoms, and congestion.
http://en.wikipedia.org/wiki/Pneumonia
Pneumonia caused by aspiration of a foreign body.
Paul
2012-09-03T05:34:45Z
mouse_pathology.ontology
MPATH:878
foreign body aspiration pneumonia
Pneumonia caused by aspiration of a foreign body.
MPATH:Pathology Committee
Inflammation of the tooth gum
Paul
2012-09-03T05:37:29Z
mouse_pathology.ontology
MPATH:879
gingivitis
Inflammation of the tooth gum
MPATH:Pathology Committee
nephroblastomatosis
mouse_pathology.ontology
MPATH:88
Obsolete - subsumed into MPATH:82
nephroblastomatosis
true
nephroblastomatosis
Pathbase: Curation
inflammation of the tooth gum caused by a foreign body.
Paul
2012-09-03T05:38:14Z
mouse_pathology.ontology
MPATH:880
Generally caused by hair or food debris
foreign body gingivitis
inflammation of the tooth gum caused by a foreign body.
MAPTH:<new dbxref>
MPATH:Pathology Committee
Fibrotic reaction to presence of a foreign body.
Paul
2012-09-03T05:44:35Z
mouse_pathology.ontology
MPATH:881
reactive fibrosis
Fibrotic reaction to presence of a foreign body.
MPATH:Pathology Committee
Inflammatory cell infiltrate around bile ducts within the liver.
Paul
2012-09-04T11:07:32Z
mouse_pathology.ontology
MPATH:882
hepatic peri-ductal inflammation
Inflammatory cell infiltrate around bile ducts within the liver.
MPATH:JPS
An interstitial, granulomatous, fibrosing inflammation of the lung, especially of the bronchioles and alveoli.
Paul
2012-09-04T11:18:21Z
mouse_pathology.ontology
MPATH:883
pneumonitis
An interstitial, granulomatous, fibrosing inflammation of the lung, especially of the bronchioles and alveoli.
MPATH:JPS
Pneumonitis involving subpleural histiocytosis.
Paul
2012-09-04T11:19:22Z
mouse_pathology.ontology
MPATH:884
histiocytic pneumonitis
Pneumonitis involving subpleural histiocytosis.
MPATH:JPS
metastatic tumour of unspecified origin
Paul
2012-09-04T11:28:57Z
mouse_pathology.ontology
MPATH:885
metastatic tumor
metastatic tumour of unspecified origin
MPATH:Pathology Committee
Metastatic tumour of unspecified origin in the lung.
Paul
2012-09-04T11:30:02Z
mouse_pathology.ontology
MPATH:886
pulmonary metastasis
Metastatic tumour of unspecified origin in the lung.
MPATH:Pathology Committee
Metastatic tumor in the lymphatic vessels or lymph nodes of unspecified origin.
Paul
2012-09-04T11:32:15Z
mouse_pathology.ontology
MPATH:887
lymphatic metastasis
Metastatic tumor in the lymphatic vessels or lymph nodes of unspecified origin.
MPATH:Pathology Committee
Hypertrophy of the nail bed resulting in abnormally long, curved and thickened nails.
Paul
2012-09-04T12:10:49Z
mouse_pathology.ontology
MPATH:888
onychogryphosis
Hypertrophy of the nail bed resulting in abnormally long, curved and thickened nails.
MPATH:JPS
intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano. PMID: 21978358
Paul
2020-05-19T02:38:14Z
mouse_pathology.ontology
MPATH:889
Hirano body
intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano. PMID: 21978358
MPATH:PNS
Abnormal development of the heart or vascular tissue resulting in morphological abnormality.
mouse_pathology.ontology
MPATH:89
cardiovascular developmental defect
Abnormal development of the heart or vascular tissue resulting in morphological abnormality.
Pathbase: Curation
Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin.
mouse_pathology.ontology
MPATH:9
Frequently occurs in the walls of blood vessels and in connective tissue in diseases such as disseminated Lupus erythrematosis and polyarteritis nodosa, scleroderma, dermatomyositis and rheumatic fever.
fibrinoid necrosis
Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin.
ISBN:0781727286
Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber.
mouse_pathology.ontology
MPATH:90
aneurysm
Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber.
Pathbase: Pathology Committee
Formation of vessels between arterioles and venules bypassing capillary circulation.
mouse_pathology.ontology
Anastomosis arteriolovenularis
anastomosis arteriovenosa
arteriolovenular anastomosis
MPATH:91
arteriovenous anastomosis
Formation of vessels between arterioles and venules bypassing capillary circulation.
Pathbase: Curation
Anastomosis arteriolovenularis
Pathbase: Curation
anastomosis arteriovenosa
Pathbase: Curation
arteriolovenular anastomosis
Pathbase: Curation
Structural, organisational or growth related defects in cardiac development.
mouse_pathology.ontology
heart abnormalities
MPATH:92
cardiac defect
Structural, organisational or growth related defects in cardiac development.
Pathbase: Curation
heart abnormalities
Pathbase: Curation
Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure.
mouse_pathology.ontology
MPATH:93
cardiac septation defect
Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure.
Pathbase: Curation
Malformation of the membranous folds of the heart that prevent reflux of fluid.
mouse_pathology.ontology
MPATH:94
valve defect
Malformation of the membranous folds of the heart that prevent reflux of fluid.
Pathbase: Curation
Thickening of the wall of one or both of the heart ventricles.
mouse_pathology.ontology
MPATH:95
hypertrophic ventricle
Thickening of the wall of one or both of the heart ventricles.
Pathbase: Pathology Committee
Reduction in cell number of one or both of the two lower chambers of the heart.
mouse_pathology.ontology
MPATH:96
hypoplastic ventricle
Reduction in cell number of one or both of the two lower chambers of the heart.
Pathbase: Pathology Committee
Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima.
mouse_pathology.ontology
MPATH:97
dissecting aneurysm
Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima.
ISBN:0781727286
A stretching and widening of the lymphatic vessels.
mouse_pathology.ontology
Lymphectasia
telangiectasia lymphatica
MPATH:98
lymphangiectasis
A stretching and widening of the lymphatic vessels.
Pathbase: Pathology Committee
Lymphectasia
Pathbase: Curation
telangiectasia lymphatica
Pathbase: Curation
An enlarged and often tortuous vein.
mouse_pathology.ontology
MPATH:99
varices
An enlarged and often tortuous vein.
Pathbase: Pathology Committee