Harrison Strachan He Zhang Jingshan Huang Asiyah Yu Lin December 2015: This ontology is currently undergoing changes. ID deprecation policies will start in the next couple of months. In the mean time, identifiers may be deleted and not marked obsolete. Alan Ruttenberg definition antisymmetric property is_gene_template_of_mRNA is_model_of_disease He_Zhang 2015-05-17T07:52:46Z is_predicted_target_of miRNA_expressed_in_tissue regulate_miRNA_transcription regulate_mRNA_translation 2015-05-17T07:51:13Z has_predicted_target tRNA rRNA RNA snRNA circRNA miRNA_target_gene_primary_transcript miRNA_target_gene_mRNA miRNA_and_target_gene_binding fly_miRNA c_elegans_miRNA bacterial_miRNA virus_miRNA miRBase:MI0003592 non_mammalian_miRNA mammalian_miRNA miRNA_expression transcription_of_miRNA 2015-05-25T15:37:18Z miRNA_target_gene He_Zhang 2015-05-16T19:26:04Z human_miRNA A non-coding RNA (ncRNA) is an RNA molecule that is not translated into a protein. Alan Ruttenberg ncRNA WEB:https://en.wikipedia.org/w/index.php?title=Non-coding_RNA&oldid=688555892#Non-coding RNA non-coding RNA A short (20-24 nt) miRNA gene product that is derived from pre-miRNA that is exported from the nucleus and is capable of being involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs after being incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA. Alan Ruttenberg RefSeq, Sep 2009 mature miRNA A genetic non-coding RNA is a non-coding RNA that is created by transcription in a cell Alan Ruttenberg TODO: Add axiom linking GO transcription genetic non-coding RNA Alan Ruttenberg a RNA that is manufactured in a planned process TODO: Add axiom relating to OBI planned process and anything else from OBI that is relevant synthesized non-coding RNA Long non-coding RNAs (long ncRNAs, lncRNA) are non-protein coding transcripts longer than 200 nucleotides. This somewhat arbitrary limit distinguishes long ncRNAs from small regulatory RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs Alan Ruttenberg lncRNA WEB:https://en.wikipedia.org/w/index.php?title=Long_non-coding_RNA&oldid=687562040#Long non-coding RNA Should requested and then imported from ChEBI long non-coding RNA small interfering RNA (siRNA) is a class of double-stranded RNA molecules, 20-25 base pairs in length. siRNA plays many roles, but it is most notable in the RNA interference (RNAi) pathway, where it interferes with thes expression of specific genes with complementary nucleotide sequences. Alan Ruttenberg siRNA WEB:https://en.wikipedia.org/w/index.php?title=Special:CiteThisPage&page=Small_interfering_RNA&id=685334024#Small_interfering_RNA Should requested and then imported from ChEBI small interfering RNA miRNA target disposition A miRNA gene product which is capped, inside the nucleus, with a specially modified nucleotide at the 5’ end, polyadenylated with multiple adenosines (a poly(A) tail),[49][53] and spliced, forming an RNA stem-loop that in turn is part of this miRNA precursor Alan Ruttenberg Refseq, Wikipedia primary miRNA A non-coding RNA product initially transcribed from a DNA gene, or derived from such RNA by post-transcriptional processing to become capable of forming part of a RNA silencing complex and participating in gene silencing. Alan Ruttenberg 2016-02-01: Stance on identity: pri-miNRA, pre-miRNA, and mature miRNA are disjoint. It is a process of derivation that results first from pri-miRNA to pre-miRNA then to miRNA. The identity of an miRNA gene product is determined by the molecule from which it is transcribed or derived and by its own nucleotide sequence. We have to be careful in the definitions to not undermine this position. Alan Ruttenberg miRNA gene product A miRNA gene product cleaved from a pri-miRNA by Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor to mature miRNA, which is cleaved from the pre-miRNA by cytoplasmic Dicer ribonuclease . Alan Ruttenberg Refseq, Wikipedia pre-miRNA An miRNA gene product from which a mature miRNA is capable of being derived. Alan Ruttenberg miRNA precursor Removed axiom 'derives_from some miRNA_primary_transcript' pending review of status of SO terms. Changed relation of small regulatory ncRNA (superclass) into is about relationship